Homo sapiens

277 known processes

TSC1

tuberous sclerosis 1

(Aliases: TSC,LAM,MGC86987,KIAA0243)

TSC1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
negative regulation of phosphatidylinositol 3 kinase signalingGO:001406740.977
nucleoside triphosphate catabolic processGO:00091433940.902
regulation of gtp catabolic processGO:00331241800.890
glycosyl compound catabolic processGO:19016584130.784
gtp metabolic processGO:00460392390.768
purine nucleotide catabolic processGO:00061954050.641
ras protein signal transductionGO:0007265730.631
regulation of ras gtpase activityGO:00323181280.616
regulation of purine nucleotide metabolic processGO:19005422640.563
purine ribonucleoside catabolic processGO:00461303980.562
ribonucleoside catabolic processGO:00424544060.547
cellular response to dna damage stimulusGO:00069743790.541
guanosine containing compound catabolic processGO:19010692390.536
positive regulation of gtpase activityGO:00435471660.536
cellular response to oxygen containing compoundGO:19017012760.534
Fly
ribonucleotide catabolic processGO:00092614050.533
positive regulation of purine nucleotide metabolic processGO:19005442270.516
purine nucleoside catabolic processGO:00061523980.506
nucleoside phosphate catabolic processGO:19012924120.502
nucleotide catabolic processGO:00091664080.500
positive regulation of nucleotide catabolic processGO:00308131850.490
response to oxygen containing compoundGO:19017003690.490
purine ribonucleoside triphosphate metabolic processGO:00092054110.477
purine ribonucleoside triphosphate catabolic processGO:00092073910.442
neuromuscular junction developmentGO:000752830.438
purine ribonucleotide catabolic processGO:00091544040.437
morphogenesis of embryonic epitheliumGO:001633140.431
Mouse
positive regulation of gtp catabolic processGO:00331261660.427
purine nucleoside triphosphate catabolic processGO:00091463920.419
small gtpase mediated signal transductionGO:0007264780.413
gtp catabolic processGO:00061842370.410
regulation of nucleoside metabolic processGO:00091182090.400
guanosine containing compound metabolic processGO:19010682440.388
regulation of protein localizationGO:00328802960.378
positive regulation of nucleoside metabolic processGO:00459791860.369
negative regulation of developmental processGO:00510932470.356
Fly
regulation of gtpase activityGO:00430871800.351
purine nucleoside triphosphate metabolic processGO:00091444120.350
positive regulation of ras gtpase activityGO:00323201170.318
regulation of cellular component biogenesisGO:00440872810.313
response to hypoxiaGO:0001666960.311
Fly
regulation of nucleotide catabolic processGO:00308112050.302
positive regulation of purine nucleotide catabolic processGO:00331231850.299
nucleoside triphosphate metabolic processGO:00091414220.298
carbohydrate transportGO:0008643370.297
Mouse
positive regulation of hydrolase activityGO:00513453310.276
negative regulation of protein metabolic processGO:00512483910.269
organophosphate catabolic processGO:00464344300.265
oogenesisGO:004847720.262
Fly
positive regulation of catabolic processGO:00098963100.256
acute phase responseGO:000695350.252
establishment of protein localization to organelleGO:00725941720.248
positive regulation of cellular catabolic processGO:00313312840.243
ribonucleoside triphosphate metabolic processGO:00091994120.235
protein localization to membraneGO:00726571600.233
protein localization to organelleGO:00333652800.229
rab protein signal transductionGO:003248240.228
response to nitrogen compoundGO:19016981840.218
purine containing compound catabolic processGO:00725234110.215
negative regulation of wnt signaling pathwayGO:0030178690.207
anatomical structure formation involved in morphogenesisGO:00486462840.204
Mouse
negative regulation of tor signalingGO:0032007110.202
regulation of transferase activityGO:00513383550.201
Mouse
defense responseGO:00069523150.198
single organism nuclear importGO:19025931040.195
tube closureGO:006060630.191
Mouse
establishment of protein localization to membraneGO:00901501210.189
monosaccharide transportGO:0015749320.185
Mouse
regulation of purine nucleotide catabolic processGO:00331212050.180
positive regulation of protein phosphorylationGO:00019343130.178
protein localization to nucleusGO:00345041360.171
positive regulation of autophagyGO:0010508240.170
Fly
nucleoside catabolic processGO:00091644080.170
nuclear transportGO:00511691790.169
hexose transportGO:0008645300.168
Mouse
chemotaxisGO:00069351570.165
primary neural tube formationGO:001402030.163
Mouse
determination of adult lifespanGO:000834020.162
Fly
glucose transportGO:0015758300.160
