Homo sapiens

192 known processes

TNNI3

troponin I type 3 (cardiac)

(Aliases: RCM1,cTnI,MGC116817,TNNC1,CMD1FF,CMD2A,CMH7)

TNNI3 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
system processGO:00030083490.502
blood circulationGO:00080151130.322
inorganic ion transmembrane transportGO:00986602310.249
cation transportGO:00068123310.246
muscle contractionGO:0006936730.244
muscle system processGO:0003012810.224
actin mediated cell contractionGO:0070252120.218
metal ion transportGO:00300012720.195
purine ribonucleotide catabolic processGO:00091544040.188
nucleotide catabolic processGO:00091664080.183
purine nucleoside catabolic processGO:00061523980.175
skeletal muscle contractionGO:0003009160.169
Human
ion transmembrane transportGO:00342203380.169
transmembrane transportGO:00550853990.168
actin filament based movementGO:0030048170.161
striated muscle contractionGO:0006941520.153
cardiovascular system developmentGO:00723582620.149
purine nucleoside triphosphate catabolic processGO:00091463920.144
organophosphate catabolic processGO:00464344300.143
purine containing compound catabolic processGO:00725234110.143
cellular potassium ion transportGO:0071804600.139
nucleoside phosphate catabolic processGO:19012924120.130
purine nucleoside triphosphate metabolic processGO:00091444120.130
cardiac muscle contractionGO:0060048340.126
ribonucleoside triphosphate catabolic processGO:00092033910.123
potassium ion transmembrane transportGO:0071805600.122
circulatory system developmentGO:00723592620.120
ribonucleoside triphosphate metabolic processGO:00091994120.118
monovalent inorganic cation transportGO:00156721280.110
nucleoside triphosphate metabolic processGO:00091414220.109
ribonucleoside catabolic processGO:00424544060.106
sodium ion transmembrane transportGO:0035725590.103
purine nucleotide catabolic processGO:00061954050.101
regulation of cellular component movementGO:00512703340.098
inorganic cation transmembrane transportGO:00986621940.097
cellular amine metabolic processGO:0044106410.096
regulation of system processGO:00440571010.095
nucleoside catabolic processGO:00091644080.095
ribonucleoside monophosphate catabolic processGO:00091581580.095
cation transmembrane transportGO:00986552380.094
amine metabolic processGO:0009308440.093
cellular amino acid metabolic processGO:00065201160.091
cellular ketone metabolic processGO:0042180800.090
ion homeostasisGO:00508012300.089
ribonucleotide catabolic processGO:00092614050.089
actin filament based processGO:00300292240.085
purine ribonucleoside triphosphate metabolic processGO:00092054110.082
circulatory system processGO:00030131130.080
heart contractionGO:0060047620.080
regulation of muscle system processGO:0090257530.078
purine ribonucleoside metabolic processGO:00461284370.078
purine ribonucleoside monophosphate metabolic processGO:00091671860.076
regulation of cellular amino acid metabolic processGO:000652160.075
nucleoside monophosphate catabolic processGO:00091251590.075
multicellular organismal movementGO:0050879170.075
Human
regulation of nucleoside metabolic processGO:00091182090.075
sodium ion transportGO:0006814610.073
potassium ion transportGO:0006813620.073
ribonucleoside monophosphate metabolic processGO:00091611870.072
regulation of nucleotide catabolic processGO:00308112050.071
nucleoside triphosphate catabolic processGO:00091433940.070
negative regulation of phosphate metabolic processGO:00459362670.070
purine ribonucleoside catabolic processGO:00461303980.069
purine ribonucleoside triphosphate catabolic processGO:00092073910.069
purine nucleoside monophosphate catabolic processGO:00091281580.069
regulation of cellular ketone metabolic processGO:0010565500.067
anatomical structure formation involved in morphogenesisGO:00486462840.066
cardiac muscle tissue developmentGO:0048738390.066
negative regulation of catalytic activityGO:00430863350.065
skeletal muscle thin filament assemblyGO:003024030.065
glycosyl compound catabolic processGO:19016584130.065
striated muscle adaptationGO:001488840.064
g protein coupled receptor signaling pathwayGO:00071862070.064
regulation of nucleotide metabolic processGO:00061402690.064
sensory perception of sour tasteGO:005091550.063
