Homo sapiens

13 known processes

SPG7

spastic paraplegia 7 (pure and complicated autosomal recessive)

(Aliases: SPG5C,CMAR,PGN,CAR,FLJ37308,MGC126332,MGC126331)

SPG7 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
protein modification by small protein conjugationGO:00324463420.134
post embryonic developmentGO:000979120.117
cellular amine metabolic processGO:0044106410.106
chromatin modificationGO:00165682980.097
histone modificationGO:00165702510.092
cellular ketone metabolic processGO:0042180800.080
cellular amino acid metabolic processGO:00065201160.079
amine metabolic processGO:0009308440.079
regulation of cellular ketone metabolic processGO:0010565500.066
regulation of cellular amine metabolic processGO:0033238110.064
regulation of cellular amino acid metabolic processGO:000652160.061
protein ubiquitinationGO:00165673140.056
rab protein signal transductionGO:003248240.055
ras protein signal transductionGO:0007265730.050
glycosyl compound catabolic processGO:19016584130.046
regulation of transferase activityGO:00513383550.045
nervous system developmentGO:00073992930.043
segmentationGO:003528240.042
carbohydrate metabolic processGO:00059752070.042
mrna metabolic processGO:00160711750.041
memoryGO:000761330.038
epithelium developmentGO:00604292270.038
purine nucleoside triphosphate metabolic processGO:00091444120.037
defense responseGO:00069523150.037
oogenesisGO:004847720.037
blastoderm segmentationGO:000735020.037
actin filament based movementGO:0030048170.036
positive regulation of cellular amino acid metabolic processGO:004576430.035
mitotic cell cycle processGO:19030472860.035
nucleoside catabolic processGO:00091644080.035
positive regulation of cellular catabolic processGO:00313312840.035
purine ribonucleoside metabolic processGO:00461284370.035
positive regulation of developmental processGO:00510943140.034
covalent chromatin modificationGO:00165692540.033
positive regulation of purine nucleotide metabolic processGO:19005442270.033
regulation of nucleoside metabolic processGO:00091182090.033
purine ribonucleoside triphosphate metabolic processGO:00092054110.033
gtp metabolic processGO:00460392390.033
rna processingGO:00063962550.032
ribonucleoside triphosphate catabolic processGO:00092033910.032
microtubule based processGO:00070172100.032
negative regulation of apoptotic processGO:00430663160.031
positive regulation of nucleotide metabolic processGO:00459812300.031
ribonucleotide catabolic processGO:00092614050.031
membrane organizationGO:00610242920.030
negative regulation of cellular protein metabolic processGO:00322693530.030
negative regulation of programmed cell deathGO:00430693210.030
positive regulation of catabolic processGO:00098963100.029
purine nucleoside triphosphate catabolic processGO:00091463920.029
regulation of purine nucleotide catabolic processGO:00331212050.029
negative regulation of cell deathGO:00605483450.029
organophosphate catabolic processGO:00464344300.029
positive regulation of gtp catabolic processGO:00331261660.028
compound eye developmentGO:004874910.028
signal transduction by phosphorylationGO:00230142970.028
female gamete generationGO:000729220.028
regulation of kinase activityGO:00435493140.027
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.027
single organism cellular localizationGO:19025803320.027
protein polyubiquitinationGO:00002091100.027
neurogenesisGO:00220081690.027
response to oxygen containing compoundGO:19017003690.027
neuromuscular junction developmentGO:000752830.026
ribonucleoside triphosphate metabolic processGO:00091994120.026
actin filament based processGO:00300292240.026
cellular macromolecule catabolic processGO:00442653800.026
cytoplasmic transportGO:00164823790.026
regulation of protein serine threonine kinase activityGO:00719001790.026
system processGO:00030083490.025
regulation of rab protein signal transductionGO:0032483390.025
generation of neuronsGO:00486991520.025
