Homo sapiens

175 known processes

KDM1A

lysine (K)-specific demethylase 1A

(Aliases: AOF2,LSD1,BHC110,KIAA0601,KDM1)

KDM1A biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
chromatin modificationGO:00165682981.000
chromatin organizationGO:00063253511.000
negative regulation of transcription from rna polymerase ii promoterGO:00001222811.000
histone modificationGO:00165702511.000
covalent chromatin modificationGO:00165692541.000
histone methylationGO:0016571600.996
Mouse
atp dependent chromatin remodelingGO:0043044250.996
methylation dependent chromatin silencingGO:000634630.973
macromolecule methylationGO:0043414970.966
Mouse
protein deacylationGO:0035601390.900
chromatin silencing at rdnaGO:000018350.890
protein methylationGO:0006479740.882
Mouse
digestive tract developmentGO:0048565750.865
methylationGO:00322591060.862
Mouse
chromatin remodelingGO:0006338550.842
chromatin assembly or disassemblyGO:0006333780.836
macromolecule deacylationGO:0098732410.789
peptidyl lysine modificationGO:00182051440.767
digestive system developmentGO:0055123750.715
histone deacetylationGO:0016575320.709
regulation of cell cycleGO:00517263930.673
ribonucleoside monophosphate metabolic processGO:00091611870.661
regulation of circadian rhythmGO:0042752110.627
protein alkylationGO:0008213740.594
Mouse
proteolysis involved in cellular protein catabolic processGO:00516032440.564
response to abiotic stimulusGO:00096283360.475
regulation of gene expression epigeneticGO:0040029730.468
nucleoside monophosphate metabolic processGO:00091231910.457
protein catabolic processGO:00301633250.442
histone arginine methylationGO:003496960.428
wnt signaling pathwayGO:00160551560.427
histone lysine methylationGO:0034968500.424
Mouse
tissue regenerationGO:004224630.421
cellular macromolecule catabolic processGO:00442653800.398
cellular protein catabolic processGO:00442572610.381
positive regulation of chromosome organizationGO:2001252410.342
regenerationGO:003109940.332
double strand break repairGO:00063021010.313
regulation of megakaryocyte differentiationGO:0045652220.313
Mouse
negative regulation of circadian rhythmGO:004275410.307
protein deacetylationGO:0006476380.306
purine ribonucleoside monophosphate metabolic processGO:00091671860.298
cellular response to decreased oxygen levelsGO:0036294510.267
hair follicle developmentGO:0001942110.235
protein ubiquitinationGO:00165673140.232
negative regulation of intracellular signal transductionGO:19025321830.222
positive regulation of protein autoubiquitinationGO:190249920.219
peptidyl lysine acetylationGO:00183941010.216
positive regulation of protein ubiquitinationGO:0031398530.214
mesenchymal cell developmentGO:0014031500.212
negative regulation of canonical wnt signaling pathwayGO:0090090550.208
positive regulation of cellular component organizationGO:00511303760.207
Rat
cellular response to hypoxiaGO:0071456510.204
ameboidal type cell migrationGO:00016671350.192
defense responseGO:00069523150.191
regulation of establishment of protein localizationGO:00702012420.191
cellular response to dna damage stimulusGO:00069743790.190
cytokinesisGO:0000910960.185
cellular macromolecular complex assemblyGO:00346223240.177
post embryonic developmentGO:000979120.170
taxisGO:00423301570.160
secretionGO:00469032540.160
regulation of protein ubiquitinationGO:0031396950.160
modification dependent macromolecule catabolic processGO:00436322120.156
ubiquitin dependent protein catabolic processGO:00065112060.151
rhythmic processGO:0048511310.150
protein autoubiquitinationGO:0051865370.149
mesenchyme developmentGO:0060485590.145
regulation of protein transportGO:00512232130.137
digestive tract morphogenesisGO:0048546560.135
negative regulation of axonogenesisGO:005077140.133
positive regulation of cell morphogenesis involved in differentiationGO:0010770500.130
wound healingGO:00420601150.128
purine nucleoside monophosphate metabolic processGO:00091261860.127
endomembrane system organizationGO:00102561960.123
central nervous system developmentGO:00074171230.122
Mouse Rat
cell fate determinationGO:000170930.122
regulation of triglyceride metabolic processGO:0090207110.122
chromatin silencingGO:0006342120.117
purine ribonucleoside triphosphate metabolic processGO:00092054110.116
regulation of protein autoubiquitinationGO:190249830.116
canonical wnt signaling pathwayGO:00600701160.111
regulation of keratinocyte proliferationGO:0010837110.110
negative regulation of protein modification processGO:00314002000.105
Mouse
