Homo sapiens

24 known processes

PCSK2

proprotein convertase subtilisin/kexin type 2

(Aliases: PC2,NEC 2,NEC-2,NEC2,SPC2)

PCSK2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cell cell signalingGO:00072671550.255
ion transmembrane transportGO:00342203380.203
transmembrane transportGO:00550853990.200
system processGO:00030083490.196
Human
cation transmembrane transportGO:00986552380.186
inorganic cation transmembrane transportGO:00986621940.168
inorganic ion transmembrane transportGO:00986602310.141
nervous system developmentGO:00073992930.129
cellular ketone metabolic processGO:0042180800.114
secretionGO:00469032540.100
Human
locomotory behaviorGO:000762610.099
Fly
cation transportGO:00068123310.097
secretion by cellGO:00329402260.095
Human
response to oxygen containing compoundGO:19017003690.094
cellular response to endogenous stimulusGO:00714953360.091
regulation of cellular amino acid metabolic processGO:000652160.087
regulation of secretion by cellGO:19035301770.087
positive regulation of transportGO:00510503360.084
neurotransmitter secretionGO:000726940.084
regulation of cellular ketone metabolic processGO:0010565500.083
cell developmentGO:00484683280.083
regulation of cellular amine metabolic processGO:0033238110.078
metal ion transportGO:00300012720.078
post embryonic developmentGO:000979120.077
Fly
neurogenesisGO:00220081690.076
positive regulation of synaptic transmissionGO:005080640.075
cellular amine metabolic processGO:0044106410.071
neuron differentiationGO:00301821380.071
chemical homeostasisGO:00488783060.069
Fly
regulation of membrane potentialGO:0042391950.067
cellular amino acid metabolic processGO:00065201160.067
regulation of ion transportGO:00432691890.066
actin filament based processGO:00300292240.065
regulation of synaptic plasticityGO:004816730.065
organophosphate catabolic processGO:00464344300.064
regulation of secretionGO:00510461940.063
ion homeostasisGO:00508012300.063
generation of neuronsGO:00486991520.062
amine metabolic processGO:0009308440.061
neurological system processGO:00508771630.061
purine ribonucleoside catabolic processGO:00461303980.060
cell projection organizationGO:00300302520.060
small gtpase mediated signal transductionGO:0007264780.060
synaptic transmissionGO:0007268610.060
regulation of neurotransmitter secretionGO:004692830.059
ras protein signal transductionGO:0007265730.058
lipid metabolic processGO:00066293810.058
positive regulation of cellular amine metabolic processGO:003324070.057
cell adhesionGO:00071553250.056
negative regulation of multicellular organismal processGO:00512413170.055
Human
regulation of locomotionGO:00400123290.055
action potentialGO:0001508340.055
neuron fate commitmentGO:004866320.054
positive regulation of cellular amino acid metabolic processGO:004576430.053
sodium ion transportGO:0006814610.053
regulation of hormone levelsGO:00108171250.053
positive regulation of cellular component organizationGO:00511303760.053
ribonucleoside triphosphate metabolic processGO:00091994120.053
vesicle mediated transportGO:00161923710.052
regulation of cellular component movementGO:00512703340.052
cellular response to oxygen containing compoundGO:19017012760.051
signal releaseGO:0023061700.051
regulation of purine nucleotide metabolic processGO:19005422640.051
purine ribonucleotide catabolic processGO:00091544040.050
regulation of cell differentiationGO:00455953930.049
positive regulation of developmental processGO:00510943140.049
spinal cord developmentGO:002151040.049
regulation of transmembrane transportGO:00347621390.047
response to organonitrogen compoundGO:00102431560.047
negative regulation of transportGO:00510511760.047
positive regulation of hydrolase activityGO:00513453310.046
purine nucleoside catabolic processGO:00061523980.046
nucleoside catabolic processGO:00091644080.046
hindbrain developmentGO:003090230.046
nucleoside triphosphate metabolic processGO:00091414220.046
single organism cellular localizationGO:19025803320.046
negative regulation of cellular component organizationGO:00511292350.045
single organism membrane organizationGO:00448022680.045
negative regulation of phosphate metabolic processGO:00459362670.045
regulation of protein localizationGO:00328802960.045
purine ribonucleoside metabolic processGO:00461284370.045
membrane organizationGO:00610242920.045
