Homo sapiens

24 known processes

SHANK2

SH3 and multiple ankyrin repeat domains 2

(Aliases: SHANK,ProSAP1,CORTBP1,CTTNBP1,SPANK-3,AUTS17)

SHANK2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of cellular amine metabolic processGO:0033238110.332
inorganic cation transmembrane transportGO:00986621940.247
post embryonic developmentGO:000979120.216
regulation of cellular amino acid metabolic processGO:000652160.215
epithelium developmentGO:00604292270.198
regulation of cell differentiationGO:00455953930.190
positive regulation of cellular component movementGO:00512721810.183
cellular amino acid metabolic processGO:00065201160.181
gtp catabolic processGO:00061842370.180
regulation of cellular component movementGO:00512703340.175
positive regulation of hydrolase activityGO:00513453310.166
purine containing compound catabolic processGO:00725234110.161
endodermal cell fate commitmentGO:000171140.161
regulation of cellular ketone metabolic processGO:0010565500.159
positive regulation of cellular amine metabolic processGO:003324070.158
purine ribonucleoside triphosphate catabolic processGO:00092073910.153
small gtpase mediated signal transductionGO:0007264780.153
system processGO:00030083490.153
purine nucleotide catabolic processGO:00061954050.151
nucleoside triphosphate catabolic processGO:00091433940.149
ras protein signal transductionGO:0007265730.145
nucleoside catabolic processGO:00091644080.143
behaviorGO:00076101120.140
gtp metabolic processGO:00460392390.135
cell morphogenesisGO:00009022960.135
regulation of cell motilityGO:20001452990.134
epithelial cell differentiationGO:00308551410.132
purine nucleoside triphosphate catabolic processGO:00091463920.131
positive regulation of cellular amino acid metabolic processGO:004576430.127
nucleoside triphosphate metabolic processGO:00091414220.127
ribonucleoside triphosphate metabolic processGO:00091994120.127
regulation of cell migrationGO:00303342890.126
metal ion homeostasisGO:00550651690.125
cation transmembrane transportGO:00986552380.125
ion transmembrane transportGO:00342203380.124
locomotory behaviorGO:000762610.124
nucleotide catabolic processGO:00091664080.123
regulation of gtp catabolic processGO:00331241800.123
positive regulation of cell motilityGO:20001471770.121
positive regulation of ras gtpase activityGO:00323201170.121
rho protein signal transductionGO:0007266260.116
nervous system developmentGO:00073992930.115
Mouse Rat
positive regulation of locomotionGO:00400171860.111
cell adhesionGO:00071553250.109
actin filament based processGO:00300292240.108
positive regulation of nucleotide catabolic processGO:00308131850.107
signal transduction by phosphorylationGO:00230142970.107
purine ribonucleotide catabolic processGO:00091544040.107
ribonucleotide catabolic processGO:00092614050.105
positive regulation of developmental processGO:00510943140.104
nucleoside phosphate catabolic processGO:19012924120.104
amine metabolic processGO:0009308440.104
mapk cascadeGO:00001652880.104
regulation of hormone levelsGO:00108171250.103
purine ribonucleoside triphosphate metabolic processGO:00092054110.103
purine ribonucleoside metabolic processGO:00461284370.103
ribonucleoside triphosphate catabolic processGO:00092033910.103
regulation of nucleotide catabolic processGO:00308112050.102
positive regulation of cellular catabolic processGO:00313312840.100
guanosine containing compound catabolic processGO:19010692390.099
negative regulation of cell deathGO:00605483450.097
regulation of nucleoside metabolic processGO:00091182090.096
cellular component morphogenesisGO:00329893140.096
glycosyl compound catabolic processGO:19016584130.096
cell projection morphogenesisGO:00488581290.094
nerve developmentGO:002167540.093
regulation of purine nucleotide metabolic processGO:19005422640.093
purine nucleoside triphosphate metabolic processGO:00091444120.089
purine ribonucleoside catabolic processGO:00461303980.087
regulation of purine nucleotide catabolic processGO:00331212050.084
enzyme linked receptor protein signaling pathwayGO:00071673030.084
organophosphate catabolic processGO:00464344300.084
cellular amine metabolic processGO:0044106410.084
positive regulation of gtp catabolic processGO:00331261660.083
