Homo sapiens

151 known processes

CASP8

caspase 8, apoptosis-related cysteine peptidase

(Aliases: FLJ17672,Casp-8,CAP4,FLICE,MGC78473,MCH5,ALPS2B,MACH)

CASP8 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
programmed necrotic cell deathGO:0097300181.000
Mouse
trail activated apoptotic signaling pathwayGO:003646241.000
cellular response to increased oxygen levelsGO:003629541.000
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280691.000
Mouse
skeletal muscle satellite cell proliferationGO:001484111.000
positive regulation of extrinsic apoptotic signaling pathwayGO:2001238261.000
Mouse
regulation of peptidase activityGO:00525471801.000
positive regulation of apoptotic signaling pathwayGO:2001235701.000
Mouse
positive regulation of release of cytochrome c from mitochondriaGO:0090200181.000
release of cytoplasmic sequestered nf kappabGO:000858841.000
lymphocyte apoptotic processGO:0070227201.000
Mouse
t cell apoptotic processGO:0070231121.000
Mouse
regulation of extrinsic apoptotic signaling pathwayGO:2001236851.000
Mouse
positive regulation of i kappab kinase nf kappab signalingGO:00431231321.000
zymogen activationGO:0031638701.000
positive regulation of myeloid leukocyte differentiationGO:0002763241.000
regulation of endopeptidase activityGO:00525481701.000
protein processingGO:00164852261.000
extrinsic apoptotic signaling pathwayGO:00971911191.000
positive regulation of apoptotic processGO:00430652461.000
Human Mouse
positive regulation of cell deathGO:00109422631.000
Human Mouse
i kappab kinase nf kappab signalingGO:00072491661.000
response to cobalt ionGO:003202511.000
Rat
extrinsic apoptotic signaling pathway via death domain receptorsGO:0008625421.000
regulation of apoptotic signaling pathwayGO:20012331751.000
Mouse
regulation of myeloid cell differentiationGO:0045637811.000
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811161.000
Mouse
cell type specific apoptotic processGO:00972851251.000
Mouse
activation induced cell death of t cellsGO:000692421.000
cellular response to hyperoxiaGO:007145541.000
negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:1902042151.000
release of cytochrome c from mitochondriaGO:0001836351.000
regulation of proteolysisGO:00301622931.000
positive regulation of cysteine type endopeptidase activityGO:2001056791.000
negative regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043154461.000
apoptotic mitochondrial changesGO:0008637571.000
necroptotic processGO:0070266161.000
Mouse
necrotic cell deathGO:0070265211.000
Mouse
regulation of i kappab kinase nf kappab signalingGO:00431221621.000
positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204331.000
leukocyte apoptotic processGO:0071887311.000
Mouse
regulation of cysteine type endopeptidase activityGO:20001161271.000
positive regulation of programmed cell deathGO:00430682490.999
Human Mouse
apoptotic signaling pathwayGO:00971902680.999
regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:1902041240.999
regulation of release of cytochrome c from mitochondriaGO:0090199290.999
activation of cysteine type endopeptidase activity involved in apoptotic processGO:0006919490.999
Mouse
positive regulation of proteolysisGO:00458621420.999
positive regulation of nik nf kappab signalingGO:1901224100.999
activation of cysteine type endopeptidase activityGO:0097202570.999
positive regulation of peptidase activityGO:0010952880.999
regulation of necroptotic processGO:006054470.999
Mouse
intrinsic apoptotic signaling pathwayGO:00971931270.998
Human
positive regulation of cellular amine metabolic processGO:003324070.998
positive regulation of activated t cell proliferationGO:0042104110.998
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressGO:0070059120.997
positive regulation of endopeptidase activityGO:0010950840.997
leukocyte differentiationGO:0002521980.997
cellular response to mechanical stimulusGO:0071260390.997
response to endoplasmic reticulum stressGO:0034976490.997
cellular response to external stimulusGO:00714961110.996
positive regulation of hydrolase activityGO:00513453310.996
