Homo sapiens

0 known processes

VPREB1

pre-B lymphocyte 1

(Aliases: VPREB,IGVPB,IGI)

VPREB1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of cellular amino acid metabolic processGO:000652160.081
regulation of cellular amine metabolic processGO:0033238110.077
amine metabolic processGO:0009308440.077
cellular amine metabolic processGO:0044106410.074
regulation of cellular ketone metabolic processGO:0010565500.068
defense responseGO:00069523150.067
positive regulation of cellular amine metabolic processGO:003324070.062
post embryonic developmentGO:000979120.059
positive regulation of cellular amino acid metabolic processGO:004576430.058
cellular ketone metabolic processGO:0042180800.057
negative regulation of protein metabolic processGO:00512483910.055
positive regulation of phosphorylationGO:00423273940.053
system processGO:00030083490.051
immune responseGO:00069553070.046
Mouse
regulation of cell differentiationGO:00455953930.045
response to oxygen containing compoundGO:19017003690.043
muscle system processGO:0003012810.042
cytoplasmic transportGO:00164823790.042
nucleoside phosphate catabolic processGO:19012924120.041
negative regulation of cellular protein metabolic processGO:00322693530.041
positive regulation of immune system processGO:00026842830.040
organophosphate catabolic processGO:00464344300.040
cellular amino acid metabolic processGO:00065201160.040
ribonucleoside triphosphate catabolic processGO:00092033910.040
response to external biotic stimulusGO:00432072610.039
regulation of protein kinase activityGO:00458592890.038
purine nucleoside triphosphate metabolic processGO:00091444120.037
ras protein signal transductionGO:0007265730.037
single organism cellular localizationGO:19025803320.036
regulation of cellular component movementGO:00512703340.036
ribonucleoside triphosphate metabolic processGO:00091994120.036
response to bacteriumGO:00096171440.036
female gamete generationGO:000729220.036
cell projection organizationGO:00300302520.035
negative regulation of transportGO:00510511760.035
determination of adult lifespanGO:000834020.035
chemical homeostasisGO:00488783060.035
response to other organismGO:00517072610.035
cellular response to oxygen containing compoundGO:19017012760.035
cellular macromolecule catabolic processGO:00442653800.034
positive regulation of transportGO:00510503360.034
transmembrane transportGO:00550853990.034
ribonucleotide catabolic processGO:00092614050.034
multicellular organismal agingGO:001025930.034
purine ribonucleoside metabolic processGO:00461284370.034
actin filament based processGO:00300292240.034
cytokine productionGO:00018162470.034
regulation of locomotionGO:00400123290.034
purine ribonucleoside triphosphate metabolic processGO:00092054110.034
glycosyl compound catabolic processGO:19016584130.033
nucleoside triphosphate catabolic processGO:00091433940.033
nucleoside triphosphate metabolic processGO:00091414220.033
response to biotic stimulusGO:00096072760.033
regulation of cytokine productionGO:00018172320.032
purine nucleoside triphosphate catabolic processGO:00091463920.032
purine containing compound catabolic processGO:00725234110.032
nucleotide catabolic processGO:00091664080.032
regulation of mapk cascadeGO:00434082620.032
negative regulation of multicellular organismal processGO:00512413170.032
small gtpase mediated signal transductionGO:0007264780.032
positive regulation of catabolic processGO:00098963100.031
purine ribonucleoside catabolic processGO:00461303980.031
positive regulation of cellular component organizationGO:00511303760.031
purine ribonucleotide catabolic processGO:00091544040.031
cellular response to endogenous stimulusGO:00714953360.031
oogenesisGO:004847720.031
nucleoside catabolic processGO:00091644080.031
cell developmentGO:00484683280.031
nervous system developmentGO:00073992930.031
ribonucleoside catabolic processGO:00424544060.030
lipid biosynthetic processGO:00086101770.030
chromatin organizationGO:00063253510.030
cardiac muscle cell contractionGO:008600340.030
lipid metabolic processGO:00066293810.030
hematopoietic or lymphoid organ developmentGO:00485341860.030
Mouse
positive regulation of cell proliferationGO:00082843010.030