positive regulation of purine nucleotide catabolic processGO:00331231850.080
memoryGO:000761330.080
Mouse
cardiovascular system developmentGO:00723582620.079
response to abiotic stimulusGO:00096283360.079
transmembrane transportGO:00550853990.078
second messenger mediated signalingGO:0019932780.077
purine nucleoside catabolic processGO:00061523980.077
positive regulation of phosphorylationGO:00423273940.076
cell developmentGO:00484683280.076
regulation of nucleotide metabolic processGO:00061402690.076
positive regulation of catabolic processGO:00098963100.075
regulation of ras protein signal transductionGO:00465781550.074
anatomical structure formation involved in morphogenesisGO:00486462840.074
positive regulation of nucleoside metabolic processGO:00459791860.073
female gamete generationGO:000729220.071
positive regulation of gtpase activityGO:00435471660.071
positive regulation of nucleotide metabolic processGO:00459812300.070
positive regulation of cell migrationGO:00303351720.070
cell cell signalingGO:00072671550.068
Mouse
organ morphogenesisGO:00098871470.068
regulation of ras gtpase activityGO:00323181280.066
negative regulation of apoptotic processGO:00430663160.065
segmentationGO:003528240.064
morphogenesis of embryonic epitheliumGO:001633140.064
ion homeostasisGO:00508012300.062
regulation of proteolysisGO:00301622930.062
neuromuscular junction developmentGO:000752830.062
cell projection organizationGO:00300302520.061
cellular ketone metabolic processGO:0042180800.061
peptidyl tyrosine phosphorylationGO:00181081700.060
regulation of anatomical structure morphogenesisGO:00226032860.060
ribonucleoside catabolic processGO:00424544060.060
positive regulation of purine nucleotide metabolic processGO:19005442270.059
cell fate determinationGO:000170930.059
positive regulation of cellular component organizationGO:00511303760.059
regulation of cellular response to stressGO:00801352440.058
negative regulation of phosphate metabolic processGO:00459362670.058
negative regulation of developmental processGO:00510932470.058
positive regulation of mapk cascadeGO:00434101900.056
regulation of actin filament based processGO:00329701410.056
tube morphogenesisGO:0035239950.056
regenerationGO:003109940.056
positive regulation of cell differentiationGO:00455972110.056
tissue morphogenesisGO:0048729960.055
forebrain generation of neuronsGO:002187230.055
single organism cell adhesionGO:00986021790.055
cellular ion homeostasisGO:00068731680.054
protein catabolic processGO:00301633250.054
regulation of cellular component biogenesisGO:00440872810.053
regulation of gtpase activityGO:00430871800.053
inorganic ion transmembrane transportGO:00986602310.053
cytoplasmic transportGO:00164823790.052
regulation of locomotionGO:00400123290.052
cellular macromolecule catabolic processGO:00442653800.051
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.051
cellular response to growth factor stimulusGO:00713631970.051
divalent inorganic cation homeostasisGO:00725071360.051
positive regulation of protein phosphorylationGO:00019343130.050
biological adhesionGO:00226103310.050
neurogenesisGO:00220081690.049
oogenesisGO:004847720.048
metal ion transportGO:00300012720.048
regulation of mapk cascadeGO:00434082620.048
cranial nerve developmentGO:002154540.048
intracellular protein transportGO:00068862700.047
tube developmentGO:00352951250.047
cellular response to oxygen containing compoundGO:19017012760.047
regulation of small gtpase mediated signal transductionGO:00510561560.046
regulation of mitotic cell cycleGO:00073461890.046
mitotic cell cycle processGO:19030472860.046
digestive system developmentGO:0055123750.045
secretionGO:00469032540.045
peripheral nervous system developmentGO:000742220.045
cation transportGO:00068123310.045
chemical homeostasisGO:00488783060.044
microtubule based processGO:00070172100.044
single organismal cell cell adhesionGO:00163371480.044
neuron projection developmentGO:00311751060.044
guanosine containing compound metabolic processGO:19010682440.043
cellular response to endogenous stimulusGO:00714953360.043
regulation of growthGO:00400081650.043
muscle structure developmentGO:0061061980.042
compound eye developmentGO:004874910.042
