Homo sapiens

0 known processes

TCHH

trichohyalin

(Aliases: MGC157889,MGC157890,THL,TRHY,THH)

TCHH biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular amino acid metabolic processGO:00065201160.075
regulation of cellular component movementGO:00512703340.067
hair follicle morphogenesisGO:003106920.066
regulation of cellular amino acid metabolic processGO:000652160.063
system processGO:00030083490.062
keratinizationGO:003142420.062
post embryonic developmentGO:000979120.061
cellular amine metabolic processGO:0044106410.058
ribonucleoside catabolic processGO:00424544060.057
regulation of locomotionGO:00400123290.054
positive regulation of cellular amine metabolic processGO:003324070.054
regulation of cellular ketone metabolic processGO:0010565500.051
purine ribonucleoside triphosphate metabolic processGO:00092054110.050
defense responseGO:00069523150.049
positive regulation of hydrolase activityGO:00513453310.049
nucleotide catabolic processGO:00091664080.048
amine metabolic processGO:0009308440.047
regulation of cell migrationGO:00303342890.047
actin filament based processGO:00300292240.047
epidermis morphogenesisGO:004873030.047
regulation of cell motilityGO:20001452990.047
positive regulation of transportGO:00510503360.047
cellular response to endogenous stimulusGO:00714953360.046
cellular ketone metabolic processGO:0042180800.046
ribonucleoside triphosphate catabolic processGO:00092033910.046
negative regulation of cell deathGO:00605483450.045
response to lipidGO:00339932060.045
ribonucleotide catabolic processGO:00092614050.045
regulation of cellular amine metabolic processGO:0033238110.045
purine ribonucleoside triphosphate catabolic processGO:00092073910.044
negative regulation of multicellular organismal processGO:00512413170.044
nucleoside triphosphate metabolic processGO:00091414220.043
purine nucleoside triphosphate metabolic processGO:00091444120.043
organophosphate catabolic processGO:00464344300.042
response to oxygen containing compoundGO:19017003690.042
purine ribonucleotide catabolic processGO:00091544040.042
nucleoside catabolic processGO:00091644080.042
negative regulation of programmed cell deathGO:00430693210.041
cellular component morphogenesisGO:00329893140.041
embryonic forelimb morphogenesisGO:003511540.041
nucleoside phosphate catabolic processGO:19012924120.041
purine ribonucleoside metabolic processGO:00461284370.041
positive regulation of cellular amino acid metabolic processGO:004576430.041
secretion by cellGO:00329402260.040
regulation of cell differentiationGO:00455953930.040
glycosyl compound catabolic processGO:19016584130.040
purine nucleotide catabolic processGO:00061954050.040
transmembrane transportGO:00550853990.039
cytoplasmic transportGO:00164823790.039
purine containing compound catabolic processGO:00725234110.039
response to organic cyclic compoundGO:00140702040.038
ribonucleoside triphosphate metabolic processGO:00091994120.038
lipid metabolic processGO:00066293810.038
cardiac muscle cell contractionGO:008600340.037
purine ribonucleoside catabolic processGO:00461303980.037
purine nucleoside triphosphate catabolic processGO:00091463920.037
purine nucleoside catabolic processGO:00061523980.036
vesicle mediated transportGO:00161923710.036
regulation of secretion by cellGO:19035301770.035
negative regulation of apoptotic processGO:00430663160.035
positive regulation of cellular component organizationGO:00511303760.035
positive regulation of cell proliferationGO:00082843010.035
small gtpase mediated signal transductionGO:0007264780.035
negative regulation of cellular protein metabolic processGO:00322693530.035
ras protein signal transductionGO:0007265730.035
cation transportGO:00068123310.034
organ morphogenesisGO:00098871470.034
regulation of proteolysisGO:00301622930.034
regulation of secretionGO:00510461940.034
protein maturationGO:00516042330.033
nucleoside triphosphate catabolic processGO:00091433940.033
epithelium developmentGO:00604292270.033
negative regulation of cell proliferationGO:00082852280.033
single organism cellular localizationGO:19025803320.033
guanosine containing compound metabolic processGO:19010682440.032
positive regulation of phosphorylationGO:00423273940.032
female gamete generationGO:000729220.032
