Homo sapiens

0 known processes

ZFX

zinc finger protein, X-linked

(Aliases: ZNF926)

ZFX biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
morphogenesis of embryonic epitheliumGO:001633140.723
determination of adult lifespanGO:000834020.638
histone h3 k27 demethylationGO:007155730.626
neural tube formationGO:000184130.551
primary neural tube formationGO:001402030.477
multicellular organismal agingGO:001025930.455
anterior posterior axis specificationGO:000994820.424
somitogenesisGO:000175620.408
positive regulation of developmental processGO:00510943140.398
histone demethylationGO:0016577150.392
embryonic epithelial tube formationGO:000183840.380
neural tube closureGO:000184330.342
growthGO:00400072020.339
Human
covalent chromatin modificationGO:00165692540.317
digestive tract developmentGO:0048565750.261
regulation of growthGO:00400081650.256
Human
organ morphogenesisGO:00098871470.241
wnt signaling pathwayGO:00160551560.224
digestive tract morphogenesisGO:0048546560.222
canonical wnt signaling pathwayGO:00600701160.217
system processGO:00030083490.216
demethylationGO:0070988370.205
segmentationGO:003528240.198
chromatin organizationGO:00063253510.196
mesodermal cell differentiationGO:0048333100.186
nervous system developmentGO:00073992930.176
post embryonic developmentGO:000979120.167
tube developmentGO:00352951250.160
respiratory gaseous exchangeGO:000758530.155
regulation of multicellular organism growthGO:004001480.153
formation of primary germ layerGO:0001704420.150
tube closureGO:006060630.146
embryonic organ morphogenesisGO:0048562240.144
embryonic morphogenesisGO:0048598850.135
anatomical structure formation involved in morphogenesisGO:00486462840.135
protein methylationGO:0006479740.127
histone modificationGO:00165702510.114
heart morphogenesisGO:0003007480.113
protein demethylationGO:0006482170.102
protein dealkylationGO:0008214170.100
epithelium developmentGO:00604292270.095
heart developmentGO:0007507950.090
respiratory system processGO:000301630.090
positive regulation of growthGO:0045927580.088
Human
extrinsic apoptotic signaling pathwayGO:00971911190.084
chromatin modificationGO:00165682980.084
female gamete generationGO:000729220.084
macromolecule methylationGO:0043414970.082
histone lysine demethylationGO:0070076140.082
cardiovascular system developmentGO:00723582620.080
purine nucleotide catabolic processGO:00061954050.080
positive regulation of developmental growthGO:0048639160.079
cellular amino acid metabolic processGO:00065201160.078
purine ribonucleotide catabolic processGO:00091544040.078
morphogenesis of an epitheliumGO:0002009600.075
purine ribonucleoside catabolic processGO:00461303980.073
purine ribonucleoside metabolic processGO:00461284370.073
cell developmentGO:00484683280.072
ribonucleoside catabolic processGO:00424544060.070
circulatory system developmentGO:00723592620.069
tube morphogenesisGO:0035239950.068
cellular ketone metabolic processGO:0042180800.066
cell growthGO:00160491600.066
Human
nucleoside phosphate catabolic processGO:19012924120.065
neuromuscular junction developmentGO:000752830.065
cellular amine metabolic processGO:0044106410.062
organophosphate catabolic processGO:00464344300.062
ras protein signal transductionGO:0007265730.061
ribonucleoside triphosphate metabolic processGO:00091994120.061
embryo developmentGO:00097901230.060
developmental growthGO:0048589480.058
cell morphogenesisGO:00009022960.058
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.058
regulation of cellular amine metabolic processGO:0033238110.057
glycosyl compound catabolic processGO:19016584130.057
regulation of defense responseGO:00313471540.056
negative regulation of catalytic activityGO:00430863350.056
methylationGO:00322591060.053
nucleoside triphosphate metabolic processGO:00091414220.050
response to abiotic stimulusGO:00096283360.049
nucleoside triphosphate catabolic processGO:00091433940.048
cellular response to endogenous stimulusGO:00714953360.048
regulation of cell differentiationGO:00455953930.047
purine nucleoside triphosphate metabolic processGO:00091444120.047
memoryGO:000761330.047
negative regulation of developmental processGO:00510932470.047
peptidyl serine modificationGO:00182091060.047
