Homo sapiens

51 known processes

BACE2

beta-site APP-cleaving enzyme 2

(Aliases: ASP21,DRAP,BAE2,CEAP1,ALP56,AEPLC,ASP1)

BACE2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular amino acid metabolic processGO:00065201160.102
post embryonic developmentGO:000979120.095
regulation of cellular amine metabolic processGO:0033238110.090
regulation of cellular amino acid metabolic processGO:000652160.084
cellular amine metabolic processGO:0044106410.082
amine metabolic processGO:0009308440.075
regulation of cellular ketone metabolic processGO:0010565500.071
cellular ketone metabolic processGO:0042180800.068
positive regulation of cellular amino acid metabolic processGO:004576430.054
regulation of locomotionGO:00400123290.053
positive regulation of cellular component organizationGO:00511303760.051
regulation of cellular component movementGO:00512703340.050
positive regulation of cellular amine metabolic processGO:003324070.048
cell adhesionGO:00071553250.046
biological adhesionGO:00226103310.045
multicellular organismal agingGO:001025930.043
determination of adult lifespanGO:000834020.041
epithelium developmentGO:00604292270.040
response to oxygen containing compoundGO:19017003690.040
negative regulation of cell deathGO:00605483450.039
regulation of protein localizationGO:00328802960.039
negative regulation of protein metabolic processGO:00512483910.039
negative regulation of cellular protein metabolic processGO:00322693530.039
regulation of cell migrationGO:00303342890.038
positive regulation of hydrolase activityGO:00513453310.037
cation transportGO:00068123310.037
regulation of cell differentiationGO:00455953930.036
positive regulation of phosphorylationGO:00423273940.036
negative regulation of catalytic activityGO:00430863350.036
positive regulation of transportGO:00510503360.036
negative regulation of multicellular organismal processGO:00512413170.036
regulation of cell motilityGO:20001452990.036
immune responseGO:00069553070.035
defense responseGO:00069523150.034
response to abiotic stimulusGO:00096283360.034
cell developmentGO:00484683280.034
cellular response to endogenous stimulusGO:00714953360.034
female gamete generationGO:000729220.034
regulation of proteolysisGO:00301622930.033
cardiovascular system developmentGO:00723582620.033
positive regulation of protein phosphorylationGO:00019343130.033
vesicle mediated transportGO:00161923710.033
secretionGO:00469032540.032
negative regulation of apoptotic processGO:00430663160.032
cellular response to oxygen containing compoundGO:19017012760.032
cytoplasmic transportGO:00164823790.031
ion transmembrane transportGO:00342203380.031
positive regulation of developmental processGO:00510943140.031
positive regulation of immune system processGO:00026842830.031
single organism cell adhesionGO:00986021790.031
locomotory behaviorGO:000762610.030
regulation of protein kinase activityGO:00458592890.030
response to lipidGO:00339932060.030
positive regulation of cell deathGO:00109422630.030
apoptotic signaling pathwayGO:00971902680.030
morphogenesis of embryonic epitheliumGO:001633140.030
cell morphogenesisGO:00009022960.030
mapk cascadeGO:00001652880.030
ras protein signal transductionGO:0007265730.029
actin filament based processGO:00300292240.029
purine containing compound catabolic processGO:00725234110.029
regulation of establishment of protein localizationGO:00702012420.029
negative regulation of programmed cell deathGO:00430693210.029
purine ribonucleoside catabolic processGO:00461303980.029
secretion by cellGO:00329402260.029
cellular component morphogenesisGO:00329893140.029
positive regulation of apoptotic processGO:00430652460.029
positive regulation of programmed cell deathGO:00430682490.029
negative regulation of phosphate metabolic processGO:00459362670.029
single organism cellular localizationGO:19025803320.029
oogenesisGO:004847720.028
intracellular protein transportGO:00068862700.028
protein maturationGO:00516042330.028
purine ribonucleoside metabolic processGO:00461284370.028
response to biotic stimulusGO:00096072760.028
negative regulation of cell proliferationGO:00082852280.028
anion transportGO:00068201610.028
signal transduction by phosphorylationGO:00230142970.028
