Homo sapiens

40 known processes

PSEN2

presenilin 2 (Alzheimer disease 4)

(Aliases: CMD1V,PS2,AD3L,STM2,AD4)

PSEN2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
calcium ion transmembrane transportGO:0070588760.997
Human
negative regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic processGO:200005930.983
Mouse
cation transmembrane transportGO:00986552380.957
Human
amyloid precursor protein catabolic processGO:0042987120.905
brain morphogenesisGO:004885410.903
Mouse
regulation of protein localization to plasma membraneGO:1903076400.884
single organism cell adhesionGO:00986021790.865
Human
negative regulation of cell deathGO:00605483450.855
Human Mouse
single organism membrane organizationGO:00448022680.845
platelet formationGO:003022040.841
positive regulation of protein targeting to membraneGO:009031480.829
positive regulation of transportGO:00510503360.826
cellular calcium ion homeostasisGO:00068741170.815
Human Mouse
platelet morphogenesisGO:003634440.798
cell adhesionGO:00071553250.790
Human
negative regulation of megakaryocyte differentiationGO:0045653160.780
negative regulation of phosphate metabolic processGO:00459362670.776
Mouse
cellular amine metabolic processGO:0044106410.775
inorganic cation transmembrane transportGO:00986621940.744
Human
notch receptor processingGO:000722020.744
cellular response to dna damage stimulusGO:00069743790.732
hair follicle maturationGO:004882030.723
Mouse
divalent metal ion transportGO:00708381520.711
Human Mouse
regulation of establishment of protein localizationGO:00702012420.704
membrane organizationGO:00610242920.692
positive regulation of cellular component organizationGO:00511303760.690
regulation of sequence specific dna binding transcription factor activityGO:00510902110.689
ion transmembrane transportGO:00342203380.684
Human
inorganic ion transmembrane transportGO:00986602310.679
Human
single organism cellular localizationGO:19025803320.675
cardiovascular system developmentGO:00723582620.673
positive regulation of intracellular transportGO:00323881040.659
striated muscle contractionGO:0006941520.659
Mouse
negative regulation of phosphorylationGO:00423261740.630
Mouse
adenylate cyclase modulating g protein coupled receptor signaling pathwayGO:0007188430.618
cellular metal ion homeostasisGO:00068751460.617
Human Mouse
regulation of cellular amino acid metabolic processGO:000652160.608
cellular divalent inorganic cation homeostasisGO:00725031280.607
Human Mouse
biological adhesionGO:00226103310.606
Human
cellular response to nerve growth factor stimulusGO:199009060.592
protein localization to membraneGO:00726571600.587
regulation of protein serine threonine kinase activityGO:00719001790.586
amine metabolic processGO:0009308440.582
associative learningGO:000830610.577
hematopoietic progenitor cell differentiationGO:0002244380.575
Mouse
mapk cascadeGO:00001652880.572
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.555
positive regulation of phosphorylationGO:00423273940.552
signal transduction by phosphorylationGO:00230142970.546
regulation of protein localizationGO:00328802960.545
beta amyloid formationGO:003420570.541
cation homeostasisGO:00550801890.538
Human Mouse
negative regulation of protein metabolic processGO:00512483910.536
Mouse
regulation of microtubule based processGO:0032886740.523
regulation of metalloenzyme activityGO:004855230.519
negative regulation of protein phosphorylationGO:00019331400.517
Mouse
cation transportGO:00068123310.500
Human Mouse
spermatid developmentGO:000728640.500
regulation of protein targetingGO:1903533910.492
negative regulation of cellular component organizationGO:00511292350.489
Mouse
myeloid dendritic cell differentiationGO:004301130.480
regulation of protein catabolic processGO:00421761550.479
Mouse
protein modification by small protein conjugationGO:00324463420.475
Mouse
cell substrate adhesionGO:00315891320.462
regulation of intracellular protein transportGO:00331571230.461
