Homo sapiens

6 known processes

GRN

granulin

(Aliases: PEPI,GP88,GEP,PCDGF,PGRN)

GRN biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
neurological system processGO:00508771630.876
vacuole organizationGO:0007033440.835
epithelium developmentGO:00604292270.650
response to other organismGO:00517072610.633
protein catabolic processGO:00301633250.627
neuromuscular processGO:0050905150.616
single organism carbohydrate catabolic processGO:0044724330.604
multicellular organismal agingGO:001025930.583
system processGO:00030083490.569
carbohydrate metabolic processGO:00059752070.550
determination of adult lifespanGO:000834020.547
regulation of blood vessel remodelingGO:006031220.480
anatomical structure homeostasisGO:00602491000.446
negative regulation of multicellular organismal metabolic processGO:004425230.443
retina homeostasisGO:0001895420.423
multicellular organismal homeostasisGO:0048871670.405
signal transduction by phosphorylationGO:00230142970.384
cellular amine metabolic processGO:0044106410.358
single organism carbohydrate metabolic processGO:00447231930.349
regulation of cellular ketone metabolic processGO:0010565500.346
positive regulation of cytokine productionGO:00018191670.335
regulation of elastin catabolic processGO:006031010.327
negative regulation of elastin catabolic processGO:006031110.320
membrane lipid metabolic processGO:0006643530.315
carbohydrate catabolic processGO:0016052360.311
chemical homeostasisGO:00488783060.311
cellular amide metabolic processGO:0043603690.307
regulation of systemic arterial blood pressure by circulatory renin angiotensinGO:000199140.295
sensory perception of bitter tasteGO:0050913280.287
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.283
protein maturationGO:00516042330.265
antigen processing and presentation of peptide antigenGO:0048002180.254
locomotory behaviorGO:000762610.250
negative regulation of collagen catabolic processGO:001071110.233
nervous system developmentGO:00073992930.223
Zebrafish
cellular amino acid metabolic processGO:00065201160.200
cytokine productionGO:00018162470.191
response to bacteriumGO:00096171440.191
protein localization to organelleGO:00333652800.176
protein processingGO:00164852260.170
regulation of lipid metabolic processGO:0019216960.167
proteolysis involved in cellular protein catabolic processGO:00516032440.164
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messengerGO:0007187430.162
circulatory system developmentGO:00723592620.158
leukocyte mediated immunityGO:0002443590.150
cellular ion homeostasisGO:00068731680.149
regulation of cellular amino acid metabolic processGO:000652160.146
antigen processing and presentationGO:0019882330.145
lipid metabolic processGO:00066293810.144
innate immune responseGO:00450871780.136
involuntary skeletal muscle contractionGO:000301110.132
neuromuscular process controlling balanceGO:005088570.130
organ morphogenesisGO:00098871470.121
post embryonic developmentGO:000979120.115
tissue homeostasisGO:0001894630.100
sensory perception of tasteGO:0050909360.098
retina development in camera type eyeGO:0060041150.098
immune responseGO:00069553070.098
cellular metal ion homeostasisGO:00068751460.096
positive regulation of developmental processGO:00510943140.087
peptide catabolic processGO:0043171100.082
positive regulation of cellular amine metabolic processGO:003324070.082
cellular homeostasisGO:00197251960.081
regulation of defense responseGO:00313471540.080
collagen catabolic processGO:0030574100.079
g protein coupled receptor signaling pathwayGO:00071862070.077
regulation of leukocyte mediated immunityGO:0002703380.071
regulation of peptidase activityGO:00525471800.070
sensory perception of chemical stimulusGO:0007606380.070
cartilage development involved in endochondral bone morphogenesisGO:006035120.070
positive regulation of defense responseGO:0031349870.070
regulation of purine nucleotide metabolic processGO:19005422640.070
central nervous system developmentGO:00074171230.067
