Homo sapiens

17 known processes

BACE1

beta-site APP-cleaving enzyme 1

(Aliases: KIAA1149,HSPC104,BACE,FLJ90568,ASP2)

BACE1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
post embryonic developmentGO:000979120.155
regulation of cellular amino acid metabolic processGO:000652160.145
amine metabolic processGO:0009308440.143
cellular amino acid metabolic processGO:00065201160.125
locomotory behaviorGO:000762610.124
regulation of cellular amine metabolic processGO:0033238110.121
matingGO:000761810.085
cellular ketone metabolic processGO:0042180800.085
cellular amine metabolic processGO:0044106410.082
regulation of cell differentiationGO:00455953930.079
membrane organizationGO:00610242920.076
neuromuscular junction developmentGO:000752830.076
collateral sproutingGO:004866820.074
axon cargo transportGO:000808820.072
adult locomotory behaviorGO:000834410.070
enzyme linked receptor protein signaling pathwayGO:00071673030.069
memoryGO:000761330.068
cell projection organizationGO:00300302520.067
vesicle mediated transportGO:00161923710.065
regulation of cellular ketone metabolic processGO:0010565500.064
negative regulation of catalytic activityGO:00430863350.063
associative learningGO:000830610.063
negative regulation of protein metabolic processGO:00512483910.062
Human
positive regulation of cellular amine metabolic processGO:003324070.061
regulation of transferase activityGO:00513383550.060
system processGO:00030083490.060
visual learningGO:000854210.059
lipid metabolic processGO:00066293810.057
protein maturationGO:00516042330.057
protein processingGO:00164852260.056
positive regulation of hydrolase activityGO:00513453310.055
response to axon injuryGO:004867810.053
negative regulation of cellular component organizationGO:00511292350.052
purine ribonucleoside metabolic processGO:00461284370.051
positive regulation of cellular component organizationGO:00511303760.050
negative regulation of multicellular organismal processGO:00512413170.050
cellular ion homeostasisGO:00068731680.050
positive regulation of transportGO:00510503360.049
positive regulation of protein phosphorylationGO:00019343130.049
positive regulation of cellular amino acid metabolic processGO:004576430.048
metal ion homeostasisGO:00550651690.048
nervous system developmentGO:00073992930.048
peripheral nervous system developmentGO:000742220.047
negative regulation of hydrolase activityGO:00513461820.047
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.047
negative regulation of cellular protein metabolic processGO:00322693530.047
multicellular organismal agingGO:001025930.046
determination of adult lifespanGO:000834020.046
regulation of synaptic plasticityGO:004816730.046
regulation of protein maturationGO:19033171500.045
regulation of proteolysisGO:00301622930.045
cell developmentGO:00484683280.044
alcohol metabolic processGO:00060661140.044
defense responseGO:00069523150.044
purine ribonucleoside triphosphate metabolic processGO:00092054110.044
secretionGO:00469032540.044
regulation of peptidase activityGO:00525471800.044
cellular component morphogenesisGO:00329893140.043
single organism membrane organizationGO:00448022680.043
visual behaviorGO:000763220.043
regenerationGO:003109940.042
positive regulation of apoptotic processGO:00430652460.040
regulation of protein localizationGO:00328802960.040
protein catabolic processGO:00301633250.040
cellular cation homeostasisGO:00300031630.040
ion transmembrane transportGO:00342203380.040
segmentationGO:003528240.040
regulation of locomotionGO:00400123290.039
regulation of protein kinase activityGO:00458592890.039
regulation of kinase activityGO:00435493140.039
organic anion transportGO:00157111030.038
regulation of cell migrationGO:00303342890.038
positive regulation of protein kinase activityGO:00458601900.038
regulation of cell developmentGO:00602841610.037
regulation of endopeptidase activityGO:00525481700.037
microtubule based processGO:00070172100.037
negative regulation of endopeptidase activityGO:0010951840.037
carbohydrate derivative biosynthetic processGO:19011372070.037
Human
neuron remodelingGO:001632220.037
calcium ion homeostasisGO:00550741220.036
