Homo sapiens

61 known processes

APLF

aprataxin and PNKP like factor

(Aliases: MGC47799,Xip1,FLJ16593,C2orf13,APFL,PALF)

APLF biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
dna ligation involved in dna repairGO:005110341.000
immunoglobulin v d j recombinationGO:003315210.999
pro b cell differentiationGO:000232810.999
v d j recombinationGO:003315130.995
dna ligationGO:0006266100.990
single strand break repairGO:000001260.947
somatic stem cell maintenanceGO:003501940.926
hematopoietic progenitor cell differentiationGO:0002244380.874
dna recombinationGO:0006310770.858
double strand break repairGO:00063021010.849
somatic diversification of immunoglobulins involved in immune responseGO:000220830.839
isotype switchingGO:004519030.822
nucleotide excision repairGO:0006289310.713
non recombinational repairGO:0000726140.697
fibroblast proliferationGO:0048144330.630
somatic recombination of immunoglobulin gene segmentsGO:001644740.629
t cell differentiation in thymusGO:003307740.604
response to gamma radiationGO:0010332140.560
positive regulation of cell differentiationGO:00455972110.535
positive regulation of cell developmentGO:0010720920.525
hematopoietic or lymphoid organ developmentGO:00485341860.517
positive regulation of developmental processGO:00510943140.509
positive regulation of fibroblast proliferationGO:0048146210.443
leukocyte mediated immunityGO:0002443590.435
replicative cell agingGO:000130230.430
immune effector processGO:00022521590.405
immune responseGO:00069553070.401
t cell activationGO:0042110990.391
dna damage response detection of dna damageGO:004276930.380
regulation of cell differentiationGO:00455953930.369
double strand break repair via nonhomologous end joiningGO:0006303100.367
positive regulation of cell proliferationGO:00082843010.367
lymphoid progenitor cell differentiationGO:000232030.364
lymphocyte mediated immunityGO:0002449480.360
positive regulation of neurogenesisGO:0050769490.360
immune system developmentGO:00025201950.354
cell activation involved in immune responseGO:0002263300.351
lymphocyte activationGO:00466491330.349
cell activationGO:00017752130.338
stem cell differentiationGO:0048863930.283
regulation of fibroblast proliferationGO:0048145320.270
response to ionizing radiationGO:0010212650.267
cell agingGO:0007569520.264
b cell activationGO:0042113330.261
regulation of neurogenesisGO:0050767820.253
leukocyte activation involved in immune responseGO:0002366300.252
negative regulation of neuron apoptotic processGO:0043524230.248
somatic recombination of immunoglobulin genes involved in immune responseGO:000220430.245
nervous system developmentGO:00073992930.241
negative regulation of cell deathGO:00605483450.239
hemopoiesisGO:00300971800.231
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002460400.220
negative regulation of apoptotic processGO:00430663160.219
somatic diversification of immune receptorsGO:000220080.215
leukocyte activationGO:00453211640.215
hematopoietic stem cell differentiationGO:006021840.212
stem cell maintenanceGO:0019827190.207
negative regulation of programmed cell deathGO:00430693210.197
regulation of nervous system developmentGO:0051960880.194
response to abiotic stimulusGO:00096283360.193
b cell mediated immunityGO:0019724100.190
leukocyte differentiationGO:0002521980.188
generation of neuronsGO:00486991520.184
response to radiationGO:00093141510.177
immunoglobulin mediated immune responseGO:0016064100.169
cell type specific apoptotic processGO:00972851250.166
negative regulation of developmental processGO:00510932470.147
immunoglobulin production involved in immunoglobulin mediated immune responseGO:000238150.134
positive regulation of nervous system developmentGO:0051962540.130
central nervous system developmentGO:00074171230.126
production of molecular mediator of immune responseGO:0002440370.124
lymphocyte activation involved in immune responseGO:0002285200.123
regulation of neuron deathGO:1901214560.123
lymphocyte differentiationGO:0030098350.122
response to oxygen containing compoundGO:19017003690.117
single organism carbohydrate metabolic processGO:00447231930.116
regulation of neuron apoptotic processGO:0043523350.114
