Homo sapiens

58 known processes

HSPA4

heat shock 70kDa protein 4

(Aliases: hsp70RY,MGC131852,RY,APG-2,hsp70,HS24/P52)

HSPA4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
protein refoldingGO:0042026140.999
Yeast
protein ubiquitinationGO:00165673140.995
protein foldingGO:0006457380.990
Yeast
post embryonic developmentGO:000979120.937
Worm
protein modification by small protein conjugationGO:00324463420.914
negative regulation of programmed cell deathGO:00430693210.911
Rat
regulation of cellular component biogenesisGO:00440872810.890
protein catabolic processGO:00301633250.861
ubiquitin dependent protein catabolic processGO:00065112060.835
determination of adult lifespanGO:000834020.818
Worm
establishment of protein localization to organelleGO:00725941720.812
cellular macromolecule catabolic processGO:00442653800.799
negative regulation of cell deathGO:00605483450.788
Rat
modification dependent protein catabolic processGO:00199412090.786
proteolysis involved in cellular protein catabolic processGO:00516032440.775
nucleoside monophosphate metabolic processGO:00091231910.745
Yeast
cytoplasmic transportGO:00164823790.741
de novo posttranslational protein foldingGO:005108420.725
chaperone cofactor dependent protein refoldingGO:007038940.711
multicellular organismal agingGO:001025930.676
Worm
purine ribonucleotide catabolic processGO:00091544040.670
Yeast
intracellular protein transmembrane transportGO:0065002240.669
de novo protein foldingGO:000645820.661
modification dependent macromolecule catabolic processGO:00436322120.648
regulation of protein modification by small protein conjugation or removalGO:19033201070.647
nucleoside catabolic processGO:00091644080.634
Yeast
nucleoside phosphate catabolic processGO:19012924120.619
Yeast
purine nucleoside monophosphate catabolic processGO:00091281580.609
Yeast
ribonucleoside monophosphate catabolic processGO:00091581580.591
Yeast
purine ribonucleoside monophosphate metabolic processGO:00091671860.581
Yeast
negative regulation of cellular protein metabolic processGO:00322693530.574
Rat
translationGO:00064121320.566
receptor mediated endocytosisGO:0006898840.564
Worm
cellular macromolecular complex assemblyGO:00346223240.561
protein processingGO:00164852260.556
cellular protein catabolic processGO:00442572610.547
negative regulation of apoptotic processGO:00430663160.520
Rat
positive regulation of apoptotic processGO:00430652460.508
purine ribonucleoside metabolic processGO:00461284370.508
Yeast
regulation of proteasomal protein catabolic processGO:0061136870.508
negative regulation of protein metabolic processGO:00512483910.504
Rat
ribonucleotide catabolic processGO:00092614050.500
Yeast
purine ribonucleoside monophosphate catabolic processGO:00091691580.497
Yeast
chromatin modificationGO:00165682980.470
agingGO:0007568660.464
Worm
immune responseGO:00069553070.460
protein targetingGO:00066051870.453
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.445
purine nucleoside triphosphate metabolic processGO:00091444120.406
Yeast
nuclear transportGO:00511691790.395
nucleocytoplasmic transportGO:00069131760.378
ribonucleoside triphosphate metabolic processGO:00091994120.371
Yeast
posttranscriptional regulation of gene expressionGO:00106082130.364
regulation of protein ubiquitinationGO:0031396950.364
intracellular protein transportGO:00068862700.359
nucleoside triphosphate catabolic processGO:00091433940.347
Yeast
chaperone mediated protein folding requiring cofactorGO:005108510.338
regulation of protein transportGO:00512232130.322
purine nucleotide catabolic processGO:00061954050.302
Yeast
defense responseGO:00069523150.300
nucleotide catabolic processGO:00091664080.300
Yeast
purine ribonucleoside triphosphate catabolic processGO:00092073910.280
Yeast
single organism reproductive processGO:0044702980.280
Worm
purine containing compound catabolic processGO:00725234110.263
Yeast
cellular protein complex assemblyGO:00436231880.259
regulation of bindingGO:00510981110.257
Rat
negative regulation of phosphate metabolic processGO:00459362670.254
Rat
atp metabolic processGO:00460341760.249
Yeast
protein localization to organelleGO:00333652800.248
cell type specific apoptotic processGO:00972851250.247
response to radiationGO:00093141510.242
protein oligomerizationGO:00512591730.237
positive regulation of dna metabolic processGO:0051054730.235
covalent chromatin modificationGO:00165692540.233
proteasomal protein catabolic processGO:00104981760.229
purine nucleoside catabolic processGO:00061523980.218
Yeast
positive regulation of cellular catabolic processGO:00313312840.216
actin filament based processGO:00300292240.213
purine nucleoside triphosphate catabolic processGO:00091463920.210
Yeast
