Homo sapiens

110 known processes

TOPORS

topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase

(Aliases: TP53BPL,P53BP3,RP31,LUN)

TOPORS biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
protein modification by small protein conjugationGO:00324463420.964
protein ubiquitinationGO:00165673140.787
ubiquitin dependent protein catabolic processGO:00065112060.690
cellular protein catabolic processGO:00442572610.573
proteolysis involved in cellular protein catabolic processGO:00516032440.550
modification dependent macromolecule catabolic processGO:00436322120.513
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.421
protein polyubiquitinationGO:00002091100.408
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.389
modification dependent protein catabolic processGO:00199412090.334
cellular response to dna damage stimulusGO:00069743790.284
chromatin modificationGO:00165682980.262
proteasomal protein catabolic processGO:00104981760.261
i kappab kinase nf kappab signalingGO:00072491660.243
regulation of cell cycleGO:00517263930.237
Fly
cellular amino acid metabolic processGO:00065201160.200
positive regulation of cell deathGO:00109422630.181
cellular macromolecule catabolic processGO:00442653800.180
negative regulation of cell deathGO:00605483450.171
protein catabolic processGO:00301633250.158
negative regulation of apoptotic processGO:00430663160.153
negative regulation of catalytic activityGO:00430863350.140
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.136
amine metabolic processGO:0009308440.131
positive regulation of programmed cell deathGO:00430682490.125
histone ubiquitinationGO:0016574310.120
regulation of cellular response to stressGO:00801352440.118
androgen receptor signaling pathwayGO:0030521340.114
intracellular steroid hormone receptor signaling pathwayGO:0030518610.104
regulation of i kappab kinase nf kappab signalingGO:00431221620.101
regulation of apoptotic signaling pathwayGO:20012331750.092
protein processingGO:00164852260.089
regulation of cellular ketone metabolic processGO:0010565500.088
protein glycosylationGO:0006486620.086
regulation of proteolysisGO:00301622930.086
neural tube formationGO:000184130.085
regulation of intrinsic apoptotic signaling pathwayGO:2001242720.084
morphogenesis of embryonic epitheliumGO:001633140.081
intracellular receptor signaling pathwayGO:00305221040.078
embryonic epithelial tube formationGO:000183840.077
negative regulation of protein metabolic processGO:00512483910.072
regulation of proteolysis involved in cellular protein catabolic processGO:1903050910.068
macromolecule methylationGO:0043414970.068
regulation of cellular component biogenesisGO:00440872810.067
nervous system developmentGO:00073992930.067
negative regulation of programmed cell deathGO:00430693210.065
negative regulation of protein maturationGO:19033181420.064
protein maturationGO:00516042330.064
regulation of cellular amine metabolic processGO:0033238110.062
dna repairGO:00062811980.061
extrinsic apoptotic signaling pathwayGO:00971911190.061
interspecies interaction between organismsGO:00444191560.060
regulation of anatomical structure morphogenesisGO:00226032860.059
protein autoubiquitinationGO:0051865370.059
post embryonic developmentGO:000979120.059
cellular ketone metabolic processGO:0042180800.058
mitotic cell cycle phase transitionGO:00447721620.055
Fly
negative regulation of proteolysisGO:00458611320.054
carbohydrate derivative biosynthetic processGO:19011372070.054
regulation of kinase activityGO:00435493140.054
vesicle mediated transportGO:00161923710.053
regulation of endopeptidase activityGO:00525481700.053
regulation of protein processingGO:00706131500.052
apoptotic signaling pathwayGO:00971902680.051
response to radiationGO:00093141510.050
regulation of chromosome organizationGO:00330441030.049
covalent chromatin modificationGO:00165692540.049
system processGO:00030083490.048
regulation of mitotic cell cycleGO:00073461890.048
Fly
positive regulation of apoptotic processGO:00430652460.047
viral processGO:00160321460.046
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434710.045
histone modificationGO:00165702510.045
negative regulation of endopeptidase activityGO:0010951840.045
positive regulation of cellular amino acid metabolic processGO:004576430.044
positive regulation of organelle organizationGO:00106381950.043
response to abiotic stimulusGO:00096283360.043
positive regulation of cellular component organizationGO:00511303760.042
protein oligomerizationGO:00512591730.042