forelimb morphogenesisGO:003513640.032
locomotory behaviorGO:000762610.032
negative regulation of developmental processGO:00510932470.032
biological adhesionGO:00226103310.032
response to external biotic stimulusGO:00432072610.032
regulation of transferase activityGO:00513383550.032
regulation of protein localizationGO:00328802960.032
anion transportGO:00068201610.032
negative regulation of protein metabolic processGO:00512483910.031
cellular response to oxygen containing compoundGO:19017012760.031
enzyme linked receptor protein signaling pathwayGO:00071673030.031
actin mediated cell contractionGO:0070252120.031
multicellular organismal agingGO:001025930.031
small molecule biosynthetic processGO:00442831570.030
cellular macromolecule catabolic processGO:00442653800.030
hair cycleGO:0042633280.030
positive regulation of immune system processGO:00026842830.030
innate immune responseGO:00450871780.030
response to hormoneGO:00097251750.030
positive regulation of nucleotide metabolic processGO:00459812300.030
cell adhesionGO:00071553250.029
cell morphogenesisGO:00009022960.029
epithelial cell differentiationGO:00308551410.029
regenerationGO:003109940.029
regulation of nucleotide metabolic processGO:00061402690.029
chemical homeostasisGO:00488783060.029
cytokine productionGO:00018162470.029
neurological system processGO:00508771630.029
g protein coupled receptor signaling pathwayGO:00071862070.029
segmentationGO:003528240.029
nervous system developmentGO:00073992930.028
cell developmentGO:00484683280.028
membrane organizationGO:00610242920.028
regulation of purine nucleotide metabolic processGO:19005422640.028
response to cytokineGO:00340972320.028
positive regulation of catabolic processGO:00098963100.028
regulation of cell cycleGO:00517263930.028
cell projection organizationGO:00300302520.028
determination of adult lifespanGO:000834020.028
anatomical structure formation involved in morphogenesisGO:00486462840.028
regulation of anatomical structure morphogenesisGO:00226032860.028
immune responseGO:00069553070.027
positive regulation of programmed cell deathGO:00430682490.027
ion transmembrane transportGO:00342203380.027
oogenesisGO:004847720.027
single organism membrane organizationGO:00448022680.027
guanosine containing compound catabolic processGO:19010692390.027
positive regulation of apoptotic processGO:00430652460.027
inorganic ion transmembrane transportGO:00986602310.027
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.027
positive regulation of cellular catabolic processGO:00313312840.026
protein catabolic processGO:00301633250.026
positive regulation of cell deathGO:00109422630.026
cellular lipid metabolic processGO:00442553030.026
actin filament based movementGO:0030048170.026
response to other organismGO:00517072610.026
gtp metabolic processGO:00460392390.026
regulation of nucleoside metabolic processGO:00091182090.026
circulatory system developmentGO:00723592620.026
regulation of cell adhesionGO:00301551660.026
protein processingGO:00164852260.026
secretionGO:00469032540.025
response to nitrogen compoundGO:19016981840.025
cardiovascular system developmentGO:00723582620.025
negative regulation of phosphorus metabolic processGO:00105632670.025
lipid biosynthetic processGO:00086101770.025
negative regulation of catalytic activityGO:00430863350.025
regulation of actin filament based processGO:00329701410.025
regulation of ion transportGO:00432691890.025
regulation of purine nucleotide catabolic processGO:00331212050.025
endomembrane system organizationGO:00102561960.025
response to biotic stimulusGO:00096072760.025
regulation of sequence specific dna binding transcription factor activityGO:00510902110.025
regulation of cytokine productionGO:00018172320.025
tissue migrationGO:00901301190.025
positive regulation of cell differentiationGO:00455972110.024
blood vessel developmentGO:00015681720.024
regulation of establishment of protein localizationGO:00702012420.024
positive regulation of developmental processGO:00510943140.024
organ formationGO:004864530.024
epithelial cell proliferationGO:00506731280.024
regulation of nucleotide catabolic processGO:00308112050.024
cell cell signalingGO:00072671550.024
