Homo sapiens

0 known processes

DNASE1L2

deoxyribonuclease I-like 2

(Aliases: DNAS1L2)

DNASE1L2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
post embryonic developmentGO:000979120.088
cellular amine metabolic processGO:0044106410.078
transmembrane transportGO:00550853990.076
cellular amino acid metabolic processGO:00065201160.071
cellular ketone metabolic processGO:0042180800.070
regulation of cellular component movementGO:00512703340.070
system processGO:00030083490.060
regulation of cellular amine metabolic processGO:0033238110.058
negative regulation of programmed cell deathGO:00430693210.057
enzyme linked receptor protein signaling pathwayGO:00071673030.052
amine metabolic processGO:0009308440.052
organonitrogen compound biosynthetic processGO:19015662000.051
biological adhesionGO:00226103310.049
regulation of cell differentiationGO:00455953930.048
positive regulation of transportGO:00510503360.046
cytoplasmic transportGO:00164823790.046
cell adhesionGO:00071553250.046
regulation of anatomical structure morphogenesisGO:00226032860.046
negative regulation of multicellular organismal processGO:00512413170.045
cellular macromolecule catabolic processGO:00442653800.045
Mouse
inorganic ion transmembrane transportGO:00986602310.044
regulation of cytokine productionGO:00018172320.044
regulation of cell motilityGO:20001452990.044
regulation of cellular amino acid metabolic processGO:000652160.044
cell developmentGO:00484683280.044
Mouse
single organism cellular localizationGO:19025803320.043
negative regulation of apoptotic processGO:00430663160.043
lipid biosynthetic processGO:00086101770.042
segmentationGO:003528240.041
regulation of cellular ketone metabolic processGO:0010565500.041
epithelium developmentGO:00604292270.041
Mouse
ras protein signal transductionGO:0007265730.041
multicellular organismal agingGO:001025930.040
small gtpase mediated signal transductionGO:0007264780.040
nervous system developmentGO:00073992930.040
cellular response to endogenous stimulusGO:00714953360.040
ribonucleoside triphosphate metabolic processGO:00091994120.040
cell morphogenesisGO:00009022960.039
response to growth factorGO:00708482050.039
regulation of locomotionGO:00400123290.038
protein processingGO:00164852260.038
vesicle mediated transportGO:00161923710.038
organophosphate catabolic processGO:00464344300.037
negative regulation of catalytic activityGO:00430863350.037
oogenesisGO:004847720.037
positive regulation of cellular component organizationGO:00511303760.037
negative regulation of cell deathGO:00605483450.037
nucleoside triphosphate metabolic processGO:00091414220.037
regulation of cell migrationGO:00303342890.037
regulation of hormone levelsGO:00108171250.036
actin filament based processGO:00300292240.036
cellular component morphogenesisGO:00329893140.036
determination of adult lifespanGO:000834020.036
protein localization to organelleGO:00333652800.036
purine nucleoside catabolic processGO:00061523980.035
negative regulation of cellular component organizationGO:00511292350.035
glycoprotein metabolic processGO:00091001100.035
positive regulation of protein phosphorylationGO:00019343130.035
protein maturationGO:00516042330.035
regulation of cell adhesionGO:00301551660.035
neuron differentiationGO:00301821380.034
ion transmembrane transportGO:00342203380.034
regulation of cellular component biogenesisGO:00440872810.034
cellular macromolecular complex assemblyGO:00346223240.034
female gamete generationGO:000729220.034
intracellular protein transportGO:00068862700.034
defense responseGO:00069523150.033
membrane organizationGO:00610242920.033
negative regulation of protein metabolic processGO:00512483910.033
positive regulation of cellular amine metabolic processGO:003324070.033
positive regulation of cellular amino acid metabolic processGO:004576430.032
cellular lipid metabolic processGO:00442553030.032
cardiovascular system developmentGO:00723582620.032
cytokine productionGO:00018162470.032
protein catabolic processGO:00301633250.032
purine ribonucleoside metabolic processGO:00461284370.032
regulation of nucleotide metabolic processGO:00061402690.032
negative regulation of developmental processGO:00510932470.031
regulation of cellular response to stressGO:00801352440.031
