Homo sapiens

179 known processes

HMGB1

high mobility group box 1

(Aliases: DKFZp686A04236,HMG1,SBP-1,HMG3)

HMGB1 biological process predictions


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Biological processGO term IDProcess sizeProbabilityFunc Analog Org
negative regulation of transcription initiation from rna polymerase ii promoterGO:006063331.000
dna ligation involved in dna repairGO:005110340.877
positive regulation of cell deathGO:00109422630.809
base excision repair dna ligationGO:000628820.761
protein dna complex subunit organizationGO:0071824800.680
positive regulation of proteolysisGO:00458621420.652
positive regulation of apoptotic processGO:00430652460.590
chromatin assembly or disassemblyGO:0006333780.570
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280690.563
negative regulation of rna polymerase ii transcriptional preinitiation complex assemblyGO:001705520.556
regulation of megakaryocyte differentiationGO:0045652220.506
Human
nucleosome assemblyGO:0006334500.442
response to organic cyclic compoundGO:00140702040.342
nucleosome organizationGO:0034728660.336
dna templated transcription initiationGO:0006352350.335
regenerationGO:003109940.307
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.286
dna repairGO:00062811980.276
spermatid developmentGO:000728640.270
cellular macromolecular complex assemblyGO:00346223240.238
dna packagingGO:0006323770.215
inflammatory responseGO:0006954790.210
response to other organismGO:00517072610.209
Human
positive regulation of epithelial cell proliferationGO:0050679650.208
Human
regulation of apoptotic signaling pathwayGO:20012331750.208
positive regulation of hydrolase activityGO:00513453310.189
regulation of cysteine type endopeptidase activityGO:20001161270.183
spermatid differentiationGO:004851540.175
positive regulation of programmed cell deathGO:00430682490.171
positive regulation of endopeptidase activityGO:0010950840.169
cellular response to dna damage stimulusGO:00069743790.156
negative regulation of apoptotic processGO:00430663160.150
rna processingGO:00063962550.145
regulation of cellular response to stressGO:00801352440.144
small gtpase mediated signal transductionGO:0007264780.144
oogenesisGO:004847720.144
regulation of cell differentiationGO:00455953930.143
Human
regulation of proteolysisGO:00301622930.139
response to external biotic stimulusGO:00432072610.135
Human
rna interferenceGO:001624640.128
chromatin organizationGO:00063253510.124
apoptotic signaling pathwayGO:00971902680.123
female gamete generationGO:000729220.123
regulation of endopeptidase activityGO:00525481700.122
nucleus organizationGO:0006997280.113
chromatin modificationGO:00165682980.109
nuclear exportGO:0051168690.109
single organism cellular localizationGO:19025803320.109
post embryonic developmentGO:000979120.105
regulation of myeloid cell differentiationGO:0045637810.104
Human
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.099
response to abiotic stimulusGO:00096283360.097
rna polymerase ii transcriptional preinitiation complex assemblyGO:005112340.096
chromatin assemblyGO:0031497610.093
regulation of intracellular protein transportGO:00331571230.093
regulation of hematopoietic progenitor cell differentiationGO:1901532240.091
Human
regulation of response to dna damage stimulusGO:2001020940.090
positive regulation of transportGO:00510503360.087
immune system developmentGO:00025201950.085
negative regulation of programmed cell deathGO:00430693210.083
positive regulation of dna metabolic processGO:0051054730.083
protein maturationGO:00516042330.079
inflammatory response to antigenic stimulusGO:000243740.079
cellular protein catabolic processGO:00442572610.078
atp dependent chromatin remodelingGO:0043044250.078
v d j recombinationGO:003315130.077
posttranscriptional regulation of gene expressionGO:00106082130.077
cellular response to oxygen containing compoundGO:19017012760.073
Human
regulation of dna metabolic processGO:00510521530.072
positive regulation of cytoplasmic transportGO:1903651820.072
protein localization to organelleGO:00333652800.072
taxisGO:00423301570.071
Human
positive regulation of immune system processGO:00026842830.071
Human
determination of adult lifespanGO:000834020.068
response to lipidGO:00339932060.067
Human
regulation of cell cycleGO:00517263930.066
positive regulation of hematopoietic progenitor cell differentiationGO:190153450.065
Human
positive regulation of cellular component organizationGO:00511303760.065
regulation of intracellular transportGO:00323861950.064
base excision repairGO:0006284210.064
interspecies interaction between organismsGO:00444191560.064
cytoplasmic transportGO:00164823790.062
