Homo sapiens

61 known processes

SHARPIN

SHANK-associated RH domain interactor

(Aliases: SIPL1,DKFZp434N1923)

SHARPIN biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
single organism cellular localizationGO:19025803320.116
regulation of cd40 signaling pathwayGO:200034830.112
regulation of protein localizationGO:00328802960.112
oogenesisGO:004847720.097
immune responseGO:00069553070.096
Human
negative regulation of programmed cell deathGO:00430693210.092
apoptotic signaling pathwayGO:00971902680.091
positive regulation of programmed cell deathGO:00430682490.087
nitrogen compound transportGO:00717051910.085
female gamete generationGO:000729220.084
regulation of cellular amine metabolic processGO:0033238110.084
positive regulation of cell deathGO:00109422630.074
response to axon injuryGO:004867810.073
positive regulation of immune responseGO:00507781590.073
Human
positive regulation of cellular amino acid metabolic processGO:004576430.067
regulation of extrinsic apoptotic signaling pathwayGO:2001236850.064
cellular amino acid metabolic processGO:00065201160.064
positive regulation of cellular amine metabolic processGO:003324070.064
regulation of establishment of protein localizationGO:00702012420.062
positive regulation of apoptotic processGO:00430652460.062
regulation of cellular amino acid metabolic processGO:000652160.059
cellular ketone metabolic processGO:0042180800.058
protein targetingGO:00066051870.057
i kappab kinase nf kappab signalingGO:00072491660.057
cellular amine metabolic processGO:0044106410.056
protein catabolic processGO:00301633250.055
Human
regulation of cellular ketone metabolic processGO:0010565500.052
modification dependent macromolecule catabolic processGO:00436322120.051
Human
post embryonic developmentGO:000979120.050
positive regulation of immune system processGO:00026842830.050
Human
regulation of immune responseGO:00507762010.049
Human
response to oxygen containing compoundGO:19017003690.049
modification dependent protein catabolic processGO:00199412090.048
Human
negative regulation of cell proliferationGO:00082852280.047
behavioral response to ethanolGO:004814920.047
cellular response to external stimulusGO:00714961110.046
dephosphorylationGO:00163112090.044
carbohydrate derivative biosynthetic processGO:19011372070.043
epithelium developmentGO:00604292270.041
Mouse
oocyte developmentGO:004859910.041
amine metabolic processGO:0009308440.040
regulation of necroptotic processGO:006054470.040
regulation of cellular component biogenesisGO:00440872810.039
segmentationGO:003528240.039
neuromuscular junction developmentGO:000752830.038
peptidyl serine phosphorylationGO:00181051010.038
response to organic cyclic compoundGO:00140702040.038
positive regulation of phagocytosis engulfmentGO:006010010.038
response to decreased oxygen levelsGO:0036293960.037
regulation of sequence specific dna binding transcription factor activityGO:00510902110.036
Human
cytoplasmic transportGO:00164823790.036
positive regulation of developmental processGO:00510943140.036
positive regulation of nf kappab transcription factor activityGO:0051092810.036
Human
regulation of transmission of nerve impulseGO:005196920.036
oocyte differentiationGO:000999420.035
regulation of peptidase activityGO:00525471800.035
sensory perception of smellGO:000760820.035
epithelium migrationGO:00901321190.034
regulation of protein modification by small protein conjugation or removalGO:19033201070.033
proteolysis involved in cellular protein catabolic processGO:00516032440.033
Human
cellular response to cytokine stimulusGO:00713451810.033
negative regulation of protein metabolic processGO:00512483910.033
programmed necrotic cell deathGO:0097300180.032
cell morphogenesisGO:00009022960.032
protein importGO:00170381300.031
ectoderm developmentGO:000739830.031
regulation of apoptotic signaling pathwayGO:20012331750.031
cellular response to tumor necrosis factorGO:0071356630.030
regulation of endopeptidase activityGO:00525481700.030
embryonic morphogenesisGO:0048598850.029
response to hypoxiaGO:0001666960.029