metal ion homeostasisGO:00550651690.457
Human Mouse
positive regulation of secretionGO:00510471160.451
positive regulation of secretion by cellGO:19035321080.449
blood vessel morphogenesisGO:00485141620.443
regulation of cell adhesionGO:00301551660.432
cellular component morphogenesisGO:00329893140.431
positive regulation of cell differentiationGO:00455972110.429
regulation of cell morphogenesis involved in differentiationGO:0010769830.418
chemokine mediated signaling pathwayGO:0070098160.417
hematopoietic or lymphoid organ developmentGO:00485341860.414
Mouse
regulation of megakaryocyte differentiationGO:0045652220.411
substrate adhesion dependent cell spreadingGO:0034446410.410
negative regulation of developmental processGO:00510932470.410
regulation of bindingGO:00510981110.410
Mouse
ion homeostasisGO:00508012300.408
Human Mouse
positive regulation of blood vessel endothelial cell migrationGO:0043536160.402
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.392
Mouse
regulation of microtubule polymerization or depolymerizationGO:0031110270.391
positive regulation of cytosolic calcium ion concentrationGO:0007204820.390
negative regulation of apoptotic signaling pathwayGO:2001234970.387
Mouse
cerebral cortex neuron differentiationGO:002189510.386
positive regulation of proteolysisGO:00458621420.385
Mouse
cellular response to endogenous stimulusGO:00714953360.384
positive regulation of protein serine threonine kinase activityGO:00719021190.383
regulation of microtubule cytoskeleton organizationGO:0070507610.381
regulation of mapk cascadeGO:00434082620.380
positive regulation of organelle organizationGO:00106381950.373
regulation of growthGO:00400081650.371
protein localization to plasma membraneGO:0072659930.371
regulation of cell migration involved in sprouting angiogenesisGO:009004990.364
microtubule cytoskeleton organizationGO:00002261760.363
positive regulation of cell deathGO:00109422630.361
Mouse
vasculature developmentGO:00019441810.359
regulation of cell differentiationGO:00455953930.354
sequestering of calcium ionGO:0051208170.350
positive regulation of kinase activityGO:00336742040.350
positive regulation of nf kappab transcription factor activityGO:0051092810.350
thymus developmentGO:004853830.349
Mouse
negative regulation of microtubule polymerization or depolymerizationGO:0031111170.347
establishment of protein localization to plasma membraneGO:0090002680.344
nitrogen compound transportGO:00717051910.338
cellular homeostasisGO:00197251960.337
Human Mouse
memoryGO:000761330.333
Mouse
negative regulation of neurogenesisGO:0050768260.333
protein ubiquitinationGO:00165673140.332
Mouse
peptide secretionGO:0002790510.331
regulation of cell growthGO:00015581350.330
cardiac muscle cell contractionGO:008600340.327
negative regulation of protein modification processGO:00314002000.324
Mouse
actin filament based processGO:00300292240.321
regulation of intracellular transportGO:00323861950.321
negative regulation of neuron differentiationGO:0045665210.316
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messengerGO:0007187430.313
anatomical structure formation involved in morphogenesisGO:00486462840.310
Mouse
peptidyl tyrosine modificationGO:00182121700.308
Mouse
spermatid differentiationGO:004851540.307
plasma membrane organizationGO:00070091150.305
regulation of protein transportGO:00512232130.304
posttranscriptional regulation of gene expressionGO:00106082130.304
positive regulation of mapk cascadeGO:00434101900.304
positive regulation of calcium ion transport into cytosolGO:0010524200.300
positive regulation of transferase activityGO:00513472270.298
positive regulation of angiogenesisGO:0045766510.294
regulation of insulin secretionGO:0050796330.293
positive regulation of cell adhesion mediated by integrinGO:003363090.292
positive regulation of intracellular protein transportGO:0090316760.292
calcium mediated signalingGO:0019722440.288