positive regulation of protein modification by small protein conjugation or removalGO:1903322610.105
modification dependent protein catabolic processGO:00199412090.104
purine ribonucleoside monophosphate catabolic processGO:00091691580.104
proteasomal protein catabolic processGO:00104981760.102
atp catabolic processGO:00062001570.101
cellular response to oxidative stressGO:0034599850.097
histone acetylationGO:0016573930.097
regulation of protein localizationGO:00328802960.096
embryonic morphogenesisGO:0048598850.096
negative regulation of multicellular organismal processGO:00512413170.095
epithelial cell migrationGO:00106311190.093
histone h4 r3 methylationGO:004398530.091
circadian rhythmGO:0007623210.091
posttranscriptional regulation of gene expressionGO:00106082130.090
megakaryocyte differentiationGO:0030219250.087
Mouse
internal peptidyl lysine acetylationGO:0018393970.086
response to decreased oxygen levelsGO:0036293960.082
regulation of protein modification by small protein conjugation or removalGO:19033201070.082
positive regulation of organelle organizationGO:00106381950.081
microtubule based processGO:00070172100.080
muscle organ developmentGO:0007517560.079
dna repairGO:00062811980.078
spindle organizationGO:0007051530.077
lipid catabolic processGO:0016042840.077
chemotaxisGO:00069351570.073
peptidyl lysine methylationGO:0018022370.071
response to external biotic stimulusGO:00432072610.071
cell divisionGO:00513011680.070
regulation of canonical wnt signaling pathwayGO:0060828880.070
histone h4 deacetylationGO:007093380.070
response to nitrogen compoundGO:19016981840.068
Rat
protein acylationGO:00435431380.068
negative regulation of gene expression epigeneticGO:0045814190.066
cellular lipid catabolic processGO:0044242650.063
protein localization to organelleGO:00333652800.063
purine nucleoside monophosphate catabolic processGO:00091281580.062
determination of adult lifespanGO:000834020.061
hair follicle morphogenesisGO:003106920.060
regulation of inflammatory responseGO:0050727460.060
oogenesisGO:004847720.060
circadian regulation of gene expressionGO:003292280.060
regulation of cell motilityGO:20001452990.060
regulation of secretion by cellGO:19035301770.060
cellular response to nitrogen compoundGO:19016991440.059
Rat
tube developmentGO:00352951250.059
hair cycleGO:0042633280.058
protein dephosphorylationGO:0006470810.056
rna interferenceGO:001624640.056
regulation of response to external stimulusGO:00321012220.056
generation of neuronsGO:00486991520.056
Rat
reproductive structure developmentGO:0048608550.055
negative regulation of organelle organizationGO:00106391260.054
Mouse
protein modification by small protein conjugationGO:00324463420.053
response to oxygen containing compoundGO:19017003690.052
Rat
regulation of myeloid cell differentiationGO:0045637810.052
Mouse
vesicle mediated transportGO:00161923710.052
negative regulation of wnt signaling pathwayGO:0030178690.051
regulation of cell growthGO:00015581350.051
small molecule catabolic processGO:0044282920.051
regulation of defense responseGO:00313471540.050
nuclear divisionGO:00002801280.050
protein secretionGO:0009306980.049
vitamin d receptor signaling pathwayGO:007056140.049
protein acetylationGO:00064731160.049
growthGO:00400072020.048
microtubule cytoskeleton organizationGO:00002261760.048
circadian behaviorGO:004851220.048
purine ribonucleoside metabolic processGO:00461284370.048
centrosome organizationGO:0051297580.048
regulation of cell cycle processGO:00105642660.047
regulation of epithelial to mesenchymal transitionGO:0010717370.047
negative regulation of apoptotic processGO:00430663160.047
regulation of dna metabolic processGO:00510521530.046
negative regulation of protein transportGO:0051224750.045
regulation of protein bindingGO:0043393660.044
notch signaling involved in heart developmentGO:006131420.044
regulation of intracellular steroid hormone receptor signaling pathwayGO:0033143320.043
negative regulation of catalytic activityGO:00430863350.043
regulation of proteolysisGO:00301622930.043
regulation of cell developmentGO:00602841610.041
Rat
photoreceptor cell differentiationGO:004653020.041
secretion by cellGO:00329402260.039
reproductive processGO:00224141060.039
dna conformation changeGO:00711031130.038
positive regulation of cell proliferationGO:00082843010.038
Mouse
fatty acid catabolic processGO:0009062290.038
regulation of chromatin modificationGO:1903308510.038
Mouse
regulation of mitosisGO:0007088630.037
cell fate specificationGO:000170880.037
