Homo sapiens

131 known processes

MSH2

mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)

(Aliases: HNPCC,COCA1,HNPCC1,FCC1,LCFS2)

MSH2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
double strand break repairGO:00063021011.000
Mouse
cellular response to dna damage stimulusGO:00069743791.000
dna repairGO:00062811981.000
mismatch repairGO:0006298151.000
nucleotide excision repairGO:0006289310.998
dna catabolic processGO:0006308490.998
Yeast
somatic diversification of immune receptors via somatic mutationGO:000256610.997
Mouse
dna recombinationGO:0006310770.997
meiosis iGO:000712740.995
Yeast
regulation of dna metabolic processGO:00510521530.985
double strand break repair via homologous recombinationGO:0000724500.984
purine nucleoside catabolic processGO:00061523980.975
nucleic acid phosphodiester bond hydrolysisGO:00903051020.974
Yeast
purine nucleotide catabolic processGO:00061954050.964
dna double strand break processingGO:0000729100.957
telomere organizationGO:0032200330.956
negative regulation of dna metabolic processGO:0051053570.950
purine nucleoside triphosphate catabolic processGO:00091463920.947
anatomical structure homeostasisGO:00602491000.923
nucleoside triphosphate catabolic processGO:00091433940.923
recombinational repairGO:0000725500.900
cellular macromolecule catabolic processGO:00442653800.896
Yeast
response to uvGO:0009411730.895
Mouse
meiotic nuclear divisionGO:0007126100.883
Yeast
positive regulation of helicase activityGO:005109660.881
ribonucleotide catabolic processGO:00092614050.866
double strand break repair via single strand annealingGO:004500240.848
somatic recombination of immunoglobulin gene segmentsGO:001644740.848
Mouse
nucleoside monophosphate catabolic processGO:00091251590.839
dna catabolic process endonucleolyticGO:0000737370.820
Yeast
nervous system developmentGO:00073992930.806
purine ribonucleoside catabolic processGO:00461303980.804
purine containing compound catabolic processGO:00725234110.795
purine ribonucleotide catabolic processGO:00091544040.790
interstrand cross link repairGO:003629730.781
Yeast Fly
somatic recombination of immunoglobulin genes involved in immune responseGO:000220430.780
Mouse
regulation of meiotic cell cycleGO:005144540.763
regulation of helicase activityGO:005109580.756
ribonucleoside catabolic processGO:00424544060.721
ribonucleoside monophosphate catabolic processGO:00091581580.718
telomere maintenanceGO:0000723320.703
isotype switchingGO:004519030.652
Mouse
somatic diversification of immunoglobulins involved in immune responseGO:000220830.642
Mouse
dna dependent dna replicationGO:0006261440.628
somatic hypermutation of immunoglobulin genesGO:001644610.625
Mouse
nuclear divisionGO:00002801280.584
Yeast
purine ribonucleoside monophosphate catabolic processGO:00091691580.580
meiotic cell cycle processGO:190304680.540
Yeast
nucleoside catabolic processGO:00091644080.531
organelle fissionGO:00482851490.530
Yeast
glycosyl compound catabolic processGO:19016584130.519
purine ribonucleoside metabolic processGO:00461284370.469
mrna metabolic processGO:00160711750.454
nucleoside phosphate catabolic processGO:19012924120.451
dna integrity checkpointGO:0031570710.438
Mouse
nucleoside monophosphate metabolic processGO:00091231910.438
meiotic cell cycleGO:0051321130.429
Yeast
regulation of dna recombinationGO:0000018230.424
sex determinationGO:000753030.408
Yeast
atp catabolic processGO:00062001570.390
negative regulation of dna recombinationGO:004591060.388
post embryonic developmentGO:000979120.358
purine ribonucleoside triphosphate metabolic processGO:00092054110.350
somatic diversification of immunoglobulinsGO:001644560.345
Mouse
regulation of meiosisGO:004002030.324
cell developmentGO:00484683280.301
Mouse
response to light stimulusGO:0009416870.297
Mouse
regulation of dna replicationGO:0006275680.290
intrinsic apoptotic signaling pathwayGO:00971931270.270
Mouse Worm
dna damage checkpointGO:0000077680.254
Mouse
positive regulation of hydrolase activityGO:00513453310.247
dna replicationGO:00062601160.247
organophosphate catabolic processGO:00464344300.240
reciprocal meiotic recombinationGO:000713140.236
reproductionGO:0000003630.235
Yeast Mouse Worm
meiotic chromosome segregationGO:004513240.234
rna dependent dna replicationGO:0006278160.227
nucleoside triphosphate metabolic processGO:00091414220.227
dna conformation changeGO:00711031130.226
somatic cell dna recombinationGO:001644460.211
Mouse
purine nucleoside triphosphate metabolic processGO:00091444120.202
ribonucleoside triphosphate catabolic processGO:00092033910.202
telomere maintenance via telomeraseGO:000700480.200
response to radiationGO:00093141510.199
Mouse