Mouse
regulation of kinase activityGO:00435493140.159
Mouse
nervous system developmentGO:00073992930.156
Mouse
inflammatory responseGO:0006954790.154
protein importGO:00170381300.153
regulation of nucleotide metabolic processGO:00061402690.150
cell projection organizationGO:00300302520.147
Zebrafish Mouse
tor signalingGO:0031929390.141
heart developmentGO:0007507950.139
Mouse
protein targeting to nucleusGO:00447441040.134
cellular response to hypoxiaGO:0071456510.133
Fly
cellular response to peptide hormone stimulusGO:0071375560.132
Fly
vesicle mediated transportGO:00161923710.130
cilium morphogenesisGO:0060271750.130
Zebrafish
response to decreased oxygen levelsGO:0036293960.130
Fly
protein oligomerizationGO:00512591730.127
response to organonitrogen compoundGO:00102431560.127
circulatory system developmentGO:00723592620.124
Mouse
protein homooligomerizationGO:00512601000.122
intracellular protein transportGO:00068862700.122
negative regulation of intracellular signal transductionGO:19025321830.122
neural tube formationGO:000184130.121
Mouse
acute inflammatory responseGO:0002526210.116
regulation of small gtpase mediated signal transductionGO:00510561560.112
cellular response to peptideGO:1901653590.111
Fly
taxisGO:00423301570.110
regulation of phosphatidylinositol 3 kinase signalingGO:0014066350.108
enzyme linked receptor protein signaling pathwayGO:00071673030.108
Fly
regulation of protein serine threonine kinase activityGO:00719001790.105
tube developmentGO:00352951250.103
Mouse
protein ubiquitinationGO:00165673140.102
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.099
Fly
response to nutrientGO:0007584200.099
Fly
cellular response to nitrogen compoundGO:19016991440.098
Fly
regulation of protein kinase activityGO:00458592890.097
Mouse
regulation of map kinase activityGO:00434051080.097
negative regulation of cellular protein metabolic processGO:00322693530.096
negative regulation of multicellular organismal processGO:00512413170.095
Fly
phosphatidylinositol mediated signalingGO:0048015550.095
cellular response to decreased oxygen levelsGO:0036294510.094
Fly
ribonucleoside triphosphate catabolic processGO:00092033910.093
female gamete generationGO:000729220.093
Fly
protein import into nucleusGO:00066061040.092
nuclear importGO:00511701060.092
response to peptideGO:1901652650.092
epithelium developmentGO:00604292270.091
Mouse Fly
single organism cellular localizationGO:19025803320.091
negative regulation of phosphorus metabolic processGO:00105632670.090
wnt signaling pathwayGO:00160551560.089
tissue morphogenesisGO:0048729960.089
Mouse
regulation of rab protein signal transductionGO:0032483390.088
negative regulation of catalytic activityGO:00430863350.085
nucleocytoplasmic transportGO:00069131760.085
positive regulation of rab gtpase activityGO:0032851390.083
plasma membrane organizationGO:00070091150.083
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.080
neural tube closureGO:000184330.080
Mouse
regulation of rab gtpase activityGO:0032313390.079
cytoplasmic transportGO:00164823790.078
regulation of anatomical structure sizeGO:00900661010.076
Mouse Fly
positive regulation of phosphorylationGO:00423273940.076
response to abiotic stimulusGO:00096283360.075
Fly
regulation of cellular response to insulin stimulusGO:1900076170.074
Fly
regulation of mapk cascadeGO:00434082620.073
maintenance of location in cellGO:0051651620.073
lipid metabolic processGO:00066293810.071
Fly
response to oxygen levelsGO:00704821000.071
Fly
negative regulation of cell growthGO:0030308830.071
Fly
protein localization to plasma membraneGO:0072659930.070
apoptotic signaling pathwayGO:00971902680.069
cellular response to oxygen levelsGO:0071453550.069
Fly
phosphatidylinositol 3 kinase signalingGO:0014065480.067
cellular response to endogenous stimulusGO:00714953360.067
Fly
regulation of endocytosisGO:0030100720.066
membrane organizationGO:00610242920.066
endomembrane system organizationGO:00102561960.065
protein modification by small protein conjugationGO:00324463420.065
glucose importGO:0046323240.064
Mouse
innate immune responseGO:00450871780.063
regulation of insulin receptor signaling pathwayGO:0046626130.063
Fly
cilium assemblyGO:0042384630.062
regulation of ras protein signal transductionGO:00465781550.061
inositol lipid mediated signalingGO:0048017550.061
protein targetingGO:00066051870.061
mapk cascadeGO:00001652880.059
cellular response to organonitrogen compoundGO:00714171240.055
Fly
regulation of cell growthGO:00015581350.055
Fly
negative regulation of phosphate metabolic processGO:00459362670.055