positive regulation of purine nucleotide metabolic processGO:19005442270.024
response to organonitrogen compoundGO:00102431560.024
protein modification by small protein conjugationGO:00324463420.024
skin developmentGO:0043588760.024
rho protein signal transductionGO:0007266260.024
positive regulation of locomotionGO:00400171860.024
mitotic cell cycleGO:00002783260.024
actin cytoskeleton organizationGO:00300362070.023
negative regulation of locomotionGO:00400131180.023
response to abiotic stimulusGO:00096283360.023
gtp catabolic processGO:00061842370.023
epithelium migrationGO:00901321190.023
ameboidal type cell migrationGO:00016671350.023
regulation of cell cycle processGO:00105642660.023
apoptotic signaling pathwayGO:00971902680.023
regulation of cellular component biogenesisGO:00440872810.023
oxidation reduction processGO:00551143960.023
cell activationGO:00017752130.022
negative regulation of cell differentiationGO:00455961710.022
regulation of endopeptidase activityGO:00525481700.022
epithelial cell migrationGO:00106311190.022
androgen biosynthetic processGO:000670230.022
regulation of protein kinase activityGO:00458592890.022
positive regulation of cell motilityGO:20001471770.022
cellular response to cytokine stimulusGO:00713451810.022
regulation of kinase activityGO:00435493140.022
maintenance of locationGO:00512351120.022
regulation of response to external stimulusGO:00321012220.022
viral life cycleGO:00190581320.022
cellular protein catabolic processGO:00442572610.022
protein ubiquitinationGO:00165673140.021
protein localization to organelleGO:00333652800.021
positive regulation of protein phosphorylationGO:00019343130.021
negative regulation of cell motilityGO:20001461040.021
neuromuscular junction developmentGO:000752830.021
negative regulation of cellular amine metabolic processGO:003323930.021
intracellular protein transportGO:00068862700.021
positive regulation of nucleoside metabolic processGO:00459791860.021
cellular response to histamineGO:007142030.021
cellular response to organic cyclic compoundGO:00714071270.021
negative regulation of phosphate metabolic processGO:00459362670.021
regulation of gtp catabolic processGO:00331241800.021
positive regulation of purine nucleotide catabolic processGO:00331231850.021
interspecies interaction between organismsGO:00444191560.021
positive regulation of cell migrationGO:00303351720.021
cellular macromolecular complex assemblyGO:00346223240.020
positive regulation of aldosterone metabolic processGO:003234620.020
vasculature developmentGO:00019441810.020
regulation of protein transportGO:00512232130.020
reactive oxygen species biosynthetic processGO:190340940.020
cellular response to dna damage stimulusGO:00069743790.020
wnt signaling pathwayGO:00160551560.020
negative regulation of cellular amino acid metabolic processGO:004576320.020
cellular response to growth factor stimulusGO:00713631970.020
positive regulation of cytokine productionGO:00018191670.020
establishment of protein localization to membraneGO:00901501210.020
organonitrogen compound biosynthetic processGO:19015662000.020
cell growthGO:00160491600.020
nitrogen compound transportGO:00717051910.019
mitotic cell cycle processGO:19030472860.019
regulation of intracellular transportGO:00323861950.019
negative regulation of cellular component movementGO:00512711060.019
motor neuron axon guidanceGO:000804520.019
protein localization to membraneGO:00726571600.019
response to growth factorGO:00708482050.019
regulation of peptidase activityGO:00525471800.019
morphogenesis of embryonic epitheliumGO:001633140.019
anterior posterior axis specificationGO:000994820.019
inorganic cation transmembrane transportGO:00986621940.019
hindbrain developmentGO:003090230.019
positive regulation of nucleotide catabolic processGO:00308131850.019
negative regulation of cell cycleGO:00457861930.019
cellular chemical homeostasisGO:00550821800.019
mapk cascadeGO:00001652880.019
pulmonary vein morphogenesisGO:006057710.019
posttranscriptional regulation of gene expressionGO:00106082130.019
protein localization to plasma membraneGO:0072659930.019
sex determinationGO:000753030.018
positive regulation of gtpase activityGO:00435471660.018
regulation of gtpase activityGO:00430871800.018
glial cell migrationGO:000834740.018