regulation of atpase activityGO:0043462250.062
regulation of atp metabolic processGO:1903578290.061
post embryonic developmentGO:000979120.060
striated muscle tissue developmentGO:0014706590.059
regulation of cellular amine metabolic processGO:0033238110.058
nucleoside monophosphate metabolic processGO:00091231910.058
voluntary skeletal muscle contractionGO:000301010.058
regulation of purine nucleotide metabolic processGO:19005422640.058
positive regulation of cellular amine metabolic processGO:003324070.057
negative regulation of cell deathGO:00605483450.056
positive regulation of cellular catabolic processGO:00313312840.056
cellular component morphogenesisGO:00329893140.056
muscle structure developmentGO:0061061980.056
muscle organ morphogenesisGO:0048644190.054
purine nucleoside monophosphate metabolic processGO:00091261860.054
positive regulation of cellular amino acid metabolic processGO:004576430.053
response to abiotic stimulusGO:00096283360.053
positive regulation of catabolic processGO:00098963100.052
tissue morphogenesisGO:0048729960.052
organ morphogenesisGO:00098871470.052
purine ribonucleoside monophosphate catabolic processGO:00091691580.052
regulation of ion transmembrane transportGO:00347651320.052
atp catabolic processGO:00062001570.050
locomotory behaviorGO:000762610.049
regulation of purine nucleotide catabolic processGO:00331212050.049
cellular component assembly involved in morphogenesisGO:0010927730.049
atp metabolic processGO:00460341760.048
cardiac muscle tissue morphogenesisGO:0055008180.048
musculoskeletal movementGO:0050881170.047
Human
regulation of atp catabolic processGO:1903289250.047
cell cell signalingGO:00072671550.046
cellular macromolecule catabolic processGO:00442653800.046
negative regulation of multicellular organismal processGO:00512413170.046
cell developmentGO:00484683280.046
positive regulation of nucleotide catabolic processGO:00308131850.046
response to oxygen containing compoundGO:19017003690.046
positive regulation of transportGO:00510503360.045
small gtpase mediated signal transductionGO:0007264780.045
cardiac muscle cell contractionGO:008600340.044
regulation of blood circulationGO:1903522590.044
negative regulation of protein metabolic processGO:00512483910.044
negative regulation of hydrolase activityGO:00513461820.043
regulation of ion transportGO:00432691890.042
regulation of muscle contractionGO:0006937450.042
neurological system processGO:00508771630.041
positive regulation of nucleotide metabolic processGO:00459812300.041
secretionGO:00469032540.041
nervous system developmentGO:00073992930.040
response to metal ionGO:0010038840.040
muscle tissue developmentGO:0060537620.040
positive regulation of phosphorylationGO:00423273940.040
regulation of kinase activityGO:00435493140.038
protein ubiquitinationGO:00165673140.038
regulation of protein kinase activityGO:00458592890.038
actin myosin filament slidingGO:003327560.038
muscle organ developmentGO:0007517560.037
heart morphogenesisGO:0003007480.037
regulation of transferase activityGO:00513383550.037
heart processGO:0003015620.037
protein modification by small protein conjugationGO:00324463420.037
angiogenesisGO:00015251470.037
protein homooligomerizationGO:00512601000.036
lipid metabolic processGO:00066293810.036
negative regulation of cellular protein metabolic processGO:00322693530.036
ras protein signal transductionGO:0007265730.035
positive regulation of ion transportGO:0043270870.034
sensory perceptionGO:00076001030.034
cellular homeostasisGO:00197251960.034
metal ion homeostasisGO:00550651690.034
cellular response to endogenous stimulusGO:00714953360.034
protein catabolic processGO:00301633250.033
cation homeostasisGO:00550801890.033
multicellular organismal agingGO:001025930.033
negative regulation of programmed cell deathGO:00430693210.033
female gamete generationGO:000729220.033
oogenesisGO:004847720.033
negative regulation of phosphorus metabolic processGO:00105632670.033
negative regulation of apoptotic processGO:00430663160.033
response to inorganic substanceGO:00100351270.032
neuromuscular junction developmentGO:000752830.032
positive regulation of purine nucleotide metabolic processGO:19005442270.032
cell adhesionGO:00071553250.032
