Homo sapiens

80 known processes

HSPA5

heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)

(Aliases: MIF2,GRP78,BIP,FLJ26106)

HSPA5 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
response to unfolded proteinGO:0006986241.000
Yeast Mouse Worm
cellular response to unfolded proteinGO:0034620161.000
Mouse Worm
er nucleus signaling pathwayGO:0006984230.999
Mouse Worm
endoplasmic reticulum unfolded protein responseGO:0030968160.999
Mouse Worm
proteolysis involved in cellular protein catabolic processGO:00516032440.991
Yeast Mouse
modification dependent macromolecule catabolic processGO:00436322120.990
Yeast
cellular protein catabolic processGO:00442572610.989
Yeast Mouse
ubiquitin dependent protein catabolic processGO:00065112060.981
Yeast
cellular response to topologically incorrect proteinGO:0035967190.967
Mouse Worm
protein catabolic processGO:00301633250.962
Yeast Mouse
nucleoside catabolic processGO:00091644080.955
Yeast
nucleoside triphosphate metabolic processGO:00091414220.950
Yeast
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.946
Yeast
response to endoplasmic reticulum stressGO:0034976490.941
Mouse Rat Worm
modification dependent protein catabolic processGO:00199412090.915
Yeast
proteasomal protein catabolic processGO:00104981760.890
Yeast
purine nucleoside catabolic processGO:00061523980.872
Yeast
endoplasmic reticulum organizationGO:0007029200.809
intracellular protein transmembrane transportGO:0065002240.785
Yeast
post embryonic developmentGO:000979120.770
Worm
protein foldingGO:0006457380.740
negative regulation of programmed cell deathGO:00430693210.724
negative regulation of cell deathGO:00605483450.720
response to topologically incorrect proteinGO:0035966290.692
Yeast Mouse Worm
response to abiotic stimulusGO:00096283360.690
cellular macromolecule catabolic processGO:00442653800.685
Yeast Mouse
cytoplasmic transportGO:00164823790.679
Yeast
er associated ubiquitin dependent protein catabolic processGO:0030433310.640
Yeast
nucleotide catabolic processGO:00091664080.632
Yeast
positive regulation of catabolic processGO:00098963100.618
ribonucleotide catabolic processGO:00092614050.610
Yeast
apoptotic signaling pathwayGO:00971902680.600
protein transmembrane transportGO:0071806250.587
Yeast
negative regulation of protein metabolic processGO:00512483910.577
cellular response to organonitrogen compoundGO:00714171240.576
membrane organizationGO:00610242920.537
Yeast
multicellular organismal agingGO:001025930.526
regulation of atpase activityGO:0043462250.519
nucleoside phosphate catabolic processGO:19012924120.509
Yeast
regulation of cellular response to stressGO:00801352440.488
vesicle mediated transportGO:00161923710.482
purine ribonucleotide catabolic processGO:00091544040.457
Yeast
enzyme linked receptor protein signaling pathwayGO:00071673030.455
Mouse
purine ribonucleoside catabolic processGO:00461303980.437
Yeast
positive regulation of cellular catabolic processGO:00313312840.426
purine ribonucleoside metabolic processGO:00461284370.424
Yeast
purine ribonucleoside triphosphate catabolic processGO:00092073910.393
Yeast
determination of adult lifespanGO:000834020.354
positive regulation of hydrolase activityGO:00513453310.349
Mouse
response to oxygen levelsGO:00704821000.333
response to nitrogen compoundGO:19016981840.327
organophosphate catabolic processGO:00464344300.324
Yeast
purine ribonucleoside triphosphate metabolic processGO:00092054110.316
Yeast
negative regulation of apoptotic processGO:00430663160.315
glycosyl compound catabolic processGO:19016584130.312
Yeast
actin filament based processGO:00300292240.294
positive regulation of purine nucleotide metabolic processGO:19005442270.290
response to axon injuryGO:004867810.289
purine containing compound catabolic processGO:00725234110.285
Yeast
regulation of nucleoside metabolic processGO:00091182090.276
response to hypoxiaGO:0001666960.271
regulation of purine nucleotide metabolic processGO:19005422640.270
gtp catabolic processGO:00061842370.252
actin filament organizationGO:00070151280.245
ribonucleoside triphosphate metabolic processGO:00091994120.245
Yeast
