Homo sapiens

34 known processes

PNPLA3

patatin-like phospholipase domain containing 3

(Aliases: C22orf20,iPLA(2)epsilon,ADPN)

PNPLA3 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular ketone metabolic processGO:0042180800.076
cellular amino acid metabolic processGO:00065201160.073
post embryonic developmentGO:000979120.072
cellular amine metabolic processGO:0044106410.068
amine metabolic processGO:0009308440.065
positive regulation of cellular amino acid metabolic processGO:004576430.065
lipid metabolic processGO:00066293810.063
cellular lipid metabolic processGO:00442553030.062
regulation of cellular ketone metabolic processGO:0010565500.062
regulation of cellular amino acid metabolic processGO:000652160.061
regulation of cellular amine metabolic processGO:0033238110.060
transmembrane transportGO:00550853990.055
lipid biosynthetic processGO:00086101770.053
determination of adult lifespanGO:000834020.052
Fly
multicellular organismal agingGO:001025930.052
Fly
monocarboxylic acid metabolic processGO:00327871850.049
anion transportGO:00068201610.048
positive regulation of cellular amine metabolic processGO:003324070.047
female gamete generationGO:000729220.045
organic hydroxy compound metabolic processGO:19016151470.044
ras protein signal transductionGO:0007265730.044
metal ion transportGO:00300012720.043
oxidation reduction processGO:00551143960.043
organophosphate catabolic processGO:00464344300.043
purine containing compound catabolic processGO:00725234110.043
small molecule biosynthetic processGO:00442831570.042
system processGO:00030083490.041
purine nucleoside catabolic processGO:00061523980.041
ribonucleoside triphosphate catabolic processGO:00092033910.041
positive regulation of catabolic processGO:00098963100.041
Human
positive regulation of cellular component organizationGO:00511303760.041
purine nucleoside triphosphate metabolic processGO:00091444120.040
nucleoside phosphate catabolic processGO:19012924120.040
cytoplasmic transportGO:00164823790.040
locomotory behaviorGO:000762610.039
nucleoside triphosphate catabolic processGO:00091433940.039
regenerationGO:003109940.039
oogenesisGO:004847720.038
carbohydrate metabolic processGO:00059752070.038
chemical homeostasisGO:00488783060.038
Fly
organic anion transportGO:00157111030.037
negative regulation of protein metabolic processGO:00512483910.037
nucleoside triphosphate metabolic processGO:00091414220.037
ribonucleoside triphosphate metabolic processGO:00091994120.037
cation transportGO:00068123310.037
purine ribonucleotide catabolic processGO:00091544040.036
purine ribonucleoside catabolic processGO:00461303980.036
neuromuscular junction developmentGO:000752830.035
positive regulation of hydrolase activityGO:00513453310.035
positive regulation of phosphorylationGO:00423273940.035
nucleoside catabolic processGO:00091644080.035
alcohol metabolic processGO:00060661140.035
lipid catabolic processGO:0016042840.034
cellular macromolecule catabolic processGO:00442653800.034
negative regulation of catalytic activityGO:00430863350.034
purine ribonucleoside metabolic processGO:00461284370.033
organonitrogen compound biosynthetic processGO:19015662000.033
regulation of locomotionGO:00400123290.033
negative regulation of cellular protein metabolic processGO:00322693530.033
protein maturationGO:00516042330.033
purine nucleoside triphosphate catabolic processGO:00091463920.032
single organism membrane organizationGO:00448022680.032
negative regulation of cellular amine metabolic processGO:003323930.032
protein processingGO:00164852260.032
intracellular protein transportGO:00068862700.032
single organism cellular localizationGO:19025803320.032
ribonucleotide catabolic processGO:00092614050.032
reactive nitrogen species metabolic processGO:200105730.032
regulation of cellular component movementGO:00512703340.032
positive regulation of cellular catabolic processGO:00313312840.031
Human
response to oxygen containing compoundGO:19017003690.031
purine nucleotide catabolic processGO:00061954050.031
single organism carbohydrate metabolic processGO:00447231930.031
vesicle mediated transportGO:00161923710.031
ribonucleoside catabolic processGO:00424544060.031
protein catabolic processGO:00301633250.031
