Homo sapiens

126 known processes

MSH6

mutS homolog 6 (E. coli)

(Aliases: HNPCC5,HSAP,GTBP)

MSH6 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
mismatch repairGO:0006298151.000
cellular response to dna damage stimulusGO:00069743790.999
dna repairGO:00062811980.999
double strand break repairGO:00063021010.998
meiosis iGO:000712740.993
Yeast
dna recombinationGO:0006310770.991
nucleotide excision repairGO:0006289310.987
somatic recombination of immunoglobulin gene segmentsGO:001644740.982
Mouse
positive regulation of helicase activityGO:005109660.966
isotype switchingGO:004519030.960
Mouse
double strand break repair via homologous recombinationGO:0000724500.947
cell cycle checkpointGO:00000751170.941
dna damage checkpointGO:0000077680.930
double strand break repair via single strand annealingGO:004500240.915
dna replicationGO:00062601160.891
negative regulation of cell cycle processGO:00109481210.880
interstrand cross link repairGO:003629730.879
Yeast
maintenance of dna repeat elementsGO:004357040.878
Zebrafish Worm
g2 dna damage checkpointGO:0031572260.867
somatic diversification of immunoglobulins involved in immune responseGO:000220830.856
Mouse
negative regulation of dna recombinationGO:004591060.856
sex determinationGO:000753030.849
dna double strand break processingGO:0000729100.848
negative regulation of mitotic cell cycleGO:00459301020.830
dna conformation changeGO:00711031130.811
recombinational repairGO:0000725500.784
somatic recombination of immunoglobulin genes involved in immune responseGO:000220430.774
Mouse
negative regulation of mitotic cell cycle phase transitionGO:1901991850.757
intra s dna damage checkpointGO:003157340.735
gene conversionGO:003582210.700
nucleoside monophosphate catabolic processGO:00091251590.682
non recombinational repairGO:0000726140.668
purine ribonucleoside monophosphate metabolic processGO:00091671860.665
nucleoside monophosphate metabolic processGO:00091231910.656
negative regulation of dna metabolic processGO:0051053570.651
double strand break repair via nonhomologous end joiningGO:0006303100.640
ribonucleoside monophosphate metabolic processGO:00091611870.618
dna integrity checkpointGO:0031570710.618
response to uvGO:0009411730.612
Mouse
dna catabolic processGO:0006308490.604
regulation of dna metabolic processGO:00510521530.600
translesion synthesisGO:001998580.575
regulation of cell cycle phase transitionGO:19019871260.571
mitotic recombinationGO:000631280.563
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630500.560
Mouse
response to radiationGO:00093141510.535
Mouse
negative regulation of cell cycleGO:00457861930.532
postreplication repairGO:0006301120.527
chromosome segregationGO:00070591140.514
nucleic acid phosphodiester bond hydrolysisGO:00903051020.511
purine ribonucleoside monophosphate catabolic processGO:00091691580.507
response to abiotic stimulusGO:00096283360.501
Mouse
ribonucleoside catabolic processGO:00424544060.501
dna dependent dna replicationGO:0006261440.484
nucleoside triphosphate catabolic processGO:00091433940.478
somatic diversification of immunoglobulinsGO:001644560.475
Mouse
regulation of cell cycleGO:00517263930.475
mitotic cell cycle checkpointGO:0007093680.468
chromatin remodelingGO:0006338550.461
mitotic dna integrity checkpointGO:0044774300.458
blastocyst developmentGO:000182430.449
somatic diversification of immune receptors via somatic mutationGO:000256610.420
Mouse
regulation of dna recombinationGO:0000018230.419
mitotic cell cycle phase transitionGO:00447721620.419
immunoglobulin production involved in immunoglobulin mediated immune responseGO:000238150.409
Mouse
purine ribonucleoside metabolic processGO:00461284370.405
determination of adult lifespanGO:000834020.401
Mouse
purine nucleoside monophosphate catabolic processGO:00091281580.396
