Homo sapiens

33 known processes

MLH1

mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)

(Aliases: HNPCC2,COCA2,FCC2,hMLH1,HNPCC,MGC5172)

MLH1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
somatic diversification of immune receptors via somatic mutationGO:000256611.000
Mouse
mismatch repairGO:0006298150.999
somatic recombination of immunoglobulin gene segmentsGO:001644740.985
Mouse
dna repairGO:00062811980.982
nucleotide excision repairGO:0006289310.968
cellular response to dna damage stimulusGO:00069743790.938
gene conversionGO:003582210.902
meiosis iGO:000712740.888
Yeast Zebrafish Mouse
dna catabolic process endonucleolyticGO:0000737370.866
somatic diversification of immunoglobulins involved in immune responseGO:000220830.851
Mouse
anatomical structure homeostasisGO:00602491000.847
somatic recombination of immunoglobulin genes involved in immune responseGO:000220430.800
Mouse
maintenance of dna repeat elementsGO:004357040.765
dna double strand break processingGO:0000729100.695
somatic hypermutation of immunoglobulin genesGO:001644610.688
Mouse
telomere organizationGO:0032200330.584
double strand break repair via single strand annealingGO:004500240.523
interstrand cross link repairGO:003629730.479
nucleic acid phosphodiester bond hydrolysisGO:00903051020.340
somatic diversification of immunoglobulinsGO:001644560.309
Mouse
positive regulation of helicase activityGO:005109660.303
production of molecular mediator of immune responseGO:0002440370.300
Mouse
isotype switchingGO:004519030.269
Mouse
immunoglobulin productionGO:0002377120.258
Mouse
ribonucleoside catabolic processGO:00424544060.249
Yeast
somatic diversification of immune receptorsGO:000220080.245
Mouse
dna catabolic processGO:0006308490.242
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630500.240
Mouse
chromosome segregationGO:00070591140.223
Zebrafish Mouse
dna damage checkpointGO:0000077680.216
ribonucleoside triphosphate catabolic processGO:00092033910.211
Yeast
intrinsic apoptotic signaling pathwayGO:00971931270.203
Mouse
immune responseGO:00069553070.174
Mouse
purine nucleoside monophosphate catabolic processGO:00091281580.166
Yeast
purine nucleoside catabolic processGO:00061523980.159
Yeast
double strand break repair via homologous recombinationGO:0000724500.151
protein modification by small protein conjugationGO:00324463420.147
immune effector processGO:00022521590.139
Mouse
immune system developmentGO:00025201950.138
Mouse
dna recombinationGO:0006310770.136
Yeast Zebrafish Mouse
sex determinationGO:000753030.132
regulation of dna metabolic processGO:00510521530.132
Mouse
nucleoside triphosphate catabolic processGO:00091433940.129
Yeast
ribonucleotide catabolic processGO:00092614050.124
Yeast
leukocyte activationGO:00453211640.123
Mouse
meiotic nuclear divisionGO:0007126100.123
Yeast Zebrafish Mouse
ribonucleoside monophosphate metabolic processGO:00091611870.120
Yeast
purine ribonucleoside catabolic processGO:00461303980.116
Yeast
purine nucleoside triphosphate metabolic processGO:00091444120.110
Yeast
nuclear divisionGO:00002801280.110
Yeast Zebrafish Mouse
cell activationGO:00017752130.108
Mouse
dna replicationGO:00062601160.107
glycosyl compound catabolic processGO:19016584130.101
Yeast
ribonucleoside monophosphate catabolic processGO:00091581580.100
Yeast
purine nucleoside monophosphate metabolic processGO:00091261860.099
Yeast
multicellular organismal agingGO:001025930.097
response to organic cyclic compoundGO:00140702040.097
hemopoiesisGO:00300971800.094
dna dependent dna replicationGO:0006261440.093
cell fate commitmentGO:0045165270.092
post embryonic developmentGO:000979120.091
organelle fissionGO:00482851490.085
Yeast Zebrafish Mouse
purine containing compound catabolic processGO:00725234110.085
Yeast
leukocyte activation involved in immune responseGO:0002366300.084
Mouse
chromatin modificationGO:00165682980.083
nucleoside monophosphate catabolic processGO:00091251590.080
Yeast
g2 dna damage checkpointGO:0031572260.078
carbohydrate derivative biosynthetic processGO:19011372070.077
mitotic recombinationGO:000631280.076
Mouse
neural nucleus developmentGO:0048857470.075
immunoglobulin production involved in immunoglobulin mediated immune responseGO:000238150.074
Mouse
peptidyl lysine modificationGO:00182051440.071
recombinational repairGO:0000725500.068
lymphocyte activationGO:00466491330.067
Mouse
telomere maintenanceGO:0000723320.067