ribonucleoside triphosphate metabolic processGO:00091994120.028
carbohydrate metabolic processGO:00059752070.028
positive regulation of cell migrationGO:00303351720.027
regulation of peptidase activityGO:00525471800.027
anatomical structure formation involved in morphogenesisGO:00486462840.027
organophosphate catabolic processGO:00464344300.027
regulation of cellular component biogenesisGO:00440872810.027
nucleoside phosphate catabolic processGO:19012924120.027
glycosyl compound catabolic processGO:19016584130.027
regulation of cytokine productionGO:00018172320.027
single organism membrane organizationGO:00448022680.027
membrane organizationGO:00610242920.027
positive regulation of locomotionGO:00400171860.027
purine nucleoside triphosphate metabolic processGO:00091444120.027
ribonucleoside catabolic processGO:00424544060.027
lipid metabolic processGO:00066293810.027
cell projection organizationGO:00300302520.027
enzyme linked receptor protein signaling pathwayGO:00071673030.027
positive regulation of cell proliferationGO:00082843010.027
regulation of cell cycleGO:00517263930.027
regulation of protein transportGO:00512232130.026
nucleoside triphosphate catabolic processGO:00091433940.026
nucleoside triphosphate metabolic processGO:00091414220.026
negative regulation of phosphorus metabolic processGO:00105632670.026
transmembrane transportGO:00550853990.026
purine nucleotide catabolic processGO:00061954050.026
protein processingGO:00164852260.026
purine nucleoside catabolic processGO:00061523980.026
nervous system developmentGO:00073992930.026
protein catabolic processGO:00301633250.026
single organism carbohydrate metabolic processGO:00447231930.025
ribonucleoside triphosphate catabolic processGO:00092033910.025
system processGO:00030083490.025
regulation of anatomical structure morphogenesisGO:00226032860.025
response to other organismGO:00517072610.025
purine nucleoside triphosphate catabolic processGO:00091463920.025
nucleotide catabolic processGO:00091664080.025
purine ribonucleoside triphosphate metabolic processGO:00092054110.025
chemical homeostasisGO:00488783060.025
purine ribonucleoside triphosphate catabolic processGO:00092073910.025
protein localization to organelleGO:00333652800.025
positive regulation of cellular component movementGO:00512721810.025
segmentationGO:003528240.025
positive regulation of catabolic processGO:00098963100.024
positive regulation of transferase activityGO:00513472270.024
positive regulation of cell motilityGO:20001471770.024
purine ribonucleotide catabolic processGO:00091544040.024
cellular lipid metabolic processGO:00442553030.024
regulation of transferase activityGO:00513383550.024
cytokine productionGO:00018162470.024
circulatory system developmentGO:00723592620.024
neuromuscular junction developmentGO:000752830.024
innate immune responseGO:00450871780.024
regulation of cell adhesionGO:00301551660.024
carbohydrate derivative biosynthetic processGO:19011372070.024
oxidation reduction processGO:00551143960.024
positive regulation of cell differentiationGO:00455972110.024
nucleoside catabolic processGO:00091644080.023
cellular response to dna damage stimulusGO:00069743790.023
regulation of kinase activityGO:00435493140.023
single organismal cell cell adhesionGO:00163371480.023
rho protein signal transductionGO:0007266260.023
regulation of mapk cascadeGO:00434082620.023
negative regulation of developmental processGO:00510932470.023
response to external biotic stimulusGO:00432072610.023
peptidyl tyrosine phosphorylationGO:00181081700.023
cellular macromolecule catabolic processGO:00442653800.023
organonitrogen compound biosynthetic processGO:19015662000.023
small gtpase mediated signal transductionGO:0007264780.023
regenerationGO:003109940.023
negative regulation of hydrolase activityGO:00513461820.022
regulation of purine nucleotide metabolic processGO:19005422640.022
regulation of cellular response to stressGO:00801352440.022
positive regulation of protein kinase activityGO:00458601900.022
ribonucleotide catabolic processGO:00092614050.022
positive regulation of mapk cascadeGO:00434101900.022
regulation of response to external stimulusGO:00321012220.021