regulation of leukocyte differentiationGO:1902105610.996
necroptotic signaling pathwayGO:009752760.996
macrophage differentiationGO:0030225110.996
cellular response to tumor necrosis factorGO:0071356630.996
myeloid leukocyte differentiationGO:0002573600.996
immune system developmentGO:00025201950.996
positive regulation of protein serine threonine kinase activityGO:00719021190.995
positive regulation of nf kappab import into nucleusGO:0042346130.995
positive regulation of endothelial cell apoptotic processGO:200035380.995
protein maturationGO:00516042330.994
thymus developmentGO:004853830.994
negative regulation of t cell apoptotic processGO:007023340.994
negative regulation of cell deathGO:00605483450.992
Human Mouse
positive regulation of nf kappab transcription factor activityGO:0051092810.992
negative regulation of proteolysisGO:00458611320.992
cytokine mediated signaling pathwayGO:00192211090.992
positive regulation of defense responseGO:0031349870.991
regulation of myeloid leukocyte differentiationGO:0002761390.991
extrinsic apoptotic signaling pathway in absence of ligandGO:0097192220.991
mitotic dna damage checkpointGO:0044773280.990
Human
cellular response to dna damage stimulusGO:00069743790.990
Human
negative regulation of extrinsic apoptotic signaling pathwayGO:2001237520.989
response to tumor necrosis factorGO:0034612760.989
regulation of protein processingGO:00706131500.989
regulation of macrophage differentiationGO:004564990.988
regulation of cellular response to stressGO:00801352440.987
Human
neuron projection regenerationGO:003110210.986
cellular protein catabolic processGO:00442572610.986
regulation of cellular extravasationGO:000269180.985
regulation of sequence specific dna binding transcription factor activityGO:00510902110.982
negative regulation of g1 s transition of mitotic cell cycleGO:2000134290.981
Human
regulation of lymphocyte apoptotic processGO:0070228150.981
Mouse
response to mechanical stimulusGO:0009612510.981
regulation of cellular amino acid metabolic processGO:000652160.980
execution phase of apoptosisGO:0097194320.976
peptidyl serine autophosphorylationGO:003628920.976
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630500.976
Human
response to hyperoxiaGO:005509340.975
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrestGO:000697790.974
Human
proteolysis involved in cellular protein catabolic processGO:00516032440.974
signal transduction involved in mitotic cell cycle checkpointGO:0072413130.972
Human
regulation of cell cycle g1 s phase transitionGO:1902806420.972
Human
positive regulation of leukocyte differentiationGO:1902107370.972
positive regulation of bone resorptionGO:004578020.971
t cell differentiation in thymusGO:003307740.971
regulation of myoblast fusionGO:190173910.968
positive regulation of osteoclast differentiationGO:004567290.966
cellular amino acid metabolic processGO:00065201160.966
response to biotic stimulusGO:00096072760.965
Rat
regulation of lymphocyte activationGO:00512491030.964
protein homooligomerizationGO:00512601000.963
positive regulation of jak stat cascadeGO:0046427350.963
regulation of cell cycle arrestGO:0071156360.962
Human
response to cytokineGO:00340972320.961
regulation of defense responseGO:00313471540.961
negative regulation of peptidase activityGO:0010466910.960
positive regulation of homotypic cell cell adhesionGO:003411240.958
positive regulation of cellular amino acid metabolic processGO:004576430.955
cellular macromolecule catabolic processGO:00442653800.955
regulation of cellular ketone metabolic processGO:0010565500.948
regulation of endothelial cell apoptotic processGO:2000351240.947
developmental programmed cell deathGO:001062330.947
positive regulation of phosphorylationGO:00423273940.947
activated t cell proliferationGO:0050798130.946
negative regulation of defense responseGO:0031348470.946
regulation of adaptive immune responseGO:0002819330.945
cellular ketone metabolic processGO:0042180800.945
protein catabolic processGO:00301633250.944
positive regulation of developmental processGO:00510943140.942
