Homo sapiens

0 known processes

HSD17B3

hydroxysteroid (17-beta) dehydrogenase 3

(Aliases: SDR12C2,EDH17B3)

HSD17B3 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular ketone metabolic processGO:0042180800.139
cellular amino acid metabolic processGO:00065201160.136
amine metabolic processGO:0009308440.104
system processGO:00030083490.099
cellular amine metabolic processGO:0044106410.097
regulation of cellular amino acid metabolic processGO:000652160.094
regulation of cellular ketone metabolic processGO:0010565500.091
positive regulation of cellular amine metabolic processGO:003324070.090
regulation of cellular amine metabolic processGO:0033238110.087
cellular response to endogenous stimulusGO:00714953360.077
positive regulation of cellular amino acid metabolic processGO:004576430.077
cation transportGO:00068123310.077
g protein coupled receptor signaling pathwayGO:00071862070.072
anion transportGO:00068201610.071
chemical homeostasisGO:00488783060.062
secretionGO:00469032540.058
defense responseGO:00069523150.058
post embryonic developmentGO:000979120.057
immune responseGO:00069553070.056
response to oxygen containing compoundGO:19017003690.054
positive regulation of transportGO:00510503360.054
cellular cation homeostasisGO:00300031630.053
negative regulation of cell deathGO:00605483450.051
lipid metabolic processGO:00066293810.050
cellular homeostasisGO:00197251960.050
regulation of hormone levelsGO:00108171250.048
ion homeostasisGO:00508012300.048
enzyme linked receptor protein signaling pathwayGO:00071673030.048
ion transmembrane transportGO:00342203380.047
transmembrane transportGO:00550853990.047
metal ion transportGO:00300012720.046
blood circulationGO:00080151130.045
cation transmembrane transportGO:00986552380.044
cellular lipid metabolic processGO:00442553030.043
regenerationGO:003109940.043
multicellular organismal agingGO:001025930.042
Worm
cation homeostasisGO:00550801890.042
small molecule biosynthetic processGO:00442831570.042
negative regulation of protein metabolic processGO:00512483910.041
response to organic cyclic compoundGO:00140702040.041
female gamete generationGO:000729220.041
positive regulation of phosphorylationGO:00423273940.040
cellular chemical homeostasisGO:00550821800.040
ras protein signal transductionGO:0007265730.038
cellular calcium ion homeostasisGO:00068741170.038
regulation of cellular component movementGO:00512703340.038
single organism cellular localizationGO:19025803320.038
response to biotic stimulusGO:00096072760.037
regulation of secretionGO:00510461940.037
lipid biosynthetic processGO:00086101770.037
cytokine productionGO:00018162470.037
cytoplasmic transportGO:00164823790.037
nucleotide catabolic processGO:00091664080.037
determination of adult lifespanGO:000834020.036
Worm
organic anion transportGO:00157111030.036
metal ion homeostasisGO:00550651690.036
small gtpase mediated signal transductionGO:0007264780.035
regulation of nucleotide metabolic processGO:00061402690.035
positive regulation of hydrolase activityGO:00513453310.035
inorganic ion transmembrane transportGO:00986602310.035
negative regulation of catalytic activityGO:00430863350.034
cellular metal ion homeostasisGO:00068751460.034
single organism membrane organizationGO:00448022680.034
response to cytokineGO:00340972320.034
response to abiotic stimulusGO:00096283360.034
response to lipidGO:00339932060.034
cellular ion homeostasisGO:00068731680.033
purine ribonucleoside metabolic processGO:00461284370.033
nucleoside triphosphate metabolic processGO:00091414220.033
cellular response to oxygen containing compoundGO:19017012760.033
oogenesisGO:004847720.033
nucleoside catabolic processGO:00091644080.032
negative regulation of programmed cell deathGO:00430693210.032
regulation of transferase activityGO:00513383550.032
oxidation reduction processGO:00551143960.032
organonitrogen compound biosynthetic processGO:19015662000.032
negative regulation of cellular protein metabolic processGO:00322693530.032
divalent inorganic cation homeostasisGO:00725071360.031
positive regulation of cellular component organizationGO:00511303760.031
positive regulation of developmental processGO:00510943140.031
positive regulation of nucleotide metabolic processGO:00459812300.031