regulation of endopeptidase activityGO:00525481700.021
negative regulation of transportGO:00510511760.021
glycoprotein metabolic processGO:00091001100.021
ion homeostasisGO:00508012300.021
embryonic epithelial tube formationGO:000183840.021
memoryGO:000761330.021
cellular macromolecular complex assemblyGO:00346223240.021
negative regulation of intracellular signal transductionGO:19025321830.021
regulation of secretionGO:00510461940.021
negative regulation of protein modification processGO:00314002000.021
metal ion transportGO:00300012720.020
nitrogen compound transportGO:00717051910.020
cell substrate adhesionGO:00315891320.020
regulation of nucleotide metabolic processGO:00061402690.020
mitotic cell cycleGO:00002783260.020
growthGO:00400072020.020
protein modification by small protein conjugationGO:00324463420.020
response to growth factorGO:00708482050.020
blastoderm segmentationGO:000735020.020
blood vessel morphogenesisGO:00485141620.020
negative regulation of cellular amine metabolic processGO:003323930.020
positive regulation of kinase activityGO:00336742040.020
epithelial cell differentiationGO:00308551410.020
positive regulation of cellular catabolic processGO:00313312840.020
regulation of sequence specific dna binding transcription factor activityGO:00510902110.019
regulation of growthGO:00400081650.019
cell activationGO:00017752130.019
negative regulation of cellular amino acid metabolic processGO:004576320.019
positive regulation of cellular component biogenesisGO:00440891580.019
regulation of secretion by cellGO:19035301770.019
protein targetingGO:00066051870.019
actin cytoskeleton organizationGO:00300362070.019
regulation of cell cycle processGO:00105642660.019
regulation of apoptotic signaling pathwayGO:20012331750.019
regulation of immune responseGO:00507762010.019
negative regulation of cellular component organizationGO:00511292350.019
positive regulation of cytokine productionGO:00018191670.019
cellular response to growth factor stimulusGO:00713631970.019
mitotic cell cycle processGO:19030472860.019
protein ubiquitinationGO:00165673140.019
regulation of cell growthGO:00015581350.019
regulation of defense responseGO:00313471540.018
response to cytokineGO:00340972320.018
endomembrane system organizationGO:00102561960.018
lipid biosynthetic processGO:00086101770.018
monocarboxylic acid metabolic processGO:00327871850.018
gtp metabolic processGO:00460392390.018
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.018
regulation of intracellular transportGO:00323861950.018
guanosine containing compound metabolic processGO:19010682440.018
cell growthGO:00160491600.018
positive regulation of organelle organizationGO:00106381950.018
neurological system processGO:00508771630.018
rhythmic behaviorGO:000762220.018
regulation of protein processingGO:00706131500.018
regulation of protein maturationGO:19033171500.018
nuclear transportGO:00511691790.018
cell fate determinationGO:000170930.018
anterior posterior axis specificationGO:000994820.018
organ morphogenesisGO:00098871470.018
salivary gland morphogenesisGO:000743540.018
posttranscriptional regulation of gene expressionGO:00106082130.017
cellular response to cytokine stimulusGO:00713451810.017
negative regulation of cell cycleGO:00457861930.017
protein oligomerizationGO:00512591730.017
response to woundingGO:00096111680.017
chromatin organizationGO:00063253510.017
hemopoiesisGO:00300971800.017
maintenance of locationGO:00512351120.017
positive regulation of purine nucleotide metabolic processGO:19005442270.017
small molecule biosynthetic processGO:00442831570.017
dephosphorylationGO:00163112090.017
regulation of protein catabolic processGO:00421761550.017
chromatin modificationGO:00165682980.017
regulation of epithelial cell migrationGO:0010632930.017
inner ear morphogenesisGO:004247240.017
response to bacteriumGO:00096171440.017
hematopoietic or lymphoid organ developmentGO:00485341860.017
cation transmembrane transportGO:00986552380.017
oocyte developmentGO:004859910.017
guanosine containing compound catabolic processGO:19010692390.017
vasculature developmentGO:00019441810.016
cellular response to lipidGO:00713961270.016
regulation of cell developmentGO:00602841610.016