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.031
locomotory behaviorGO:000762610.031
purine ribonucleoside triphosphate metabolic processGO:00092054110.030
positive regulation of hydrolase activityGO:00513453310.030
regulation of protein transportGO:00512232130.030
regulation of establishment of protein localizationGO:00702012420.030
purine nucleotide catabolic processGO:00061954050.030
regulation of protein localizationGO:00328802960.030
ribonucleoside catabolic processGO:00424544060.030
purine containing compound catabolic processGO:00725234110.030
lipid metabolic processGO:00066293810.030
nucleotide catabolic processGO:00091664080.030
apoptotic signaling pathwayGO:00971902680.030
regulation of cell cycleGO:00517263930.030
purine nucleoside triphosphate catabolic processGO:00091463920.030
negative regulation of cell differentiationGO:00455961710.030
regulation of cytoskeleton organizationGO:00514931770.029
neurogenesisGO:00220081690.029
ribonucleoside triphosphate catabolic processGO:00092033910.029
purine ribonucleotide catabolic processGO:00091544040.029
negative regulation of cellular protein metabolic processGO:00322693530.029
regulation of cell cycle processGO:00105642660.029
chemical homeostasisGO:00488783060.029
carbohydrate derivative biosynthetic processGO:19011372070.028
positive regulation of catabolic processGO:00098963100.028
positive regulation of phosphorylationGO:00423273940.028
glycosyl compound catabolic processGO:19016584130.028
cellular response to growth factor stimulusGO:00713631970.028
purine nucleoside triphosphate metabolic processGO:00091444120.027
guanosine containing compound catabolic processGO:19010692390.027
rho protein signal transductionGO:0007266260.027
cell projection organizationGO:00300302520.027
negative regulation of cell proliferationGO:00082852280.027
positive regulation of cytokine productionGO:00018191670.027
regulation of proteolysisGO:00301622930.026
neuromuscular junction developmentGO:000752830.026
positive regulation of cellular catabolic processGO:00313312840.026
secretion by cellGO:00329402260.025
response to cytokineGO:00340972320.025
purine ribonucleoside catabolic processGO:00461303980.025
positive regulation of aldosterone biosynthetic processGO:003234920.025
small molecule biosynthetic processGO:00442831570.025
endomembrane system organizationGO:00102561960.025
cellular response to dna damage stimulusGO:00069743790.025
regulation of response to external stimulusGO:00321012220.025
mitotic cell cycleGO:00002783260.025
single organism membrane organizationGO:00448022680.025
generation of neuronsGO:00486991520.025
immune responseGO:00069553070.025
ribonucleotide catabolic processGO:00092614050.025
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.024
regulation of purine nucleotide metabolic processGO:19005422640.024
nucleoside phosphate catabolic processGO:19012924120.024
striated muscle contractionGO:0006941520.024
nucleoside catabolic processGO:00091644080.024
regulation of secretionGO:00510461940.024
regulation of nucleotide catabolic processGO:00308112050.024
neurotransmitter secretionGO:000726940.024
carbohydrate metabolic processGO:00059752070.024
mitotic cell cycle processGO:19030472860.023
oxidation reduction processGO:00551143960.023
gtp catabolic processGO:00061842370.023
cell growthGO:00160491600.023
hormone metabolic processGO:0042445610.023
regulation of peptidase activityGO:00525471800.023
positive regulation of immune system processGO:00026842830.023
purine ribonucleoside triphosphate catabolic processGO:00092073910.023
metal ion transportGO:00300012720.023
peripheral nervous system developmentGO:000742220.023
regulation of defense responseGO:00313471540.023
regulation of cell growthGO:00015581350.023
positive regulation of apoptotic processGO:00430652460.022
blastoderm segmentationGO:000735020.022
response to oxygen containing compoundGO:19017003690.022
establishment of protein localization to organelleGO:00725941720.022
chromatin organizationGO:00063253510.022
nuclear transportGO:00511691790.022
positive regulation of cell proliferationGO:00082843010.022
protein targetingGO:00066051870.022
cardiac muscle cell contractionGO:008600340.022
proteolysis involved in cellular protein catabolic processGO:00516032440.022
