Homo sapiens

0 known processes

PHLPP1

PH domain and leucine rich repeat protein phosphatase 1

(Aliases: PHLPP,PLEKHE1,SCOP,MGC161555)

PHLPP1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
rho protein signal transductionGO:0007266260.706
glial cell migrationGO:000834740.557
protein modification by small protein removalGO:0070646920.464
establishment or maintenance of apical basal cell polarityGO:003508820.447
protein deubiquitinationGO:0016579790.431
morphogenesis of embryonic epitheliumGO:001633140.384
ras protein signal transductionGO:0007265730.379
nucleoside phosphate catabolic processGO:19012924120.369
skin developmentGO:0043588760.360
embryonic digestive tract morphogenesisGO:004855720.341
morphogenesis of a polarized epitheliumGO:000173830.331
establishment or maintenance of bipolar cell polarityGO:006124520.329
embryonic epithelial tube formationGO:000183840.326
multicellular organismal response to stressGO:003355510.314
establishment or maintenance of epithelial cell apical basal polarityGO:004519710.289
neural tube formationGO:000184130.279
neurotransmitter secretionGO:000726940.277
astrocyte cell migrationGO:004361510.268
behavioral response to ethanolGO:004814920.258
synaptic transmissionGO:0007268610.239
guanosine containing compound metabolic processGO:19010682440.233
inner ear morphogenesisGO:004247240.230
synaptic vesicle endocytosisGO:004848820.225
purine nucleoside triphosphate metabolic processGO:00091444120.217
pharynx developmentGO:006046510.214
positive regulation of nucleotide catabolic processGO:00308131850.212
cell cell signalingGO:00072671550.211
primary neural tube formationGO:001402030.202
establishment of planar polarityGO:000173630.200
nucleotide catabolic processGO:00091664080.193
positive regulation of catabolic processGO:00098963100.189
purine ribonucleotide catabolic processGO:00091544040.183
purine nucleoside triphosphate catabolic processGO:00091463920.179
metencephalon developmentGO:002203720.177
organophosphate catabolic processGO:00464344300.176
positive regulation of gtpase activityGO:00435471660.173
glycosyl compound catabolic processGO:19016584130.169
purine nucleoside catabolic processGO:00061523980.169
nucleoside triphosphate metabolic processGO:00091414220.169
cellular component disassemblyGO:0022411920.166
synaptic vesicle exocytosisGO:001607930.164
ribonucleoside triphosphate metabolic processGO:00091994120.160
purine nucleotide catabolic processGO:00061954050.148
positive regulation of hydrolase activityGO:00513453310.148
purine containing compound catabolic processGO:00725234110.148
ribonucleoside triphosphate catabolic processGO:00092033910.148
single organism cellular localizationGO:19025803320.147
developmental programmed cell deathGO:001062330.147
positive regulation of nucleotide metabolic processGO:00459812300.146
cellular protein complex disassemblyGO:0043624360.144
actin filament based processGO:00300292240.143
establishment of tissue polarityGO:000716430.142
biological adhesionGO:00226103310.138
anatomical structure formation involved in morphogenesisGO:00486462840.136
vesicle mediated transportGO:00161923710.136
positive regulation of purine nucleotide catabolic processGO:00331231850.134
ribonucleotide catabolic processGO:00092614050.134
gtp catabolic processGO:00061842370.130
positive regulation of ras gtpase activityGO:00323201170.130
guanosine containing compound catabolic processGO:19010692390.129
establishment of apical basal cell polarityGO:003508910.126
regulation of gtp catabolic processGO:00331241800.125
hair cell differentiationGO:003531520.125
female gamete generationGO:000729220.124
positive regulation of purine nucleotide metabolic processGO:19005442270.121
positive regulation of cellular catabolic processGO:00313312840.120
neuron differentiationGO:00301821380.120
protein localization to adherens junctionGO:007189620.120
cell adhesionGO:00071553250.117
regulation of homeostatic processGO:00328441210.116
synaptic vesicle recyclingGO:003646530.113
positive regulation of gtp catabolic processGO:00331261660.113
regulation of nucleoside metabolic processGO:00091182090.112
tube closureGO:006060630.109
