Homo sapiens

64 known processes

PLK4

polo-like kinase 4

(Aliases: SAK,STK18)

PLK4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
nucleoside monophosphate metabolic processGO:00091231910.527
chromosome segregationGO:00070591140.498
cell divisionGO:00513011680.427
mitotic cell cycleGO:00002783260.415
Fly
regulation of cytoskeleton organizationGO:00514931770.392
nuclear divisionGO:00002801280.353
Fly
microtubule cytoskeleton organizationGO:00002261760.316
regulation of cell cycleGO:00517263930.308
meiotic chromosome segregationGO:004513240.293
somatic stem cell divisionGO:004810310.278
microtubule based processGO:00070172100.277
centrosome organizationGO:0051297580.262
purine nucleotide catabolic processGO:00061954050.245
nucleoside triphosphate metabolic processGO:00091414220.241
mitotic nuclear divisionGO:00070671190.224
organelle fissionGO:00482851490.221
Fly
nucleoside phosphate catabolic processGO:19012924120.220
ribonucleotide catabolic processGO:00092614050.215
microtubule polymerization or depolymerizationGO:0031109370.202
mitotic cell cycle processGO:19030472860.176
Fly
microtubule organizing center organizationGO:0031023620.169
regulation of cell cycle processGO:00105642660.165
purine nucleoside catabolic processGO:00061523980.149
nucleoside triphosphate catabolic processGO:00091433940.145
dna repairGO:00062811980.138
organophosphate catabolic processGO:00464344300.126
purine nucleoside triphosphate metabolic processGO:00091444120.120
negative regulation of cell cycle processGO:00109481210.120
cellular macromolecular complex assemblyGO:00346223240.120
purine nucleoside triphosphate catabolic processGO:00091463920.119
ribonucleoside monophosphate catabolic processGO:00091581580.113
nucleoside monophosphate catabolic processGO:00091251590.111
ribonucleoside triphosphate catabolic processGO:00092033910.110
purine ribonucleotide catabolic processGO:00091544040.106
positive regulation of cell cycleGO:00457871400.101
double strand break repairGO:00063021010.101
regulation of microtubule cytoskeleton organizationGO:0070507610.096
regulation of mitotic cell cycleGO:00073461890.095
purine ribonucleoside monophosphate catabolic processGO:00091691580.095
ribonucleoside catabolic processGO:00424544060.095
purine ribonucleoside triphosphate catabolic processGO:00092073910.091
purine ribonucleoside metabolic processGO:00461284370.089
mitotic cell cycle checkpointGO:0007093680.089
post embryonic developmentGO:000979120.086
nervous system developmentGO:00073992930.086
cell cycle phase transitionGO:00447701730.084
organelle assemblyGO:00709251760.083
regenerationGO:003109940.081
regulation of protein localizationGO:00328802960.079
purine containing compound catabolic processGO:00725234110.075
ribonucleoside monophosphate metabolic processGO:00091611870.073
mitotic cell cycle phase transitionGO:00447721620.073
cellular macromolecule catabolic processGO:00442653800.073
ribonucleoside triphosphate metabolic processGO:00091994120.071
sister chromatid segregationGO:0000819540.071
neuroblast divisionGO:005505710.070
purine ribonucleoside catabolic processGO:00461303980.070
negative regulation of mitotic cell cycle phase transitionGO:1901991850.069
centrosome cycleGO:0007098320.069
microtubule polymerizationGO:0046785180.066
mitotic sister chromatid segregationGO:0000070530.064
nucleoside catabolic processGO:00091644080.062
positive regulation of transferase activityGO:00513472270.060
embryo developmentGO:00097901230.058
Mouse Fly
positive regulation of protein phosphorylationGO:00019343130.055
glycosyl compound catabolic processGO:19016584130.055
atp catabolic processGO:00062001570.055
protein catabolic processGO:00301633250.053
Fly
dna conformation changeGO:00711031130.051
cell cycle checkpointGO:00000751170.050
negative regulation of cell cycleGO:00457861930.050
stem cell divisionGO:001714520.049
dna recombinationGO:0006310770.049
double strand break repair via homologous recombinationGO:0000724500.049