elastin catabolic processGO:006030910.067
defense responseGO:00069523150.067
cellular chemical homeostasisGO:00550821800.067
lipid catabolic processGO:0016042840.067
single organism membrane organizationGO:00448022680.066
regulation of intracellular transportGO:00323861950.064
regulation of erk1 and erk2 cascadeGO:0070372990.063
peptide metabolic processGO:0006518510.062
amino acid transportGO:0006865280.061
regulation of peptidyl tyrosine phosphorylationGO:00507301080.061
response to hormoneGO:00097251750.060
negative regulation of cell deathGO:00605483450.060
multicellular organismal metabolic processGO:0044236340.059
agingGO:0007568660.058
regulation of angiotensin levels in bloodGO:000200230.057
regulation of mapk cascadeGO:00434082620.057
cell projection organizationGO:00300302520.057
Zebrafish
regulation of secretionGO:00510461940.056
posttranscriptional regulation of gene expressionGO:00106082130.056
ossificationGO:00015031210.055
muscle contractionGO:0006936730.055
positive regulation of cell activationGO:0050867810.055
ion homeostasisGO:00508012300.054
glycogen catabolic processGO:000598040.054
ganglioside catabolic processGO:000668930.053
response to hypoxiaGO:0001666960.053
eye developmentGO:0001654420.053
response to oxygen containing compoundGO:19017003690.053
erbb signaling pathwayGO:0038127440.052
chemical homeostasis within a tissueGO:004887530.051
intracellular protein transportGO:00068862700.051
embryonic organ morphogenesisGO:0048562240.051
negative regulation of cellular protein metabolic processGO:00322693530.050
regulation of natural killer cell mediated immunityGO:0002715160.050
cellular ketone metabolic processGO:0042180800.049
nucleoside catabolic processGO:00091644080.049
cellular lipid metabolic processGO:00442553030.048
growthGO:00400072020.048
Zebrafish
hexose metabolic processGO:0019318550.048
response to biotic stimulusGO:00096072760.047
regulation of nucleotide metabolic processGO:00061402690.047
cellular cation homeostasisGO:00300031630.046
antigen processing and presentation of peptide antigen via mhc class iiGO:0002495110.046
maintenance of locationGO:00512351120.046
vesicle mediated transportGO:00161923710.044
lipid localizationGO:00108761060.043
positive regulation of cellular amino acid metabolic processGO:004576430.043
muscle tissue developmentGO:0060537620.043
detection of chemical stimulusGO:0009593550.042
regulation of systemic arterial blood pressure by hormoneGO:0001990120.042
detection of chemical stimulus involved in sensory perception of tasteGO:0050912310.042
extracellular matrix organizationGO:0030198410.041
negative regulation of peptidase activityGO:0010466910.040
ribonucleoside catabolic processGO:00424544060.040
regulation of blood pressureGO:0008217300.039
negative regulation of dendritic cell differentiationGO:200119920.039
detection of stimulus involved in sensory perceptionGO:0050906430.039
head developmentGO:00603221080.038
neuronal action potentialGO:001922890.036
gland developmentGO:0048732480.036
Zebrafish
regulation of rho gtpase activityGO:0032319660.035
negative regulation of multicellular organismal processGO:00512413170.035
nuclear transportGO:00511691790.034
negative regulation of catalytic activityGO:00430863350.034
amine metabolic processGO:0009308440.034
cellular response to hormone stimulusGO:00328701250.034
response to external biotic stimulusGO:00432072610.034
cytoplasmic transportGO:00164823790.034
peripheral nervous system developmentGO:000742220.033
cellular macromolecule catabolic processGO:00442653800.033
negative regulation of cellular component movementGO:00512711060.033
cellular lipid catabolic processGO:0044242650.033
behaviorGO:00076101120.032
protein localization to membraneGO:00726571600.032
striated muscle contractionGO:0006941520.032
heart developmentGO:0007507950.032
positive regulation of natural killer cell mediated immunityGO:0002717120.031
lymphocyte activationGO:00466491330.031