peptidyl tyrosine phosphorylationGO:00181081700.286
Mouse
cellular amino acid metabolic processGO:00065201160.285
synaptic vesicle exocytosisGO:001607930.279
negative regulation of cytoskeleton organizationGO:0051494450.278
positive regulation of cell migration involved in sprouting angiogenesisGO:009005030.277
protein targetingGO:00066051870.274
regulation of hematopoietic progenitor cell differentiationGO:1901532240.269
regulation of homeostatic processGO:00328441210.268
muscle system processGO:0003012810.267
Mouse
positive regulation of proteasomal protein catabolic processGO:1901800350.267
Mouse
regulation of apoptotic signaling pathwayGO:20012331750.266
Mouse
negative regulation of ubiquitin protein transferase activityGO:005144480.265
Mouse
sequestering of metal ionGO:0051238240.264
blood vessel endothelial cell migrationGO:0043534420.262
blood vessel developmentGO:00015681720.262
amyloid precursor protein metabolic processGO:0042982170.261
positive regulation of protein phosphorylationGO:00019343130.261
regulation of proteasomal protein catabolic processGO:0061136870.260
Mouse
copper ion importGO:001567710.258
positive regulation of establishment of protein localization to plasma membraneGO:0090004180.258
single organismal cell cell adhesionGO:00163371480.258
Human
motor neuron axon guidanceGO:000804520.256
regulation of cell morphogenesisGO:00226041530.253
beta amyloid metabolic processGO:0050435120.252
Mouse
microtubule depolymerizationGO:0007019180.249
negative regulation of cell projection organizationGO:0031345220.247
regulation of peptide hormone secretionGO:0090276410.247
signal releaseGO:0023061700.244
regulation of purine nucleotide metabolic processGO:19005422640.243
sprouting angiogenesisGO:0002040290.242
positive regulation of endothelial cell migrationGO:0010595390.239
transmembrane transportGO:00550853990.238
Human
circulatory system developmentGO:00723592620.236
protein maturationGO:00516042330.235
ubiquitin dependent protein catabolic processGO:00065112060.232
Mouse
negative regulation of multicellular organismal processGO:00512413170.232
growthGO:00400072020.229
protein importGO:00170381300.226
mitochondrion organizationGO:00070051560.226
regulation of transcription factor import into nucleusGO:0042990390.224
protein catabolic processGO:00301633250.224
Mouse
negative regulation of intracellular signal transductionGO:19025321830.222
negative regulation of neuron projection developmentGO:0010977150.219
regulation of blood vessel endothelial cell migrationGO:0043535300.218
membrane protein proteolysisGO:0033619380.216
cell developmentGO:00484683280.215
regulation of vasculature developmentGO:1901342970.214
regulation of cellular component biogenesisGO:00440872810.214
Mouse
mitotic cell cycleGO:00002783260.212
regulation of cardiac muscle contractionGO:0055117330.211
negative regulation of axonogenesisGO:005077140.208
intracellular protein transportGO:00068862700.207
regulation of transferase activityGO:00513383550.207
Mouse
positive regulation of cell morphogenesis involved in differentiationGO:0010770500.199
g protein coupled receptor signaling pathwayGO:00071862070.196
negative regulation of programmed cell deathGO:00430693210.196
Human Mouse
neuron projection developmentGO:00311751060.195
second messenger mediated signalingGO:0019932780.195
modification dependent macromolecule catabolic processGO:00436322120.193
Mouse
negative regulation of cellular protein metabolic processGO:00322693530.191
Mouse
coagulationGO:0050817780.191
Mouse
cellular response to starvationGO:0009267580.191
cerebral cortex cell migrationGO:002179530.191
visual learningGO:000854210.190
positive regulation of catabolic processGO:00098963100.188
Mouse
positive regulation of cell motilityGO:20001471770.183
inositol phosphate mediated signalingGO:0048016160.183
positive regulation of protein localization to plasma membraneGO:1903078200.181
positive regulation of protein transportGO:00512221350.181