t cell differentiationGO:0030217290.114
glycoprotein metabolic processGO:00091001100.110
somatic diversification of immunoglobulinsGO:001644560.110
cellular response to dna damage stimulusGO:00069743790.107
chromatin assembly or disassemblyGO:0006333780.106
negative regulation of cell differentiationGO:00455961710.106
glycoprotein biosynthetic processGO:0009101910.097
dna conformation changeGO:00711031130.097
protein glycosylationGO:0006486620.093
adaptive immune responseGO:0002250490.091
dna repairGO:00062811980.084
neuron deathGO:0070997650.083
carbohydrate derivative biosynthetic processGO:19011372070.082
protein poly adp ribosylationGO:007021230.078
base excision repairGO:0006284210.078
immunoglobulin productionGO:0002377120.076
negative regulation of neuron deathGO:1901215320.075
regulation of ligase activityGO:0051340290.074
amine metabolic processGO:0009308440.070
neuron apoptotic processGO:0051402390.069
nucleoside triphosphate catabolic processGO:00091433940.066
regulation of cell developmentGO:00602841610.065
carbohydrate metabolic processGO:00059752070.063
nucleoside catabolic processGO:00091644080.063
macromolecule glycosylationGO:0043413630.061
protein autoprocessingGO:001654040.060
purine nucleoside triphosphate catabolic processGO:00091463920.058
dephosphorylationGO:00163112090.058
stem cell developmentGO:0048864690.057
chordate embryonic developmentGO:0043009340.057
neurogenesisGO:00220081690.056
nucleoside triphosphate metabolic processGO:00091414220.055
cellular amine metabolic processGO:0044106410.053
atp metabolic processGO:00460341760.048
cell developmentGO:00484683280.048
somatic cell dna recombinationGO:001644460.045
glycosylationGO:0070085710.044
nucleic acid phosphodiester bond hydrolysisGO:00903051020.043
cellular macromolecule catabolic processGO:00442653800.042
regulation of dna metabolic processGO:00510521530.042
cellular ketone metabolic processGO:0042180800.041
nucleoside monophosphate catabolic processGO:00091251590.040
post embryonic developmentGO:000979120.040
biological adhesionGO:00226103310.040
purine containing compound catabolic processGO:00725234110.039
glycosyl compound catabolic processGO:19016584130.039
regulation of cellular amino acid metabolic processGO:000652160.038
purine nucleoside catabolic processGO:00061523980.038
ribonucleotide catabolic processGO:00092614050.038
regulation of cellular amine metabolic processGO:0033238110.038
positive regulation of ligase activityGO:0051351190.037
dna replicationGO:00062601160.036
regulation of growth rateGO:004000910.036
system processGO:00030083490.036
oxidation reduction processGO:00551143960.034
cellular amino acid metabolic processGO:00065201160.033
response to oxidative stressGO:00069791210.033
purine ribonucleotide catabolic processGO:00091544040.032
organophosphate catabolic processGO:00464344300.032
purine ribonucleoside monophosphate metabolic processGO:00091671860.031
regulation of cellular ketone metabolic processGO:0010565500.031
negative regulation of phosphorus metabolic processGO:00105632670.030
response to reactive oxygen speciesGO:0000302610.029
regulation of protein kinase activityGO:00458592890.029
apoptotic signaling pathwayGO:00971902680.029
cellular response to oxidative stressGO:0034599850.029
circulatory system developmentGO:00723592620.029
regulation of kinase activityGO:00435493140.028
nucleotide catabolic processGO:00091664080.028
positive regulation of cellular component organizationGO:00511303760.027
telomere organizationGO:0032200330.027
positive regulation of cellular catabolic processGO:00313312840.027
nucleoside monophosphate metabolic processGO:00091231910.027
protein adp ribosylationGO:000647190.027
positive regulation of cellular amine metabolic processGO:003324070.026
single organism cellular localizationGO:19025803320.026
negative regulation of phosphate metabolic processGO:00459362670.026
purine ribonucleoside metabolic processGO:00461284370.026
hippocampus developmentGO:002176610.026
purine nucleotide catabolic processGO:00061954050.026
cellular lipid metabolic processGO:00442553030.025
positive regulation of cellular amino acid metabolic processGO:004576430.025