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002460400.197
Mouse
regulation of cell cycle phase transitionGO:19019871260.195
Mouse
cellular macromolecular complex assemblyGO:00346223240.193
response to abiotic stimulusGO:00096283360.191
Mouse
reproductive system developmentGO:0061458560.186
Mouse
immune system developmentGO:00025201950.185
Mouse
purine nucleoside monophosphate catabolic processGO:00091281580.182
nucleotide catabolic processGO:00091664080.177
histone modificationGO:00165702510.171
response to caffeineGO:003100030.169
single organism reproductive processGO:0044702980.161
Yeast Mouse
gene conversionGO:003582210.154
Yeast
purine nucleoside monophosphate metabolic processGO:00091261860.147
adaptive immune responseGO:0002250490.144
Mouse
chromatin modificationGO:00165682980.143
cellular response to abiotic stimulusGO:00712141170.129
negative regulation of mitotic cell cycleGO:00459301020.128
Mouse
rna processingGO:00063962550.127
purine ribonucleoside triphosphate catabolic processGO:00092073910.117
negative regulation of mitotic cell cycle phase transitionGO:1901991850.113
Mouse
regulation of cell cycleGO:00517263930.112
Mouse
embryo development ending in birth or egg hatchingGO:0009792340.112
Mouse
blastocyst developmentGO:000182430.109
determination of adult lifespanGO:000834020.103
Mouse
regulation of double strand break repairGO:2000779220.102
covalent chromatin modificationGO:00165692540.102
translesion synthesisGO:001998580.099
microtubule based processGO:00070172100.090
mitotic recombinationGO:000631280.089
Yeast
ribonucleoside triphosphate metabolic processGO:00091994120.087
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630500.085
Mouse Worm
mitotic cell cycleGO:00002783260.082
Mouse
atp metabolic processGO:00460341760.079
cell projection organizationGO:00300302520.077
leukocyte activation involved in immune responseGO:0002366300.077
Mouse
neurogenesisGO:00220081690.074
non recombinational repairGO:0000726140.072
cell divisionGO:00513011680.070
dna strand elongation involved in dna replicationGO:000627130.068
reproductive processGO:00224141060.067
Yeast Mouse
negative regulation of cell cycleGO:00457861930.067
Mouse
cellular ketone metabolic processGO:0042180800.065
carbohydrate metabolic processGO:00059752070.065
oogenesisGO:004847720.064
production of molecular mediator of immune responseGO:0002440370.062
Mouse
mitotic cell cycle processGO:19030472860.062
Mouse
gene loopingGO:009020210.062
circulatory system developmentGO:00723592620.061
female gamete generationGO:000729220.058
b cell activation involved in immune responseGO:000231250.057
Mouse
g2 dna damage checkpointGO:0031572260.057
regulation of dna repairGO:0006282470.057
developmental process involved in reproductionGO:0003006660.054
Yeast Mouse
double strand break repair via nonhomologous end joiningGO:0006303100.053
somatic diversification of immune receptorsGO:000220080.053
Mouse
negative regulation of cell deathGO:00605483450.050
Mouse
regulation of mitotic cell cycle phase transitionGO:19019901180.048
Mouse
organophosphate biosynthetic processGO:00904071630.048
mrna processingGO:00063971330.047
cell morphogenesisGO:00009022960.047
maintenance of dna repeat elementsGO:004357040.046
internal protein amino acid acetylationGO:00064751010.045
immunoglobulin productionGO:0002377120.044
Mouse
cellular amino acid metabolic processGO:00065201160.044
cell type specific apoptotic processGO:00972851250.044
Mouse
dna strand elongationGO:002261650.044
chromosome segregationGO:00070591140.043
regulation of gene expression epigeneticGO:0040029730.043
Yeast
receptor mediated endocytosisGO:0006898840.042
rna 3 end processingGO:0031123350.041
regulation of mitotic cell cycleGO:00073461890.039
Mouse
regulation of cell cycle processGO:00105642660.039
Mouse
telomere maintenance via recombinationGO:000072240.038
cell fate commitmentGO:0045165270.037
Yeast
regenerationGO:003109940.037
immune responseGO:00069553070.036
Mouse
regulation of double strand break repair via homologous recombinationGO:0010569110.036
cell activation involved in immune responseGO:0002263300.036
Mouse
neuron developmentGO:00486661130.035
brain developmentGO:0007420970.035
negative regulation of meiotic cell cycleGO:005144720.034
apoptotic signaling pathwayGO:00971902680.034
Mouse Worm
carbohydrate derivative biosynthetic processGO:19011372070.033
mitotic dna integrity checkpointGO:0044774300.033
Mouse
lymphocyte mediated immunityGO:0002449480.033
Mouse
leukocyte activationGO:00453211640.033
Mouse
response to nitrogen compoundGO:19016981840.031
ribonucleoside monophosphate metabolic processGO:00091611870.031
regulation of cell divisionGO:00513021160.031
