Homo sapiens

5 known processes

SRD5A1

steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)

(Aliases: S5AR 1)

SRD5A1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular amino acid metabolic processGO:00065201160.076
post embryonic developmentGO:000979120.069
amine metabolic processGO:0009308440.058
cellular ketone metabolic processGO:0042180800.052
Rat
cellular amine metabolic processGO:0044106410.051
purine ribonucleoside metabolic processGO:00461284370.048
nucleoside triphosphate metabolic processGO:00091414220.047
lipid metabolic processGO:00066293810.046
Rat
regulation of cellular amino acid metabolic processGO:000652160.044
regulation of cellular amine metabolic processGO:0033238110.044
transmembrane transportGO:00550853990.043
ras protein signal transductionGO:0007265730.043
ribonucleoside triphosphate metabolic processGO:00091994120.042
female gamete generationGO:000729220.042
regulation of cellular ketone metabolic processGO:0010565500.041
nucleoside catabolic processGO:00091644080.041
multicellular organismal agingGO:001025930.041
cellular lipid metabolic processGO:00442553030.041
Rat
determination of adult lifespanGO:000834020.040
organophosphate catabolic processGO:00464344300.039
ion transmembrane transportGO:00342203380.038
oogenesisGO:004847720.038
glycosyl compound catabolic processGO:19016584130.038
purine nucleotide catabolic processGO:00061954050.038
ribonucleotide catabolic processGO:00092614050.037
purine ribonucleoside triphosphate metabolic processGO:00092054110.037
nucleoside phosphate catabolic processGO:19012924120.037
locomotory behaviorGO:000762610.037
organonitrogen compound biosynthetic processGO:19015662000.036
small gtpase mediated signal transductionGO:0007264780.036
purine nucleoside triphosphate metabolic processGO:00091444120.035
nucleoside triphosphate catabolic processGO:00091433940.035
positive regulation of cellular amino acid metabolic processGO:004576430.035
chemical homeostasisGO:00488783060.035
ribonucleoside catabolic processGO:00424544060.034
purine nucleoside catabolic processGO:00061523980.034
purine ribonucleotide catabolic processGO:00091544040.034
purine containing compound catabolic processGO:00725234110.034
nucleotide catabolic processGO:00091664080.034
purine ribonucleoside catabolic processGO:00461303980.034
ribonucleoside triphosphate catabolic processGO:00092033910.034
purine ribonucleoside triphosphate catabolic processGO:00092073910.033
negative regulation of protein metabolic processGO:00512483910.033
oxidation reduction processGO:00551143960.033
positive regulation of cellular amine metabolic processGO:003324070.033
cytoplasmic transportGO:00164823790.032
regulation of nucleotide metabolic processGO:00061402690.032
positive regulation of hydrolase activityGO:00513453310.031
negative regulation of catalytic activityGO:00430863350.031
neuromuscular junction developmentGO:000752830.031
cation transportGO:00068123310.031
vesicle mediated transportGO:00161923710.030
purine nucleoside triphosphate catabolic processGO:00091463920.030
immune responseGO:00069553070.030
carbohydrate derivative biosynthetic processGO:19011372070.030
response to oxygen containing compoundGO:19017003690.030
Rat
gtp metabolic processGO:00460392390.029
negative regulation of cellular protein metabolic processGO:00322693530.029
single organism membrane organizationGO:00448022680.029
regulation of cell differentiationGO:00455953930.029
biological adhesionGO:00226103310.029
response to abiotic stimulusGO:00096283360.029
positive regulation of catabolic processGO:00098963100.029
ion homeostasisGO:00508012300.028
inorganic ion transmembrane transportGO:00986602310.028
positive regulation of cellular component organizationGO:00511303760.028
rho protein signal transductionGO:0007266260.028
small molecule biosynthetic processGO:00442831570.028
gtp catabolic processGO:00061842370.028
actin filament based processGO:00300292240.028
regulation of purine nucleotide metabolic processGO:19005422640.028
membrane organizationGO:00610242920.027
regulation of transferase activityGO:00513383550.027
positive regulation of transportGO:00510503360.027
segmentationGO:003528240.027
cell adhesionGO:00071553250.027