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.209
regulation of protein kinase activityGO:00458592890.205
glycosyl compound catabolic processGO:19016584130.196
Yeast
protein targeting to nucleusGO:00447441040.193
positive regulation of cell deathGO:00109422630.183
negative regulation of intracellular signal transductionGO:19025321830.180
purine ribonucleoside catabolic processGO:00461303980.179
Yeast
organelle assemblyGO:00709251760.170
single organism cellular localizationGO:19025803320.163
purine nucleoside monophosphate metabolic processGO:00091261860.162
Yeast
regulation of gene expression epigeneticGO:0040029730.161
regulation of peptidase activityGO:00525471800.156
negative regulation of protein processingGO:00109551420.154
negative regulation of proteolysisGO:00458611320.153
positive regulation of proteolysisGO:00458621420.153
endocytosisGO:00068971590.151
Worm
regulation of proteolysisGO:00301622930.150
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434710.146
response to abiotic stimulusGO:00096283360.146
Rat
positive regulation of hydrolase activityGO:00513453310.145
vesicle mediated transportGO:00161923710.143
Worm
negative regulation of protein modification processGO:00314002000.136
Rat
cellular response to dna damage stimulusGO:00069743790.136
nucleoside monophosphate catabolic processGO:00091251590.135
Yeast
regulation of intracellular transportGO:00323861950.131
regulation of dna metabolic processGO:00510521530.130
regulation of transferase activityGO:00513383550.126
ribonucleoside catabolic processGO:00424544060.124
Yeast
negative regulation of cellular component organizationGO:00511292350.121
reproductionGO:0000003630.113
Worm
cell developmentGO:00484683280.113
protein maturationGO:00516042330.108
regulation of nucleocytoplasmic transportGO:0046822980.107
protein importGO:00170381300.106
regulation of kinase activityGO:00435493140.102
sex differentiationGO:0007548450.102
Worm
regulation of cytoplasmic transportGO:19036491490.102
positive regulation of programmed cell deathGO:00430682490.102
regenerationGO:003109940.101
embryo developmentGO:00097901230.101
Worm
regulation of establishment of protein localizationGO:00702012420.100
ribonucleoside triphosphate catabolic processGO:00092033910.095
Yeast
regulation of apoptotic signaling pathwayGO:20012331750.093
regulation of protein maturationGO:19033171500.093
embryo development ending in birth or egg hatchingGO:0009792340.091
Worm
protein deubiquitinationGO:0016579790.089
single organism nuclear importGO:19025931040.089
purine ribonucleoside triphosphate metabolic processGO:00092054110.089
Yeast
single organism membrane organizationGO:00448022680.088
regulation of cellular response to stressGO:00801352440.086
reproductive structure developmentGO:0048608550.086
Worm
negative regulation of catalytic activityGO:00430863350.086
regulation of protein localizationGO:00328802960.086
positive regulation of protein catabolic processGO:0045732750.085
positive regulation of catabolic processGO:00098963100.085
regulation of endopeptidase activityGO:00525481700.085
negative regulation of protein ubiquitinationGO:0031397350.084
apoptotic signaling pathwayGO:00971902680.084
histone modificationGO:00165702510.081
rna interferenceGO:001624640.080
atp catabolic processGO:00062001570.080
Yeast
positive regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032436300.079
regulation of protein import into nucleusGO:0042306780.078
mitochondrial transportGO:0006839600.078
immune system developmentGO:00025201950.078
negative regulation of hydrolase activityGO:00513461820.076
regulation of proteolysis involved in cellular protein catabolic processGO:1903050910.074
chromatin organizationGO:00063253510.074
regulation of protein complex assemblyGO:00432541470.073
regulation of viral processGO:00507921030.072
negative regulation of phosphorus metabolic processGO:00105632670.072
Rat
positive regulation of transportGO:00510503360.069
regulation of mitotic spindle checkpointGO:190350480.068
cellular response to cytokine stimulusGO:00713451810.068
anatomical structure formation involved in morphogenesisGO:00486462840.067
Rat
positive regulation of developmental processGO:00510943140.067
Rat
regulation of cytokine productionGO:00018172320.065
regulation of protein targetingGO:1903533910.065
reproductive system developmentGO:0061458560.064
Worm
positive regulation of cellular component organizationGO:00511303760.062
cellular amino acid metabolic processGO:00065201160.062
female gamete generationGO:000729220.061
protein import into nucleusGO:00066061040.061
cardiovascular system developmentGO:00723582620.061
Rat
chordate embryonic developmentGO:0043009340.060
positive regulation of protein complex assemblyGO:0031334860.060
