Homo sapiens

27 known processes

DIO2

deiodinase, iodothyronine, type II

(Aliases: TXDI2,D2,5DII,SelY)

DIO2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
ras protein signal transductionGO:0007265730.166
cell developmentGO:00484683280.155
small gtpase mediated signal transductionGO:0007264780.149
negative regulation of multicellular organismal processGO:00512413170.147
system processGO:00030083490.143
cellular ketone metabolic processGO:0042180800.140
regulation of cell migrationGO:00303342890.138
regulation of cell differentiationGO:00455953930.122
cellular amine metabolic processGO:0044106410.119
regulation of locomotionGO:00400123290.112
cell adhesionGO:00071553250.108
regulation of cellular amine metabolic processGO:0033238110.103
cellular amino acid metabolic processGO:00065201160.102
glycosyl compound catabolic processGO:19016584130.099
rho protein signal transductionGO:0007266260.097
circulatory system developmentGO:00723592620.096
regulation of cell motilityGO:20001452990.093
negative regulation of developmental processGO:00510932470.093
positive regulation of hydrolase activityGO:00513453310.093
regulation of cellular ketone metabolic processGO:0010565500.093
purine ribonucleoside metabolic processGO:00461284370.092
positive regulation of transportGO:00510503360.092
g protein coupled receptor signaling pathwayGO:00071862070.091
purine ribonucleotide catabolic processGO:00091544040.091
amine metabolic processGO:0009308440.090
purine nucleotide catabolic processGO:00061954050.089
organophosphate catabolic processGO:00464344300.089
positive regulation of locomotionGO:00400171860.089
ribonucleoside catabolic processGO:00424544060.088
nucleoside catabolic processGO:00091644080.088
guanosine containing compound metabolic processGO:19010682440.087
regulation of cellular amino acid metabolic processGO:000652160.086
cardiovascular system developmentGO:00723582620.085
ribonucleoside triphosphate metabolic processGO:00091994120.081
circulatory system processGO:00030131130.081
nucleoside triphosphate metabolic processGO:00091414220.080
purine ribonucleoside triphosphate catabolic processGO:00092073910.080
ribonucleoside triphosphate catabolic processGO:00092033910.079
response to oxygen containing compoundGO:19017003690.079
purine ribonucleoside triphosphate metabolic processGO:00092054110.079
ribonucleotide catabolic processGO:00092614050.079
epithelium developmentGO:00604292270.078
purine ribonucleoside catabolic processGO:00461303980.076
purine nucleoside triphosphate metabolic processGO:00091444120.075
regulation of purine nucleotide metabolic processGO:19005422640.073
nucleotide catabolic processGO:00091664080.072
purine nucleoside triphosphate catabolic processGO:00091463920.072
enzyme linked receptor protein signaling pathwayGO:00071673030.072
biological adhesionGO:00226103310.071
regulation of nucleotide metabolic processGO:00061402690.071
positive regulation of cellular amine metabolic processGO:003324070.071
skeletal system developmentGO:0001501790.070
cellular response to endogenous stimulusGO:00714953360.070
positive regulation of developmental processGO:00510943140.070
defense responseGO:00069523150.069
negative regulation of transportGO:00510511760.069
cell morphogenesisGO:00009022960.068
metal ion transportGO:00300012720.068
nervous system developmentGO:00073992930.067
purine containing compound catabolic processGO:00725234110.067
anatomical structure formation involved in morphogenesisGO:00486462840.067
positive regulation of cell motilityGO:20001471770.066
regulation of purine nucleotide catabolic processGO:00331212050.066
blood vessel developmentGO:00015681720.066
cellular ion homeostasisGO:00068731680.066
positive regulation of cellular amino acid metabolic processGO:004576430.065
cellular component morphogenesisGO:00329893140.065
positive regulation of nucleotide metabolic processGO:00459812300.064
purine nucleoside catabolic processGO:00061523980.064
membrane organizationGO:00610242920.063
nucleoside triphosphate catabolic processGO:00091433940.062
response to biotic stimulusGO:00096072760.062
positive regulation of cellular component organizationGO:00511303760.061
nucleoside phosphate catabolic processGO:19012924120.061