cellular homeostasisGO:00197251960.027
organophosphate biosynthetic processGO:00904071630.027
defense responseGO:00069523150.027
cation transmembrane transportGO:00986552380.027
secretionGO:00469032540.027
system processGO:00030083490.026
carbohydrate metabolic processGO:00059752070.026
negative regulation of phosphate metabolic processGO:00459362670.026
nervous system developmentGO:00073992930.025
Rat
secretion by cellGO:00329402260.025
single organism cellular localizationGO:19025803320.025
cell morphogenesisGO:00009022960.025
oocyte differentiationGO:000999420.025
positive regulation of purine nucleotide metabolic processGO:19005442270.025
regulation of cell cycleGO:00517263930.025
positive regulation of cellular catabolic processGO:00313312840.025
positive regulation of nucleotide metabolic processGO:00459812300.024
cell developmentGO:00484683280.024
cellular component morphogenesisGO:00329893140.024
negative regulation of phosphorus metabolic processGO:00105632670.024
regulation of protein localizationGO:00328802960.024
metal ion transportGO:00300012720.023
single organism carbohydrate metabolic processGO:00447231930.023
regulation of protein kinase activityGO:00458592890.023
monocarboxylic acid metabolic processGO:00327871850.023
guanosine containing compound metabolic processGO:19010682440.023
apoptotic signaling pathwayGO:00971902680.023
regulation of cellular component biogenesisGO:00440872810.023
regenerationGO:003109940.023
positive regulation of phosphorylationGO:00423273940.023
innate immune responseGO:00450871780.023
regulation of cellular component movementGO:00512703340.023
regulation of nucleoside metabolic processGO:00091182090.023
morphogenesis of embryonic epitheliumGO:001633140.023
negative regulation of cell deathGO:00605483450.023
endomembrane system organizationGO:00102561960.022
cell projection organizationGO:00300302520.022
memoryGO:000761330.022
inorganic cation transmembrane transportGO:00986621940.022
regulation of anatomical structure morphogenesisGO:00226032860.022
positive regulation of purine nucleotide catabolic processGO:00331231850.022
protein maturationGO:00516042330.022
cellular response to dna damage stimulusGO:00069743790.022
oocyte developmentGO:004859910.022
blastoderm segmentationGO:000735020.022
guanosine containing compound catabolic processGO:19010692390.022
cation homeostasisGO:00550801890.022
response to other organismGO:00517072610.022
response to biotic stimulusGO:00096072760.022
regulation of purine nucleotide catabolic processGO:00331212050.022
negative regulation of cellular component organizationGO:00511292350.021
negative regulation of multicellular organismal processGO:00512413170.021
dephosphorylationGO:00163112090.021
regulation of nucleotide catabolic processGO:00308112050.021
regulation of kinase activityGO:00435493140.021
cellular macromolecular complex assemblyGO:00346223240.021
regulation of cellular response to stressGO:00801352440.021
cardiac muscle cell contractionGO:008600340.021
negative regulation of programmed cell deathGO:00430693210.021
regulation of secretionGO:00510461940.021
regulation of proteolysisGO:00301622930.021
mitotic cell cycleGO:00002783260.021
regulation of cell cycle processGO:00105642660.021
anterior posterior axis specificationGO:000994820.021
positive regulation of developmental processGO:00510943140.021
cellular chemical homeostasisGO:00550821800.021
response to external biotic stimulusGO:00432072610.021
positive regulation of nucleoside metabolic processGO:00459791860.020
regulation of locomotionGO:00400123290.020
protein localization to organelleGO:00333652800.020
protein catabolic processGO:00301633250.020
protein processingGO:00164852260.020
hindbrain developmentGO:003090230.020
regulation of synaptic plasticityGO:004816730.020
signal transduction by phosphorylationGO:00230142970.020
organic hydroxy compound metabolic processGO:19016151470.020
Rat
cellular macromolecule catabolic processGO:00442653800.020
metal ion homeostasisGO:00550651690.020
cellular response to oxygen containing compoundGO:19017012760.020
Rat
negative regulation of cellular amine metabolic processGO:003323930.019
carboxylic acid biosynthetic processGO:0046394970.019
