Homo sapiens

0 known processes

PLIN4

perilipin 4

(Aliases: KIAA1881,S3-12)

PLIN4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
lipid metabolic processGO:00066293810.167
regulation of cellular component movementGO:00512703340.080
lipid catabolic processGO:0016042840.079
monocarboxylic acid metabolic processGO:00327871850.078
cellular lipid metabolic processGO:00442553030.071
cytokine productionGO:00018162470.068
regulation of cellular ketone metabolic processGO:0010565500.066
fatty acid metabolic processGO:00066311150.062
carbohydrate metabolic processGO:00059752070.060
cellular amino acid metabolic processGO:00065201160.060
biological adhesionGO:00226103310.057
cellular amine metabolic processGO:0044106410.057
cellular ketone metabolic processGO:0042180800.055
amine metabolic processGO:0009308440.052
single organism carbohydrate metabolic processGO:00447231930.051
post embryonic developmentGO:000979120.051
cellular response to endogenous stimulusGO:00714953360.050
female gamete generationGO:000729220.049
regulation of cellular amine metabolic processGO:0033238110.048
oxidation reduction processGO:00551143960.047
system processGO:00030083490.046
cation transportGO:00068123310.046
negative regulation of transportGO:00510511760.046
lipid biosynthetic processGO:00086101770.045
regulation of cellular amino acid metabolic processGO:000652160.045
cell developmentGO:00484683280.044
ras protein signal transductionGO:0007265730.044
regulation of cytokine productionGO:00018172320.043
oogenesisGO:004847720.043
chemical homeostasisGO:00488783060.043
positive regulation of catabolic processGO:00098963100.042
regulation of establishment of protein localizationGO:00702012420.041
cell adhesionGO:00071553250.041
locomotory behaviorGO:000762610.040
cellular lipid catabolic processGO:0044242650.039
positive regulation of hydrolase activityGO:00513453310.039
positive regulation of cellular amino acid metabolic processGO:004576430.038
positive regulation of protein phosphorylationGO:00019343130.038
transmembrane transportGO:00550853990.037
positive regulation of transportGO:00510503360.037
ion homeostasisGO:00508012300.037
regulation of protein transportGO:00512232130.037
lipid localizationGO:00108761060.037
positive regulation of cellular catabolic processGO:00313312840.037
purine ribonucleotide catabolic processGO:00091544040.037
small molecule biosynthetic processGO:00442831570.037
multicellular organismal agingGO:001025930.037
negative regulation of protein metabolic processGO:00512483910.037
cytoplasmic transportGO:00164823790.037
nucleoside catabolic processGO:00091644080.036
purine ribonucleoside catabolic processGO:00461303980.036
single organism cellular localizationGO:19025803320.036
regulation of protein localizationGO:00328802960.036
negative regulation of phosphate metabolic processGO:00459362670.035
purine nucleoside catabolic processGO:00061523980.035
negative regulation of multicellular organismal processGO:00512413170.035
negative regulation of cellular protein metabolic processGO:00322693530.035
regulation of cell motilityGO:20001452990.035
determination of adult lifespanGO:000834020.035
nucleoside phosphate catabolic processGO:19012924120.034
regulation of anatomical structure morphogenesisGO:00226032860.034
negative regulation of catalytic activityGO:00430863350.034
purine ribonucleoside metabolic processGO:00461284370.034
organophosphate catabolic processGO:00464344300.034
regulation of cell adhesionGO:00301551660.034
glycerolipid metabolic processGO:00464861070.034
glycosyl compound catabolic processGO:19016584130.033
purine ribonucleoside triphosphate metabolic processGO:00092054110.033
positive regulation of phosphorylationGO:00423273940.033
alcohol metabolic processGO:00060661140.033
negative regulation of phosphorus metabolic processGO:00105632670.033
positive regulation of cellular component organizationGO:00511303760.033
ribonucleoside catabolic processGO:00424544060.033
ribonucleoside triphosphate metabolic processGO:00091994120.033
regulation of cellular component biogenesisGO:00440872810.033
ribonucleoside triphosphate catabolic processGO:00092033910.032
positive regulation of cellular amine metabolic processGO:003324070.032
immune responseGO:00069553070.032