positive regulation of catabolic processGO:00098963100.042
dna templated transcription initiationGO:0006352350.042
negative regulation of cellular protein metabolic processGO:00322693530.041
regulation of cysteine type endopeptidase activityGO:20001161270.041
intrinsic apoptotic signaling pathwayGO:00971931270.040
regulation of response to dna damage stimulusGO:2001020940.040
cellular response to lipidGO:00713961270.039
cellular amine metabolic processGO:0044106410.039
determination of adult lifespanGO:000834020.039
leukocyte apoptotic processGO:0071887310.039
viral release from host cellGO:0019076210.039
carbohydrate metabolic processGO:00059752070.039
positive regulation of wnt signaling pathwayGO:0030177540.039
negative regulation of protein processingGO:00109551420.038
signal transduction by phosphorylationGO:00230142970.038
regulation of sequence specific dna binding transcription factor activityGO:00510902110.037
positive regulation of cellular amine metabolic processGO:003324070.037
negative regulation of cell proliferationGO:00082852280.037
regulation of transcription by chromatin organizationGO:003440110.037
regulation of cell cycle processGO:00105642660.036
Fly
nucleoside monophosphate metabolic processGO:00091231910.036
ribonucleoside triphosphate catabolic processGO:00092033910.036
negative regulation of cellular amine metabolic processGO:003323930.035
protein ubiquitination involved in ubiquitin dependent protein catabolic processGO:0042787370.035
Fly
regulation of viral processGO:00507921030.035
positive regulation of proteolysisGO:00458621420.035
response to lipidGO:00339932060.034
negative regulation of apoptotic signaling pathwayGO:2001234970.034
positive regulation of cell differentiationGO:00455972110.034
negative regulation of cell developmentGO:0010721480.033
multicellular organismal agingGO:001025930.033
negative regulation of transferase activityGO:00513481240.032
positive regulation of apoptotic signaling pathwayGO:2001235700.031
establishment or maintenance of apical basal cell polarityGO:003508820.031
regulation of protein ubiquitinationGO:0031396950.030
cellular response to cytokine stimulusGO:00713451810.030
regulation of intracellular steroid hormone receptor signaling pathwayGO:0033143320.030
regulation of protein catabolic processGO:00421761550.030
regulation of symbiosis encompassing mutualism through parasitismGO:00439031090.029
somitogenesisGO:000175620.029
ribonucleoside monophosphate metabolic processGO:00091611870.027
glycoprotein metabolic processGO:00091001100.027
negative regulation of phosphorylationGO:00423261740.027
regulation of wnt signaling pathwayGO:00301111230.027
circulatory system developmentGO:00723592620.026
wnt signaling pathwayGO:00160551560.026
memoryGO:000761330.026
regulation of response to external stimulusGO:00321012220.025
inflammatory responseGO:0006954790.025
regulation of protein maturationGO:19033171500.025
long term memoryGO:000761620.025
female gamete generationGO:000729220.025
negative regulation of kinase activityGO:00336731060.025
neurogenesisGO:00220081690.024
cellular response to oxygen containing compoundGO:19017012760.024
positive regulation of cellular catabolic processGO:00313312840.024
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.024
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.024
negative regulation of cellular component organizationGO:00511292350.024
positive regulation of developmental processGO:00510943140.024
defense responseGO:00069523150.023
response to organic cyclic compoundGO:00140702040.023
cell projection organizationGO:00300302520.023
regulation of autophagyGO:0010506520.023
regulation of cellular amino acid metabolic processGO:000652160.023
purine ribonucleoside monophosphate metabolic processGO:00091671860.023
positive regulation of transportGO:00510503360.023
canonical wnt signaling pathwayGO:00600701160.022
negative regulation of transportGO:00510511760.022
negative regulation of phosphate metabolic processGO:00459362670.022
histone h3 acetylationGO:0043966450.022
actin cytoskeleton organizationGO:00300362070.021
dna damage checkpointGO:0000077680.021
Fly
positive regulation of chromosome organizationGO:2001252410.021
negative regulation of bindingGO:0051100570.021
forelimb morphogenesisGO:003513640.020
response to hormoneGO:00097251750.020
regulation of chromatin modificationGO:1903308510.020
regulation of mitotic cell cycle phase transitionGO:19019901180.020
Fly
negative regulation of hydrolase activityGO:00513461820.020
negative regulation of mitotic cell cycle phase transitionGO:1901991850.020