regulation of protein kinase activityGO:00458592890.048
negative regulation of protein metabolic processGO:00512483910.047
regulation of transferase activityGO:00513383550.047
regulation of cell divisionGO:00513021160.046
regulation of kinase activityGO:00435493140.046
regulation of protein catabolic processGO:00421761550.045
Fly
regulation of mitotic sister chromatid segregationGO:0033047270.045
regulation of proteasomal protein catabolic processGO:0061136870.044
atp metabolic processGO:00460341760.044
negative regulation of mitotic metaphase anaphase transitionGO:0045841170.043
cytokinesisGO:0000910960.042
regulation of cellular response to stressGO:00801352440.042
neurogenesisGO:00220081690.041
spindle assemblyGO:0051225290.040
neuronal stem cell divisionGO:003644510.039
mitotic spindle checkpointGO:0071174180.039
regulation of cell cycle phase transitionGO:19019871260.039
purine nucleoside monophosphate metabolic processGO:00091261860.039
positive regulation of protein serine threonine kinase activityGO:00719021190.038
meiosis iGO:000712740.038
protein modification by small protein conjugationGO:00324463420.037
purine ribonucleoside triphosphate metabolic processGO:00092054110.036
microtubule anchoringGO:0034453240.035
dna replicationGO:00062601160.035
proteolysis involved in cellular protein catabolic processGO:00516032440.035
spindle organizationGO:0007051530.035
Fly
meiotic cell cycleGO:0051321130.034
Fly
modification dependent macromolecule catabolic processGO:00436322120.034
cellular protein complex disassemblyGO:0043624360.034
maintenance of locationGO:00512351120.034
positive regulation of cell cycle processGO:00900681060.034
establishment of organelle localizationGO:0051656590.034
regulation of purine nucleotide metabolic processGO:19005422640.034
positive regulation of purine nucleotide catabolic processGO:00331231850.033
modification dependent protein catabolic processGO:00199412090.033
regulation of cellular protein catabolic processGO:1903362960.033
proteasomal protein catabolic processGO:00104981760.032
nucleotide catabolic processGO:00091664080.032
regulation of sister chromatid segregationGO:0033045270.032
anatomical structure homeostasisGO:00602491000.031
protein localization to organelleGO:00333652800.031
regulation of dna metabolic processGO:00510521530.031
positive regulation of kinase activityGO:00336742040.030
asymmetric neuroblast divisionGO:005505910.030
chromatin organizationGO:00063253510.030
ubiquitin dependent protein catabolic processGO:00065112060.029
purine ribonucleoside monophosphate metabolic processGO:00091671860.029
cell developmentGO:00484683280.029
Fly
protein polymerizationGO:0051258710.029
neuroblast proliferationGO:000740540.029
small gtpase mediated signal transductionGO:0007264780.028
regulation of protein serine threonine kinase activityGO:00719001790.028
cellular component disassemblyGO:0022411920.028
neural tube formationGO:000184130.028
regulation of chromosome segregationGO:0051983440.028
cell fate determinationGO:000170930.028
regulation of mitosisGO:0007088630.028
mitotic spindle organizationGO:0007052270.027
Fly
purine nucleoside monophosphate catabolic processGO:00091281580.027
cellular component morphogenesisGO:00329893140.027
Fly
negative regulation of mitotic cell cycleGO:00459301020.027
embryonic epithelial tube formationGO:000183840.027
cellular response to dna damage stimulusGO:00069743790.027
spindle checkpointGO:0031577260.027
chromatin modificationGO:00165682980.026
dna dependent dna replicationGO:0006261440.026
endomembrane system organizationGO:00102561960.026
reproductionGO:0000003630.026
Fly
blastocyst developmentGO:000182430.026
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434710.026
regulation of protein processingGO:00706131500.026
growthGO:00400072020.026
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.025
chromosome separationGO:0051304230.025
ras protein signal transductionGO:0007265730.025
protein processingGO:00164852260.025