negative regulation of cell cycleGO:00457861930.042
cation homeostasisGO:00550801890.042
forebrain neuron differentiationGO:002187930.042
monovalent inorganic cation transportGO:00156721280.042
actin cytoskeleton organizationGO:00300362070.042
regulation of transferase activityGO:00513383550.041
negative regulation of transportGO:00510511760.040
regulation of intracellular transportGO:00323861950.040
mitotic cell cycleGO:00002783260.040
regulation of cell cycleGO:00517263930.040
growthGO:00400072020.040
regulation of secretion by cellGO:19035301770.040
calcium ion homeostasisGO:00550741220.039
nitrogen compound transportGO:00717051910.039
positive regulation of proteolysisGO:00458621420.039
regulation of cell developmentGO:00602841610.039
circadian behaviorGO:004851220.038
regulation of cell growthGO:00015581350.038
endodermal cell fate specificationGO:000171440.038
negative regulation of programmed cell deathGO:00430693210.038
immune system developmentGO:00025201950.038
positive regulation of protein kinase activityGO:00458601900.038
regulation of ion transportGO:00432691890.038
small molecule biosynthetic processGO:00442831570.038
response to growth factorGO:00708482050.037
regulation of protein serine threonine kinase activityGO:00719001790.037
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.037
cell substrate adhesionGO:00315891320.037
cell part morphogenesisGO:00329901370.036
circulatory system developmentGO:00723592620.036
peptidyl tyrosine modificationGO:00182121700.036
organic hydroxy compound metabolic processGO:19016151470.036
embryonic epithelial tube formationGO:000183840.036
protein autophosphorylationGO:00467771230.036
blood vessel developmentGO:00015681720.036
vasculature developmentGO:00019441810.035
positive regulation of intracellular transportGO:00323881040.035
regulation of epithelial cell migrationGO:0010632930.034
response to lipidGO:00339932060.034
regulation of body fluid levelsGO:0050878990.034
regulation of protein catabolic processGO:00421761550.033
negative regulation of phosphorus metabolic processGO:00105632670.033
wnt signaling pathwayGO:00160551560.033
oocyte differentiationGO:000999420.033
ameboidal type cell migrationGO:00016671350.033
sequestering of metal ionGO:0051238240.033
neural crest cell developmentGO:001403230.033
digestive tract developmentGO:0048565750.033
regulation of peptidyl tyrosine phosphorylationGO:00507301080.032
extrinsic apoptotic signaling pathwayGO:00971911190.032
regulation of cell morphogenesis involved in differentiationGO:0010769830.032
regulation of intracellular protein transportGO:00331571230.031
response to oxygen containing compoundGO:19017003690.031
cellular metal ion homeostasisGO:00068751460.031
blood vessel morphogenesisGO:00485141620.031
cellular response to cytokine stimulusGO:00713451810.031
cellular macromolecular complex assemblyGO:00346223240.031
regulation of cytoplasmic transportGO:19036491490.031
response to cytokineGO:00340972320.031
regulation of peptidase activityGO:00525471800.031
regulation of protein transportGO:00512232130.031
apoptotic signaling pathwayGO:00971902680.030
cell projection assemblyGO:00300311260.030
positive regulation of transportGO:00510503360.030
positive regulation of programmed cell deathGO:00430682490.030
positive regulation of cell deathGO:00109422630.030
synaptic transmissionGO:0007268610.030
Mouse
embryo developmentGO:00097901230.030
regulation of cell adhesionGO:00301551660.030
single organism reproductive processGO:0044702980.029
epithelial cell proliferationGO:00506731280.029
stress activated protein kinase signaling cascadeGO:0031098940.029
reactive oxygen species metabolic processGO:0072593750.029
blastoderm segmentationGO:000735020.029
epithelial cell migrationGO:00106311190.029
regulation of membrane potentialGO:0042391950.029
motor neuron axon guidanceGO:000804520.029
immune responseGO:00069553070.028
regulation of epithelial cell proliferationGO:00506781130.028
regulation of cytoskeleton organizationGO:00514931770.028
cellular homeostasisGO:00197251960.028
establishment or maintenance of bipolar cell polarityGO:006124520.028
regulation of kinase activityGO:00435493140.027
stem cell differentiationGO:0048863930.027