purine nucleotide catabolic processGO:00061954050.032
purine nucleoside triphosphate catabolic processGO:00091463920.032
regulation of nucleotide metabolic processGO:00061402690.032
purine nucleoside triphosphate metabolic processGO:00091444120.032
nucleoside triphosphate metabolic processGO:00091414220.032
apoptotic signaling pathwayGO:00971902680.032
secretionGO:00469032540.032
nucleotide catabolic processGO:00091664080.031
response to oxygen containing compoundGO:19017003690.031
regulation of locomotionGO:00400123290.031
ion transmembrane transportGO:00342203380.031
negative regulation of cellular component organizationGO:00511292350.031
regulation of secretion by cellGO:19035301770.031
regulation of lipid metabolic processGO:0019216960.030
regulation of transferase activityGO:00513383550.030
response to lipidGO:00339932060.030
single organism cell adhesionGO:00986021790.029
nucleoside triphosphate catabolic processGO:00091433940.029
purine containing compound catabolic processGO:00725234110.029
metal ion transportGO:00300012720.029
response to abiotic stimulusGO:00096283360.029
regulation of kinase activityGO:00435493140.029
negative regulation of developmental processGO:00510932470.028
organic hydroxy compound metabolic processGO:19016151470.028
cellular component morphogenesisGO:00329893140.028
purine ribonucleoside triphosphate catabolic processGO:00092073910.028
cellular macromolecule catabolic processGO:00442653800.028
vesicle mediated transportGO:00161923710.027
maintenance of locationGO:00512351120.027
regulation of cellular response to stressGO:00801352440.027
positive regulation of immune system processGO:00026842830.027
ribonucleotide catabolic processGO:00092614050.027
actin filament based processGO:00300292240.027
regulation of secretionGO:00510461940.027
small gtpase mediated signal transductionGO:0007264780.027
regulation of mapk cascadeGO:00434082620.027
negative regulation of cell deathGO:00605483450.026
intracellular protein transportGO:00068862700.026
cellular response to oxygen containing compoundGO:19017012760.026
response to hormoneGO:00097251750.026
regenerationGO:003109940.026
cell morphogenesisGO:00009022960.026
regulation of i kappab kinase nf kappab signalingGO:00431221620.025
regulation of protein kinase activityGO:00458592890.025
cellular protein catabolic processGO:00442572610.025
regulation of cell differentiationGO:00455953930.025
negative regulation of intracellular signal transductionGO:19025321830.025
negative regulation of protein modification processGO:00314002000.025
inorganic ion transmembrane transportGO:00986602310.025
response to nitrogen compoundGO:19016981840.025
regulation of cell migrationGO:00303342890.025
cellular response to organonitrogen compoundGO:00714171240.025
neuromuscular junction developmentGO:000752830.024
rho protein signal transductionGO:0007266260.024
positive regulation of programmed cell deathGO:00430682490.024
membrane organizationGO:00610242920.024
single organism membrane organizationGO:00448022680.024
positive regulation of nucleotide metabolic processGO:00459812300.024
regulation of response to external stimulusGO:00321012220.024
innate immune responseGO:00450871780.023
carbohydrate derivative biosynthetic processGO:19011372070.023
small molecule catabolic processGO:0044282920.023
gtp metabolic processGO:00460392390.023
cell activationGO:00017752130.023
regulation of cell cycleGO:00517263930.023
negative regulation of cellular amine metabolic processGO:003323930.023
regulation of lipid catabolic processGO:0050994230.023
actin cytoskeleton organizationGO:00300362070.022
positive regulation of transferase activityGO:00513472270.022
cellular carbohydrate metabolic processGO:0044262840.022
cellular response to dna damage stimulusGO:00069743790.022
mitotic cell cycleGO:00002783260.022
cellular macromolecular complex assemblyGO:00346223240.022
secretion by cellGO:00329402260.022
negative regulation of cell proliferationGO:00082852280.022
organonitrogen compound biosynthetic processGO:19015662000.022
divalent inorganic cation homeostasisGO:00725071360.022
positive regulation of cytokine productionGO:00018191670.022
proteolysis involved in cellular protein catabolic processGO:00516032440.022
cellular response to cytokine stimulusGO:00713451810.022