positive regulation of cell deathGO:00109422630.025
response to growth factorGO:00708482050.025
adult locomotory behaviorGO:000834410.025
response to inorganic substanceGO:00100351270.025
atp catabolic processGO:00062001570.025
ion transmembrane transportGO:00342203380.025
lipid biosynthetic processGO:00086101770.025
negative regulation of catalytic activityGO:00430863350.024
determination of adult lifespanGO:000834020.024
mitochondrion organizationGO:00070051560.024
macromolecule methylationGO:0043414970.024
purine nucleoside triphosphate metabolic processGO:00091444120.024
lipid metabolic processGO:00066293810.024
regulation of nucleotide metabolic processGO:00061402690.023
metal ion transportGO:00300012720.023
cellular response to growth factor stimulusGO:00713631970.023
regulation of dna bindingGO:0051101370.023
ribonucleoside monophosphate metabolic processGO:00091611870.023
covalent chromatin modificationGO:00165692540.023
dna dependent dna replicationGO:0006261440.023
cardiovascular system developmentGO:00723582620.023
cation transportGO:00068123310.023
viral life cycleGO:00190581320.022
enzyme linked receptor protein signaling pathwayGO:00071673030.022
purine ribonucleoside triphosphate metabolic processGO:00092054110.022
meiosis iGO:000712740.022
negative regulation of protein metabolic processGO:00512483910.022
regulation of establishment of protein localizationGO:00702012420.022
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.021
positive regulation of purine nucleotide catabolic processGO:00331231850.021
cellular response to nitrogen compoundGO:19016991440.021
regulation of purine nucleotide catabolic processGO:00331212050.021
regulation of purine nucleotide metabolic processGO:19005422640.021
regenerationGO:003109940.021
cation transmembrane transportGO:00986552380.021
positive regulation of nucleotide catabolic processGO:00308131850.021
dna packagingGO:0006323770.021
inorganic ion transmembrane transportGO:00986602310.021
positive regulation of purine nucleotide metabolic processGO:19005442270.021
protein catabolic processGO:00301633250.021
multi organism cellular processGO:00447641560.020
positive regulation of catabolic processGO:00098963100.020
single organism membrane organizationGO:00448022680.020
purine ribonucleoside triphosphate catabolic processGO:00092073910.020
interspecies interaction between organismsGO:00444191560.020
locomotory behaviorGO:000762610.020
ribonucleoside catabolic processGO:00424544060.020
actin filament based processGO:00300292240.020
positive regulation of gtpase activityGO:00435471660.020
regulation of nucleotide catabolic processGO:00308112050.020
signal transduction by p53 class mediatorGO:0072331720.020
cellular response to oxygen containing compoundGO:19017012760.020
positive regulation of transportGO:00510503360.020
negative regulation of cellular protein metabolic processGO:00322693530.019
regulation of protein stabilityGO:0031647870.019
regulation of cell cycleGO:00517263930.019
positive regulation of apoptotic processGO:00430652460.019
cardiac muscle cell contractionGO:008600340.019
embryo developmentGO:00097901230.019
dna replication independent nucleosome organizationGO:0034724270.019
detection of stimulusGO:0051606850.019
b cell activation involved in immune responseGO:000231250.019
regulation of nucleoside metabolic processGO:00091182090.018
purine ribonucleoside catabolic processGO:00461303980.018
positive regulation of nucleotide metabolic processGO:00459812300.018
ras protein signal transductionGO:0007265730.018
vesicle mediated transportGO:00161923710.018
positive regulation of immune responseGO:00507781590.018
positive regulation of immune system processGO:00026842830.018
limbic system developmentGO:002176130.018
regulation of anatomical structure morphogenesisGO:00226032860.018
chemical homeostasisGO:00488783060.017
regulation of lymphocyte activationGO:00512491030.017
nucleoside phosphate catabolic processGO:19012924120.017
positive regulation of programmed cell deathGO:00430682490.017
ribonucleoside triphosphate metabolic processGO:00091994120.017
regulation of cell cycle processGO:00105642660.017