maintenance of location in cellGO:0051651620.024
negative regulation of apoptotic processGO:00430663160.024
negative regulation of organelle organizationGO:00106391260.024
regulation of mitotic metaphase anaphase transitionGO:0030071260.024
cellular protein catabolic processGO:00442572610.023
positive regulation of purine nucleotide metabolic processGO:19005442270.023
regulation of response to dna damage stimulusGO:2001020940.023
regulation of establishment of protein localizationGO:00702012420.023
regulation of cell differentiationGO:00455953930.023
negative regulation of cellular component organizationGO:00511292350.023
negative regulation of sister chromatid segregationGO:0033046170.023
single organism reproductive processGO:0044702980.023
Mouse Fly
protein ubiquitinationGO:00165673140.022
single organism cellular localizationGO:19025803320.022
cell projection morphogenesisGO:00488581290.022
Fly
negative regulation of programmed cell deathGO:00430693210.022
positive regulation of mitotic cell cycleGO:0045931600.022
negative regulation of cellular catabolic processGO:0031330830.022
positive regulation of phosphorylationGO:00423273940.022
regulation of cellular component biogenesisGO:00440872810.022
mitotic sister chromatid separationGO:0051306180.022
regulation of cytoplasmic transportGO:19036491490.022
regulation of nuclear divisionGO:0051783650.022
regulation of mitotic sister chromatid separationGO:0010965270.021
regulation of proteolysisGO:00301622930.021
mitotic centrosome separationGO:000710010.021
response to radiationGO:00093141510.021
positive regulation of cell proliferationGO:00082843010.020
regulation of dna repairGO:0006282470.020
negative regulation of cellular protein metabolic processGO:00322693530.020
negative regulation of catabolic processGO:00098951040.020
dna packagingGO:0006323770.020
neuron differentiationGO:00301821380.020
positive regulation of cell deathGO:00109422630.019
regulation of metaphase anaphase transition of cell cycleGO:1902099260.019
chromatin assembly or disassemblyGO:0006333780.019
negative regulation of cell cycle phase transitionGO:1901988890.019
centrosome duplicationGO:0051298280.019
negative regulation of intracellular signal transductionGO:19025321830.019
regulation of cellular amino acid metabolic processGO:000652160.019
positive regulation of apoptotic processGO:00430652460.019
positive regulation of organelle organizationGO:00106381950.019
cell part morphogenesisGO:00329901370.019
Fly
positive regulation of cellular catabolic processGO:00313312840.018
oogenesisGO:004847720.018
regulation of microtubule based processGO:0032886740.018
negative regulation of proteolysisGO:00458611320.018
anatomical structure formation involved in morphogenesisGO:00486462840.018
Fly
positive regulation of neural precursor cell proliferationGO:200017920.018
positive regulation of dna metabolic processGO:0051054730.017
negative regulation of cell deathGO:00605483450.017
regulation of centrosome duplicationGO:0010824140.017
regulation of nucleocytoplasmic transportGO:0046822980.017
cellular ketone metabolic processGO:0042180800.017
macromolecular complex disassemblyGO:0032984600.017
neural tube closureGO:000184330.017
intracellular protein transportGO:00068862700.017
histone acetylationGO:0016573930.017
regulation of cellular ketone metabolic processGO:0010565500.017
regulation of nucleotide metabolic processGO:00061402690.016
negative regulation of protein phosphorylationGO:00019331400.016
protein autophosphorylationGO:00467771230.016
Fly
negative regulation of catalytic activityGO:00430863350.016
response to oxidative stressGO:00069791210.016
positive regulation of cellular component organizationGO:00511303760.016
negative regulation of phosphate metabolic processGO:00459362670.016
regulation of proteolysis involved in cellular protein catabolic processGO:1903050910.016
reproductive processGO:00224141060.016
Mouse Fly
positive regulation of catabolic processGO:00098963100.015