response to oxygen containing compoundGO:19017003690.243
nucleoside triphosphate catabolic processGO:00091433940.240
Yeast
positive regulation of developmental processGO:00510943140.239
system processGO:00030083490.233
leukocyte activationGO:00453211640.224
nervous system developmentGO:00073992930.221
autophagyGO:0006914880.218
ribonucleoside triphosphate catabolic processGO:00092033910.214
Yeast
protein localization to organelleGO:00333652800.214
lipid localizationGO:00108761060.213
Worm
positive regulation of immune system processGO:00026842830.212
intrinsic apoptotic signaling pathwayGO:00971931270.205
purine nucleotide catabolic processGO:00061954050.204
Yeast
response to decreased oxygen levelsGO:0036293960.196
establishment of protein localization to organelleGO:00725941720.195
Yeast
regulation of purine nucleotide catabolic processGO:00331212050.193
regulation of growthGO:00400081650.188
positive regulation of nucleotide catabolic processGO:00308131850.188
chaperone mediated protein foldingGO:0061077130.180
single organism cellular localizationGO:19025803320.178
Yeast
purine nucleoside monophosphate metabolic processGO:00091261860.177
Yeast
intracellular protein transmembrane importGO:0044743230.172
endomembrane system organizationGO:00102561960.172
regulation of proteolysisGO:00301622930.171
response to organic cyclic compoundGO:00140702040.171
cellular response to nitrogen compoundGO:19016991440.168
purine nucleoside monophosphate catabolic processGO:00091281580.167
Yeast
negative regulation of intracellular signal transductionGO:19025321830.161
regulation of intrinsic apoptotic signaling pathwayGO:2001242720.160
transmembrane transportGO:00550853990.158
Yeast
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressGO:0070059120.157
negative regulation of cellular protein metabolic processGO:00322693530.156
establishment of protein localization to mitochondrionGO:0072655220.156
cellular response to organic cyclic compoundGO:00714071270.153
negative regulation of phosphorus metabolic processGO:00105632670.152
establishment of protein localization to membraneGO:00901501210.146
Yeast
ribonucleoside catabolic processGO:00424544060.145
Yeast
regulation of bindingGO:00510981110.140
negative regulation of phosphorylationGO:00423261740.137
growthGO:00400072020.135
positive regulation of nucleotide metabolic processGO:00459812300.135
cardiac muscle tissue developmentGO:0048738390.132
negative regulation of protein phosphorylationGO:00019331400.132
purine nucleoside triphosphate metabolic processGO:00091444120.132
Yeast
negative regulation of apoptotic signaling pathwayGO:2001234970.127
positive regulation of blood pressureGO:004577730.127
regulation of small gtpase mediated signal transductionGO:00510561560.124
regulation of atp metabolic processGO:1903578290.124
response to organophosphorusGO:0046683410.123
cellular potassium ion transportGO:0071804600.123
response to purine containing compoundGO:0014074400.123
regulation of nucleotide catabolic processGO:00308112050.117
regulation of cell differentiationGO:00455953930.114
cellular macromolecular complex assemblyGO:00346223240.114
ribonucleoside monophosphate catabolic processGO:00091581580.112
Yeast
immune responseGO:00069553070.111
regulation of apoptotic signaling pathwayGO:20012331750.110
circulatory system developmentGO:00723592620.110
protein targetingGO:00066051870.106
Yeast
purine nucleoside triphosphate catabolic processGO:00091463920.105
Yeast
activation of cysteine type endopeptidase activityGO:0097202570.105
lymphocyte activationGO:00466491330.104
response to organonitrogen compoundGO:00102431560.103
positive regulation of protein bindingGO:0032092240.099
regulation of translationGO:0006417890.095
response to woundingGO:00096111680.093
receptor mediated endocytosisGO:0006898840.092
immune response activating signal transductionGO:0002757900.091
regulation of cellular protein catabolic processGO:1903362960.090
guanosine containing compound catabolic processGO:19010692390.087
neurogenesisGO:00220081690.086
protein oligomerizationGO:00512591730.084
regulation of cellular amino acid metabolic processGO:000652160.083