cytokine productionGO:00018162470.046
regulation of nucleotide metabolic processGO:00061402690.046
regionalizationGO:0003002290.046
peptidyl serine phosphorylationGO:00181051010.046
hindbrain developmentGO:003090230.045
regulation of response to external stimulusGO:00321012220.044
purine nucleoside catabolic processGO:00061523980.044
ribonucleotide catabolic processGO:00092614050.044
positive regulation of cellular amino acid metabolic processGO:004576430.043
nucleoside catabolic processGO:00091644080.042
positive regulation of cellular amine metabolic processGO:003324070.042
regulation of cellular ketone metabolic processGO:0010565500.042
response to other organismGO:00517072610.042
negative regulation of protein metabolic processGO:00512483910.042
ribonucleoside triphosphate catabolic processGO:00092033910.041
positive regulation of phosphorylationGO:00423273940.041
response to biotic stimulusGO:00096072760.041
mitotic cell cycleGO:00002783260.040
regulation of developmental growthGO:0048638300.040
skeletal system developmentGO:0001501790.040
protein processingGO:00164852260.040
regulation of endopeptidase activityGO:00525481700.040
defense responseGO:00069523150.040
tissue morphogenesisGO:0048729960.040
metencephalon developmentGO:002203720.039
protein alkylationGO:0008213740.039
regulation of cellular amino acid metabolic processGO:000652160.038
agingGO:0007568660.038
locomotory behaviorGO:000762610.038
purine ribonucleoside triphosphate catabolic processGO:00092073910.038
negative regulation of cell proliferationGO:00082852280.037
regulation of cellular component biogenesisGO:00440872810.037
regulation of anatomical structure morphogenesisGO:00226032860.037
purine containing compound catabolic processGO:00725234110.037
negative regulation of cellular protein metabolic processGO:00322693530.037
cell projection organizationGO:00300302520.037
cellular macromolecule catabolic processGO:00442653800.037
regulation of cell cycleGO:00517263930.036
mesoderm developmentGO:0007498140.036
immune responseGO:00069553070.036
negative regulation of programmed cell deathGO:00430693210.036
embryonic organ developmentGO:0048568360.036
neural tube developmentGO:002191590.036
apoptotic signaling pathwayGO:00971902680.035
positive regulation of multicellular organism growthGO:004001860.035
response to external biotic stimulusGO:00432072610.035
regulation of peptidase activityGO:00525471800.035
histone acetylationGO:0016573930.033
positive regulation of transportGO:00510503360.033
somite developmentGO:006105370.033
spermatid developmentGO:000728640.033
reproductive processGO:00224141060.033
positive regulation of proteolysisGO:00458621420.033
positive regulation of programmed cell deathGO:00430682490.033
pattern specification processGO:0007389430.032
oogenesisGO:004847720.032
guanosine containing compound catabolic processGO:19010692390.032
negative regulation of cellular amine metabolic processGO:003323930.032
single organism reproductive processGO:0044702980.031
response to nitrogen compoundGO:19016981840.031
regulation of cysteine type endopeptidase activityGO:20001161270.031
response to oxygen containing compoundGO:19017003690.031
cellular component morphogenesisGO:00329893140.030
hippocampus developmentGO:002176610.030
purine nucleoside monophosphate metabolic processGO:00091261860.029
nucleotide catabolic processGO:00091664080.029
nucleus localizationGO:005164710.028
forelimb morphogenesisGO:003513640.028
regulation of cell morphogenesisGO:00226041530.028
peptidyl tyrosine phosphorylationGO:00181081700.028
positive regulation of cellular component organizationGO:00511303760.028
rna interferenceGO:001624640.028
mesoderm morphogenesisGO:0048332110.028
negative regulation of proteolysisGO:00458611320.028
internal peptidyl lysine acetylationGO:0018393970.028
cell cycle phase transitionGO:00447701730.027
negative regulation of cell deathGO:00605483450.027
response to lipidGO:00339932060.027
small gtpase mediated signal transductionGO:0007264780.027
chordate embryonic developmentGO:0043009340.026
regulation of transferase activityGO:00513383550.026
negative regulation of immune system processGO:00026831360.026
gtp catabolic processGO:00061842370.026