regulation of establishment of protein localizationGO:00702012420.030
protein catabolic processGO:00301633250.029
purine ribonucleoside triphosphate catabolic processGO:00092073910.029
negative regulation of programmed cell deathGO:00430693210.029
positive regulation of hydrolase activityGO:00513453310.029
regulation of proteolysisGO:00301622930.029
positive regulation of protein phosphorylationGO:00019343130.029
negative regulation of catalytic activityGO:00430863350.028
intracellular protein transportGO:00068862700.028
cellular component morphogenesisGO:00329893140.028
Mouse
purine nucleoside catabolic processGO:00061523980.028
regulation of cellular response to stressGO:00801352440.028
innate immune responseGO:00450871780.028
purine nucleotide catabolic processGO:00061954050.028
regulation of cell motilityGO:20001452990.028
actin filament based movementGO:0030048170.028
cellular macromolecular complex assemblyGO:00346223240.028
negative regulation of phosphorus metabolic processGO:00105632670.028
response to abiotic stimulusGO:00096283360.027
immune system developmentGO:00025201950.027
Mouse
segmentationGO:003528240.027
positive regulation of cell deathGO:00109422630.027
response to organic cyclic compoundGO:00140702040.027
mapk cascadeGO:00001652880.027
regulation of nucleotide metabolic processGO:00061402690.027
regulation of cell cycleGO:00517263930.026
ion transmembrane transportGO:00342203380.026
associative learningGO:000830610.026
regulation of transferase activityGO:00513383550.026
signal transduction by phosphorylationGO:00230142970.026
cation transportGO:00068123310.026
regulation of cell cycle processGO:00105642660.026
ion homeostasisGO:00508012300.026
proteolysis involved in cellular protein catabolic processGO:00516032440.026
cellular lipid metabolic processGO:00442553030.026
negative regulation of protein modification processGO:00314002000.025
protein maturationGO:00516042330.025
oxidation reduction processGO:00551143960.025
cellular chemical homeostasisGO:00550821800.025
neurological system processGO:00508771630.025
chromatin modificationGO:00165682980.025
hemopoiesisGO:00300971800.025
Mouse
secretionGO:00469032540.025
cell morphogenesisGO:00009022960.025
Mouse
biological adhesionGO:00226103310.024
actin mediated cell contractionGO:0070252120.024
regulation of protein localizationGO:00328802960.024
cell activationGO:00017752130.024
Mouse
regulation of intracellular transportGO:00323861950.024
regulation of system processGO:00440571010.024
locomotory behaviorGO:000762610.024
anatomical structure formation involved in morphogenesisGO:00486462840.024
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.024
cell adhesionGO:00071553250.024
defense response to other organismGO:00985421290.024
regulation of protein transportGO:00512232130.023
cellular cation homeostasisGO:00300031630.023
negative regulation of phosphate metabolic processGO:00459362670.023
cellular response to dna damage stimulusGO:00069743790.023
protein localization to organelleGO:00333652800.023
positive regulation of programmed cell deathGO:00430682490.023
regulation of cellular component biogenesisGO:00440872810.023
response to cytokineGO:00340972320.023
positive regulation of cellular catabolic processGO:00313312840.023
reactive oxygen species metabolic processGO:0072593750.023
negative regulation of cellular amine metabolic processGO:003323930.023
leukocyte activationGO:00453211640.023
Mouse
single organism membrane organizationGO:00448022680.023
positive regulation of apoptotic processGO:00430652460.022
sensory perception of smellGO:000760820.022
positive regulation of immune responseGO:00507781590.022
regulation of immune responseGO:00507762010.022
regulation of cytoplasmic transportGO:19036491490.022
cellular metal ion homeostasisGO:00068751460.022
membrane organizationGO:00610242920.022
cellular response to cytokine stimulusGO:00713451810.022
cellular protein catabolic processGO:00442572610.022
positive regulation of cytokine productionGO:00018191670.022
negative regulation of cellular amino acid metabolic processGO:004576320.022
regulation of sequence specific dna binding transcription factor activityGO:00510902110.021
mitotic cell cycle processGO:19030472860.021
maintenance of locationGO:00512351120.021