regulation of nucleotide catabolic processGO:00308112050.060
regulation of cellular component movementGO:00512703340.059
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.059
single organism membrane organizationGO:00448022680.058
positive regulation of phosphorylationGO:00423273940.058
immune responseGO:00069553070.058
gtp catabolic processGO:00061842370.057
negative regulation of protein metabolic processGO:00512483910.057
positive regulation of nucleotide catabolic processGO:00308131850.057
gtp metabolic processGO:00460392390.056
ion transmembrane transportGO:00342203380.056
response to lipidGO:00339932060.056
mapk cascadeGO:00001652880.055
regulation of cell developmentGO:00602841610.054
ion homeostasisGO:00508012300.054
post embryonic developmentGO:000979120.054
signal transduction by phosphorylationGO:00230142970.053
regulation of protein localizationGO:00328802960.053
positive regulation of purine nucleotide metabolic processGO:19005442270.052
regulation of cellular component biogenesisGO:00440872810.052
chemical homeostasisGO:00488783060.052
positive regulation of mapk cascadeGO:00434101900.052
blood circulationGO:00080151130.052
actin filament based processGO:00300292240.051
regulation of gtpase activityGO:00430871800.051
muscle contractionGO:0006936730.050
vasculature developmentGO:00019441810.050
positive regulation of nucleoside metabolic processGO:00459791860.050
secretionGO:00469032540.050
response to external biotic stimulusGO:00432072610.050
positive regulation of cell proliferationGO:00082843010.049
positive regulation of cellular component movementGO:00512721810.049
regulation of nucleoside metabolic processGO:00091182090.049
response to abiotic stimulusGO:00096283360.049
cation transportGO:00068123310.049
regulation of protein kinase activityGO:00458592890.048
cytokine productionGO:00018162470.048
positive regulation of catabolic processGO:00098963100.048
regulation of anatomical structure morphogenesisGO:00226032860.047
response to woundingGO:00096111680.047
endomembrane system organizationGO:00102561960.046
secretion by cellGO:00329402260.046
regulation of gtp catabolic processGO:00331241800.045
locomotory behaviorGO:000762610.045
negative regulation of cellular protein metabolic processGO:00322693530.045
ossificationGO:00015031210.045
negative regulation of phosphorus metabolic processGO:00105632670.045
negative regulation of cellular component organizationGO:00511292350.044
regulation of mapk cascadeGO:00434082620.044
positive regulation of cellular catabolic processGO:00313312840.044
cytoplasmic transportGO:00164823790.044
negative regulation of cell deathGO:00605483450.044
segmentationGO:003528240.044
muscle system processGO:0003012810.043
guanosine containing compound catabolic processGO:19010692390.043
blood vessel morphogenesisGO:00485141620.043
positive regulation of protein phosphorylationGO:00019343130.043
negative regulation of catalytic activityGO:00430863350.042
regulation of intracellular transportGO:00323861950.042
positive regulation of cell differentiationGO:00455972110.042
negative regulation of phosphate metabolic processGO:00459362670.042
female gamete generationGO:000729220.042
response to other organismGO:00517072610.041
positive regulation of purine nucleotide catabolic processGO:00331231850.041
regulation of proteolysisGO:00301622930.041
cellular homeostasisGO:00197251960.041
regulation of kinase activityGO:00435493140.041
response to organic cyclic compoundGO:00140702040.041
cell projection organizationGO:00300302520.041
skin developmentGO:0043588760.040
taxisGO:00423301570.040
lipid metabolic processGO:00066293810.040
ameboidal type cell migrationGO:00016671350.040
negative regulation of cell differentiationGO:00455961710.040
positive regulation of immune system processGO:00026842830.040
positive regulation of gtpase activityGO:00435471660.040
response to growth factorGO:00708482050.040
positive regulation of ras gtpase activityGO:00323201170.040
cellular response to oxygen containing compoundGO:19017012760.039
regulation of cytokine productionGO:00018172320.039
sequestering of metal ionGO:0051238240.039
vesicle mediated transportGO:00161923710.039