oocyte developmentGO:004859910.025
regulation of purine nucleotide metabolic processGO:19005422640.025
hematopoietic or lymphoid organ developmentGO:00485341860.025
positive regulation of peptidase activityGO:0010952880.025
enzyme linked receptor protein signaling pathwayGO:00071673030.025
vesicle mediated transportGO:00161923710.025
mesoderm formationGO:0001707100.025
regulation of proteolysisGO:00301622930.025
endocytosisGO:00068971590.025
protein catabolic processGO:00301633250.025
response to tumor necrosis factorGO:0034612760.024
positive regulation of protein kinase activityGO:00458601900.024
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280690.024
negative regulation of cell growthGO:0030308830.024
response to growth factorGO:00708482050.024
secretion by cellGO:00329402260.024
positive regulation of purine nucleotide metabolic processGO:19005442270.023
limbic system developmentGO:002176130.023
regulation of nucleoside metabolic processGO:00091182090.023
developmental process involved in reproductionGO:0003006660.023
positive regulation of cellular catabolic processGO:00313312840.023
cellular response to cytokine stimulusGO:00713451810.023
purine nucleoside triphosphate catabolic processGO:00091463920.023
negative regulation of cellular amino acid metabolic processGO:004576320.023
chemical homeostasisGO:00488783060.023
neurological system processGO:00508771630.023
negative regulation of cysteine type endopeptidase activityGO:2000117480.023
positive regulation of wnt signaling pathwayGO:0030177540.023
positive regulation of catabolic processGO:00098963100.023
cellular chemical homeostasisGO:00550821800.022
regulation of kinase activityGO:00435493140.022
spermatid differentiationGO:004851540.022
positive regulation of transferase activityGO:00513472270.022
head developmentGO:00603221080.022
regulation of leukocyte activationGO:00026941150.022
epithelial cell differentiationGO:00308551410.022
protein ubiquitinationGO:00165673140.022
protein homooligomerizationGO:00512601000.022
regulation of cell growthGO:00015581350.022
Human
protein modification by small protein conjugationGO:00324463420.022
response to radiationGO:00093141510.022
cellular protein catabolic processGO:00442572610.022
positive regulation of immune system processGO:00026842830.021
posttranscriptional regulation of gene expressionGO:00106082130.021
positive regulation of cell proliferationGO:00082843010.021
amine metabolic processGO:0009308440.021
positive regulation of apoptotic processGO:00430652460.021
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.021
regulation of immune responseGO:00507762010.021
neurogenesisGO:00220081690.021
rna processingGO:00063962550.021
negative regulation of protein maturationGO:19033181420.021
response to organic cyclic compoundGO:00140702040.021
actin filament based processGO:00300292240.021
lipid metabolic processGO:00066293810.021
rhythmic behaviorGO:000762220.021
negative regulation of peptidase activityGO:0010466910.021
response to organonitrogen compoundGO:00102431560.021
peptidyl tyrosine modificationGO:00182121700.021
multicellular organism growthGO:003526480.021
embryo development ending in birth or egg hatchingGO:0009792340.021
positive regulation of nucleoside metabolic processGO:00459791860.021
blastoderm segmentationGO:000735020.021
negative regulation of apoptotic processGO:00430663160.020
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.020
positive regulation of hydrolase activityGO:00513453310.020
cell morphogenesis involved in differentiationGO:00009041440.020
carbohydrate derivative biosynthetic processGO:19011372070.020
modification dependent protein catabolic processGO:00199412090.020
endosomal transportGO:00161971290.020
negative regulation of hydrolase activityGO:00513461820.020
positive regulation of cell deathGO:00109422630.020
ribonucleoside monophosphate metabolic processGO:00091611870.020
negative regulation of protein processingGO:00109551420.020
cellular response to dna damage stimulusGO:00069743790.020
neuron differentiationGO:00301821380.020
nuclear migrationGO:000709710.020
response to cytokineGO:00340972320.019
protein acetylationGO:00064731160.019
protein acylationGO:00435431380.019