purine ribonucleoside metabolic processGO:00461284370.109
purine ribonucleoside triphosphate metabolic processGO:00092054110.106
gtp metabolic processGO:00460392390.105
purine ribonucleoside triphosphate catabolic processGO:00092073910.105
intermediate filament cytoskeleton organizationGO:0045104170.103
single organism cell adhesionGO:00986021790.102
regulation of nucleotide catabolic processGO:00308112050.101
purine ribonucleoside catabolic processGO:00461303980.101
fear responseGO:004259600.099
positive regulation of programmed cell deathGO:00430682490.099
single organismal cell cell adhesionGO:00163371480.093
regulation of nucleotide metabolic processGO:00061402690.093
regulation of rho protein signal transductionGO:0035023790.092
regulation of ras protein signal transductionGO:00465781550.091
apoptotic process involved in morphogenesisGO:006056130.089
digestive system developmentGO:0055123750.088
mammary gland morphogenesisGO:006044320.086
positive regulation of nucleoside metabolic processGO:00459791860.085
epithelium developmentGO:00604292270.084
ribonucleoside catabolic processGO:00424544060.084
neural tube closureGO:000184330.083
regulation of cell cycleGO:00517263930.083
regulation of ras gtpase activityGO:00323181280.083
cellular amino acid metabolic processGO:00065201160.083
regulation of purine nucleotide catabolic processGO:00331212050.082
nucleoside triphosphate catabolic processGO:00091433940.081
positive regulation of rac gtpase activityGO:0032855310.080
establishment of monopolar cell polarityGO:006116210.079
cellular homeostasisGO:00197251960.078
protein complex disassemblyGO:0043241520.077
cellular component morphogenesisGO:00329893140.074
positive regulation of rho gtpase activityGO:0032321560.073
positive regulation of cell proliferationGO:00082843010.072
epithelial cell differentiationGO:00308551410.071
behavioral defense responseGO:000220900.071
regulation of rho gtpase activityGO:0032319660.070
central nervous system developmentGO:00074171230.070
Rat
protein dephosphorylationGO:0006470810.068
Rat Fly
regulation of purine nucleotide metabolic processGO:19005422640.068
cell morphogenesisGO:00009022960.068
cell projection organizationGO:00300302520.067
maintenance of cell polarityGO:003001120.067
convergent extension involved in gastrulationGO:006002710.066
regulation of cytoskeleton organizationGO:00514931770.066
secretionGO:00469032540.066
epithelial tube morphogenesisGO:0060562380.066
cell developmentGO:00484683280.066
exocytosisGO:0006887710.066
amine metabolic processGO:0009308440.065
epidermis developmentGO:0008544590.064
positive regulation of cell deathGO:00109422630.063
tube developmentGO:00352951250.062
cell junction organizationGO:0034330790.061
cell cell junction organizationGO:0045216690.059
regulation of mitotic cell cycleGO:00073461890.055
positive regulation of apoptotic processGO:00430652460.054
post embryonic developmentGO:000979120.054
mitotic cell cycleGO:00002783260.052
organ morphogenesisGO:00098871470.052
tube morphogenesisGO:0035239950.052
morphogenesis of an epitheliumGO:0002009600.050
receptor metabolic processGO:0043112810.050
signal releaseGO:0023061700.050
defense responseGO:00069523150.050
microtubule based processGO:00070172100.049
establishment of mitotic spindle orientationGO:000013270.048
microtubule cytoskeleton organizationGO:00002261760.048
regulation of small gtpase mediated signal transductionGO:00510561560.048
intermediate filament based processGO:0045103170.048
behavioral fear responseGO:000166200.048
cellular response to dna damage stimulusGO:00069743790.046
multicellular organismal agingGO:001025930.046
establishment of cell polarityGO:0030010220.046
establishment of organelle localizationGO:0051656590.045
small gtpase mediated signal transductionGO:0007264780.044
chemotaxisGO:00069351570.043
digestive tract developmentGO:0048565750.043
convergent extensionGO:006002610.042
secretion by cellGO:00329402260.041
cell junction assemblyGO:0034329670.041
regulation of cellular component movementGO:00512703340.041
regulation of locomotionGO:00400123290.040
brain developmentGO:0007420970.039
Rat