regulation of protein transportGO:00512232130.029
positive regulation of transportGO:00510503360.029
immune response activating signal transductionGO:0002757900.029
Human
negative regulation of cellular protein metabolic processGO:00322693530.028
cellular protein catabolic processGO:00442572610.028
Human
regulation of i kappab kinase nf kappab signalingGO:00431221620.028
response to hormoneGO:00097251750.027
response to abiotic stimulusGO:00096283360.027
regulation of protein catabolic processGO:00421761550.027
intracellular protein transportGO:00068862700.027
positive regulation of protein transportGO:00512221350.026
protein localization to organelleGO:00333652800.026
regulation of cytoplasmic transportGO:19036491490.026
positive regulation of protein phosphorylationGO:00019343130.026
regulation of protein ubiquitinationGO:0031396950.026
negative regulation of sequence specific dna binding transcription factor activityGO:0043433890.026
Human
regulation of protein bindingGO:0043393660.026
peptidyl tyrosine phosphorylationGO:00181081700.025
single organism membrane organizationGO:00448022680.025
negative regulation of cellular component organizationGO:00511292350.025
vesicle mediated transportGO:00161923710.025
positive regulation of hydrolase activityGO:00513453310.025
membrane organizationGO:00610242920.025
response to nutrient levelsGO:0031667810.025
response to extracellular stimulusGO:0009991850.025
negative regulation of multicellular organismal processGO:00512413170.025
protein targeting to nucleusGO:00447441040.025
cell activationGO:00017752130.025
post embryonic organ developmentGO:004856910.024
cellular response to growth factor stimulusGO:00713631970.024
regulation of smooth muscle cell proliferationGO:0048660280.024
ubiquitin dependent protein catabolic processGO:00065112060.024
Human
protein modification by small protein conjugationGO:00324463420.024
regulation of cytokine productionGO:00018172320.024
nuclear transportGO:00511691790.024
regulation of anatomical structure morphogenesisGO:00226032860.024
regulation of phagocytosis engulfmentGO:006009920.024
regulation of intracellular protein transportGO:00331571230.024
regulation of bindingGO:00510981110.023
establishment of protein localization to organelleGO:00725941720.023
cellular response to lipidGO:00713961270.023
response to drugGO:0042493810.023
cell growthGO:00160491600.023
muscle contractionGO:0006936730.023
response to oxygen levelsGO:00704821000.022
positive regulation of cellular component biogenesisGO:00440891580.022
pericardium developmentGO:006003920.022
regulation of dephosphorylationGO:0035303960.022
memoryGO:000761330.022
positive regulation of phosphorylationGO:00423273940.022
cellular lipid metabolic processGO:00442553030.022
negative regulation of transcription from rna polymerase iii promoterGO:001648030.022
regulation of phosphatase activityGO:0010921810.021
nuclear importGO:00511701060.021
actin filament organizationGO:00070151280.021
protein localization to nucleusGO:00345041360.021
reactive nitrogen species metabolic processGO:200105730.021
lipid metabolic processGO:00066293810.021
immune effector processGO:00022521590.021
positive regulation of cell proliferationGO:00082843010.021
biological adhesionGO:00226103310.021
regulation of transcription factor import into nucleusGO:0042990390.021
interspecies interaction between organismsGO:00444191560.021
protein ubiquitinationGO:00165673140.021
positive regulation of extrinsic apoptotic signaling pathwayGO:2001238260.021
immune response activating cell surface receptor signaling pathwayGO:0002429450.021
Human
glycerolipid metabolic processGO:00464861070.020
cellular macromolecule catabolic processGO:00442653800.020
Human
hypotonic responseGO:000697120.020
cytokine mediated signaling pathwayGO:00192211090.020
wnt signaling pathwayGO:00160551560.020
negative regulation of developmental processGO:00510932470.020
peptidyl tyrosine modificationGO:00182121700.020
extrinsic apoptotic signaling pathwayGO:00971911190.020
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.020
Human