endosomal transportGO:00161971290.054
negative regulation of cilium assemblyGO:190201830.054
regulation of cell cycleGO:00517263930.053
Fly
regulation of epithelial cell proliferationGO:00506781130.052
negative regulation of epithelial cell proliferationGO:0050680480.051
signal transduction by phosphorylationGO:00230142970.050
autophagyGO:0006914880.050
Fly
cilium organizationGO:0044782680.049
negative regulation of protein modification processGO:00314002000.048
protein heterooligomerizationGO:0051291160.047
regulation of wnt signaling pathwayGO:00301111230.046
negative regulation of protein phosphorylationGO:00019331400.045
chromatin organizationGO:00063253510.045
morphogenesis of an epitheliumGO:0002009600.045
Mouse
sodium ion transportGO:0006814610.044
negative regulation of mapk cascadeGO:0043409560.044
epithelial cell proliferationGO:00506731280.044
negative regulation of map kinase activityGO:0043407270.043
regulation of sequence specific dna binding transcription factor activityGO:00510902110.042
negative regulation of developmental growthGO:0048640100.041
Fly
dna repairGO:00062811980.041
covalent chromatin modificationGO:00165692540.040
negative regulation of protein serine threonine kinase activityGO:0071901570.040
negative regulation of nervous system developmentGO:0051961280.040
histone modificationGO:00165702510.039
negative regulation of protein kinase b signalingGO:0051898170.039
protein catabolic processGO:00301633250.038
regulation of establishment of protein localizationGO:00702012420.038
response to lipidGO:00339932060.038
positive regulation of nucleotide metabolic processGO:00459812300.037
peptidyl lysine modificationGO:00182051440.037
regulation of protein kinase b signalingGO:0051896610.037
monovalent inorganic cation transportGO:00156721280.035
Mouse
regulation of protein catabolic processGO:00421761550.035
posttranscriptional regulation of gene expressionGO:00106082130.035
response to other organismGO:00517072610.034
rho protein signal transductionGO:0007266260.034
negative regulation of cellular response to insulin stimulusGO:190007780.034
Fly
positive chemotaxisGO:0050918330.034
regulation of growthGO:00400081650.033
Fly
cell cell signaling involved in cell fate commitmentGO:004516850.033
neuron differentiationGO:00301821380.033
negative regulation of transferase activityGO:00513481240.032
regulation of autophagyGO:0010506520.032
Fly
cell projection morphogenesisGO:00488581290.032
Zebrafish
regulation of cellular amino acid metabolic processGO:000652160.031
positive regulation of transportGO:00510503360.031
intracellular receptor signaling pathwayGO:00305221040.031
purine ribonucleoside metabolic processGO:00461284370.030
release of cytoplasmic sequestered nf kappabGO:000858840.030
regulation of i kappab kinase nf kappab signalingGO:00431221620.030
positive regulation of programmed cell deathGO:00430682490.030
neurogenesisGO:00220081690.029
chromatin modificationGO:00165682980.029
organ growthGO:0035265120.028
Fly
negative regulation of phosphorylationGO:00423261740.028
cell projection assemblyGO:00300311260.028
regulation of cell developmentGO:00602841610.028
regulation of cell cycle processGO:00105642660.028
negative regulation of hydrolase activityGO:00513461820.027
cell developmentGO:00484683280.027
Fly
maintenance of protein locationGO:0045185570.027
cellular component assembly involved in morphogenesisGO:0010927730.027
response to nutrient levelsGO:0031667810.027
Fly
cell fate determinationGO:000170930.026
regulation of cell differentiationGO:00455953930.026
Fly
regulation of innate immune responseGO:0045088970.026
positive regulation of cellular component organizationGO:00511303760.026
protein kinase b signalingGO:0043491690.026
system processGO:00030083490.026
Mouse
carbohydrate metabolic processGO:00059752070.025
regulation of cell morphogenesisGO:00226041530.025
negative regulation of protein transportGO:0051224750.025
regulation of defense responseGO:00313471540.025
regulation of synapse assemblyGO:005196350.025
translationGO:00064121320.025
regulation of cellular component sizeGO:0032535820.025
Mouse Fly
regulation of cellular ketone metabolic processGO:0010565500.024
cellular amino acid metabolic processGO:00065201160.024
chordate embryonic developmentGO:0043009340.024
Mouse
negative regulation of kinase activityGO:00336731060.023
cell part morphogenesisGO:00329901370.023
Zebrafish
regulation of nervous system developmentGO:0051960880.023
regulation of protein localization to nucleusGO:1900180850.023
insulin like growth factor receptor signaling pathwayGO:0048009130.023