vascular process in circulatory systemGO:0003018290.083
regulation of response to external stimulusGO:00321012220.083
golgi organizationGO:0007030380.082
secretionGO:00469032540.081
purine ribonucleoside monophosphate catabolic processGO:00091691580.081
Yeast
ion homeostasisGO:00508012300.080
cell developmentGO:00484683280.080
regulation of gtpase activityGO:00430871800.079
positive regulation of purine nucleotide catabolic processGO:00331231850.079
nucleocytoplasmic transportGO:00069131760.079
cell activationGO:00017752130.075
defense responseGO:00069523150.075
positive regulation of nucleoside metabolic processGO:00459791860.073
circulatory system processGO:00030131130.072
negative regulation of protein modification processGO:00314002000.071
embryo developmentGO:00097901230.069
Worm
maintenance of locationGO:00512351120.069
neurological system processGO:00508771630.068
reactive oxygen species metabolic processGO:0072593750.067
cellular homeostasisGO:00197251960.067
actin cytoskeleton organizationGO:00300362070.067
cellular ketone metabolic processGO:0042180800.066
regulation of membrane potentialGO:0042391950.066
positive regulation of immune responseGO:00507781590.065
cardiovascular system developmentGO:00723582620.065
regulation of t cell activationGO:0050863770.064
srp dependent cotranslational protein targeting to membraneGO:000661420.064
Yeast
cell cell signalingGO:00072671550.063
regulation of immune responseGO:00507762010.062
activation of cysteine type endopeptidase activity involved in apoptotic processGO:0006919490.062
protein targeting to membraneGO:0006612420.062
Yeast
regulation of cell activationGO:00508651250.061
positive regulation of protein catabolic processGO:0045732750.061
regenerationGO:003109940.060
generation of neuronsGO:00486991520.060
protein importGO:00170381300.059
regulation of protein catabolic processGO:00421761550.059
regulation of cellular component biogenesisGO:00440872810.058
agingGO:0007568660.058
intracellular protein transportGO:00068862700.057
Yeast
blood vessel developmentGO:00015681720.057
nucleoside monophosphate catabolic processGO:00091251590.056
Yeast
ribonucleoside monophosphate metabolic processGO:00091611870.056
Yeast
female gamete generationGO:000729220.055
regulation of lipid metabolic processGO:0019216960.055
regulation of dephosphorylationGO:0035303960.054
positive regulation of cell differentiationGO:00455972110.052
gtp metabolic processGO:00460392390.052
cellular response to oxygen levelsGO:0071453550.052
action potentialGO:0001508340.051
anterior posterior axis specificationGO:000994820.051
atp catabolic processGO:00062001570.050
Yeast
reproductive structure developmentGO:0048608550.050
posttranscriptional regulation of gene expressionGO:00106082130.050
Fly
hematopoietic or lymphoid organ developmentGO:00485341860.049
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.049
translationGO:00064121320.049
cellular amine metabolic processGO:0044106410.049
b cell activationGO:0042113330.048
negative regulation of phosphate metabolic processGO:00459362670.045
regulation of protein stabilityGO:0031647870.044
protein import into nucleusGO:00066061040.044
developmental growthGO:0048589480.044
mitotic cell cycleGO:00002783260.044
positive regulation of systemic arterial blood pressureGO:000308420.043
cell projection assemblyGO:00300311260.043
positive regulation of proteolysisGO:00458621420.043
ear developmentGO:0043583140.042
regulation of nucleotide metabolic processGO:00061402690.042
nucleoside monophosphate metabolic processGO:00091231910.042
Yeast
regulation of cell cycle processGO:00105642660.042
positive regulation of cellular protein catabolic processGO:1903364370.041
regulation of cell cycleGO:00517263930.039
cellular response to lipidGO:00713961270.039
neurotransmitter secretionGO:000726940.039
cell growthGO:00160491600.038
neuron differentiationGO:00301821380.038
protein localization to membraneGO:00726571600.037
Yeast
positive regulation of peptidase activityGO:0010952880.036
monocarboxylic acid metabolic processGO:00327871850.036
regulation of acute inflammatory response to antigenic stimulusGO:000286410.036