wound healingGO:00420601150.027
positive regulation of protein transportGO:00512221350.027
membrane organizationGO:00610242920.027
regulation of sequence specific dna binding transcription factor activityGO:00510902110.027
generation of neuronsGO:00486991520.027
photoreceptor cell differentiationGO:004653020.027
positive regulation of cytoplasmic transportGO:1903651820.027
positive regulation of protein serine threonine kinase activityGO:00719021190.027
regulation of jnk cascadeGO:0046328730.027
male genitalia developmentGO:003053910.027
microtubule cytoskeleton organizationGO:00002261760.027
negative regulation of catalytic activityGO:00430863350.027
regulation of cell cycle phase transitionGO:19019871260.027
lipid metabolic processGO:00066293810.027
regulation of transmembrane transportGO:00347621390.027
sequestering of calcium ionGO:0051208170.026
regulation of rho gtpase activityGO:0032319660.026
hematopoietic or lymphoid organ developmentGO:00485341860.026
multicellular organismal agingGO:001025930.026
vesicle mediated transportGO:00161923710.026
organophosphate biosynthetic processGO:00904071630.026
actin filament organizationGO:00070151280.026
cell cycle phase transitionGO:00447701730.026
regulation of cell morphogenesisGO:00226041530.026
tissue regenerationGO:004224630.026
negative regulation of cell differentiationGO:00455961710.026
phosphatidylinositol mediated signalingGO:0048015550.026
multicellular organismal homeostasisGO:0048871670.026
oocyte developmentGO:004859910.026
carbohydrate derivative biosynthetic processGO:19011372070.026
associative learningGO:000830610.025
divalent metal ion transportGO:00708381520.025
cell morphogenesis involved in differentiationGO:00009041440.025
negative regulation of hydrolase activityGO:00513461820.025
regulation of nervous system developmentGO:0051960880.025
regulation of protein localizationGO:00328802960.025
cellular cation homeostasisGO:00300031630.025
positive regulation of cellular component biogenesisGO:00440891580.025
mesenchymal cell developmentGO:0014031500.025
cellular lipid metabolic processGO:00442553030.024
proteolysis involved in cellular protein catabolic processGO:00516032440.024
response to hormoneGO:00097251750.024
negative regulation of cell proliferationGO:00082852280.024
cellular response to lipidGO:00713961270.024
morphogenesis of an epitheliumGO:0002009600.024
angiogenesisGO:00015251470.024
endodermal cell differentiationGO:0035987310.024
response to woundingGO:00096111680.024
jnk cascadeGO:0007254800.024
response to nitrogen compoundGO:19016981840.024
regulation of apoptotic signaling pathwayGO:20012331750.024
regulation of wnt signaling pathwayGO:00301111230.024
secretion by cellGO:00329402260.024
positive regulation of kinase activityGO:00336742040.023
taxisGO:00423301570.023
reproductive processGO:00224141060.023
organic hydroxy compound biosynthetic processGO:1901617710.023
central nervous system developmentGO:00074171230.023
Rat
organelle assemblyGO:00709251760.023
skin developmentGO:0043588760.023
proteasomal protein catabolic processGO:00104981760.023
ossificationGO:00015031210.023
phospholipid metabolic processGO:0006644990.023
glial cell migrationGO:000834740.023
response to oxidative stressGO:00069791210.023
positive regulation of map kinase activityGO:0043406800.023
protein ubiquitinationGO:00165673140.023
neuroblast proliferationGO:000740540.022
response to organic cyclic compoundGO:00140702040.022
endomembrane system organizationGO:00102561960.022
neural crest cell migrationGO:000175520.022
negative regulation of mitotic cell cycleGO:00459301020.022
chordate embryonic developmentGO:0043009340.022
activation of protein kinase activityGO:0032147900.022
posttranscriptional regulation of gene expressionGO:00106082130.022
neurotransmitter secretionGO:000726940.022
lipid biosynthetic processGO:00086101770.022
positive regulation of secretion by cellGO:19035321080.022
protein localization to organelleGO:00333652800.022
regulation of neuron differentiationGO:0045664700.022
single organism cellular localizationGO:19025803320.022
negative regulation of cellular component organizationGO:00511292350.022
cellular potassium ion transportGO:0071804600.022
