Homo sapiens

6 known processes

SPG11

spastic paraplegia 11 (autosomal recessive)

(Aliases: DKFZp762B1512,FLJ21439,KIAA1840)

SPG11 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
post embryonic developmentGO:000979120.048
cellular macromolecule catabolic processGO:00442653800.034
regulation of cellular amino acid metabolic processGO:000652160.034
cytoplasmic transportGO:00164823790.034
ras protein signal transductionGO:0007265730.033
cellular amino acid metabolic processGO:00065201160.032
small gtpase mediated signal transductionGO:0007264780.032
multicellular organismal agingGO:001025930.031
negative regulation of protein metabolic processGO:00512483910.031
negative regulation of catalytic activityGO:00430863350.030
determination of adult lifespanGO:000834020.030
negative regulation of cellular protein metabolic processGO:00322693530.028
amine metabolic processGO:0009308440.027
cellular response to endogenous stimulusGO:00714953360.026
nucleoside catabolic processGO:00091644080.026
regulation of cellular amine metabolic processGO:0033238110.026
female gamete generationGO:000729220.026
cellular response to dna damage stimulusGO:00069743790.026
dephosphorylationGO:00163112090.025
cellular amine metabolic processGO:0044106410.025
proteolysis involved in cellular protein catabolic processGO:00516032440.025
protein catabolic processGO:00301633250.025
negative regulation of phosphorus metabolic processGO:00105632670.024
oogenesisGO:004847720.024
cellular lipid metabolic processGO:00442553030.024
protein modification by small protein conjugationGO:00324463420.024
vesicle mediated transportGO:00161923710.024
regulation of cellular ketone metabolic processGO:0010565500.023
single organism cellular localizationGO:19025803320.023
protein localization to organelleGO:00333652800.023
cellular ketone metabolic processGO:0042180800.023
locomotory behaviorGO:000762610.023
chromatin organizationGO:00063253510.023
regulation of purine nucleotide metabolic processGO:19005422640.022
positive regulation of hydrolase activityGO:00513453310.022
nucleoside triphosphate metabolic processGO:00091414220.022
covalent chromatin modificationGO:00165692540.022
glycosyl compound catabolic processGO:19016584130.022
neuromuscular junction developmentGO:000752830.022
actin filament based processGO:00300292240.021
meiosis iGO:000712740.021
regulation of kinase activityGO:00435493140.021
protein ubiquitinationGO:00165673140.021
immune responseGO:00069553070.021
positive regulation of cellular catabolic processGO:00313312840.020
rho protein signal transductionGO:0007266260.020
segmentationGO:003528240.020
nucleoside triphosphate catabolic processGO:00091433940.020
positive regulation of nucleotide metabolic processGO:00459812300.020
ribonucleotide catabolic processGO:00092614050.020
adult locomotory behaviorGO:000834410.020
positive regulation of cellular amine metabolic processGO:003324070.020
cellular protein catabolic processGO:00442572610.020
biological adhesionGO:00226103310.020
lipid metabolic processGO:00066293810.019
cellular macromolecular complex assemblyGO:00346223240.019
purine ribonucleoside metabolic processGO:00461284370.019
ubiquitin dependent protein catabolic processGO:00065112060.019
histone modificationGO:00165702510.019
positive regulation of cellular amino acid metabolic processGO:004576430.019
negative regulation of phosphate metabolic processGO:00459362670.019
organophosphate catabolic processGO:00464344300.019
modification dependent macromolecule catabolic processGO:00436322120.019
modification dependent protein catabolic processGO:00199412090.019
purine containing compound catabolic processGO:00725234110.019
ribonucleoside triphosphate catabolic processGO:00092033910.019
positive regulation of catabolic processGO:00098963100.019
purine nucleotide catabolic processGO:00061954050.019
regulation of transferase activityGO:00513383550.018
maintenance of locationGO:00512351120.018
regulation of proteolysisGO:00301622930.018
system processGO:00030083490.018
ribonucleoside triphosphate metabolic processGO:00091994120.018
regulation of protein localizationGO:00328802960.018
dna repairGO:00062811980.018
positive regulation of transportGO:00510503360.018
purine nucleoside triphosphate metabolic processGO:00091444120.018