mitotic cell cycle processGO:19030472860.038
generation of neuronsGO:00486991520.038
regulation of cellular amino acid metabolic processGO:000652160.038
positive regulation of cellular amine metabolic processGO:003324070.038
system processGO:00030083490.037
wound healingGO:00420601150.037
regulation of cell motilityGO:20001452990.037
neurogenesisGO:00220081690.036
locomotory behaviorGO:000762610.036
regulation of anatomical structure morphogenesisGO:00226032860.036
cellular ketone metabolic processGO:0042180800.035
neural nucleus developmentGO:0048857470.035
taxisGO:00423301570.034
cell morphogenesis involved in differentiationGO:00009041440.034
response to woundingGO:00096111680.034
gastrulationGO:0007369510.034
memoryGO:000761330.034
head developmentGO:00603221080.034
Rat
organelle localizationGO:0051640840.033
positive regulation of cell differentiationGO:00455972110.033
positive regulation of cellular component movementGO:00512721810.033
negative regulation of cell cycleGO:00457861930.032
neurological system processGO:00508771630.032
response to alcoholGO:0097305640.032
positive regulation of cellular amino acid metabolic processGO:004576430.031
regulation of cellular ketone metabolic processGO:0010565500.031
cellular lipid metabolic processGO:00442553030.031
nervous system developmentGO:00073992930.031
Rat
gland developmentGO:0048732480.031
cytoplasmic transportGO:00164823790.031
regulation of cellular amine metabolic processGO:0033238110.031
cell fate determinationGO:000170930.031
forebrain developmentGO:0030900260.031
Rat
positive regulation of cellular component organizationGO:00511303760.031
cation transportGO:00068123310.030
protein localization to cell junctionGO:190241430.030
vesicle localizationGO:0051648260.030
oogenesisGO:004847720.030
positive regulation of cell migrationGO:00303351720.030
positive regulation of developmental processGO:00510943140.029
positive regulation of cell motilityGO:20001471770.029
dna repairGO:00062811980.029
negative regulation of multicellular organismal processGO:00512413170.029
determination of adult lifespanGO:000834020.028
dephosphorylationGO:00163112090.028
Rat Fly
regulation of cell migrationGO:00303342890.028
neuron developmentGO:00486661130.028
regulation of protein kinase activityGO:00458592890.028
lipid metabolic processGO:00066293810.028
cellular amine metabolic processGO:0044106410.027
response to oxygen containing compoundGO:19017003690.027
regulation of cell developmentGO:00602841610.027
neuromuscular junction developmentGO:000752830.027
divalent inorganic cation transportGO:00725111580.027
mesendoderm developmentGO:004838210.027
establishment of vesicle localizationGO:0051650230.027
posttranscriptional regulation of gene expressionGO:00106082130.027
regulation of gtpase activityGO:00430871800.027
segmentationGO:003528240.027
histone modificationGO:00165702510.027
cell cell junction assemblyGO:0007043250.026
cardiovascular system developmentGO:00723582620.026
endosomal transportGO:00161971290.026
protein depolymerizationGO:0051261300.026
chromatin organizationGO:00063253510.026
response to radiationGO:00093141510.026
oocyte differentiationGO:000999420.026
regulation of epithelial cell proliferationGO:00506781130.025
protein catabolic processGO:00301633250.025
positive regulation of transportGO:00510503360.025
negative regulation of mitotic cell cycleGO:00459301020.025
reproductive processGO:00224141060.025
cardiac muscle cell contractionGO:008600340.025
negative regulation of phosphorus metabolic processGO:00105632670.025
oocyte developmentGO:004859910.025
metal ion transportGO:00300012720.025
covalent chromatin modificationGO:00165692540.025
regulation of protein transportGO:00512232130.025
negative regulation of protein metabolic processGO:00512483910.024
behaviorGO:00076101120.024
hindbrain developmentGO:003090230.024
endocytosisGO:00068971590.024
intracellular protein transportGO:00068862700.024
cell projection assemblyGO:00300311260.023
negative regulation of notch signaling pathwayGO:0045746100.023
cellular response to growth factor stimulusGO:00713631970.023
epithelial cell developmentGO:0002064340.023