regulation of cell migrationGO:00303342890.019
maintenance of locationGO:00512351120.019
mitotic cell cycle processGO:19030472860.019
lipid biosynthetic processGO:00086101770.019
Rat
negative regulation of apoptotic processGO:00430663160.019
regulation of cell motilityGO:20001452990.019
positive regulation of nucleotide catabolic processGO:00308131850.019
regulation of establishment of protein localizationGO:00702012420.019
regulation of gtp catabolic processGO:00331241800.019
regulation of gtpase activityGO:00430871800.019
adult locomotory behaviorGO:000834410.019
negative regulation of hydrolase activityGO:00513461820.019
cellular cation homeostasisGO:00300031630.019
cellular protein complex assemblyGO:00436231880.019
intracellular protein transportGO:00068862700.019
mapk cascadeGO:00001652880.019
regulation of cytoskeleton organizationGO:00514931770.019
peripheral nervous system developmentGO:000742220.019
regulation of response to external stimulusGO:00321012220.018
cellular ion homeostasisGO:00068731680.018
regulation of secretion by cellGO:19035301770.018
cellular response to endogenous stimulusGO:00714953360.018
Rat
reactive oxygen species biosynthetic processGO:190340940.018
embryonic epithelial tube formationGO:000183840.018
positive regulation of synaptic transmissionGO:005080640.018
anterior posterior axis specification embryoGO:000859520.018
anion transportGO:00068201610.018
nitrogen compound transportGO:00717051910.018
cellular metal ion homeostasisGO:00068751460.018
protein ubiquitinationGO:00165673140.018
positive regulation of protein phosphorylationGO:00019343130.018
positive regulation of cell deathGO:00109422630.018
nucleoside phosphate biosynthetic processGO:19012931090.018
tripartite regional subdivisionGO:000735120.018
organic acid biosynthetic processGO:0016053970.018
positive regulation of programmed cell deathGO:00430682490.018
rhythmic behaviorGO:000762220.018
Rat
organ formationGO:004864530.018
negative regulation of cellular amino acid metabolic processGO:004576320.017
cellular protein catabolic processGO:00442572610.017
sulfur compound metabolic processGO:00067901010.017
negative regulation of protein modification processGO:00314002000.017
protein modification by small protein conjugationGO:00324463420.017
purine ribonucleoside monophosphate metabolic processGO:00091671860.017
spermatid differentiationGO:004851540.017
positive regulation of apoptotic processGO:00430652460.017
neurological system processGO:00508771630.017
positive regulation of cell proliferationGO:00082843010.017
protein targetingGO:00066051870.017
associative learningGO:000830610.017
positive regulation of gtp catabolic processGO:00331261660.017
negative regulation of intracellular signal transductionGO:19025321830.017
calcium ion homeostasisGO:00550741220.017
reactive nitrogen species metabolic processGO:200105730.017
positive regulation of organelle organizationGO:00106381950.017
nucleotide biosynthetic processGO:00091651090.017
spermatid developmentGO:000728640.017
matingGO:000761810.017
positive regulation of immune system processGO:00026842830.017
regulation of protein transportGO:00512232130.016
protein localization to membraneGO:00726571600.016
compound eye developmentGO:004874910.016
protein oligomerizationGO:00512591730.016
regulation of ras protein signal transductionGO:00465781550.016
regulation of cell developmentGO:00602841610.016
actin cytoskeleton organizationGO:00300362070.016
enzyme linked receptor protein signaling pathwayGO:00071673030.016
rab protein signal transductionGO:003248240.016
negative regulation of cell proliferationGO:00082852280.016
positive regulation of cell differentiationGO:00455972110.016
reactive oxygen species metabolic processGO:0072593750.016
cell fate determinationGO:000170930.016
posttranscriptional regulation of gene expressionGO:00106082130.016
photoreceptor cell differentiationGO:004653020.016
alcohol metabolic processGO:00060661140.016
cytokine productionGO:00018162470.016
regulation of mapk cascadeGO:00434082620.016
ribonucleoside monophosphate metabolic processGO:00091611870.016
epithelium developmentGO:00604292270.016