cellular component morphogenesisGO:00329893140.017
regulation of cellular component movementGO:00512703340.017
protein localization to organelleGO:00333652800.017
protein localization to nucleusGO:00345041360.017
modification dependent protein catabolic processGO:00199412090.016
regulation of transferase activityGO:00513383550.016
positive regulation of proteolysisGO:00458621420.016
histone modificationGO:00165702510.016
rho protein signal transductionGO:0007266260.016
nucleoside phosphate biosynthetic processGO:19012931090.016
nucleotide biosynthetic processGO:00091651090.016
cellular response to endogenous stimulusGO:00714953360.016
actin filament based movementGO:0030048170.016
neuromuscular junction developmentGO:000752830.016
positive regulation of protein transportGO:00512221350.016
guanosine containing compound catabolic processGO:19010692390.016
cellular response to organonitrogen compoundGO:00714171240.016
viral processGO:00160321460.016
negative regulation of protein phosphorylationGO:00019331400.016
regulation of cellular response to stressGO:00801352440.016
response to hydrogen peroxideGO:0042542400.016
positive regulation of hydrolase activityGO:00513453310.016
intracellular receptor signaling pathwayGO:00305221040.016
metencephalon developmentGO:002203720.016
negative regulation of cell cycleGO:00457861930.016
cell adhesionGO:00071553250.016
negative regulation of protein modification processGO:00314002000.016
intrinsic apoptotic signaling pathway by p53 class mediatorGO:0072332370.016
symbiosis encompassing mutualism through parasitismGO:00444031560.016
striated muscle contractionGO:0006941520.016
response to organonitrogen compoundGO:00102431560.015
regulation of cytoskeleton organizationGO:00514931770.015
response to transforming growth factor betaGO:0071559940.015
compound eye developmentGO:004874910.015
inorganic cation transmembrane transportGO:00986621940.015
regulation of glial cell differentiationGO:004568530.015
mitotic cell cycle processGO:19030472860.015
nuclear transportGO:00511691790.015
response to woundingGO:00096111680.015
hindbrain developmentGO:003090230.015
response to decreased oxygen levelsGO:0036293960.015
cell morphogenesisGO:00009022960.015
regulation of protein transportGO:00512232130.015
chromatin modificationGO:00165682980.015
cellular response to reactive oxygen speciesGO:0034614500.015
positive regulation of transferase activityGO:00513472270.015
chemotaxisGO:00069351570.015
regulation of cytokine productionGO:00018172320.015
mitotic cell cycle phase transitionGO:00447721620.015
secretion by cellGO:00329402260.014
regulation of intracellular transportGO:00323861950.014
transmembrane transportGO:00550853990.014
regulation of immune responseGO:00507762010.014
divalent metal ion transportGO:00708381520.014
cellular response to insulin stimulusGO:0032869410.014
positive regulation of kinase activityGO:00336742040.014
single stranded viral rna replication via double stranded dna intermediateGO:003969290.014
negative regulation of cellular amino acid metabolic processGO:004576320.014
positive regulation of gtp catabolic processGO:00331261660.014
cellular response to hormone stimulusGO:00328701250.014
rna processingGO:00063962550.014
regulation of protein localization to nucleusGO:1900180850.014
response to hormoneGO:00097251750.014
positive regulation of protein kinase activityGO:00458601900.014
cellular response to nutrient levelsGO:0031669690.014
cellular response to external stimulusGO:00714961110.014
rab protein signal transductionGO:003248240.014
single organism cell adhesionGO:00986021790.014
membrane organizationGO:00610242920.014
organonitrogen compound biosynthetic processGO:19015662000.014
nuclear importGO:00511701060.014
regulation of cytoplasmic transportGO:19036491490.014
organic acid biosynthetic processGO:0016053970.014
protein localization to membraneGO:00726571600.014
matingGO:000761810.013
regulation of protein serine threonine kinase activityGO:00719001790.013
negative regulation of dna metabolic processGO:0051053570.013
rna polymerase ii transcriptional preinitiation complex assemblyGO:005112340.013
nitrogen compound transportGO:00717051910.013