monocarboxylic acid metabolic processGO:00327871850.023
ion transmembrane transportGO:00342203380.023
cellular macromolecule catabolic processGO:00442653800.023
cellular response to endogenous stimulusGO:00714953360.022
receptor recyclingGO:0001881150.022
sensory perceptionGO:00076001030.022
regulation of response to external stimulusGO:00321012220.022
actin filament based movementGO:0030048170.022
negative regulation of catalytic activityGO:00430863350.022
response to growth factorGO:00708482050.021
blood vessel morphogenesisGO:00485141620.021
digestive tract morphogenesisGO:0048546560.021
macromolecular complex disassemblyGO:0032984600.021
embryonic organ developmentGO:0048568360.021
enzyme linked receptor protein signaling pathwayGO:00071673030.021
release of cytoplasmic sequestered nf kappabGO:000858840.021
negative regulation of phosphate metabolic processGO:00459362670.021
regulation of sequence specific dna binding transcription factor activityGO:00510902110.021
positive regulation of immune system processGO:00026842830.021
regenerationGO:003109940.021
negative regulation of cellular amino acid metabolic processGO:004576320.021
regulation of cellular response to stressGO:00801352440.021
gland morphogenesisGO:002261280.021
divalent metal ion transportGO:00708381520.020
regulation of protein localizationGO:00328802960.020
proteolysis involved in cellular protein catabolic processGO:00516032440.020
chemical homeostasisGO:00488783060.020
chromatin modificationGO:00165682980.020
ear developmentGO:0043583140.020
positive regulation of locomotionGO:00400171860.020
negative regulation of transportGO:00510511760.020
blood vessel developmentGO:00015681720.020
activation of ras gtpase activityGO:0032856150.020
hippocampus developmentGO:002176610.020
Rat
angiogenesisGO:00015251470.020
regulation of establishment of protein localizationGO:00702012420.019
somatic stem cell divisionGO:004810310.019
neurotransmitter transportGO:0006836100.019
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.019
positive regulation of cell developmentGO:0010720920.019
vasculature developmentGO:00019441810.019
regulation of cell differentiationGO:00455953930.019
rhythmic behaviorGO:000762220.019
canonical wnt signaling pathwayGO:00600701160.019
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.018
positive regulation of phosphorylationGO:00423273940.018
cell divisionGO:00513011680.018
negative regulation of protein modification processGO:00314002000.018
neural tube developmentGO:002191590.018
negative regulation of developmental processGO:00510932470.018
neuron migrationGO:0001764110.018
embryo developmentGO:00097901230.018
positive regulation of epithelial cell proliferationGO:0050679650.018
negative regulation of programmed cell deathGO:00430693210.018
establishment or maintenance of cell polarityGO:0007163310.018
regulation of cell morphogenesisGO:00226041530.018
small molecule biosynthetic processGO:00442831570.018
regulation of ion transmembrane transportGO:00347651320.018
i kappab kinase nf kappab signalingGO:00072491660.018
epithelial cell proliferationGO:00506731280.018
blastoderm segmentationGO:000735020.017
regulation of receptor recyclingGO:0001919100.017
apoptotic signaling pathwayGO:00971902680.017
spermatid differentiationGO:004851540.017
transmembrane transportGO:00550853990.017
protein targetingGO:00066051870.017
positive regulation of keratinocyte proliferationGO:001083840.017
carbohydrate derivative biosynthetic processGO:19011372070.017
sensory organ developmentGO:0007423520.017
regulation of proteolysisGO:00301622930.017
regulation of dna metabolic processGO:00510521530.017
mammary gland epithelium developmentGO:0061180100.017
regulation of wnt signaling pathwayGO:00301111230.017
nerve developmentGO:002167540.017
thymus developmentGO:004853830.017
negative regulation of cellular protein metabolic processGO:00322693530.017
regulation of intracellular protein transportGO:00331571230.017
peripheral nervous system developmentGO:000742220.017
regulation of immune responseGO:00507762010.017
dna recombinationGO:0006310770.016
wnt signaling pathwayGO:00160551560.016