immunoglobulin production involved in immunoglobulin mediated immune responseGO:000238150.030
Mouse
negative regulation of cell cycle phase transitionGO:1901988890.029
Mouse
generation of neuronsGO:00486991520.029
regulation of cellular amine metabolic processGO:0033238110.029
cell activationGO:00017752130.028
Mouse
chromatin organizationGO:00063253510.027
head developmentGO:00603221080.026
leukocyte mediated immunityGO:0002443590.026
Mouse
dna catabolic process exonucleolyticGO:0000738170.026
rna splicingGO:00083801310.026
humoral immune responseGO:0006959490.026
regulation of chromosome organizationGO:00330441030.026
ribosome assemblyGO:004225590.026
dna duplex unwindingGO:0032508300.025
response to organic cyclic compoundGO:00140702040.025
cellular response to endogenous stimulusGO:00714953360.024
negative regulation of catalytic activityGO:00430863350.023
internal peptidyl lysine acetylationGO:0018393970.023
response to oxygen containing compoundGO:19017003690.022
endocytosisGO:00068971590.022
regulation of transferase activityGO:00513383550.022
embryo developmentGO:00097901230.022
Mouse
multicellular organismal agingGO:001025930.022
Mouse
lymphocyte activationGO:00466491330.022
Mouse
cenp a containing chromatin organizationGO:006164110.021
posttranscriptional regulation of gene expressionGO:00106082130.021
negative regulation of apoptotic processGO:00430663160.021
Mouse
multicellular organism reproductionGO:0032504420.020
Mouse
peptidyl lysine acetylationGO:00183941010.020
growthGO:00400072020.020
cell cycle phase transitionGO:00447701730.019
Mouse
negative regulation of organelle organizationGO:00106391260.019
dendrite developmentGO:0016358240.018
immunoglobulin mediated immune responseGO:0016064100.018
Mouse
regulation of kinase activityGO:00435493140.018
regulation of nuclear divisionGO:0051783650.018
negative regulation of developmental processGO:00510932470.017
response to inorganic substanceGO:00100351270.017
regulation of protein kinase activityGO:00458592890.017
negative regulation of transferase activityGO:00513481240.016
mrna 3 end processingGO:0031124240.016
negative regulation of phosphate metabolic processGO:00459362670.016
positive regulation of mitochondrial membrane potentialGO:001091810.016
defense responseGO:00069523150.016
immune effector processGO:00022521590.016
Mouse
positive regulation of cellular amino acid metabolic processGO:004576430.015
regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediatorGO:190216570.015
negative regulation of cell differentiationGO:00455961710.015
base excision repairGO:0006284210.015
positive regulation of mitotic cell cycle spindle assembly checkpointGO:009026760.015
peptidyl serine phosphorylationGO:00181051010.015
neuron projection developmentGO:00311751060.014
dsdna loop formationGO:009057910.014
regulation of response to dna damage stimulusGO:2001020940.014
b cell activationGO:0042113330.014
Mouse
lymphocyte activation involved in immune responseGO:0002285200.014
Mouse
negative regulation of meiosisGO:004583510.014
protein modification by small protein conjugationGO:00324463420.014
cellular response to ionizing radiationGO:0071479320.014
regulation of cytokine productionGO:00018172320.013
reciprocal dna recombinationGO:003582540.013
protein methylationGO:0006479740.013
cell projection morphogenesisGO:00488581290.013
signal transduction by phosphorylationGO:00230142970.013
g2 m transition of mitotic cell cycleGO:0000086410.012
cellular protein complex assemblyGO:00436231880.012
regulation of cellular respirationGO:004345740.012
leading strand elongationGO:000627210.012
methylationGO:00322591060.012
cellular response to organic cyclic compoundGO:00714071270.012
chromatin remodelingGO:0006338550.012
protein ubiquitinationGO:00165673140.012
negative regulation of programmed cell deathGO:00430693210.012
Mouse
positive regulation of cell deathGO:00109422630.012
protein acylationGO:00435431380.011
viral processGO:00160321460.011
protein oligomerizationGO:00512591730.011
reproductive structure developmentGO:0048608550.011
Mouse
cytokine productionGO:00018162470.011
nucleosome assemblyGO:0006334500.011
peptidyl lysine modificationGO:00182051440.011
sex differentiationGO:0007548450.010
Mouse
secretionGO:00469032540.010
response to biotic stimulusGO:00096072760.010
snrna modificationGO:004003110.010
cenp a containing nucleosome assemblyGO:003408010.010
system processGO:00030083490.010

MSH2 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:145661740.429
immune system diseaseDOID:29141550.208
hematopoietic system diseaseDOID:741000.054
cancerDOID:1621670.050
skin diseaseDOID:37330.010
integumentary system diseaseDOID:16430.010
lynch syndromeDOID:388330.005