leukocyte activationGO:00453211640.031
cation transportGO:00068123310.031
positive regulation of erk1 and erk2 cascadeGO:0070374750.031
regulation of cytoplasmic transportGO:19036491490.031
monosaccharide metabolic processGO:0005996740.031
cellular response to thyroid hormone stimulusGO:009706790.030
surfactant homeostasisGO:004312930.029
regulation of cellular response to stressGO:00801352440.029
cell projection assemblyGO:00300311260.028
negative regulation of proteolysisGO:00458611320.028
negative regulation of cell motilityGO:20001461040.028
endochondral bone morphogenesisGO:006035030.028
liposaccharide metabolic processGO:1903509270.028
modification dependent protein catabolic processGO:00199412090.028
peptidyl tyrosine modificationGO:00182121700.028
organic hydroxy compound metabolic processGO:19016151470.027
proteasomal protein catabolic processGO:00104981760.027
gtp metabolic processGO:00460392390.027
protein importGO:00170381300.027
single organism nuclear importGO:19025931040.027
extracellular structure organizationGO:0043062410.027
rho protein signal transductionGO:0007266260.027
regulation of transferase activityGO:00513383550.027
regulation of protein stabilityGO:0031647870.027
negative regulation of blood vessel remodelingGO:006031310.026
actin filament based processGO:00300292240.026
metal ion homeostasisGO:00550651690.026
cell developmentGO:00484683280.026
Zebrafish
response to woundingGO:00096111680.026
purine ribonucleoside triphosphate metabolic processGO:00092054110.026
epidermis developmentGO:0008544590.025
lytic vacuole organizationGO:0080171240.025
angiotensin maturationGO:000200320.025
lysosome organizationGO:0007040240.025
regulation of rho protein signal transductionGO:0035023790.025
positive regulation of cellular component organizationGO:00511303760.024
negative regulation of hydrolase activityGO:00513461820.024
positive regulation of nucleoside metabolic processGO:00459791860.024
epithelial cell differentiationGO:00308551410.024
cellular carbohydrate metabolic processGO:0044262840.024
response to organonitrogen compoundGO:00102431560.024
negative regulation of developmental processGO:00510932470.023
t cell proliferationGO:0042098450.023
negative regulation of glycoprotein metabolic processGO:190301980.023
neuromuscular process controlling postureGO:005088420.023
brain developmentGO:0007420970.023
membrane protein proteolysisGO:0033619380.023
regulation of cell differentiationGO:00455953930.023
negative regulation of cellular response to oxidative stressGO:1900408180.022
regulation of establishment of protein localizationGO:00702012420.022
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822290.022
renal system developmentGO:0072001630.022
regulation of protein maturationGO:19033171500.021
adaptive immune responseGO:0002250490.021
muscle cell cellular homeostasisGO:004671630.021
negative regulation of programmed cell deathGO:00430693210.021
regulation of osteoblast differentiationGO:0045667380.021
glycosphingolipid metabolic processGO:0006687130.021
nuclear importGO:00511701060.020
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.020
respiratory system processGO:000301630.020
cellular protein complex assemblyGO:00436231880.020
hexose catabolic processGO:001932070.020
generation of neuronsGO:00486991520.019
Zebrafish
microtubule based processGO:00070172100.019
divalent inorganic cation homeostasisGO:00725071360.019
detection of chemical stimulus involved in sensory perception of bitter tasteGO:0001580280.019
mannose metabolic processGO:000601310.019
purine containing compound catabolic processGO:00725234110.019
tissue remodelingGO:0048771160.019
membrane organizationGO:00610242920.019
bone resorptionGO:004545360.019
cardiovascular system developmentGO:00723582620.019
cognitionGO:0050890430.019
regulation of proteolysisGO:00301622930.019
response to nitrogen compoundGO:19016981840.019
cdc42 protein signal transductionGO:003248840.018
regulation of cellular amine metabolic processGO:0033238110.018