ribonucleoside triphosphate catabolic processGO:00092033910.045
cardiac muscle cell contractionGO:008600340.044
cellular potassium ion transportGO:0071804600.044
adenylate cyclase modulating g protein coupled receptor signaling pathwayGO:0007188430.044
cytoplasmic transportGO:00164823790.043
hormone secretionGO:0046879650.043
regulation of ion transmembrane transportGO:00347651320.042
ribonucleotide catabolic processGO:00092614050.042
monovalent inorganic cation transportGO:00156721280.042
biological adhesionGO:00226103310.042
positive regulation of secretionGO:00510471160.041
purine ribonucleoside triphosphate catabolic processGO:00092073910.041
purine nucleotide catabolic processGO:00061954050.041
cellular lipid metabolic processGO:00442553030.041
regulation of kinase activityGO:00435493140.041
nucleotide catabolic processGO:00091664080.041
regulation of nucleotide metabolic processGO:00061402690.041
nucleoside phosphate catabolic processGO:19012924120.040
ribonucleoside catabolic processGO:00424544060.040
neuron projection developmentGO:00311751060.040
peripheral nervous system developmentGO:000742220.040
nucleoside triphosphate catabolic processGO:00091433940.040
regulation of cellular component biogenesisGO:00440872810.039
nitrogen compound transportGO:00717051910.039
response to abiotic stimulusGO:00096283360.039
positive regulation of cellular catabolic processGO:00313312840.039
glycosyl compound catabolic processGO:19016584130.039
positive regulation of phosphorylationGO:00423273940.038
gtp catabolic processGO:00061842370.038
oogenesisGO:004847720.038
gtp metabolic processGO:00460392390.038
negative regulation of phosphorus metabolic processGO:00105632670.038
g protein coupled receptor signaling pathwayGO:00071862070.038
regulation of cell motilityGO:20001452990.038
female gamete generationGO:000729220.038
guanosine containing compound metabolic processGO:19010682440.038
motor neuron axon guidanceGO:000804520.038
regulation of cell developmentGO:00602841610.037
positive regulation of catabolic processGO:00098963100.037
neuron developmentGO:00486661130.037
purine nucleoside triphosphate metabolic processGO:00091444120.037
neuromuscular junction developmentGO:000752830.037
cellular response to nitrogen compoundGO:19016991440.037
positive regulation of acrosome reactionGO:200034440.037
central nervous system developmentGO:00074171230.036
blood circulationGO:00080151130.036
Human
positive regulation of cell proliferationGO:00082843010.036
negative regulation of catalytic activityGO:00430863350.036
Human
purine containing compound catabolic processGO:00725234110.036
multicellular organismal agingGO:001025930.036
pancreatic a cell differentiationGO:000331010.036
positive regulation of nucleotide metabolic processGO:00459812300.036
purine nucleoside triphosphate catabolic processGO:00091463920.036
response to hormoneGO:00097251750.036
negative regulation of protein metabolic processGO:00512483910.036
Human
positive regulation of protein phosphorylationGO:00019343130.036
purine ribonucleoside triphosphate metabolic processGO:00092054110.035
regulation of cell cycleGO:00517263930.035
regenerationGO:003109940.035
adult locomotory behaviorGO:000834410.035
peptide transportGO:0015833740.035
negative regulation of cell deathGO:00605483450.034
protein localization to organelleGO:00333652800.034
cell morphogenesisGO:00009022960.034
response to organic cyclic compoundGO:00140702040.034
enzyme linked receptor protein signaling pathwayGO:00071673030.034
determination of adult lifespanGO:000834020.034
negative regulation of cellular protein metabolic processGO:00322693530.033
Human
second messenger mediated signalingGO:0019932780.033
nucleoside phosphate biosynthetic processGO:19012931090.033
sodium ion transmembrane transportGO:0035725590.033
regulation of acrosome reactionGO:006004640.033
regulation of system processGO:00440571010.033
anion transportGO:00068201610.033
positive regulation of secretion by cellGO:19035321080.032
cellular response to organonitrogen compoundGO:00714171240.032
segmentationGO:003528240.032
positive regulation of cell differentiationGO:00455972110.032
startle responseGO:000196430.032
carbohydrate derivative biosynthetic processGO:19011372070.032
negative regulation of synaptic transmissionGO:005080520.032
