Homo sapiens

79 known processes

LRDD

leucine-rich repeats and death domain containing

(Aliases: DKFZp434D229,MGC16925,PIDD)

LRDD biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
luteolysisGO:000155430.985
dna damage checkpointGO:0000077680.536
cellular response to dna damage stimulusGO:00069743790.487
regulation of peptidase activityGO:00525471800.416
Mouse
mitotic g1 dna damage checkpointGO:0031571170.405
signal transduction involved in mitotic g1 dna damage checkpointGO:0072431100.383
intracellular signal transduction involved in g1 dna damage checkpointGO:1902400100.383
regulation of cell cycleGO:00517263930.338
signal transduction involved in mitotic dna damage checkpointGO:1902402130.325
signal transduction involved in dna damage checkpointGO:0072422150.315
response to abiotic stimulusGO:00096283360.302
regulation of mitotic cell cycleGO:00073461890.294
compound eye developmentGO:004874910.290
positive regulation of apoptotic signaling pathwayGO:2001235700.290
Mouse
positive regulation of cell cycle arrestGO:0071158230.283
positive regulation of cell cycleGO:00457871400.283
regulation of cell cycle arrestGO:0071156360.277
mitotic g1 s transition checkpointGO:0044819170.259
negative regulation of g1 s transition of mitotic cell cycleGO:2000134290.242
cell cycle arrestGO:0007050710.240
regulation of proteolysisGO:00301622930.239
Mouse
cellular response to mechanical stimulusGO:0071260390.236
determination of adult lifespanGO:000834020.236
protein processingGO:00164852260.229
Mouse
g1 dna damage checkpointGO:0044783180.228
signal transduction involved in cell cycle checkpointGO:0072395160.225
positive regulation of cell cycle processGO:00900681060.219
positive regulation of hydrolase activityGO:00513453310.214
Mouse
mitotic cell cycleGO:00002783260.208
signal transduction involved in dna integrity checkpointGO:0072401150.207
apoptotic signaling pathwayGO:00971902680.197
Mouse
negative regulation of apoptotic processGO:00430663160.195
negative regulation of mitotic cell cycleGO:00459301020.192
cell cycle checkpointGO:00000751170.185
regulation of mitotic cell cycle phase transitionGO:19019901180.184
positive regulation of apoptotic processGO:00430652460.183
Mouse
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280690.174
Mouse
activation of cysteine type endopeptidase activity involved in apoptotic processGO:0006919490.168
Mouse
regulation of cysteine type endopeptidase activityGO:20001161270.167
Mouse
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrestGO:000697790.165
g1 s transition of mitotic cell cycleGO:0000082780.162
regulation of apoptotic signaling pathwayGO:20012331750.161
Mouse
epithelium developmentGO:00604292270.156
cell cycle phase transitionGO:00447701730.156
regulation of myeloid cell differentiationGO:0045637810.155
positive regulation of peptidase activityGO:0010952880.154
Mouse
autophagic cell deathGO:004810230.151
negative regulation of mitotic cell cycle phase transitionGO:1901991850.146
dna damage response signal transduction by p53 class mediatorGO:0030330440.146
cellular macromolecule catabolic processGO:00442653800.143
mitotic cell cycle checkpointGO:0007093680.140
cellular response to abiotic stimulusGO:00712141170.138
epithelial cell differentiationGO:00308551410.138
female gamete generationGO:000729220.138
multicellular organismal agingGO:001025930.138
regulation of cell cycle processGO:00105642660.135
gas transportGO:001566930.134
negative regulation of cell deathGO:00605483450.134
melanin metabolic processGO:000658210.134
positive regulation of cell deathGO:00109422630.133
Mouse
signal transduction involved in mitotic dna integrity checkpointGO:1902403130.132
signal transduction involved in mitotic cell cycle checkpointGO:0072413130.128
regulation of cell differentiationGO:00455953930.125
regulation of myeloid leukocyte differentiationGO:0002761390.122
positive regulation of cysteine type endopeptidase activityGO:2001056790.122
Mouse