positive regulation of gtp catabolic processGO:00331261660.018
protein oligomerizationGO:00512591730.018
nerve developmentGO:002167540.018
signal transduction by phosphorylationGO:00230142970.018
organelle assemblyGO:00709251760.018
regulation of male gonad developmentGO:200001840.018
carbohydrate derivative biosynthetic processGO:19011372070.018
rhythmic behaviorGO:000762220.018
muscle system processGO:0003012810.018
negative regulation of cellular component organizationGO:00511292350.018
positive regulation of transferase activityGO:00513472270.018
positive regulation of cellular component movementGO:00512721810.018
proteolysis involved in cellular protein catabolic processGO:00516032440.018
regulation of neural precursor cell proliferationGO:200017740.018
reactive nitrogen species metabolic processGO:200105730.018
regulation of multi organism processGO:00439001570.017
negative regulation of hydrolase activityGO:00513461820.017
ion homeostasisGO:00508012300.017
gamma aminobutyric acid signaling pathwayGO:000721430.017
limb bud formationGO:006017410.017
positive regulation of proteolysisGO:00458621420.017
response to fungusGO:000962040.017
organic hydroxy compound metabolic processGO:19016151470.017
tissue regenerationGO:004224630.017
plasma membrane organizationGO:00070091150.017
response to woundingGO:00096111680.017
peripheral nervous system developmentGO:000742220.017
cell fate determinationGO:000170930.017
positive regulation of mapk cascadeGO:00434101900.017
ossificationGO:00015031210.017
regulation of hormone levelsGO:00108171250.017
cation transmembrane transportGO:00986552380.017
cellular response to lipidGO:00713961270.017
regulation of growthGO:00400081650.017
positive regulation of protein transportGO:00512221350.017
hematopoietic or lymphoid organ developmentGO:00485341860.017
multi organism cellular processGO:00447641560.017
blastoderm segmentationGO:000735020.017
positive regulation of organelle organizationGO:00106381950.017
sensory perception of painGO:001923340.017
adult locomotory behaviorGO:000834410.016
inner ear morphogenesisGO:004247240.016
regulation of mapk cascadeGO:00434082620.016
positive regulation of secretion by cellGO:19035321080.016
cellular homeostasisGO:00197251960.016
circadian behaviorGO:004851220.016
divalent inorganic cation homeostasisGO:00725071360.016
cardiac muscle contractionGO:0060048340.016
negative regulation of protein modification processGO:00314002000.016
regulation of ras gtpase activityGO:00323181280.016
endodermal cell fate commitmentGO:000171140.016
regulation of small gtpase mediated signal transductionGO:00510561560.016
immune system developmentGO:00025201950.016
muscle contractionGO:0006936730.016
chromatin organizationGO:00063253510.016
positive regulation of aldosterone biosynthetic processGO:003234920.016
reactive oxygen species metabolic processGO:0072593750.016
positive regulation of immune responseGO:00507781590.016
single organism carbohydrate metabolic processGO:00447231930.016
monovalent inorganic cation transportGO:00156721280.016
positive regulation of acrosome reactionGO:200034440.016
alcohol metabolic processGO:00060661140.016
regulation of cellular response to stressGO:00801352440.016
neurogenesisGO:00220081690.016
monocarboxylic acid metabolic processGO:00327871850.016
cellular response to nitrogen compoundGO:19016991440.016
regulation of cysteine type endopeptidase activityGO:20001161270.016
negative regulation of cell migrationGO:00303361020.016
regulation of ras protein signal transductionGO:00465781550.016
organophosphate biosynthetic processGO:00904071630.016
growthGO:00400072020.016
regulation of apoptotic signaling pathwayGO:20012331750.016
regulation of reactive oxygen species biosynthetic processGO:190342630.016
pituitary gland developmentGO:002198320.016
photoreceptor cell differentiationGO:004653020.016
regulation of protein maturationGO:19033171500.016
multicellular organismal homeostasisGO:0048871670.016
regulation of symbiosis encompassing mutualism through parasitismGO:00439031090.016
oocyte developmentGO:004859910.015
oocyte differentiationGO:000999420.015
symbiosis encompassing mutualism through parasitismGO:00444031560.015