positive regulation of programmed cell deathGO:00430682490.022
chromatin modificationGO:00165682980.022
negative regulation of hydrolase activityGO:00513461820.021
positive regulation of protein transportGO:00512221350.021
plasma membrane organizationGO:00070091150.021
regulation of nucleoside metabolic processGO:00091182090.021
anion transportGO:00068201610.021
regulation of cell morphogenesisGO:00226041530.021
symbiosis encompassing mutualism through parasitismGO:00444031560.021
negative regulation of phosphorus metabolic processGO:00105632670.021
regulation of cell developmentGO:00602841610.021
negative regulation of cell cycleGO:00457861930.021
cellular protein catabolic processGO:00442572610.021
neuron projection developmentGO:00311751060.021
positive regulation of secretion by cellGO:19035321080.021
regulation of protein kinase activityGO:00458592890.021
negative regulation of male gonad developmentGO:200001910.021
multi organism cellular processGO:00447641560.020
regulation of protein import into nucleusGO:0042306780.020
nucleoside triphosphate catabolic processGO:00091433940.020
regulation of kinase activityGO:00435493140.020
anatomical structure formation involved in morphogenesisGO:00486462840.020
blood circulationGO:00080151130.020
positive regulation of cell migrationGO:00303351720.020
establishment of protein localization to membraneGO:00901501210.020
secretionGO:00469032540.020
positive regulation of cell motilityGO:20001471770.020
memoryGO:000761330.020
monocarboxylic acid metabolic processGO:00327871850.020
gtp metabolic processGO:00460392390.020
regulation of intracellular transportGO:00323861950.020
cellular protein complex assemblyGO:00436231880.020
circulatory system processGO:00030131130.019
positive regulation of nucleoside metabolic processGO:00459791860.019
neuron developmentGO:00486661130.019
ion homeostasisGO:00508012300.019
protein localization to membraneGO:00726571600.019
inorganic cation transmembrane transportGO:00986621940.019
cardiac muscle contractionGO:0060048340.019
cellular response to cytokine stimulusGO:00713451810.019
regulation of sequence specific dna binding transcription factor activityGO:00510902110.019
covalent chromatin modificationGO:00165692540.019
motor neuron axon guidanceGO:000804520.019
regulation of cytoplasmic transportGO:19036491490.019
response to external biotic stimulusGO:00432072610.019
positive regulation of cell deathGO:00109422630.019
mapk cascadeGO:00001652880.019
negative regulation of phosphate metabolic processGO:00459362670.019
cation transportGO:00068123310.019
positive regulation of nucleotide catabolic processGO:00308131850.019
negative regulation of transportGO:00510511760.019
cation homeostasisGO:00550801890.019
positive regulation of nucleotide metabolic processGO:00459812300.019
nucleocytoplasmic transportGO:00069131760.019
interspecies interaction between organismsGO:00444191560.019
cellular amide metabolic processGO:0043603690.019
regulation of body fluid levelsGO:0050878990.018
single organismal cell cell adhesionGO:00163371480.018
innate immune responseGO:00450871780.018
regulation of intracellular protein transportGO:00331571230.018
dephosphorylationGO:00163112090.018
positive regulation of purine nucleotide metabolic processGO:19005442270.018
organ formationGO:004864530.018
maintenance of locationGO:00512351120.018
guanosine containing compound metabolic processGO:19010682440.018
regulation of endopeptidase activityGO:00525481700.018
oocyte differentiationGO:000999420.018
protein importGO:00170381300.018
regulation of wnt signaling pathwayGO:00301111230.018
modification dependent protein catabolic processGO:00199412090.018
positive regulation of cellular component biogenesisGO:00440891580.018
tube developmentGO:00352951250.018
nuclear importGO:00511701060.018
positive regulation of cell differentiationGO:00455972110.018
positive regulation of mapk cascadeGO:00434101900.018
taxisGO:00423301570.018
negative regulation of cellular component movementGO:00512711060.018
signal transduction by phosphorylationGO:00230142970.017
cell morphogenesis involved in differentiationGO:00009041440.017
negative regulation of intracellular signal transductionGO:19025321830.017
regulation of purine nucleotide catabolic processGO:00331212050.017