meiotic nuclear divisionGO:0007126100.390
Yeast
somatic diversification of immune receptorsGO:000220080.389
Mouse
embryo developmentGO:00097901230.376
negative regulation of cell cycle phase transitionGO:1901988890.375
anatomical structure homeostasisGO:00602491000.361
ribonucleoside monophosphate catabolic processGO:00091581580.356
telomere maintenanceGO:0000723320.353
cellular response to nitrogen compoundGO:19016991440.346
base excision repairGO:0006284210.346
female gamete generationGO:000729220.341
mitotic cell cycleGO:00002783260.337
response to organic cyclic compoundGO:00140702040.315
chromatin modificationGO:00165682980.312
purine ribonucleoside catabolic processGO:00461303980.312
dna strand elongationGO:002261650.307
purine nucleoside monophosphate metabolic processGO:00091261860.292
mitotic dna damage checkpointGO:0044773280.291
response to nitrogen compoundGO:19016981840.276
cell cycle phase transitionGO:00447701730.275
cellular response to endogenous stimulusGO:00714953360.269
cell activationGO:00017752130.262
Mouse
negative regulation of organelle organizationGO:00106391260.254
post embryonic developmentGO:000979120.252
chromatin assembly or disassemblyGO:0006333780.239
g2 m transition of mitotic cell cycleGO:0000086410.232
dna strand elongation involved in dna replicationGO:000627130.229
cellular amine metabolic processGO:0044106410.228
negative regulation of cell deathGO:00605483450.225
apoptotic signaling pathwayGO:00971902680.212
Mouse
mitotic cell cycle processGO:19030472860.209
regulation of mitotic cell cycleGO:00073461890.206
purine ribonucleoside triphosphate metabolic processGO:00092054110.205
cell developmentGO:00484683280.203
dna biosynthetic processGO:0071897400.202
regulation of meiotic cell cycleGO:005144540.202
male sex differentiationGO:0046661250.200
regenerationGO:003109940.196
chromatin organizationGO:00063253510.195
cellular response to organonitrogen compoundGO:00714171240.191
regulation of cell cycle processGO:00105642660.188
nucleosome organizationGO:0034728660.185
cellular amino acid metabolic processGO:00065201160.183
purine nucleoside triphosphate catabolic processGO:00091463920.180
meiotic chromosome segregationGO:004513240.179
intrinsic apoptotic signaling pathwayGO:00971931270.178
Mouse
cell activation involved in immune responseGO:0002263300.175
Mouse
regulation of gene expression epigeneticGO:0040029730.171
atp catabolic processGO:00062001570.171
nucleoside phosphate catabolic processGO:19012924120.168
nuclear divisionGO:00002801280.162
Yeast
cell divisionGO:00513011680.160
positive regulation of hydrolase activityGO:00513453310.158
chordate embryonic developmentGO:0043009340.152
dna catabolic process endonucleolyticGO:0000737370.146
regulation of bindingGO:00510981110.144
meiotic cell cycle processGO:190304680.141
Yeast
regulation of double strand break repairGO:2000779220.141
purine nucleotide catabolic processGO:00061954050.140
regulation of mitotic cell cycle phase transitionGO:19019901180.138
development of primary male sexual characteristicsGO:0046546230.134
response to organonitrogen compoundGO:00102431560.133
oogenesisGO:004847720.128
single organism reproductive processGO:0044702980.128
amine metabolic processGO:0009308440.125
regulation of viral genome replicationGO:0045069480.124
response to ionizing radiationGO:0010212650.124
production of molecular mediator of immune responseGO:0002440370.124
Mouse
nucleosome assemblyGO:0006334500.123
regulation of helicase activityGO:005109580.119
purine containing compound catabolic processGO:00725234110.115
mitotic dna replication checkpointGO:003331420.112
positive regulation of cellular amino acid metabolic processGO:004576430.112
positive regulation of cell deathGO:00109422630.111