regulation of response to dna damage stimulusGO:2001020940.941
Human
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.940
positive regulation of immune system processGO:00026842830.938
lymphocyte homeostasisGO:000226040.932
positive regulation of protein phosphorylationGO:00019343130.929
endothelial cell apoptotic processGO:0072577260.929
cellular response to abiotic stimulusGO:00712141170.929
signal transduction involved in cell cycle checkpointGO:0072395160.926
Human
signal transduction in response to dna damageGO:0042770570.925
Human
intracellular signal transduction involved in g1 dna damage checkpointGO:1902400100.925
Human
positive regulation of macrophage differentiationGO:004565170.923
spleen developmentGO:004853610.923
dna damage response signal transduction by p53 class mediatorGO:0030330440.923
Human
response to increased oxygen levelsGO:003629640.921
amine metabolic processGO:0009308440.919
positive regulation of tumor necrosis factor superfamily cytokine productionGO:1903557220.918
t cell homeostasisGO:004302930.916
negative regulation of apoptotic signaling pathwayGO:2001234970.915
myeloid cell differentiationGO:00300991170.915
positive regulation of mapk cascadeGO:00434101900.912
positive regulation of myeloid cell differentiationGO:0045639390.911
activation of nf kappab inducing kinase activityGO:000725090.910
g1 dna damage checkpointGO:0044783180.903
Human
positive regulation of t cell migrationGO:2000406130.899
peptidyl tyrosine phosphorylationGO:00181081700.897
negative regulation of endopeptidase activityGO:0010951840.896
negative regulation of programmed cell deathGO:00430693210.896
Human Mouse
response to abiotic stimulusGO:00096283360.893
negative regulation of intracellular signal transductionGO:19025321830.891
regulation of inflammatory responseGO:0050727460.883
negative regulation of protein maturationGO:19033181420.883
negative regulation of protein processingGO:00109551420.882
negative regulation of apoptotic processGO:00430663160.881
Human
defense response to virusGO:0051607710.881
system processGO:00030083490.881
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002460400.880
regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:2001239200.879
negative regulation of lymphocyte apoptotic processGO:007022980.878
response to waterGO:000941520.875
response to uvGO:0009411730.867
Human
mitotic g1 dna damage checkpointGO:0031571170.861
Human
regulation of osteoclast differentiationGO:0045670180.857
regulation of leukocyte apoptotic processGO:2000106250.854
Mouse
striated muscle adaptationGO:001488840.853
negative regulation of cysteine type endopeptidase activityGO:2000117480.852
regulation of g1 s transition of mitotic cell cycleGO:2000045400.852
Human
positive regulation of cell activationGO:0050867810.850
protein oligomerizationGO:00512591730.843
Rat
regulation of necrotic cell deathGO:001093990.835
Mouse
defense responseGO:00069523150.829
regulation of t cell migrationGO:2000404140.828
positive regulation of cell cycle arrestGO:0071158230.824
Human
regulation of cell cycleGO:00517263930.822
Human
positive regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124140.820
cell cycle arrestGO:0007050710.813
Human
negative regulation of cellular protein metabolic processGO:00322693530.812
regulation of immune effector processGO:0002697910.812
mitotic g1 s transition checkpointGO:0044819170.811
Human
regulation of map kinase activityGO:00434051080.804
regenerationGO:003109940.794
regulation of cell differentiationGO:00455953930.791
t cell activationGO:0042110990.779
homeostasis of number of cellsGO:0048872400.766
Human
regulation of transferase activityGO:00513383550.765
neural nucleus developmentGO:0048857470.759
Human
positive regulation of lymphocyte proliferationGO:0050671460.758
positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathwayGO:200126910.752
regulation of protein maturationGO:19033171500.738
positive regulation of intracellular transportGO:00323881040.735
positive regulation of protein kinase activityGO:00458601900.733
regulation of satellite cell proliferationGO:001484210.728