positive regulation of purine nucleotide catabolic processGO:00331231850.017
protein targeting to nucleusGO:00447441040.017
positive regulation of cell adhesionGO:0045785840.017
single organism nuclear importGO:19025931040.017
wnt signaling pathwayGO:00160551560.017
negative regulation of cellular amine metabolic processGO:003323930.017
regulation of transmembrane transportGO:00347621390.017
response to abiotic stimulusGO:00096283360.017
regulation of gtp catabolic processGO:00331241800.017
epidermis morphogenesisGO:004873030.017
positive regulation of developmental processGO:00510943140.017
reactive oxygen species biosynthetic processGO:190340940.017
posttranscriptional regulation of gene expressionGO:00106082130.017
syncytium formation by plasma membrane fusionGO:000076820.017
negative regulation of organelle organizationGO:00106391260.017
modification dependent macromolecule catabolic processGO:00436322120.017
cell cycle phase transitionGO:00447701730.017
protein localization to plasma membraneGO:0072659930.017
regenerationGO:003109940.017
epithelial cell migrationGO:00106311190.017
microtubule based processGO:00070172100.017
negative regulation of growthGO:0045926970.017
regulation of protein catabolic processGO:00421761550.016
negative regulation of cellular amino acid metabolic processGO:004576320.016
regulation of growthGO:00400081650.016
regulation of ion transportGO:00432691890.016
regulation of epithelial cell migrationGO:0010632930.016
organic hydroxy compound metabolic processGO:19016151470.016
positive regulation of secretionGO:00510471160.016
oocyte developmentGO:004859910.016
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.016
muscle system processGO:0003012810.016
regulation of system processGO:00440571010.016
positive regulation of tooth mineralizationGO:007017220.016
actin mediated cell contractionGO:0070252120.016
response to biotic stimulusGO:00096072760.016
limbic system developmentGO:002176130.016
cell substrate adhesionGO:00315891320.016
canonical wnt signaling pathwayGO:00600701160.016
cell part morphogenesisGO:00329901370.016
regulation of mitotic cell cycleGO:00073461890.016
regulation of protein localization to nucleusGO:1900180850.016
regulation of protein maturationGO:19033171500.016
protein localization to nucleusGO:00345041360.016
actin cytoskeleton organizationGO:00300362070.016
peptide metabolic processGO:0006518510.015
spermatid differentiationGO:004851540.015
negative regulation of cell motilityGO:20001461040.015
regulation of apoptotic signaling pathwayGO:20012331750.015
negative regulation of protein processingGO:00109551420.015
response to lipidGO:00339932060.015
regulation of mapk cascadeGO:00434082620.015
negative regulation of protein maturationGO:19033181420.015
tube morphogenesisGO:0035239950.015
response to other organismGO:00517072610.015
regulation of gtpase activityGO:00430871800.015
cell projection morphogenesisGO:00488581290.015
rna processingGO:00063962550.015
regulation of nucleocytoplasmic transportGO:0046822980.015
lipid localizationGO:00108761060.015
positive regulation of locomotionGO:00400171860.015
nitrogen compound transportGO:00717051910.015
growthGO:00400072020.015
regulation of transferase activityGO:00513383550.015
histone modificationGO:00165702510.015
regulation of axon guidanceGO:190266730.015
response to woundingGO:00096111680.015
anterior posterior axis specificationGO:000994820.015
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.015
chemotaxisGO:00069351570.015
ubiquitin dependent protein catabolic processGO:00065112060.015
urogenital system developmentGO:0001655650.015
positive regulation of organelle organizationGO:00106381950.015
protein oligomerizationGO:00512591730.015
regulation of actin cytoskeleton organizationGO:00329561160.015
detection of stimulusGO:0051606850.014
single organism carbohydrate metabolic processGO:00447231930.014
regulation of immune responseGO:00507762010.014
regulation of small gtpase mediated signal transductionGO:00510561560.014
mitotic cell cycle phase transitionGO:00447721620.014
actin filament based movementGO:0030048170.014
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.014
organelle assemblyGO:00709251760.014
viral life cycleGO:00190581320.014