Fly
epithelium developmentGO:00604292270.015
cell morphogenesisGO:00009022960.015
Fly
positive regulation of programmed cell deathGO:00430682490.015
cellular protein complex assemblyGO:00436231880.015
regulation of cellular amine metabolic processGO:0033238110.015
protein importGO:00170381300.015
signal transduction by phosphorylationGO:00230142970.015
sister chromatid cohesionGO:0007062240.015
negative regulation of proteolysis involved in cellular protein catabolic processGO:1903051350.014
maintenance of protein location in cellGO:0032507560.014
negative regulation of meiotic cell cycleGO:005144720.014
negative regulation of protein processingGO:00109551420.014
negative regulation of transferase activityGO:00513481240.014
regulation of organelle assemblyGO:1902115400.014
negative regulation of protein catabolic processGO:0042177590.014
neuron developmentGO:00486661130.014
centrosome separationGO:005129930.014
regulation of nucleotide catabolic processGO:00308112050.013
positive regulation of transportGO:00510503360.013
regulation of chromosome organizationGO:00330441030.013
internal peptidyl lysine acetylationGO:0018393970.013
regulation of neural precursor cell proliferationGO:200017740.013
regulation of intracellular transportGO:00323861950.013
primary neural tube formationGO:001402030.013
axoneme assemblyGO:003508230.013
Fly
attachment of mitotic spindle microtubules to kinetochoreGO:005131530.013
protein polyubiquitinationGO:00002091100.013
positive regulation of developmental processGO:00510943140.013
response to abiotic stimulusGO:00096283360.012
regulation of protein transportGO:00512232130.012
regulation of centrosome cycleGO:0046605150.012
cell activationGO:00017752130.012
regulation of mitotic cell cycle phase transitionGO:19019901180.012
regulation of dna replicationGO:0006275680.012
protein maturationGO:00516042330.012
regulation of cell morphogenesisGO:00226041530.012
positive regulation of nucleoside metabolic processGO:00459791860.012
regulation of meiotic cell cycleGO:005144540.012
positive regulation of nucleotide metabolic processGO:00459812300.012
generation of neuronsGO:00486991520.012
positive regulation of gtp catabolic processGO:00331261660.012
cellular response to radiationGO:0071478650.012
cell fate commitmentGO:0045165270.012
cilium organizationGO:0044782680.012
Fly
negative regulation of protein modification processGO:00314002000.012
recombinational repairGO:0000725500.012
negative regulation of cellular protein catabolic processGO:1903363380.012
organelle localizationGO:0051640840.012
cell projection organizationGO:00300302520.012
Fly
positive regulation of protein transportGO:00512221350.012
reciprocal dna recombinationGO:003582540.011
negative regulation of protein maturationGO:19033181420.011
reproductive system developmentGO:0061458560.011
Mouse
tissue regenerationGO:004224630.011
developmental process involved in reproductionGO:0003006660.011
Mouse Fly
negative regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032435300.011
spindle assembly involved in mitosisGO:0090307120.011
positive regulation of cytoplasmic transportGO:1903651820.011
cytoplasmic transportGO:00164823790.011
protein targetingGO:00066051870.011
reciprocal meiotic recombinationGO:000713140.010
positive regulation of intracellular transportGO:00323881040.010
regulation of intracellular protein transportGO:00331571230.010
wnt signaling pathwayGO:00160551560.010
tissue morphogenesisGO:0048729960.010
determination of adult lifespanGO:000834020.010
regulation of apoptotic signaling pathwayGO:20012331750.010
biological adhesionGO:00226103310.010
embryonic organ developmentGO:0048568360.010
Mouse
negative regulation of mitotic sister chromatid separationGO:2000816170.010

PLK4 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
physical disorderDOID:0080015410.048
congenital nervous system abnormalityDOID:2490210.048
immune system diseaseDOID:29141550.023
disease of cellular proliferationDOID:145661740.014