meiotic gene conversionGO:000631110.109
nucleoside triphosphate metabolic processGO:00091414220.108
purine nucleoside triphosphate metabolic processGO:00091444120.108
positive regulation of programmed cell deathGO:00430682490.108
regulation of cellular amine metabolic processGO:0033238110.107
ribonucleotide catabolic processGO:00092614050.106
dna replication dependent nucleosome organizationGO:0034723320.102
leukocyte activationGO:00453211640.101
Mouse
response to caffeineGO:003100030.097
reciprocal meiotic recombinationGO:000713140.097
covalent chromatin modificationGO:00165692540.095
dna geometric changeGO:0032392320.092
meiotic cell cycleGO:0051321130.090
Yeast
mitotic g2 dna damage checkpointGO:000709570.090
embryo development ending in birth or egg hatchingGO:0009792340.090
response to hormoneGO:00097251750.090
glycosyl compound catabolic processGO:19016584130.088
cellular ketone metabolic processGO:0042180800.088
nucleotide catabolic processGO:00091664080.087
chromatin silencingGO:0006342120.087
cellular macromolecule catabolic processGO:00442653800.086
intracellular protein transportGO:00068862700.084
atp metabolic processGO:00460341760.084
nuclear transportGO:00511691790.083
cellular response to abiotic stimulusGO:00712141170.082
cell cycle arrestGO:0007050710.081
regulation of response to dna damage stimulusGO:2001020940.081
dna packagingGO:0006323770.081
generation of precursor metabolites and energyGO:0006091680.081
histone exchangeGO:004348630.078
regulation of nucleocytoplasmic transportGO:0046822980.076
cytoplasmic transportGO:00164823790.074
cell morphogenesisGO:00009022960.074
purine ribonucleotide catabolic processGO:00091544040.074
nucleoside catabolic processGO:00091644080.074
ribonucleoside triphosphate catabolic processGO:00092033910.072
muscle system processGO:0003012810.071
cellular response to hormone stimulusGO:00328701250.071
meiotic cell cycle checkpointGO:003331310.070
signal transduction by p53 class mediatorGO:0072331720.070
oxidation reduction processGO:00551143960.069
carbohydrate derivative biosynthetic processGO:19011372070.068
response to light stimulusGO:0009416870.067
Mouse
reproductionGO:0000003630.065
Yeast
nervous system developmentGO:00073992930.065
leukocyte activation involved in immune responseGO:0002366300.062
Mouse
gene silencingGO:0016458490.062
reciprocal dna recombinationGO:003582540.061
male gonad developmentGO:0008584230.060
response to oxygen containing compoundGO:19017003690.059
regulation of dna replicationGO:0006275680.059
negative regulation of meiotic cell cycleGO:005144720.059
negative regulation of programmed cell deathGO:00430693210.058
cellular response to purine containing compoundGO:007141530.057
lymphocyte activation involved in immune responseGO:0002285200.057
Mouse
hemopoiesisGO:00300971800.056
adaptive immune responseGO:0002250490.055
Mouse
telomere organizationGO:0032200330.055
lymphocyte activationGO:00466491330.055
Mouse
regulation of symbiosis encompassing mutualism through parasitismGO:00439031090.055
histone h3 k9 modificationGO:0061647110.055
response to purine containing compoundGO:0014074400.054
cellular response to oxygen containing compoundGO:19017012760.054
actin filament based processGO:00300292240.053
regulation of protein localizationGO:00328802960.053
regulation of meiosisGO:004002030.051
nucleocytoplasmic transportGO:00069131760.050
vesicle mediated transportGO:00161923710.050
ribonucleoside triphosphate metabolic processGO:00091994120.050
dna damage induced protein phosphorylationGO:000697550.049
rna interferenceGO:001624640.048
organelle fissionGO:00482851490.048
Yeast
developmental process involved in reproductionGO:0003006660.047
leukocyte mediated immunityGO:0002443590.047
Mouse
cellular component morphogenesisGO:00329893140.046