guanosine containing compound catabolic processGO:19010692390.021
positive regulation of apoptotic processGO:00430652460.021
protein catabolic processGO:00301633250.021
inorganic cation transmembrane transportGO:00986621940.021
hindbrain developmentGO:003090230.021
lipid transportGO:0006869900.021
negative regulation of cellular amino acid metabolic processGO:004576320.021
response to cytokineGO:00340972320.021
positive regulation of kinase activityGO:00336742040.021
defense responseGO:00069523150.021
protein localization to membraneGO:00726571600.021
response to organic cyclic compoundGO:00140702040.021
positive regulation of purine nucleotide metabolic processGO:19005442270.021
negative regulation of phosphorylationGO:00423261740.021
nervous system developmentGO:00073992930.021
coagulationGO:0050817780.021
muscle contractionGO:0006936730.021
negative regulation of programmed cell deathGO:00430693210.021
single organismal cell cell adhesionGO:00163371480.020
cardiac muscle cell contractionGO:008600340.020
enzyme linked receptor protein signaling pathwayGO:00071673030.020
regulation of proteolysisGO:00301622930.020
organic hydroxy compound transportGO:0015850630.020
regulation of purine nucleotide metabolic processGO:19005422640.020
protein oligomerizationGO:00512591730.020
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.020
regulation of intracellular transportGO:00323861950.020
protein secretionGO:0009306980.020
segmentationGO:003528240.020
cellular protein complex assemblyGO:00436231880.020
regulation of small gtpase mediated signal transductionGO:00510561560.020
protein processingGO:00164852260.020
anion transportGO:00068201610.020
nitrogen compound transportGO:00717051910.019
response to biotic stimulusGO:00096072760.019
regulation of ion transportGO:00432691890.019
protein maturationGO:00516042330.019
i kappab kinase nf kappab signalingGO:00072491660.019
muscle system processGO:0003012810.019
cellular homeostasisGO:00197251960.019
positive regulation of nucleotide catabolic processGO:00308131850.019
protein modification by small protein conjugationGO:00324463420.019
mitotic cell cycle processGO:19030472860.019
immune system developmentGO:00025201950.019
divalent metal ion transportGO:00708381520.019
blood circulationGO:00080151130.019
cell projection organizationGO:00300302520.019
regulation of cell cycle processGO:00105642660.019
memoryGO:000761330.019
positive regulation of gtp catabolic processGO:00331261660.018
glycerolipid biosynthetic processGO:0045017510.018
mapk cascadeGO:00001652880.018
positive regulation of mapk cascadeGO:00434101900.018
negative regulation of cell differentiationGO:00455961710.018
regulation of reactive oxygen species metabolic processGO:2000377410.018
positive regulation of protein kinase activityGO:00458601900.018
blastoderm segmentationGO:000735020.018
regulation of protein serine threonine kinase activityGO:00719001790.018
regulation of gtpase activityGO:00430871800.018
spermatid differentiationGO:004851540.018
positive regulation of organelle organizationGO:00106381950.018
positive regulation of purine nucleotide catabolic processGO:00331231850.018
negative regulation of synaptic transmissionGO:005080520.018
positive regulation of nucleoside metabolic processGO:00459791860.018
glycoprotein metabolic processGO:00091001100.018
protein localization to organelleGO:00333652800.018
guanosine containing compound metabolic processGO:19010682440.018
regulation of nucleoside metabolic processGO:00091182090.018
positive regulation of cell deathGO:00109422630.018
cellular response to nitrogen compoundGO:19016991440.017
response to organonitrogen compoundGO:00102431560.017
endomembrane system organizationGO:00102561960.017
regulation of protein secretionGO:0050708860.017
wound healingGO:00420601150.017
striated muscle contractionGO:0006941520.017
adult locomotory behaviorGO:000834410.017
gtp catabolic processGO:00061842370.017
histone modificationGO:00165702510.017
regulation of system processGO:00440571010.017
lipid modificationGO:0030258840.017
peripheral nervous system developmentGO:000742220.017
regulation of cytoskeleton organizationGO:00514931770.017
hematopoietic or lymphoid organ developmentGO:00485341860.017