positive regulation of phosphorylationGO:00423273940.013
protein targetingGO:00066051870.013
calcium ion transportGO:00068161470.013
response to other organismGO:00517072610.013
regulation of secretionGO:00510461940.013
cellular response to peptide hormone stimulusGO:0071375560.013
positive regulation of intracellular protein transportGO:0090316760.013
cytoplasmic transportGO:00164823790.013
positive regulation of nucleoside metabolic processGO:00459791860.013
purine nucleotide biosynthetic processGO:0006164840.013
growthGO:00400072020.013
regulation of cell adhesionGO:00301551660.013
regulation of actin filament based processGO:00329701410.013
divalent inorganic cation transportGO:00725111580.013
response to peptideGO:1901652650.013
negative regulation of immune system processGO:00026831360.013
receptor metabolic processGO:0043112810.013
positive regulation of cell cycleGO:00457871400.013
cell cell signalingGO:00072671550.013
protein maturationGO:00516042330.013
regulation of secretion by cellGO:19035301770.013
regulation of nucleocytoplasmic transportGO:0046822980.013
generation of precursor metabolites and energyGO:0006091680.013
negative regulation of phosphorylationGO:00423261740.013
cell part morphogenesisGO:00329901370.013
neurological system processGO:00508771630.013
agingGO:0007568660.013
regulation of response to dna damage stimulusGO:2001020940.013
i kappab kinase nf kappab signalingGO:00072491660.012
defense responseGO:00069523150.012
wnt signaling pathwayGO:00160551560.012
negative regulation of transportGO:00510511760.012
regulation of protein targetingGO:1903533910.012
reciprocal dna recombinationGO:003582540.012
purine ribonucleoside monophosphate catabolic processGO:00091691580.012
negative regulation of multicellular organismal processGO:00512413170.012
regulation of cell growthGO:00015581350.012
sequestering of metal ionGO:0051238240.012
positive regulation of mapk cascadeGO:00434101900.012
pharynx developmentGO:006046510.012
neuroblast proliferationGO:000740540.012
cell projection morphogenesisGO:00488581290.012
protein ubiquitinationGO:00165673140.012
peptidyl tyrosine modificationGO:00182121700.012
chromatin organizationGO:00063253510.012
regulation of t cell activationGO:0050863770.012
histone lysine methylationGO:0034968500.012
innate immune responseGO:00450871780.012
cellular response to extracellular stimulusGO:0031668720.012
purine ribonucleotide biosynthetic processGO:0009152790.012
positive regulation of ras gtpase activityGO:00323201170.012
cellular response to oxygen radicalGO:007145060.012
circulatory system processGO:00030131130.012
cellular response to ionizing radiationGO:0071479320.012
regulation of response to external stimulusGO:00321012220.012
telomere maintenanceGO:0000723320.012
gtp catabolic processGO:00061842370.012
negative regulation of cellular component organizationGO:00511292350.012
positive regulation of cytoplasmic transportGO:1903651820.012
leukocyte migrationGO:00509001070.012
negative regulation of transferase activityGO:00513481240.012
regulation of ras protein signal transductionGO:00465781550.012
regulation of gtpase activityGO:00430871800.012
positive regulation of synaptic transmissionGO:005080640.012
cell projection organizationGO:00300302520.012
activation of immune responseGO:00022531140.012
anatomical structure homeostasisGO:00602491000.012
regulation of vasculature developmentGO:1901342970.012
segmentationGO:003528240.012
phospholipid metabolic processGO:0006644990.011
reactive oxygen species metabolic processGO:0072593750.011
monocarboxylic acid metabolic processGO:00327871850.011
positive regulation of bindingGO:0051099450.011
blastoderm segmentationGO:000735020.011
intrinsic apoptotic signaling pathwayGO:00971931270.011
cofactor metabolic processGO:0051186870.011
positive regulation of organelle organizationGO:00106381950.011
photoreceptor cell differentiationGO:004653020.011
regulation of growthGO:00400081650.011
rna interferenceGO:001624640.011
regulation of angiogenesisGO:0045765920.011
rna splicingGO:00083801310.011
regulation of cell morphogenesisGO:00226041530.011
positive regulation of smad protein import into nucleusGO:006039180.011