segmentationGO:003528240.018
regulation of cell activationGO:00508651250.018
prostate gland developmentGO:003085030.018
cellular response to extracellular stimulusGO:0031668720.018
multicellular organismal signalingGO:0035637340.018
peptidyl lysine modificationGO:00182051440.018
negative regulation of locomotionGO:00400131180.018
positive regulation of hydrolase activityGO:00513453310.017
secretion by cellGO:00329402260.017
cellular response to endogenous stimulusGO:00714953360.017
response to oxygen levelsGO:00704821000.017
response to reactive oxygen speciesGO:0000302610.017
antigen processing and presentation of exogenous antigenGO:001988440.017
response to abiotic stimulusGO:00096283360.017
mononuclear cell proliferationGO:0032943710.017
hemopoiesisGO:00300971800.017
response to thyroid hormoneGO:009706690.017
negative regulation of catabolic processGO:00098951040.017
erk1 and erk2 cascadeGO:00703711040.017
autophagyGO:0006914880.017
anatomical structure formation involved in morphogenesisGO:00486462840.017
regulation of gtp catabolic processGO:00331241800.017
establishment of protein localization to organelleGO:00725941720.017
regulation of natural killer cell mediated cytotoxicityGO:0042269160.016
hematopoietic or lymphoid organ developmentGO:00485341860.016
blastoderm segmentationGO:000735020.016
negative regulation of protein processingGO:00109551420.016
nucleotide catabolic processGO:00091664080.016
apoptotic signaling pathwayGO:00971902680.016
positive regulation of cell differentiationGO:00455972110.016
regulation of protein import into nucleusGO:0042306780.016
negative regulation of cellular amine metabolic processGO:003323930.016
organelle assemblyGO:00709251760.016
decidualizationGO:004669740.016
positive regulation of gtp catabolic processGO:00331261660.016
musculoskeletal movementGO:0050881170.016
response to oxidative stressGO:00069791210.016
oxidation reduction processGO:00551143960.016
maintenance of location in cellGO:0051651620.016
regulation of cell killingGO:0031341220.015
mapk cascadeGO:00001652880.015
ras protein signal transductionGO:0007265730.015
circulatory system processGO:00030131130.015
leukocyte proliferationGO:0070661740.015
positive regulation of tolerance inductionGO:000264520.015
neurogenesisGO:00220081690.015
Zebrafish
positive regulation of rho gtpase activityGO:0032321560.015
ribonucleotide catabolic processGO:00092614050.015
generation of precursor metabolites and energyGO:0006091680.015
negative regulation of cellular catabolic processGO:0031330830.015
positive regulation of purine nucleotide catabolic processGO:00331231850.014
regulation of microtubule based processGO:0032886740.014
negative regulation of cell proliferationGO:00082852280.014
negative regulation of endopeptidase activityGO:0010951840.014
vasculature developmentGO:00019441810.014
alcohol metabolic processGO:00060661140.014
reactive oxygen species biosynthetic processGO:190340940.014
cellular calcium ion homeostasisGO:00068741170.013
regulation of lymphocyte activationGO:00512491030.013
cell adhesionGO:00071553250.013
regulation of protein processingGO:00706131500.013
cellular protein catabolic processGO:00442572610.013
peptide hormone processingGO:001648690.013
rhythmic behaviorGO:000762220.013
calcium independent cell matrix adhesionGO:000716110.013
regulation of lymphocyte mediated immunityGO:0002706330.013
immune system developmentGO:00025201950.013
muscle system processGO:0003012810.013
negative regulation of transferase activityGO:00513481240.013
positive regulation of cell proliferationGO:00082843010.013
Mouse
cellular response to reactive oxygen speciesGO:0034614500.013
negative regulation of protein maturationGO:19033181420.013
guanosine containing compound metabolic processGO:19010682440.012
positive regulation of secretionGO:00510471160.012
i kappab kinase nf kappab signalingGO:00072491660.012
sensory perceptionGO:00076001030.012
secretionGO:00469032540.012