cellular homeostasisGO:00197251960.021
striated muscle contractionGO:0006941520.021
enzyme linked receptor protein signaling pathwayGO:00071673030.021
metal ion homeostasisGO:00550651690.021
divalent inorganic cation homeostasisGO:00725071360.021
actin cytoskeleton organizationGO:00300362070.021
cation homeostasisGO:00550801890.021
regulation of purine nucleotide catabolic processGO:00331212050.021
rho protein signal transductionGO:0007266260.021
negative regulation of cell deathGO:00605483450.021
guanosine containing compound catabolic processGO:19010692390.021
negative regulation of developmental processGO:00510932470.020
neuromuscular junction developmentGO:000752830.020
vesicle mediated transportGO:00161923710.020
regulation of secretionGO:00510461940.020
reactive nitrogen species metabolic processGO:200105730.020
cellular divalent inorganic cation homeostasisGO:00725031280.020
regulation of reactive oxygen species biosynthetic processGO:190342630.020
protein processingGO:00164852260.020
mitotic cell cycleGO:00002783260.020
spermatid differentiationGO:004851540.020
metal ion transportGO:00300012720.020
blastoderm segmentationGO:000735020.019
response to nitrogen compoundGO:19016981840.019
regulation of purine nucleotide metabolic processGO:19005422640.019
covalent chromatin modificationGO:00165692540.019
negative regulation of cellular component organizationGO:00511292350.019
positive regulation of cellular component biogenesisGO:00440891580.019
regulation of nucleoside metabolic processGO:00091182090.019
divalent metal ion transportGO:00708381520.019
memoryGO:000761330.019
calcium ion homeostasisGO:00550741220.019
circadian behaviorGO:004851220.019
inorganic cation transmembrane transportGO:00986621940.019
muscle contractionGO:0006936730.019
generation of neuronsGO:00486991520.019
regenerationGO:003109940.019
symbiosis encompassing mutualism through parasitismGO:00444031560.018
spermatid developmentGO:000728640.018
histone modificationGO:00165702510.018
dephosphorylationGO:00163112090.018
regulation of peptidase activityGO:00525471800.018
regulation of protein catabolic processGO:00421761550.018
compound eye developmentGO:004874910.018
calcium ion transportGO:00068161470.018
morphogenesis of embryonic epitheliumGO:001633140.018
nucleocytoplasmic transportGO:00069131760.018
sequestering of metal ionGO:0051238240.018
cellular ion homeostasisGO:00068731680.018
reactive oxygen species biosynthetic processGO:190340940.018
positive regulation of cell migrationGO:00303351720.018
cardiac muscle contractionGO:0060048340.018
gtp metabolic processGO:00460392390.018
neurogenesisGO:00220081690.018
sequestering of calcium ionGO:0051208170.018
taxisGO:00423301570.018
positive regulation of purine nucleotide metabolic processGO:19005442270.018
gtp catabolic processGO:00061842370.018
regulation of anatomical structure morphogenesisGO:00226032860.018
regulation of growthGO:00400081650.018
regulation of kinase activityGO:00435493140.018
regulation of response to external stimulusGO:00321012220.018
mature dendritic cell differentiationGO:009702920.018
positive regulation of cell motilityGO:20001471770.018
modification dependent macromolecule catabolic processGO:00436322120.018
apoptotic signaling pathwayGO:00971902680.018
cytosolic calcium ion homeostasisGO:0051480890.018
regulation of cell migrationGO:00303342890.018
rhythmic behaviorGO:000762220.018
response to lipidGO:00339932060.018
blood circulationGO:00080151130.018
protein modification by small protein conjugationGO:00324463420.017
guanosine containing compound metabolic processGO:19010682440.017
positive regulation of developmental processGO:00510943140.017
protein targetingGO:00066051870.017
blood vessel developmentGO:00015681720.017
negative regulation of phosphorylationGO:00423261740.017
positive regulation of cell differentiationGO:00455972110.017
regulation of dna metabolic processGO:00510521530.017
peptidyl tyrosine phosphorylationGO:00181081700.017
defense response to bacteriumGO:0042742630.017
positive regulation of mapk cascadeGO:00434101900.017
negative regulation of intracellular signal transductionGO:19025321830.017
purine ribonucleoside monophosphate metabolic processGO:00091671860.017