positive regulation of cell deathGO:00109422630.023
sensory perception of painGO:001923340.022
regulation of synaptic plasticityGO:004816730.022
regulation of cellular response to stressGO:00801352440.022
regulation of vasculature developmentGO:1901342970.022
transmembrane transportGO:00550853990.022
growthGO:00400072020.021
Fly
cell cell signalingGO:00072671550.021
response to cytokineGO:00340972320.021
positive regulation of defense responseGO:0031349870.021
regulation of cell projection organizationGO:00313441070.021
regulation of response to external stimulusGO:00321012220.021
immune responseGO:00069553070.021
single organism membrane organizationGO:00448022680.021
negative regulation of response to external stimulusGO:0032102830.020
protein autophosphorylationGO:00467771230.020
reproductive processGO:00224141060.020
Fly
negative regulation of cell cycleGO:00457861930.020
cellular macromolecule catabolic processGO:00442653800.020
positive regulation of developmental processGO:00510943140.020
cell divisionGO:00513011680.020
defense response to virusGO:0051607710.020
extrinsic apoptotic signaling pathwayGO:00971911190.020
locomotory behaviorGO:000762610.020
maintenance of protein location in cellGO:0032507560.019
positive regulation of apoptotic processGO:00430652460.019
response to external biotic stimulusGO:00432072610.019
positive regulation of rho gtpase activityGO:0032321560.019
regulation of anatomical structure morphogenesisGO:00226032860.019
response to bacteriumGO:00096171440.019
amine metabolic processGO:0009308440.019
negative regulation of catabolic processGO:00098951040.019
multicellular organismal agingGO:001025930.019
Fly
positive regulation of protein transportGO:00512221350.018
cellular amine metabolic processGO:0044106410.018
negative regulation of organ growthGO:004662150.018
Fly
response to biotic stimulusGO:00096072760.018
startle responseGO:000196430.018
positive regulation of cellular amino acid metabolic processGO:004576430.018
organelle assemblyGO:00709251760.018
regulation of transporter activityGO:0032409820.018
regulation of transmembrane transportGO:00347621390.018
regulation of organelle assemblyGO:1902115400.018
regulation of protein transportGO:00512232130.018
tube morphogenesisGO:0035239950.018
Mouse
cell fate commitmentGO:0045165270.018
brain developmentGO:0007420970.018
Mouse
regulation of cell morphogenesis involved in differentiationGO:0010769830.018
epithelial tube morphogenesisGO:0060562380.018
Mouse
nitrogen compound transportGO:00717051910.017
negative regulation of cellular component organizationGO:00511292350.017
limbic system developmentGO:002176130.017
Mouse
neuron projection developmentGO:00311751060.017
cellular ketone metabolic processGO:0042180800.017
negative regulation of insulin receptor signaling pathwayGO:004662780.017
Fly
positive regulation of transcription from rna polymerase ii promoter during mitosisGO:004602210.017
serine phosphorylation of stat proteinGO:004250140.017
synapse organizationGO:0050808140.017
Mouse
post embryonic developmentGO:000979120.016
Fly
regulation of synapse organizationGO:005080770.016
phagocytosisGO:0006909420.016
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.016
response to muramyl dipeptideGO:003249540.016
protein maturationGO:00516042330.016
cell growthGO:00160491600.016
Fly
secretionGO:00469032540.016
negative regulation of protein kinase activityGO:0006469980.016
segmentationGO:003528240.015
positive regulation of cell proliferationGO:00082843010.015
regulation of protein targetingGO:1903533910.015
muscle contractionGO:0006936730.015
endocytosisGO:00068971590.015
neurological system processGO:00508771630.015
Mouse
negative regulation of programmed cell deathGO:00430693210.015
positive regulation of transcription during mitosisGO:004589720.015
cellular protein catabolic processGO:00442572610.015
phospholipid metabolic processGO:0006644990.015
dna recombinationGO:0006310770.015
cerebellum developmentGO:002154920.015
generation of precursor metabolites and energyGO:0006091680.015
establishment or maintenance of microtubule cytoskeleton polarityGO:003095120.015
histone acetylationGO:0016573930.014
amide transportGO:0042886760.014
maintenance of locationGO:00512351120.014
regulation of protein stabilityGO:0031647870.014
negative regulation of cell cycle processGO:00109481210.014
cell morphogenesisGO:00009022960.014
Zebrafish
dephosphorylationGO:00163112090.014
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.014
regulation of canonical wnt signaling pathwayGO:0060828880.014
cellular macromolecular complex assemblyGO:00346223240.014