nucleoside monophosphate metabolic processGO:00091231910.019
establishment of nucleus localizationGO:004002310.019
neuron developmentGO:00486661130.019
gtp metabolic processGO:00460392390.019
cytoplasmic transportGO:00164823790.019
purine ribonucleoside monophosphate metabolic processGO:00091671860.019
positive regulation of protein phosphorylationGO:00019343130.019
regulation of reactive oxygen species biosynthetic processGO:190342630.019
purine ribonucleoside triphosphate metabolic processGO:00092054110.018
positive regulation of locomotionGO:00400171860.018
trophectodermal cell differentiationGO:000182930.018
regulation of cell developmentGO:00602841610.018
positive regulation of mapk cascadeGO:00434101900.018
cellular response to oxygen containing compoundGO:19017012760.018
regulation of cellular component movementGO:00512703340.018
internal protein amino acid acetylationGO:00064751010.018
rho protein signal transductionGO:0007266260.018
regulation of ras protein signal transductionGO:00465781550.018
regulation of locomotionGO:00400123290.018
atp catabolic processGO:00062001570.018
positive regulation of cell motilityGO:20001471770.018
ubiquitin dependent protein catabolic processGO:00065112060.018
interspecies interaction between organismsGO:00444191560.018
Human
response to virusGO:00096151260.018
regulation of protein maturationGO:19033171500.017
cellular macromolecular complex assemblyGO:00346223240.017
glycoprotein metabolic processGO:00091001100.017
reproductive structure developmentGO:0048608550.017
negative regulation of defense responseGO:0031348470.017
regulation of cell activationGO:00508651250.017
cellular response to growth factor stimulusGO:00713631970.017
regulation of establishment of protein localizationGO:00702012420.017
proteolysis involved in cellular protein catabolic processGO:00516032440.017
innate immune responseGO:00450871780.017
negative regulation of cell differentiationGO:00455961710.017
regulation of nucleotide catabolic processGO:00308112050.017
atp metabolic processGO:00460341760.017
regulation of protein kinase activityGO:00458592890.017
neurotransmitter secretionGO:000726940.017
gastrulation with mouth forming secondGO:000170210.017
negative regulation of intracellular signal transductionGO:19025321830.017
positive regulation of canonical wnt signaling pathwayGO:0090263330.017
mitotic cell cycle phase transitionGO:00447721620.017
reproductive system developmentGO:0061458560.017
negative regulation of cellular component organizationGO:00511292350.017
translationGO:00064121320.017
regulation of wnt signaling pathwayGO:00301111230.017
cellular response to organonitrogen compoundGO:00714171240.016
positive regulation of organelle organizationGO:00106381950.016
negative regulation of phosphate metabolic processGO:00459362670.016
regulation of cell motilityGO:20001452990.016
neuron projection developmentGO:00311751060.016
negative regulation of apoptotic signaling pathwayGO:2001234970.016
hemopoiesisGO:00300971800.016
regulation of translationGO:0006417890.016
regulation of cellular component sizeGO:0032535820.016
blastocyst formationGO:000182530.016
regulation of cell migrationGO:00303342890.016
glycosylationGO:0070085710.016
sex differentiationGO:0007548450.016
cellular protein complex assemblyGO:00436231880.016
biological adhesionGO:00226103310.016
maintenance of locationGO:00512351120.016
chromosome segregationGO:00070591140.016
protein stabilizationGO:0050821640.016
regulation of cellular response to stressGO:00801352440.016
dephosphorylationGO:00163112090.016
response to woundingGO:00096111680.016
regulation of cytoplasmic transportGO:19036491490.016
long term memoryGO:000761620.016
peptidyl lysine acetylationGO:00183941010.016
peripheral nervous system developmentGO:000742220.016
negative regulation of endopeptidase activityGO:0010951840.016
mitotic cell cycle processGO:19030472860.016
negative regulation of growthGO:0045926970.016
actin cytoskeleton organizationGO:00300362070.015
lymphocyte activationGO:00466491330.015
translational initiationGO:0006413480.015
regulation of neural precursor cell proliferationGO:200017740.015
negative regulation of multicellular organismal processGO:00512413170.015