carbohydrate derivative biosynthetic processGO:19011372070.018
nervous system developmentGO:00073992930.018
response to oxygen containing compoundGO:19017003690.018
positive regulation of immune system processGO:00026842830.018
purine ribonucleotide catabolic processGO:00091544040.018
purine ribonucleoside catabolic processGO:00461303980.018
nucleotide catabolic processGO:00091664080.017
cellular protein complex assemblyGO:00436231880.017
negative regulation of hydrolase activityGO:00513461820.017
ribonucleoside catabolic processGO:00424544060.017
regulation of establishment of protein localizationGO:00702012420.017
transmembrane transportGO:00550853990.017
regenerationGO:003109940.017
positive regulation of purine nucleotide metabolic processGO:19005442270.017
positive regulation of cellular component organizationGO:00511303760.017
negative regulation of protein modification processGO:00314002000.017
carbohydrate metabolic processGO:00059752070.017
mitotic cell cycleGO:00002783260.017
intracellular protein transportGO:00068862700.017
nucleoside phosphate catabolic processGO:19012924120.017
negative regulation of intracellular signal transductionGO:19025321830.017
cellular response to oxygen containing compoundGO:19017012760.017
regulation of nucleotide metabolic processGO:00061402690.017
regulation of cell differentiationGO:00455953930.017
single organism membrane organizationGO:00448022680.017
regulation of cell cycleGO:00517263930.017
positive regulation of cell proliferationGO:00082843010.017
purine nucleoside triphosphate catabolic processGO:00091463920.016
cell adhesionGO:00071553250.016
positive regulation of developmental processGO:00510943140.016
guanosine containing compound catabolic processGO:19010692390.016
purine nucleoside catabolic processGO:00061523980.016
chromatin modificationGO:00165682980.016
blastoderm segmentationGO:000735020.016
cell morphogenesisGO:00009022960.016
protein processingGO:00164852260.016
membrane organizationGO:00610242920.016
nucleocytoplasmic transportGO:00069131760.016
positive regulation of nucleoside metabolic processGO:00459791860.016
negative regulation of multicellular organismal processGO:00512413170.016
negative regulation of developmental processGO:00510932470.015
actin cytoskeleton organizationGO:00300362070.015
innate immune responseGO:00450871780.015
regulation of protein catabolic processGO:00421761550.015
regulation of cellular component biogenesisGO:00440872810.015
cellular component morphogenesisGO:00329893140.015
cell projection organizationGO:00300302520.015
purine ribonucleoside triphosphate metabolic processGO:00092054110.015
regulation of cell cycle processGO:00105642660.015
positive regulation of gtpase activityGO:00435471660.015
spermatid differentiationGO:004851540.015
mapk cascadeGO:00001652880.015
phospholipid metabolic processGO:0006644990.015
glycoprotein metabolic processGO:00091001100.015
glycerolipid metabolic processGO:00464861070.015
oocyte developmentGO:004859910.015
regulation of nucleoside metabolic processGO:00091182090.015
protein maturationGO:00516042330.015
chemical homeostasisGO:00488783060.014
defense responseGO:00069523150.014
oocyte differentiationGO:000999420.014
hematopoietic stem cell differentiationGO:006021840.014
symbiosis encompassing mutualism through parasitismGO:00444031560.014
posttranscriptional regulation of gene expressionGO:00106082130.014
regulation of protein kinase activityGO:00458592890.014
memoryGO:000761330.014
apoptotic signaling pathwayGO:00971902680.014
positive regulation of phosphorylationGO:00423273940.014
regulation of cellular component movementGO:00512703340.014
regulation of gtpase activityGO:00430871800.014
reactive oxygen species biosynthetic processGO:190340940.014
nerve developmentGO:002167540.014
mitotic cell cycle processGO:19030472860.014
protein localization to nucleusGO:00345041360.014
regulation of cellular response to stressGO:00801352440.014
signal transduction by phosphorylationGO:00230142970.014
regulation of protein transportGO:00512232130.014
nitrogen compound transportGO:00717051910.014
response to abiotic stimulusGO:00096283360.014
guanosine containing compound metabolic processGO:19010682440.014
endomembrane system organizationGO:00102561960.014