anatomical structure formation involved in morphogenesisGO:00486462840.121
negative regulation of cell cycleGO:00457861930.119
oogenesisGO:004847720.118
dna integrity checkpointGO:0031570710.116
zymogen activationGO:0031638700.112
Mouse
regulation of cell cycle phase transitionGO:19019871260.111
response to virusGO:00096151260.104
regulation of g1 s transition of mitotic cell cycleGO:2000045400.102
spermatid developmentGO:000728640.102
response to radiationGO:00093141510.101
positive regulation of defense responseGO:0031349870.100
protein autoprocessingGO:001654040.099
hematopoietic or lymphoid organ developmentGO:00485341860.098
neuron remodelingGO:001632220.096
cell type specific apoptotic processGO:00972851250.095
protein maturationGO:00516042330.093
Mouse
positive regulation of myeloid leukocyte differentiationGO:0002763240.093
cellular response to external stimulusGO:00714961110.092
regulation of saliva secretionGO:004687720.091
negative regulation of cell cycle processGO:00109481210.089
head developmentGO:00603221080.082
positive regulation of proteolysisGO:00458621420.080
Mouse
activation of cysteine type endopeptidase activityGO:0097202570.079
Mouse
response to uvGO:0009411730.076
cell cycle g1 s phase transitionGO:0044843800.075
actin filament based processGO:00300292240.074
response to tumor necrosis factorGO:0034612760.071
negative regulation of cell cycle phase transitionGO:1901988890.070
vesicle mediated transportGO:00161923710.068
regulation of immune responseGO:00507762010.066
single organism membrane organizationGO:00448022680.065
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.063
positive regulation of mesenchymal stem cell differentiationGO:200074140.063
positive regulation of innate immune responseGO:0045089790.062
mitotic dna integrity checkpointGO:0044774300.062
secretionGO:00469032540.061
protein catabolic processGO:00301633250.061
central nervous system developmentGO:00074171230.060
membrane organizationGO:00610242920.059
peripheral nervous system developmentGO:000742220.059
amide biosynthetic processGO:0043604150.058
regulation of endopeptidase activityGO:00525481700.057
Mouse
post embryonic developmentGO:000979120.056
defense response to virusGO:0051607710.056
positive regulation of cell differentiationGO:00455972110.055
cell developmentGO:00484683280.054
regulation of leukocyte differentiationGO:1902105610.053
response to light stimulusGO:0009416870.053
negative regulation of cell cycle g1 s phase transitionGO:1902807290.051
i kappab kinase nf kappab signalingGO:00072491660.050
negative regulation of developmental processGO:00510932470.049
response to mechanical stimulusGO:0009612510.047
mitotic cell cycle phase transitionGO:00447721620.046
negative regulation of catalytic activityGO:00430863350.046
regulation of cell cycle g1 s phase transitionGO:1902806420.045
glycerol transportGO:001579350.045
renal water homeostasisGO:000309140.044
generation of neuronsGO:00486991520.044
positive regulation of endopeptidase activityGO:0010950840.044
Mouse
regulation of defense responseGO:00313471540.044
protein modification by small protein conjugationGO:00324463420.043
system processGO:00030083490.043
neuron projection developmentGO:00311751060.043
segmentationGO:003528240.043
extrinsic apoptotic signaling pathway via death domain receptorsGO:0008625420.042
Mouse
regulation of macrophage differentiationGO:004564990.042
establishment or maintenance of cytoskeleton polarityGO:003095230.041
positive regulation of cellular amine metabolic processGO:003324070.040
brain developmentGO:0007420970.040
pancreatic juice secretionGO:003015740.040
cell morphogenesisGO:00009022960.040
positive regulation of cell proliferationGO:00082843010.040
cellular protein catabolic processGO:00442572610.039
regulation of i kappab kinase nf kappab signalingGO:00431221620.039
cellular response to oxygen containing compoundGO:19017012760.038
regulation of protein localizationGO:00328802960.038
positive regulation of antimicrobial humoral responseGO:000276010.038