immune responseGO:00069553070.036
negative regulation of peptidase activityGO:0010466910.036
cation homeostasisGO:00550801890.036
neuron differentiationGO:00301821380.036
organic hydroxy compound metabolic processGO:19016151470.036
organophosphate catabolic processGO:00464344300.036
positive regulation of catabolic processGO:00098963100.035
cellular homeostasisGO:00197251960.035
protein localization to membraneGO:00726571600.035
steroid metabolic processGO:0008202940.035
cellular metal ion homeostasisGO:00068751460.035
epithelium developmentGO:00604292270.035
generation of neuronsGO:00486991520.035
regulation of cell motilityGO:20001452990.035
cellular macromolecular complex assemblyGO:00346223240.034
neurological system processGO:00508771630.034
nucleotide catabolic processGO:00091664080.034
regulation of establishment of protein localizationGO:00702012420.034
single organism cellular localizationGO:19025803320.034
neurotransmitter secretionGO:000726940.034
apoptotic signaling pathwayGO:00971902680.033
small gtpase mediated signal transductionGO:0007264780.033
cell morphogenesisGO:00009022960.033
cellular response to dna damage stimulusGO:00069743790.033
negative regulation of protein maturationGO:19033181420.033
regulation of protein processingGO:00706131500.033
purine ribonucleoside catabolic processGO:00461303980.033
negative regulation of protein processingGO:00109551420.032
endomembrane system organizationGO:00102561960.032
cerebral cortex cell migrationGO:002179530.032
nucleoside phosphate catabolic processGO:19012924120.032
purine containing compound catabolic processGO:00725234110.032
signal transduction by phosphorylationGO:00230142970.032
cardiovascular system developmentGO:00723582620.031
secretion by cellGO:00329402260.031
organophosphate biosynthetic processGO:00904071630.031
nucleoside triphosphate metabolic processGO:00091414220.030
chemical homeostasisGO:00488783060.030
divalent inorganic cation homeostasisGO:00725071360.030
negative regulation of phosphorus metabolic processGO:00105632670.030
taxisGO:00423301570.030
negative regulation of apoptotic processGO:00430663160.030
cellular protein complex assemblyGO:00436231880.030
negative regulation of proteolysisGO:00458611320.030
nucleoside triphosphate catabolic processGO:00091433940.030
positive regulation of cell deathGO:00109422630.029
purine nucleoside catabolic processGO:00061523980.029
negative regulation of cell deathGO:00605483450.029
rna processingGO:00063962550.029
positive regulation of programmed cell deathGO:00430682490.029
positive regulation of transferase activityGO:00513472270.029
purine nucleoside triphosphate catabolic processGO:00091463920.029
ras protein signal transductionGO:0007265730.029
plasma membrane organizationGO:00070091150.029
response to external biotic stimulusGO:00432072610.029
behaviorGO:00076101120.028
response to oxygen containing compoundGO:19017003690.028
positive regulation of cellular catabolic processGO:00313312840.028
regulation of cell cycleGO:00517263930.028
neurogenesisGO:00220081690.028
negative regulation of cellular amino acid metabolic processGO:004576320.027
glial cell migrationGO:000834740.027
chemotaxisGO:00069351570.027
purine nucleoside triphosphate metabolic processGO:00091444120.027
growthGO:00400072020.027
convergent extensionGO:006002610.027
purine ribonucleoside triphosphate catabolic processGO:00092073910.027
neuron developmentGO:00486661130.027
negative regulation of programmed cell deathGO:00430693210.026
cellular protein catabolic processGO:00442572610.026
positive regulation of developmental processGO:00510943140.026
response to abiotic stimulusGO:00096283360.026
ribonucleotide catabolic processGO:00092614050.026
carbohydrate metabolic processGO:00059752070.026
mitotic cell cycleGO:00002783260.026
biological adhesionGO:00226103310.026
cell morphogenesis involved in differentiationGO:00009041440.026
posttranscriptional regulation of gene expressionGO:00106082130.026
female gamete generationGO:000729220.026
positive regulation of peptidase activityGO:0010952880.025
cell part morphogenesisGO:00329901370.025
vasculature developmentGO:00019441810.025