signal transduction by phosphorylationGO:00230142970.016
organic acid biosynthetic processGO:0016053970.016
ameboidal type cell migrationGO:00016671350.016
embryonic digestive tract developmentGO:0048566100.016
immune responseGO:00069553070.016
epithelium migrationGO:00901321190.016
compound eye developmentGO:004874910.016
establishment of spindle orientationGO:005129490.016
peptidyl tyrosine phosphorylationGO:00181081700.016
regulation of protein ubiquitinationGO:0031396950.016
carboxylic acid biosynthetic processGO:0046394970.016
regulation of canonical wnt signaling pathwayGO:0060828880.016
mapk cascadeGO:00001652880.016
limbic system developmentGO:002176130.016
Rat
reproductive structure developmentGO:0048608550.016
neuroblast proliferationGO:000740540.016
embryonic organ morphogenesisGO:0048562240.016
inner ear developmentGO:004883980.016
single organism reproductive processGO:0044702980.016
protein maturationGO:00516042330.016
positive regulation of protein phosphorylationGO:00019343130.016
regulation of nervous system developmentGO:0051960880.016
response to light stimulusGO:0009416870.015
sensory organ morphogenesisGO:0090596210.015
regulation of membrane potentialGO:0042391950.015
regulation of neuron migrationGO:200122230.015
cellular protein catabolic processGO:00442572610.015
positive regulation of response to external stimulusGO:0032103880.015
branching involved in salivary gland morphogenesisGO:006044510.015
adult locomotory behaviorGO:000834410.015
salivary gland morphogenesisGO:000743540.015
ear morphogenesisGO:004247170.015
positive regulation of cytoplasmic transportGO:1903651820.015
response to abiotic stimulusGO:00096283360.015
negative regulation of apoptotic processGO:00430663160.015
positive regulation of insulin like growth factor receptor signaling pathwayGO:004356840.015
spermatid developmentGO:000728640.015
negative regulation of cell proliferationGO:00082852280.015
anterior posterior axis specificationGO:000994820.015
hemopoiesisGO:00300971800.015
endomembrane system organizationGO:00102561960.015
circulatory system developmentGO:00723592620.015
carbohydrate metabolic processGO:00059752070.015
stem cell divisionGO:001714520.015
actin mediated cell contractionGO:0070252120.015
nitrogen compound transportGO:00717051910.015
hematopoietic or lymphoid organ developmentGO:00485341860.015
regulation of cytokine productionGO:00018172320.015
cell projection morphogenesisGO:00488581290.015
innate immune responseGO:00450871780.015
cellular response to abiotic stimulusGO:00712141170.015
organelle assemblyGO:00709251760.015
regulation of endopeptidase activityGO:00525481700.015
response to external biotic stimulusGO:00432072610.015
proteasomal protein catabolic processGO:00104981760.014
pituitary gland developmentGO:002198320.014
regulation of apoptotic signaling pathwayGO:20012331750.014
circadian behaviorGO:004851220.014
detection of stimulusGO:0051606850.014
gastrulation with mouth forming secondGO:000170210.014
regulation of neurotransmitter levelsGO:0001505150.014
protein monoubiquitinationGO:0006513390.014
matingGO:000761810.014
rna splicingGO:00083801310.014
regulation of neural precursor cell proliferationGO:200017740.014
tissue migrationGO:00901301190.014
sensory perception of light stimulusGO:0050953350.014
single organism carbohydrate metabolic processGO:00447231930.014
cell morphogenesis involved in neuron differentiationGO:0048667440.014
mrna metabolic processGO:00160711750.014
fatty acid metabolic processGO:00066311150.014
vesicle targetingGO:000690370.014
epithelial cell migrationGO:00106311190.014
patterning of blood vesselsGO:000156920.014
somitogenesisGO:000175620.014
negative regulation of cell deathGO:00605483450.014
regulation of protein modification by small protein conjugation or removalGO:19033201070.014
negative regulation of cellular component organizationGO:00511292350.014
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.014
cellular response to oxygen containing compoundGO:19017012760.014
cytokinesisGO:0000910960.014
regulation of ion transportGO:00432691890.014
positive regulation of cell cycleGO:00457871400.014