microtubule cytoskeleton organizationGO:00002261760.046
somatic hypermutation of immunoglobulin genesGO:001644610.046
Mouse
regulation of viral processGO:00507921030.045
enzyme linked receptor protein signaling pathwayGO:00071673030.045
regulation of growth rateGO:004000910.045
response to alkaloidGO:0043279200.045
protein maturationGO:00516042330.045
protein acylationGO:00435431380.045
dna replication independent nucleosome organizationGO:0034724270.044
segmentationGO:003528240.044
immunoglobulin productionGO:0002377120.042
Mouse
response to organophosphorusGO:0046683410.041
chromatin assemblyGO:0031497610.040
nuclear exportGO:0051168690.040
negative regulation of gene expression epigeneticGO:0045814190.039
regulation of growthGO:00400081650.038
immune system developmentGO:00025201950.038
Mouse
organonitrogen compound biosynthetic processGO:19015662000.038
reproductive processGO:00224141060.038
regulation of cellular response to stressGO:00801352440.038
intracellular mrna localizationGO:000829810.038
telomere maintenance via telomeraseGO:000700480.038
response to inorganic substanceGO:00100351270.037
nucleotide biosynthetic processGO:00091651090.037
mitotic g2 m transition checkpointGO:004481890.036
regulation of double strand break repair via homologous recombinationGO:0010569110.036
viral life cycleGO:00190581320.036
telomere maintenance via recombinationGO:000072240.035
b cell activationGO:0042113330.035
Mouse
somatic cell dna recombinationGO:001644460.034
Mouse
chromosome condensationGO:0030261150.034
regulation of cytoplasmic transportGO:19036491490.034
atp dependent chromatin remodelingGO:0043044250.034
microtubule based processGO:00070172100.034
negative regulation of cellular component organizationGO:00511292350.033
regulation of cellular ketone metabolic processGO:0010565500.033
multicellular organismal agingGO:001025930.033
Mouse
lymphocyte mediated immunityGO:0002449480.033
Mouse
mitotic centrosome separationGO:000710010.032
positive regulation of protein transportGO:00512221350.032
internal protein amino acid acetylationGO:00064751010.031
cell projection organizationGO:00300302520.031
organophosphate biosynthetic processGO:00904071630.031
leukocyte differentiationGO:0002521980.031
positive regulation of cellular amine metabolic processGO:003324070.030
regulation of establishment of protein localizationGO:00702012420.030
generation of neuronsGO:00486991520.030
negative regulation of apoptotic processGO:00430663160.030
organ morphogenesisGO:00098871470.030
rna localizationGO:0006403410.030
cellular macromolecular complex assemblyGO:00346223240.028
dna duplex unwindingGO:0032508300.028
positive regulation of developmental processGO:00510943140.028
protein import into nucleusGO:00066061040.027
immune responseGO:00069553070.027
Mouse
regulation of dna methylationGO:004403020.027
negative regulation of cell cycle g2 m phase transitionGO:1902750100.026
posttranscriptional regulation of gene expressionGO:00106082130.026
peptidyl lysine modificationGO:00182051440.026
dna replication independent nucleosome assemblyGO:0006336270.026
lipid metabolic processGO:00066293810.025
reproductive system developmentGO:0061458560.025
purine nucleotide biosynthetic processGO:0006164840.025
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002460400.025
Mouse
intrinsic apoptotic signaling pathway by p53 class mediatorGO:0072332370.025
mrna processingGO:00063971330.024
cellular response to peptide hormone stimulusGO:0071375560.024
t cell activationGO:0042110990.024
hematopoietic or lymphoid organ developmentGO:00485341860.024
purine nucleoside catabolic processGO:00061523980.023
regulation of dna repairGO:0006282470.023
metaphase plate congressionGO:0051310180.023
organelle localizationGO:0051640840.023