segmentationGO:003528240.031
negative regulation of multicellular organismal processGO:00512413170.031
nucleotide catabolic processGO:00091664080.030
purine ribonucleoside triphosphate metabolic processGO:00092054110.030
positive regulation of transportGO:00510503360.030
regulation of proteolysisGO:00301622930.030
regulation of anatomical structure morphogenesisGO:00226032860.030
nervous system developmentGO:00073992930.030
regulation of synaptic plasticityGO:004816730.030
regulation of transferase activityGO:00513383550.030
purine ribonucleoside triphosphate catabolic processGO:00092073910.029
dephosphorylationGO:00163112090.029
cellular response to endogenous stimulusGO:00714953360.029
membrane organizationGO:00610242920.029
cellular component morphogenesisGO:00329893140.029
small gtpase mediated signal transductionGO:0007264780.029
actin filament based processGO:00300292240.028
regulation of kinase activityGO:00435493140.028
guanosine containing compound catabolic processGO:19010692390.028
peripheral nervous system developmentGO:000742220.028
ion transmembrane transportGO:00342203380.027
positive regulation of apoptotic processGO:00430652460.027
negative regulation of phosphate metabolic processGO:00459362670.027
reactive oxygen species biosynthetic processGO:190340940.027
response to abiotic stimulusGO:00096283360.027
cell morphogenesisGO:00009022960.027
negative regulation of cellular amino acid metabolic processGO:004576320.027
fatty acid metabolic processGO:00066311150.027
glycosyl compound catabolic processGO:19016584130.027
cell adhesionGO:00071553250.027
positive regulation of purine nucleotide metabolic processGO:19005442270.027
gtp catabolic processGO:00061842370.027
regulation of cell motilityGO:20001452990.027
cell developmentGO:00484683280.026
regulation of nucleotide catabolic processGO:00308112050.026
negative regulation of cell deathGO:00605483450.026
negative regulation of cellular component organizationGO:00511292350.026
cellular response to oxygen containing compoundGO:19017012760.026
positive regulation of organelle organizationGO:00106381950.026
positive regulation of nucleotide metabolic processGO:00459812300.026
regulation of protein kinase activityGO:00458592890.026
regulation of cell cycleGO:00517263930.026
cellular response to dna damage stimulusGO:00069743790.026
positive regulation of cell deathGO:00109422630.026
regulation of nucleotide metabolic processGO:00061402690.026
rho protein signal transductionGO:0007266260.026
negative regulation of phosphorus metabolic processGO:00105632670.026
ion homeostasisGO:00508012300.025
response to axon injuryGO:004867810.025
regulation of response to external stimulusGO:00321012220.025
regulation of establishment of protein localizationGO:00702012420.025
positive regulation of purine nucleotide catabolic processGO:00331231850.025
regulation of nucleoside metabolic processGO:00091182090.025
regulation of cell differentiationGO:00455953930.024
small molecule catabolic processGO:0044282920.024
morphogenesis of embryonic epitheliumGO:001633140.024
regulation of mapk cascadeGO:00434082620.024
regulation of cellular response to stressGO:00801352440.024
maintenance of locationGO:00512351120.024
Human Fly
cation transmembrane transportGO:00986552380.024
positive regulation of developmental processGO:00510943140.024
regulation of protein localizationGO:00328802960.024
reactive oxygen species metabolic processGO:0072593750.024
myoblast fusionGO:000752010.024
positive regulation of protein phosphorylationGO:00019343130.023
cellular lipid catabolic processGO:0044242650.023
syncytium formation by plasma membrane fusionGO:000076820.023
regulation of purine nucleotide metabolic processGO:19005422640.023
enzyme linked receptor protein signaling pathwayGO:00071673030.023
endomembrane system organizationGO:00102561960.023
immune responseGO:00069553070.023
cell projection organizationGO:00300302520.023
positive regulation of cellular component movementGO:00512721810.023
neuron projection regenerationGO:003110210.023
guanosine containing compound metabolic processGO:19010682440.023
anatomical structure formation involved in morphogenesisGO:00486462840.023
lipid transportGO:0006869900.023