response to external biotic stimulusGO:00432072610.059
growthGO:00400072020.059
response to oxygen containing compoundGO:19017003690.059
response to nitrogen compoundGO:19016981840.056
trna metabolic processGO:0006399350.056
regulation of protein processingGO:00706131500.056
chaperone mediated protein complex assemblyGO:005113190.054
response to light stimulusGO:0009416870.053
microtubule cytoskeleton organizationGO:00002261760.052
nucleoside triphosphate metabolic processGO:00091414220.051
Yeast
cellular component morphogenesisGO:00329893140.050
cytoplasmic translationGO:000218180.050
spermatid differentiationGO:004851540.049
toxin transportGO:190199840.048
positive regulation of cellular component biogenesisGO:00440891580.047
response to topologically incorrect proteinGO:0035966290.046
Worm
regulation of purine nucleotide metabolic processGO:19005422640.046
protein localization to membraneGO:00726571600.046
multicellular organism reproductionGO:0032504420.046
striated muscle cell apoptotic processGO:001065830.046
positive regulation of protein ubiquitinationGO:0031398530.045
negative regulation of protein phosphorylationGO:00019331400.045
Rat
response to organic cyclic compoundGO:00140702040.044
positive regulation of proteolysis involved in cellular protein catabolic processGO:1903052350.043
regulation of purine nucleotide catabolic processGO:00331212050.043
chaperone mediated protein foldingGO:0061077130.042
organophosphate catabolic processGO:00464344300.041
Yeast
regulation of translationGO:0006417890.041
negative regulation of protein modification by small protein conjugation or removalGO:1903321410.041
negative regulation of peptidase activityGO:0010466910.040
secretionGO:00469032540.040
establishment of protein localization to membraneGO:00901501210.039
nuclear importGO:00511701060.039
mapk cascadeGO:00001652880.037
signal transduction by phosphorylationGO:00230142970.036
intracellular steroid hormone receptor signaling pathwayGO:0030518610.036
amine metabolic processGO:0009308440.035
intracellular protein transmembrane importGO:0044743230.035
regulation of cellular protein catabolic processGO:1903362960.035
regulation of innate immune responseGO:0045088970.035
nucleic acid phosphodiester bond hydrolysisGO:00903051020.034
protein localization to nucleusGO:00345041360.033
negative regulation of protein kinase activityGO:0006469980.033
positive regulation of nucleotide metabolic processGO:00459812300.033
immune effector processGO:00022521590.033
positive regulation of nf kappab transcription factor activityGO:0051092810.033
cellular amine metabolic processGO:0044106410.032
regulation of protein serine threonine kinase activityGO:00719001790.032
regulation of mitotic cell cycleGO:00073461890.031
microtubule based processGO:00070172100.031
regulation of ion transportGO:00432691890.031
tissue regenerationGO:004224630.031
positive regulation of protein transportGO:00512221350.031
negative regulation of bindingGO:0051100570.031
Rat
ribonucleoprotein complex subunit organizationGO:0071826810.031
negative regulation of protein maturationGO:19033181420.030
oogenesisGO:004847720.029
developmental process involved in reproductionGO:0003006660.029
Worm
negative regulation of apoptotic signaling pathwayGO:2001234970.029
spermatid developmentGO:000728640.029
regulation of nucleotide metabolic processGO:00061402690.028
innate immune responseGO:00450871780.027
sexual reproductionGO:0019953370.027
regulation of cell cycleGO:00517263930.027
development of primary sexual characteristicsGO:0045137350.027
Worm
protein localization to mitochondrionGO:0070585250.027
ribonucleoside monophosphate metabolic processGO:00091611870.026
Yeast
meiosis iGO:000712740.026
regulation of intracellular protein transportGO:00331571230.026
rna catabolic processGO:0006401710.026
response to other organismGO:00517072610.026
dephosphorylationGO:00163112090.026
regulation of nucleotide catabolic processGO:00308112050.026
regulation of t cell activationGO:0050863770.025
mitotic cell cycleGO:00002783260.025
dna repairGO:00062811980.025
multicellular organismal reproductive processGO:0048609400.024
negative regulation of growthGO:0045926970.024
multi organism cellular processGO:00447641560.024
negative regulation of phosphorylationGO:00423261740.024
Rat
reactive oxygen species metabolic processGO:0072593750.024
small gtpase mediated signal transductionGO:0007264780.023
regulation of cell growthGO:00015581350.023
positive regulation of peptidase activityGO:0010952880.023
actin cytoskeleton organizationGO:00300362070.023
detection of stimulusGO:0051606850.023
system processGO:00030083490.023
positive regulation of nucleocytoplasmic transportGO:0046824540.022