canonical wnt signaling pathway involved in cardiac muscle cell fate commitmentGO:006131730.015
positive regulation of secretionGO:00510471160.015
regulation of protein catabolic processGO:00421761550.015
regulation of membrane potentialGO:0042391950.015
regulation of immune responseGO:00507762010.015
cranial nerve developmentGO:002154540.015
metal ion transportGO:00300012720.015
sodium ion transmembrane transportGO:0035725590.015
embryonic epithelial tube formationGO:000183840.015
immune effector processGO:00022521590.015
sequestering of calcium ionGO:0051208170.015
cellular response to organonitrogen compoundGO:00714171240.015
keratinocyte differentiationGO:0030216360.015
golgi to plasma membrane cftr protein transportGO:004300010.015
viral processGO:00160321460.015
regulation of homeostatic processGO:00328441210.015
spermatid differentiationGO:004851540.015
central nervous system developmentGO:00074171230.015
positive regulation of ras gtpase activityGO:00323201170.015
cell proliferation in forebrainGO:002184610.015
regulation of cytoskeleton organizationGO:00514931770.015
limbic system developmentGO:002176130.015
carbohydrate metabolic processGO:00059752070.015
anterior posterior axis specification embryoGO:000859520.015
negative regulation of synaptic transmissionGO:005080520.015
cellular cation homeostasisGO:00300031630.015
nucleocytoplasmic transportGO:00069131760.015
rna processingGO:00063962550.015
regulation of synaptic plasticityGO:004816730.015
cation homeostasisGO:00550801890.015
negative regulation of transportGO:00510511760.015
tube developmentGO:00352951250.015
memoryGO:000761330.015
regulation of cell growthGO:00015581350.015
cellular ion homeostasisGO:00068731680.015
single organism cell adhesionGO:00986021790.014
regulation of protein complex assemblyGO:00432541470.014
tripartite regional subdivisionGO:000735120.014
carboxylic acid biosynthetic processGO:0046394970.014
purine ribonucleoside monophosphate metabolic processGO:00091671860.014
positive regulation of kinase activityGO:00336742040.014
oxidative stress induced premature senescenceGO:009040330.014
salivary gland morphogenesisGO:000743540.014
blood circulationGO:00080151130.014
head developmentGO:00603221080.014
tissue morphogenesisGO:0048729960.014
intermediate filament cytoskeleton organizationGO:0045104170.014
sensory perceptionGO:00076001030.014
dephosphorylationGO:00163112090.014
heart formationGO:006091420.014
positive regulation of protein kinase activityGO:00458601900.014
serotonin transportGO:000683730.014
negative regulation of growthGO:0045926970.014
regulation of meiotic cell cycleGO:005144540.014
negative regulation of protein maturationGO:19033181420.014
blood vessel morphogenesisGO:00485141620.014
sequestering of metal ionGO:0051238240.014
taxisGO:00423301570.014
divalent inorganic cation transportGO:00725111580.014
protein targetingGO:00066051870.014
divalent metal ion transportGO:00708381520.014
establishment of protein localization to organelleGO:00725941720.014
intermediate filament based processGO:0045103170.014
metencephalon developmentGO:002203720.014
glycine importGO:003623310.014
regulation of cell developmentGO:00602841610.014
regulation of mitotic cell cycleGO:00073461890.014
negative regulation of phosphorylationGO:00423261740.014
regulation of epithelial cell proliferationGO:00506781130.014
negative regulation of transmission of nerve impulseGO:005197010.014
compound eye developmentGO:004874910.014
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.014
regulation of bindingGO:00510981110.014
regulation of cytoplasmic transportGO:19036491490.014
modification dependent macromolecule catabolic processGO:00436322120.014
chemotaxisGO:00069351570.014
negative regulation of insulin secretion involved in cellular response to glucose stimulusGO:006117910.014
negative regulation of catabolic processGO:00098951040.014
single organismal cell cell adhesionGO:00163371480.013
regulation of protein processingGO:00706131500.013
organic acid biosynthetic processGO:0016053970.013
protein secretionGO:0009306980.013
wound healingGO:00420601150.013
mitochondrion organizationGO:00070051560.013
positive regulation of peptidase activityGO:0010952880.013
cellular response to hormone stimulusGO:00328701250.013