negative regulation of phosphorus metabolic processGO:00105632670.030
membrane organizationGO:00610242920.030
locomotory behaviorGO:000762610.030
cell projection organizationGO:00300302520.030
biological adhesionGO:00226103310.030
cellular response to growth factor stimulusGO:00713631970.030
neurological system processGO:00508771630.030
cellular divalent inorganic cation homeostasisGO:00725031280.030
protein localization to organelleGO:00333652800.029
response to external biotic stimulusGO:00432072610.029
divalent metal ion transportGO:00708381520.029
regulation of cell differentiationGO:00455953930.029
regulation of cell cycleGO:00517263930.029
purine ribonucleotide catabolic processGO:00091544040.029
regulation of ion transportGO:00432691890.029
positive regulation of cell proliferationGO:00082843010.029
regulation of kinase activityGO:00435493140.029
cell developmentGO:00484683280.028
regulation of response to external stimulusGO:00321012220.028
inorganic cation transmembrane transportGO:00986621940.028
glycosyl compound catabolic processGO:19016584130.028
response to other organismGO:00517072610.028
circulatory system processGO:00030131130.028
response to woundingGO:00096111680.028
purine containing compound catabolic processGO:00725234110.028
organophosphate biosynthetic processGO:00904071630.028
cell adhesionGO:00071553250.027
regulation of purine nucleotide metabolic processGO:19005422640.027
nitrogen compound transportGO:00717051910.027
negative regulation of transportGO:00510511760.027
protein oligomerizationGO:00512591730.027
regulation of cytokine productionGO:00018172320.027
secretion by cellGO:00329402260.027
ribonucleoside catabolic processGO:00424544060.027
vesicle mediated transportGO:00161923710.027
purine nucleoside catabolic processGO:00061523980.027
negative regulation of cellular component organizationGO:00511292350.027
positive regulation of protein phosphorylationGO:00019343130.027
regulation of secretion by cellGO:19035301770.027
response to nitrogen compoundGO:19016981840.027
response to growth factorGO:00708482050.027
organophosphate catabolic processGO:00464344300.026
rho protein signal transductionGO:0007266260.026
regulation of establishment of protein localizationGO:00702012420.026
regulation of cell migrationGO:00303342890.026
regulation of immune responseGO:00507762010.026
protein catabolic processGO:00301633250.026
protein maturationGO:00516042330.026
apoptotic signaling pathwayGO:00971902680.026
negative regulation of phosphate metabolic processGO:00459362670.026
memoryGO:000761330.026
ribonucleoside triphosphate catabolic processGO:00092033910.026
response to hormoneGO:00097251750.026
signal transduction by phosphorylationGO:00230142970.026
regulation of protein localizationGO:00328802960.026
purine ribonucleoside catabolic processGO:00461303980.025
positive regulation of purine nucleotide metabolic processGO:19005442270.025
regulation of protein transportGO:00512232130.025
regulation of cell motilityGO:20001452990.025
mitotic cell cycleGO:00002783260.025
purine ribonucleoside triphosphate metabolic processGO:00092054110.025
innate immune responseGO:00450871780.025
cellular component morphogenesisGO:00329893140.025
ribonucleoside triphosphate metabolic processGO:00091994120.025
mitotic cell cycle processGO:19030472860.025
positive regulation of catabolic processGO:00098963100.025
purine nucleotide catabolic processGO:00061954050.025
positive regulation of cytosolic calcium ion concentrationGO:0007204820.025
mapk cascadeGO:00001652880.025
cellular response to cytokine stimulusGO:00713451810.025
cellular response to organic cyclic compoundGO:00714071270.024
regulation of protein kinase activityGO:00458592890.024
regulation of cellular component biogenesisGO:00440872810.024
purine nucleoside triphosphate metabolic processGO:00091444120.024
regulation of locomotionGO:00400123290.024
regulation of mapk cascadeGO:00434082620.024
intracellular protein transportGO:00068862700.024
nucleoside triphosphate catabolic processGO:00091433940.024
protein processingGO:00164852260.024
negative regulation of multicellular organismal processGO:00512413170.024
neuromuscular junction developmentGO:000752830.024
regulation of intracellular transportGO:00323861950.024