protein localization to organelleGO:00333652800.038
tissue morphogenesisGO:0048729960.038
connective tissue developmentGO:0061448390.038
regulation of transferase activityGO:00513383550.038
regulation of establishment of protein localizationGO:00702012420.038
single organism cellular localizationGO:19025803320.038
cellular response to organic cyclic compoundGO:00714071270.038
negative regulation of cell proliferationGO:00082852280.038
transmembrane transportGO:00550853990.038
multicellular organismal agingGO:001025930.038
negative regulation of immune system processGO:00026831360.037
cellular response to growth factor stimulusGO:00713631970.037
epidermis morphogenesisGO:004873030.036
oogenesisGO:004847720.036
intracellular protein transportGO:00068862700.036
metal ion homeostasisGO:00550651690.036
single organism cell adhesionGO:00986021790.036
cellular divalent inorganic cation homeostasisGO:00725031280.036
glycoprotein metabolic processGO:00091001100.035
epithelial cell migrationGO:00106311190.035
negative regulation of cell migrationGO:00303361020.035
divalent inorganic cation homeostasisGO:00725071360.035
cation homeostasisGO:00550801890.035
positive regulation of cell deathGO:00109422630.035
actin cytoskeleton organizationGO:00300362070.034
regulation of cell adhesionGO:00301551660.034
protein catabolic processGO:00301633250.034
regulation of ion transportGO:00432691890.034
regulation of response to external stimulusGO:00321012220.034
growthGO:00400072020.034
regulation of small gtpase mediated signal transductionGO:00510561560.034
regulation of ras protein signal transductionGO:00465781550.034
purine ribonucleotide biosynthetic processGO:0009152790.033
cell morphogenesis involved in differentiationGO:00009041440.033
cellular metal ion homeostasisGO:00068751460.033
tube developmentGO:00352951250.033
neurogenesisGO:00220081690.033
protein maturationGO:00516042330.033
cardiac muscle cell contractionGO:008600340.033
calcium ion homeostasisGO:00550741220.032
determination of adult lifespanGO:000834020.032
regulation of protein transportGO:00512232130.032
cellular cation homeostasisGO:00300031630.032
positive regulation of programmed cell deathGO:00430682490.032
regulation of cytoplasmic transportGO:19036491490.032
neurological system processGO:00508771630.031
cellular lipid metabolic processGO:00442553030.031
formation of primary germ layerGO:0001704420.031
wnt signaling pathwayGO:00160551560.031
regulation of cytoskeleton organizationGO:00514931770.031
cardiac muscle contractionGO:0060048340.031
sequestering of calcium ionGO:0051208170.031
positive regulation of cell migrationGO:00303351720.031
regulation of cell morphogenesisGO:00226041530.031
positive regulation of cytokine productionGO:00018191670.031
cell growthGO:00160491600.030
muscle structure developmentGO:0061061980.030
endothelial cell migrationGO:0043542860.030
cellular calcium ion homeostasisGO:00068741170.030
inorganic ion transmembrane transportGO:00986602310.030
regulation of immune responseGO:00507762010.030
apoptotic signaling pathwayGO:00971902680.030
chemotaxisGO:00069351570.030
negative regulation of hydrolase activityGO:00513461820.029
negative regulation of programmed cell deathGO:00430693210.029
glial cell migrationGO:000834740.029
organonitrogen compound biosynthetic processGO:19015662000.029
regulation of cellular response to stressGO:00801352440.029
tissue migrationGO:00901301190.029
hair follicle morphogenesisGO:003106920.029
regulation of secretion by cellGO:19035301770.029
maintenance of locationGO:00512351120.029
calcium ion transportGO:00068161470.029
regulation of cell cycleGO:00517263930.029
regenerationGO:003109940.029
organ morphogenesisGO:00098871470.028
response to nitrogen compoundGO:19016981840.028
positive regulation of gtp catabolic processGO:00331261660.028
regulation of actin filament based processGO:00329701410.028
cellular response to dna damage stimulusGO:00069743790.028
cell chemotaxisGO:00603261120.028
positive regulation of apoptotic processGO:00430652460.028
generation of neuronsGO:00486991520.028
motor neuron axon guidanceGO:000804520.028
plasma membrane organizationGO:00070091150.028
cell activationGO:00017752130.028