Fly
multi organism cellular processGO:00447641560.020
regulation of defense responseGO:00313471540.020
locomotory behaviorGO:000762610.020
response to tumor necrosis factorGO:0034612760.019
endocytosisGO:00068971590.019
peptidyl tyrosine phosphorylationGO:00181081700.019
purine ribonucleoside triphosphate metabolic processGO:00092054110.019
cellular response to endogenous stimulusGO:00714953360.019
regulation of gene expression epigeneticGO:0040029730.019
growthGO:00400072020.019
regulation of protein stabilityGO:0031647870.019
response to alcoholGO:0097305640.019
negative regulation of cellular amino acid metabolic processGO:004576320.019
regulation of histone modificationGO:0031056470.019
stress activated mapk cascadeGO:0051403930.019
negative regulation of cell cycleGO:00457861930.019
Fly
cytoplasmic transportGO:00164823790.018
negative regulation of intrinsic apoptotic signaling pathwayGO:2001243400.018
regulation of peptidase activityGO:00525471800.018
positive regulation of canonical wnt signaling pathwayGO:0090263330.018
dna integrity checkpointGO:0031570710.018
Fly
glycosylationGO:0070085710.018
microtubule based processGO:00070172100.018
Fly
protein targetingGO:00066051870.018
blood vessel morphogenesisGO:00485141620.018
protein localization to organelleGO:00333652800.017
response to oxygen containing compoundGO:19017003690.017
double strand break repairGO:00063021010.017
cell morphogenesisGO:00009022960.017
rna interferenceGO:001624640.017
negative regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043154460.017
tube morphogenesisGO:0035239950.017
negative regulation of chromosome organizationGO:2001251480.017
positive regulation of response to dna damage stimulusGO:2001022430.017
negative regulation of protein modification processGO:00314002000.017
negative regulation of peptidase activityGO:0010466910.017
neurological system processGO:00508771630.017
regulation of protein localizationGO:00328802960.017
atp metabolic processGO:00460341760.016
cellular response to abiotic stimulusGO:00712141170.016
actin filament based processGO:00300292240.016
positive regulation of viral processGO:0048524370.016
negative regulation of intracellular signal transductionGO:19025321830.016
negative regulation of multicellular organismal processGO:00512413170.016
glycoprotein biosynthetic processGO:0009101910.016
response to ionizing radiationGO:0010212650.016
cell cycle checkpointGO:00000751170.016
Fly
regulation of mapk cascadeGO:00434082620.016
neuromuscular junction developmentGO:000752830.016
cytokine mediated signaling pathwayGO:00192211090.016
organophosphate catabolic processGO:00464344300.016
negative regulation of cysteine type endopeptidase activityGO:2000117480.016
negative regulation of growthGO:0045926970.016
positive regulation of phosphorylationGO:00423273940.016
cellular response to organic cyclic compoundGO:00714071270.016
regulation of cellular protein catabolic processGO:1903362960.015
peptidyl tyrosine modificationGO:00182121700.015
oocyte developmentGO:004859910.015
mapk cascadeGO:00001652880.015
regulation of dna repairGO:0006282470.015
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280690.015
positive regulation of histone modificationGO:0031058290.015
regulation of protein complex assemblyGO:00432541470.015
anatomical structure formation involved in morphogenesisGO:00486462840.015
negative regulation of phosphorus metabolic processGO:00105632670.015
tube closureGO:006060630.015
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.014
regulation of anatomical structure sizeGO:00900661010.014
intrinsic apoptotic signaling pathway by p53 class mediatorGO:0072332370.014
Mouse
hemopoiesisGO:00300971800.014
negative regulation of cellular response to oxidative stressGO:1900408180.014
immune responseGO:00069553070.014
mitotic cell cycle processGO:19030472860.014
Fly
regulation of canonical wnt signaling pathwayGO:0060828880.014
regulation of extrinsic apoptotic signaling pathwayGO:2001236850.014
microtubule cytoskeleton organizationGO:00002261760.014
Fly
cellular response to nitrogen compoundGO:19016991440.014
tube developmentGO:00352951250.014
purine nucleotide catabolic processGO:00061954050.014
cell growthGO:00160491600.014
response to lipopolysaccharideGO:0032496700.014
regulation of neural precursor cell proliferationGO:200017740.014
cellular response to extracellular stimulusGO:0031668720.014
cellular response to external stimulusGO:00714961110.013
positive regulation of immune responseGO:00507781590.013