metencephalon developmentGO:002203720.014
cell projection assemblyGO:00300311260.013
regulation of cytokine productionGO:00018172320.013
compound eye developmentGO:004874910.013
response to nitrogen compoundGO:19016981840.013
purine ribonucleoside triphosphate catabolic processGO:00092073910.013
gtp metabolic processGO:00460392390.013
negative regulation of cell deathGO:00605483450.013
positive regulation of purine nucleotide catabolic processGO:00331231850.013
regulation of cytoskeleton organizationGO:00514931770.013
response to axon injuryGO:004867810.013
metal ion transportGO:00300012720.013
cellular response to organonitrogen compoundGO:00714171240.013
peripheral nervous system developmentGO:000742220.013
negative regulation of cellular component organizationGO:00511292350.013
positive regulation of cell differentiationGO:00455972110.013
regulation of intracellular transportGO:00323861950.013
protein targetingGO:00066051870.013
cation transportGO:00068123310.013
glycerophospholipid metabolic processGO:0006650840.013
regulation of purine nucleotide catabolic processGO:00331212050.013
release of cytoplasmic sequestered nf kappabGO:000858840.013
regulation of ras gtpase activityGO:00323181280.013
matingGO:000761810.013
ion homeostasisGO:00508012300.013
rab protein signal transductionGO:003248240.013
rhythmic behaviorGO:000762220.013
tissue regenerationGO:004224630.012
ion transmembrane transportGO:00342203380.012
proteasomal protein catabolic processGO:00104981760.012
gtp catabolic processGO:00061842370.012
limbic system developmentGO:002176130.012
negative regulation of cellular amino acid metabolic processGO:004576320.012
morphogenesis of embryonic epitheliumGO:001633140.012
circadian behaviorGO:004851220.012
lipid biosynthetic processGO:00086101770.012
negative regulation of transferase activityGO:00513481240.012
hindbrain developmentGO:003090230.012
microtubule based processGO:00070172100.012
cellular response to growth factor stimulusGO:00713631970.012
negative regulation of cellular amine metabolic processGO:003323930.012
inner ear morphogenesisGO:004247240.012
nuclear transportGO:00511691790.012
positive regulation of ras gtpase activityGO:00323201170.012
response to other organismGO:00517072610.012
regulation of sequence specific dna binding transcription factor activityGO:00510902110.012
cell growthGO:00160491600.012
protein localization to membraneGO:00726571600.012
small molecule biosynthetic processGO:00442831570.012
regulation of cell migrationGO:00303342890.012
multi organism cellular processGO:00447641560.012
wnt signaling pathwayGO:00160551560.012
endosomal transportGO:00161971290.012
reactive oxygen species metabolic processGO:0072593750.012
cerebellum developmentGO:002154920.012
regulation of reactive oxygen species biosynthetic processGO:190342630.012
sequestering of calcium ionGO:0051208170.012
anatomical structure formation involved in morphogenesisGO:00486462840.012
canonical wnt signaling pathwayGO:00600701160.012
positive regulation of programmed cell deathGO:00430682490.012
rna processingGO:00063962550.012
establishment of protein localization to organelleGO:00725941720.012
cell cycle phase transitionGO:00447701730.011
positive regulation of cell cycleGO:00457871400.011
neurological system processGO:00508771630.011
negative regulation of programmed cell deathGO:00430693210.011
embryonic epithelial tube formationGO:000183840.011
regulation of growthGO:00400081650.011
cation transmembrane transportGO:00986552380.011
neuroblast proliferationGO:000740540.011
positive regulation of nucleotide catabolic processGO:00308131850.011
protein deubiquitinationGO:0016579790.011
interspecies interaction between organismsGO:00444191560.011
organophosphate biosynthetic processGO:00904071630.011
actin mediated cell contractionGO:0070252120.011
positive regulation of protein phosphorylationGO:00019343130.011
actin filament based movementGO:0030048170.011
immune effector processGO:00022521590.011
motor neuron axon guidanceGO:000804520.011
cell divisionGO:00513011680.011
cardiac muscle cell contractionGO:008600340.011
response to biotic stimulusGO:00096072760.011
positive regulation of organelle organizationGO:00106381950.011
response to growth factorGO:00708482050.011