wound healingGO:00420601150.023
camp metabolic processGO:0046058610.023
cell morphogenesisGO:00009022960.023
organic hydroxy compound metabolic processGO:19016151470.023
regulation of cell cycle processGO:00105642660.023
purine ribonucleoside triphosphate catabolic processGO:00092073910.023
actin filament based processGO:00300292240.023
calcium ion transportGO:00068161470.023
carbohydrate derivative biosynthetic processGO:19011372070.023
positive regulation of cytokine productionGO:00018191670.023
hormone metabolic processGO:0042445610.022
single organism carbohydrate metabolic processGO:00447231930.022
ribonucleotide catabolic processGO:00092614050.022
regulation of proteolysisGO:00301622930.022
cellular macromolecule catabolic processGO:00442653800.022
cardiac muscle cell contractionGO:008600340.022
nucleoside phosphate biosynthetic processGO:19012931090.022
positive regulation of transferase activityGO:00513472270.022
purine nucleoside triphosphate catabolic processGO:00091463920.022
positive regulation of cell migrationGO:00303351720.022
endomembrane system organizationGO:00102561960.022
divalent inorganic cation transportGO:00725111580.022
positive regulation of cell deathGO:00109422630.022
calcium ion homeostasisGO:00550741220.022
cellular response to nitrogen compoundGO:19016991440.022
regulation of response to woundingGO:19030341010.022
segmentationGO:003528240.022
carbohydrate metabolic processGO:00059752070.022
negative regulation of apoptotic processGO:00430663160.022
steroid metabolic processGO:0008202940.022
cytosolic calcium ion homeostasisGO:0051480890.022
nucleoside phosphate catabolic processGO:19012924120.021
positive regulation of protein kinase activityGO:00458601900.021
muscle system processGO:0003012810.021
maintenance of locationGO:00512351120.021
regulation of purine nucleotide catabolic processGO:00331212050.021
negative regulation of cellular amino acid metabolic processGO:004576320.021
positive regulation of immune system processGO:00026842830.021
guanosine containing compound metabolic processGO:19010682440.021
reactive oxygen species biosynthetic processGO:190340940.021
regulation of growthGO:00400081650.021
nucleotide biosynthetic processGO:00091651090.021
positive regulation of cellular catabolic processGO:00313312840.021
purine ribonucleotide biosynthetic processGO:0009152790.020
sensory perceptionGO:00076001030.020
carboxylic acid biosynthetic processGO:0046394970.020
organic hydroxy compound transportGO:0015850630.020
cellular macromolecular complex assemblyGO:00346223240.020
organic acid biosynthetic processGO:0016053970.020
regulation of small gtpase mediated signal transductionGO:00510561560.020
regulation of anatomical structure morphogenesisGO:00226032860.020
spermatid differentiationGO:004851540.020
9 cis retinoic acid metabolic processGO:004290510.020
growthGO:00400072020.020
angiogenesisGO:00015251470.020
cellular response to hormone stimulusGO:00328701250.019
positive regulation of cell differentiationGO:00455972110.019
peptidyl tyrosine phosphorylationGO:00181081700.019
blood vessel morphogenesisGO:00485141620.019
protein targetingGO:00066051870.019
cyclic nucleotide metabolic processGO:0009187820.019
nervous system developmentGO:00073992930.019
anatomical structure formation involved in morphogenesisGO:00486462840.019
positive regulation of apoptotic processGO:00430652460.019
reactive oxygen species metabolic processGO:0072593750.019
response to inorganic substanceGO:00100351270.019
peptidyl tyrosine modificationGO:00182121700.019
regulation of transmembrane transportGO:00347621390.019
glycine importGO:003623310.019
positive regulation of hormone biosynthetic processGO:004688640.019
peripheral nervous system developmentGO:000742220.019
regulation of cyclic nucleotide metabolic processGO:0030799630.019
regulation of nucleoside metabolic processGO:00091182090.019
salivary gland morphogenesisGO:000743540.019
muscle contractionGO:0006936730.019
positive regulation of cell motilityGO:20001471770.019
purine nucleotide biosynthetic processGO:0006164840.019
detection of stimulusGO:0051606850.019
guanosine containing compound catabolic processGO:19010692390.019
neuron projection regenerationGO:003110210.019