secretion by cellGO:00329402260.013
blood vessel developmentGO:00015681720.013
nitrogen compound transportGO:00717051910.013
purine ribonucleotide catabolic processGO:00091544040.013
regulation of membrane potentialGO:0042391950.013
innate immune responseGO:00450871780.013
negative regulation of secretion by cellGO:1903531520.013
response to other organismGO:00517072610.013
stress activated protein kinase signaling cascadeGO:0031098940.013
regulation of cytoplasmic transportGO:19036491490.013
positive regulation of multi organism processGO:0043902560.013
positive regulation of immune system processGO:00026842830.013
regulation of viral transcriptionGO:0046782340.013
ribonucleoside triphosphate metabolic processGO:00091994120.013
response to woundingGO:00096111680.013
purine ribonucleoside metabolic processGO:00461284370.013
response to biotic stimulusGO:00096072760.013
cardiovascular system developmentGO:00723582620.013
response to external biotic stimulusGO:00432072610.013
regulation of protein modification by small protein conjugation or removalGO:19033201070.013
chromatin organizationGO:00063253510.012
intrinsic apoptotic signaling pathway in response to oxidative stressGO:0008631210.012
regulation of proteasomal protein catabolic processGO:0061136870.012
vasculature developmentGO:00019441810.012
positive regulation of synaptic transmissionGO:005080640.012
circadian sleep wake cycle sleepGO:005080220.012
nucleoside triphosphate metabolic processGO:00091414220.012
regulation of intracellular transportGO:00323861950.012
methylationGO:00322591060.012
atp catabolic processGO:00062001570.012
cell cycle phase transitionGO:00447701730.012
Fly
positive regulation of protein modification by small protein conjugation or removalGO:1903322610.012
regulation of dna metabolic processGO:00510521530.012
cellular response to hormone stimulusGO:00328701250.012
response to bacteriumGO:00096171440.012
response to oxidative stressGO:00069791210.012
response to extracellular stimulusGO:0009991850.012
associative learningGO:000830610.012
neurotransmitter secretionGO:000726940.011
negative regulation of cell growthGO:0030308830.011
purine nucleoside monophosphate catabolic processGO:00091281580.011
response to nitrogen compoundGO:19016981840.011
regulation of oxidative stress induced cell deathGO:1903201240.011
response to cytokineGO:00340972320.011
regulation of secretion by cellGO:19035301770.011
positive regulation of cysteine type endopeptidase activityGO:2001056790.011
neuroblast proliferationGO:000740540.011
mitotic sister chromatid segregationGO:0000070530.011
positive regulation of cell cycleGO:00457871400.011
cellular homeostasisGO:00197251960.011
purine containing compound catabolic processGO:00725234110.011
jnk cascadeGO:0007254800.011
oogenesisGO:004847720.011
regulation of peptidyl tyrosine phosphorylationGO:00507301080.011
symbiosis encompassing mutualism through parasitismGO:00444031560.011
histone exchangeGO:004348630.011
positive regulation of hydrolase activityGO:00513453310.011
sister chromatid segregationGO:0000819540.010
regulation of multi organism processGO:00439001570.010
protein alkylationGO:0008213740.010
purine nucleoside triphosphate metabolic processGO:00091444120.010
negative regulation of response to external stimulusGO:0032102830.010
rna splicing via transesterification reactionsGO:0000375900.010
internal peptidyl lysine acetylationGO:0018393970.010
cell type specific apoptotic processGO:00972851250.010
regulation of transferase activityGO:00513383550.010
organophosphate biosynthetic processGO:00904071630.010
purine ribonucleoside triphosphate catabolic processGO:00092073910.010
cellular component morphogenesisGO:00329893140.010
ossificationGO:00015031210.010
nucleosome organizationGO:0034728660.010
establishment or maintenance of epithelial cell apical basal polarityGO:004519710.010
nucleosome positioningGO:001658430.010

TOPORS disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:145661740.086
organ system cancerDOID:00506861640.086
cancerDOID:1621670.086
gastrointestinal system cancerDOID:3119520.014
bone diseaseDOID:0080001880.013
connective tissue diseaseDOID:651090.013
musculoskeletal system diseaseDOID:172230.013
thoracic cancerDOID:5093210.012
breast cancerDOID:1612210.012
eye and adnexa diseaseDOID:14921500.011
nervous system diseaseDOID:8634310.011
sensory system diseaseDOID:00501552030.011
eye diseaseDOID:56141490.005
retinal diseaseDOID:56791180.005
retinal degenerationDOID:8466890.005
retinitis pigmentosaDOID:10584510.005