vasculature developmentGO:00019441810.726
Mouse
negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:2001240160.720
cell cycle phase transitionGO:00447701730.719
Human
toll like receptor 2 signaling pathwayGO:003413440.715
melanin metabolic processGO:000658210.712
regulation of syncytium formation by plasma membrane fusionGO:006014220.709
regulation of protein targetingGO:1903533910.709
positive regulation of intrinsic apoptotic signaling pathwayGO:2001244280.708
leukocyte migrationGO:00509001070.707
regulation of cellular amine metabolic processGO:0033238110.707
positive regulation of tyrosine phosphorylation of stat proteinGO:0042531280.704
neuron cellular homeostasisGO:007005030.703
single organism nuclear importGO:19025931040.703
dna damage checkpointGO:0000077680.702
Human
regulation of tyrosine phosphorylation of stat proteinGO:0042509300.701
negative regulation of catalytic activityGO:00430863350.697
cytoplasmic sequestering of nf kappabGO:000725370.688
myoblast fusionGO:000752010.665
cellular amine metabolic processGO:0044106410.663
neuron apoptotic processGO:0051402390.661
adaptive immune responseGO:0002250490.661
negative regulation of cell cycle phase transitionGO:1901988890.659
Human
erk1 and erk2 cascadeGO:00703711040.659
inflammatory cell apoptotic processGO:000692530.658
apoptotic cell clearanceGO:0043277120.657
signal transduction by phosphorylationGO:00230142970.653
positive regulation of map kinase activityGO:0043406800.646
engulfment of apoptotic cellGO:004365220.645
defense response to bacteriumGO:0042742630.633
innate immune responseGO:00450871780.631
negative regulation of i kappab kinase nf kappab signalingGO:0043124320.628
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.612
regulation of peptidyl tyrosine phosphorylationGO:00507301080.606
lymphocyte migrationGO:0072676280.599
regulation of intracellular transportGO:00323861950.598
epithelium developmentGO:00604292270.593
Human Mouse
negative regulation of striated muscle cell differentiationGO:005115480.593
ubiquitin dependent protein catabolic processGO:00065112060.587
positive regulation of lymphocyte mediated immunityGO:0002708230.585
regulation of tumor necrosis factor productionGO:0032680430.582
leukocyte activationGO:00453211640.582
lymphocyte mediated immunityGO:0002449480.580
cellular response to cytokine stimulusGO:00713451810.580
negative regulation of protein metabolic processGO:00512483910.577
positive regulation of immune responseGO:00507781590.576
membrane organizationGO:00610242920.567
positive regulation of protein homooligomerizationGO:003246470.564
cell cycle g1 s phase transitionGO:0044843800.562
Human
establishment of protein localization to organelleGO:00725941720.560
positive regulation of type i interferon mediated signaling pathwayGO:006034040.552
regulation of mitotic cell cycle phase transitionGO:19019901180.549
Human
negative regulation of muscle cell differentiationGO:0051148170.547
response to oxygen containing compoundGO:19017003690.547
Rat
regulation of homeostatic processGO:00328441210.547
regulation of nucleocytoplasmic transportGO:0046822980.538
positive regulation of adaptive immune responseGO:0002821210.538
response to virusGO:00096151260.529
regulation of t cell activationGO:0050863770.528
pigment metabolic processGO:0042440160.526
negative regulation of immune system processGO:00026831360.523
regulation of cell cycle processGO:00105642660.521
Human
positive regulation of innate immune responseGO:0045089790.516
signal transduction by p53 class mediatorGO:0072331720.510
Human
brain developmentGO:0007420970.505
Human
interferon gamma productionGO:0032609390.500
activation of protein kinase activityGO:0032147900.500
response to external biotic stimulusGO:00432072610.489
Rat
regulation of mitotic cell cycleGO:00073461890.486
Human
regulation of mapk cascadeGO:00434082620.481
positive regulation of tyrosine phosphorylation of stat1 proteinGO:004251180.480
regulation of cell killingGO:0031341220.479
jak stat cascadeGO:0007259460.475
regulation of protein transportGO:00512232130.469
negative regulation of transportGO:00510511760.450