establishment of protein localization to membraneGO:00901501210.181
protein complex disassemblyGO:0043241520.180
regulation of myeloid cell differentiationGO:0045637810.180
immune system developmentGO:00025201950.179
Mouse
protein glycosylationGO:0006486620.178
anion transportGO:00068201610.178
cell activation involved in immune responseGO:0002263300.178
Mouse
cytoplasmic sequestering of proteinGO:0051220120.178
cilium organizationGO:0044782680.177
negative regulation of cell differentiationGO:00455961710.177
secretion by cellGO:00329402260.177
actin crosslink formationGO:005176410.177
regulation of peptidase activityGO:00525471800.177
cell growthGO:00160491600.175
post embryonic developmentGO:000979120.174
glycosylationGO:0070085710.174
regulation of transporter activityGO:0032409820.173
regulation of protein modification by small protein conjugation or removalGO:19033201070.173
Mouse
cell communication by electrical coupling involved in cardiac conductionGO:008606430.168
angiogenesisGO:00015251470.168
positive regulation of protein kinase activityGO:00458601900.167
l glutamate transportGO:001581360.167
negative regulation of apoptotic processGO:00430663160.167
Human Mouse
regulation of cellular component movementGO:00512703340.166
megakaryocyte differentiationGO:0030219250.166
regulation of multi organism processGO:00439001570.166
regulation of neurogenesisGO:0050767820.165
cell matrix adhesionGO:0007160850.165
transcription factor import into nucleusGO:0042991400.165
positive regulation of metalloenzyme activityGO:004855420.164
regulation of anatomical structure morphogenesisGO:00226032860.163
enzyme linked receptor protein signaling pathwayGO:00071673030.160
Mouse
negative regulation of cellular amino acid metabolic processGO:004576320.159
positive regulation of protein catabolic processGO:0045732750.159
Mouse
cell morphogenesisGO:00009022960.158
regulation of hormone levelsGO:00108171250.157
positive regulation of substrate adhesion dependent cell spreadingGO:1900026150.156
negative regulation of phosphorus metabolic processGO:00105632670.156
Mouse
release of sequestered calcium ion into cytosolGO:0051209410.156
positive regulation of proteolysis involved in cellular protein catabolic processGO:1903052350.154
Mouse
regulation of protein ubiquitinationGO:0031396950.154
Mouse
regulation of i kappab kinase nf kappab signalingGO:00431221620.154
positive regulation of cell substrate adhesionGO:0010811370.153
negative regulation of nervous system developmentGO:0051961280.153
positive regulation of cellular catabolic processGO:00313312840.152
Mouse
regulation of cytoskeleton organizationGO:00514931770.151
hemostasisGO:0007599760.150
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434710.149
Mouse
apoptotic mitochondrial changesGO:0008637570.149
positive regulation of ion transportGO:0043270870.147
cellular macromolecule catabolic processGO:00442653800.146
Mouse
microtubule polymerization or depolymerizationGO:0031109370.146
actin mediated cell contractionGO:0070252120.146
ameboidal type cell migrationGO:00016671350.144
positive regulation of reproductive processGO:200024390.144
modification dependent protein catabolic processGO:00199412090.143
Mouse
positive regulation of cell proliferationGO:00082843010.142
regulation of cell projection organizationGO:00313441070.140
regulation of synaptic plasticityGO:004816730.140
Mouse
regulation of protein bindingGO:0043393660.139
Mouse
cellular response to tumor necrosis factorGO:0071356630.138
actin filament based movementGO:0030048170.137
immune response activating cell surface receptor signaling pathwayGO:0002429450.137
Mouse
myeloid cell differentiationGO:00300991170.137
Mouse
negative regulation of hematopoietic progenitor cell differentiationGO:1901533180.137
somitogenesisGO:000175620.136
Mouse
organic acid transportGO:0015849650.136
negative regulation of myeloid cell differentiationGO:0045638420.136