regulation of neuron differentiationGO:0045664700.025
cellular macromolecule catabolic processGO:00442653800.025
positive regulation of proteolysisGO:00458621420.025
cytoplasmic transportGO:00164823790.025
regulation of cellular component biogenesisGO:00440872810.025
response to biotic stimulusGO:00096072760.025
regulation of ion transportGO:00432691890.025
purine ribonucleotide catabolic processGO:00091544040.024
blastoderm segmentationGO:000735020.024
negative regulation of locomotionGO:00400131180.024
gtp catabolic processGO:00061842370.024
regulation of immune responseGO:00507762010.024
oogenesisGO:004847720.024
small molecule biosynthetic processGO:00442831570.024
regulation of nervous system developmentGO:0051960880.024
neuron projection developmentGO:00311751060.024
cell projection morphogenesisGO:00488581290.024
protein acylationGO:00435431380.024
positive regulation of immune system processGO:00026842830.024
translationGO:00064121320.024
regulation of sequence specific dna binding transcription factor activityGO:00510902110.023
ionotropic glutamate receptor signaling pathwayGO:0035235160.023
regulation of protein transportGO:00512232130.023
chromatin organizationGO:00063253510.023
regulation of response to external stimulusGO:00321012220.023
actin filament based processGO:00300292240.023
single organism carbohydrate metabolic processGO:00447231930.023
protein acetylationGO:00064731160.023
response to other organismGO:00517072610.023
negative regulation of protein modification processGO:00314002000.023
negative regulation of intracellular signal transductionGO:19025321830.023
response to growth factorGO:00708482050.022
cellular chemical homeostasisGO:00550821800.022
purine nucleotide catabolic processGO:00061954050.022
innate immune responseGO:00450871780.022
positive regulation of organelle organizationGO:00106381950.022
cell cycle arrestGO:0007050710.022
copper ion homeostasisGO:005507030.022
retinal ganglion cell axon guidanceGO:003129020.022
chromatin modificationGO:00165682980.022
protein localization to plasma membraneGO:0072659930.022
positive regulation of protein serine threonine kinase activityGO:00719021190.022
ribonucleoside monophosphate metabolic processGO:00091611870.022
ion homeostasisGO:00508012300.022
negative regulation of developmental processGO:00510932470.022
positive regulation of phosphorylationGO:00423273940.022
regulation of nucleotide metabolic processGO:00061402690.021
reactive oxygen species metabolic processGO:0072593750.021
positive regulation of secretionGO:00510471160.021
regulation of anatomical structure morphogenesisGO:00226032860.021
glycosyl compound catabolic processGO:19016584130.021
ribonucleoside triphosphate catabolic processGO:00092033910.021
maintenance of locationGO:00512351120.021
histone modificationGO:00165702510.021
inorganic ion transmembrane transportGO:00986602310.021
cellular divalent inorganic cation homeostasisGO:00725031280.021
neuron projection regenerationGO:003110210.021
protein localization to organelleGO:00333652800.021
inorganic cation transmembrane transportGO:00986621940.021
endocytosisGO:00068971590.021
cytokine productionGO:00018162470.020
covalent chromatin modificationGO:00165692540.020
positive regulation of cellular component biogenesisGO:00440891580.020
single organism cell adhesionGO:00986021790.020
ribonucleoside catabolic processGO:00424544060.020
cell cycle phase transitionGO:00447701730.020
guanosine containing compound catabolic processGO:19010692390.020
cellular calcium ion homeostasisGO:00068741170.020
regulation of neurogenesisGO:0050767820.020
regulation of cytoskeleton organizationGO:00514931770.020
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.020
mapk cascadeGO:00001652880.020
negative regulation of phosphorylationGO:00423261740.020
regulation of growthGO:00400081650.020
actin cytoskeleton organizationGO:00300362070.020
positive regulation of cell motilityGO:20001471770.020
axon regenerationGO:003110310.020
organonitrogen compound biosynthetic processGO:19015662000.020
regulation of protein serine threonine kinase activityGO:00719001790.020
mitotic cell cycle processGO:19030472860.019
regulation of bindingGO:00510981110.019