regulation of gtp catabolic processGO:00331241800.036
negative regulation of t cell receptor signaling pathwayGO:005086040.036
hemopoiesisGO:00300971800.035
positive regulation of programmed cell deathGO:00430682490.035
immune effector processGO:00022521590.035
positive regulation of extrinsic apoptotic signaling pathwayGO:2001238260.035
cellular response to growth factor stimulusGO:00713631970.034
Mouse
regulation of intracellular transportGO:00323861950.034
regulation of anatomical structure sizeGO:00900661010.034
response to starvationGO:0042594590.034
immune system developmentGO:00025201950.033
small gtpase mediated signal transductionGO:0007264780.033
regulation of locomotionGO:00400123290.033
response to oxidative stressGO:00069791210.033
protein refoldingGO:0042026140.033
sensory organ developmentGO:0007423520.033
metal ion transportGO:00300012720.033
response to lipidGO:00339932060.032
ras protein signal transductionGO:0007265730.032
cellular metal ion homeostasisGO:00068751460.032
protein ubiquitinationGO:00165673140.031
Mouse
chemical homeostasisGO:00488783060.031
single organism membrane organizationGO:00448022680.031
Yeast
cellular response to dna damage stimulusGO:00069743790.030
purine ribonucleoside monophosphate metabolic processGO:00091671860.030
Yeast
inner ear developmentGO:004883980.029
ossificationGO:00015031210.029
negative regulation of catalytic activityGO:00430863350.029
nuclear importGO:00511701060.028
regulation of vesicle mediated transportGO:00606271300.028
de novo protein foldingGO:000645820.028
protein modification by small protein conjugationGO:00324463420.028
Mouse
negative regulation of protein serine threonine kinase activityGO:0071901570.028
head developmentGO:00603221080.027
cellular response to oxygen containing compoundGO:19017012760.027
atp metabolic processGO:00460341760.027
Yeast
rac protein signal transductionGO:0016601120.027
dephosphorylationGO:00163112090.027
photoreceptor cell differentiationGO:004653020.027
sex differentiationGO:0007548450.027
negative regulation of cell differentiationGO:00455961710.027
regulation of blood vessel sizeGO:0050880180.027
cell morphogenesis involved in differentiationGO:00009041440.026
metencephalon developmentGO:002203720.026
Mouse
neuronal action potentialGO:001922890.025
positive regulation of growthGO:0045927580.025
oogenesisGO:004847720.025
regulation of meiotic cell cycleGO:005144540.025
positive regulation of gtp catabolic processGO:00331261660.025
male genitalia developmentGO:003053910.025
lactationGO:000759530.024
regulation of leukocyte activationGO:00026941150.024
activation of immune responseGO:00022531140.024
regulation of protein bindingGO:0043393660.024
protein targeting to erGO:004504770.023
Yeast
multicellular organismal reproductive processGO:0048609400.023
protein targeting to mitochondrionGO:0006626190.023
protein stabilizationGO:0050821640.023
establishment of organelle localizationGO:0051656590.023
positive regulation of phosphorylationGO:00423273940.023
Mouse
negative regulation of nitric oxide synthase biosynthetic processGO:005177130.023
potassium ion transportGO:0006813620.022
cellular response to decreased oxygen levelsGO:0036294510.022
signal releaseGO:0023061700.022
potassium ion transmembrane transportGO:0071805600.022
mitochondrion organizationGO:00070051560.022
eye pigmentationGO:004806910.022
t cell activationGO:0042110990.022
regulation of cellular carbohydrate metabolic processGO:0010675470.022
positive regulation of organelle organizationGO:00106381950.022
cytokine productionGO:00018162470.022
leukocyte differentiationGO:0002521980.022
blood circulationGO:00080151130.022
regulation of cell migrationGO:00303342890.021
reproductionGO:0000003630.021
Yeast Worm
cell projection organizationGO:00300302520.021
regulation of cytoskeleton organizationGO:00514931770.021
tissue regenerationGO:004224630.021
regulation of cell morphogenesisGO:00226041530.021
visual behaviorGO:000763220.021
regulation of protein transportGO:00512232130.021
blood vessel morphogenesisGO:00485141620.021
positive regulation of cell developmentGO:0010720920.021