cell activationGO:00017752130.019
positive regulation of programmed cell deathGO:00430682490.019
regulation of nucleotide catabolic processGO:00308112050.018
negative regulation of hydrolase activityGO:00513461820.018
regulation of ras protein signal transductionGO:00465781550.018
gtp metabolic processGO:00460392390.018
protein modification by small protein conjugationGO:00324463420.018
regulation of endopeptidase activityGO:00525481700.018
positive regulation of kinase activityGO:00336742040.018
response to organonitrogen compoundGO:00102431560.018
ribose phosphate biosynthetic processGO:0046390820.018
circulatory system developmentGO:00723592620.018
negative regulation of protein modification processGO:00314002000.018
cellular protein catabolic processGO:00442572610.018
immune effector processGO:00022521590.018
sensory perception of painGO:001923340.018
positive regulation of mapk cascadeGO:00434101900.018
negative regulation of developmental processGO:00510932470.018
reactive nitrogen species metabolic processGO:200105730.018
cell growthGO:00160491600.018
positive regulation of purine nucleotide biosynthetic processGO:1900373380.018
limbic system developmentGO:002176130.018
regulation of metal ion transportGO:00109591200.018
tissue regenerationGO:004224630.018
regulation of membrane potentialGO:0042391950.017
cyclic purine nucleotide metabolic processGO:0052652600.017
dephosphorylationGO:00163112090.017
morphogenesis of embryonic epitheliumGO:001633140.017
regulation of cellular response to stressGO:00801352440.017
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.017
rhythmic behaviorGO:000762220.017
gtp catabolic processGO:00061842370.017
fatty acid metabolic processGO:00066311150.017
regulation of gtp catabolic processGO:00331241800.017
negative regulation of cellular amine metabolic processGO:003323930.017
positive regulation of nucleotide catabolic processGO:00308131850.017
regulation of protein serine threonine kinase activityGO:00719001790.017
establishment of protein localization to organelleGO:00725941720.017
regulation of ion transmembrane transportGO:00347651320.017
regulation of protein maturationGO:19033171500.017
monocarboxylic acid metabolic processGO:00327871850.017
response to axon injuryGO:004867810.017
posttranscriptional regulation of gene expressionGO:00106082130.017
spermatid developmentGO:000728640.017
circadian behaviorGO:004851220.017
organelle assemblyGO:00709251760.017
multicellular organismal homeostasisGO:0048871670.017
positive regulation of ion transportGO:0043270870.017
negative regulation of cell differentiationGO:00455961710.017
mitochondrion organizationGO:00070051560.017
protein localization to membraneGO:00726571600.017
regulation of cytoplasmic transportGO:19036491490.017
alcohol metabolic processGO:00060661140.017
astrocyte differentiationGO:004870840.017
regulation of synaptic plasticityGO:004816730.017
protein ubiquitinationGO:00165673140.017
oocyte developmentGO:004859910.016
ribonucleotide biosynthetic processGO:0009260810.016
negative regulation of protein maturationGO:19033181420.016
regulation of camp metabolic processGO:0030814520.016
positive regulation of synaptic transmissionGO:005080640.016
glycerolipid metabolic processGO:00464861070.016
wnt signaling pathwayGO:00160551560.016
negative regulation of cell cycleGO:00457861930.016
blastoderm segmentationGO:000735020.016
cardiac muscle contractionGO:0060048340.016
chemotaxisGO:00069351570.016
regulation of peptidase activityGO:00525471800.016
purine containing compound biosynthetic processGO:0072522880.016
anatomical structure homeostasisGO:00602491000.016
positive regulation of nucleoside metabolic processGO:00459791860.016
nuclear transportGO:00511691790.016
regulation of multi organism processGO:00439001570.016
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.016
organic acid transportGO:0015849650.016
cellular response to dna damage stimulusGO:00069743790.016
negative regulation of intracellular signal transductionGO:19025321830.016
negative regulation of phosphorylationGO:00423261740.016
epithelium developmentGO:00604292270.016
positive regulation of steroid hormone biosynthetic processGO:009003120.016
regulation of wound healingGO:0061041560.016