tissue migrationGO:00901301190.036
cell growthGO:00160491600.036
epithelial cell proliferationGO:00506731280.036
mitotic cytokinesisGO:0000281190.036
protein maturationGO:00516042330.036
positive regulation of apoptotic processGO:00430652460.035
response to organic cyclic compoundGO:00140702040.035
Rat
dephosphorylationGO:00163112090.035
protein targeting to nucleusGO:00447441040.035
cellular response to oxygen levelsGO:0071453550.034
single organism reproductive processGO:0044702980.034
nucleosome positioningGO:001658430.034
embryonic organ developmentGO:0048568360.033
Mouse
small gtpase mediated signal transductionGO:0007264780.032
protein deubiquitinationGO:0016579790.032
regulation of locomotionGO:00400123290.032
nucleoside monophosphate catabolic processGO:00091251590.032
alcohol metabolic processGO:00060661140.031
negative regulation of intrinsic apoptotic signaling pathwayGO:2001243400.031
nervous system developmentGO:00073992930.031
Mouse Rat
regulation of epithelial cell proliferationGO:00506781130.030
negative regulation of protein metabolic processGO:00512483910.030
Mouse
negative regulation of developmental processGO:00510932470.030
peptidyl arginine methylation to asymmetrical dimethyl arginineGO:001991920.030
establishment of protein localization to plasma membraneGO:0090002680.030
multicellular organism reproductionGO:0032504420.029
rhythmic behaviorGO:000762220.029
locomotory behaviorGO:000762610.029
hair cycle processGO:0022405120.029
epidermis morphogenesisGO:004873030.029
negative regulation of cell developmentGO:0010721480.029
response to radiationGO:00093141510.029
monocarboxylic acid catabolic processGO:0072329370.029
positive regulation of programmed cell deathGO:00430682490.028
axis elongationGO:000340140.028
reactive oxygen species biosynthetic processGO:190340940.028
multicellular organismal reproductive processGO:0048609400.028
cellular response to lipidGO:00713961270.028
epithelial to mesenchymal transitionGO:0001837480.028
regulation of cellular component movementGO:00512703340.027
peptidyl arginine n methylationGO:003524660.027
ribonucleoside monophosphate catabolic processGO:00091581580.027
organic acid catabolic processGO:0016054710.027
regulation of mitotic cell cycleGO:00073461890.026
cell projection morphogenesisGO:00488581290.026
ribonucleoside triphosphate metabolic processGO:00091994120.026
cellular response to insulin stimulusGO:0032869410.026
positive regulation of dna metabolic processGO:0051054730.026
mesenchymal cell differentiationGO:0048762520.026
rna processingGO:00063962550.025
Rat
regulation of protein localization to nucleusGO:1900180850.025
keratinocyte proliferationGO:0043616170.025
endothelial cell proliferationGO:0001935650.025
protein importGO:00170381300.025
sprouting angiogenesisGO:0002040290.025
dna dependent dna replicationGO:0006261440.024
molting cycleGO:0042303280.024
protein localization to nucleusGO:00345041360.024
negative regulation of steroid biosynthetic processGO:0010894150.024
neural crest cell developmentGO:001403230.024
immune system developmentGO:00025201950.024
Mouse
fatty acid metabolic processGO:00066311150.024
microtubule organizing center organizationGO:0031023620.024
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280690.024
negative regulation of cellular amino acid metabolic processGO:004576320.024
oocyte differentiationGO:000999420.023
purine nucleoside catabolic processGO:00061523980.023
apoptotic signaling pathwayGO:00971902680.023
regulation of receptor biosynthetic processGO:0010869150.023
carboxylic acid catabolic processGO:0046395710.023
response to oxidative stressGO:00069791210.023
heat acclimationGO:001028630.022
pancreas developmentGO:0031016190.022
negative regulation of epithelial cell proliferationGO:0050680480.022
negative regulation of vitamin d biosynthetic processGO:001095750.022
chordate embryonic developmentGO:0043009340.021
Mouse
regulation of cell differentiationGO:00455953930.021
Mouse Rat
hormone secretionGO:0046879650.021
positive regulation of chromatin modificationGO:1903310300.021
positive regulation of cell differentiationGO:00455972110.021
Mouse Rat
positive regulation of cell deathGO:00109422630.020
cell migration involved in gastrulationGO:004207410.020
organic hydroxy compound metabolic processGO:19016151470.020
positive regulation of histone modificationGO:0031058290.020
regulation of response to woundingGO:19030341010.020
asymmetric stem cell divisionGO:009872210.020
regulation of protein secretionGO:0050708860.020