limbic system developmentGO:002176130.032
nerve developmentGO:002167540.032
positive regulation of nucleotide catabolic processGO:00308131850.032
nucleotide biosynthetic processGO:00091651090.032
guanosine containing compound catabolic processGO:19010692390.032
actin cytoskeleton organizationGO:00300362070.032
positive regulation of ras gtpase activityGO:00323201170.031
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messengerGO:0007187430.031
single organism cell adhesionGO:00986021790.031
cellular component morphogenesisGO:00329893140.031
regulation of transporter activityGO:0032409820.031
intracellular protein transportGO:00068862700.031
regulation of transferase activityGO:00513383550.031
metencephalon developmentGO:002203720.031
regulation of nucleotide catabolic processGO:00308112050.031
dephosphorylationGO:00163112090.031
positive regulation of cell developmentGO:0010720920.031
regulation of protein transportGO:00512232130.031
memoryGO:000761330.030
mapk cascadeGO:00001652880.030
response to lipidGO:00339932060.030
brain developmentGO:0007420970.030
regulation of cell migrationGO:00303342890.030
cell morphogenesis involved in differentiationGO:00009041440.030
regulation of protein kinase activityGO:00458592890.029
response to nitrogen compoundGO:19016981840.029
hormone transportGO:0009914680.029
circulatory system processGO:00030131130.029
Human
cell differentiation in spinal cordGO:002151510.029
sensory perceptionGO:00076001030.029
positive regulation of purine nucleotide metabolic processGO:19005442270.029
organonitrogen compound biosynthetic processGO:19015662000.028
Human
multicellular organismal response to stressGO:003355510.028
forebrain generation of neuronsGO:002187230.028
muscle contractionGO:0006936730.028
divalent inorganic cation homeostasisGO:00725071360.028
matingGO:000761810.028
peptide secretionGO:0002790510.028
regulation of metal ion transportGO:00109591200.028
positive regulation of nucleoside metabolic processGO:00459791860.028
endomembrane system organizationGO:00102561960.028
cellular chemical homeostasisGO:00550821800.028
regulation of anatomical structure morphogenesisGO:00226032860.028
regulation of establishment of protein localizationGO:00702012420.027
divalent metal ion transportGO:00708381520.027
cardiovascular system developmentGO:00723582620.027
regulation of ras gtpase activityGO:00323181280.027
regulation of nucleoside metabolic processGO:00091182090.027
camp metabolic processGO:0046058610.027
positive regulation of purine nucleotide catabolic processGO:00331231850.027
positive regulation of apoptotic processGO:00430652460.027
cellular response to organic cyclic compoundGO:00714071270.027
negative regulation of cell proliferationGO:00082852280.027
regulation of cell cycle processGO:00105642660.027
neuron projection regenerationGO:003110210.027
blastoderm segmentationGO:000735020.027
amide transportGO:0042886760.027
regulation of purine nucleotide catabolic processGO:00331212050.027
positive regulation of epithelial cell proliferation involved in wound healingGO:006005430.026
regulation of mapk cascadeGO:00434082620.026
signal transduction by phosphorylationGO:00230142970.026
associative learningGO:000830610.026
cellular response to hormone stimulusGO:00328701250.026
regulation of vesicle mediated transportGO:00606271300.026
positive regulation of gtpase activityGO:00435471660.026
positive regulation of ion transportGO:0043270870.026
regulation of growthGO:00400081650.026
negative regulation of cellular amine metabolic processGO:003323930.025
cyclic nucleotide metabolic processGO:0009187820.025
rho protein signal transductionGO:0007266260.025
divalent inorganic cation transportGO:00725111580.025
regulation of atrial cardiac muscle cell membrane repolarizationGO:006037240.025
cardiac muscle contractionGO:0060048340.025
regulation of gtp catabolic processGO:00331241800.025
ribonucleotide biosynthetic processGO:0009260810.025
regulation of lipid metabolic processGO:0019216960.025
cyclic purine nucleotide metabolic processGO:0052652600.025
regulation of ras protein signal transductionGO:00465781550.024
muscle system processGO:0003012810.024
establishment of protein localization to organelleGO:00725941720.024
negative regulation of apoptotic processGO:00430663160.024
exocytosisGO:0006887710.024