anatomical structure formation involved in morphogenesisGO:00486462840.016
regulation of immune responseGO:00507762010.016
purine nucleoside monophosphate metabolic processGO:00091261860.016
circadian behaviorGO:004851220.016
Rat
growthGO:00400072020.016
response to axon injuryGO:004867810.016
negative regulation of phosphorylationGO:00423261740.016
regulation of intracellular transportGO:00323861950.016
response to lipidGO:00339932060.016
Rat
cofactor metabolic processGO:0051186870.015
chromatin organizationGO:00063253510.015
regulation of reactive oxygen species biosynthetic processGO:190342630.015
atp metabolic processGO:00460341760.015
regulation of cytokine productionGO:00018172320.015
actin mediated cell contractionGO:0070252120.015
positive regulation of kinase activityGO:00336742040.015
regulation of small gtpase mediated signal transductionGO:00510561560.015
response to fungusGO:000962040.015
nucleoside monophosphate metabolic processGO:00091231910.015
motor neuron axon guidanceGO:000804520.015
proteolysis involved in cellular protein catabolic processGO:00516032440.015
cell growthGO:00160491600.015
regulation of vesicle mediated transportGO:00606271300.015
cellular divalent inorganic cation homeostasisGO:00725031280.015
glycoprotein metabolic processGO:00091001100.015
inner ear morphogenesisGO:004247240.015
regulation of cell adhesionGO:00301551660.015
sensory perception of painGO:001923340.015
positive regulation of transferase activityGO:00513472270.015
positive regulation of gtpase activityGO:00435471660.015
small molecule catabolic processGO:0044282920.015
neurotransmitter secretionGO:000726940.015
microtubule based processGO:00070172100.015
regulation of ion transportGO:00432691890.015
divalent inorganic cation transportGO:00725111580.015
regulation of sequence specific dna binding transcription factor activityGO:00510902110.015
single organism cell adhesionGO:00986021790.015
coenzyme metabolic processGO:0006732650.015
divalent inorganic cation homeostasisGO:00725071360.015
cardiovascular system developmentGO:00723582620.015
regulation of peptidase activityGO:00525471800.015
regulation of neural precursor cell proliferationGO:200017740.015
nerve developmentGO:002167540.015
neuroblast proliferationGO:000740540.015
positive regulation of cellular component biogenesisGO:00440891580.014
monovalent inorganic cation transportGO:00156721280.014
regulation of endopeptidase activityGO:00525481700.014
divalent metal ion transportGO:00708381520.014
metencephalon developmentGO:002203720.014
negative regulation of developmental processGO:00510932470.014
positive regulation of secretionGO:00510471160.014
response to radiationGO:00093141510.014
rna processingGO:00063962550.014
sequestering of metal ionGO:0051238240.014
cellular calcium ion homeostasisGO:00068741170.014
actin filament based movementGO:0030048170.014
mitochondrion organizationGO:00070051560.014
histone modificationGO:00165702510.014
spinal cord developmentGO:002151040.014
Rat
sequestering of calcium ionGO:0051208170.014
neurogenesisGO:00220081690.014
microtubule cytoskeleton organizationGO:00002261760.014
regulation of hormone levelsGO:00108171250.014
Rat
morphogenesis of a polarized epitheliumGO:000173830.014
cell projection assemblyGO:00300311260.014
regulation of cell morphogenesisGO:00226041530.014
cell divisionGO:00513011680.014
establishment of protein localization to organelleGO:00725941720.014
modification dependent macromolecule catabolic processGO:00436322120.014
organelle assemblyGO:00709251760.014
regulation of multi organism processGO:00439001570.014
response to woundingGO:00096111680.014
generation of neuronsGO:00486991520.014
regulation of ras gtpase activityGO:00323181280.014
regulation of protein serine threonine kinase activityGO:00719001790.014
alpha amino acid metabolic processGO:1901605720.014
covalent chromatin modificationGO:00165692540.014
fatty acid metabolic processGO:00066311150.013
purine nucleotide biosynthetic processGO:0006164840.013
regulation of protein catabolic processGO:00421761550.013
response to organic cyclic compoundGO:00140702040.013
Rat
regulation of reactive oxygen species metabolic processGO:2000377410.013
visual behaviorGO:000763220.013