protein alkylationGO:0008213740.023
dna catabolic process exonucleolyticGO:0000738170.023
histone threonine phosphorylationGO:003540570.023
positive regulation of cytoplasmic transportGO:1903651820.022
neuron apoptotic processGO:0051402390.022
cellular response to peptideGO:1901653590.022
peptidyl serine phosphorylationGO:00181051010.022
organic acid biosynthetic processGO:0016053970.022
regulation of transcription by chromatin organizationGO:003440110.022
multicellular organism reproductionGO:0032504420.021
regulation of chromatin modificationGO:1903308510.021
regulation of chromatin organizationGO:1902275560.021
detection of stimulusGO:0051606850.021
ribonucleotide biosynthetic processGO:0009260810.021
posttranscriptional gene silencing by rnaGO:0035194250.021
sex differentiationGO:0007548450.021
cellular protein complex assemblyGO:00436231880.020
endocytosisGO:00068971590.020
single organism cellular localizationGO:19025803320.020
organophosphate catabolic processGO:00464344300.020
positive regulation of apoptotic processGO:00430652460.019
meiotic chromosome separationGO:005130730.019
immunoglobulin mediated immune responseGO:0016064100.019
Mouse
stem cell differentiationGO:0048863930.019
interspecies interaction between organismsGO:00444191560.019
cellular response to external stimulusGO:00714961110.018
protein methylationGO:0006479740.018
positive regulation of cell proliferationGO:00082843010.018
positive regulation of cellular component organizationGO:00511303760.018
regulation of protein acetylationGO:1901983250.018
internal peptidyl lysine acetylationGO:0018393970.018
signal transduction in response to dna damageGO:0042770570.017
response to steroid hormoneGO:0048545800.017
cellular response to organic cyclic compoundGO:00714071270.017
tissue regenerationGO:004224630.017
regulation of cellular carbohydrate metabolic processGO:0010675470.017
dna synthesis involved in dna repairGO:000073160.017
response to drugGO:0042493810.017
regulation of protein maturationGO:19033171500.017
nucleoside biosynthetic processGO:0009163260.017
histone modificationGO:00165702510.017
neuron deathGO:0070997650.017
sexual reproductionGO:0019953370.017
establishment of protein localization to organelleGO:00725941720.016
response to woundingGO:00096111680.016
negative regulation of meiosisGO:004583510.016
small gtpase mediated signal transductionGO:0007264780.016
neuron developmentGO:00486661130.016
negative regulation of cell divisionGO:0051782310.016
positive regulation of dna damage response signal transduction by p53 class mediatorGO:004351780.016
protein localization to organelleGO:00333652800.016
positive regulation of transportGO:00510503360.015
multi organism reproductive processGO:0044703540.015
molting cycleGO:0042303280.015
gene silencing by rnaGO:0031047260.015
viral processGO:00160321460.015
regulation of multi organism processGO:00439001570.015
sensory organ developmentGO:0007423520.015
positive regulation of response to dna damage stimulusGO:2001022430.015
growthGO:00400072020.015
cellular response to insulin stimulusGO:0032869410.015
nucleic acid transportGO:0050657390.014
dna replication dependent nucleosome assemblyGO:0006335320.014
regulation of histone acetylationGO:0035065190.014
neurogenesisGO:00220081690.014
pattern specification processGO:0007389430.014
dna templated transcription elongationGO:0006354250.014
carbohydrate metabolic processGO:00059752070.014
protein processingGO:00164852260.014
head developmentGO:00603221080.014
immune effector processGO:00022521590.014
Mouse
protein acetylationGO:00064731160.014
tube developmentGO:00352951250.014
reproductive structure developmentGO:0048608550.014
leading strand elongationGO:000627210.014
ras protein signal transductionGO:0007265730.014
