Homo sapiens

16 known processes

HMGCR

3-hydroxy-3-methylglutaryl-CoA reductase

(Aliases: LDLCQ3)

HMGCR biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
steroid metabolic processGO:0008202940.999
Mouse
alcohol metabolic processGO:00060661140.996
Mouse
lipid biosynthetic processGO:00086101770.995
Mouse
cellular lipid metabolic processGO:00442553030.986
lipid metabolic processGO:00066293810.976
Mouse
organic hydroxy compound metabolic processGO:19016151470.960
Mouse
small molecule biosynthetic processGO:00442831570.922
Mouse
sterol metabolic processGO:0016125280.910
Mouse
monocarboxylic acid biosynthetic processGO:0072330670.908
organic hydroxy compound biosynthetic processGO:1901617710.890
Mouse
phospholipid metabolic processGO:0006644990.881
cellular biogenic amine metabolic processGO:0006576340.873
phospholipid biosynthetic processGO:0008654440.858
alcohol biosynthetic processGO:0046165520.833
Mouse
organophosphate biosynthetic processGO:00904071630.718
cellular response to cholesterolGO:007139740.639
anion transportGO:00068201610.632
sterol biosynthetic processGO:0016126100.584
Mouse
response to lipidGO:00339932060.499
regulation of vesicle mediated transportGO:00606271300.485
long chain fatty acid importGO:004453950.452
response to organic cyclic compoundGO:00140702040.427
carboxylic acid biosynthetic processGO:0046394970.395
regulation of icosanoid secretionGO:003230340.393
regulation of cytoplasmic transportGO:19036491490.384
inner ear morphogenesisGO:004247240.347
response to drugGO:0042493810.278
terpenoid biosynthetic processGO:001611420.258
glycerolipid metabolic processGO:00464861070.250
positive regulation of golgi to plasma membrane protein transportGO:004299820.245
acylglycerol metabolic processGO:0006639270.234
negative regulation of growth of symbiont involved in interaction with hostGO:004414620.227
membrane buddingGO:0006900280.224
cholesterol metabolic processGO:0008203280.222
Mouse
srebp signaling pathwayGO:003293340.158
negative regulation of lipid metabolic processGO:0045833380.151
steroid biosynthetic processGO:0006694460.145
Mouse
head developmentGO:00603221080.145
cellular response to gonadotropin stimulusGO:007137140.130
regulation of protein complex assemblyGO:00432541470.121
response to sterol depletionGO:000699140.120
cellular response to sterol depletionGO:007150140.118
amine metabolic processGO:0009308440.117
sphingolipid metabolic processGO:0006665380.106
terpenoid metabolic processGO:0006721270.103
cellular amine metabolic processGO:0044106410.100
regulation of cellular ketone metabolic processGO:0010565500.097
growthGO:00400072020.089
vesicle organizationGO:0016050620.087
sensory organ morphogenesisGO:0090596210.081
membrane organizationGO:00610242920.080
single organism cellular localizationGO:19025803320.078
sulfur compound metabolic processGO:00067901010.076
regulation of lipid metabolic processGO:0019216960.073
regulation of cell growthGO:00015581350.072
positive regulation of cellular amine metabolic processGO:003324070.070
cellular response to organic cyclic compoundGO:00714071270.070
cytoplasmic transportGO:00164823790.069
triglyceride metabolic processGO:0006641230.068
fatty acid elongation polyunsaturated fatty acidGO:003462640.066
golgi vesicle transportGO:0048193800.065
organonitrogen compound biosynthetic processGO:19015662000.063
very long chain fatty acid biosynthetic processGO:004276170.062
organic acid biosynthetic processGO:0016053970.061
determination of adult lifespanGO:000834020.061
monocarboxylic acid metabolic processGO:00327871850.060
fatty acid metabolic processGO:00066311150.059
regulation of golgi to plasma membrane protein transportGO:004299630.059
regulation of intracellular transportGO:00323861950.058
positive regulation of phospholipid biosynthetic processGO:007107340.054
negative regulation of cellular component organizationGO:00511292350.054
nervous system developmentGO:00073992930.052
cellular response to oxygen containing compoundGO:19017012760.050
endomembrane system organizationGO:00102561960.048
purine containing compound catabolic processGO:00725234110.047
regulation of er to golgi vesicle mediated transportGO:006062850.047
negative regulation of secretionGO:0051048580.046