cellular macromolecule catabolic processGO:00442653800.027
neuron differentiationGO:00301821380.027
regulation of cell cycle processGO:00105642660.027
epithelial cell proliferationGO:00506731280.027
negative regulation of embryonic developmentGO:004599240.027
neuromuscular junction developmentGO:000752830.027
regulation of secretionGO:00510461940.027
regulation of wnt signaling pathwayGO:00301111230.027
cellular chemical homeostasisGO:00550821800.027
morphogenesis of embryonic epitheliumGO:001633140.027
blastoderm segmentationGO:000735020.027
osteoblast differentiationGO:0001649920.027
cell aggregationGO:009874310.027
negative regulation of apoptotic processGO:00430663160.027
stem cell differentiationGO:0048863930.027
regulation of endopeptidase activityGO:00525481700.026
single organismal cell cell adhesionGO:00163371480.026
canonical wnt signaling pathwayGO:00600701160.026
divalent inorganic cation transportGO:00725111580.026
dephosphorylationGO:00163112090.026
response to bacteriumGO:00096171440.026
positive regulation of protein kinase activityGO:00458601900.026
response to cytokineGO:00340972320.026
regulation of epithelial cell proliferationGO:00506781130.026
regulation of canonical wnt signaling pathwayGO:0060828880.026
response to radiationGO:00093141510.026
embryonic morphogenesisGO:0048598850.026
brain developmentGO:0007420970.026
neuron projection developmentGO:00311751060.026
inner ear morphogenesisGO:004247240.026
negative regulation of locomotionGO:00400131180.026
angiogenesisGO:00015251470.026
posttranscriptional regulation of gene expressionGO:00106082130.026
carbohydrate derivative biosynthetic processGO:19011372070.026
regulation of protein serine threonine kinase activityGO:00719001790.025
regulation of cell morphogenesis involved in differentiationGO:0010769830.025
positive regulation of transferase activityGO:00513472270.025
digestive system developmentGO:0055123750.025
non canonical wnt signaling pathway via mapk cascadeGO:003803040.025
anterior posterior axis specification embryoGO:000859520.025
epithelium migrationGO:00901321190.025
cellular response to transforming growth factor beta stimulusGO:0071560940.025
protein localization to nucleusGO:00345041360.025
regulation of homeostatic processGO:00328441210.025
negative regulation of cell motilityGO:20001461040.025
epithelial cell differentiationGO:00308551410.025
central nervous system developmentGO:00074171230.024
purine containing compound biosynthetic processGO:0072522880.024
muscle tissue developmentGO:0060537620.024
morphogenesis of an epitheliumGO:0002009600.024
small molecule biosynthetic processGO:00442831570.024
regulation of metal ion transportGO:00109591200.024
organophosphate biosynthetic processGO:00904071630.024
innate immune responseGO:00450871780.024
response to organonitrogen compoundGO:00102431560.024
reactive oxygen species metabolic processGO:0072593750.024
regulation of hormone levelsGO:00108171250.024
embryonic epithelial tube formationGO:000183840.024
wound healingGO:00420601150.024
somatic muscle developmentGO:000752510.023
negative regulation of cell cycleGO:00457861930.023
mesenchymal cell differentiationGO:0048762520.023
protein processingGO:00164852260.023
neuron developmentGO:00486661130.023
response to inorganic substanceGO:00100351270.023
head developmentGO:00603221080.023
negative regulation of phosphorylationGO:00423261740.023
photoreceptor cell differentiationGO:004653020.023
cell substrate adhesionGO:00315891320.023
divalent metal ion transportGO:00708381520.023
anterior posterior axis specificationGO:000994820.023
heart developmentGO:0007507950.023
proteoglycan metabolic processGO:0006029290.023
protein modification by small protein conjugationGO:00324463420.022
mesenchymal cell developmentGO:0014031500.022
positive regulation of epithelial cell proliferationGO:0050679650.022
leukocyte migrationGO:00509001070.022
response to hormoneGO:00097251750.022
organ formationGO:004864530.022
cellular response to lipidGO:00713961270.022
positive regulation of ossificationGO:0045778320.022
protein targetingGO:00066051870.022
positive regulation of ion transportGO:0043270870.022
multicellular organismal metabolic processGO:0044236340.022