hematopoietic or lymphoid organ developmentGO:00485341860.062
Human
positive regulation of cysteine type endopeptidase activityGO:2001056790.059
negative regulation of catalytic activityGO:00430863350.058
chromosome segregationGO:00070591140.058
oocyte differentiationGO:000999420.058
ras protein signal transductionGO:0007265730.057
regulation of rna polymerase ii transcriptional preinitiation complex assemblyGO:004589830.057
protein dna complex assemblyGO:0065004640.056
regulation of cell cycle processGO:00105642660.056
positive regulation of homeostatic processGO:0032846470.056
Human
positive regulation of peptidase activityGO:0010952880.055
reproductive processGO:00224141060.055
oocyte developmentGO:004859910.055
regulation of nucleocytoplasmic transportGO:0046822980.055
regulation of protein export from nucleusGO:0046825150.055
viral processGO:00160321460.055
histone serine phosphorylationGO:003540440.054
positive regulation of cellular catabolic processGO:00313312840.053
regulation of cellular component biogenesisGO:00440872810.053
regulation of intrinsic apoptotic signaling pathwayGO:2001242720.053
negative regulation of apoptotic signaling pathwayGO:2001234970.053
cellular amino acid metabolic processGO:00065201160.052
cellular response to hormone stimulusGO:00328701250.051
hematopoietic progenitor cell differentiationGO:0002244380.050
Human
cell cycle phase transitionGO:00447701730.050
regulation of establishment of protein localizationGO:00702012420.049
cell death in response to oxidative stressGO:0036473290.049
mitotic nuclear divisionGO:00070671190.048
dna conformation changeGO:00711031130.048
single organism reproductive processGO:0044702980.047
regulation of protein transportGO:00512232130.046
histone modificationGO:00165702510.046
dna recombinationGO:0006310770.046
negative regulation of developmental processGO:00510932470.045
response to bacteriumGO:00096171440.045
Human
nervous system developmentGO:00073992930.045
symbiosis encompassing mutualism through parasitismGO:00444031560.044
nuclear transportGO:00511691790.044
development of primary sexual characteristicsGO:0045137350.043
cell cycle checkpointGO:00000751170.043
regulation of mitotic cell cycleGO:00073461890.042
reproductive system developmentGO:0061458560.042
modification dependent macromolecule catabolic processGO:00436322120.042
positive regulation of protein export from nucleusGO:004682760.042
histone exchangeGO:004348630.042
meiosis iGO:000712740.042
positive regulation of protein transportGO:00512221350.042
negative regulation of chromosome organizationGO:2001251480.041
proteasomal protein catabolic processGO:00104981760.041
amine metabolic processGO:0009308440.041
reproductive structure developmentGO:0048608550.041
growthGO:00400072020.041
developmental process involved in reproductionGO:0003006660.040
negative regulation of extrinsic apoptotic signaling pathwayGO:2001237520.040
negative regulation of dna templated transcription initiationGO:200014330.040
hemopoiesisGO:00300971800.040
Human
gene silencing by rnaGO:0031047260.040
regulation of cell growthGO:00015581350.040
regulation of dna bindingGO:0051101370.039
positive regulation of myeloid cell differentiationGO:0045639390.039
Human
regulation of nuclease activityGO:0032069110.038
Human
mitotic cell cycle processGO:19030472860.038
regulation of cellular amine metabolic processGO:0033238110.038
positive regulation of mitotic cell cycleGO:0045931600.037
anterior posterior axis specificationGO:000994820.037
regulation of peptidase activityGO:00525471800.037
negative regulation of cell deathGO:00605483450.037
negative regulation of cellular protein metabolic processGO:00322693530.037
autophagyGO:0006914880.037
regulation of protein complex assemblyGO:00432541470.036
gene silencingGO:0016458490.036
positive regulation of intracellular transportGO:00323881040.036
regulation of multi organism processGO:00439001570.036
protein processingGO:00164852260.035
response to cytokineGO:00340972320.035
response to steroid hormoneGO:0048545800.035
regulation of protein stabilityGO:0031647870.035
covalent chromatin modificationGO:00165692540.035
meiotic chromosome segregationGO:004513240.034
gonad developmentGO:0008406340.034
regulation of endothelial cell proliferationGO:0001936560.033
Human
regulation of mitotic metaphase anaphase transitionGO:0030071260.033
segmentationGO:003528240.033
negative regulation of cell differentiationGO:00455961710.033
regulation of cellular ketone metabolic processGO:0010565500.032
mitotic cell cycle checkpointGO:0007093680.031
cellular response to cytokine stimulusGO:00713451810.031
positive regulation of dna bindingGO:0043388170.031
regulation of erythrocyte differentiationGO:0045646170.030