positive regulation of kinase activityGO:00336742040.017
peptidyl tyrosine modificationGO:00182121700.017
activation of immune responseGO:00022531140.017
modification dependent protein catabolic processGO:00199412090.017
negative regulation of hydrolase activityGO:00513461820.017
secretion by cellGO:00329402260.017
lymphocyte activationGO:00466491330.017
Mouse
establishment of protein localization to organelleGO:00725941720.016
regulation of cytoskeleton organizationGO:00514931770.016
cardiovascular system developmentGO:00723582620.016
dna repairGO:00062811980.016
proteasomal protein catabolic processGO:00104981760.016
regulation of actin filament based processGO:00329701410.016
positive regulation of cellular component movementGO:00512721810.016
regulation of nucleotide catabolic processGO:00308112050.016
nucleoside monophosphate metabolic processGO:00091231910.016
ubiquitin dependent protein catabolic processGO:00065112060.016
positive regulation of locomotionGO:00400171860.016
detection of chemical stimulus involved in sensory perceptionGO:0050907330.016
response to hormoneGO:00097251750.016
positive regulation of nucleotide metabolic processGO:00459812300.016
regulation of protein processingGO:00706131500.016
positive regulation of transferase activityGO:00513472270.016
photoreceptor cell differentiationGO:004653020.016
positive regulation of reactive oxygen species biosynthetic processGO:190342820.016
nuclear transportGO:00511691790.016
positive regulation of purine nucleotide catabolic processGO:00331231850.016
protein ubiquitinationGO:00165673140.016
glial cell migrationGO:000834740.016
motor neuron axon guidanceGO:000804520.016
positive regulation of nucleoside metabolic processGO:00459791860.016
negative regulation of apoptotic processGO:00430663160.016
syncytium formation by plasma membrane fusionGO:000076820.016
i kappab kinase nf kappab signalingGO:00072491660.016
myeloid cell differentiationGO:00300991170.016
growthGO:00400072020.016
regulation of multi organism processGO:00439001570.015
embryonic epithelial tube formationGO:000183840.015
cell cycle phase transitionGO:00447701730.015
leukocyte differentiationGO:0002521980.015
negative regulation of protein phosphorylationGO:00019331400.015
cellular calcium ion homeostasisGO:00068741170.015
regulation of ion transportGO:00432691890.015
epithelium migrationGO:00901321190.015
oocyte developmentGO:004859910.015
anterior posterior axis specificationGO:000994820.015
organ formationGO:004864530.015
small molecule biosynthetic processGO:00442831570.015
detection of chemical stimulus involved in sensory perception of smellGO:005091120.015
regulation of endopeptidase activityGO:00525481700.015
response to fungusGO:000962040.015
purine nucleoside monophosphate metabolic processGO:00091261860.015
ribonucleoside monophosphate metabolic processGO:00091611870.015
regulation of reactive oxygen species metabolic processGO:2000377410.015
regulation of protein maturationGO:19033171500.015
microtubule based processGO:00070172100.015
regulation of gtpase activityGO:00430871800.015
cellular response to nitrogen compoundGO:19016991440.015
negative regulation of cell cycleGO:00457861930.015
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.015
regulation of cell developmentGO:00602841610.015
regulation of mitotic cell cycleGO:00073461890.015
peripheral nervous system developmentGO:000742220.015
response to growth factorGO:00708482050.015
regulation of i kappab kinase nf kappab signalingGO:00431221620.015
matingGO:000761810.015
developmental programmed cell deathGO:001062330.015
positive regulation of organelle organizationGO:00106381950.015
multi organism cellular processGO:00447641560.015
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.015
cellular response to organonitrogen compoundGO:00714171240.015
cell cell signalingGO:00072671550.015
response to axon injuryGO:004867810.014
interspecies interaction between organismsGO:00444191560.014
regulation of secretion by cellGO:19035301770.014
adult locomotory behaviorGO:000834410.014
negative regulation of protein processingGO:00109551420.014
single organism carbohydrate metabolic processGO:00447231930.014
cell divisionGO:00513011680.014