carboxylic acid biosynthetic processGO:0046394970.023
cellular macromolecular complex assemblyGO:00346223240.023
biological adhesionGO:00226103310.023
regulation of cellular component biogenesisGO:00440872810.023
negative regulation of transportGO:00510511760.022
positive regulation of cell differentiationGO:00455972110.022
inorganic cation transmembrane transportGO:00986621940.022
protein localization to organelleGO:00333652800.022
mapk cascadeGO:00001652880.022
adult locomotory behaviorGO:000834410.022
carbohydrate derivative biosynthetic processGO:19011372070.022
inorganic ion transmembrane transportGO:00986602310.022
protein localization to membraneGO:00726571600.022
negative regulation of programmed cell deathGO:00430693210.022
memoryGO:000761330.022
positive regulation of gtpase activityGO:00435471660.022
protein modification by small protein conjugationGO:00324463420.022
regulation of gtpase activityGO:00430871800.022
nitrogen compound transportGO:00717051910.021
positive regulation of cell proliferationGO:00082843010.021
anion transmembrane transportGO:0098656760.021
gtp metabolic processGO:00460392390.021
regulation of reactive oxygen species metabolic processGO:2000377410.021
secretionGO:00469032540.021
negative regulation of apoptotic processGO:00430663160.021
nerve developmentGO:002167540.021
growthGO:00400072020.021
organic acid biosynthetic processGO:0016053970.021
negative regulation of synaptic transmissionGO:005080520.021
anterior posterior axis specificationGO:000994820.021
positive regulation of reactive oxygen species biosynthetic processGO:190342820.021
endosomal transportGO:00161971290.021
positive regulation of protein transportGO:00512221350.021
positive regulation of gtp catabolic processGO:00331261660.020
cellular response to organic cyclic compoundGO:00714071270.020
positive regulation of immune system processGO:00026842830.020
positive regulation of programmed cell deathGO:00430682490.020
response to activityGO:001482300.020
mitotic cell cycleGO:00002783260.020
hindbrain developmentGO:003090230.020
signal transduction by phosphorylationGO:00230142970.020
regulation of sequence specific dna binding transcription factor activityGO:00510902110.020
rhythmic behaviorGO:000762220.020
mitochondrion organizationGO:00070051560.020
somatic muscle developmentGO:000752510.020
positive regulation of locomotionGO:00400171860.020
positive regulation of transferase activityGO:00513472270.020
negative regulation of developmental processGO:00510932470.019
cellular protein catabolic processGO:00442572610.019
protein ubiquitinationGO:00165673140.019
establishment of protein localization to organelleGO:00725941720.019
regulation of ras protein signal transductionGO:00465781550.019
positive regulation of nucleotide catabolic processGO:00308131850.019
regulation of transmembrane transportGO:00347621390.019
regulation of protein maturationGO:19033171500.019
regulation of membrane potentialGO:0042391950.019
monovalent inorganic cation transportGO:00156721280.019
apoptotic signaling pathwayGO:00971902680.019
negative regulation of protein processingGO:00109551420.019
regulation of protein transportGO:00512232130.019
regulation of lipid metabolic processGO:0019216960.019
Human
organic acid transportGO:0015849650.019
defense responseGO:00069523150.019
negative regulation of intracellular signal transductionGO:19025321830.019
protein targetingGO:00066051870.019
neurological system processGO:00508771630.019
negative regulation of protein maturationGO:19033181420.019
rna processingGO:00063962550.019
mitotic cell cycle processGO:19030472860.019
negative regulation of cell proliferationGO:00082852280.019
regulation of cell migrationGO:00303342890.019
response to hormoneGO:00097251750.019
oocyte developmentGO:004859910.019
negative regulation of proteolysisGO:00458611320.018
sodium ion transportGO:0006814610.018
positive regulation of protein kinase activityGO:00458601900.018
positive regulation of nucleoside metabolic processGO:00459791860.018
circadian behaviorGO:004851220.018
organ formationGO:004864530.018
sulfur compound metabolic processGO:00067901010.018
regulation of glial cell proliferationGO:006025140.018
regulation of peptidase activityGO:00525471800.018