cell projection organizationGO:00300302520.025
dna repairGO:00062811980.025
regulation of mapk cascadeGO:00434082620.025
regulation of locomotionGO:00400123290.025
regulation of protein kinase activityGO:00458592890.025
guanosine containing compound catabolic processGO:19010692390.025
histone phosphorylationGO:0016572160.025
mapk cascadeGO:00001652880.025
negative regulation of protein metabolic processGO:00512483910.024
negative regulation of developmental processGO:00510932470.024
negative regulation of multicellular organismal processGO:00512413170.024
response to virusGO:00096151260.024
organic hydroxy compound metabolic processGO:19016151470.024
regulation of cell differentiationGO:00455953930.024
negative regulation of locomotionGO:00400131180.024
mitochondrion organizationGO:00070051560.024
regulation of rab gtpase activityGO:0032313390.024
purine ribonucleoside triphosphate catabolic processGO:00092073910.024
long term memoryGO:000761620.024
small gtpase mediated signal transductionGO:0007264780.024
multicellular organismal agingGO:001025930.023
oocyte differentiationGO:000999420.023
locomotory behaviorGO:000762610.023
negative regulation of cell migrationGO:00303361020.023
positive regulation of cellular amine metabolic processGO:003324070.023
negative regulation of cellular amine metabolic processGO:003323930.023
nucleoside triphosphate metabolic processGO:00091414220.023
positive regulation of cellular component organizationGO:00511303760.023
nucleotide catabolic processGO:00091664080.023
cellular homeostasisGO:00197251960.022
regenerationGO:003109940.022
regulation of response to external stimulusGO:00321012220.022
ribonucleoside catabolic processGO:00424544060.022
organelle fissionGO:00482851490.022
regulation of cellular component movementGO:00512703340.022
purine containing compound catabolic processGO:00725234110.022
regulation of cell migrationGO:00303342890.022
actin cytoskeleton organizationGO:00300362070.022
nucleoside phosphate catabolic processGO:19012924120.022
negative regulation of cellular component movementGO:00512711060.022
single organism carbohydrate metabolic processGO:00447231930.021
organonitrogen compound biosynthetic processGO:19015662000.021
negative regulation of cellular amino acid metabolic processGO:004576320.021
positive regulation of gtpase activityGO:00435471660.021
regulation of purine nucleotide metabolic processGO:19005422640.021
negative regulation of catalytic activityGO:00430863350.021
regulation of ras protein signal transductionGO:00465781550.021
regulation of nucleotide catabolic processGO:00308112050.021
regulation of cell motilityGO:20001452990.021
single organism membrane organizationGO:00448022680.020
positive regulation of phosphorylationGO:00423273940.020
positive regulation of purine nucleotide catabolic processGO:00331231850.020
negative regulation of phosphate metabolic processGO:00459362670.020
regulation of cell morphogenesisGO:00226041530.020
growthGO:00400072020.020
hindbrain developmentGO:003090230.019
purine nucleoside catabolic processGO:00061523980.019
cell morphogenesisGO:00009022960.019
cell adhesionGO:00071553250.019
negative regulation of protein modification processGO:00314002000.019
negative regulation of cell motilityGO:20001461040.019
response to external biotic stimulusGO:00432072610.019
mitotic cell cycleGO:00002783260.019
positive regulation of rab gtpase activityGO:0032851390.019
rhythmic behaviorGO:000762220.019
epithelial cell differentiationGO:00308551410.018
determination of adult lifespanGO:000834020.018
vesicle mediated transportGO:00161923710.018
regulation of small gtpase mediated signal transductionGO:00510561560.018
lipid metabolic processGO:00066293810.018
cellular protein catabolic processGO:00442572610.018
microtubule based movementGO:0007018320.018
response to biotic stimulusGO:00096072760.018
purine nucleotide catabolic processGO:00061954050.018
regulation of cell cycleGO:00517263930.018