purine nucleoside triphosphate catabolic processGO:00091463920.045
mitotic cell cycle processGO:19030472860.045
single organism membrane organizationGO:00448022680.043
cellular alcohol metabolic processGO:004410770.042
sterol transportGO:0015918390.041
negative regulation of protein complex assemblyGO:0031333430.041
regulation of ion transportGO:00432691890.041
oogenesisGO:004847720.041
neuromuscular junction developmentGO:000752830.040
cellular protein complex assemblyGO:00436231880.039
cholesterol biosynthetic processGO:0006695100.039
Mouse
regulation of cellular component biogenesisGO:00440872810.039
central nervous system developmentGO:00074171230.039
positive regulation of cellular amino acid metabolic processGO:004576430.039
regulation of protein localization to plasma membraneGO:1903076400.038
ion transmembrane transportGO:00342203380.038
ribonucleoside triphosphate metabolic processGO:00091994120.037
male sex differentiationGO:0046661250.037
regulation of cellular amine metabolic processGO:0033238110.037
ketone body metabolic processGO:190222420.037
nucleotide catabolic processGO:00091664080.036
2 oxoglutarate metabolic processGO:000610340.035
lipid transportGO:0006869900.035
secretionGO:00469032540.035
organophosphate catabolic processGO:00464344300.034
post embryonic developmentGO:000979120.033
Worm
positive regulation of cell growthGO:0030307480.033
negative regulation of protein metabolic processGO:00512483910.033
Mouse
prostaglandin secretionGO:003231020.032
er to golgi vesicle mediated transportGO:0006888190.032
glycerophospholipid metabolic processGO:0006650840.032
reproductive system developmentGO:0061458560.031
negative regulation of growth of symbiont in hostGO:004413010.031
fatty acid biosynthetic processGO:0006633460.031
cellular response to hormone stimulusGO:00328701250.031
response to external biotic stimulusGO:00432072610.031
response to light stimulusGO:0009416870.031
Mouse
negative regulation of cellular protein metabolic processGO:00322693530.030
Mouse
inorganic ion transmembrane transportGO:00986602310.030
regulation of cell cycleGO:00517263930.030
locomotory behaviorGO:000762610.030
glycerolipid biosynthetic processGO:0045017510.030
female gamete generationGO:000729220.029
localization within membraneGO:0051668140.029
negative regulation of catalytic activityGO:00430863350.029
Mouse
cellular response to lipidGO:00713961270.029
brain developmentGO:0007420970.029
embryo developmentGO:00097901230.029
Mouse Worm
positive regulation of cytoplasmic transportGO:1903651820.028
regulation of cellular amino acid metabolic processGO:000652160.028
cation transmembrane transportGO:00986552380.027
regulation of steroid biosynthetic processGO:0050810230.027
regulation of growthGO:00400081650.027
glycerophospholipid biosynthetic processGO:0046474400.027
cholesterol transportGO:0030301390.027
cellular amino acid metabolic processGO:00065201160.026
positive regulation of secretionGO:00510471160.026
positive regulation of transportGO:00510503360.026
cell growthGO:00160491600.026
vesicle mediated transportGO:00161923710.026
Worm
purine ribonucleoside triphosphate metabolic processGO:00092054110.026
response to abiotic stimulusGO:00096283360.025
Mouse
negative regulation of icosanoid secretionGO:003230420.024
response to nutrient levelsGO:0031667810.024
ion homeostasisGO:00508012300.024
divalent inorganic cation homeostasisGO:00725071360.023
inorganic cation transmembrane transportGO:00986621940.023
regulation of lipid biosynthetic processGO:0046890470.023
single organism membrane buddingGO:1902591100.023
regulation of establishment of protein localizationGO:00702012420.023
defense responseGO:00069523150.022
nucleoside catabolic processGO:00091644080.022
response to biotic stimulusGO:00096072760.022
multicellular organismal agingGO:001025930.022
regulation of protein localizationGO:00328802960.022
ribonucleoside catabolic processGO:00424544060.022
embryonic morphogenesisGO:0048598850.022
regulation of cell differentiationGO:00455953930.021
transmembrane transportGO:00550853990.021
ribonucleoside triphosphate catabolic processGO:00092033910.021
segmentationGO:003528240.021
innate immune responseGO:00450871780.021