morphogenesis of embryonic epitheliumGO:001633140.037
intrinsic apoptotic signaling pathwayGO:00971931270.037
cellular amino acid metabolic processGO:00065201160.037
signal transduction by p53 class mediatorGO:0072331720.036
proteolysis involved in cellular protein catabolic processGO:00516032440.035
positive regulation of developmental processGO:00510943140.034
myeloid leukocyte differentiationGO:0002573600.034
cranial nerve developmentGO:002154540.033
mitochondrion organizationGO:00070051560.033
antibacterial humoral responseGO:0019731240.033
positive regulation of cellular catabolic processGO:00313312840.032
organonitrogen compound biosynthetic processGO:19015662000.032
amine metabolic processGO:0009308440.032
extrinsic apoptotic signaling pathwayGO:00971911190.031
Mouse
negative regulation of intracellular signal transductionGO:19025321830.031
positive regulation of leukocyte differentiationGO:1902107370.031
immune responseGO:00069553070.031
immune effector processGO:00022521590.030
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.030
cell part morphogenesisGO:00329901370.030
nucleoside catabolic processGO:00091644080.030
inner ear morphogenesisGO:004247240.029
nervous system developmentGO:00073992930.029
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.029
response to nitric oxideGO:007173140.029
response to oxygen containing compoundGO:19017003690.029
protein ubiquitinationGO:00165673140.029
regulation of multi organism processGO:00439001570.029
cell projection morphogenesisGO:00488581290.028
cellular amine metabolic processGO:0044106410.028
positive regulation of defense response to bacteriumGO:190042610.028
regulation of neuron deathGO:1901214560.028
neuron deathGO:0070997650.028
defense response to bacteriumGO:0042742630.028
modification dependent protein catabolic processGO:00199412090.028
regulation of intracellular transportGO:00323861950.028
pharynx developmentGO:006046510.028
spermatid differentiationGO:004851540.028
regulation of response to dna damage stimulusGO:2001020940.027
purine nucleotide biosynthetic processGO:0006164840.027
negative regulation of protein metabolic processGO:00512483910.027
mitotic cell cycle processGO:19030472860.027
protein oligomerizationGO:00512591730.027
cellular response to uvGO:0034644320.027
protein localization to membraneGO:00726571600.027
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630500.026
purine ribonucleoside triphosphate metabolic processGO:00092054110.026
negative regulation of cell differentiationGO:00455961710.025
negative regulation of multicellular organismal processGO:00512413170.025
cellular response to radiationGO:0071478650.025
regulation of kinase activityGO:00435493140.025
neuron developmentGO:00486661130.025
cellular amide metabolic processGO:0043603690.025
chromatin organizationGO:00063253510.025
embryo developmentGO:00097901230.025
response to lipidGO:00339932060.024
negative regulation of cellular protein metabolic processGO:00322693530.024
negative regulation of programmed cell deathGO:00430693210.024
cellular component morphogenesisGO:00329893140.024
regulation of cellular amino acid metabolic processGO:000652160.024
ribonucleotide biosynthetic processGO:0009260810.024
negative regulation of protein maturationGO:19033181420.024
dna repairGO:00062811980.023
ribonucleoside catabolic processGO:00424544060.023
cell growthGO:00160491600.023
regulation of branching involved in ureteric bud morphogenesisGO:009018930.023
positive regulation of organelle organizationGO:00106381950.023
cellular ketone metabolic processGO:0042180800.023
single organism cellular localizationGO:19025803320.023
negative regulation of phosphorus metabolic processGO:00105632670.023
extraocular skeletal muscle developmentGO:000207410.023
regulation of cellular response to stressGO:00801352440.022
endodermal cell fate commitmentGO:000171140.022
photoreceptor cell differentiationGO:004653020.022