somatic stem cell maintenanceGO:003501940.014
negative regulation of proteolysisGO:00458611320.014
renal system developmentGO:0072001630.014
myoblast fusionGO:000752010.014
divalent inorganic cation transportGO:00725111580.014
protein import into nucleusGO:00066061040.014
regulation of ras protein signal transductionGO:00465781550.014
regulation of multi organism processGO:00439001570.014
proteasomal protein catabolic processGO:00104981760.014
peptidyl lysine modificationGO:00182051440.014
regulation of actin filament based processGO:00329701410.014
organic acid biosynthetic processGO:0016053970.014
positive regulation of cellular component movementGO:00512721810.014
response to inorganic substanceGO:00100351270.014
negative regulation of cell migrationGO:00303361020.014
cell type specific apoptotic processGO:00972851250.014
tongue developmentGO:004358610.014
regulation of protein targetingGO:1903533910.014
reactive nitrogen species metabolic processGO:200105730.014
inner ear morphogenesisGO:004247240.014
ameboidal type cell migrationGO:00016671350.014
positive regulation of proteolysisGO:00458621420.013
regulation of secretion by cellGO:19035301770.013
protein ubiquitinationGO:00165673140.013
metencephalon developmentGO:002203720.013
regulation of epithelial cell proliferationGO:00506781130.013
regulation of dna metabolic processGO:00510521530.013
fatty acid metabolic processGO:00066311150.013
positive regulation of reactive oxygen species metabolic processGO:2000379240.013
positive regulation of kinase activityGO:00336742040.013
activation of immune responseGO:00022531140.013
regulation of protein complex assemblyGO:00432541470.013
regulation of ras gtpase activityGO:00323181280.013
kidney developmentGO:0001822530.013
cellular response to oxygen containing compoundGO:19017012760.013
endocytosisGO:00068971590.013
response to organic cyclic compoundGO:00140702040.013
regulation of cell substrate adhesionGO:0010810680.013
cell fate determinationGO:000170930.013
cell divisionGO:00513011680.013
dna repairGO:00062811980.013
negative regulation of catabolic processGO:00098951040.013
response to transforming growth factor betaGO:0071559940.013
cation transmembrane transportGO:00986552380.013
ossificationGO:00015031210.013
epithelium migrationGO:00901321190.013
regulation of muscle system processGO:0090257530.013
circulatory system developmentGO:00723592620.013
cellular homeostasisGO:00197251960.013
negative regulation of protein phosphorylationGO:00019331400.013
cerebellum developmentGO:002154920.013
protein secretionGO:0009306980.013
protein modification by small protein conjugationGO:00324463420.013
carboxylic acid biosynthetic processGO:0046394970.013
regulation of protein secretionGO:0050708860.013
central nervous system developmentGO:00074171230.013
response to hormoneGO:00097251750.013
organ morphogenesisGO:00098871470.013
matingGO:000761810.013
positive regulation of transferase activityGO:00513472270.013
positive regulation of intracellular protein transportGO:0090316760.013
epithelial cell differentiationGO:00308551410.012
Mouse
positive regulation of reactive oxygen species biosynthetic processGO:190342820.012
reactive oxygen species metabolic processGO:0072593750.012
regulation of hydrogen peroxide mediated programmed cell deathGO:190129840.012
microtubule cytoskeleton organizationGO:00002261760.012
mitochondrion organizationGO:00070051560.012
endosomal transportGO:00161971290.012
regulation of cell projection organizationGO:00313441070.012
regulation of cell cell adhesionGO:0022407570.012
regulation of neural precursor cell proliferationGO:200017740.012
anterior posterior axis specification embryoGO:000859520.012
compound eye developmentGO:004874910.012
positive regulation of aldosterone metabolic processGO:003234620.012
g protein coupled receptor signaling pathwayGO:00071862070.012
tissue migrationGO:00901301190.012
cartilage condensationGO:000150210.012
monovalent inorganic cation transportGO:00156721280.012
cell projection assemblyGO:00300311260.012
regulation of cellular protein catabolic processGO:1903362960.012
embryonic placenta developmentGO:000189210.012
hindbrain developmentGO:003090230.012
hindlimb morphogenesisGO:003513720.012
negative regulation of cellular catabolic processGO:0031330830.012