meiotic cell cycle processGO:190304680.065
Yeast Zebrafish Mouse
response to uvGO:0009411730.063
covalent chromatin modificationGO:00165692540.060
nucleoside monophosphate metabolic processGO:00091231910.058
Yeast
regulation of helicase activityGO:005109580.056
nucleoside phosphate catabolic processGO:19012924120.056
Yeast
response to inorganic substanceGO:00100351270.055
nuclear transportGO:00511691790.052
female gamete generationGO:000729220.051
Mouse
nucleoside catabolic processGO:00091644080.049
Yeast
regulation of cytokine productionGO:00018172320.048
cellular macromolecule catabolic processGO:00442653800.048
Mouse
nucleocytoplasmic transportGO:00069131760.048
small molecule biosynthetic processGO:00442831570.045
regulation of body fluid levelsGO:0050878990.043
intra s dna damage checkpointGO:003157340.043
purine nucleoside triphosphate catabolic processGO:00091463920.042
Yeast
purine ribonucleoside triphosphate catabolic processGO:00092073910.041
Yeast
meiotic gene conversionGO:000631110.040
cytoplasmic transportGO:00164823790.039
purine ribonucleotide catabolic processGO:00091544040.039
Yeast
reproductionGO:0000003630.039
Yeast Zebrafish Mouse Worm
histone h3 k4 methylationGO:0051568270.036
protein acylationGO:00435431380.035
endocytosisGO:00068971590.035
development of primary male sexual characteristicsGO:0046546230.034
g2 m transition of mitotic cell cycleGO:0000086410.034
adaptive immune responseGO:0002250490.033
Mouse
purine ribonucleoside monophosphate metabolic processGO:00091671860.033
Yeast
purine ribonucleoside monophosphate catabolic processGO:00091691580.032
Yeast
cell cycle checkpointGO:00000751170.031
determination of adult lifespanGO:000834020.029
double strand break repairGO:00063021010.029
Mouse
tissue homeostasisGO:0001894630.028
secretion by cellGO:00329402260.028
dna replication independent nucleosome assemblyGO:0006336270.028
embryo development ending in birth or egg hatchingGO:0009792340.028
Worm
protein localization to organelleGO:00333652800.027
translesion synthesisGO:001998580.027
postreplication repairGO:0006301120.026
response to abiotic stimulusGO:00096283360.026
histone modificationGO:00165702510.025
single organism carbohydrate metabolic processGO:00447231930.025
single organism cellular localizationGO:19025803320.025
behavioral defense responseGO:000220900.025
blood coagulationGO:0007596760.025
intracellular mrna localizationGO:000829810.025
nucleoside triphosphate metabolic processGO:00091414220.025
Yeast
response to calcium ionGO:0051592460.024
regulation of dna replicationGO:0006275680.024
protein acetylationGO:00064731160.024
regulation of cell cycle phase transitionGO:19019871260.023
regulation of protein transportGO:00512232130.023
response to steroid hormoneGO:0048545800.023
response to radiationGO:00093141510.022
dna integrity checkpointGO:0031570710.022
carbohydrate metabolic processGO:00059752070.021
regulation of protein secretionGO:0050708860.021
response to light stimulusGO:0009416870.020
leukocyte differentiationGO:0002521980.020
negative regulation of cell cycleGO:00457861930.020
regulation of protein catabolic processGO:00421761550.019
double strand break repair via nonhomologous end joiningGO:0006303100.019
Mouse
protein polyubiquitinationGO:00002091100.019
protein processingGO:00164852260.019
cellular response to glucocorticoid stimulusGO:007138540.019
protein maturationGO:00516042330.019
protein ubiquitinationGO:00165673140.019
microtubule based processGO:00070172100.019
Mouse
internal protein amino acid acetylationGO:00064751010.018
protein oligomerizationGO:00512591730.018
regenerationGO:003109940.018
ribonucleoside triphosphate metabolic processGO:00091994120.018
Yeast
response to caffeineGO:003100030.018
telomere maintenance via recombinationGO:000072240.018
organonitrogen compound biosynthetic processGO:19015662000.018
cell projection organizationGO:00300302520.018
regulation of peptidase activityGO:00525471800.017
blastocyst developmentGO:000182430.017
blastoderm segmentationGO:000735020.017
microtubule cytoskeleton organizationGO:00002261760.017
Mouse
positive regulation of hydrolase activityGO:00513453310.017
meiotic chromosome segregationGO:004513240.017
Zebrafish Mouse
epithelial cell differentiationGO:00308551410.017
regulation of dna recombinationGO:0000018230.016
Mouse
single organism reproductive processGO:0044702980.016
Zebrafish Mouse