regulation of cellular response to stressGO:00801352440.031
divalent inorganic cation homeostasisGO:00725071360.031
organelle assemblyGO:00709251760.031
small molecule biosynthetic processGO:00442831570.031
regulation of transmembrane transportGO:00347621390.031
positive regulation of hydrolase activityGO:00513453310.030
micturitionGO:006007330.030
blood vessel developmentGO:00015681720.030
positive regulation of nucleoside metabolic processGO:00459791860.030
regulation of striated muscle contractionGO:0006942370.030
response to organic cyclic compoundGO:00140702040.030
cellular chemical homeostasisGO:00550821800.029
regulation of cell differentiationGO:00455953930.029
regulation of heart contractionGO:0008016500.029
segmentationGO:003528240.029
regulation of actin filament based processGO:00329701410.029
mapk cascadeGO:00001652880.029
cytoplasmic transportGO:00164823790.029
mitotic cell cycleGO:00002783260.029
regulation of acetylcholine gated cation channel activityGO:190304810.028
lipid biosynthetic processGO:00086101770.028
organonitrogen compound biosynthetic processGO:19015662000.028
heart developmentGO:0007507950.028
negative regulation of intracellular signal transductionGO:19025321830.028
cellular cation homeostasisGO:00300031630.028
determination of adult lifespanGO:000834020.028
vasculature developmentGO:00019441810.028
regulation of locomotionGO:00400123290.027
regulation of intracellular transportGO:00323861950.027
muscle filament slidingGO:003004950.027
sensory perception of tasteGO:0050909360.027
epithelial tube branching involved in lung morphogenesisGO:006044140.027
negative regulation of muscle contractionGO:004593230.027
rho protein signal transductionGO:0007266260.027
chemical homeostasisGO:00488783060.027
positive regulation of cell proliferationGO:00082843010.027
cellular response to dna damage stimulusGO:00069743790.027
positive regulation of cell deathGO:00109422630.027
positive regulation of transferase activityGO:00513472270.026
cellular protein catabolic processGO:00442572610.026
ventricular cardiac muscle tissue developmentGO:0003229140.026
regulation of proteolysisGO:00301622930.026
response to radiationGO:00093141510.026
cellular ion homeostasisGO:00068731680.026
defense responseGO:00069523150.026
muscle adaptationGO:0043500120.025
positive regulation of protein phosphorylationGO:00019343130.025
regulation of protein serine threonine kinase activityGO:00719001790.024
regulation of transmembrane transporter activityGO:0022898740.024
positive regulation of purine nucleotide catabolic processGO:00331231850.024
regulation of transporter activityGO:0032409820.024
secretion by cellGO:00329402260.024
twitch skeletal muscle contractionGO:001472110.024
regulation of ion transmembrane transporter activityGO:0032412720.024
signal transduction by phosphorylationGO:00230142970.024
vesicle mediated transportGO:00161923710.023
synaptic transmission cholinergicGO:000727120.023
positive regulation of cellular component organizationGO:00511303760.023
enzyme linked receptor protein signaling pathwayGO:00071673030.023
immune responseGO:00069553070.023
reactive oxygen species metabolic processGO:0072593750.023
cardiac chamber morphogenesisGO:0003206260.023
memoryGO:000761330.023
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.023
negative regulation of cellular catabolic processGO:0031330830.023
cellular response to oxygen containing compoundGO:19017012760.023
apoptotic signaling pathwayGO:00971902680.023
biological adhesionGO:00226103310.023
chromatin organizationGO:00063253510.022
maintenance of locationGO:00512351120.022
regulation of metal ion transportGO:00109591200.022
neurogenesisGO:00220081690.022
cellular protein complex assemblyGO:00436231880.022
gtp catabolic processGO:00061842370.022
neuron fate commitmentGO:004866320.022
regulation of endopeptidase activityGO:00525481700.022
protein processingGO:00164852260.022
actin cytoskeleton organizationGO:00300362070.022
generation of neuronsGO:00486991520.022
synaptic transmission involved in micturitionGO:006008420.022
adult locomotory behaviorGO:000834410.022
negative regulation of transportGO:00510511760.022
regulation of homeostatic processGO:00328441210.022
action potentialGO:0001508340.022