oocyte developmentGO:004859910.018
sex determinationGO:000753030.018
regulation of nucleotide metabolic processGO:00061402690.018
purine ribonucleoside catabolic processGO:00461303980.017
apoptotic signaling pathwayGO:00971902680.017
positive regulation of hydrolase activityGO:00513453310.017
rna splicingGO:00083801310.017
secretion by cellGO:00329402260.017
protein acylationGO:00435431380.017
mitotic nuclear divisionGO:00070671190.017
convergent extensionGO:006002610.017
regulation of response to woundingGO:19030341010.017
regulation of anatomical structure morphogenesisGO:00226032860.017
positive regulation of nucleoside metabolic processGO:00459791860.017
regulation of multi organism processGO:00439001570.017
nucleoside triphosphate catabolic processGO:00091433940.017
g protein coupled receptor signaling pathwayGO:00071862070.016
nitrogen compound transportGO:00717051910.016
negative regulation of intracellular signal transductionGO:19025321830.016
cell part morphogenesisGO:00329901370.016
cellular component morphogenesisGO:00329893140.016
defense response to other organismGO:00985421290.016
positive regulation of transferase activityGO:00513472270.016
norepinephrine transportGO:001587410.016
cellular lipid metabolic processGO:00442553030.016
enzyme linked receptor protein signaling pathwayGO:00071673030.015
protein acetylationGO:00064731160.015
cell divisionGO:00513011680.015
protein catabolic processGO:00301633250.015
negative regulation of phosphorylationGO:00423261740.015
regulation of defense responseGO:00313471540.014
positive regulation of nucleotide catabolic processGO:00308131850.014
immune effector processGO:00022521590.014
glycerolipid metabolic processGO:00464861070.014
immune responseGO:00069553070.014
regulation of cell adhesionGO:00301551660.014
blood vessel developmentGO:00015681720.014
organelle localizationGO:0051640840.014
positive regulation of cell deathGO:00109422630.014
positive regulation of programmed cell deathGO:00430682490.014
hexose metabolic processGO:0019318550.014
protein localization to membraneGO:00726571600.014
cell developmentGO:00484683280.014
cellular macromolecular complex assemblyGO:00346223240.014
morphogenesis of embryonic epitheliumGO:001633140.014
neuron projection regenerationGO:003110210.014
monosaccharide metabolic processGO:0005996740.014
posttranscriptional regulation of gene expressionGO:00106082130.014
chromatin organizationGO:00063253510.014
biological adhesionGO:00226103310.014
circadian behaviorGO:004851220.013
regulation of dna metabolic processGO:00510521530.013
tube morphogenesisGO:0035239950.013
cell morphogenesis involved in differentiationGO:00009041440.013
regulation of gtp catabolic processGO:00331241800.013
positive regulation of apoptotic processGO:00430652460.013
peptidyl tyrosine phosphorylationGO:00181081700.013
regulation of gtpase activityGO:00430871800.013
protein maturationGO:00516042330.013
protein processingGO:00164852260.013
nuclear divisionGO:00002801280.013
microtubule cytoskeleton organizationGO:00002261760.013
alcohol metabolic processGO:00060661140.013
intracellular protein transportGO:00068862700.013
response to other organismGO:00517072610.013
purine ribonucleotide catabolic processGO:00091544040.013
cellular response to hormone stimulusGO:00328701250.013
negative regulation of phosphorus metabolic processGO:00105632670.013
ribonucleoside monophosphate metabolic processGO:00091611870.013
catecholamine secretionGO:005043210.013
circulatory system developmentGO:00723592620.013
regulation of growthGO:00400081650.013
cellular response to interleukin 12GO:007134930.013
cell migration involved in gastrulationGO:004207410.013
spermatid developmentGO:000728640.013
neurological system processGO:00508771630.012
positive regulation of immune system processGO:00026842830.012
negative regulation of protein phosphorylationGO:00019331400.012
small molecule biosynthetic processGO:00442831570.012