guanosine containing compound metabolic processGO:19010682440.011
protein processingGO:00164852260.011
sensory perception of painGO:001923340.011
establishment of protein localization to membraneGO:00901501210.011
demethylationGO:0070988370.011
intracellular protein transportGO:00068862700.011
response to light stimulusGO:0009416870.011
positive regulation of cellular component movementGO:00512721810.011
response to drugGO:0042493810.011
positive regulation of transcription regulatory region dna bindingGO:200067980.011
negative regulation of protein kinase activityGO:0006469980.011
negative regulation of cellular amine metabolic processGO:003323930.011
regulation of gtp catabolic processGO:00331241800.011
regulation of bindingGO:00510981110.011
signal transduction involved in regulation of gene expressionGO:002301910.011
anion transportGO:00068201610.011
ribose phosphate biosynthetic processGO:0046390820.011
response to hypoxiaGO:0001666960.011
cell growthGO:00160491600.011
positive regulation of cell migrationGO:00303351720.011
ribonucleoside monophosphate catabolic processGO:00091581580.011
organophosphate biosynthetic processGO:00904071630.011
neurotransmitter secretionGO:000726940.011
thymus developmentGO:004853830.011
dna catabolic processGO:0006308490.011
regulation of protein localizationGO:00328802960.011
monovalent inorganic cation transportGO:00156721280.011
microtubule cytoskeleton organizationGO:00002261760.011
cellular component disassemblyGO:0022411920.011
memoryGO:000761330.010
regulation of dephosphorylationGO:0035303960.010
regulation of sequence specific dna binding transcription factor activityGO:00510902110.010
regulation of i kappab kinase nf kappab signalingGO:00431221620.010
mitotic nuclear divisionGO:00070671190.010
positive regulation of cell motilityGO:20001471770.010
actin cytoskeleton organizationGO:00300362070.010
cellular response to radiationGO:0071478650.010
regulation of multi organism processGO:00439001570.010
response to peptide hormoneGO:0043434610.010
associative learningGO:000830610.010
myeloid cell differentiationGO:00300991170.010
ribonucleotide biosynthetic processGO:0009260810.010
heart developmentGO:0007507950.010
regulation of viral processGO:00507921030.010
positive regulation of secretion by cellGO:19035321080.010
positive regulation of protein phosphorylationGO:00019343130.010
dna geometric changeGO:0032392320.010
dna catabolic process exonucleolyticGO:0000738170.010
muscle contractionGO:0006936730.010
regulation of ras gtpase activityGO:00323181280.010
lipid localizationGO:00108761060.010
negative regulation of intracellular signal transductionGO:19025321830.010
cell projection assemblyGO:00300311260.010
endomembrane system organizationGO:00102561960.010
positive regulation of cell adhesionGO:0045785840.010
regulation of hormone levelsGO:00108171250.010
response to lipidGO:00339932060.010
peripheral nervous system developmentGO:000742220.010
reactive nitrogen species metabolic processGO:200105730.010
rhythmic behaviorGO:000762220.010

APLF disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
primary immunodeficiency diseaseDOID:612360.902
immune system diseaseDOID:29141550.902
disease of cellular proliferationDOID:145661740.480
combined t cell and b cell immunodeficiencyDOID:628120.402
cancerDOID:1621670.344
organ system cancerDOID:00506861640.344
hematologic cancerDOID:2531360.240
immune system cancerDOID:0060083360.240
bone marrow cancerDOID:4960100.240
myelomaDOID:007000470.240
brain diseaseDOID:936730.080
neonatal period electroclinical syndromeDOID:0050702190.080
electroclinical syndromeDOID:0050701320.080
central nervous system diseaseDOID:3311860.080
epilepsy syndromeDOID:1826410.080
nervous system diseaseDOID:8634310.080
disease of metabolismDOID:00146672950.029
sensory system diseaseDOID:00501552030.021
inherited metabolic disorderDOID:6552420.019
eye diseaseDOID:56141490.017
eye and adnexa diseaseDOID:14921500.017
idiopathic generalized epilepsyDOID:1827210.016
retinal diseaseDOID:56791180.016
neurodegenerative diseaseDOID:12891020.011
amino acid metabolic disorderDOID:9252500.011
musculoskeletal system diseaseDOID:172230.011