regulation of cell cycle processGO:00105642660.022
regulation of establishment of protein localizationGO:00702012420.022
alcohol metabolic processGO:00060661140.021
cell type specific apoptotic processGO:00972851250.021
neuron fate commitmentGO:004866320.021
dephosphorylationGO:00163112090.021
erk1 and erk2 cascadeGO:00703711040.021
circulatory system processGO:00030131130.021
regulation of protein kinase activityGO:00458592890.021
positive regulation of erk1 and erk2 cascadeGO:0070374750.021
single organism membrane organizationGO:00448022680.021
protein processingGO:00164852260.021
spermatid differentiationGO:004851540.021
mesenchyme developmentGO:0060485590.021
regulation of stress activated mapk cascadeGO:0032872840.021
epithelium migrationGO:00901321190.021
negative regulation of cell migrationGO:00303361020.021
positive regulation of apoptotic processGO:00430652460.021
glycerolipid metabolic processGO:00464861070.021
protein localization to nucleusGO:00345041360.021
renal system developmentGO:0072001630.021
endothelial cell migrationGO:0043542860.020
regulation of neurogenesisGO:0050767820.020
determination of adult lifespanGO:000834020.020
neuron developmentGO:00486661130.020
cellular response to dna damage stimulusGO:00069743790.020
maintenance of locationGO:00512351120.020
regulation of actin cytoskeleton organizationGO:00329561160.020
anatomical structure homeostasisGO:00602491000.020
chromatin modificationGO:00165682980.020
neuron differentiationGO:00301821380.020
canonical wnt signaling pathwayGO:00600701160.020
cytosolic calcium ion homeostasisGO:0051480890.020
actin filament based movementGO:0030048170.020
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.020
regulation of cell projection organizationGO:00313441070.019
leukocyte activationGO:00453211640.019
negative regulation of wnt signaling pathwayGO:0030178690.019
digestive tract morphogenesisGO:0048546560.019
neural tube formationGO:000184130.019
morphogenesis of a polarized epitheliumGO:000173830.019
innate immune responseGO:00450871780.019
stem cell developmentGO:0048864690.019
cyclic nucleotide metabolic processGO:0009187820.019
regulation of erk1 and erk2 cascadeGO:0070372990.019
endocrine system developmentGO:0035270260.019
negative regulation of intracellular signal transductionGO:19025321830.019
sensory organ developmentGO:0007423520.019
divalent inorganic cation transportGO:00725111580.019
cell junction organizationGO:0034330790.019
negative regulation of multicellular organismal processGO:00512413170.019
regulation of secretionGO:00510461940.019
regulation of mitotic cell cycle phase transitionGO:19019901180.019
regulation of behaviorGO:0050795820.019
cell cell junction organizationGO:0045216690.019
positive regulation of cell developmentGO:0010720920.018
mesodermal cell fate commitmentGO:000171020.018
negative regulation of protein metabolic processGO:00512483910.018
hemopoiesisGO:00300971800.018
negative regulation of cellular protein metabolic processGO:00322693530.018
cilium morphogenesisGO:0060271750.018
positive regulation of cell cycleGO:00457871400.018
cell growthGO:00160491600.018
cell matrix adhesionGO:0007160850.018
defense responseGO:00069523150.018
regulation of ion transmembrane transporter activityGO:0032412720.018
cellular divalent inorganic cation homeostasisGO:00725031280.018
hormone transportGO:0009914680.018
cellular protein complex assemblyGO:00436231880.018
limb bud formationGO:006017410.018
negative regulation of cell growthGO:0030308830.018
cell activationGO:00017752130.018
sex determinationGO:000753030.018
inner ear morphogenesisGO:004247240.018
tissue migrationGO:00901301190.018
positive regulation of neurogenesisGO:0050769490.018
salivary gland morphogenesisGO:000743540.018
regulation of endopeptidase activityGO:00525481700.018
mitotic cell cycle phase transitionGO:00447721620.018
regulation of dephosphorylationGO:0035303960.018
positive regulation of dna metabolic processGO:0051054730.018
nucleocytoplasmic transportGO:00069131760.017
negative regulation of growthGO:0045926970.017
response to transforming growth factor betaGO:0071559940.017
negative regulation of apoptotic signaling pathwayGO:2001234970.017
epidermis developmentGO:0008544590.017