blood vessel morphogenesisGO:00485141620.021
calcium ion homeostasisGO:00550741220.021
regulation of protein localizationGO:00328802960.021
guanosine containing compound metabolic processGO:19010682440.021
regulation of cell cycleGO:00517263930.021
mitotic cell cycle processGO:19030472860.021
epithelium developmentGO:00604292270.021
regulation of cell migrationGO:00303342890.021
protein oligomerizationGO:00512591730.021
cellular macromolecular complex assemblyGO:00346223240.021
morphogenesis of embryonic epitheliumGO:001633140.021
negative regulation of cellular amine metabolic processGO:003323930.021
postsynaptic membrane organizationGO:000194120.021
negative regulation of catabolic processGO:00098951040.021
cardiac ventricle morphogenesisGO:0003208200.021
cell projection organizationGO:00300302520.021
regulation of actin filament based movementGO:1903115240.021
cell morphogenesisGO:00009022960.021
dephosphorylationGO:00163112090.021
microtubule based processGO:00070172100.021
negative regulation of acetylcholine gated cation channel activityGO:190304910.020
membrane organizationGO:00610242920.020
response to external biotic stimulusGO:00432072610.020
carboxylic acid biosynthetic processGO:0046394970.020
regulation of body fluid levelsGO:0050878990.020
negative regulation of cellular component organizationGO:00511292350.020
protein localization to organelleGO:00333652800.020
regulation of peptidase activityGO:00525471800.020
translationGO:00064121320.020
regulation of anatomical structure morphogenesisGO:00226032860.020
negative regulation of cellular amino acid metabolic processGO:004576320.020
cardiac chamber developmentGO:0003205300.020
carbohydrate derivative biosynthetic processGO:19011372070.020
sensory perception of chemical stimulusGO:0007606380.020
cellular metal ion homeostasisGO:00068751460.020
divalent metal ion transportGO:00708381520.019
head developmentGO:00603221080.019
regulation of mapk cascadeGO:00434082620.019
peripheral nervous system developmentGO:000742220.019
lung alveolus developmentGO:004828640.019
hemostasisGO:0007599760.019
single organism cell adhesionGO:00986021790.019
organic acid biosynthetic processGO:0016053970.019
single organism membrane organizationGO:00448022680.019
regulation of vasculature developmentGO:1901342970.019
regulation of hormone levelsGO:00108171250.019
cellular calcium ion homeostasisGO:00068741170.019
regulation of membrane potentialGO:0042391950.019
response to activityGO:001482300.019
positive regulation of programmed cell deathGO:00430682490.019
response to growth factorGO:00708482050.019
negative regulation of protein modification processGO:00314002000.018
epithelium migrationGO:00901321190.018
startle responseGO:000196430.018
modification dependent macromolecule catabolic processGO:00436322120.018
central nervous system developmentGO:00074171230.018
blastoderm segmentationGO:000735020.018
response to organonitrogen compoundGO:00102431560.018
hindbrain developmentGO:003090230.018
gtp metabolic processGO:00460392390.018
cellular divalent inorganic cation homeostasisGO:00725031280.018
blood coagulationGO:0007596760.018
single organism carbohydrate metabolic processGO:00447231930.018
small molecule catabolic processGO:0044282920.018
proteolysis involved in cellular protein catabolic processGO:00516032440.018
response to cytokineGO:00340972320.018
response to woundingGO:00096111680.018
guanosine containing compound catabolic processGO:19010692390.018
spinal cord developmentGO:002151040.018
oocyte developmentGO:004859910.018
single organism cellular localizationGO:19025803320.018
regulation of multi organism processGO:00439001570.018
organ formationGO:004864530.018
regulation of cell growthGO:00015581350.018
motor neuron axon guidanceGO:000804520.017
innate immune responseGO:00450871780.017
reactive oxygen species biosynthetic processGO:190340940.017
embryonic epithelial tube formationGO:000183840.017
reactive nitrogen species metabolic processGO:200105730.017
protein maturationGO:00516042330.017
wound healingGO:00420601150.017
regulation of cellular component biogenesisGO:00440872810.017
positive regulation of cytosolic calcium ion concentrationGO:0007204820.017
regulation of secretionGO:00510461940.017