cell type specific apoptotic processGO:00972851250.014
viral genome replicationGO:0019079500.013
activation of cysteine type endopeptidase activityGO:0097202570.013
purine ribonucleoside triphosphate catabolic processGO:00092073910.013
protein modification by small protein conjugationGO:00324463420.013
b cell activation involved in immune responseGO:000231250.013
Mouse
actin cytoskeleton organizationGO:00300362070.013
regulation of histone modificationGO:0031056470.013
regulation of cytokine productionGO:00018172320.013
protein targeting to nucleusGO:00447441040.013
muscle contractionGO:0006936730.013
response to insulinGO:0032868450.013
spermatid developmentGO:000728640.013
negative regulation of g2 m transition of mitotic cell cycleGO:001097290.013
oocyte developmentGO:004859910.013
peptidyl serine modificationGO:00182091060.013
positive regulation of protein phosphorylationGO:00019343130.012
positive regulation of transcription initiation from rna polymerase ii promoterGO:006026140.012
response to uv bGO:0010224100.012
epithelium developmentGO:00604292270.012
protein importGO:00170381300.012
single organism nuclear importGO:19025931040.012
regulation of cell cycle g1 s phase transitionGO:1902806420.012
regulation of neuron apoptotic processGO:0043523350.012
hematopoietic stem cell differentiationGO:006021840.012
nucleus organizationGO:0006997280.012
positive regulation of immune system processGO:00026842830.012
regulation of cell motilityGO:20001452990.012
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediatorGO:0042771230.012
dna damage response signal transduction by p53 class mediatorGO:0030330440.012
regulation of heart growthGO:006042040.012
establishment of rna localizationGO:0051236390.012
regulation of cellular component movementGO:00512703340.011
response to cytokineGO:00340972320.011
nls bearing protein import into nucleusGO:000660720.011
cardiac muscle cell contractionGO:008600340.011
system processGO:00030083490.011
nitrogen compound transportGO:00717051910.011
multicellular organismal reproductive processGO:0048609400.011
mrna metabolic processGO:00160711750.011
regulation of cellular component biogenesisGO:00440872810.011
hexose metabolic processGO:0019318550.011
regulation of g2 m transition of mitotic cell cycleGO:0010389200.011
regulation of sequence specific dna binding transcription factor activityGO:00510902110.011
neuron differentiationGO:00301821380.011
gmp metabolic processGO:004603740.011
tissue homeostasisGO:0001894630.011
cellular response to ionizing radiationGO:0071479320.011
regulation of peptidyl lysine acetylationGO:2000756220.011
cellular component disassemblyGO:0022411920.011
regulation of cell cycle g2 m phase transitionGO:1902749220.011
striated muscle contractionGO:0006941520.010
male meiosisGO:000714010.010
spindle organizationGO:0007051530.010
regulation of cytoskeleton organizationGO:00514931770.010
nuclear importGO:00511701060.010
purine ribonucleotide biosynthetic processGO:0009152790.010
regulation of intracellular transportGO:00323861950.010
regulation of protein processingGO:00706131500.010
cellular protein catabolic processGO:00442572610.010
regulation of sarcomere organizationGO:006029730.010

MSH6 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:145661740.611
bone marrow diseaseDOID:4961310.127
hematopoietic system diseaseDOID:741000.127
anemiaDOID:2355550.127
congenital hypoplastic anemiaDOID:1342260.127
immune system diseaseDOID:29141550.127
aplastic anemiaDOID:12449300.127
cancerDOID:1621670.127
organ system cancerDOID:00506861640.045
disease of metabolismDOID:00146672950.045
reproductive organ cancerDOID:193230.000
female reproductive organ cancerDOID:120100.000
uterine cancerDOID:36340.000
endometrial cancerDOID:138040.000
endometrial carcinomaDOID:287140.000