response to lipidGO:00339932060.020
response to other organismGO:00517072610.020
nucleosome organizationGO:0034728660.020
response to woundingGO:00096111680.020
establishment or maintenance of cell polarityGO:0007163310.020
developmental process involved in reproductionGO:0003006660.020
muscle structure developmentGO:0061061980.019
Mouse
positive regulation of hematopoietic progenitor cell differentiationGO:190153450.019
Mouse
regulation of synaptic plasticityGO:004816730.019
response to hypoxiaGO:0001666960.019
negative regulation of lipid metabolic processGO:0045833380.019
regulation of endopeptidase activityGO:00525481700.019
reproductive system developmentGO:0061458560.019
regulation of growthGO:00400081650.019
negative regulation of cell cell adhesion by negative regulation of transcription from rna polymerase ii promoterGO:190038710.019
negative regulation of transportGO:00510511760.019
protein processingGO:00164852260.019
organelle fissionGO:00482851490.019
mrna metabolic processGO:00160711750.019
Rat
response to metal ionGO:0010038840.019
negative regulation of kinase activityGO:00336731060.019
negative regulation of cell growthGO:0030308830.019
chromatin assemblyGO:0031497610.018
peptidyl arginine omega n methylationGO:003524740.018
cellular response to external stimulusGO:00714961110.018
embryonic digestive tract morphogenesisGO:004855720.018
eye developmentGO:0001654420.018
regulation of apoptotic signaling pathwayGO:20012331750.018
stem cell developmentGO:0048864690.018
hippocampus developmentGO:002176610.018
response to alcoholGO:0097305640.018
defense response to fungusGO:005083240.018
regulation of proteolysis involved in cellular protein catabolic processGO:1903050910.017
atp metabolic processGO:00460341760.017
epidermis developmentGO:0008544590.017
cell junction organizationGO:0034330790.017
cellular response to oxygen containing compoundGO:19017012760.017
Rat
negative regulation of histone methylationGO:003106160.017
Mouse
regulation of cellular amino acid metabolic processGO:000652160.017
cytoskeleton dependent cytokinesisGO:0061640220.017
internal protein amino acid acetylationGO:00064751010.017
female gamete generationGO:000729220.017
gonad developmentGO:0008406340.017
sensory organ developmentGO:0007423520.016
regulation of bindingGO:00510981110.016
neurogenesisGO:00220081690.016
Rat
negative regulation of transferase activityGO:00513481240.016
positive regulation of apoptotic signaling pathwayGO:2001235700.016
spindle assemblyGO:0051225290.016
inflammatory responseGO:0006954790.016
embryo developmentGO:00097901230.016
Mouse
negative regulation of cellular component organizationGO:00511292350.016
Mouse
somatic diversification of immunoglobulins involved in immune responseGO:000220830.016
response to fungusGO:000962040.016
carbohydrate derivative biosynthetic processGO:19011372070.016
determination of dorsal ventral asymmetryGO:004826240.016
positive regulation of protein import into nucleusGO:0042307460.016
limbic system developmentGO:002176130.015
negative regulation of growthGO:0045926970.015
mitochondrion organizationGO:00070051560.015
response to organonitrogen compoundGO:00102431560.015
Rat
purine ribonucleoside triphosphate catabolic processGO:00092073910.015
positive regulation of locomotionGO:00400171860.015
gliogenesisGO:0042063210.015
ribonucleotide catabolic processGO:00092614050.015
regulation of intracellular protein transportGO:00331571230.015
regulation of chromosome organizationGO:00330441030.015
Mouse
regulation of cell morphogenesisGO:00226041530.015
positive regulation of secretion by cellGO:19035321080.015
negative regulation of protein phosphorylationGO:00019331400.015
regulation of sequence specific dna binding transcription factor activityGO:00510902110.015
regulation of intrinsic apoptotic signaling pathwayGO:2001242720.015
cellular response to organonitrogen compoundGO:00714171240.015
Rat
endocytosisGO:00068971590.014
dna replicationGO:00062601160.014
receptor mediated endocytosisGO:0006898840.014
peptidyl lysine trimethylationGO:0018023100.014
small molecule biosynthetic processGO:00442831570.014
cellular response to extracellular stimulusGO:0031668720.014
organelle assemblyGO:00709251760.014
camera type eye developmentGO:0043010250.014
regulation of cell divisionGO:00513021160.014
cellular lipid metabolic processGO:00442553030.014
negative regulation of dna metabolic processGO:0051053570.014
response to inorganic substanceGO:00100351270.014