cranial nerve developmentGO:002154540.024
peptide hormone secretionGO:0030072500.024
regulation of cytokine productionGO:00018172320.024
Human
positive regulation of protein kinase activityGO:00458601900.024
organophosphate biosynthetic processGO:00904071630.024
potassium ion transmembrane transportGO:0071805600.024
cardiac right ventricle morphogenesisGO:000321530.024
regulation of gtpase activityGO:00430871800.024
positive regulation of gtp catabolic processGO:00331261660.023
cell fate determinationGO:000170930.023
regulation of small gtpase mediated signal transductionGO:00510561560.023
potassium ion transportGO:0006813620.023
negative regulation of cellular amino acid metabolic processGO:004576320.023
mitotic cell cycleGO:00002783260.023
regulation of excitatory postsynaptic membrane potentialGO:006007910.023
negative regulation of cell differentiationGO:00455961710.023
purine nucleotide biosynthetic processGO:0006164840.023
positive regulation of cell deathGO:00109422630.023
detection of stimulusGO:0051606850.023
regulation of nervous system developmentGO:0051960880.023
lipid biosynthetic processGO:00086101770.023
calcium ion transportGO:00068161470.023
negative regulation of protein modification processGO:00314002000.022
metal ion homeostasisGO:00550651690.022
regulation of cellular response to stressGO:00801352440.022
epithelium developmentGO:00604292270.022
neuroblast proliferationGO:000740540.022
regulation of intracellular transportGO:00323861950.022
carbohydrate metabolic processGO:00059752070.022
multicellular organismal signalingGO:0035637340.022
rhythmic behaviorGO:000762220.022
positive regulation of kinase activityGO:00336742040.022
cellular ion homeostasisGO:00068731680.022
regulation of neurogenesisGO:0050767820.022
actin mediated cell contractionGO:0070252120.022
canonical wnt signaling pathway involved in osteoblast differentiationGO:004433920.022
negative regulation of programmed cell deathGO:00430693210.022
mitotic cell cycle processGO:19030472860.022
regulation of neuronal synaptic plasticityGO:004816810.022
cation homeostasisGO:00550801890.022
forebrain neuron differentiationGO:002187930.022
cellular macromolecular complex assemblyGO:00346223240.022
canonical wnt signaling pathway involved in mesenchymal stem cell differentiationGO:004433820.022
negative regulation of developmental processGO:00510932470.022
regulation of cyclic nucleotide biosynthetic processGO:0030802490.022
wnt signaling pathwayGO:00160551560.022
cerebellum developmentGO:002154920.022
regulation of cell projection organizationGO:00313441070.022
regulation of transmission of nerve impulseGO:005196920.022
positive regulation of transferase activityGO:00513472270.021
regulation of wnt signaling pathwayGO:00301111230.021
anatomical structure formation involved in morphogenesisGO:00486462840.021
regulation of transmembrane transporter activityGO:0022898740.021
cellular response to dna damage stimulusGO:00069743790.021
behaviorGO:00076101120.021
Fly
growthGO:00400072020.021
actin filament based movementGO:0030048170.021
protein targetingGO:00066051870.021
positive regulation of programmed cell deathGO:00430682490.021
head developmentGO:00603221080.021
negative regulation of phosphorylationGO:00423261740.021
regulation of hormone secretionGO:0046883570.021
purine containing compound biosynthetic processGO:0072522880.020
nucleocytoplasmic transportGO:00069131760.020
adenylate cyclase inhibiting g protein coupled glutamate receptor signaling pathwayGO:000719640.020
regulation of sequence specific dna binding transcription factor activityGO:00510902110.020
regulation of proteolysisGO:00301622930.020
Human
cell part morphogenesisGO:00329901370.020
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.020
ventral spinal cord developmentGO:002151710.020
circadian behaviorGO:004851220.020
regulation of actin filament based processGO:00329701410.020
sensory perception of painGO:001923340.020
reactive nitrogen species metabolic processGO:200105730.020
organ formationGO:004864530.020
positive regulation of organelle organizationGO:00106381950.020
regulation of neuron differentiationGO:0045664700.020
epithelial cell differentiationGO:00308551410.020
anterior posterior axis specification embryoGO:000859520.020
response to growth factorGO:00708482050.020
response to axon injuryGO:004867810.020