circadian behaviorGO:004851220.019
hindbrain developmentGO:003090230.019
rhythmic behaviorGO:000762220.019
proteolysis involved in cellular protein catabolic processGO:00516032440.019
protein oligomerizationGO:00512591730.019
positive regulation of protein transportGO:00512221350.019
positive regulation of cell migrationGO:00303351720.019
negative regulation of cellular amine metabolic processGO:003323930.019
regulation of mapk cascadeGO:00434082620.019
negative regulation of cell developmentGO:0010721480.019
cellular response to oxygen containing compoundGO:19017012760.019
regulation of cell cycle phase transitionGO:19019871260.019
peptidyl lysine modificationGO:00182051440.019
anterior posterior axis specificationGO:000994820.019
spermatid differentiationGO:004851540.019
regulation of nucleotide catabolic processGO:00308112050.019
regulation of protein catabolic processGO:00421761550.018
regulation of mitotic cell cycle phase transitionGO:19019901180.018
regulation of purine nucleotide metabolic processGO:19005422640.018
internal protein amino acid acetylationGO:00064751010.018
ubiquitin dependent protein catabolic processGO:00065112060.018
cellular lipid metabolic processGO:00442553030.018
response to woundingGO:00096111680.018
g2 m transition of mitotic cell cycleGO:0000086410.018
cell adhesionGO:00071553250.018
regulation of protein complex assemblyGO:00432541470.018
regulation of purine nucleotide catabolic processGO:00331212050.018
cholesterol metabolic processGO:0008203280.018
nucleoside catabolic processGO:00091644080.018
organelle assemblyGO:00709251760.018
regulation of cell morphogenesisGO:00226041530.018
receptor metabolic processGO:0043112810.018
monocarboxylic acid metabolic processGO:00327871850.018
positive regulation of immune responseGO:00507781590.018
extrinsic apoptotic signaling pathwayGO:00971911190.018
nucleoside monophosphate metabolic processGO:00091231910.018
positive regulation of nucleotide metabolic processGO:00459812300.018
oocyte differentiationGO:000999420.018
cation transportGO:00068123310.018
regulation of cell growthGO:00015581350.018
positive regulation of reactive oxygen species metabolic processGO:2000379240.018
sequestering of metal ionGO:0051238240.018
nucleotide biosynthetic processGO:00091651090.018
response to oxidative stressGO:00069791210.018
epidermis morphogenesisGO:004873030.018
rho protein signal transductionGO:0007266260.018
regulation of protein bindingGO:0043393660.017
positive regulation of purine nucleotide metabolic processGO:19005442270.017
positive regulation of mitotic cell cycleGO:0045931600.017
regulation of ras protein signal transductionGO:00465781550.017
regulation of metal ion transportGO:00109591200.017
nucleoside phosphate biosynthetic processGO:19012931090.017
dephosphorylationGO:00163112090.017
cell growthGO:00160491600.017
phospholipid metabolic processGO:0006644990.017
neuronal action potentialGO:001922890.017
cytoskeleton dependent intracellular transportGO:0030705210.017
peptidyl lysine acetylationGO:00183941010.017
spermatid developmentGO:000728640.017
cell type specific apoptotic processGO:00972851250.017
microtubule based movementGO:0007018320.017
ribonucleoside triphosphate metabolic processGO:00091994120.017
mrna processingGO:00063971330.017
endosomal transportGO:00161971290.017
organic acid transportGO:0015849650.017
positive regulation of ras gtpase activityGO:00323201170.017
peptidyl tyrosine modificationGO:00182121700.017
actin filament based movementGO:0030048170.017
negative regulation of neuron differentiationGO:0045665210.017
purine ribonucleotide biosynthetic processGO:0009152790.016
purine nucleoside monophosphate metabolic processGO:00091261860.016
regulation of cell cycle processGO:00105642660.016
synaptic vesicle endocytosisGO:004848820.016
motor neuron axon guidanceGO:000804520.016
cell cycle g2 m phase transitionGO:0044839430.016
regulation of nucleoside metabolic processGO:00091182090.016
regulation of defense responseGO:00313471540.016
positive regulation of cellular component movementGO:00512721810.016
regulation of meiotic cell cycleGO:005144540.016