transformed cell apoptotic processGO:000692730.446
muscle system processGO:0003012810.446
regulation of activated t cell proliferationGO:0046006120.436
regulation of ion transmembrane transportGO:00347651320.436
cell activationGO:00017752130.435
negative regulation of protein localization to nucleusGO:1900181340.435
positive regulation of cellular component organizationGO:00511303760.420
cellular response to lithium ionGO:007128520.411
regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathwayGO:200126720.408
mitotic cell cycle checkpointGO:0007093680.406
Human
positive regulation of cell differentiationGO:00455972110.403
regulation of jak stat cascadeGO:0046425440.396
regulation of mitochondrion organizationGO:0010821540.391
mitotic cell cycleGO:00002783260.391
Human
response to other organismGO:00517072610.391
Rat
proteasomal protein catabolic processGO:00104981760.389
negative regulation of leukocyte apoptotic processGO:2000107160.387
positive regulation of leukocyte activationGO:0002696800.386
t cell differentiationGO:0030217290.383
cellular response to water stimulusGO:007146210.371
negative regulation of protein deubiquitinationGO:009008630.368
fas signaling pathwayGO:003633730.367
response to woundingGO:00096111680.366
negative regulation of response to woundingGO:1903035470.364
cellular protein complex assemblyGO:00436231880.361
head developmentGO:00603221080.359
Human
regulation of cell cycle phase transitionGO:19019871260.357
Human
negative regulation of mitotic cell cycleGO:00459301020.357
Human
tissue regenerationGO:004224630.355
lymphocyte activationGO:00466491330.352
regulation of kinase activityGO:00435493140.347
cellular response to estrogen stimulusGO:0071391160.344
positive regulation of kinase activityGO:00336742040.341
striated muscle cell differentiationGO:0051146430.339
regulation of cell activationGO:00508651250.338
regulation of intrinsic apoptotic signaling pathwayGO:2001242720.335
g1 s transition of mitotic cell cycleGO:0000082780.333
Human
muscle organ developmentGO:0007517560.332
cellular component assembly involved in morphogenesisGO:0010927730.332
regulation of cell migrationGO:00303342890.329
cell fate determinationGO:000170930.327
regulation of protein import into nucleusGO:0042306780.320
negative regulation of nf kappab import into nucleusGO:0042347120.318
regulation of skeletal muscle cell proliferationGO:001485710.315
positive regulation of interleukin 8 productionGO:0032757360.314
positive regulation of peptidyl tyrosine phosphorylationGO:0050731850.309
tissue morphogenesisGO:0048729960.308
Mouse
leukocyte mediated cytotoxicityGO:0001909270.307
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822290.299
mononuclear cell proliferationGO:0032943710.298
hematopoietic or lymphoid organ developmentGO:00485341860.297
mitotic cell cycle processGO:19030472860.296
Human
positive regulation of cytokine mediated signaling pathwayGO:0001961120.296
regulation of mononuclear cell proliferationGO:0032944650.295
t cell proliferationGO:0042098450.294
negative regulation of response to external stimulusGO:0032102830.290
regulation of striated muscle cell differentiationGO:0051153250.286
hemopoiesisGO:00300971800.284
mitotic dna integrity checkpointGO:0044774300.284
Human
protein heterooligomerizationGO:0051291160.282
Rat
regulation of protein kinase activityGO:00458592890.281
response to light stimulusGO:0009416870.280
Human
response to acid chemicalGO:0001101660.278
positive regulation of cell motilityGO:20001471770.278
cytoplasmic transportGO:00164823790.275
positive regulation of organelle organizationGO:00106381950.270
substantia nigra developmentGO:0021762450.266
Human
negative regulation of inflammatory responseGO:0050728220.264
negative regulation of hydrolase activityGO:00513461820.261
erythrocyte homeostasisGO:0034101310.258
Human
positive regulation of cytokine productionGO:00018191670.253
anatomical structure formation involved in morphogenesisGO:00486462840.252
Mouse
immune effector processGO:00022521590.251
signal transduction in absence of ligandGO:0038034220.243