regulation of leukocyte activationGO:00026941150.014
protein importGO:00170381300.014
divalent inorganic cation transportGO:00725111580.014
cell growthGO:00160491600.014
cellular response to organic cyclic compoundGO:00714071270.014
cellular protein complex assemblyGO:00436231880.014
posttranscriptional regulation of gene expressionGO:00106082130.014
positive regulation of nucleotide catabolic processGO:00308131850.014
positive regulation of cell cycleGO:00457871400.014
negative regulation of cytokine productionGO:0001818820.014
keratinizationGO:003142420.014
regulation of homeostatic processGO:00328441210.014
positive regulation of reactive oxygen species metabolic processGO:2000379240.014
regulation of anatomical structure sizeGO:00900661010.014
Mouse
positive regulation of cytosolic calcium ion concentrationGO:0007204820.014
microtubule cytoskeleton organizationGO:00002261760.014
protein acylationGO:00435431380.014
neural tube formationGO:000184130.014
regulation of gtp catabolic processGO:00331241800.014
peptidyl lysine modificationGO:00182051440.014
regulation of ion homeostasisGO:2000021730.014
cell part morphogenesisGO:00329901370.014
positive regulation of synaptic transmissionGO:005080640.014
negative regulation of protein maturationGO:19033181420.014
single organism cell adhesionGO:00986021790.014
dna replicationGO:00062601160.014
regulation of membrane potentialGO:0042391950.014
organelle assemblyGO:00709251760.014
protein oligomerizationGO:00512591730.014
endomembrane system organizationGO:00102561960.014
nerve developmentGO:002167540.013
positive regulation of cell cycle processGO:00900681060.013
monocarboxylic acid metabolic processGO:00327871850.013
cation transmembrane transportGO:00986552380.013
epithelial cell differentiationGO:00308551410.013
regulation of protein serine threonine kinase activityGO:00719001790.013
regulation of symbiosis encompassing mutualism through parasitismGO:00439031090.013
regulation of intracellular protein transportGO:00331571230.013
tripartite regional subdivisionGO:000735120.013
anterior posterior axis specification embryoGO:000859520.013
nucleoside monophosphate catabolic processGO:00091251590.013
detection of stimulusGO:0051606850.013
wnt signaling pathwayGO:00160551560.013
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.013
sensory perceptionGO:00076001030.013
regulation of metal ion transportGO:00109591200.013
circulatory system processGO:00030131130.013
atp metabolic processGO:00460341760.013
immune response activating signal transductionGO:0002757900.013
positive regulation of intracellular transportGO:00323881040.013
cellular response to growth factor stimulusGO:00713631970.013
organophosphate biosynthetic processGO:00904071630.013
regulation of protein complex assemblyGO:00432541470.013
rna processingGO:00063962550.013
organonitrogen compound biosynthetic processGO:19015662000.013
anion transportGO:00068201610.013
regulation of cell morphogenesisGO:00226041530.013
positive regulation of protein transportGO:00512221350.013
positive regulation of protein kinase activityGO:00458601900.013
single organismal cell cell adhesionGO:00163371480.013
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.013
response to virusGO:00096151260.013
lung alveolus developmentGO:004828640.013
negative regulation of immune system processGO:00026831360.013
defense response to fungusGO:005083240.013
myoblast fusionGO:000752010.013
stress activated mapk cascadeGO:0051403930.013
organelle fissionGO:00482851490.013
negative regulation of catabolic processGO:00098951040.013
methylationGO:00322591060.013
negative regulation of cell proliferationGO:00082852280.013
organ morphogenesisGO:00098871470.013
peptidyl serine phosphorylationGO:00181051010.013
regulation of stress activated mapk cascadeGO:0032872840.013
positive regulation of gtpase activityGO:00435471660.012
regulation of lipid metabolic processGO:0019216960.012
ameboidal type cell migrationGO:00016671350.012
regulation of meiotic cell cycleGO:005144540.012
metencephalon developmentGO:002203720.012
neuron differentiationGO:00301821380.012
multicellular organismal signalingGO:0035637340.012
circulatory system developmentGO:00723592620.012