cell projection morphogenesisGO:00488581290.020
purine ribonucleotide biosynthetic processGO:0009152790.020
cellular homeostasisGO:00197251960.020
nuclear transportGO:00511691790.020
positive regulation of mapk cascadeGO:00434101900.019
morphogenesis of embryonic epitheliumGO:001633140.019
canonical wnt signaling pathwayGO:00600701160.019
regulation of camp metabolic processGO:0030814520.019
immune responseGO:00069553070.019
glial cell migrationGO:000834740.019
response to woundingGO:00096111680.019
cell fate commitment involved in pattern specificationGO:006058110.019
calcium ion transmembrane transportGO:0070588760.019
adenylate cyclase inhibiting serotonin receptor signaling pathwayGO:000719820.019
axon regenerationGO:003110310.019
cellular response to growth factor stimulusGO:00713631970.019
small molecule biosynthetic processGO:00442831570.019
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.019
negative regulation of hydrolase activityGO:00513461820.019
Human
ribose phosphate biosynthetic processGO:0046390820.019
regulation of protein serine threonine kinase activityGO:00719001790.019
regulation of cytoskeleton organizationGO:00514931770.019
cell growthGO:00160491600.019
regulation of cell morphogenesisGO:00226041530.019
protein catabolic processGO:00301633250.019
Human
long term synaptic potentiationGO:006029110.019
oxidation reduction processGO:00551143960.019
regulation of cell growthGO:00015581350.019
oocyte differentiationGO:000999420.019
anterior posterior axis specificationGO:000994820.018
protein localization to membraneGO:00726571600.018
positive regulation of gliogenesisGO:001401540.018
cytokine productionGO:00018162470.018
Human
sex determinationGO:000753030.018
pituitary gland developmentGO:002198320.018
negative regulation of intracellular signal transductionGO:19025321830.018
oocyte developmentGO:004859910.018
cellular macromolecule catabolic processGO:00442653800.018
Human
protein maturationGO:00516042330.018
cell divisionGO:00513011680.018
camp biosynthetic processGO:0006171470.018
negative regulation of protein phosphorylationGO:00019331400.018
single organism carbohydrate metabolic processGO:00447231930.018
regulation of peptide transportGO:0090087620.018
positive regulation of cellular component movementGO:00512721810.018
single organismal cell cell adhesionGO:00163371480.018
cell type specific apoptotic processGO:00972851250.018
tripartite regional subdivisionGO:000735120.018
negative regulation of gliogenesisGO:001401430.018
compound eye developmentGO:004874910.018
protein oligomerizationGO:00512591730.018
reactive oxygen species metabolic processGO:0072593750.018
cyclic nucleotide biosynthetic processGO:0009190610.018
regulation of response to external stimulusGO:00321012220.018
negative regulation of secretion by cellGO:1903531520.018
negative regulation of cell cycleGO:00457861930.017
organic anion transportGO:00157111030.017
negative regulation of cytosolic calcium ion concentrationGO:005148110.017
cellular cation homeostasisGO:00300031630.017
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.017
defense responseGO:00069523150.017
negative regulation of secretionGO:0051048580.017
protein modification by small protein conjugationGO:00324463420.017
chromatin organizationGO:00063253510.017
apoptotic signaling pathwayGO:00971902680.017
regulation of protein complex assemblyGO:00432541470.017
spermatid differentiationGO:004851540.017
ossificationGO:00015031210.017
regulation of exocytosisGO:0017157460.017
gamma aminobutyric acid signaling pathwayGO:000721430.017
non canonical wnt signaling pathway via mapk cascadeGO:003803040.017
synaptic vesicle exocytosisGO:001607930.017
protein targeting to nucleusGO:00447441040.017
positive regulation of cell motilityGO:20001471770.017
astrocyte differentiationGO:004870840.017
negative regulation of cell migrationGO:00303361020.017
hippocampus developmentGO:002176610.017
protein autophosphorylationGO:00467771230.017
chromatin modificationGO:00165682980.017
neural crest cell developmentGO:001403230.016
reactive oxygen species biosynthetic processGO:190340940.016
posttranscriptional regulation of gene expressionGO:00106082130.016
regulation of cell adhesionGO:00301551660.016
glycerolipid metabolic processGO:00464861070.016
forebrain regionalizationGO:002187130.016