histone modificationGO:00165702510.016
peptidyl tyrosine modificationGO:00182121700.016
cellular protein catabolic processGO:00442572610.016
negative regulation of proteolysisGO:00458611320.016
negative regulation of cell differentiationGO:00455961710.016
regulation of multi organism processGO:00439001570.016
somatic stem cell maintenanceGO:003501940.016
positive regulation of nucleotide metabolic processGO:00459812300.016
cell type specific apoptotic processGO:00972851250.016
adult locomotory behaviorGO:000834410.016
reactive oxygen species metabolic processGO:0072593750.016
photoreceptor cell differentiationGO:004653020.016
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.016
hindbrain developmentGO:003090230.016
spermatid differentiationGO:004851540.016
regulation of cytoskeleton organizationGO:00514931770.016
regulation of synaptic plasticityGO:004816730.016
regulation of vesicle mediated transportGO:00606271300.016
circadian behaviorGO:004851220.016
wnt signaling pathwayGO:00160551560.016
negative regulation of cell migrationGO:00303361020.016
immune system developmentGO:00025201950.016
positive regulation of secretionGO:00510471160.016
cellular homeostasisGO:00197251960.016
regulation of nucleoside metabolic processGO:00091182090.016
positive regulation of proteolysisGO:00458621420.016
inorganic ion transmembrane transportGO:00986602310.016
oocyte differentiationGO:000999420.016
regulation of purine nucleotide catabolic processGO:00331212050.016
epithelial cell proliferationGO:00506731280.016
positive regulation of immune responseGO:00507781590.015
gtp catabolic processGO:00061842370.015
chemotaxisGO:00069351570.015
inorganic cation transmembrane transportGO:00986621940.015
matingGO:000761810.015
cellular protein complex assemblyGO:00436231880.015
pituitary gland developmentGO:002198320.015
organic anion transportGO:00157111030.015
cation homeostasisGO:00550801890.015
regulation of wnt signaling pathwayGO:00301111230.015
negative regulation of protein processingGO:00109551420.015
regulation of protein serine threonine kinase activityGO:00719001790.015
ameboidal type cell migrationGO:00016671350.015
organophosphate biosynthetic processGO:00904071630.015
leukocyte activationGO:00453211640.015
regulation of mitotic cell cycleGO:00073461890.015
sex determinationGO:000753030.015
regulation of nucleotide catabolic processGO:00308112050.015
protein localization to membraneGO:00726571600.015
interspecies interaction between organismsGO:00444191560.015
nucleocytoplasmic transportGO:00069131760.015
response to nitrogen compoundGO:19016981840.015
establishment of protein localization to organelleGO:00725941720.015
proteolysis involved in cellular protein catabolic processGO:00516032440.015
muscle system processGO:0003012810.015
negative regulation of phosphorylationGO:00423261740.015
covalent chromatin modificationGO:00165692540.015
morphogenesis of a polarized epitheliumGO:000173830.015
positive regulation of synaptic transmissionGO:005080640.015
cell projection assemblyGO:00300311260.015
response to axon injuryGO:004867810.015
epithelial cell migrationGO:00106311190.015
anterior posterior axis specification embryoGO:000859520.015
neural tube formationGO:000184130.015
spermatid developmentGO:000728640.015
blood vessel developmentGO:00015681720.014
response to organic cyclic compoundGO:00140702040.014
organic acid biosynthetic processGO:0016053970.014
carboxylic acid biosynthetic processGO:0046394970.014
glycoprotein biosynthetic processGO:0009101910.014
regulation of cysteine type endopeptidase activityGO:20001161270.014
epithelium migrationGO:00901321190.014
metal ion homeostasisGO:00550651690.014
reactive oxygen species biosynthetic processGO:190340940.014
symbiosis encompassing mutualism through parasitismGO:00444031560.014
negative regulation of immune system processGO:00026831360.014
positive regulation of secretion by cellGO:19035321080.014
regulation of gtpase activityGO:00430871800.014
positive regulation of purine nucleotide catabolic processGO:00331231850.014
negative regulation of cellular component movementGO:00512711060.014
positive regulation of nucleoside metabolic processGO:00459791860.014