negative regulation of synaptic transmissionGO:005080520.016
positive regulation of nucleotide catabolic processGO:00308131850.016
transition metal ion homeostasisGO:0055076310.016
peptidyl tyrosine phosphorylationGO:00181081700.016
establishment of protein localization to membraneGO:00901501210.016
positive regulation of secretion by cellGO:19035321080.016
response to cytokineGO:00340972320.016
cell activationGO:00017752130.016
negative regulation of immune system processGO:00026831360.016
dna repairGO:00062811980.016
cell cell signalingGO:00072671550.016
response to radiationGO:00093141510.016
reactive oxygen species biosynthetic processGO:190340940.016
cerebral cortex radially oriented cell migrationGO:002179910.016
cell divisionGO:00513011680.016
anatomical structure formation involved in morphogenesisGO:00486462840.016
regulation of neuronal synaptic plasticityGO:004816810.016
atp metabolic processGO:00460341760.016
spinal cord developmentGO:002151040.016
anterior posterior axis specification embryoGO:000859520.016
regulation of protein secretionGO:0050708860.016
nuclear transportGO:00511691790.016
angiogenesisGO:00015251470.016
morphogenesis of a polarized epitheliumGO:000173830.016
positive regulation of nucleoside metabolic processGO:00459791860.016
regulation of vesicle mediated transportGO:00606271300.015
organ formationGO:004864530.015
modification dependent macromolecule catabolic processGO:00436322120.015
modification dependent protein catabolic processGO:00199412090.015
regulation of gtp catabolic processGO:00331241800.015
leukocyte activationGO:00453211640.015
glycoprotein biosynthetic processGO:0009101910.015
Human
positive regulation of cell proliferationGO:00082843010.015
gtp metabolic processGO:00460392390.015
divalent metal ion transportGO:00708381520.015
sulfur compound metabolic processGO:00067901010.015
positive regulation of vasoconstrictionGO:004590730.015
negative regulation of cell differentiationGO:00455961710.015
cell chemotaxisGO:00603261120.015
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.015
oocyte developmentGO:004859910.015
cdc42 protein signal transductionGO:003248840.015
thymus developmentGO:004853830.015
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.015
positive regulation of apoptotic signaling pathwayGO:2001235700.015
symbiosis encompassing mutualism through parasitismGO:00444031560.015
microtubule cytoskeleton organizationGO:00002261760.015
forebrain generation of neuronsGO:002187230.015
sequestering of calcium ionGO:0051208170.015
nitrogen compound transportGO:00717051910.015
regulation of cytoplasmic transportGO:19036491490.015
regulation of i kappab kinase nf kappab signalingGO:00431221620.014
calcium ion transportGO:00068161470.014
protein ubiquitinationGO:00165673140.014
ameboidal type cell migrationGO:00016671350.014
cellular transition metal ion homeostasisGO:0046916210.014
lipid biosynthetic processGO:00086101770.014
amino acid transportGO:0006865280.014
regulation of ras gtpase activityGO:00323181280.014
circulatory system developmentGO:00723592620.014
negative regulation of phosphate metabolic processGO:00459362670.014
reactive nitrogen species metabolic processGO:200105730.014
limbic system developmentGO:002176130.014
regulation of mitotic cell cycleGO:00073461890.014
cation transmembrane transportGO:00986552380.014
immune effector processGO:00022521590.014
brain morphogenesisGO:004885410.014
central nervous system developmentGO:00074171230.014
tissue morphogenesisGO:0048729960.014
positive regulation of axon extensionGO:004577340.014
regulation of neural precursor cell proliferationGO:200017740.014
sleepGO:003043120.014
inner ear morphogenesisGO:004247240.014
glycoprotein metabolic processGO:00091001100.014
Human
negative regulation of cellular component movementGO:00512711060.014
mitotic cell cycle phase transitionGO:00447721620.014
negative regulation of cell migrationGO:00303361020.014
single organismal cell cell adhesionGO:00163371480.014
metencephalon developmentGO:002203720.014
positive regulation of cell cycleGO:00457871400.014
activation of immune responseGO:00022531140.014
purine ribonucleoside monophosphate metabolic processGO:00091671860.014