cell projection morphogenesisGO:00488581290.012
negative regulation of hydrolase activityGO:00513461820.012
axon regenerationGO:003110310.012
regulation of cell developmentGO:00602841610.012
secretionGO:00469032540.012
oxidation reduction processGO:00551143960.012
morphogenesis of an epitheliumGO:0002009600.012
interleukin 12 mediated signaling pathwayGO:003572230.012
mrna processingGO:00063971330.012
response to hormoneGO:00097251750.012
cellular response to dna damage stimulusGO:00069743790.012
innate immune responseGO:00450871780.012
regulation of protein localizationGO:00328802960.012
rna 3 end processingGO:0031123350.012
inner ear morphogenesisGO:004247240.012
lipid transportGO:0006869900.012
dephosphorylationGO:00163112090.012
response to axon injuryGO:004867810.011
cell cycle phase transitionGO:00447701730.011
regulation of rna splicingGO:0043484620.011
neural tube closureGO:000184330.011
ossificationGO:00015031210.011
anterior posterior axis specificationGO:000994820.011
neuroblast proliferationGO:000740540.011
negative regulation of organelle organizationGO:00106391260.011
proteasomal protein catabolic processGO:00104981760.011
mitochondrial transportGO:0006839600.011
positive regulation of cell proliferationGO:00082843010.011
regulation of protein transportGO:00512232130.011
cellular response to nitrogen compoundGO:19016991440.011
negative regulation of kinase activityGO:00336731060.011
transmembrane transportGO:00550853990.011
positive regulation of organelle organizationGO:00106381950.011
glycerophospholipid metabolic processGO:0006650840.011
epithelial cell proliferationGO:00506731280.011
neural tube formationGO:000184130.011
negative regulation of cellular component organizationGO:00511292350.011
protein autophosphorylationGO:00467771230.011
golgi vesicle transportGO:0048193800.011
response to nitrogen compoundGO:19016981840.011
neuron deathGO:0070997650.011
organelle assemblyGO:00709251760.011
cellular response to cytokine stimulusGO:00713451810.011
anatomical structure formation involved in morphogenesisGO:00486462840.011
peptidyl lysine acetylationGO:00183941010.011
regulation of proteolysisGO:00301622930.011
mitochondrial membrane organizationGO:0007006400.011
regulation of cellular response to stressGO:00801352440.011
positive regulation of cell adhesionGO:0045785840.011
retrograde transport endosome to golgiGO:0042147450.011
regulation of cellular component biogenesisGO:00440872810.011
positive regulation of cell differentiationGO:00455972110.011
endosomal transportGO:00161971290.010
negative regulation of cell proliferationGO:00082852280.010
tripartite regional subdivisionGO:000735120.010
metencephalon developmentGO:002203720.010
rho protein signal transductionGO:0007266260.010
cellular response to oxygen containing compoundGO:19017012760.010
regulation of cell projection organizationGO:00313441070.010
protein targetingGO:00066051870.010
lipoprotein biosynthetic processGO:0042158330.010
defense response to virusGO:0051607710.010
chemical homeostasisGO:00488783060.010
monocarboxylic acid metabolic processGO:00327871850.010
organophosphate biosynthetic processGO:00904071630.010
purine ribonucleoside monophosphate metabolic processGO:00091671860.010
response to fungusGO:000962040.010
establishment of organelle localizationGO:0051656590.010
spermatid differentiationGO:004851540.010

SPG7 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:172230.034
disease of metabolismDOID:00146672950.024
inherited metabolic disorderDOID:6552420.024
muscular diseaseDOID:00800001140.021
muscle tissue diseaseDOID:661130.019
myopathyDOID:4231040.018
nervous system diseaseDOID:8634310.017
sensory system diseaseDOID:00501552030.017
central nervous system diseaseDOID:3311860.013
eye diseaseDOID:56141490.013
eye and adnexa diseaseDOID:14921500.013
retinal diseaseDOID:56791180.010
paraplegiaDOID:607190.002
hereditary spastic paraplegiaDOID:2476190.002