positive regulation of neuron apoptotic processGO:004352580.241
protein monoubiquitinationGO:0006513390.240
maintenance of protein location in cellGO:0032507560.240
regulation of cell adhesionGO:00301551660.237
regulation of leukocyte activationGO:00026941150.236
positive regulation of transferase activityGO:00513472270.235
regulation of cytokine mediated signaling pathwayGO:0001959410.235
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.230
regulation of viral release from host cellGO:1902186200.228
regulation of interleukin 8 productionGO:0032677490.227
positive regulation of t cell proliferationGO:0042102330.226
positive regulation of cell cycleGO:00457871400.225
Human
defense response to other organismGO:00985421290.224
positive regulation of cell migrationGO:00303351720.224
regulation of innate immune responseGO:0045088970.223
signal transduction involved in mitotic dna integrity checkpointGO:1902403130.222
Human
regulation of lymphocyte migrationGO:2000401220.218
stress activated protein kinase signaling cascadeGO:0031098940.218
cell cell signalingGO:00072671550.216
negative regulation of synaptic transmissionGO:005080520.216
cellular response to radiationGO:0071478650.214
Human
positive regulation of cell cycle processGO:00900681060.212
Human
regulation of response to external stimulusGO:00321012220.211
cardiovascular system developmentGO:00723582620.211
Mouse
negative regulation of cell cycle g1 s phase transitionGO:1902807290.207
Human
negative regulation of mitotic cell cycle phase transitionGO:1901991850.205
Human
protein modification by small protein conjugationGO:00324463420.203
regulation of stress activated protein kinase signaling cascadeGO:0070302850.202
positive regulation of protein oligomerizationGO:0032461170.201
positive regulation of interferon gamma productionGO:0032729260.201
signal transduction involved in mitotic g1 dna damage checkpointGO:0072431100.199
Human
immune responseGO:00069553070.198
regulation of establishment of protein localizationGO:00702012420.197
tyrosine phosphorylation of stat1 proteinGO:0042508110.196
ion transmembrane transportGO:00342203380.194
response to oxygen levelsGO:00704821000.191
tumor necrosis factor productionGO:0032640430.188
ripoptosome assemblyGO:009734310.186
development of primary male sexual characteristicsGO:0046546230.184
regulation of cell motilityGO:20001452990.183
cellular response to hypoxiaGO:0071456510.182
negative regulation of homeostatic processGO:0032845590.179
reproductive processGO:00224141060.177
developmental growthGO:0048589480.175
cellular response to metal ionGO:0071248430.171
positive regulation of lymphocyte migrationGO:2000403160.171
vesicle mediated transportGO:00161923710.171
regulation of nf kappab import into nucleusGO:0042345220.169
regulation of protein complex assemblyGO:00432541470.168
negative regulation of cell cycle processGO:00109481210.168
Human
modification dependent protein catabolic processGO:00199412090.168
regulation of protein localizationGO:00328802960.168
regulation of response to woundingGO:19030341010.167
negative regulation of protein kinase activityGO:0006469980.166
regulation of protein homooligomerizationGO:0032462110.165
regulation of neuron apoptotic processGO:0043523350.165
negative regulation of necrotic cell deathGO:006054730.165
Mouse
mitotic cell cycle phase transitionGO:00447721620.162
Human
positive regulation of peptidyl serine phosphorylationGO:0033138420.161
tumor necrosis factor mediated signaling pathwayGO:0033209270.159
osteoclast differentiationGO:0030316210.156
leukocyte mediated immunityGO:0002443590.156
neuron deathGO:0070997650.156
response to decreased oxygen levelsGO:0036293960.153
regulation of protein secretionGO:0050708860.149
actomyosin structure organizationGO:0031032590.149
striated muscle tissue developmentGO:0014706590.146
positive regulation of tumor necrosis factor productionGO:0032760210.145
plasma membrane raft assemblyGO:004485440.144
response to lipidGO:00339932060.142
Rat
regulation of lymphocyte mediated immunityGO:0002706330.140