coagulationGO:0050817780.016
regulation of protein catabolic processGO:00421761550.016
cgmp catabolic processGO:004606930.016
negative regulation of proteolysisGO:00458611320.016
histone modificationGO:00165702510.015
regulation of homeostatic processGO:00328441210.015
negative regulation of secretionGO:0051048580.015
sequestering of metal ionGO:0051238240.015
motor neuron axon guidanceGO:000804520.015
cellular response to organonitrogen compoundGO:00714171240.015
regulation of reactive oxygen species biosynthetic processGO:190342630.015
regulation of cell adhesionGO:00301551660.015
regulation of body fluid levelsGO:0050878990.015
chromatin organizationGO:00063253510.015
camp biosynthetic processGO:0006171470.015
epithelial cell proliferationGO:00506731280.015
regulation of protein processingGO:00706131500.015
nucleocytoplasmic transportGO:00069131760.015
positive regulation of purine nucleotide catabolic processGO:00331231850.015
cellular response to lipidGO:00713961270.015
regulation of ras gtpase activityGO:00323181280.015
angiotensin activated signaling pathwayGO:003816640.015
epoxygenase p450 pathwayGO:001937330.015
sensory perception of light stimulusGO:0050953350.015
interspecies interaction between organismsGO:00444191560.015
neurogenesisGO:00220081690.015
proteolysis involved in cellular protein catabolic processGO:00516032440.015
regulation of apoptotic signaling pathwayGO:20012331750.015
cardiovascular system developmentGO:00723582620.015
positive regulation of immune responseGO:00507781590.015
associative learningGO:000830610.015
cyclic nucleotide biosynthetic processGO:0009190610.015
cofactor metabolic processGO:0051186870.015
monovalent inorganic cation transportGO:00156721280.015
negative regulation of protein processingGO:00109551420.015
response to disaccharideGO:003428510.015
anterior posterior axis specificationGO:000994820.015
neuroblast proliferationGO:000740540.015
receptor metabolic processGO:0043112810.015
negative regulation of cell proliferationGO:00082852280.015
oocyte differentiationGO:000999420.015
positive regulation of cyclic nucleotide metabolic processGO:0030801490.015
cell part morphogenesisGO:00329901370.015
cell substrate adhesionGO:00315891320.015
actin cytoskeleton organizationGO:00300362070.015
striated muscle contractionGO:0006941520.015
response to radiationGO:00093141510.015
positive regulation of cellular component movementGO:00512721810.015
tissue homeostasisGO:0001894630.015
positive regulation of organelle organizationGO:00106381950.015
positive regulation of aldosterone metabolic processGO:003234620.015
synaptic transmission glycinergicGO:006001210.014
regulation of cell morphogenesisGO:00226041530.014
covalent chromatin modificationGO:00165692540.014
defense response to other organismGO:00985421290.014
microtubule based processGO:00070172100.014
carboxylic acid transportGO:0046942630.014
anterior posterior axis specification embryoGO:000859520.014
monocarboxylic acid biosynthetic processGO:0072330670.014
regulation of protein complex assemblyGO:00432541470.014
lung alveolus developmentGO:004828640.014
cellular protein complex assemblyGO:00436231880.014
cellular response to disaccharide stimulusGO:007132410.014
glycerophospholipid metabolic processGO:0006650840.014
negative regulation of synaptic transmissionGO:005080520.014
regulation of mitotic cell cycleGO:00073461890.014
vasculature developmentGO:00019441810.014
lipid transportGO:0006869900.014
regulation of male gonad developmentGO:200001840.014
protein homooligomerizationGO:00512601000.014
glycoprotein metabolic processGO:00091001100.014
epithelial cell differentiationGO:00308551410.014
positive regulation of gtpase activityGO:00435471660.014
activation of protein kinase activityGO:0032147900.014
tripartite regional subdivisionGO:000735120.014
regulation of endothelial cell differentiationGO:004560140.014
response to corticotropin releasing hormoneGO:004343510.014
negative regulation of voltage gated calcium channel activityGO:190138640.014
activation of immune responseGO:00022531140.014
micturitionGO:006007330.014
inner ear morphogenesisGO:004247240.014
compound eye developmentGO:004874910.014
regulation of cell projection organizationGO:00313441070.014