Human
positive regulation of cell proliferationGO:00082843010.030
Human
response to fungusGO:000962040.030
regulation of epithelial cell proliferationGO:00506781130.030
Human
organelle fissionGO:00482851490.029
regulation of bindingGO:00510981110.029
positive regulation of cellular amino acid metabolic processGO:004576430.029
rna splicing via transesterification reactionsGO:0000375900.029
negative regulation of phosphate metabolic processGO:00459362670.029
system processGO:00030083490.028
neuromuscular junction developmentGO:000752830.028
immune responseGO:00069553070.028
viral life cycleGO:00190581320.028
protein acylationGO:00435431380.028
regulation of interleukin 1 mediated signaling pathwayGO:200065930.028
negative regulation of cell cycle processGO:00109481210.027
cell developmentGO:00484683280.027
regulation of cellular amino acid metabolic processGO:000652160.027
negative regulation of multi organism processGO:0043901920.027
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434710.026
negative regulation of cellular component organizationGO:00511292350.026
positive regulation of cell cycleGO:00457871400.026
multicellular organismal agingGO:001025930.026
neurogenesisGO:00220081690.026
positive regulation of developmental processGO:00510943140.026
Human
regulation of homeostatic processGO:00328441210.025
Human
cellular response to organic cyclic compoundGO:00714071270.025
endothelial cell proliferationGO:0001935650.024
Human
positive regulation of endothelial cell proliferationGO:0001938370.024
Human
dna replicationGO:00062601160.024
cellular component morphogenesisGO:00329893140.024
negative regulation of cell cycleGO:00457861930.024
erythrocyte homeostasisGO:0034101310.024
Human
cell junction organizationGO:0034330790.024
regulation of proteasomal protein catabolic processGO:0061136870.024
response to oxygen containing compoundGO:19017003690.023
Human
positive regulation of cellular amine metabolic processGO:003324070.023
ribonucleoside triphosphate catabolic processGO:00092033910.023
negative regulation of catabolic processGO:00098951040.022
reproductionGO:0000003630.022
organelle assemblyGO:00709251760.022
positive regulation of catabolic processGO:00098963100.022
negative regulation of protein metabolic processGO:00512483910.022
cellular macromolecule catabolic processGO:00442653800.022
multi organism cellular processGO:00447641560.022
regulation of protein catabolic processGO:00421761550.021
posttranscriptional gene silencingGO:0016441250.021
positive regulation of meiotic cell cycleGO:005144620.021
regulation of meiotic cell cycleGO:005144540.021
g1 s transition of mitotic cell cycleGO:0000082780.020
rna splicingGO:00083801310.020
double strand break repairGO:00063021010.020
intracellular protein transportGO:00068862700.020
negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:1902042150.020
regulation of cytoplasmic transportGO:19036491490.020
cellular response to growth factor stimulusGO:00713631970.019
somatic diversification of immune receptorsGO:000220080.019
regulation of response to external stimulusGO:00321012220.019
cell growthGO:00160491600.019
response to oxidative stressGO:00069791210.019
regulation of mitosisGO:0007088630.019
activation of cysteine type endopeptidase activity involved in apoptotic processGO:0006919490.019
nuclear divisionGO:00002801280.019
negative regulation of growthGO:0045926970.019
vesicle mediated transportGO:00161923710.019
negative regulation of intracellular signal transductionGO:19025321830.018
positive regulation of bindingGO:0051099450.018
mitotic cell cycleGO:00002783260.018
dna ligationGO:0006266100.018
response to radiationGO:00093141510.018
circulatory system developmentGO:00723592620.018
negative regulation of mitotic cell cycle phase transitionGO:1901991850.018
negative regulation of protein processingGO:00109551420.018
regulation of small gtpase mediated signal transductionGO:00510561560.017
negative regulation of protein complex assemblyGO:0031333430.017
regulation of protein processingGO:00706131500.017
regulation of extrinsic apoptotic signaling pathwayGO:2001236850.017
chemotaxisGO:00069351570.017
Human
regulation of protein localizationGO:00328802960.017
regulation of dna templated transcription initiationGO:200014290.017
positive regulation of cell differentiationGO:00455972110.016
Human
signal transduction by phosphorylationGO:00230142970.016
axon cargo transportGO:000808820.016
defense responseGO:00069523150.016
regulation of cellular protein catabolic processGO:1903362960.016
multicellular organismal reproductive processGO:0048609400.016
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.016