modification dependent protein catabolic processGO:00199412090.017
coagulationGO:0050817780.017
nitrogen compound transportGO:00717051910.017
posttranscriptional regulation of gene expressionGO:00106082130.017
cell cycle phase transitionGO:00447701730.017
cell fate determinationGO:000170930.017
dna repairGO:00062811980.017
neuron differentiationGO:00301821380.017
oxidation reduction processGO:00551143960.017
cardiac ventricle developmentGO:0003231230.017
negative regulation of cell cycleGO:00457861930.017
oocyte differentiationGO:000999420.017
regulation of cytokine productionGO:00018172320.017
divalent inorganic cation transportGO:00725111580.017
growthGO:00400072020.016
actin filament organizationGO:00070151280.016
positive regulation of protein kinase activityGO:00458601900.016
mitotic cell cycle phase transitionGO:00447721620.016
visual behaviorGO:000763220.016
response to decreased oxygen levelsGO:0036293960.016
ventricular cardiac muscle tissue morphogenesisGO:0055010140.016
negative regulation of protein processingGO:00109551420.016
ubiquitin dependent protein catabolic processGO:00065112060.016
matingGO:000761810.016
monocarboxylic acid metabolic processGO:00327871850.016
negative regulation of phosphorylationGO:00423261740.016
regulation of response to external stimulusGO:00321012220.016
proteasomal protein catabolic processGO:00104981760.016
neuroblast proliferationGO:000740540.016
negative regulation of cell proliferationGO:00082852280.016
cellular response to glucocorticoid stimulusGO:007138540.016
response to extracellular stimulusGO:0009991850.016
cell growthGO:00160491600.016
respiratory gaseous exchangeGO:000758530.016
carbohydrate metabolic processGO:00059752070.016
visual learningGO:000854210.016
regulation of synaptic plasticityGO:004816730.016
associative learningGO:000830610.015
regulation of angiogenesisGO:0045765920.015
cytokine productionGO:00018162470.015
spermatid differentiationGO:004851540.015
positive regulation of hormone biosynthetic processGO:004688640.015
fatty acid metabolic processGO:00066311150.015
anatomical structure homeostasisGO:00602491000.015
response to biotic stimulusGO:00096072760.015
regulation of cell motilityGO:20001452990.015
renal system developmentGO:0072001630.015
response to hypoxiaGO:0001666960.015
organic hydroxy compound metabolic processGO:19016151470.015
positive regulation of locomotionGO:00400171860.015
regenerationGO:003109940.015
specification of organ identityGO:001009230.015
cell differentiation in spinal cordGO:002151510.015
regulation of secretion by cellGO:19035301770.015
response to other organismGO:00517072610.015
cellular response to nitrogen compoundGO:19016991440.015
peptidyl tyrosine modificationGO:00182121700.015
anterior posterior axis specificationGO:000994820.015
negative regulation of locomotionGO:00400131180.015
activation of mapk activity by adrenergic receptor signaling pathwayGO:007188330.015
negative regulation of developmental processGO:00510932470.015
organophosphate biosynthetic processGO:00904071630.015
inner ear morphogenesisGO:004247240.015
intrinsic apoptotic signaling pathwayGO:00971931270.015
response to hormoneGO:00097251750.015
cellular response to cytokine stimulusGO:00713451810.015
regulation of small gtpase mediated signal transductionGO:00510561560.015
response to oxygen levelsGO:00704821000.015
negative regulation of cell growthGO:0030308830.015
cellular lipid metabolic processGO:00442553030.015
compound eye developmentGO:004874910.015
cellular response to growth factor stimulusGO:00713631970.014
regulation of cell cycle processGO:00105642660.014
negative regulation of protein maturationGO:19033181420.014
anion transportGO:00068201610.014
regulation of cell developmentGO:00602841610.014
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.014
regulation of apoptotic signaling pathwayGO:20012331750.014
cellular response to hormone stimulusGO:00328701250.014
cellular response to external stimulusGO:00714961110.014
spermatid developmentGO:000728640.014
regulation of establishment of protein localizationGO:00702012420.014
histone modificationGO:00165702510.014
nucleotide biosynthetic processGO:00091651090.014