response to oxidative stressGO:00069791210.022
regulation of cellular amine metabolic processGO:0033238110.022
nucleotide biosynthetic processGO:00091651090.021
positive regulation of cellular amino acid metabolic processGO:004576430.021
microtubule based processGO:00070172100.021
nucleoside triphosphate metabolic processGO:00091414220.021
cellular macromolecular complex assemblyGO:00346223240.021
blastoderm segmentationGO:000735020.021
neuron apoptotic processGO:0051402390.021
positive regulation of purine nucleotide metabolic processGO:19005442270.021
embryonic epithelial tube formationGO:000183840.021
positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathwayGO:200126910.020
positive regulation of nucleotide metabolic processGO:00459812300.020
nephron tubule formationGO:007207910.020
response to hormoneGO:00097251750.020
response to biotic stimulusGO:00096072760.020
positive regulation of phosphorylationGO:00423273940.020
purine ribonucleotide biosynthetic processGO:0009152790.020
cellular response to endogenous stimulusGO:00714953360.020
negative regulation of proteolysisGO:00458611320.020
organophosphate biosynthetic processGO:00904071630.020
organ morphogenesisGO:00098871470.020
positive regulation of programmed cell deathGO:00430682490.020
Mouse
purine nucleoside triphosphate metabolic processGO:00091444120.020
cellular lipid metabolic processGO:00442553030.020
developmental programmed cell deathGO:001062330.020
transmembrane transportGO:00550853990.020
cellular response to reactive oxygen speciesGO:0034614500.020
immune system developmentGO:00025201950.019
neurogenesisGO:00220081690.019
nucleoside triphosphate catabolic processGO:00091433940.019
anion transportGO:00068201610.019
response to inorganic substanceGO:00100351270.019
protein polyubiquitinationGO:00002091100.019
ribonucleoside triphosphate metabolic processGO:00091994120.019
mapk cascadeGO:00001652880.019
regulation of anatomical structure morphogenesisGO:00226032860.019
chromatin modificationGO:00165682980.019
response to woundingGO:00096111680.019
hyperosmotic responseGO:000697240.019
defense response to other organismGO:00985421290.018
anterior posterior axis specification embryoGO:000859520.018
forebrain dorsal ventral pattern formationGO:002179810.018
hemopoiesisGO:00300971800.018
neuromuscular junction developmentGO:000752830.018
cyclic nucleotide biosynthetic processGO:0009190610.018
one carbon compound transportGO:001975540.018
intracellular protein transportGO:00068862700.018
symbiosis encompassing mutualism through parasitismGO:00444031560.018
organophosphate catabolic processGO:00464344300.018
carbon dioxide transportGO:001567030.017
microtubule cytoskeleton organizationGO:00002261760.017
cellular response to hydrogen peroxideGO:0070301370.017
cell morphogenesis involved in differentiationGO:00009041440.017
cell cell signalingGO:00072671550.017
negative regulation of phosphate metabolic processGO:00459362670.017
regulation of response to external stimulusGO:00321012220.017
oocyte differentiationGO:000999420.017
interspecies interaction between organismsGO:00444191560.017
engulfment of apoptotic cellGO:004365220.017
growthGO:00400072020.016
tissue migrationGO:00901301190.016
endomembrane system organizationGO:00102561960.016
positive regulation of macrophage differentiationGO:004565170.016
ureteric bud formationGO:006067610.016
regulation of innate immune responseGO:0045088970.016
proteasomal protein catabolic processGO:00104981760.016
metencephalon developmentGO:002203720.016
ribose phosphate biosynthetic processGO:0046390820.016
endosomal transportGO:00161971290.016
ubiquitin dependent protein catabolic processGO:00065112060.016
mitochondrial membrane organizationGO:0007006400.016
posttranscriptional regulation of gene expressionGO:00106082130.016
regulation of mapk cascadeGO:00434082620.016
reactive oxygen species metabolic processGO:0072593750.016
cytoplasmic transportGO:00164823790.015
meiosis iGO:000712740.015