glycoprotein metabolic processGO:00091001100.020
endocytosisGO:00068971590.020
cell projection organizationGO:00300302520.020
carbohydrate metabolic processGO:00059752070.020
peptidyl serine modificationGO:00182091060.020
negative regulation of apoptotic processGO:00430663160.019
positive regulation of cellular component organizationGO:00511303760.019
response to growth factorGO:00708482050.019
amide transportGO:0042886760.019
regulation of cell cycleGO:00517263930.019
positive regulation of peptidyl tyrosine phosphorylationGO:0050731850.019
protein polyubiquitinationGO:00002091100.019
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280690.019
establishment of protein localization to membraneGO:00901501210.019
regulation of cytokine mediated signaling pathwayGO:0001959410.019
positive regulation of intracellular protein transportGO:0090316760.019
negative regulation of cell deathGO:00605483450.019
protein import into nucleusGO:00066061040.018
single organismal cell cell adhesionGO:00163371480.018
negative regulation of bindingGO:0051100570.018
protein localization to membraneGO:00726571600.018
regulation of intracellular transportGO:00323861950.018
protein maturationGO:00516042330.018
regulation of wnt signaling pathwayGO:00301111230.018
nucleocytoplasmic transportGO:00069131760.018
positive regulation of defense responseGO:0031349870.018
cellular component morphogenesisGO:00329893140.018
cellular response to endogenous stimulusGO:00714953360.018
endomembrane system organizationGO:00102561960.018
immune response regulating signaling pathwayGO:0002764970.018
Human
negative regulation of growthGO:0045926970.018
positive regulation of catabolic processGO:00098963100.018
behaviorGO:00076101120.018
organophosphate biosynthetic processGO:00904071630.018
negative regulation of nf kappab transcription factor activityGO:0032088510.018
Human
cellular response to nutrient levelsGO:0031669690.018
regulation of cell morphogenesisGO:00226041530.018
positive regulation of cellular component movementGO:00512721810.018
viral life cycleGO:00190581320.018
cellular response to abiotic stimulusGO:00712141170.017
locomotory behaviorGO:000762610.017
cell substrate adhesionGO:00315891320.017
tissue migrationGO:00901301190.017
multicellular organismal agingGO:001025930.017
cell part morphogenesisGO:00329901370.017
nucleoside phosphate biosynthetic processGO:19012931090.017
regulation of locomotionGO:00400123290.017
detection of mechanical stimulus involved in sensory perceptionGO:005097410.017
innate immune responseGO:00450871780.017
sensory perceptionGO:00076001030.017
regulation of peptide transportGO:0090087620.017
cellular response to dna damage stimulusGO:00069743790.017
proteasomal protein catabolic processGO:00104981760.017
Human
cellular response to hormone stimulusGO:00328701250.017
protein processingGO:00164852260.016
t cell receptor signaling pathwayGO:0050852210.016
Human
positive regulation of cell adhesionGO:0045785840.016
renal system processGO:0003014250.016
lymphocyte activationGO:00466491330.016
regulation of cell differentiationGO:00455953930.016
defense response to fungusGO:005083240.016
t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cellGO:000229140.016
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.016
negative regulation of phosphorus metabolic processGO:00105632670.016
single organism cell adhesionGO:00986021790.016
positive regulation of cellular catabolic processGO:00313312840.016
cell adhesionGO:00071553250.016
zymogen activationGO:0031638700.016
muscle system processGO:0003012810.016
cytokine productionGO:00018162470.016
rna processingGO:00063962550.016
actin cytoskeleton organizationGO:00300362070.016
regulation of protein localization to nucleusGO:1900180850.016
detection of mechanical stimulusGO:005098240.016
mitotic cell cycleGO:00002783260.016
negative regulation of catalytic activityGO:00430863350.015
cellular response to extracellular stimulusGO:0031668720.015
regulation of transforming growth factor beta receptor signaling pathwayGO:0017015480.015
detection of stimulusGO:0051606850.015