cytosolic calcium ion homeostasisGO:0051480890.134
amide transportGO:0042886760.132
positive regulation of hormone secretionGO:0046887250.131
negative regulation of homeostatic processGO:0032845590.131
cellular response to cytokine stimulusGO:00713451810.130
regulation of calcium ion transport into cytosolGO:0010522330.127
cellular amide metabolic processGO:0043603690.127
Mouse
cellular macromolecular complex assemblyGO:00346223240.127
negative regulation of microtubule depolymerizationGO:0007026120.127
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.126
Mouse
organelle assemblyGO:00709251760.125
response to tumor necrosis factorGO:0034612760.125
positive regulation of programmed cell deathGO:00430682490.123
Mouse
maintenance of location in cellGO:0051651620.123
intrinsic apoptotic signaling pathwayGO:00971931270.122
hormone secretionGO:0046879650.122
protein ubiquitination involved in ubiquitin dependent protein catabolic processGO:0042787370.122
Mouse
single organism carbohydrate metabolic processGO:00447231930.121
negative regulation of bindingGO:0051100570.120
Mouse
protein depolymerizationGO:0051261300.118
epithelium migrationGO:00901321190.118
ribonucleoside monophosphate metabolic processGO:00091611870.117
regulation of peptidyl tyrosine phosphorylationGO:00507301080.117
Mouse
immune responseGO:00069553070.117
Mouse
leukocyte activation involved in immune responseGO:0002366300.116
Mouse
mitochondrial transportGO:0006839600.115
hemopoiesisGO:00300971800.114
Mouse
regulation of cell adhesion mediated by integrinGO:0033628220.114
positive regulation of release of sequestered calcium ion into cytosolGO:0051281160.113
positive regulation of epithelial cell migrationGO:0010634550.112
positive regulation of multi organism processGO:0043902560.112
negative regulation of extrinsic apoptotic signaling pathwayGO:2001237520.112
Mouse
chemical homeostasisGO:00488783060.112
Human Mouse
carbohydrate derivative biosynthetic processGO:19011372070.110
regulation of calcium mediated signalingGO:0050848170.109
negative regulation of organelle organizationGO:00106391260.109
proteolysis involved in cellular protein catabolic processGO:00516032440.109
Mouse
cytokine mediated signaling pathwayGO:00192211090.107
regulation of proteolysisGO:00301622930.107
Mouse
secretionGO:00469032540.107
microtubule based processGO:00070172100.105
regulation of protein oligomerizationGO:0032459260.104
negative regulation of protein transportGO:0051224750.104
regulation of establishment of protein localization to plasma membraneGO:0090003300.102
regulation of endothelial cell migrationGO:0010594670.100
positive regulation of cell developmentGO:0010720920.100
cell morphogenesis involved in differentiationGO:00009041440.099
negative regulation of cell developmentGO:0010721480.099
cell projection organizationGO:00300302520.098
cell activationGO:00017752130.098
Mouse
regulation of neuron projection developmentGO:0010975570.097
divalent inorganic cation transportGO:00725111580.097
Human Mouse
protein processingGO:00164852260.097
cell cell signalingGO:00072671550.097
Mouse
organ formationGO:004864530.097
immune response regulating signaling pathwayGO:0002764970.097
Mouse
cell migration involved in sprouting angiogenesisGO:0002042190.097
carbohydrate metabolic processGO:00059752070.096
oxidation reduction processGO:00551143960.096
positive regulation of erk1 and erk2 cascadeGO:0070374750.095
positive regulation of calcium ion transportGO:0051928510.095
cellular response to oxygen containing compoundGO:19017012760.094
locomotory behaviorGO:000762610.092
positive regulation of cellular amine metabolic processGO:003324070.091
positive regulation of hydrolase activityGO:00513453310.091
positive regulation of apoptotic signaling pathwayGO:2001235700.090
Mouse
protein localization to organelleGO:00333652800.090
regulation of ion homeostasisGO:2000021730.090
regulation of angiogenesisGO:0045765920.088
regulation of cardiac muscle cell contractionGO:0086004230.088