positive regulation of cellular component biogenesisGO:00440891580.014
leukocyte activationGO:00453211640.014
response to biotic stimulusGO:00096072760.014
single organism membrane organizationGO:00448022680.014
response to lipidGO:00339932060.014
cell activationGO:00017752130.014
organ formationGO:004864530.014
long term memoryGO:000761620.014
cytokine productionGO:00018162470.014
protein modification by small protein conjugationGO:00324463420.014
regulation of protein catabolic processGO:00421761550.014
ectoderm developmentGO:000739830.013
protein localization to nucleusGO:00345041360.013
lipid biosynthetic processGO:00086101770.013
organic hydroxy compound metabolic processGO:19016151470.013
cerebellum developmentGO:002154920.013
regulation of glial cell proliferationGO:006025140.013
tripartite regional subdivisionGO:000735120.013
cell migration involved in gastrulationGO:004207410.013
nucleoside catabolic processGO:00091644080.013
cellular protein complex assemblyGO:00436231880.013
reactive oxygen species biosynthetic processGO:190340940.013
membrane organizationGO:00610242920.013
response to drugGO:0042493810.013
cellular ion homeostasisGO:00068731680.013
photoreceptor cell differentiationGO:004653020.013
neuroblast divisionGO:005505710.013
phototransductionGO:000760230.013
notch signaling pathwayGO:0007219310.013
positive regulation of protein transportGO:00512221350.013
protein ubiquitinationGO:00165673140.013
response to other organismGO:00517072610.013
protein autophosphorylationGO:00467771230.013
regulation of cell adhesionGO:00301551660.013
purine nucleoside monophosphate metabolic processGO:00091261860.013
response to decreased oxygen levelsGO:0036293960.013
anion transportGO:00068201610.013
melanin metabolic processGO:000658210.013
positive regulation of synaptic transmissionGO:005080640.013
second messenger mediated signalingGO:0019932780.013
protein oligomerizationGO:00512591730.013
negative regulation of hydrolase activityGO:00513461820.013
mammary gland developmentGO:0030879170.013
epithelial tube branching involved in lung morphogenesisGO:006044140.013
regulation of peptidase activityGO:00525471800.013
sensory perception of painGO:001923340.013
response to oxygen levelsGO:00704821000.013
negative regulation of intracellular signal transductionGO:19025321830.012
Rat
cellular macromolecular complex assemblyGO:00346223240.012
regulation of neurogenesisGO:0050767820.012
modification dependent macromolecule catabolic processGO:00436322120.012
ion homeostasisGO:00508012300.012
maintenance of locationGO:00512351120.012
motor neuron axon guidanceGO:000804520.012
secondary metabolite biosynthetic processGO:004455020.012
blastocyst developmentGO:000182430.012
inorganic ion transmembrane transportGO:00986602310.012
protein processingGO:00164852260.012
associative learningGO:000830610.012
cation homeostasisGO:00550801890.012
negative regulation of growthGO:0045926970.012
positive regulation of proteolysisGO:00458621420.012
catagenGO:004263730.012
positive regulation of intracellular protein transportGO:0090316760.012
response to organic cyclic compoundGO:00140702040.012
regulation of cell cycle processGO:00105642660.012
regulation of epithelial cell migrationGO:0010632930.012
regulation of odontogenesisGO:004248140.012
regulation of cysteine type endopeptidase activityGO:20001161270.012
cation transmembrane transportGO:00986552380.012
reproductive system developmentGO:0061458560.012
reactive oxygen species metabolic processGO:0072593750.012
regulation of i kappab kinase nf kappab signalingGO:00431221620.012
positive regulation of gliogenesisGO:001401540.012

PHLPP1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
organ system cancerDOID:00506861640.025
cancerDOID:1621670.025
disease of cellular proliferationDOID:145661740.025
sensory system diseaseDOID:00501552030.024
nervous system diseaseDOID:8634310.024
disease of metabolismDOID:00146672950.023
musculoskeletal system diseaseDOID:172230.019
central nervous system diseaseDOID:3311860.015
inherited metabolic disorderDOID:6552420.015
eye and adnexa diseaseDOID:14921500.014
eye diseaseDOID:56141490.014
connective tissue diseaseDOID:651090.013