anterior posterior axis specificationGO:000994820.017
regulation of dna metabolic processGO:00510521530.017
neutral lipid metabolic processGO:0006638270.017
positive regulation of gtpase activityGO:00435471660.017
anterior posterior axis specification embryoGO:000859520.017
response to external biotic stimulusGO:00432072610.017
positive regulation of monocyte chemotactic protein 1 productionGO:007163930.017
regulation of nucleotide catabolic processGO:00308112050.017
response to other organismGO:00517072610.017
response to woundingGO:00096111680.017
regulation of transmembrane transportGO:00347621390.016
dephosphorylationGO:00163112090.016
protein ubiquitinationGO:00165673140.016
cofactor metabolic processGO:0051186870.016
carboxylic acid catabolic processGO:0046395710.016
metal ion homeostasisGO:00550651690.016
divalent inorganic cation transportGO:00725111580.016
regulation of purine nucleotide catabolic processGO:00331212050.016
regulation of body fluid levelsGO:0050878990.016
spermatid developmentGO:000728640.016
cardiovascular system developmentGO:00723582620.016
organic acid catabolic processGO:0016054710.016
negative regulation of hydrolase activityGO:00513461820.016
blood coagulationGO:0007596760.016
actin filament based movementGO:0030048170.016
cell substrate adhesionGO:00315891320.016
vasculature developmentGO:00019441810.016
proteasomal protein catabolic processGO:00104981760.016
regulation of gtp catabolic processGO:00331241800.015
cation homeostasisGO:00550801890.015
regulation of ras protein signal transductionGO:00465781550.015
organophosphate biosynthetic processGO:00904071630.015
anatomical structure formation involved in morphogenesisGO:00486462840.015
protein localization to nucleusGO:00345041360.015
negative regulation of organelle organizationGO:00106391260.015
oocyte differentiationGO:000999420.015
protein targetingGO:00066051870.015
motor neuron axon guidanceGO:000804520.015
oocyte developmentGO:004859910.015
positive regulation of developmental processGO:00510943140.015
behaviorGO:00076101120.015
circulatory system developmentGO:00723592620.015
cell type specific apoptotic processGO:00972851250.015
cellular metal ion homeostasisGO:00068751460.015
organelle assemblyGO:00709251760.015
negative regulation of platelet aggregationGO:009033130.015
calcium ion transportGO:00068161470.015
negative regulation of catabolic processGO:00098951040.015
nucleocytoplasmic transportGO:00069131760.015
regulation of growthGO:00400081650.015
reactive oxygen species metabolic processGO:0072593750.015
cellular divalent inorganic cation homeostasisGO:00725031280.015
cellular cation homeostasisGO:00300031630.015
regulation of transporter activityGO:0032409820.015
regulation of mitotic cell cycleGO:00073461890.015
growthGO:00400072020.014
negative regulation of secretion by cellGO:1903531520.014
positive regulation of lipid metabolic processGO:0045834500.014
establishment of protein localization to organelleGO:00725941720.014
positive regulation of cell proliferationGO:00082843010.014
positive regulation of cell migrationGO:00303351720.014
regulation of actin filament based processGO:00329701410.014
cell cycle phase transitionGO:00447701730.014
rhythmic behaviorGO:000762220.014
regulation of cell growthGO:00015581350.014
cellular ion homeostasisGO:00068731680.014
positive regulation of locomotionGO:00400171860.014
regulation of vesicle mediated transportGO:00606271300.014
positive regulation of cell adhesionGO:0045785840.014
regulation of apoptotic signaling pathwayGO:20012331750.014
negative regulation of locomotionGO:00400131180.014
regulation of cell morphogenesisGO:00226041530.014
morphogenesis of embryonic epitheliumGO:001633140.014
embryonic epithelial tube formationGO:000183840.014
hemostasisGO:0007599760.014
tripartite regional subdivisionGO:000735120.014
carboxylic acid biosynthetic processGO:0046394970.014
microtubule based processGO:00070172100.014
positive regulation of cellular component biogenesisGO:00440891580.014
positive regulation of ras gtpase activityGO:00323201170.014
compound eye developmentGO:004874910.014
negative regulation of cell motilityGO:20001461040.014
regulation of platelet aggregationGO:009033040.014
cell growthGO:00160491600.014