negative regulation of transportGO:00510511760.021
positive regulation of intracellular transportGO:00323881040.021
chemical homeostasisGO:00488783060.021
response to inorganic substanceGO:00100351270.020
negative regulation of organelle organizationGO:00106391260.020
microtubule based processGO:00070172100.020
positive regulation of lipid biosynthetic processGO:0046889220.020
ethanolamine containing compound metabolic processGO:0042439260.020
positive regulation of protein transportGO:00512221350.020
positive regulation of cellular component organizationGO:00511303760.020
purine nucleotide catabolic processGO:00061954050.020
regulation of steroid metabolic processGO:0019218320.020
purine nucleoside triphosphate metabolic processGO:00091444120.020
ribonucleotide catabolic processGO:00092614050.020
metal ion transportGO:00300012720.019
glycosyl compound catabolic processGO:19016584130.019
intracellular protein transportGO:00068862700.019
negative regulation of protein processingGO:00109551420.019
cell fate determinationGO:000170930.019
cellular divalent inorganic cation homeostasisGO:00725031280.019
protein targetingGO:00066051870.019
cellular macromolecular complex assemblyGO:00346223240.018
response to extracellular stimulusGO:0009991850.018
regulation of fatty acid transportGO:200019180.018
dna repairGO:00062811980.018
spermatid differentiationGO:004851540.018
phosphatidylcholine catabolic processGO:003463830.018
organ morphogenesisGO:00098871470.017
nucleoside triphosphate catabolic processGO:00091433940.017
cellular macromolecule catabolic processGO:00442653800.017
dephosphorylationGO:00163112090.017
ras protein signal transductionGO:0007265730.017
positive regulation of cell cycleGO:00457871400.016
fatty acid elongation monounsaturated fatty acidGO:003462530.016
purine ribonucleoside triphosphate catabolic processGO:00092073910.016
establishment of protein localization to membraneGO:00901501210.016
negative regulation of phosphate metabolic processGO:00459362670.016
Mouse
mitotic cell cycleGO:00002783260.016
establishment or maintenance of bipolar cell polarityGO:006124520.016
regulation of neuronal synaptic plasticityGO:004816810.016
regulation of protein kinase activityGO:00458592890.016
Mouse
stem cell divisionGO:001714520.016
regulation of protein transportGO:00512232130.016
purine ribonucleoside metabolic processGO:00461284370.016
ear morphogenesisGO:004247170.015
ribonucleoside monophosphate catabolic processGO:00091581580.015
immune system developmentGO:00025201950.015
nucleoside phosphate catabolic processGO:19012924120.015
cell part morphogenesisGO:00329901370.015
negative regulation of cellular amino acid metabolic processGO:004576320.015
posttranscriptional regulation of gene expressionGO:00106082130.015
response to nutrientGO:0007584200.015
regulation of fatty acid metabolic processGO:0019217240.015
negative regulation of proteolysisGO:00458611320.015
cellular response to sterolGO:003631570.015
endocytosisGO:00068971590.015
Worm
establishment of protein localization to organelleGO:00725941720.015
bone morphogenesisGO:0060349100.015
cellular chemical homeostasisGO:00550821800.015
glycoprotein metabolic processGO:00091001100.015
positive regulation of catabolic processGO:00098963100.015
purine ribonucleoside monophosphate catabolic processGO:00091691580.014
nucleoside triphosphate metabolic processGO:00091414220.014
purine ribonucleotide catabolic processGO:00091544040.014
protein processingGO:00164852260.014
regulation of proteolysisGO:00301622930.014
golgi to plasma membrane transportGO:0006893210.014
lipid storageGO:0019915280.014
Worm
negative regulation of protein kinase activityGO:0006469980.014
Mouse
actin cytoskeleton organizationGO:00300362070.014
negative regulation of developmental processGO:00510932470.014
carboxylic acid transportGO:0046942630.014
protein import into nucleusGO:00066061040.014
monocarboxylic acid transportGO:0015718320.013
very long chain fatty acid metabolic processGO:0000038190.013
protein localization to plasma membraneGO:0072659930.013
negative regulation of cytoplasmic transportGO:1903650460.013
nucleoside monophosphate metabolic processGO:00091231910.013
protein importGO:00170381300.013