carbohydrate derivative biosynthetic processGO:19011372070.012
regulation of mhc class ii biosynthetic processGO:004534640.012
viral processGO:00160321460.012
angiogenesisGO:00015251470.012
protein localization to membraneGO:00726571600.012
regulation of chromosome organizationGO:00330441030.012
regulation of neural precursor cell proliferationGO:200017740.012
carbohydrate metabolic processGO:00059752070.012
cell projection morphogenesisGO:00488581290.012
protein localization to nucleusGO:00345041360.012
peptidyl lysine acetylationGO:00183941010.012
regulation of cysteine type endopeptidase activityGO:20001161270.012
regulation of cell adhesionGO:00301551660.012
negative regulation of synaptic transmissionGO:005080520.012
mhc class ii biosynthetic processGO:004534240.012
viral life cycleGO:00190581320.012
action potentialGO:0001508340.012
organic hydroxy compound metabolic processGO:19016151470.012
cerebellum developmentGO:002154920.012
somitogenesisGO:000175620.012
epithelial cell proliferationGO:00506731280.012
glycoprotein metabolic processGO:00091001100.012
mitochondrion organizationGO:00070051560.012
positive regulation of gtp catabolic processGO:00331261660.012
spinal cord developmentGO:002151040.012
negative regulation of organelle organizationGO:00106391260.012
protein autophosphorylationGO:00467771230.012
regulation of bindingGO:00510981110.012
regulation of epithelial cell proliferationGO:00506781130.012
regulation of synaptic plasticityGO:004816730.012
negative regulation of proteolysisGO:00458611320.012
neuron developmentGO:00486661130.012
sulfur compound metabolic processGO:00067901010.012
oocyte differentiationGO:000999420.012
immune effector processGO:00022521590.012
protein secretionGO:0009306980.012
tissue migrationGO:00901301190.012
carboxylic acid biosynthetic processGO:0046394970.012
regulation of cell cycle phase transitionGO:19019871260.012
neurotransmitter secretionGO:000726940.012
cellular response to lipidGO:00713961270.012
visual behaviorGO:000763220.012
regulation of apoptotic signaling pathwayGO:20012331750.011
morphogenesis of a polarized epitheliumGO:000173830.011
regulation of ras gtpase activityGO:00323181280.011
mitotic cell cycle phase transitionGO:00447721620.011
protein acetylationGO:00064731160.011
ribonucleoside monophosphate catabolic processGO:00091581580.011
jnk cascadeGO:0007254800.011
nitrogen compound transportGO:00717051910.011
stress activated protein kinase signaling cascadeGO:0031098940.011
reproductive processGO:00224141060.011
detection of chemical stimulusGO:0009593550.011
peptidyl serine modificationGO:00182091060.011
regulation of defense responseGO:00313471540.011
neuroblast proliferationGO:000740540.011
positive regulation of secretion by cellGO:19035321080.011
purine nucleoside monophosphate catabolic processGO:00091281580.011
negative regulation of transferase activityGO:00513481240.011
erk1 and erk2 cascadeGO:00703711040.011
cell fate determinationGO:000170930.011
thymus developmentGO:004853830.011
hair follicle morphogenesisGO:003106920.011
chemotaxisGO:00069351570.011
regulation of transporter activityGO:0032409820.011
epidermis morphogenesisGO:004873030.011
cell projection assemblyGO:00300311260.011
regulation of cell activationGO:00508651250.011
response to radiationGO:00093141510.011

VPREB1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
immune system diseaseDOID:29141550.057
hematopoietic system diseaseDOID:741000.030
disease of metabolismDOID:00146672950.027
nervous system diseaseDOID:8634310.027
sensory system diseaseDOID:00501552030.027
musculoskeletal system diseaseDOID:172230.026
disease of cellular proliferationDOID:145661740.020
cancerDOID:1621670.020
central nervous system diseaseDOID:3311860.018
inherited metabolic disorderDOID:6552420.018
eye diseaseDOID:56141490.017
eye and adnexa diseaseDOID:14921500.017
organ system cancerDOID:00506861640.017
neurodegenerative diseaseDOID:12891020.014
connective tissue diseaseDOID:651090.014
retinal diseaseDOID:56791180.014
disease of mental healthDOID:150700.012
bone diseaseDOID:0080001880.012
muscle tissue diseaseDOID:661130.012
muscular diseaseDOID:00800001140.012
primary immunodeficiency diseaseDOID:612360.012
myopathyDOID:4231040.011