regulation of ion homeostasisGO:2000021730.017
regulation of proteasomal protein catabolic processGO:0061136870.017
muscle cell fate commitmentGO:004269340.017
gastrulationGO:0007369510.017
neurological system processGO:00508771630.017
positive regulation of cytokine productionGO:00018191670.017
regulation of neuron projection developmentGO:0010975570.017
adult locomotory behaviorGO:000834410.017
peptidyl serine modificationGO:00182091060.017
endoderm developmentGO:0007492330.017
eye photoreceptor cell differentiationGO:000175420.017
gland developmentGO:0048732480.017
glycerolipid biosynthetic processGO:0045017510.017
positive regulation of endopeptidase activityGO:0010950840.017
regulation of vesicle mediated transportGO:00606271300.017
soft palate developmentGO:006002330.017
negative regulation of locomotionGO:00400131180.017
regulation of cysteine type endopeptidase activityGO:20001161270.017
action potentialGO:0001508340.017
endoderm formationGO:0001706330.016
regulation of endothelial cell migrationGO:0010594670.016
regulation of map kinase activityGO:00434051080.016
negative regulation of protein modification processGO:00314002000.016
positive regulation of transferase activityGO:00513472270.016
regulation of reactive oxygen species biosynthetic processGO:190342630.016
eye developmentGO:0001654420.016
response to acid chemicalGO:0001101660.016
carbohydrate metabolic processGO:00059752070.016
regulation of phosphatase activityGO:0010921810.016
response to biotic stimulusGO:00096072760.016
protein importGO:00170381300.016
reproductive system developmentGO:0061458560.016
peptidyl serine phosphorylationGO:00181051010.016
osteoblast differentiationGO:0001649920.016
cellular protein catabolic processGO:00442572610.016
negative regulation of cell cycle phase transitionGO:1901988890.016
plasma membrane organizationGO:00070091150.016
negative regulation of cell motilityGO:20001461040.016
transforming growth factor beta receptor signaling pathwayGO:0007179760.016
regulation of dna metabolic processGO:00510521530.016
regulation of calcium ion transport into cytosolGO:0010522330.016
cellular response to nitrogen compoundGO:19016991440.016
tissue homeostasisGO:0001894630.016
hormone metabolic processGO:0042445610.016
regulation of bindingGO:00510981110.016
regulation of male gonad developmentGO:200001840.016
regulation of anatomical structure sizeGO:00900661010.016
single organism carbohydrate metabolic processGO:00447231930.016
regulation of cardiac muscle cell proliferationGO:006004340.016
head developmentGO:00603221080.016
Rat
signal releaseGO:0023061700.015
cellular calcium ion homeostasisGO:00068741170.015
positive regulation of epithelial cell proliferationGO:0050679650.015
cell cycle g1 s phase transitionGO:0044843800.015
regulation of cytokine productionGO:00018172320.015
epithelial cell developmentGO:0002064340.015
response to other organismGO:00517072610.015
mitochondrion organizationGO:00070051560.015
reactive nitrogen species metabolic processGO:200105730.015
negative regulation of gliogenesisGO:001401430.015
negative regulation of cell adhesionGO:0007162640.015
cellular response to transforming growth factor beta stimulusGO:0071560940.015
kidney developmentGO:0001822530.015
hindbrain developmentGO:003090230.015
reactive oxygen species biosynthetic processGO:190340940.015
g1 s transition of mitotic cell cycleGO:0000082780.015
regulation of camp biosynthetic processGO:0030817450.015
pattern specification processGO:0007389430.015
protein modification by small protein conjugationGO:00324463420.015
positive regulation of rho gtpase activityGO:0032321560.015
dendritic spine morphogenesisGO:006099730.015
developmental process involved in reproductionGO:0003006660.015

SHANK2 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:145661740.036
cancerDOID:1621670.028
organ system cancerDOID:00506861640.024
nervous system diseaseDOID:8634310.022
sensory system diseaseDOID:00501552030.022
musculoskeletal system diseaseDOID:172230.018
connective tissue diseaseDOID:651090.018
central nervous system diseaseDOID:3311860.017
neurodegenerative diseaseDOID:12891020.017
disease of metabolismDOID:00146672950.015
bone diseaseDOID:0080001880.015