negative regulation of phosphorylationGO:00423261740.018
regulation of gtp catabolic processGO:00331241800.018
regulation of cell cycle processGO:00105642660.018
motor neuron axon guidanceGO:000804520.018
regulation of cell morphogenesisGO:00226041530.018
embryonic epithelial tube formationGO:000183840.018
cell growthGO:00160491600.018
regulation of cell growthGO:00015581350.018
cellular cation homeostasisGO:00300031630.018
carboxylic acid transportGO:0046942630.018
regulation of secretion by cellGO:19035301770.018
negative regulation of hydrolase activityGO:00513461820.018
actin cytoskeleton organizationGO:00300362070.018
regulation of hormone levelsGO:00108171250.017
steroid metabolic processGO:0008202940.017
cardiac muscle cell contractionGO:008600340.017
proteolysis involved in cellular protein catabolic processGO:00516032440.017
regulation of endopeptidase activityGO:00525481700.017
lipid localizationGO:00108761060.017
Human Fly
establishment of protein localization to membraneGO:00901501210.017
negative regulation of protein phosphorylationGO:00019331400.017
response to biotic stimulusGO:00096072760.017
regulation of protein catabolic processGO:00421761550.017
regulation of intracellular transportGO:00323861950.017
positive regulation of gliogenesisGO:001401540.017
regulation of purine nucleotide catabolic processGO:00331212050.017
regulation of secretionGO:00510461940.017
positive regulation of reactive oxygen species metabolic processGO:2000379240.017
negative regulation of protein modification processGO:00314002000.017
dna repairGO:00062811980.017
blastoderm segmentationGO:000735020.017
regulation of cytoskeleton organizationGO:00514931770.017
positive regulation of cell motilityGO:20001471770.017
response to woundingGO:00096111680.017
regulation of ion transportGO:00432691890.017
secretion by cellGO:00329402260.017
peptidyl tyrosine modificationGO:00182121700.017
spermatid differentiationGO:004851540.017
protein dephosphorylationGO:0006470810.016
limbic system developmentGO:002176130.016
modification dependent macromolecule catabolic processGO:00436322120.016
regulation of cell developmentGO:00602841610.016
phospholipid metabolic processGO:0006644990.016
histone modificationGO:00165702510.016
specification of organ identityGO:001009230.016
response to external biotic stimulusGO:00432072610.016
response to organic cyclic compoundGO:00140702040.016
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.016
regulation of growthGO:00400081650.016
tripartite regional subdivisionGO:000735120.016
anterior posterior axis specification embryoGO:000859520.016
positive regulation of kinase activityGO:00336742040.016
mrna metabolic processGO:00160711750.016
cation homeostasisGO:00550801890.016
posttranscriptional regulation of gene expressionGO:00106082130.016
response to fungusGO:000962040.016
organelle assemblyGO:00709251760.016
positive regulation of cellular component biogenesisGO:00440891580.016
oocyte differentiationGO:000999420.016
associative learningGO:000830610.016
cell cycle phase transitionGO:00447701730.016
negative regulation of catabolic processGO:00098951040.016
peptidyl tyrosine phosphorylationGO:00181081700.015
protein localization to plasma membraneGO:0072659930.015
cellular response to nitrogen compoundGO:19016991440.015
morphogenesis of a polarized epitheliumGO:000173830.015
carboxylic acid catabolic processGO:0046395710.015
regulation of protein complex assemblyGO:00432541470.015
cellular response to growth factor stimulusGO:00713631970.015
photoreceptor cell differentiationGO:004653020.015
organic acid catabolic processGO:0016054710.015
chromatin organizationGO:00063253510.015
cardiovascular system developmentGO:00723582620.015
regulation of dna metabolic processGO:00510521530.015
positive regulation of synaptic transmissionGO:005080640.015
organophosphate biosynthetic processGO:00904071630.015
spermatid developmentGO:000728640.015
regulation of cysteine type endopeptidase activityGO:20001161270.015
positive regulation of ras gtpase activityGO:00323201170.015
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.015
nuclear transportGO:00511691790.015
proteasomal protein catabolic processGO:00104981760.015
protein localization to nucleusGO:00345041360.015