cardiac muscle tissue developmentGO:0048738390.022
cellular macromolecular complex assemblyGO:00346223240.022
regulation of ras gtpase activityGO:00323181280.022
endochondral bone morphogenesisGO:006035030.022
negative regulation of protein modification processGO:00314002000.022
cellular response to nitrogen compoundGO:19016991440.021
regulation of ion homeostasisGO:2000021730.021
regulation of defense responseGO:00313471540.021
oocyte developmentGO:004859910.021
peptidyl tyrosine modificationGO:00182121700.021
ribose phosphate biosynthetic processGO:0046390820.021
cyclic nucleotide metabolic processGO:0009187820.021
regulation of dna metabolic processGO:00510521530.021
protein ubiquitinationGO:00165673140.021
positive regulation of cellular component biogenesisGO:00440891580.021
lung alveolus developmentGO:004828640.021
hindbrain developmentGO:003090230.021
oocyte differentiationGO:000999420.021
regulation of cyclic nucleotide biosynthetic processGO:0030802490.021
digestive tract developmentGO:0048565750.021
urogenital system developmentGO:0001655650.020
tissue regenerationGO:004224630.020
positive regulation of cytoskeleton organizationGO:0051495830.020
regulation of cell growthGO:00015581350.020
leukocyte activationGO:00453211640.020
negative regulation of cellular component movementGO:00512711060.020
nitrogen compound transportGO:00717051910.020
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280690.020
heart contractionGO:0060047620.020
cytosolic calcium ion homeostasisGO:0051480890.020
mitotic cell cycle processGO:19030472860.020
regulation of protein catabolic processGO:00421761550.020
positive regulation of organelle organizationGO:00106381950.020
peripheral nervous system developmentGO:000742220.020
positive regulation of cell developmentGO:0010720920.020
mitotic cell cycleGO:00002783260.020
nucleotide biosynthetic processGO:00091651090.020
regulation of peptidase activityGO:00525471800.020
response to transforming growth factor betaGO:0071559940.020
biomineral tissue developmentGO:0031214390.020
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.020
positive regulation of kinase activityGO:00336742040.019
cellular protein catabolic processGO:00442572610.019
peptidyl tyrosine phosphorylationGO:00181081700.019
establishment of protein localization to organelleGO:00725941720.019
regulation of nervous system developmentGO:0051960880.019
regulation of cell activationGO:00508651250.019
inorganic cation transmembrane transportGO:00986621940.019
regulation of cysteine type endopeptidase activityGO:20001161270.019
actin mediated cell contractionGO:0070252120.019
anion transportGO:00068201610.019
metencephalon developmentGO:002203720.019
detection of mechanical stimulusGO:005098240.019
protein localization to membraneGO:00726571600.019
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.019
positive regulation of immune responseGO:00507781590.019
regulation of apoptotic signaling pathwayGO:20012331750.019
positive regulation of proteolysisGO:00458621420.019
positive regulation of cytosolic calcium ion concentrationGO:0007204820.018
regulation of multi organism processGO:00439001570.018
protein oligomerizationGO:00512591730.018
positive regulation of secretionGO:00510471160.018
negative regulation of intracellular signal transductionGO:19025321830.018
soft palate developmentGO:006002330.018
regulation of angiogenesisGO:0045765920.018
positive regulation of epithelial cell proliferation involved in wound healingGO:006005430.018
chromatin organizationGO:00063253510.018
positive regulation of protein serine threonine kinase activityGO:00719021190.018
negative regulation of cellular amino acid metabolic processGO:004576320.018
hormone metabolic processGO:0042445610.018
carbohydrate metabolic processGO:00059752070.018
lipid biosynthetic processGO:00086101770.018
regulation of protein processingGO:00706131500.018
regulation of axon guidanceGO:190266730.018
positive regulation of secretion by cellGO:19035321080.018
nucleoside phosphate biosynthetic processGO:19012931090.018
regulation of growthGO:00400081650.018
proteolysis involved in cellular protein catabolic processGO:00516032440.018
purine ribonucleoside monophosphate metabolic processGO:00091671860.018