regulation of dna damage response signal transduction by p53 class mediatorGO:0043516200.014
regulation of secretionGO:00510461940.014
negative regulation of cell morphogenesis involved in differentiationGO:0010771240.014
regulation of wnt signaling pathwayGO:00301111230.013
cell cycle g2 m phase transitionGO:0044839430.013
cellular response to vitamin dGO:007130550.013
negative regulation of phosphorus metabolic processGO:00105632670.013
oxidation reduction processGO:00551143960.013
cell morphogenesisGO:00009022960.013
tricarboxylic acid metabolic processGO:007235040.013
intracellular protein transportGO:00068862700.013
nuclear importGO:00511701060.013
eyelid development in camera type eyeGO:006102920.013
multi organism reproductive processGO:0044703540.013
cellular heat acclimationGO:007037030.013
protein polymerizationGO:0051258710.013
positive regulation of cell motilityGO:20001471770.013
negative regulation of muscle organ developmentGO:0048635120.013
regulation of glial cell differentiationGO:004568530.013
brain developmentGO:0007420970.013
Mouse Rat
negative regulation of bindingGO:0051100570.013
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.012
cellular response to peptideGO:1901653590.012
hemopoiesisGO:00300971800.012
Mouse
cellular component morphogenesisGO:00329893140.012
response to caffeineGO:003100030.012
ribonucleoside triphosphate catabolic processGO:00092033910.012
regulation of cellular response to stressGO:00801352440.012
osteoblast differentiationGO:0001649920.012
positive regulation of synaptic transmissionGO:005080640.012
regulation of intracellular transportGO:00323861950.012
positive regulation of cell developmentGO:0010720920.012
Rat
cell morphogenesis involved in differentiationGO:00009041440.012
positive regulation of cellular amino acid metabolic processGO:004576430.012
protein localization to plasma membraneGO:0072659930.012
cellular response to peptide hormone stimulusGO:0071375560.012
apical junction assemblyGO:0043297190.012
lipid oxidationGO:0034440330.012
dna methylation or demethylationGO:0044728190.012
neural tube patterningGO:002153220.012
development of primary sexual characteristicsGO:0045137350.012
regulation of sarcomere organizationGO:006029730.012
positive regulation of cellular amine metabolic processGO:003324070.012
negative regulation of peptidase activityGO:0010466910.012
nucleotide catabolic processGO:00091664080.011
negative regulation of response to external stimulusGO:0032102830.011
negative regulation of protein kinase activityGO:0006469980.011
histone h3 k27 methylationGO:007073460.011
negative regulation of apoptotic signaling pathwayGO:2001234970.011
demethylationGO:0070988370.011
response to ionizing radiationGO:0010212650.011
sex differentiationGO:0007548450.011
signal releaseGO:0023061700.011
regulation of cellular amine metabolic processGO:0033238110.011
purine nucleoside triphosphate metabolic processGO:00091444120.011
generation of precursor metabolites and energyGO:0006091680.011
regulation of protein localization to plasma membraneGO:1903076400.011
convergent extensionGO:006002610.011
negative regulation of protein modification by small protein conjugation or removalGO:1903321410.011
positive regulation of response to external stimulusGO:0032103880.011
intrinsic apoptotic signaling pathwayGO:00971931270.011
fatty acid beta oxidationGO:0006635220.011
secretory granule organizationGO:003336320.011
protein dealkylationGO:0008214170.011
cellular response to alcoholGO:0097306290.011
single organism cellular localizationGO:19025803320.011
negative regulation of cellular amine metabolic processGO:003323930.011
neuromuscular junction developmentGO:000752830.010
muscle tissue developmentGO:0060537620.010
protein import into nucleusGO:00066061040.010
cellular response to cytokine stimulusGO:00713451810.010
single organism membrane fusionGO:0044801370.010
signal transduction by p53 class mediatorGO:0072331720.010
response to extracellular stimulusGO:0009991850.010
regulation of glial cell proliferationGO:006025140.010
notch signaling pathwayGO:0007219310.010
oocyte developmentGO:004859910.010

KDM1A disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:1621670.040
disease of cellular proliferationDOID:145661740.040
organ system cancerDOID:00506861640.015
sensory system diseaseDOID:00501552030.012
retinal degenerationDOID:8466890.012
eye diseaseDOID:56141490.012
nervous system diseaseDOID:8634310.012
retinal diseaseDOID:56791180.012
eye and adnexa diseaseDOID:14921500.012