regulation of cell developmentGO:00602841610.011
regulation of mapk cascadeGO:00434082620.011
regulation of nucleotide catabolic processGO:00308112050.011
regulation of protein processingGO:00706131500.011
spermatid developmentGO:000728640.011
regulation of anatomical structure morphogenesisGO:00226032860.011
morphogenesis of a polarized epitheliumGO:000173830.011
inorganic ion transmembrane transportGO:00986602310.011
regulation of gtp catabolic processGO:00331241800.011
glycoprotein biosynthetic processGO:0009101910.011
response to external biotic stimulusGO:00432072610.011
reactive nitrogen species metabolic processGO:200105730.011
cation homeostasisGO:00550801890.011
single organism cell adhesionGO:00986021790.011
response to organonitrogen compoundGO:00102431560.011
protein oligomerizationGO:00512591730.011
negative regulation of organelle organizationGO:00106391260.011
negative regulation of cell cycleGO:00457861930.011
sequestering of metal ionGO:0051238240.011
regulation of locomotionGO:00400123290.011
viral processGO:00160321460.011
negative regulation of catabolic processGO:00098951040.011
cellular homeostasisGO:00197251960.011
organelle fissionGO:00482851490.011
cell developmentGO:00484683280.011
regulation of cell morphogenesisGO:00226041530.011
negative regulation of protein processingGO:00109551420.011
regulation of protein maturationGO:19033171500.011
secretionGO:00469032540.011
regulation of dna metabolic processGO:00510521530.011
protein localization to plasma membraneGO:0072659930.011
regulation of ras protein signal transductionGO:00465781550.011
lipid localizationGO:00108761060.011
hemopoiesisGO:00300971800.011
anterior posterior axis specificationGO:000994820.011
regulation of immune responseGO:00507762010.011
cellular response to nitrogen compoundGO:19016991440.011
positive regulation of reactive oxygen species biosynthetic processGO:190342820.011
regulation of multi organism processGO:00439001570.011
regulation of neural precursor cell proliferationGO:200017740.011
regulation of cell motilityGO:20001452990.011
positive regulation of apoptotic processGO:00430652460.011
organelle assemblyGO:00709251760.011
negative regulation of protein maturationGO:19033181420.011
negative regulation of cell differentiationGO:00455961710.011
negative regulation of phosphorylationGO:00423261740.010
regulation of reactive oxygen species metabolic processGO:2000377410.010
negative regulation of transportGO:00510511760.010
anion transportGO:00068201610.010
viral life cycleGO:00190581320.010
tripartite regional subdivisionGO:000735120.010
negative regulation of apoptotic processGO:00430663160.010
response to virusGO:00096151260.010
divalent inorganic cation transportGO:00725111580.010
regulation of response to external stimulusGO:00321012220.010
regulation of synaptic plasticityGO:004816730.010
regulation of meiotic cell cycleGO:005144540.010
ossificationGO:00015031210.010
neurotransmitter secretionGO:000726940.010
regulation of viral processGO:00507921030.010
negative regulation of phosphatase activityGO:0010923610.010
enzyme linked receptor protein signaling pathwayGO:00071673030.010
cell part morphogenesisGO:00329901370.010
generation of neuronsGO:00486991520.010
establishment of protein localization to membraneGO:00901501210.010

SPG11 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.046
inherited metabolic disorderDOID:6552420.043
musculoskeletal system diseaseDOID:172230.022
organ system cancerDOID:00506861640.018
disease of cellular proliferationDOID:145661740.018
cancerDOID:1621670.018
immune system diseaseDOID:29141550.017
sensory system diseaseDOID:00501552030.016
nervous system diseaseDOID:8634310.016
central nervous system diseaseDOID:3311860.015
muscle tissue diseaseDOID:661130.014
muscular diseaseDOID:00800001140.014
cardiovascular system diseaseDOID:12871060.012
eye and adnexa diseaseDOID:14921500.012
hematopoietic system diseaseDOID:741000.012
myopathyDOID:4231040.012
eye diseaseDOID:56141490.012
connective tissue diseaseDOID:651090.012
disease of mental healthDOID:150700.011
neurodegenerative diseaseDOID:12891020.011
retinal diseaseDOID:56791180.011
carbohydrate metabolic disorderDOID:2978550.010
hereditary spastic paraplegiaDOID:2476190.003
paraplegiaDOID:607190.003