regulation of cell morphogenesisGO:00226041530.014
tripartite regional subdivisionGO:000735120.014
regulation of actin filament based processGO:00329701410.014
generation of neuronsGO:00486991520.014
regulation of neural precursor cell proliferationGO:200017740.014
negative regulation of locomotionGO:00400131180.014
compound eye developmentGO:004874910.014
sensory perception of smellGO:000760820.014
regulation of intracellular protein transportGO:00331571230.014
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.014
negative regulation of protein maturationGO:19033181420.014
regulation of gtp catabolic processGO:00331241800.014
muscle contractionGO:0006936730.014
motor neuron axon guidanceGO:000804520.014
regulation of protein complex assemblyGO:00432541470.014
cell cycle phase transitionGO:00447701730.014
canonical wnt signaling pathwayGO:00600701160.014
syncytium formation by plasma membrane fusionGO:000076820.014
cellular chemical homeostasisGO:00550821800.013
positive regulation of nucleotide catabolic processGO:00308131850.013
regulation of vasculature developmentGO:1901342970.013
primary neural tube formationGO:001402030.013
microtubule based processGO:00070172100.013
response to inorganic substanceGO:00100351270.013
actin mediated cell contractionGO:0070252120.013
protein localization to nucleusGO:00345041360.013
positive regulation of protein transportGO:00512221350.013
cell divisionGO:00513011680.013
regulation of cytoplasmic transportGO:19036491490.013
regulation of cell activationGO:00508651250.013
cellular metal ion homeostasisGO:00068751460.013
response to hormoneGO:00097251750.013
cardiac muscle cell contractionGO:008600340.013
i kappab kinase nf kappab signalingGO:00072491660.013
divalent inorganic cation transportGO:00725111580.013
angiogenesisGO:00015251470.013
proteasomal protein catabolic processGO:00104981760.013
ribonucleoside monophosphate metabolic processGO:00091611870.013
neural crest cell developmentGO:001403230.013
post embryonic organ developmentGO:004856910.013
viral processGO:00160321460.013
organelle assemblyGO:00709251760.013
regulation of bindingGO:00510981110.013
ubiquitin dependent protein catabolic processGO:00065112060.013
modification dependent macromolecule catabolic processGO:00436322120.013
epidermis morphogenesisGO:004873030.013
cell chemotaxisGO:00603261120.013
tube developmentGO:00352951250.013
leukocyte migrationGO:00509001070.013
organ formationGO:004864530.013
regulation of canonical wnt signaling pathwayGO:0060828880.013
negative regulation of protein phosphorylationGO:00019331400.013
reactive nitrogen species metabolic processGO:200105730.013
regulation of ion transportGO:00432691890.013
calcium ion transportGO:00068161470.013
purine ribonucleoside monophosphate metabolic processGO:00091671860.013
neurogenesisGO:00220081690.013
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.013
tube closureGO:006060630.013
peripheral nervous system developmentGO:000742220.013
cellular cation homeostasisGO:00300031630.013
neuron projection regenerationGO:003110210.013
regulation of leukocyte activationGO:00026941150.013
peptidyl lysine modificationGO:00182051440.013
extrinsic apoptotic signaling pathwayGO:00971911190.012
myoblast fusionGO:000752010.012
nucleoside monophosphate metabolic processGO:00091231910.012
associative learningGO:000830610.012
sensory perceptionGO:00076001030.012
tissue regenerationGO:004224630.012
neurotransmitter secretionGO:000726940.012
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.012
regulation of peptidyl tyrosine phosphorylationGO:00507301080.012
purine nucleoside monophosphate metabolic processGO:00091261860.012
establishment of protein localization to membraneGO:00901501210.012
central nervous system developmentGO:00074171230.012
regulation of reactive oxygen species biosynthetic processGO:190342630.012
regulation of epithelial cell proliferationGO:00506781130.012
modification dependent protein catabolic processGO:00199412090.012
cell morphogenesis involved in differentiationGO:00009041440.012
atp metabolic processGO:00460341760.012
regulation of dna metabolic processGO:00510521530.012
intrinsic apoptotic signaling pathwayGO:00971931270.012