positive regulation of protein catabolic processGO:0045732750.014
negative regulation of protein processingGO:00109551420.014
negative regulation of organelle organizationGO:00106391260.014
regulation of multi organism processGO:00439001570.014
regulation of immune responseGO:00507762010.014
negative regulation of protein localization to nucleusGO:1900181340.014
intraciliary transportGO:004207370.014
detection of muramyl dipeptideGO:003249810.014
intrinsic apoptotic signaling pathwayGO:00971931270.014
endosome to lysosome transportGO:0008333210.014
internal protein amino acid acetylationGO:00064751010.014
muscle system processGO:0003012810.013
regulation of protein import into nucleusGO:0042306780.013
regulation of protein ubiquitinationGO:0031396950.013
ion transmembrane transportGO:00342203380.013
response to uvGO:0009411730.013
cellular response to lipidGO:00713961270.013
regulation of nucleocytoplasmic transportGO:0046822980.013
negative regulation of dephosphorylationGO:0035305630.013
defense response to bacteriumGO:0042742630.013
lymphocyte homeostasisGO:000226040.013
ubiquitin dependent protein catabolic processGO:00065112060.013
peptide metabolic processGO:0006518510.013
response to virusGO:00096151260.013
jak stat cascadeGO:0007259460.013
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.013
positive regulation of cell morphogenesis involved in differentiationGO:0010770500.013
positive regulation of cytoplasmic transportGO:1903651820.013
positive regulation of intracellular transportGO:00323881040.012
compound eye developmentGO:004874910.012
i kappab kinase nf kappab signalingGO:00072491660.012
regulation of rho gtpase activityGO:0032319660.012
positive regulation of cellular amine metabolic processGO:003324070.012
stem cell differentiationGO:0048863930.012
positive regulation of mapk cascadeGO:00434101900.012
negative regulation of cellular amine metabolic processGO:003323930.012
rna splicingGO:00083801310.012
positive regulation of protein kinase activityGO:00458601900.012
intraciliary retrograde transportGO:003572130.012
metal ion transportGO:00300012720.012
Mouse
synapse assemblyGO:000741680.011
positive regulation of cell differentiationGO:00455972110.011
neural tube developmentGO:002191590.011
Mouse
defense response to other organismGO:00985421290.011
modification dependent protein catabolic processGO:00199412090.011
negative regulation of transportGO:00510511760.011
positive regulation of intracellular protein transportGO:0090316760.011
regulation of protein secretionGO:0050708860.011
positive regulation of organelle organizationGO:00106381950.011
dna damage checkpointGO:0000077680.011
regulation of intracellular transportGO:00323861950.011
positive regulation of transferase activityGO:00513472270.011
positive regulation of protein localization to nucleusGO:1900182480.011
cellular response to cytokine stimulusGO:00713451810.011
regulation of synapse structure and activityGO:005080370.011
reactive oxygen species metabolic processGO:0072593750.011
Fly
biological adhesionGO:00226103310.011
striated muscle contractionGO:0006941520.011
microtubule based processGO:00070172100.011
cell cycle phase transitionGO:00447701730.011
nuclear migrationGO:000709710.011
sodium ion transmembrane transportGO:0035725590.011
regulation of cilium assemblyGO:190201760.011
response to axon injuryGO:004867810.011
negative regulation of viral processGO:0048525660.011
metencephalon developmentGO:002203720.010
monocarboxylic acid metabolic processGO:00327871850.010
oxidation reduction processGO:00551143960.010
positive regulation of immune responseGO:00507781590.010
response to drugGO:0042493810.010
regulation of meiosisGO:004002030.010
modification dependent macromolecule catabolic processGO:00436322120.010
mitochondrion organizationGO:00070051560.010
regulation of cell projection assemblyGO:0060491470.010
cellular response to hormone stimulusGO:00328701250.010
Fly
central nervous system neuron axonogenesisGO:002195530.010
negative regulation of immune system processGO:00026831360.010
single organism carbohydrate metabolic processGO:00447231930.010
regulation of cytoplasmic transportGO:19036491490.010
regulation of transmembrane transporter activityGO:0022898740.010

TSC1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
central nervous system diseaseDOID:3311860.055
nervous system diseaseDOID:8634310.055
neurodegenerative diseaseDOID:12891020.017
cancerDOID:1621670.012
disease of cellular proliferationDOID:145661740.012
organ system cancerDOID:00506861640.012
tuberous sclerosisDOID:1351530.000