regulation of blood circulationGO:1903522590.016
inner ear morphogenesisGO:004247240.016
regulation of mitotic cell cycleGO:00073461890.016
regulation of cyclic nucleotide metabolic processGO:0030799630.016
maintenance of locationGO:00512351120.016
monocarboxylic acid metabolic processGO:00327871850.016
positive regulation of immune system processGO:00026842830.016
regulation of axon guidanceGO:190266730.016
negative regulation of cell developmentGO:0010721480.016
protein localization to nucleusGO:00345041360.016
protein ubiquitinationGO:00165673140.016
regulation of homeostatic processGO:00328441210.016
regulation of cytoplasmic transportGO:19036491490.016
long term memoryGO:000761620.016
regulation of intracellular protein transportGO:00331571230.016
positive regulation of cytokine productionGO:00018191670.016
response to external biotic stimulusGO:00432072610.016
photoreceptor cell differentiationGO:004653020.016
cerebral cortex gabaergic interneuron differentiationGO:002189210.015
negative regulation of transmission of nerve impulseGO:005197010.015
somitogenesisGO:000175620.015
plasma membrane organizationGO:00070091150.015
regulation of ion transmembrane transporter activityGO:0032412720.015
regulation of male gonad developmentGO:200001840.015
regulation of erk1 and erk2 cascadeGO:0070372990.015
regulation of nucleotide biosynthetic processGO:0030808500.015
peptidyl tyrosine modificationGO:00182121700.015
establishment of protein localization to membraneGO:00901501210.015
histone modificationGO:00165702510.015
regulation of neural precursor cell proliferationGO:200017740.015
insulin secretionGO:0030073390.015
regulation of glial cell differentiationGO:004568530.015
positive regulation of cellular component biogenesisGO:00440891580.015
response to biotic stimulusGO:00096072760.015
organic hydroxy compound metabolic processGO:19016151470.015
cellular protein complex assemblyGO:00436231880.015
positive regulation of cell projection organizationGO:0031346640.015
cellular calcium ion homeostasisGO:00068741170.015
epidermal growth factor activated receptor transactivation by g protein coupled receptor signaling pathwayGO:003562540.015
spinal cord dorsal ventral patterningGO:002151320.015
fatty acid metabolic processGO:00066311150.015
protein importGO:00170381300.015
cerebral cortex cell migrationGO:002179530.015
negative regulation of canonical wnt signaling pathwayGO:0090090550.015
striated muscle contractionGO:0006941520.015
protein localization to plasma membraneGO:0072659930.015
transmission of nerve impulseGO:0019226110.015
neuronal action potentialGO:001922890.015
spermatid developmentGO:000728640.015
regulation of dephosphorylationGO:0035303960.015
regulation of reactive oxygen species biosynthetic processGO:190342630.015
regulation of canonical wnt signaling pathwayGO:0060828880.015
organelle assemblyGO:00709251760.015
negative regulation of insulin secretion involved in cellular response to glucose stimulusGO:006117910.015
wound healingGO:00420601150.015
oxidative stress induced premature senescenceGO:009040330.015
rna processingGO:00063962550.015
positive regulation of nervous system developmentGO:0051962540.015
positive regulation of neurogenesisGO:0050769490.015
membrane hyperpolarizationGO:006008110.015
calcium ion homeostasisGO:00550741220.014
proteolysis involved in cellular protein catabolic processGO:00516032440.014
tissue regenerationGO:004224630.014
positive regulation of neuron differentiationGO:0045666400.014
visual learningGO:000854210.014
positive regulation of aldosterone metabolic processGO:003234620.014
positive regulation of purine nucleotide biosynthetic processGO:1900373380.014
microtubule based processGO:00070172100.014
glycerophospholipid metabolic processGO:0006650840.014

PCSK2 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:8634310.047
central nervous system diseaseDOID:3311860.047
disease of metabolismDOID:00146672950.039
sensory system diseaseDOID:00501552030.029
eye and adnexa diseaseDOID:14921500.024
eye diseaseDOID:56141490.023
retinal diseaseDOID:56791180.020
brain diseaseDOID:936730.020
disease of cellular proliferationDOID:145661740.020
cancerDOID:1621670.020
inherited metabolic disorderDOID:6552420.019
organ system cancerDOID:00506861640.016
musculoskeletal system diseaseDOID:172230.014