lipid localizationGO:00108761060.016
internal peptidyl lysine acetylationGO:0018393970.016
response to metal ionGO:0010038840.016
compound eye developmentGO:004874910.016
atp metabolic processGO:00460341760.016
Yeast
hematopoietic or lymphoid organ developmentGO:00485341860.016
response to biotic stimulusGO:00096072760.015
regulation of secretionGO:00510461940.015
amine metabolic processGO:0009308440.015
positive regulation of cellular component movementGO:00512721810.015
response to nutrient levelsGO:0031667810.015
wound healingGO:00420601150.015
negative regulation of mitotic cell cycle phase transitionGO:1901991850.015
establishment of protein localization to organelleGO:00725941720.015
response to woundingGO:00096111680.015
blood circulationGO:00080151130.014
purine ribonucleoside triphosphate metabolic processGO:00092054110.014
Yeast
somatic cell dna recombinationGO:001644460.014
Mouse
positive regulation of vesicle fusionGO:003134040.014
modification dependent protein catabolic processGO:00199412090.014
b cell mediated immunityGO:0019724100.014
Mouse
atp catabolic processGO:00062001570.014
Yeast
secretionGO:00469032540.014
metal ion homeostasisGO:00550651690.014
humoral immune responseGO:0006959490.014
mitotic cell cycle phase transitionGO:00447721620.014
regulation of protein localizationGO:00328802960.014
activation of cysteine type endopeptidase activity involved in apoptotic processGO:0006919490.013
multicellular organismal response to stressGO:003355510.013
purine ribonucleoside metabolic processGO:00461284370.013
Yeast
glycoprotein biosynthetic processGO:0009101910.013
purine nucleotide catabolic processGO:00061954050.013
Yeast
cellular response to external stimulusGO:00714961110.013
developmental process involved in reproductionGO:0003006660.013
Mouse
reciprocal meiotic recombinationGO:000713140.013
Yeast Zebrafish Mouse
meiotic cell cycleGO:0051321130.012
Yeast Zebrafish Mouse
defense responseGO:00069523150.012
negative regulation of cell cycle phase transitionGO:1901988890.012
activation of cysteine type endopeptidase activityGO:0097202570.012
non recombinational repairGO:0000726140.012
Mouse
substantia nigra developmentGO:0021762450.012
cytokine productionGO:00018162470.012
midbrain developmentGO:0030901450.012
single organism nuclear importGO:19025931040.012
anterior posterior axis specificationGO:000994820.012
regulation of endopeptidase activityGO:00525481700.012
response to extracellular stimulusGO:0009991850.012
posttranscriptional regulation of gene expressionGO:00106082130.012
negative regulation of protein maturationGO:19033181420.012
circulatory system processGO:00030131130.012
regulation of proteolysisGO:00301622930.011
chemical homeostasisGO:00488783060.011
regulation of viral processGO:00507921030.011
negative regulation of dna recombinationGO:004591060.011
Mouse
cell developmentGO:00484683280.011
Mouse
response to hormoneGO:00097251750.011
macromolecule glycosylationGO:0043413630.011
organophosphate biosynthetic processGO:00904071630.010
head developmentGO:00603221080.010
embryo developmentGO:00097901230.010
Worm
generation of precursor metabolites and energyGO:0006091680.010
actin mediated cell contractionGO:0070252120.010
lymphocyte mediated immunityGO:0002449480.010
Mouse
response to lipidGO:00339932060.010
cellular protein catabolic processGO:00442572610.010
cellular response to lipidGO:00713961270.010
regulation of intracellular transportGO:00323861950.010
peptidyl lysine acetylationGO:00183941010.010
response to cytokineGO:00340972320.010

MLH1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
immune system diseaseDOID:29141550.859
anemiaDOID:2355550.859
hematopoietic system diseaseDOID:741000.859
aplastic anemiaDOID:12449300.859
bone marrow diseaseDOID:4961310.859
disease of cellular proliferationDOID:145661740.392
cancerDOID:1621670.378
organ system cancerDOID:00506861640.378
congenital hypoplastic anemiaDOID:1342260.209
thoracic cancerDOID:5093210.132
breast cancerDOID:1612210.132
nervous system diseaseDOID:8634310.049
sensory system diseaseDOID:00501552030.049
nonsyndromic deafnessDOID:0050563500.049
auditory system diseaseDOID:2742530.049
disease of metabolismDOID:00146672950.034
reproductive organ cancerDOID:193230.029
neuropathyDOID:870520.023
female reproductive organ cancerDOID:120100.018
fanconi s anemiaDOID:13636160.014
neuromuscular diseaseDOID:440380.013
lynch syndromeDOID:388330.000