protein dna complex subunit organizationGO:0071824800.022
negative regulation of organelle organizationGO:00106391260.022
response to organonitrogen compoundGO:00102431560.022
cellular response to uvGO:0034644320.022
extrinsic apoptotic signaling pathwayGO:00971911190.021
regulation of mapk cascadeGO:00434082620.021
positive regulation of purine nucleotide metabolic processGO:19005442270.021
positive regulation of apoptotic signaling pathwayGO:2001235700.021
spindle assemblyGO:0051225290.020
mitochondrion organizationGO:00070051560.020
ncrna processingGO:0034470830.020
secretion by cellGO:00329402260.020
regulation of growthGO:00400081650.020
fertilizationGO:0009566120.020
symbiosis encompassing mutualism through parasitismGO:00444031560.020
regulation of cellular amino acid metabolic processGO:000652160.019
cellular response to oxidative stressGO:0034599850.019
actin filament organizationGO:00070151280.019
negative regulation of kinase activityGO:00336731060.019
rna processingGO:00063962550.019
small nucleolar ribonucleoprotein complex assemblyGO:000049130.019
organelle localizationGO:0051640840.019
gonad developmentGO:0008406340.018
Worm
reproductive processGO:00224141060.018
Worm
regulation of viral genome replicationGO:0045069480.018
regulation of protein localization to nucleusGO:1900180850.018
mitochondrial membrane organizationGO:0007006400.018
regulation of immune responseGO:00507762010.018
anterior posterior axis specification embryoGO:000859520.018
gamete generationGO:0007276250.017
regulation of protein bindingGO:0043393660.017
Rat
response to unfolded proteinGO:0006986240.017
regulation of cell differentiationGO:00455953930.017
gene silencingGO:0016458490.017
oocyte differentiationGO:000999420.017
regulation of protein catabolic processGO:00421761550.016
response to peptideGO:1901652650.016
positive regulation of cell cycleGO:00457871400.016
response to cytokineGO:00340972320.016
regulation of multi organism processGO:00439001570.015
positive regulation of mrna metabolic processGO:1903313190.015
response to woundingGO:00096111680.015
posttranscriptional gene silencingGO:0016441250.015
regulation of defense responseGO:00313471540.015
positive regulation of organelle organizationGO:00106381950.014
establishment of protein localization to mitochondrial membraneGO:009015170.014
divalent inorganic cation transportGO:00725111580.014
negative regulation of cell growthGO:0030308830.014
locomotory behaviorGO:000762610.014
cell cycle phase transitionGO:00447701730.014
calcium ion transportGO:00068161470.014
macromolecular complex disassemblyGO:0032984600.014
response to bacteriumGO:00096171440.013
guanosine containing compound catabolic processGO:19010692390.013
positive regulation of nucleotide catabolic processGO:00308131850.013
myosin filament organizationGO:003103320.013
regulation of small gtpase mediated signal transductionGO:00510561560.013
gtp metabolic processGO:00460392390.013
negative regulation of protein serine threonine kinase activityGO:0071901570.013
myeloid cell differentiationGO:00300991170.013
intrinsic apoptotic signaling pathwayGO:00971931270.013
positive regulation of cytokine productionGO:00018191670.013
regulation of cysteine type endopeptidase activityGO:20001161270.013
regulation of atp metabolic processGO:1903578290.012
negative regulation of transferase activityGO:00513481240.012
cell growthGO:00160491600.012
positive regulation of atp catabolic processGO:1903291190.012
nervous system developmentGO:00073992930.012
segmentationGO:003528240.012
neurological system processGO:00508771630.012
cell divisionGO:00513011680.012
cellular component disassemblyGO:0022411920.012
negative regulation of neuron apoptotic processGO:0043524230.012
response to lipidGO:00339932060.012
negative regulation of protein transportGO:0051224750.011
oocyte developmentGO:004859910.011
regulation of cytoskeleton organizationGO:00514931770.011
intracellular receptor signaling pathwayGO:00305221040.011
sperm motilityGO:003031760.011
mrna catabolic processGO:0006402560.011
spermatogenesisGO:0007283220.011
positive regulation of protein modification by small protein conjugation or removalGO:1903322610.011
negative regulation of neuron deathGO:1901215320.011
cell agingGO:0007569520.011
macromolecule methylationGO:0043414970.011
cell morphogenesisGO:00009022960.010
positive regulation of kinase activityGO:00336742040.010
cell cell signalingGO:00072671550.010
cellular response to organonitrogen compoundGO:00714171240.010
regulation of dna replicationGO:0006275680.010
muscle structure developmentGO:0061061980.010

HSPA4 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:8634310.016
central nervous system diseaseDOID:3311860.016