hormone metabolic processGO:0042445610.013
release of cytoplasmic sequestered nf kappabGO:000858840.013
atp metabolic processGO:00460341760.013
ribonucleoside monophosphate metabolic processGO:00091611870.013
hemopoiesisGO:00300971800.013
nuclear transportGO:00511691790.013
embryonic hindlimb morphogenesisGO:003511620.013
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.013
ubiquitin dependent protein catabolic processGO:00065112060.013
regulation of i kappab kinase nf kappab signalingGO:00431221620.013
foramen ovale closureGO:003592210.013
microtubule based processGO:00070172100.013
leukocyte activationGO:00453211640.013
cell divisionGO:00513011680.013
cellular protein complex assemblyGO:00436231880.013
canonical wnt signaling pathwayGO:00600701160.013
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.013
positive regulation of cortisol biosynthetic processGO:200006610.013
regulation of cytokine secretionGO:0050707570.013
purine nucleoside monophosphate metabolic processGO:00091261860.013
regulation of actin cytoskeleton organizationGO:00329561160.013
i kappab kinase nf kappab signalingGO:00072491660.013
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiationGO:000325730.013
activation of immune responseGO:00022531140.013
brain developmentGO:0007420970.013
response to virusGO:00096151260.013
epidermis developmentGO:0008544590.013
forebrain generation of neuronsGO:002187230.013
regulation of response to woundingGO:19030341010.013
embryonic morphogenesisGO:0048598850.013
cellular divalent inorganic cation homeostasisGO:00725031280.013
regulation of wnt signaling pathwayGO:00301111230.013
outflow tract septum morphogenesisGO:000314840.013
regulation of leukocyte activationGO:00026941150.013
forebrain regionalizationGO:002187130.013
spermatid developmentGO:000728640.013
positive regulation of cell cycleGO:00457871400.013
protein homooligomerizationGO:00512601000.013
peptidyl tyrosine phosphorylationGO:00181081700.013
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.013
regulation of protein stabilityGO:0031647870.013
cerebellum developmentGO:002154920.013
thymus developmentGO:004853830.013
regulation of cell morphogenesisGO:00226041530.013
positive regulation of epithelial cell proliferation involved in wound healingGO:006005430.013
chromatin modificationGO:00165682980.013
metal ion homeostasisGO:00550651690.013
cd8 positive alpha beta t cell activationGO:003603730.013
protein acylationGO:00435431380.013
angiogenesisGO:00015251470.013
defense response to fungusGO:005083240.013
organic anion transportGO:00157111030.012
response to bacteriumGO:00096171440.012
positive regulation of cysteine type endopeptidase activityGO:2001056790.012
startle responseGO:000196430.012
cell cycle phase transitionGO:00447701730.012
positive regulation of synaptic transmissionGO:005080640.012
regulation of heart growthGO:006042040.012
negative regulation of protein processingGO:00109551420.012
cellular response to ammonium ionGO:007124240.012
nucleoside monophosphate metabolic processGO:00091231910.012
anion transmembrane transportGO:0098656760.012
negative regulation of proteolysisGO:00458611320.012
establishment of protein localization to plasma membraneGO:0090002680.012
regulation of protein secretionGO:0050708860.012
anatomical structure homeostasisGO:00602491000.012
negative regulation of intracellular signal transductionGO:19025321830.012
regulation of protein modification by small protein conjugation or removalGO:19033201070.012

TCHH disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
sensory system diseaseDOID:00501552030.054
nervous system diseaseDOID:8634310.054
eye and adnexa diseaseDOID:14921500.039
eye diseaseDOID:56141490.037
musculoskeletal system diseaseDOID:172230.035
disease of metabolismDOID:00146672950.029
inherited metabolic disorderDOID:6552420.025
retinal diseaseDOID:56791180.024
bone diseaseDOID:0080001880.023
connective tissue diseaseDOID:651090.023
central nervous system diseaseDOID:3311860.021
disease of cellular proliferationDOID:145661740.019
cancerDOID:1621670.019
organ system cancerDOID:00506861640.018
immune system diseaseDOID:29141550.014
neurodegenerative diseaseDOID:12891020.014
retinal degenerationDOID:8466890.013