negative regulation of synaptic transmissionGO:005080520.015
reactive oxygen species biosynthetic processGO:190340940.015
response to hypoxiaGO:0001666960.015
developmental growth involved in morphogenesisGO:0060560230.015
response to hormoneGO:00097251750.015
embryonic placenta developmentGO:000189210.015
positive regulation of cytokine productionGO:00018191670.015
regulation of secretion by cellGO:19035301770.015
guanosine containing compound metabolic processGO:19010682440.015
response to bacteriumGO:00096171440.015
modification dependent macromolecule catabolic processGO:00436322120.015
immune system developmentGO:00025201950.015
regulation of cell cycle processGO:00105642660.015
regulation of extrinsic apoptotic signaling pathwayGO:2001236850.015
viral processGO:00160321460.015
Human
associative learningGO:000830610.015
generation of neuronsGO:00486991520.015
response to transforming growth factor betaGO:0071559940.015
regulation of sequence specific dna binding transcription factor activityGO:00510902110.014
regulation of mitotic cell cycleGO:00073461890.014
tube formationGO:0035148100.014
single organism carbohydrate metabolic processGO:00447231930.014
protein deubiquitinationGO:0016579790.014
intracellular protein transportGO:00068862700.014
rna splicingGO:00083801310.014
leukocyte activationGO:00453211640.014
positive regulation of reactive oxygen species metabolic processGO:2000379240.014
regulation of i kappab kinase nf kappab signalingGO:00431221620.014
regulation of epithelial cell proliferationGO:00506781130.014
regulation of lymphocyte activationGO:00512491030.014
endomembrane system organizationGO:00102561960.014
protein localization to organelleGO:00333652800.014
behaviorGO:00076101120.014
matingGO:000761810.014
behavioral response to ethanolGO:004814920.014
embryonic viscerocranium morphogenesisGO:004870310.014
glycoprotein biosynthetic processGO:0009101910.014
regulation of canonical wnt signaling pathwayGO:0060828880.014
positive regulation of dendrite morphogenesisGO:005077530.014
regulation of innate immune responseGO:0045088970.014
positive regulation of cellular component movementGO:00512721810.014
regulation of protein stabilityGO:0031647870.014
nucleoside monophosphate catabolic processGO:00091251590.014
purine nucleoside monophosphate catabolic processGO:00091281580.014
positive regulation of cell sizeGO:004579330.014
positive regulation of nucleotide catabolic processGO:00308131850.014
inner ear morphogenesisGO:004247240.013
protein targetingGO:00066051870.013
neuroblast proliferationGO:000740540.013
embryonic camera type eye morphogenesisGO:004859620.013
cell adhesionGO:00071553250.013
protein oligomerizationGO:00512591730.013
regulation of apoptotic signaling pathwayGO:20012331750.013
regulation of growth rateGO:004000910.013
cellular response to decreased oxygen levelsGO:0036294510.013
positive regulation of cysteine type endopeptidase activityGO:2001056790.013
macromolecule glycosylationGO:0043413630.013
regulation of intracellular protein transportGO:00331571230.013
metal ion homeostasisGO:00550651690.013
cell part morphogenesisGO:00329901370.013
regulation of intracellular transportGO:00323861950.013
blastocyst developmentGO:000182430.013
cellular response to abiotic stimulusGO:00712141170.013
negative regulation of cell cycleGO:00457861930.013
metal ion transportGO:00300012720.013
regulation of nucleocytoplasmic transportGO:0046822980.013
cellular response to hormone stimulusGO:00328701250.013
ribonucleoside monophosphate catabolic processGO:00091581580.013
cell activationGO:00017752130.013
lymphocyte homeostasisGO:000226040.013
stem cell differentiationGO:0048863930.013
stress activated mapk cascadeGO:0051403930.013
cell cell signalingGO:00072671550.013
ossificationGO:00015031210.013
regulation of meiotic cell cycleGO:005144540.013
nuclear transportGO:00511691790.013
positive regulation of nucleotide metabolic processGO:00459812300.013
wound healingGO:00420601150.013
regulation of secretionGO:00510461940.013
oocyte differentiationGO:000999420.013
cellular homeostasisGO:00197251960.013
regenerationGO:003109940.013
tor signalingGO:0031929390.012
organelle fissionGO:00482851490.012