regulation of protein maturationGO:19033171500.013
regulation of cell growthGO:00015581350.013
regulation of growthGO:00400081650.013
purine containing compound biosynthetic processGO:0072522880.013
limbic system developmentGO:002176130.013
Rat
chromatin modificationGO:00165682980.013
proteasomal protein catabolic processGO:00104981760.013
regulation of apoptotic signaling pathwayGO:20012331750.013
response to nitrogen compoundGO:19016981840.013
Rat
positive regulation of secretion by cellGO:19035321080.013
epithelial cell differentiationGO:00308551410.013
positive regulation of reactive oxygen species biosynthetic processGO:190342820.013
positive regulation of protein kinase activityGO:00458601900.013
regulation of actin filament based processGO:00329701410.013
positive regulation of ras gtpase activityGO:00323201170.013
cell part morphogenesisGO:00329901370.013
release of cytoplasmic sequestered nf kappabGO:000858840.013
g protein coupled receptor signaling pathwayGO:00071862070.013
negative regulation of protein phosphorylationGO:00019331400.013
negative regulation of cell cycleGO:00457861930.013
negative regulation of transferase activityGO:00513481240.013
syncytium formation by plasma membrane fusionGO:000076820.013
regulation of protein processingGO:00706131500.013
endosomal transportGO:00161971290.013
cell activationGO:00017752130.013
negative regulation of transportGO:00510511760.013
interspecies interaction between organismsGO:00444191560.013
single organismal cell cell adhesionGO:00163371480.013
symbiosis encompassing mutualism through parasitismGO:00444031560.013
establishment or maintenance of bipolar cell polarityGO:006124520.013
establishment of protein localization to membraneGO:00901501210.013
response to hormoneGO:00097251750.013
Rat
response to salt stressGO:000965130.013
response to growth factorGO:00708482050.013
Rat
primary neural tube formationGO:001402030.013
visual learningGO:000854210.013
establishment of planar polarityGO:000173630.013
purine ribonucleotide biosynthetic processGO:0009152790.013
neural tube formationGO:000184130.013
endocytosisGO:00068971590.013
regulation of protein complex assemblyGO:00432541470.013
tube closureGO:006060630.013
negative regulation of organelle organizationGO:00106391260.013
calcium ion transportGO:00068161470.013
multi organism cellular processGO:00447641560.013
cellular modified amino acid metabolic processGO:0006575640.013
cell cycle phase transitionGO:00447701730.012
regulation of neurotransmitter secretionGO:004692830.012
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.012
ubiquitin dependent protein catabolic processGO:00065112060.012
organic anion transportGO:00157111030.012
negative regulation of protein processingGO:00109551420.012
positive regulation of cell migrationGO:00303351720.012
cdc42 protein signal transductionGO:003248840.012
ribose phosphate biosynthetic processGO:0046390820.012
ribonucleotide biosynthetic processGO:0009260810.012
peptidyl tyrosine modificationGO:00182121700.012
regulation of cytoplasmic transportGO:19036491490.012
regulation of defense responseGO:00313471540.012
neuron projection regenerationGO:003110210.012
nucleocytoplasmic transportGO:00069131760.012
regulation of transmembrane transportGO:00347621390.012
tissue regenerationGO:004224630.012
cellular response to growth factor stimulusGO:00713631970.012
Rat
nuclear transportGO:00511691790.012
circulatory system developmentGO:00723592620.012
sensory perception of smellGO:000760820.012
negative regulation of proteolysisGO:00458611320.012
cerebellum developmentGO:002154920.012
wnt signaling pathwayGO:00160551560.012
salivary gland morphogenesisGO:000743540.012
axon regenerationGO:003110310.012
rna interferenceGO:001624640.012
positive regulation of cellular component movementGO:00512721810.012
positive regulation of cell motilityGO:20001471770.012
intrinsic apoptotic signaling pathwayGO:00971931270.012
protein homooligomerizationGO:00512601000.012
muscle system processGO:0003012810.012
plasma membrane organizationGO:00070091150.012
muscle contractionGO:0006936730.012
epidermis morphogenesisGO:004873030.012
glycerolipid metabolic processGO:00464861070.012