blood circulationGO:00080151130.087
Mouse
regulation of receptor recyclingGO:0001919100.087
Mouse
cell cell signaling involved in cell fate commitmentGO:004516850.086
positive regulation of calcineurin nfat signaling cascadeGO:007088640.086
regulation of relaxation of muscleGO:190107730.086
regulation of protein import into nucleusGO:0042306780.086
cell adhesion mediated by integrinGO:0033627270.085
response to nerve growth factorGO:199008960.085
uterus morphogenesisGO:006103820.084
peptide transportGO:0015833740.084
regulation of substrate adhesion dependent cell spreadingGO:1900024190.084
regulation of cellular protein catabolic processGO:1903362960.083
Mouse
metal ion transportGO:00300012720.083
Human Mouse
negative regulation of ion transportGO:0043271390.083
regulation of transmembrane transporter activityGO:0022898740.083
organic hydroxy compound transportGO:0015850630.083
regulation of cellular amine metabolic processGO:0033238110.082
positive regulation of apoptotic processGO:00430652460.082
Mouse
generation of neuronsGO:00486991520.082
carboxylic acid transportGO:0046942630.081
negative regulation of transportGO:00510511760.081
macroautophagyGO:0016236390.081
negative regulation of protein complex disassemblyGO:0043242200.080
negative regulation of sequestering of calcium ionGO:0051283410.079
defense responseGO:00069523150.079
visual behaviorGO:000763220.079
regulation of collagen catabolic processGO:001071030.079
regulation of cell substrate adhesionGO:0010810680.078
regulation of striated muscle contractionGO:0006942370.077
behavioral response to ethanolGO:004814920.077
proteasomal protein catabolic processGO:00104981760.077
Mouse
immune response activating signal transductionGO:0002757900.077
Mouse
receptor metabolic processGO:0043112810.076
Mouse
regulation of protein depolymerizationGO:1901879220.076
purine ribonucleoside monophosphate metabolic processGO:00091671860.074
lymphangiogenesisGO:000194670.074
regulation of secretionGO:00510461940.073
cellular component assembly involved in morphogenesisGO:0010927730.073
neuron developmentGO:00486661130.073
glycoprotein metabolic processGO:00091001100.072
hair cycle phaseGO:004485130.072
Mouse
protein import into nucleusGO:00066061040.072
positive regulation of homeostatic processGO:0032846470.072
appendage morphogenesisGO:0035107160.072
Mouse
purine nucleoside triphosphate catabolic processGO:00091463920.071
cellular component disassemblyGO:0022411920.071
regulation of cysteine type endopeptidase activityGO:20001161270.071
multicellular organismal agingGO:001025930.071
cytosolic calcium ion transportGO:0060401480.070
response to light stimulusGO:0009416870.070
regulation of muscle contractionGO:0006937450.070
single organism reproductive processGO:0044702980.070
dopamine receptor signaling pathwayGO:0007212100.069
regulation of ion transportGO:00432691890.069
female gamete generationGO:000729220.069
cellular cation homeostasisGO:00300031630.069
Human Mouse
regulation of nervous system developmentGO:0051960880.068
purine ribonucleoside triphosphate metabolic processGO:00092054110.068
negative regulation of catabolic processGO:00098951040.068
Mouse
negative regulation of cell proliferationGO:00082852280.067
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.067
atp catabolic processGO:00062001570.067
protein stabilizationGO:0050821640.067
regulation of calcium ion transmembrane transporter activityGO:1901019280.066
ectoderm developmentGO:000739830.066
regulation of cell motilityGO:20001452990.066
response to radiationGO:00093141510.066
regulation of cell cycle processGO:00105642660.065
glucose homeostasisGO:0042593310.065
dephosphorylationGO:00163112090.065
response to oxidative stressGO:00069791210.065
regulation of microtubule depolymerizationGO:0031114120.064
positive regulation of cellular component movementGO:00512721810.064
regulation of release of sequestered calcium ion into cytosolGO:0051279270.063