cellular modified amino acid metabolic processGO:0006575640.012
negative regulation of cell growthGO:0030308830.012
negative regulation of phosphorylationGO:00423261740.012
intrinsic apoptotic signaling pathwayGO:00971931270.012
post embryonic organ developmentGO:004856910.012
positive regulation of ras gtpase activityGO:00323201170.012
t cell differentiation in thymusGO:003307740.012
regulation of cellular component sizeGO:0032535820.012
cellular cation homeostasisGO:00300031630.012
negative regulation of protein modification processGO:00314002000.012
forebrain neuron differentiationGO:002187930.012
establishment of protein localization to plasma membraneGO:0090002680.012
sulfur compound metabolic processGO:00067901010.012
regulation of neuron differentiationGO:0045664700.012
regulation of protein processingGO:00706131500.012
regulation of reactive oxygen species biosynthetic processGO:190342630.012
oxidative stress induced premature senescenceGO:009040330.012
regulation of i kappab kinase nf kappab signalingGO:00431221620.012
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.012
muscle contractionGO:0006936730.011
lipid transportGO:0006869900.011
glycoprotein biosynthetic processGO:0009101910.011
forebrain generation of neuronsGO:002187230.011
positive regulation of immune responseGO:00507781590.011
sex determinationGO:000753030.011
neurological system processGO:00508771630.011
positive regulation of intracellular transportGO:00323881040.011
cell activationGO:00017752130.011
cellular metal ion homeostasisGO:00068751460.011
reproductive processGO:00224141060.011
alcohol metabolic processGO:00060661140.011
adult locomotory behaviorGO:000834410.011
negative regulation of cell cycle processGO:00109481210.011
morphogenesis of embryonic epitheliumGO:001633140.011
hormone secretionGO:0046879650.011
tripartite regional subdivisionGO:000735120.011
mesonephric duct developmentGO:007217730.011
regulation of anatomical structure sizeGO:00900661010.011
negative regulation of response to external stimulusGO:0032102830.011
spermatid developmentGO:000728640.011
regulation of axon extension involved in axon guidanceGO:004884120.011
wound healingGO:00420601150.011
regulation of chromosome organizationGO:00330441030.011
phospholipid metabolic processGO:0006644990.011
regulation of neurotransmitter secretionGO:004692830.011
cell proliferation in forebrainGO:002184610.011
extrinsic apoptotic signaling pathwayGO:00971911190.011
jnk cascadeGO:0007254800.011
positive regulation of cell cycle processGO:00900681060.011
positive regulation of gtpase activityGO:00435471660.011
response to radiationGO:00093141510.011
protein acylationGO:00435431380.011
cell matrix adhesionGO:0007160850.011
stress activated mapk cascadeGO:0051403930.011
regulation of reactive oxygen species metabolic processGO:2000377410.011
tissue morphogenesisGO:0048729960.011
digestive system developmentGO:0055123750.011
negative regulation of transferase activityGO:00513481240.011
immune system developmentGO:00025201950.011
regulation of ion transmembrane transportGO:00347651320.011
positive regulation of insulin like growth factor receptor signaling pathwayGO:004356840.011
positive regulation of hormone biosynthetic processGO:004688640.011
negative regulation of immune system processGO:00026831360.011
rna splicingGO:00083801310.011
negative regulation of locomotionGO:00400131180.011
purine ribonucleoside monophosphate metabolic processGO:00091671860.011
regulation of cell divisionGO:00513021160.011
photoreceptor cell differentiationGO:004653020.011
renin secretion into blood streamGO:000200110.011

DNASE1L2 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.029
nervous system diseaseDOID:8634310.025
sensory system diseaseDOID:00501552030.025
eye and adnexa diseaseDOID:14921500.019
eye diseaseDOID:56141490.019
inherited metabolic disorderDOID:6552420.017
central nervous system diseaseDOID:3311860.015
immune system diseaseDOID:29141550.015
Human
disease of cellular proliferationDOID:145661740.014
cancerDOID:1621670.013
retinal diseaseDOID:56791180.012
musculoskeletal system diseaseDOID:172230.012
Human
organ system cancerDOID:00506861640.012
neurodegenerative diseaseDOID:12891020.011
retinal degenerationDOID:8466890.011