cell projection morphogenesisGO:00488581290.012
hemopoiesisGO:00300971800.012
striated muscle contractionGO:0006941520.012
dna repairGO:00062811980.012
phototransductionGO:000760230.012
modification dependent protein catabolic processGO:00199412090.012
nucleoside monophosphate catabolic processGO:00091251590.012
immune system developmentGO:00025201950.012
negative regulation of protein maturationGO:19033181420.012
regulation of mitotic cell cycleGO:00073461890.012
response to inorganic substanceGO:00100351270.012
cardiac muscle contractionGO:0060048340.012
myoblast fusionGO:000752010.012
establishment or maintenance of apical basal cell polarityGO:003508820.012
positive regulation of locomotionGO:00400171860.012
phospholipid metabolic processGO:0006644990.012
blood vessel developmentGO:00015681720.012
exocytosisGO:0006887710.011
establishment of tissue polarityGO:000716430.011
central nervous system developmentGO:00074171230.011
Rat
engulfment of apoptotic cellGO:004365220.011
glycoprotein biosynthetic processGO:0009101910.011
regulation of i kappab kinase nf kappab signalingGO:00431221620.011
viral processGO:00160321460.011
response to cytokineGO:00340972320.011
positive regulation of protein transportGO:00512221350.011
neuron differentiationGO:00301821380.011
defense response to fungusGO:005083240.011
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.011
regulation of homeostatic processGO:00328441210.011
response to bacteriumGO:00096171440.011
startle responseGO:000196430.011
positive regulation of mapk cascadeGO:00434101900.011
neural tube closureGO:000184330.011
positive regulation of proteolysisGO:00458621420.011
response to organonitrogen compoundGO:00102431560.011
Rat
angiogenesisGO:00015251470.011
mitotic cell cycle phase transitionGO:00447721620.011
chemotaxisGO:00069351570.011
taxisGO:00423301570.011
sex determinationGO:000753030.011
cell substrate adhesionGO:00315891320.011
glial cell migrationGO:000834740.011
developmental programmed cell deathGO:001062330.011
cytokinesisGO:0000910960.011
i kappab kinase nf kappab signalingGO:00072491660.011
peptidyl tyrosine phosphorylationGO:00181081700.011
atp catabolic processGO:00062001570.011
regulation of cysteine type endopeptidase activityGO:20001161270.011
monocarboxylic acid biosynthetic processGO:0072330670.011
actin filament organizationGO:00070151280.011
long term memoryGO:000761620.011
cellular response to external stimulusGO:00714961110.011
Rat
melanin metabolic processGO:000658210.011
organic acid catabolic processGO:0016054710.011
stem cell divisionGO:001714520.011
regulation of dna metabolic processGO:00510521530.011
calcium ion transmembrane transportGO:0070588760.011
thymus developmentGO:004853830.011
purine nucleoside monophosphate catabolic processGO:00091281580.011
specification of organ identityGO:001009230.011
positive regulation of cytokine productionGO:00018191670.011
cellular response to cytokine stimulusGO:00713451810.011
negative regulation of cell differentiationGO:00455961710.011
t cell differentiation in thymusGO:003307740.011
hematopoietic or lymphoid organ developmentGO:00485341860.011
neuron fate commitmentGO:004866320.011
negative regulation of synaptic transmissionGO:005080520.011
cell morphogenesis involved in differentiationGO:00009041440.011

SRD5A1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.054
inherited metabolic disorderDOID:6552420.044
musculoskeletal system diseaseDOID:172230.027
nervous system diseaseDOID:8634310.025
central nervous system diseaseDOID:3311860.025
sensory system diseaseDOID:00501552030.024
disease of cellular proliferationDOID:145661740.020
cancerDOID:1621670.020
organ system cancerDOID:00506861640.020
eye and adnexa diseaseDOID:14921500.018
eye diseaseDOID:56141490.018
amino acid metabolic disorderDOID:9252500.016
connective tissue diseaseDOID:651090.015
muscle tissue diseaseDOID:661130.015
muscular diseaseDOID:00800001140.015
immune system diseaseDOID:29141550.015
cardiovascular system diseaseDOID:12871060.015
retinal diseaseDOID:56791180.014
myopathyDOID:4231040.014
neurodegenerative diseaseDOID:12891020.013
bone diseaseDOID:0080001880.013
brain diseaseDOID:936730.012
retinal degenerationDOID:8466890.011