action potentialGO:0001508340.013
actin mediated cell contractionGO:0070252120.013
synaptic transmissionGO:0007268610.013
regulation of epithelial cell migrationGO:0010632930.013
rna 3 end processingGO:0031123350.013
ribose phosphate biosynthetic processGO:0046390820.013
guanosine containing compound metabolic processGO:19010682440.013
embryo developmentGO:00097901230.013
regulation of glial cell differentiationGO:004568530.013
positive regulation of cytosolic calcium ion concentrationGO:0007204820.013
tissue regenerationGO:004224630.013
interspecies interaction between organismsGO:00444191560.013
positive regulation of reactive oxygen species biosynthetic processGO:190342820.013
stem cell divisionGO:001714520.013
negative regulation of axonogenesisGO:005077140.013
epithelial cell migrationGO:00106311190.013
positive regulation of gtpase activityGO:00435471660.013
glycosylationGO:0070085710.013
negative regulation of neurogenesisGO:0050768260.013
regulation of cellular component movementGO:00512703340.013
multi organism cellular processGO:00447641560.013
carboxylic acid biosynthetic processGO:0046394970.013
positive regulation of purine nucleotide catabolic processGO:00331231850.013
divalent inorganic cation transportGO:00725111580.013
purine nucleotide biosynthetic processGO:0006164840.013
cell fate determinationGO:000170930.013
regulation of axon guidanceGO:190266730.013
proteasomal protein catabolic processGO:00104981760.013
negative regulation of response to external stimulusGO:0032102830.013
neuron apoptotic processGO:0051402390.013
regulation of cellular response to stressGO:00801352440.013
exocytosisGO:0006887710.013
neuron deathGO:0070997650.013
embryonic epithelial tube formationGO:000183840.013
skeletal system developmentGO:0001501790.013
establishment of planar polarityGO:000173630.012
cellular response to cytokine stimulusGO:00713451810.012
somitogenesisGO:000175620.012
positive regulation of cytokine productionGO:00018191670.012
regulation of cell adhesionGO:00301551660.012
intracellular protein transportGO:00068862700.012
sensory perception of smellGO:000760820.012
sensory perceptionGO:00076001030.012
hemopoiesisGO:00300971800.012
positive regulation of locomotionGO:00400171860.012
tripartite regional subdivisionGO:000735120.012
metal ion transportGO:00300012720.012
regulation of secretion by cellGO:19035301770.012
regulation of translationGO:0006417890.012
regulation of neurotransmitter secretionGO:004692830.012
transmembrane transportGO:00550853990.012
muscle cell fate commitmentGO:004269340.012
long term synaptic potentiationGO:006029110.012
synaptic vesicle recyclingGO:003646530.012
positive regulation of g2 m transition of mitotic cell cycleGO:001097180.012
morphogenesis of embryonic epitheliumGO:001633140.012
regulation of actin cytoskeleton organizationGO:00329561160.012
oxidation reduction processGO:00551143960.012
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.012
organic acid biosynthetic processGO:0016053970.012
neuron projection morphogenesisGO:0048812500.012

BACE1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
acquired metabolic diseaseDOID:0060158580.128
disease of metabolismDOID:00146672950.128
disease of mental healthDOID:150700.118
cognitive disorderDOID:1561290.118
central nervous system diseaseDOID:3311860.112
nervous system diseaseDOID:8634310.112
neurodegenerative diseaseDOID:12891020.048
tauopathyDOID:680160.048
musculoskeletal system diseaseDOID:172230.033
sensory system diseaseDOID:00501552030.029
alzheimer s diseaseDOID:10652160.027
dementiaDOID:1307190.027
inherited metabolic disorderDOID:6552420.027
eye and adnexa diseaseDOID:14921500.026
brain diseaseDOID:936730.023
eye diseaseDOID:56141490.021
cardiovascular system diseaseDOID:12871060.021
muscular diseaseDOID:00800001140.020
muscle tissue diseaseDOID:661130.020
myopathyDOID:4231040.020
connective tissue diseaseDOID:651090.017
bone diseaseDOID:0080001880.017
retinal diseaseDOID:56791180.016
disease of cellular proliferationDOID:145661740.016
cancerDOID:1621670.016
retinal degenerationDOID:8466890.015
heart diseaseDOID:114680.013
organ system cancerDOID:00506861640.013