ubiquitin dependent protein catabolic processGO:00065112060.014
regulation of carbohydrate metabolic processGO:0006109540.014
negative regulation of cell cycleGO:00457861930.014
cell divisionGO:00513011680.014
negative regulation of apoptotic processGO:00430663160.014
circulatory system processGO:00030131130.014
morphogenesis of a polarized epitheliumGO:000173830.014
regulation of protein complex assemblyGO:00432541470.014
modification dependent macromolecule catabolic processGO:00436322120.014
negative regulation of protein phosphorylationGO:00019331400.014
regulation of intracellular protein transportGO:00331571230.014
intrinsic apoptotic signaling pathwayGO:00971931270.014
actin mediated cell contractionGO:0070252120.013
nuclear transportGO:00511691790.013
regulation of neural precursor cell proliferationGO:200017740.013
regulation of cell cell adhesionGO:0022407570.013
modification dependent protein catabolic processGO:00199412090.013
regulation of immune responseGO:00507762010.013
cellular chemical homeostasisGO:00550821800.013
monosaccharide metabolic processGO:0005996740.013
negative regulation of protein transportGO:0051224750.013
regulation of sequence specific dna binding transcription factor activityGO:00510902110.013
purine nucleoside monophosphate metabolic processGO:00091261860.013
purine ribonucleoside monophosphate metabolic processGO:00091671860.013
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.013
positive regulation of synaptic transmissionGO:005080640.013
endocytosisGO:00068971590.013
negative regulation of secretionGO:0051048580.013
circadian behaviorGO:004851220.013
signal transduction by phosphorylationGO:00230142970.013
cell part morphogenesisGO:00329901370.013
regulation of ras gtpase activityGO:00323181280.013
negative regulation of transferase activityGO:00513481240.013
nucleoside monophosphate metabolic processGO:00091231910.013
organic acid biosynthetic processGO:0016053970.013
negative regulation of blood pressureGO:004577630.013
neurological system processGO:00508771630.013
response to bacteriumGO:00096171440.013
negative regulation of cytokine productionGO:0001818820.013
regulation of transmembrane transporter activityGO:0022898740.013
cell projection morphogenesisGO:00488581290.013
regulation of cytoplasmic transportGO:19036491490.013
protein homooligomerizationGO:00512601000.013
regulation of response to woundingGO:19030341010.013
regulation of cellular carbohydrate metabolic processGO:0010675470.013
cellular response to hormone stimulusGO:00328701250.013
activation of immune responseGO:00022531140.013
positive regulation of protein transportGO:00512221350.013
regulation of cell activationGO:00508651250.013
response to metal ionGO:0010038840.013
positive regulation of cellular component movementGO:00512721810.013
plasma membrane organizationGO:00070091150.013
protein autophosphorylationGO:00467771230.013
regulation of synaptic plasticityGO:004816730.013
response to fungusGO:000962040.013
glycoprotein biosynthetic processGO:0009101910.013
cell morphogenesis involved in differentiationGO:00009041440.013
chromatin modificationGO:00165682980.012
cardiac muscle contractionGO:0060048340.012
ribonucleoside monophosphate metabolic processGO:00091611870.012
cellular response to growth factor stimulusGO:00713631970.012
response to tumor necrosis factorGO:0034612760.012
microtubule cytoskeleton organizationGO:00002261760.012
posttranscriptional regulation of gene expressionGO:00106082130.012
covalent chromatin modificationGO:00165692540.012
regulation of protein catabolic processGO:00421761550.012
acylglycerol metabolic processGO:0006639270.012
hemopoiesisGO:00300971800.012
positive regulation of protein serine threonine kinase activityGO:00719021190.012
response to activityGO:001482300.012
negative regulation of immune system processGO:00026831360.012
regulation of ion transmembrane transporter activityGO:0032412720.012
regulation of reactive oxygen species biosynthetic processGO:190342630.012
triglyceride metabolic processGO:0006641230.012
dna repairGO:00062811980.012
syncytium formation by plasma membrane fusionGO:000076820.012
positive regulation of cell cycleGO:00457871400.012
negative regulation of homotypic cell cell adhesionGO:003411130.012
regulation of bindingGO:00510981110.012