rab protein signal transductionGO:003248240.013
skin developmentGO:0043588760.013
isocitrate metabolic processGO:000610210.013
cellular metal ion homeostasisGO:00068751460.013
cellular ion homeostasisGO:00068731680.013
regulation of cell motilityGO:20001452990.013
response to hormoneGO:00097251750.013
membrane lipid metabolic processGO:0006643530.013
neurogenesisGO:00220081690.013
regulation of synaptic plasticityGO:004816730.013
reproductive processGO:00224141060.013
protein localization to membraneGO:00726571600.013
spermatid developmentGO:000728640.013
organelle localizationGO:0051640840.013
neuron projection developmentGO:00311751060.013
protein catabolic processGO:00301633250.012
purine ribonucleoside catabolic processGO:00461303980.012
calcium ion homeostasisGO:00550741220.012
response to oxygen containing compoundGO:19017003690.012
neurological system processGO:00508771630.012
Mouse
cardiovascular system developmentGO:00723582620.012
cation homeostasisGO:00550801890.012
neutral lipid metabolic processGO:0006638270.012
regulation of protein serine threonine kinase activityGO:00719001790.012
Mouse
oocyte developmentGO:004859910.012
establishment or maintenance of apical basal cell polarityGO:003508820.012
response to steroid hormoneGO:0048545800.012
blastoderm segmentationGO:000735020.012
establishment or maintenance of cytoskeleton polarityGO:003095230.012
monovalent inorganic cation transportGO:00156721280.012
regulation of anion transportGO:0044070250.012
long chain fatty acid transportGO:0015909180.011
regulation of kinase activityGO:00435493140.011
Mouse
anterior posterior axis specificationGO:000994820.011
peripheral nervous system developmentGO:000742220.011
neurotransmitter secretionGO:000726940.011
meiotic chromosome segregationGO:004513240.011
regulation of cell divisionGO:00513021160.011
multicellular organismal response to stressGO:003355510.011
adult locomotory behaviorGO:000834410.011
atp metabolic processGO:00460341760.011
organic anion transportGO:00157111030.011
morphogenesis of embryonic epitheliumGO:001633140.011
cholesterol importGO:007050840.011
cellular homeostasisGO:00197251960.011
neuroblast proliferationGO:000740540.011
lipid catabolic processGO:0016042840.011
coenzyme metabolic processGO:0006732650.011
fatty acid derivative transportGO:1901571110.011
positive regulation of intracellular protein transportGO:0090316760.011
protein lipid complex subunit organizationGO:0071825240.011
positive regulation of nucleotide metabolic processGO:00459812300.011
positive regulation of immune system processGO:00026842830.010
guanosine containing compound catabolic processGO:19010692390.010
guanosine containing compound metabolic processGO:19010682440.010
positive regulation of cell migrationGO:00303351720.010
regulation of protein processingGO:00706131500.010
neural tube formationGO:000184130.010
gtp catabolic processGO:00061842370.010
negative regulation of cell differentiationGO:00455961710.010
regulation of organic acid transportGO:003289080.010
regulation of response to external stimulusGO:00321012220.010
single organism reproductive processGO:0044702980.010
negative regulation of transferase activityGO:00513481240.010
Mouse
oocyte differentiationGO:000999420.010
negative regulation of phosphorylationGO:00423261740.010
Mouse
reactive nitrogen species metabolic processGO:200105730.010
negative regulation of cellular amine metabolic processGO:003323930.010
regulation of meiotic cell cycleGO:005144540.010
regulation of cell cycle processGO:00105642660.010
regulation of purine nucleotide catabolic processGO:00331212050.010
negative regulation of apoptotic processGO:00430663160.010
system processGO:00030083490.010
Mouse
response to cytokineGO:00340972320.010

HMGCR disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:145661740.076
lipid metabolism disorderDOID:3146260.029
inherited metabolic disorderDOID:6552420.029
disease of metabolismDOID:00146672950.029
familial hyperlipidemiaDOID:116890.024
cancerDOID:1621670.021
disease of mental healthDOID:150700.014
immune system diseaseDOID:29141550.014
central nervous system diseaseDOID:3311860.011
nervous system diseaseDOID:8634310.011
sensory system diseaseDOID:00501552030.011