actin filament based movementGO:0030048170.012
regulation of ras protein signal transductionGO:00465781550.012
neuron developmentGO:00486661130.012
endocytosisGO:00068971590.012
protein acylationGO:00435431380.012
stress activated mapk cascadeGO:0051403930.012
release of cytoplasmic sequestered nf kappabGO:000858840.012
inflammatory responseGO:0006954790.012
regulation of small gtpase mediated signal transductionGO:00510561560.012
establishment of tissue polarityGO:000716430.012
positive regulation of gtpase activityGO:00435471660.012
limbic system developmentGO:002176130.012
response to radiationGO:00093141510.012
negative regulation of peptidase activityGO:0010466910.012
response to transforming growth factor betaGO:0071559940.012
regulation of i kappab kinase nf kappab signalingGO:00431221620.012
retina vasculature morphogenesis in camera type eyeGO:006129930.012
multi organism cellular processGO:00447641560.012
cardiac muscle contractionGO:0060048340.012
regulation of meiotic cell cycleGO:005144540.012
actin filament organizationGO:00070151280.012
visual behaviorGO:000763220.012
establishment of planar polarityGO:000173630.012
divalent metal ion transportGO:00708381520.012
negative regulation of cell motilityGO:20001461040.012
endosomal transportGO:00161971290.012
organic hydroxy compound metabolic processGO:19016151470.012
cellular response to abiotic stimulusGO:00712141170.012
neural tube closureGO:000184330.012
positive regulation of cell cycleGO:00457871400.012
positive regulation of gtp catabolic processGO:00331261660.012
metencephalon developmentGO:002203720.012
immune effector processGO:00022521590.012
cellular response to transforming growth factor beta stimulusGO:0071560940.012
mitochondrion organizationGO:00070051560.012
neuron differentiationGO:00301821380.012
monocarboxylic acid biosynthetic processGO:0072330670.012
plasma membrane organizationGO:00070091150.012
endodermal cell fate commitmentGO:000171140.012
lymphocyte activationGO:00466491330.012
response to organonitrogen compoundGO:00102431560.012
spinal cord developmentGO:002151040.012
regulation of response to woundingGO:19030341010.012
taxisGO:00423301570.011
endodermal cell fate specificationGO:000171440.011
negative regulation of organelle organizationGO:00106391260.011
neuroblast proliferationGO:000740540.011
cerebral cortex cell migrationGO:002179530.011
negative regulation of growthGO:0045926970.011
regulation of hormone levelsGO:00108171250.011
tissue migrationGO:00901301190.011
developmental programmed cell deathGO:001062330.011
mitotic cell cycle phase transitionGO:00447721620.011
epithelial tube branching involved in lung morphogenesisGO:006044140.011
cell part morphogenesisGO:00329901370.011
protein autophosphorylationGO:00467771230.011
rna interferenceGO:001624640.011
regulation of cell cycle phase transitionGO:19019871260.011
cell projection morphogenesisGO:00488581290.011
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.011
regulation of ras gtpase activityGO:00323181280.011
response to fungusGO:000962040.011
embryo developmentGO:00097901230.011
lipid transportGO:0006869900.011
cellular response to nitrogen compoundGO:19016991440.011
negative regulation of gliogenesisGO:001401430.011
t cell differentiation in thymusGO:003307740.011

BACE2 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:172230.048
disease of metabolismDOID:00146672950.034
connective tissue diseaseDOID:651090.025
sensory system diseaseDOID:00501552030.024
nervous system diseaseDOID:8634310.024
inherited metabolic disorderDOID:6552420.023
bone diseaseDOID:0080001880.022
eye and adnexa diseaseDOID:14921500.021
eye diseaseDOID:56141490.021
central nervous system diseaseDOID:3311860.021
disease of cellular proliferationDOID:145661740.020
cancerDOID:1621670.020
organ system cancerDOID:00506861640.020
retinal diseaseDOID:56791180.016
immune system diseaseDOID:29141550.014
bone development diseaseDOID:0080006550.013
cardiovascular system diseaseDOID:12871060.013
muscle tissue diseaseDOID:661130.012
muscular diseaseDOID:00800001140.012
neurodegenerative diseaseDOID:12891020.012
myopathyDOID:4231040.012
retinal degenerationDOID:8466890.012
brain diseaseDOID:936730.011