cellular response to cytokine stimulusGO:00713451810.015
anterior posterior axis specificationGO:000994820.015
ribonucleoside triphosphate catabolic processGO:00092033910.015
negative regulation of endopeptidase activityGO:0010951840.015
regulation of purine nucleotide catabolic processGO:00331212050.015
regulation of nucleotide metabolic processGO:00061402690.015
rna processingGO:00063962550.015
regulation of transferase activityGO:00513383550.015
antimicrobial humoral responseGO:0019730260.015
cellular protein complex assemblyGO:00436231880.015
positive regulation of neuron deathGO:1901216140.015
purine nucleoside triphosphate catabolic processGO:00091463920.015
autonomic nervous system developmentGO:004848310.015
negative regulation of hydrolase activityGO:00513461820.015
purine nucleoside catabolic processGO:00061523980.015
regulation of production of molecular mediator of immune responseGO:0002700250.015
meiotic chromosome segregationGO:004513240.015
ureter developmentGO:007218930.015
regulation of cellular ketone metabolic processGO:0010565500.015
positive regulation of reactive oxygen species biosynthetic processGO:190342820.015
pituitary gland developmentGO:002198320.014
nucleotide catabolic processGO:00091664080.014
regulation of purine nucleotide metabolic processGO:19005422640.014
erythrocyte homeostasisGO:0034101310.014
negative regulation of protein processingGO:00109551420.014
positive regulation of ureteric bud formationGO:007210710.014
atp metabolic processGO:00460341760.014
purine containing compound biosynthetic processGO:0072522880.014
myeloid cell differentiationGO:00300991170.014
regulation of protein processingGO:00706131500.014
rhythmic processGO:0048511310.014
regulation of protein transportGO:00512232130.014
regulation of nucleotide catabolic processGO:00308112050.014
endocytosisGO:00068971590.014
dephosphorylationGO:00163112090.014
establishment of protein localization to organelleGO:00725941720.014
positive regulation of immune responseGO:00507781590.014
purine ribonucleoside metabolic processGO:00461284370.014
macrophage differentiationGO:0030225110.014
nucleoside phosphate catabolic processGO:19012924120.014
epithelial fluid transportGO:004204510.014
specification of organ identityGO:001009230.014
leukocyte differentiationGO:0002521980.014
negative regulation of gliogenesisGO:001401430.013
modification dependent macromolecule catabolic processGO:00436322120.013
cyclic nucleotide metabolic processGO:0009187820.013
secretion by cellGO:00329402260.013
regulation of growthGO:00400081650.013
response to salt stressGO:000965130.013
multicellular organism reproductionGO:0032504420.013
positive regulation of transferase activityGO:00513472270.013
nucleoside monophosphate metabolic processGO:00091231910.013
glycosyl compound catabolic processGO:19016584130.013
cell projection organizationGO:00300302520.013
purine ribonucleoside monophosphate metabolic processGO:00091671860.013
regulation of nervous system developmentGO:0051960880.013
response to axon injuryGO:004867810.013
developmental process involved in reproductionGO:0003006660.013
positive regulation of catabolic processGO:00098963100.013
establishment of protein localization to membraneGO:00901501210.013
positive regulation of mapk cascadeGO:00434101900.013
regulation of body fluid levelsGO:0050878990.013
oocyte developmentGO:004859910.013
nitrogen compound transportGO:00717051910.013
organelle fissionGO:00482851490.013
regulation of nucleoside metabolic processGO:00091182090.012
negative regulation of transferase activityGO:00513481240.012
purine ribonucleoside catabolic processGO:00461303980.012
cyclic purine nucleotide metabolic processGO:0052652600.012
organ formationGO:004864530.012
positive regulation of nucleotide catabolic processGO:00308131850.012
regulation of establishment of protein localizationGO:00702012420.012
nucleoside phosphate biosynthetic processGO:19012931090.012
response to other organismGO:00517072610.012