regulation of cysteine type endopeptidase activityGO:20001161270.014
regulation of sequence specific dna binding transcription factor activityGO:00510902110.014
metencephalon developmentGO:002203720.014
cytosolic calcium ion homeostasisGO:0051480890.014
response to nitrogen compoundGO:19016981840.014
positive regulation of synaptic transmissionGO:005080640.014
intracellular protein transportGO:00068862700.014
positive regulation of secretionGO:00510471160.014
lipid localizationGO:00108761060.014
regulation of growthGO:00400081650.014
chromatin modificationGO:00165682980.014
negative regulation of proteolysisGO:00458611320.014
response to lipidGO:00339932060.014
activation of protein kinase activityGO:0032147900.014
epidermal growth factor activated receptor transactivation by g protein coupled receptor signaling pathwayGO:003562540.014
multicellular organismal response to stressGO:003355510.014
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.013
regulation of i kappab kinase nf kappab signalingGO:00431221620.013
sensory perception of painGO:001923340.013
positive regulation of apoptotic processGO:00430652460.013
autophagyGO:0006914880.013
response to light stimulusGO:0009416870.013
calcium ion transportGO:00068161470.013
positive regulation of mapk cascadeGO:00434101900.013
regulation of protein complex assemblyGO:00432541470.013
endothelial cell migrationGO:0043542860.013
regulation of protein processingGO:00706131500.013
positive regulation of organelle organizationGO:00106381950.013
cell projection morphogenesisGO:00488581290.013
regulation of protein catabolic processGO:00421761550.013
regulation of protein maturationGO:19033171500.013
tissue migrationGO:00901301190.013
regulation of gtpase activityGO:00430871800.013
muscle cell differentiationGO:0042692630.013
nerve developmentGO:002167540.013
positive regulation of cellular component movementGO:00512721810.013
negative regulation of cell motilityGO:20001461040.013
photoreceptor cell differentiationGO:004653020.013
cell fate commitment involved in pattern specificationGO:006058110.013
positive regulation of kinase activityGO:00336742040.013
t cell differentiation in thymusGO:003307740.013
cell projection assemblyGO:00300311260.013
peptidyl tyrosine phosphorylationGO:00181081700.013
regulation of dna metabolic processGO:00510521530.013
negative regulation of blood pressureGO:004577630.013
mitochondrion organizationGO:00070051560.013
organic hydroxy compound transportGO:0015850630.013
negative regulation of protein phosphorylationGO:00019331400.013
regulation of protein ubiquitinationGO:0031396950.013
regulation of ras gtpase activityGO:00323181280.013
regulation of ras protein signal transductionGO:00465781550.013
limbic system developmentGO:002176130.013
positive regulation of proteolysisGO:00458621420.013
cilium organizationGO:0044782680.013
cellular response to organic cyclic compoundGO:00714071270.013
positive regulation of cell migrationGO:00303351720.013
negative regulation of endopeptidase activityGO:0010951840.012
endomembrane system organizationGO:00102561960.012
single organismal cell cell adhesionGO:00163371480.012
positive regulation of secretion by cellGO:19035321080.012
response to virusGO:00096151260.012
axis elongationGO:000340140.012
positive regulation of reactive oxygen species metabolic processGO:2000379240.012

TNNI3 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
heart diseaseDOID:114680.348
cardiovascular system diseaseDOID:12871060.348
intrinsic cardiomyopathyDOID:0060036500.324
musculoskeletal system diseaseDOID:172230.324
cardiomyopathyDOID:0050700500.324
muscle tissue diseaseDOID:661130.324
hypertrophic cardiomyopathyDOID:11984210.324
myopathyDOID:4231040.324
muscular diseaseDOID:00800001140.324
dilated cardiomyopathyDOID:12930320.047
disease of metabolismDOID:00146672950.030
primary ciliary dyskinesiaDOID:9562270.022
nervous system diseaseDOID:8634310.021
central nervous system diseaseDOID:3311860.021
disease of cellular proliferationDOID:145661740.018
inherited metabolic disorderDOID:6552420.018
cancerDOID:1621670.018
bone diseaseDOID:0080001880.017
connective tissue diseaseDOID:651090.017
organ system cancerDOID:00506861640.017
neurodegenerative diseaseDOID:12891020.013