cytokinesisGO:0000910960.021
cellular amino acid metabolic processGO:00065201160.021
cell cycle phase transitionGO:00447701730.020
regulation of reactive oxygen species metabolic processGO:2000377410.020
regulation of metal ion transportGO:00109591200.020
cellular response to endogenous stimulusGO:00714953360.020
Mouse
regulation of ras protein signal transductionGO:00465781550.020
positive regulation of apoptotic signaling pathwayGO:2001235700.020
response to inorganic substanceGO:00100351270.020
embryonic placenta developmentGO:000189210.020
inclusion body assemblyGO:0070841170.020
lymphocyte differentiationGO:0030098350.020
regulation of defense responseGO:00313471540.019
regulation of behaviorGO:0050795820.019
vasculature developmentGO:00019441810.019
mitotic cell cycle phase transitionGO:00447721620.019
spermatid differentiationGO:004851540.019
mononuclear cell proliferationGO:0032943710.019
single organism carbohydrate metabolic processGO:00447231930.019
positive regulation of ras gtpase activityGO:00323201170.018
inflammatory responseGO:0006954790.018
nuclear transportGO:00511691790.018
positive regulation of bindingGO:0051099450.018
somitogenesisGO:000175620.018
neuron projection developmentGO:00311751060.018
protein autophosphorylationGO:00467771230.018
negative regulation of response to external stimulusGO:0032102830.018
regulation of potassium ion transmembrane transportGO:1901379200.018
regulation of multi organism processGO:00439001570.018
regulation of proteolysis involved in cellular protein catabolic processGO:1903050910.018
myeloid leukocyte activationGO:0002274340.018
regulation of anatomical structure morphogenesisGO:00226032860.018
signal transduction by phosphorylationGO:00230142970.017
regulation of peptidase activityGO:00525471800.017
response to extracellular stimulusGO:0009991850.017
negative regulation of developmental processGO:00510932470.017
regulation of cell growthGO:00015581350.017
compound eye developmentGO:004874910.017
lipid storageGO:0019915280.017
Worm
response to disaccharideGO:003428510.017
negative regulation of neurological system processGO:003164520.017
cellular ion homeostasisGO:00068731680.017
positive regulation of cell deathGO:00109422630.017
regulation of homeostatic processGO:00328441210.017
fatty acid metabolic processGO:00066311150.017
cell morphogenesisGO:00009022960.016
reproductive system developmentGO:0061458560.016
guanosine containing compound metabolic processGO:19010682440.016
golgi inheritanceGO:004831320.016
positive regulation of atp catabolic processGO:1903291190.016
metal ion homeostasisGO:00550651690.016
hindbrain developmentGO:003090230.016
Mouse
cell type specific apoptotic processGO:00972851250.016
cellular cation homeostasisGO:00300031630.016
neuron developmentGO:00486661130.016
regulation of response to osmotic stressGO:004748430.016
regulation of cell shapeGO:0008360480.016
mapk cascadeGO:00001652880.015
synaptic vesicle endocytosisGO:004848820.015
negative regulation of protein kinase activityGO:0006469980.015
single organism reproductive processGO:0044702980.015
positive regulation of cysteine type endopeptidase activityGO:2001056790.015
cellular response to metal ionGO:0071248430.015
negative regulation of growthGO:0045926970.015
negative regulation of response to woundingGO:1903035470.015
protein maturationGO:00516042330.015
regulation of lymphocyte activationGO:00512491030.014
leukocyte proliferationGO:0070661740.014
positive regulation of cellular component organizationGO:00511303760.014
cotranslational protein targeting to membraneGO:000661320.014
Yeast
negative regulation of defense responseGO:0031348470.014
regulation of cytoplasmic transportGO:19036491490.014
regulation of transferase activityGO:00513383550.014
Mouse
immune response activating cell surface receptor signaling pathwayGO:0002429450.014
response to electrical stimulusGO:005160210.014
response to cytokineGO:00340972320.014
Mouse
spermatid developmentGO:000728640.014
misfolded protein transportGO:007084310.014
gonad developmentGO:0008406340.013
protein localization to endoplasmic reticulumGO:0070972190.013