cellular ketone metabolic processGO:0042180800.063
neurogenesisGO:00220081690.062
Zebrafish
single organism nuclear importGO:19025931040.062
negative regulation of protein kinase b signalingGO:0051898170.062
macromolecule glycosylationGO:0043413630.062
positive regulation of developmental processGO:00510943140.062
negative regulation of peptidyl tyrosine phosphorylationGO:0050732200.062
Mouse
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.061
Mouse
calcium ion transportGO:00068161470.061
Human Mouse
negative regulation of hydrolase activityGO:00513461820.061
amino acid transportGO:0006865280.061
regulation of peptide transportGO:0090087620.061
cilium morphogenesisGO:0060271750.060
maintenance of protein location in cellGO:0032507560.060
reproductive processGO:00224141060.060
cytoplasmic transportGO:00164823790.060
cellular extravasationGO:0045123210.059
regulation of ligase activityGO:0051340290.059
Mouse
neuron differentiationGO:00301821380.059
negative regulation of protein bindingGO:0032091350.058
Mouse
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.058
regulation of release of cytochrome c from mitochondriaGO:0090199290.058
epidermis developmentGO:0008544590.058
Mouse
endosomal transportGO:00161971290.057
regulation of protein localization to nucleusGO:1900180850.057
positive regulation of cellular component biogenesisGO:00440891580.057
nuclear importGO:00511701060.057
hormone transportGO:0009914680.056
macromolecular complex disassemblyGO:0032984600.055
regulation of secretion by cellGO:19035301770.055
ribonucleotide catabolic processGO:00092614050.055
negative regulation of ion transmembrane transportGO:0034766260.055
insulin secretionGO:0030073390.055
negative regulation of transferase activityGO:00513481240.055
Mouse
carbohydrate homeostasisGO:0033500310.055
regulation of neuron differentiationGO:0045664700.055
regulation of endopeptidase activityGO:00525481700.054
cilium assemblyGO:0042384630.054
cellular ion homeostasisGO:00068731680.054
Human Mouse
pattern specification processGO:0007389430.054
Mouse
response to hypoxiaGO:0001666960.054
cellular protein complex disassemblyGO:0043624360.053
protein targeting to nucleusGO:00447441040.052
maintenance of locationGO:00512351120.052
negative regulation of protein depolymerizationGO:1901880170.052
regulation of ubiquitin protein transferase activityGO:0051438280.052
Mouse
response to cytokineGO:00340972320.051
regulation of erk1 and erk2 cascadeGO:0070372990.051
transition metal ion transportGO:0000041230.051
segmentationGO:003528240.051
Mouse
ribonucleoside catabolic processGO:00424544060.051
regulation of calcium ion transmembrane transportGO:1903169280.050
calcium ion transport into cytosolGO:0060402480.050
regulation of kinase activityGO:00435493140.050
Mouse
positive regulation of cell matrix adhesionGO:0001954230.050
acidic amino acid transportGO:001580060.049
adenylate cyclase inhibiting g protein coupled receptor signaling pathwayGO:0007193220.049
negative regulation of immune system processGO:00026831360.049

PSEN2 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:172230.899
myopathyDOID:4231040.830
muscular diseaseDOID:00800001140.830
heart diseaseDOID:114680.830
cardiomyopathyDOID:0050700500.830
dilated cardiomyopathyDOID:12930320.830
intrinsic cardiomyopathyDOID:0060036500.830
cardiovascular system diseaseDOID:12871060.830
muscle tissue diseaseDOID:661130.830
disease of mental healthDOID:150700.751
cognitive disorderDOID:1561290.751
central nervous system diseaseDOID:3311860.750
tauopathyDOID:680160.750
neurodegenerative diseaseDOID:12891020.750
nervous system diseaseDOID:8634310.750
dementiaDOID:1307190.548
skin diseaseDOID:37330.278
Human
integumentary system diseaseDOID:16430.278
Human
bone development diseaseDOID:0080006550.260
bone diseaseDOID:0080001880.260
connective tissue diseaseDOID:651090.260
brain diseaseDOID:936730.133
Human
alzheimer s diseaseDOID:10652160.054