reactive nitrogen species metabolic processGO:200105730.012
cellular response to tumor necrosis factorGO:0071356630.012
reactive oxygen species biosynthetic processGO:190340940.012
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.012
reproductive processGO:00224141060.012
cellular response to abiotic stimulusGO:00712141170.012
positive regulation of reactive oxygen species biosynthetic processGO:190342820.012
regulation of protein maturationGO:19033171500.012
cation transmembrane transportGO:00986552380.012
protein localization to plasma membraneGO:0072659930.012
response to drugGO:0042493810.012
organic hydroxy compound biosynthetic processGO:1901617710.012
negative regulation of cellular component movementGO:00512711060.012
cytokine secretionGO:0050663640.012
cerebellum developmentGO:002154920.012
regulation of endopeptidase activityGO:00525481700.012
positive regulation of reactive oxygen species metabolic processGO:2000379240.012
rna processingGO:00063962550.012
organic anion transportGO:00157111030.012
g protein coupled receptor signaling pathwayGO:00071862070.012
cell projection assemblyGO:00300311260.012
peptidyl lysine modificationGO:00182051440.012
receptor metabolic processGO:0043112810.011
extrinsic apoptotic signaling pathwayGO:00971911190.011
establishment of protein localization to membraneGO:00901501210.011
coenzyme metabolic processGO:0006732650.011
epithelium developmentGO:00604292270.011
tissue regenerationGO:004224630.011
organ formationGO:004864530.011
positive regulation of secretionGO:00510471160.011
cellular calcium ion homeostasisGO:00068741170.011
response to growth factorGO:00708482050.011
positive regulation of cell differentiationGO:00455972110.011
phospholipid metabolic processGO:0006644990.011
homotypic cell cell adhesionGO:0034109470.011
metencephalon developmentGO:002203720.011
mitotic cell cycle phase transitionGO:00447721620.011
tube developmentGO:00352951250.011
positive regulation of cell motilityGO:20001471770.011
negative regulation of growthGO:0045926970.011
neural tube formationGO:000184130.011
organelle fissionGO:00482851490.011
regulation of ion transmembrane transportGO:00347651320.011
developmental programmed cell deathGO:001062330.011
atp metabolic processGO:00460341760.011
regulation of protein processingGO:00706131500.011
inner ear morphogenesisGO:004247240.011
ameboidal type cell migrationGO:00016671350.011
regulation of peptidase activityGO:00525471800.011
negative regulation of cell migrationGO:00303361020.011
actin filament organizationGO:00070151280.011
fatty acid catabolic processGO:0009062290.011
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.011
mitochondrion organizationGO:00070051560.011
meiotic chromosome segregationGO:004513240.011
response to virusGO:00096151260.011
regulation of meiotic cell cycleGO:005144540.011
protein polymerizationGO:0051258710.011
ossificationGO:00015031210.011
osteoblast differentiationGO:0001649920.011
interspecies interaction between organismsGO:00444191560.011
stress activated protein kinase signaling cascadeGO:0031098940.010
negative regulation of cellular catabolic processGO:0031330830.010
tube closureGO:006060630.010
neurotransmitter secretionGO:000726940.010
regulation of defense responseGO:00313471540.010
cell fate determinationGO:000170930.010
cellular response to organic cyclic compoundGO:00714071270.010
response to axon injuryGO:004867810.010
heart developmentGO:0007507950.010
erk1 and erk2 cascadeGO:00703711040.010
purine ribonucleoside monophosphate catabolic processGO:00091691580.010

PLIN4 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:172230.048
disease of metabolismDOID:00146672950.036
muscle tissue diseaseDOID:661130.030
muscular diseaseDOID:00800001140.030
inherited metabolic disorderDOID:6552420.027
myopathyDOID:4231040.024
cardiovascular system diseaseDOID:12871060.024
sensory system diseaseDOID:00501552030.020
nervous system diseaseDOID:8634310.020
heart diseaseDOID:114680.017
eye and adnexa diseaseDOID:14921500.016
eye diseaseDOID:56141490.016
central nervous system diseaseDOID:3311860.015
disease of cellular proliferationDOID:145661740.015
cancerDOID:1621670.014
organ system cancerDOID:00506861640.013
neurodegenerative diseaseDOID:12891020.011