response to fungusGO:000962040.014
regulation of sequence specific dna binding transcription factor activityGO:00510902110.014
cell divisionGO:00513011680.014
cell projection assemblyGO:00300311260.014
multi organism cellular processGO:00447641560.014
epidermal growth factor activated receptor transactivation by g protein coupled receptor signaling pathwayGO:003562540.014
positive regulation of cyclic nucleotide biosynthetic processGO:0030804380.014
regulation of purine nucleotide biosynthetic processGO:1900371500.013
phospholipid metabolic processGO:0006644990.013
positive regulation of cellular component biogenesisGO:00440891580.013
second messenger mediated signalingGO:0019932780.013
protein secretionGO:0009306980.013
regulation of system processGO:00440571010.013
regulation of cell developmentGO:00602841610.013
regulation of meiotic cell cycleGO:005144540.013
cell cycle phase transitionGO:00447701730.013
regulation of cell growthGO:00015581350.013
cell fate determinationGO:000170930.013
lens development in camera type eyeGO:000208820.013
immune system developmentGO:00025201950.013
positive regulation of peptidyl tyrosine phosphorylationGO:0050731850.013
negative regulation of organelle organizationGO:00106391260.013
protein importGO:00170381300.013
positive regulation of organic acid transportGO:003289230.013
lipid localizationGO:00108761060.013
protein autophosphorylationGO:00467771230.013
blood coagulationGO:0007596760.013
plasma membrane organizationGO:00070091150.013
embryonic epithelial tube formationGO:000183840.013
glycine transportGO:001581630.013
sulfur compound metabolic processGO:00067901010.013
photoreceptor cell differentiationGO:004653020.013
positive regulation of secretionGO:00510471160.013
multicellular organismal response to stressGO:003355510.013
regulation of defense responseGO:00313471540.013
purine ribonucleoside monophosphate metabolic processGO:00091671860.013
regulation of cytoskeleton organizationGO:00514931770.013
negative regulation of acetylcholine gated cation channel activityGO:190304910.013
positive regulation of ras gtpase activityGO:00323201170.013
adult locomotory behaviorGO:000834410.013
cell cell signalingGO:00072671550.013
regulation of neural precursor cell proliferationGO:200017740.013
vasodilationGO:004231140.013
small molecule catabolic processGO:0044282920.013
positive regulation of gtp catabolic processGO:00331261660.013
negative regulation of response to woundingGO:1903035470.013
i kappab kinase nf kappab signalingGO:00072491660.013
behavioral response to ethanolGO:004814920.013
response to bacteriumGO:00096171440.013
mitotic cell cycle phase transitionGO:00447721620.013
taxisGO:00423301570.013
lipid catabolic processGO:0016042840.013
regulation of dna metabolic processGO:00510521530.013
sex determinationGO:000753030.013
response to activityGO:001482300.013
regulation of gtpase activityGO:00430871800.013
axon regenerationGO:003110310.013
regulation of intracellular protein transportGO:00331571230.013
positive regulation of reactive oxygen species biosynthetic processGO:190342820.013
regulation of transporter activityGO:0032409820.013
negative regulation of response to external stimulusGO:0032102830.013
cell projection morphogenesisGO:00488581290.012
regulation of protein secretionGO:0050708860.012
embryonic forelimb morphogenesisGO:003511540.012
response to drugGO:0042493810.012
proteasomal protein catabolic processGO:00104981760.012

HSD17B3 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.075
nervous system diseaseDOID:8634310.058
sensory system diseaseDOID:00501552030.058
inherited metabolic disorderDOID:6552420.051
musculoskeletal system diseaseDOID:172230.036
eye and adnexa diseaseDOID:14921500.032
eye diseaseDOID:56141490.031
central nervous system diseaseDOID:3311860.028
retinal diseaseDOID:56791180.027
disease of cellular proliferationDOID:145661740.024
connective tissue diseaseDOID:651090.024
bone diseaseDOID:0080001880.024
immune system diseaseDOID:29141550.022
cancerDOID:1621670.021
organ system cancerDOID:00506861640.021
neurodegenerative diseaseDOID:12891020.016
retinal degenerationDOID:8466890.016
muscular diseaseDOID:00800001140.013
muscle tissue diseaseDOID:661130.013
cardiovascular system diseaseDOID:12871060.013