compound eye developmentGO:004874910.015
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.015
nucleocytoplasmic transportGO:00069131760.015
positive regulation of cell migrationGO:00303351720.015
microtubule based processGO:00070172100.015
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.015
negative regulation of transferase activityGO:00513481240.015
regulation of transporter activityGO:0032409820.015
regulation of reactive oxygen species biosynthetic processGO:190342630.015
metal ion homeostasisGO:00550651690.015
modification dependent protein catabolic processGO:00199412090.015
plasma membrane organizationGO:00070091150.015
taxisGO:00423301570.015
epithelium migrationGO:00901321190.015
neural tube formationGO:000184130.015
covalent chromatin modificationGO:00165692540.015
regulation of vesicle mediated transportGO:00606271300.015
neurotransmitter secretionGO:000726940.015
purine ribonucleoside monophosphate metabolic processGO:00091671860.014
regulation of protein processingGO:00706131500.014
regulation of apoptotic signaling pathwayGO:20012331750.014
lipid modificationGO:0030258840.014
metencephalon developmentGO:002203720.014
inner ear morphogenesisGO:004247240.014
sensory perception of painGO:001923340.014
positive regulation of mapk cascadeGO:00434101900.014
monocarboxylic acid biosynthetic processGO:0072330670.014
innate immune responseGO:00450871780.014
actin filament organizationGO:00070151280.014
negative regulation of cell cycleGO:00457861930.014
ribonucleoside monophosphate metabolic processGO:00091611870.014
organic hydroxy compound biosynthetic processGO:1901617710.014
cellular chemical homeostasisGO:00550821800.014
cellular ion homeostasisGO:00068731680.014
matingGO:000761810.014
release of cytoplasmic sequestered nf kappabGO:000858840.014
regulation of ion transmembrane transportGO:00347651320.014
cellular response to hormone stimulusGO:00328701250.014
purine nucleoside monophosphate metabolic processGO:00091261860.014
glycoprotein metabolic processGO:00091001100.014
mitotic cell cycle phase transitionGO:00447721620.014
cerebellum developmentGO:002154920.014
tissue regenerationGO:004224630.014
tissue migrationGO:00901301190.014
regulation of mitotic cell cycleGO:00073461890.014
response to nitrogen compoundGO:19016981840.014
cellular carbohydrate metabolic processGO:0044262840.014
regulation of cell projection organizationGO:00313441070.014
g protein coupled receptor signaling pathwayGO:00071862070.014
regulation of actin filament based processGO:00329701410.014
atp metabolic processGO:00460341760.014
circulatory system developmentGO:00723592620.014
regulation of ras gtpase activityGO:00323181280.014
regulation of dephosphorylationGO:0035303960.014
response to other organismGO:00517072610.013
glycerolipid metabolic processGO:00464861070.013
visual behaviorGO:000763220.013
regulation of small gtpase mediated signal transductionGO:00510561560.013
regulation of response to woundingGO:19030341010.013
rna splicingGO:00083801310.013
neurogenesisGO:00220081690.013
single organism cell adhesionGO:00986021790.013
cellular amide metabolic processGO:0043603690.013
defense response to fungusGO:005083240.013
lymphocyte homeostasisGO:000226040.013
cellular response to cytokine stimulusGO:00713451810.013
response to growth factorGO:00708482050.013
negative regulation of protein kinase activityGO:0006469980.013
somitogenesisGO:000175620.013
epithelial cell migrationGO:00106311190.013
stem cell divisionGO:001714520.013
epithelium developmentGO:00604292270.013
ubiquitin dependent protein catabolic processGO:00065112060.013
salivary gland morphogenesisGO:000743540.013
regulation of cell adhesionGO:00301551660.013
regulation of oxidoreductase activityGO:0051341430.013
nucleoside monophosphate metabolic processGO:00091231910.013
negative regulation of kinase activityGO:00336731060.013
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.013
cellular protein complex assemblyGO:00436231880.013
negative regulation of growthGO:0045926970.013
primary neural tube formationGO:001402030.013
regulation of peptidyl tyrosine phosphorylationGO:00507301080.013
generation of neuronsGO:00486991520.013
long term memoryGO:000761620.013