hindbrain developmentGO:003090230.015
negative regulation of protein bindingGO:0032091350.015
regulation of behaviorGO:0050795820.015
negative regulation of locomotionGO:00400131180.015
blastoderm segmentationGO:000735020.015
response to woundingGO:00096111680.015
Mouse
cellular response to biotic stimulusGO:0071216710.015
negative regulation of protein modification processGO:00314002000.015
intrinsic apoptotic signaling pathwayGO:00971931270.015
regulation of cellular response to stressGO:00801352440.015
translationGO:00064121320.015
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.015
Human
cellular response to transforming growth factor beta stimulusGO:0071560940.014
cell projection morphogenesisGO:00488581290.014
nucleoside triphosphate metabolic processGO:00091414220.014
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.014
system processGO:00030083490.014
transcription factor import into nucleusGO:0042991400.014
negative regulation of cell cycleGO:00457861930.014
negative regulation of cellular amino acid metabolic processGO:004576320.014
positive regulation of locomotionGO:00400171860.014
activation of immune responseGO:00022531140.014
Human
cellular extravasationGO:0045123210.014
regenerationGO:003109940.014
regulation of response to external stimulusGO:00321012220.014
Mouse
positive regulation of cysteine type endopeptidase activityGO:2001056790.014
response to external biotic stimulusGO:00432072610.014
nephron developmentGO:0072006300.014
antigen receptor mediated signaling pathwayGO:0050851380.014
Human
phosphatidylinositol metabolic processGO:0046488530.014
enzyme linked receptor protein signaling pathwayGO:00071673030.014
taxisGO:00423301570.014
cell cycle phase transitionGO:00447701730.014
organ morphogenesisGO:00098871470.014
intracellular receptor signaling pathwayGO:00305221040.014
regulation of response to cytokine stimulusGO:0060759460.014
peripheral nervous system developmentGO:000742220.014
positive regulation of intracellular transportGO:00323881040.014
single organism nuclear importGO:19025931040.014
purine nucleoside triphosphate metabolic processGO:00091444120.013
positive regulation of transcription factor import into nucleusGO:0042993250.013
ameboidal type cell migrationGO:00016671350.013
necrotic cell deathGO:0070265210.013
regulation of cellular response to growth factor stimulusGO:0090287760.013
ion transmembrane transportGO:00342203380.013
regulation of mitotic cell cycleGO:00073461890.013
plasma membrane organizationGO:00070091150.013
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.013
tissue morphogenesisGO:0048729960.013
sensory perception of painGO:001923340.013
response to organonitrogen compoundGO:00102431560.013
response to oxidative stressGO:00069791210.013
regulation of growthGO:00400081650.013
tube developmentGO:00352951250.013
determination of adult lifespanGO:000834020.013
negative regulation of protein ubiquitinationGO:0031397350.013
positive regulation of apoptotic signaling pathwayGO:2001235700.013
regulation of synaptic plasticityGO:004816730.013
negative regulation of phosphate metabolic processGO:00459362670.013
regulation of cytoskeleton organizationGO:00514931770.013
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.013
purine ribonucleoside triphosphate catabolic processGO:00092073910.013
response to lipidGO:00339932060.013
cd40 signaling pathwayGO:002303530.013
nervous system developmentGO:00073992930.013
Rat
response to acid chemicalGO:0001101660.013
positive regulation of nucleocytoplasmic transportGO:0046824540.012
hemopoiesisGO:00300971800.012
negative regulation of protein phosphorylationGO:00019331400.012
anterior posterior axis specificationGO:000994820.012
purine containing compound catabolic processGO:00725234110.012
chemotaxisGO:00069351570.012
actin filament based processGO:00300292240.012
regulation of protein import into nucleusGO:0042306780.012
positive regulation of protein complex assemblyGO:0031334860.012
regulation of reactive oxygen species biosynthetic processGO:190342630.012
regulation of cysteine type endopeptidase activityGO:20001161270.012