peptidyl tyrosine phosphorylationGO:00181081700.012
regulation of cell growthGO:00015581350.012
regulation of mitochondrial membrane permeabilityGO:0046902250.012
response to drugGO:0042493810.012
positive regulation of cellular component organizationGO:00511303760.012
response to decreased oxygen levelsGO:0036293960.012
chemical homeostasisGO:00488783060.012
response to acid chemicalGO:0001101660.012
response to ionizing radiationGO:0010212650.012
regulation of cell developmentGO:00602841610.012
innate immune responseGO:00450871780.012
nephron epithelium developmentGO:0072009230.012
circulatory system developmentGO:00723592620.012
purine ribonucleoside monophosphate catabolic processGO:00091691580.012
dna recombinationGO:0006310770.012
dna biosynthetic processGO:0071897400.012
skin developmentGO:0043588760.012
cation transportGO:00068123310.012
mitotic nuclear divisionGO:00070671190.012
glial cell migrationGO:000834740.012
cell fate determinationGO:000170930.011
regulation of mesonephros developmentGO:006121730.011
somatic muscle developmentGO:000752510.011
peptidyl lysine modificationGO:00182051440.011
memoryGO:000761330.011
protein localization to organelleGO:00333652800.011
regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathwayGO:200126720.011
wound healingGO:00420601150.011
blood vessel morphogenesisGO:00485141620.011
cellular response to acid chemicalGO:0071229440.011
neural crest cell developmentGO:001403230.011
visual behaviorGO:000763220.011
neuron projection morphogenesisGO:0048812500.011
regulation of proteolysis involved in cellular protein catabolic processGO:1903050910.011
cardiovascular system developmentGO:00723582620.011
plasma membrane organizationGO:00070091150.011
lipid metabolic processGO:00066293810.011
wnt signaling pathwayGO:00160551560.011
regulation of reactive oxygen species metabolic processGO:2000377410.011
nuclear transportGO:00511691790.011
erythrocyte differentiationGO:0030218280.011
protein autophosphorylationGO:00467771230.011
ammonium transmembrane transportGO:007248850.011
syncytium formation by plasma membrane fusionGO:000076820.011
associative learningGO:000830610.011
positive regulation of mitotic cell cycleGO:0045931600.011
epidermis developmentGO:0008544590.011
cell morphogenesis involved in neuron differentiationGO:0048667440.011
cellular response to organonitrogen compoundGO:00714171240.011
purine containing compound catabolic processGO:00725234110.011
regulation of locomotionGO:00400123290.011
sensory perceptionGO:00076001030.011
atp catabolic processGO:00062001570.011
negative regulation of cell proliferationGO:00082852280.011
chromosome segregationGO:00070591140.010
cell divisionGO:00513011680.010
regulation of protein catabolic processGO:00421761550.010
regulation of cellular component biogenesisGO:00440872810.010
regulation of mesenchymal stem cell proliferationGO:190246010.010
positive regulation of response to biotic stimulusGO:0002833180.010
neuron differentiationGO:00301821380.010
apoptotic mitochondrial changesGO:0008637570.010
cellular response to decreased oxygen levelsGO:0036294510.010
sex determinationGO:000753030.010
tripartite regional subdivisionGO:000735120.010
negative regulation of protein modification processGO:00314002000.010
ion transmembrane transportGO:00342203380.010
protein deubiquitinationGO:0016579790.010
positive regulation of nucleoside metabolic processGO:00459791860.010
reactive oxygen species biosynthetic processGO:190340940.010
cell projection assemblyGO:00300311260.010
signal transduction by phosphorylationGO:00230142970.010

LRDD disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:1621670.024
disease of cellular proliferationDOID:145661740.024
organ system cancerDOID:00506861640.024
disease of metabolismDOID:00146672950.016
gastrointestinal system cancerDOID:3119520.015
sensory system diseaseDOID:00501552030.015
nervous system diseaseDOID:8634310.015
connective tissue diseaseDOID:651090.012
musculoskeletal system diseaseDOID:172230.012