negative regulation of phosphorus metabolic processGO:00105632670.012
negative regulation of protein modification processGO:00314002000.012
positive regulation of cell growthGO:0030307480.012
Human
positive regulation of gtp catabolic processGO:00331261660.012
positive regulation of kinase activityGO:00336742040.012
regulation of anatomical structure sizeGO:00900661010.012
syncytium formation by plasma membrane fusionGO:000076820.012
regulation of chromatin organizationGO:1902275560.012
ion homeostasisGO:00508012300.012
regulation of small gtpase mediated signal transductionGO:00510561560.012
regulation of protein transportGO:00512232130.012
taxisGO:00423301570.012
nitrogen compound transportGO:00717051910.012
signal transduction by phosphorylationGO:00230142970.012
rna splicing via transesterification reactionsGO:0000375900.012
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.012
protein glycosylationGO:0006486620.012
mitotic nuclear divisionGO:00070671190.012
central nervous system developmentGO:00074171230.012
response to ionizing radiationGO:0010212650.012
regulation of response to woundingGO:19030341010.012
symbiosis encompassing mutualism through parasitismGO:00444031560.012
Human
positive regulation of endopeptidase activityGO:0010950840.012
regulation of cytoskeleton organizationGO:00514931770.012
regulation of cell cycle phase transitionGO:19019871260.012
protein maturationGO:00516042330.012
organonitrogen compound biosynthetic processGO:19015662000.012
embryonic eye morphogenesisGO:004804820.012
regulation of vesicle mediated transportGO:00606271300.012
myosin filament assemblyGO:003103420.011
negative regulation of phosphorylationGO:00423261740.011
regulation of chromosome organizationGO:00330441030.011
peptidyl lysine modificationGO:00182051440.011
protein autophosphorylationGO:00467771230.011
i kappab kinase nf kappab signalingGO:00072491660.011
negative regulation of axon extensionGO:003051720.011
regulation of meiosisGO:004002030.011
ribonucleoprotein complex biogenesisGO:00226131160.011
regulation of reactive oxygen species metabolic processGO:2000377410.011
transmembrane transportGO:00550853990.011
mapk cascadeGO:00001652880.011
anterior posterior axis specification embryoGO:000859520.011
cation transportGO:00068123310.011
proteasomal protein catabolic processGO:00104981760.011
embryonic forelimb morphogenesisGO:003511540.011
regulation of protein complex assemblyGO:00432541470.011
positive regulation of gtpase activityGO:00435471660.011
regulation of neurotransmitter secretionGO:004692830.011
sister chromatid segregationGO:0000819540.011
negative regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043154460.011
positive regulation of purine nucleotide catabolic processGO:00331231850.011
positive regulation of cell migrationGO:00303351720.011
myoblast fusionGO:000752010.011
regulation of protein localizationGO:00328802960.011
skeletal muscle tissue growthGO:004863020.011
negative regulation of mitotic cell cycleGO:00459301020.011
cellular response to external stimulusGO:00714961110.011
bmp signaling pathwayGO:0030509490.011
reactive nitrogen species metabolic processGO:200105730.011
cell migration involved in gastrulationGO:004207410.011
regulation of stress activated protein kinase signaling cascadeGO:0070302850.011
regulation of mitotic cell cycle phase transitionGO:19019901180.011
regulation of purine nucleotide catabolic processGO:00331212050.011
reactive oxygen species metabolic processGO:0072593750.010
convergent extensionGO:006002610.010
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.010
angiogenesisGO:00015251470.010
regulation of cytokine productionGO:00018172320.010
positive regulation of immune responseGO:00507781590.010

ZFX disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
sensory system diseaseDOID:00501552030.054
nervous system diseaseDOID:8634310.054
eye diseaseDOID:56141490.041
eye and adnexa diseaseDOID:14921500.041
disease of cellular proliferationDOID:145661740.033
organ system cancerDOID:00506861640.023
cancerDOID:1621670.023
musculoskeletal system diseaseDOID:172230.018
central nervous system diseaseDOID:3311860.018
retinal degenerationDOID:8466890.012
retinal diseaseDOID:56791180.012