epithelial cell migrationGO:00106311190.012
purine nucleoside catabolic processGO:00061523980.012
posttranscriptional regulation of gene expressionGO:00106082130.012
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathwayGO:0043162100.012
leukocyte migrationGO:00509001070.012
skeletal system developmentGO:0001501790.012
purine ribonucleoside monophosphate metabolic processGO:00091671860.012
regulation of peptidyl tyrosine phosphorylationGO:00507301080.012
liposaccharide metabolic processGO:1903509270.012
mitotic cell cycle processGO:19030472860.012
positive regulation of response to external stimulusGO:0032103880.012
necroptotic processGO:0070266160.012
epithelial cell differentiationGO:00308551410.012
Mouse
somatic muscle developmentGO:000752510.012
neuron differentiationGO:00301821380.012
spermatid differentiationGO:004851540.012
glycoprotein biosynthetic processGO:0009101910.012
cellular cation homeostasisGO:00300031630.012
anterior posterior axis specification embryoGO:000859520.012
regulation of cellular component movementGO:00512703340.012
glycerolipid biosynthetic processGO:0045017510.012
response to fungusGO:000962040.012
wound healingGO:00420601150.011
cellular response to organic cyclic compoundGO:00714071270.011
response to activityGO:001482300.011
protein localization to plasma membraneGO:0072659930.011
hematopoietic or lymphoid organ developmentGO:00485341860.011
growthGO:00400072020.011
nucleic acid phosphodiester bond hydrolysisGO:00903051020.011
phospholipid metabolic processGO:0006644990.011
positive regulation of transferase activityGO:00513472270.011
compound eye developmentGO:004874910.011
nucleotide biosynthetic processGO:00091651090.011
activation of cysteine type endopeptidase activity involved in apoptotic processGO:0006919490.011
embryo developmentGO:00097901230.011
response to other organismGO:00517072610.011
positive regulation of cell motilityGO:20001471770.011
regulation of cell adhesionGO:00301551660.011
syncytium formation by plasma membrane fusionGO:000076820.011
tripartite regional subdivisionGO:000735120.011
regulation of nucleocytoplasmic transportGO:0046822980.011
response to nutrientGO:0007584200.011
ribonucleoside triphosphate catabolic processGO:00092033910.011
morphogenesis of embryonic epitheliumGO:001633140.011
regulation of response to woundingGO:19030341010.011
Mouse
negative regulation of protein modification by small protein conjugation or removalGO:1903321410.011
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.011
leukocyte activationGO:00453211640.011
cell morphogenesis involved in differentiationGO:00009041440.011
regulation of protein serine threonine kinase activityGO:00719001790.011
regulation of tumor necrosis factor mediated signaling pathwayGO:0010803120.011
cellular response to oxygen containing compoundGO:19017012760.010
kidney developmentGO:0001822530.010
regulation of bmp signaling pathwayGO:0030510270.010
regulation of actin filament based processGO:00329701410.010
epithelial cell proliferationGO:00506731280.010
cell matrix adhesionGO:0007160850.010
negative regulation of intracellular signal transductionGO:19025321830.010
negative regulation of catabolic processGO:00098951040.010
positive regulation of reactive oxygen species biosynthetic processGO:190342820.010
chromatin organizationGO:00063253510.010
regulation of kinase activityGO:00435493140.010
regulation of mitotic cell cycle phase transitionGO:19019901180.010
bmp signaling pathwayGO:0030509490.010
positive regulation of peptidase activityGO:0010952880.010
negative regulation of cell motilityGO:20001461040.010

SHARPIN disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:172230.023
connective tissue diseaseDOID:651090.023
nervous system diseaseDOID:8634310.015
central nervous system diseaseDOID:3311860.015
disease of metabolismDOID:00146672950.015
organ system cancerDOID:00506861640.013
cancerDOID:1621670.013
disease of cellular proliferationDOID:145661740.013
integumentary system diseaseDOID:16430.012
skin diseaseDOID:37330.012
immune system diseaseDOID:29141550.011