cellular response to organonitrogen compoundGO:00714171240.013
regulation of meiotic cell cycleGO:005144540.013
tube closureGO:006060630.013
actin mediated cell contractionGO:0070252120.013
regulation of protein serine threonine kinase activityGO:00719001790.013
regulation of metal ion transportGO:00109591200.013
regulation of intracellular protein transportGO:00331571230.013
cellular homeostasisGO:00197251960.013
response to lipidGO:00339932060.013
regulation of axon guidanceGO:190266730.013
response to drugGO:0042493810.013
post embryonic organ developmentGO:004856910.013
cell cell signalingGO:00072671550.013
establishment of planar polarityGO:000173630.013
chromatin modificationGO:00165682980.013
sensory perception of smellGO:000760820.012
positive regulation of intracellular transportGO:00323881040.012
interspecies interaction between organismsGO:00444191560.012
response to organonitrogen compoundGO:00102431560.012
central nervous system developmentGO:00074171230.012
neuron developmentGO:00486661130.012
regulation of response to dna damage stimulusGO:2001020940.012
leukocyte activationGO:00453211640.012
chemotaxisGO:00069351570.012
cell fate determinationGO:000170930.012
embryonic camera type eye developmentGO:003107620.012
multicellular organismal signalingGO:0035637340.012
protein oligomerizationGO:00512591730.012
regulation of lipid biosynthetic processGO:0046890470.012
embryonic forelimb morphogenesisGO:003511540.012
positive regulation of cytokine productionGO:00018191670.012
sleepGO:003043120.012
actin filament based movementGO:0030048170.012
monosaccharide metabolic processGO:0005996740.012
symbiosis encompassing mutualism through parasitismGO:00444031560.012
ameboidal type cell migrationGO:00016671350.012
regulation of chemotaxisGO:0050920740.012
positive regulation of secretionGO:00510471160.012
behaviorGO:00076101120.012
epidermis morphogenesisGO:004873030.012
thymus developmentGO:004853830.012
regulation of immune responseGO:00507762010.012
regulation of neurotransmitter secretionGO:004692830.012
regulation of defense responseGO:00313471540.012
lysosomal transportGO:0007041330.012
spinal cord developmentGO:002151040.012
negative regulation of peptidase activityGO:0010466910.012
cdc42 protein signal transductionGO:003248840.012
positive regulation of nf kappab transcription factor activityGO:0051092810.012
peptidyl serine modificationGO:00182091060.012
neuron differentiationGO:00301821380.012
cell projection assemblyGO:00300311260.012
neural tube closureGO:000184330.012
regulation of lipid catabolic processGO:0050994230.012
Human
establishment of tissue polarityGO:000716430.012
cofactor metabolic processGO:0051186870.012
protein importGO:00170381300.011
divalent inorganic cation homeostasisGO:00725071360.011
regulation of cytokine productionGO:00018172320.011
negative regulation of cellular catabolic processGO:0031330830.011
glycoprotein biosynthetic processGO:0009101910.011
meiotic chromosome segregationGO:004513240.011
positive regulation of protein serine threonine kinase activityGO:00719021190.011
response to nutrient levelsGO:0031667810.011
forelimb morphogenesisGO:003513640.011
membrane lipid metabolic processGO:0006643530.011
testosterone biosynthetic processGO:006137020.011
rna interferenceGO:001624640.011
positive regulation of cell developmentGO:0010720920.011
wnt signaling pathwayGO:00160551560.011

PNPLA3 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.065
inherited metabolic disorderDOID:6552420.040
nervous system diseaseDOID:8634310.024
sensory system diseaseDOID:00501552030.024
central nervous system diseaseDOID:3311860.021
musculoskeletal system diseaseDOID:172230.021
eye and adnexa diseaseDOID:14921500.017
eye diseaseDOID:56141490.017
disease of cellular proliferationDOID:145661740.017
cancerDOID:1621670.017
organ system cancerDOID:00506861640.017
retinal diseaseDOID:56791180.016
connective tissue diseaseDOID:651090.015
immune system diseaseDOID:29141550.015
acquired metabolic diseaseDOID:0060158580.015
neurodegenerative diseaseDOID:12891020.013
disease of mental healthDOID:150700.013
carbohydrate metabolism diseaseDOID:0050013320.013
bone diseaseDOID:0080001880.012
amino acid metabolic disorderDOID:9252500.012