striated muscle contractionGO:0006941520.018
organic hydroxy compound metabolic processGO:19016151470.018
matingGO:000761810.018
negative regulation of organelle organizationGO:00106391260.018
nuclear importGO:00511701060.018
nucleocytoplasmic transportGO:00069131760.018
regulation of actin cytoskeleton organizationGO:00329561160.018
regulation of neurogenesisGO:0050767820.018
actin filament based movementGO:0030048170.018
carboxylic acid biosynthetic processGO:0046394970.018
renal system developmentGO:0072001630.018
cellular response to organonitrogen compoundGO:00714171240.017
nerve developmentGO:002167540.017
regulation of system processGO:00440571010.017
sex determinationGO:000753030.017
negative regulation of cellular amine metabolic processGO:003323930.017
tube morphogenesisGO:0035239950.017
camp biosynthetic processGO:0006171470.017
regulation of mitotic cell cycleGO:00073461890.017
forebrain generation of neuronsGO:002187230.017
sensory perceptionGO:00076001030.017
behaviorGO:00076101120.017
tripartite regional subdivisionGO:000735120.017
regulation of rho protein signal transductionGO:0035023790.017
response to molecule of bacterial originGO:0002237820.017
cell projection morphogenesisGO:00488581290.017
regulation of calcium ion transportGO:0051924790.017
reproductive processGO:00224141060.017
negative regulation of kidney developmentGO:009018520.017
organelle assemblyGO:00709251760.017
regulation of protein maturationGO:19033171500.017
regulation of sequence specific dna binding transcription factor activityGO:00510902110.017
second messenger mediated signalingGO:0019932780.017
establishment of protein localization to membraneGO:00901501210.017
copulationGO:000762010.017
regulation of membrane potentialGO:0042391950.017
skeletal system morphogenesisGO:0048705240.017
regulation of transmembrane transportGO:00347621390.017
salivary gland morphogenesisGO:000743540.017
positive regulation of intracellular transportGO:00323881040.017
negative regulation of protein processingGO:00109551420.017
interspecies interaction between organismsGO:00444191560.017
cellular protein complex assemblyGO:00436231880.017
activation of protein kinase activityGO:0032147900.017
endodermal cell differentiationGO:0035987310.016
positive regulation of cell adhesionGO:0045785840.016
purine nucleoside monophosphate metabolic processGO:00091261860.016
protein importGO:00170381300.016
regulation of leukocyte activationGO:00026941150.016
cell matrix adhesionGO:0007160850.016
stem cell developmentGO:0048864690.016
cell fate determinationGO:000170930.016
regulation of map kinase activityGO:00434051080.016
regulation of peptidyl tyrosine phosphorylationGO:00507301080.016
negative regulation of proteolysisGO:00458611320.016
associative learningGO:000830610.016
endocytosisGO:00068971590.016
compound eye developmentGO:004874910.016
rhythmic behaviorGO:000762220.016
spermatid differentiationGO:004851540.016
positive regulation of cytoplasmic transportGO:1903651820.016
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.016
negative regulation of cell growthGO:0030308830.016
regulation of response to woundingGO:19030341010.016
organic acid biosynthetic processGO:0016053970.016
cell cell signalingGO:00072671550.016
limbic system developmentGO:002176130.016
extracellular structure organizationGO:0043062410.016
memoryGO:000761330.016
response to axon injuryGO:004867810.016
embryo developmentGO:00097901230.016
camp metabolic processGO:0046058610.016
myeloid leukocyte migrationGO:0097529620.016
regulation of synaptic plasticityGO:004816730.016
nucleoside monophosphate metabolic processGO:00091231910.016

DIO2 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:172230.097
cardiovascular system diseaseDOID:12871060.050
nervous system diseaseDOID:8634310.034
central nervous system diseaseDOID:3311860.034
heart diseaseDOID:114680.032
muscular diseaseDOID:00800001140.024
muscle tissue diseaseDOID:661130.024
myopathyDOID:4231040.024
cardiomyopathyDOID:0050700500.022
connective tissue diseaseDOID:651090.020
sensory system diseaseDOID:00501552030.020
intrinsic cardiomyopathyDOID:0060036500.019
disease of metabolismDOID:00146672950.017
brain diseaseDOID:936730.017