activation of cysteine type endopeptidase activityGO:0097202570.016
regulation of nuclear divisionGO:0051783650.015
regulation of chromosome organizationGO:00330441030.015
protein acetylationGO:00064731160.015
cellular response to oxidative stressGO:0034599850.015
regulation of proteolysis involved in cellular protein catabolic processGO:1903050910.015
modification dependent protein catabolic processGO:00199412090.015
negative regulation of proteolysisGO:00458611320.015
regulation of chromatin assemblyGO:001084720.015
cell chemotaxisGO:00603261120.015
Human
mitotic cell cycle phase transitionGO:00447721620.015
neurological system processGO:00508771630.015
embryo developmentGO:00097901230.015
positive regulation of cell cycle processGO:00900681060.015
cellular ketone metabolic processGO:0042180800.015
multicellular organism reproductionGO:0032504420.015
sensory perceptionGO:00076001030.015
positive regulation of intracellular protein transportGO:0090316760.015
cytokine mediated signaling pathwayGO:00192211090.015
regulation of phosphatase activityGO:0010921810.015
proteolysis involved in cellular protein catabolic processGO:00516032440.015
regulation of symbiosis encompassing mutualism through parasitismGO:00439031090.014
negative regulation of phosphorus metabolic processGO:00105632670.014
positive regulation of nucleocytoplasmic transportGO:0046824540.014
locomotory behaviorGO:000762610.014
maintenance of locationGO:00512351120.014
protein deubiquitinationGO:0016579790.014
rna splicing via transesterification reactions with bulged adenosine as nucleophileGO:0000377890.014
protein catabolic processGO:00301633250.014
response to hormoneGO:00097251750.014
protein export from nucleusGO:0006611290.013
negative regulation of mitotic anaphase promoting complex activityGO:006056440.013
endocytosisGO:00068971590.013
negative regulation of intrinsic apoptotic signaling pathwayGO:2001243400.013
regulation of immune responseGO:00507762010.013
tripartite regional subdivisionGO:000735120.013
cellular response to endogenous stimulusGO:00714953360.013
generation of neuronsGO:00486991520.013
protein stabilizationGO:0050821640.013
cell morphogenesisGO:00009022960.013
sex differentiationGO:0007548450.013
purine nucleoside catabolic processGO:00061523980.013
cell cycle g1 s phase transitionGO:0044843800.012
protein modification by small protein removalGO:0070646920.012
positive chemotaxisGO:0050918330.012
Human
regulation of wnt signaling pathwayGO:00301111230.012
regulation of ras protein signal transductionGO:00465781550.012
negative regulation of organelle organizationGO:00106391260.012
nucleocytoplasmic transportGO:00069131760.012
nucleic acid phosphodiester bond hydrolysisGO:00903051020.012
Human
protein complex disassemblyGO:0043241520.012
purine nucleoside triphosphate catabolic processGO:00091463920.012
metaphase anaphase transition of cell cycleGO:0044784210.012
positive regulation of cellular component biogenesisGO:00440891580.012
enzyme linked receptor protein signaling pathwayGO:00071673030.012
gamete generationGO:0007276250.012
cell substrate junction assemblyGO:0007044350.012
cellular amine metabolic processGO:0044106410.012
sexual reproductionGO:0019953370.012
regulation of meiosisGO:004002030.012
posttranscriptional gene silencing by rnaGO:0035194250.012
methylationGO:00322591060.012
regulation of dephosphorylationGO:0035303960.011
response to oxygen levelsGO:00704821000.011
erythrocyte differentiationGO:0030218280.011
Human
peptidyl lysine modificationGO:00182051440.011
cellular response to biotic stimulusGO:0071216710.011
Human
regulation of transcription initiation from rna polymerase ii promoterGO:006026080.011
macromolecular complex disassemblyGO:0032984600.011
nucleosome positioningGO:001658430.011
response to woundingGO:00096111680.011
regulation of mitotic cell cycle phase transitionGO:19019901180.011
nuclear importGO:00511701060.011
negative regulation of mitotic cell cycleGO:00459301020.011
positive regulation of chromatin assembly or disassemblyGO:004579920.011
ribonucleoside catabolic processGO:00424544060.011
negative regulation of cellular catabolic processGO:0031330830.011
negative regulation of cell cycle phase transitionGO:1901988890.011
secretion by cellGO:00329402260.011
regulation of cytoskeleton organizationGO:00514931770.011
stem cell developmentGO:0048864690.010
negative regulation of hydrolase activityGO:00513461820.010
regulation of oocyte developmentGO:006028110.010
asymmetric neuroblast divisionGO:005505910.010
regulation of protein import into nucleusGO:0042306780.010
response to alcoholGO:0097305640.010

HMGB1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:145661740.012
disease of mental healthDOID:150700.012