negative regulation of protein import into nucleusGO:0042308300.140
negative regulation of protein serine threonine kinase activityGO:0071901570.139
single organism cellular localizationGO:19025803320.137
tumor necrosis factor superfamily cytokine productionGO:0071706450.135
positive regulation of interleukin 1 beta secretionGO:0050718110.135
regulation of secretionGO:00510461940.134
syncytium formation by plasma membrane fusionGO:000076820.134
protein localization to organelleGO:00333652800.134
interleukin 8 productionGO:0032637510.132
regulation of defense response to virusGO:0050688330.128
morphogenesis of an epitheliumGO:0002009600.128
Mouse
type i interferon signaling pathwayGO:0060337110.128
activation of innate immune responseGO:0002218550.128
maintenance of locationGO:00512351120.124
nuclear importGO:00511701060.124
signal transduction involved in mitotic dna damage checkpointGO:1902402130.123
Human
regulation of cellular component biogenesisGO:00440872810.122
regulation of transcription factor import into nucleusGO:0042990390.121
endosomal transportGO:00161971290.121
organic hydroxy compound metabolic processGO:19016151470.120
response to drugGO:0042493810.120
response to metal ionGO:0010038840.120
Rat
t cell migrationGO:0072678160.119
negative regulation of phosphate metabolic processGO:00459362670.118
protein targeting to nucleusGO:00447441040.117
regulation of nik nf kappab signalingGO:1901222110.116
regulation of leukocyte proliferationGO:0070663670.116
regulation of leukocyte mediated immunityGO:0002703380.113
cell cycle checkpointGO:00000751170.111
Human
regulation of t cell proliferationGO:0042129420.111
regulation of protein serine threonine kinase activityGO:00719001790.111
leukocyte homeostasisGO:000177670.109
cellular response to oxygen levelsGO:0071453550.109
muscle structure developmentGO:0061061980.108
nucleocytoplasmic transportGO:00069131760.108
nitrogen compound transportGO:00717051910.108
regulation of protein oligomerizationGO:0032459260.107
protein polyubiquitinationGO:00002091100.107
carbohydrate derivative transportGO:1901264200.106
determination of adult lifespanGO:000834020.106
cellular response to decreased oxygen levelsGO:0036294510.106
regulation of erk1 and erk2 cascadeGO:0070372990.105
negative regulation of intracellular protein transportGO:0090317420.105
protein import into nucleusGO:00066061040.103
regulation of stress activated mapk cascadeGO:0032872840.103
response to lipopolysaccharideGO:0032496700.102
Rat
chemotaxisGO:00069351570.102
regulation of leukocyte migrationGO:0002685630.101
caveola assemblyGO:007083640.099
t cell selectionGO:004505840.098
regulation of type i interferon mediated signaling pathwayGO:006033890.098
response to bacteriumGO:00096171440.097
Rat
positive regulation of cellular extravasationGO:000269330.096
response to cycloheximideGO:004689810.094
regulation of tyrosine phosphorylation of stat1 proteinGO:0042510110.093
lymphocyte proliferationGO:0046651700.093
positive regulation of protein complex assemblyGO:0031334860.091
negative regulation of vasculature developmentGO:1901343430.091
cellular response to type i interferonGO:0071357120.090
protein targetingGO:00066051870.090
synaptic transmissionGO:0007268610.089
actin filament based processGO:00300292240.089
intracellular protein transportGO:00068862700.089
regulation of tumor necrosis factor superfamily cytokine productionGO:1903555440.086
peptidyl tyrosine dephosphorylationGO:0035335360.086
skeletal muscle cell proliferationGO:001485610.086
mapk cascadeGO:00001652880.085
tissue homeostasisGO:0001894630.082
immune response activating cell surface receptor signaling pathwayGO:0002429450.082

CASP8 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
hypersensitivity reaction diseaseDOID:0060056251.000
Human
immune system diseaseDOID:29141551.000
Human
hypersensitivity reaction type iv diseaseDOID:291660.991
Human
cancerDOID:1621670.862
disease of cellular proliferationDOID:145661740.862
gastrointestinal system cancerDOID:3119520.596
organ system cancerDOID:00506861640.596
stomach cancerDOID:10534120.358
Human