monovalent inorganic cation homeostasisGO:0055067370.012
response to organic cyclic compoundGO:00140702040.012
camera type eye developmentGO:0043010250.012
protein import into nucleusGO:00066061040.012
necrotic cell deathGO:0070265210.012
negative regulation of apoptotic processGO:00430663160.012
regenerationGO:003109940.012
regulation of immune effector processGO:0002697910.012
positive regulation of leukocyte differentiationGO:1902107370.012
tube developmentGO:00352951250.012
detection of biotic stimulusGO:0009595210.012
regulation of dna replicationGO:0006275680.012
protein localization to nucleusGO:00345041360.012
negative regulation of intracellular signal transductionGO:19025321830.012
detection of chemical stimulus involved in sensory perceptionGO:0050907330.012
single organism behaviorGO:0044708280.012
regulation of cytokine productionGO:00018172320.012
respiratory gaseous exchangeGO:000758530.012
regulation of kinase activityGO:00435493140.011
skeletal system morphogenesisGO:0048705240.011
cellular macromolecular complex assemblyGO:00346223240.011
regulation of gtpase activityGO:00430871800.011
regulation of ras gtpase activityGO:00323181280.011
positive regulation of t cell tolerance inductionGO:000266620.011
lymphocyte mediated immunityGO:0002449480.011
negative regulation of protein catabolic processGO:0042177590.011
protein stabilizationGO:0050821640.011
single organism cellular localizationGO:19025803320.011
phosphatidylinositol metabolic processGO:0046488530.011
monovalent inorganic cation transportGO:00156721280.011
regulation of oxidative stress induced cell deathGO:1903201240.011
multicellular organismal movementGO:0050879170.011
regulation of response to oxidative stressGO:1902882260.011
detection of stimulusGO:0051606850.011
sensory perception of painGO:001923340.011
negative regulation of t cell activationGO:0050868180.011
positive regulation of protein transportGO:00512221350.011
ubiquitin dependent protein catabolic processGO:00065112060.011
regulation of protein localization to nucleusGO:1900180850.011
hair cell differentiationGO:003531520.011
oligosaccharide metabolic processGO:0009311130.011
regulation of neuron apoptotic processGO:0043523350.011
sensory organ developmentGO:0007423520.011
regulation of anatomical structure morphogenesisGO:00226032860.011
lymphocyte proliferationGO:0046651700.010
long term memoryGO:000761620.010
negative regulation of cell migrationGO:00303361020.010
purine ribonucleoside metabolic processGO:00461284370.010
regulation of tolerance inductionGO:000264340.010
neuron differentiationGO:00301821380.010
Zebrafish
regulation of t cell activationGO:0050863770.010
skeletal muscle contractionGO:0003009160.010
regulation of collagen catabolic processGO:001071030.010
regulation of actin filament based processGO:00329701410.010
regulation of immune responseGO:00507762010.010
response to peptide hormoneGO:0043434610.010
tissue regenerationGO:004224630.010

GRN disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
inherited metabolic disorderDOID:6552421.000
lysosomal storage diseaseDOID:3211471.000
disease of metabolismDOID:00146672951.000
lipid storage diseaseDOID:9455280.998
nervous system diseaseDOID:8634310.978
central nervous system diseaseDOID:3311860.978
neuronal ceroid lipofuscinosisDOID:14503110.856
brain diseaseDOID:936730.490
cerebral degenerationDOID:1443160.213
leukodystrophyDOID:1057980.182
sphingolipidosisDOID:1927140.165
acquired metabolic diseaseDOID:0060158580.083
neurodegenerative diseaseDOID:12891020.081
immune system diseaseDOID:29141550.046
mucopolysaccharidosisDOID:12798110.045
carbohydrate metabolic disorderDOID:2978550.038
glycogen metabolism disorderDOID:0050728100.038
glycogen storage diseaseDOID:2747100.038
sensory system diseaseDOID:00501552030.014
eye diseaseDOID:56141490.014
eye and adnexa diseaseDOID:14921500.014
musculoskeletal system diseaseDOID:172230.011
disease of mental healthDOID:150700.011
cognitive disorderDOID:1561290.011