peptidyl tyrosine modificationGO:00182121700.013
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.013
regulation of protein ubiquitinationGO:0031396950.013
Mouse
endocytosisGO:00068971590.013
spermatogenesisGO:0007283220.013
immune response regulating signaling pathwayGO:0002764970.013
protein homooligomerizationGO:00512601000.013
response to drugGO:0042493810.013
regulation of phosphatase activityGO:0010921810.013
positive regulation of transportGO:00510503360.013
regulation of phosphoprotein phosphatase activityGO:0043666230.013
oocyte developmentGO:004859910.013
regulation of endopeptidase activityGO:00525481700.013
reproductive processGO:00224141060.013
Yeast
sexual reproductionGO:0019953370.013
Yeast
myeloid cell differentiationGO:00300991170.013
defense response to other organismGO:00985421290.013
regulation of protein localizationGO:00328802960.013
cation homeostasisGO:00550801890.013
heat acclimationGO:001028630.013
regulation of leukocyte apoptotic processGO:2000106250.012
positive regulation of cell activationGO:0050867810.012
primary neural tube formationGO:001402030.012
regulation of endocytosisGO:0030100720.012
epithelium developmentGO:00604292270.012
protein localization to mitochondrionGO:0070585250.012
negative regulation of transferase activityGO:00513481240.012
negative regulation of translationGO:0017148370.012
cellular response to hypoxiaGO:0071456510.012
neural tube formationGO:000184130.012
protein glycosylationGO:0006486620.012
epidermal cell differentiationGO:0009913450.012
peptidyl asparagine modificationGO:0018196110.012
cell divisionGO:00513011680.012
protein import into nucleus translocationGO:0000060220.012
response to steroid hormoneGO:0048545800.012
positive regulation of gliogenesisGO:001401540.012
i kappab kinase nf kappab signalingGO:00072491660.012
interleukin 6 productionGO:0032635370.012
response to atpGO:0033198100.011
tissue homeostasisGO:0001894630.011
positive regulation of meiotic cell cycleGO:005144620.011
vasoconstrictionGO:0042310110.011
response to biotic stimulusGO:00096072760.011
Zebrafish Mouse
response to metal ionGO:0010038840.011
negative regulation of homotypic cell cell adhesionGO:003411130.011
positive regulation of protein kinase activityGO:00458601900.011
Mouse
heart developmentGO:0007507950.011
chondrocyte developmentGO:000206310.011
nuclear exportGO:0051168690.011
regulation of immune effector processGO:0002697910.011
reactive nitrogen species metabolic processGO:200105730.011
regulation of cell developmentGO:00602841610.011
regulation of proteasomal protein catabolic processGO:0061136870.011
negative regulation of cell proliferationGO:00082852280.011
regulation of i kappab kinase nf kappab signalingGO:00431221620.011
cellular chemical homeostasisGO:00550821800.011
second messenger mediated signalingGO:0019932780.011
inflammatory cell apoptotic processGO:000692530.011
positive regulation of atpase activityGO:0032781190.010
gland developmentGO:0048732480.010
regulation of system processGO:00440571010.010
intracellular steroid hormone receptor signaling pathwayGO:0030518610.010
regulation of potassium ion transportGO:0043266240.010
regulation of cysteine type endopeptidase activityGO:20001161270.010
melanin metabolic processGO:000658210.010
positive regulation of defense responseGO:0031349870.010
gamete generationGO:0007276250.010
lipid metabolic processGO:00066293810.010
negative regulation of neural precursor cell proliferationGO:200017810.010
multi organism reproductive processGO:0044703540.010
Yeast
interleukin 2 productionGO:0032623200.010
regulation of cellular amine metabolic processGO:0033238110.010

HSPA5 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
central nervous system diseaseDOID:3311860.412
nervous system diseaseDOID:8634310.412
bone diseaseDOID:0080001880.181
bone development diseaseDOID:0080006550.181
osteogenesis imperfectaDOID:12347130.181
osteochondrodysplasiaDOID:2256350.181
musculoskeletal system diseaseDOID:172230.181
connective tissue diseaseDOID:651090.181
neurodegenerative diseaseDOID:12891020.017
disease of cellular proliferationDOID:145661740.010