IMP: Integrative Multi-species Prediction

Homo sapiens

0 known processes

IARS2

isoleucyl-tRNA synthetase 2, mitochondrial

(Aliases: ILERS,FLJ10326)

HGNC: 29685
Ensembl: ENSG00000067704
Entrez: 55699
HPRD: 13334
MIM: 612801
UniProtKB: Q9NSE4

Process Predictions
Disease Predictions

IARS2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
purine ribonucleoside monophosphate metabolic process	GO:0009167	186	0.478
atp metabolic process	GO:0046034	176	0.393
lipid metabolic process	GO:0006629	381	0.371
ribonucleoside triphosphate metabolic process	GO:0009199	412	0.367
purine ribonucleoside triphosphate metabolic process	GO:0009205	411	0.356
oxidation reduction process	GO:0055114	396	0.348
nucleoside catabolic process	GO:0009164	408	0.322
ribonucleoside monophosphate metabolic process	GO:0009161	187	0.320
nucleoside monophosphate metabolic process	GO:0009123	191	0.310
purine nucleoside triphosphate metabolic process	GO:0009144	412	0.267
purine nucleoside monophosphate metabolic process	GO:0009126	186	0.257
purine nucleoside triphosphate catabolic process	GO:0009146	392	0.221
purine ribonucleoside metabolic process	GO:0046128	437	0.194
purine ribonucleoside catabolic process	GO:0046130	398	0.171
ribonucleoside triphosphate catabolic process	GO:0009203	391	0.149
glycosyl compound catabolic process	GO:1901658	413	0.146
nucleoside triphosphate catabolic process	GO:0009143	394	0.129
purine containing compound catabolic process	GO:0072523	411	0.122
purine nucleoside monophosphate catabolic process	GO:0009128	158	0.117
ribonucleoside catabolic process	GO:0042454	406	0.113
purine ribonucleoside monophosphate catabolic process	GO:0009169	158	0.100
post embryonic development	GO:0009791	2	0.099
purine nucleotide catabolic process	GO:0006195	405	0.087
membrane organization	GO:0061024	292	0.082
positive regulation of proteolysis	GO:0045862	142	0.081
ribonucleotide catabolic process	GO:0009261	405	0.077
mitochondrial membrane organization	GO:0007006	40	0.077
positive regulation of hydrolase activity	GO:0051345	331	0.076
sulfur compound metabolic process	GO:0006790	101	0.073
nucleoside monophosphate catabolic process	GO:0009125	159	0.073
apoptotic mitochondrial changes	GO:0008637	57	0.069
carbohydrate derivative biosynthetic process	GO:1901137	207	0.069
monocarboxylic acid metabolic process	GO:0032787	185	0.065
mitochondrial transport	GO:0006839	60	0.065
inorganic ion transmembrane transport	GO:0098660	231	0.064
cellular lipid metabolic process	GO:0044255	303	0.063
ribonucleotide biosynthetic process	GO:0009260	81	0.060
fatty acid metabolic process	GO:0006631	115	0.060
cellular amino acid metabolic process	GO:0006520	116	0.059
oogenesis	GO:0048477	2	0.057
vesicle mediated transport	GO:0016192	371	0.056	Worm
nucleotide catabolic process	GO:0009166	408	0.055
establishment of protein localization to organelle	GO:0072594	172	0.053
organophosphate catabolic process	GO:0046434	430	0.052
purine ribonucleoside triphosphate catabolic process	GO:0009207	391	0.052
wound healing	GO:0042060	115	0.051
positive regulation of catabolic process	GO:0009896	310	0.051
regulation of membrane potential	GO:0042391	95	0.050
nucleoside phosphate catabolic process	GO:1901292	412	0.049
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.045
cellular modified amino acid metabolic process	GO:0006575	64	0.044
transmembrane transport	GO:0055085	399	0.043
multicellular organismal aging	GO:0010259	3	0.042
cellular ketone metabolic process	GO:0042180	80	0.042
nucleoside triphosphate metabolic process	GO:0009141	422	0.041
single organism membrane organization	GO:0044802	268	0.040
microtubule based process	GO:0007017	210	0.040
regulation of peptidase activity	GO:0052547	180	0.039
ion transmembrane transport	GO:0034220	338	0.038
response to other organism	GO:0051707	261	0.038
positive regulation of cellular catabolic process	GO:0031331	284	0.037
protein targeting	GO:0006605	187	0.037
lipid biosynthetic process	GO:0008610	177	0.036
ribonucleoside monophosphate catabolic process	GO:0009158	158	0.035
positive regulation of peptidase activity	GO:0010952	88	0.034
endocytosis	GO:0006897	159	0.034	Worm
embryo development	GO:0009790	123	0.034	Worm
cytoplasmic transport	GO:0016482	379	0.033
determination of adult lifespan	GO:0008340	2	0.033
ras protein signal transduction	GO:0007265	73	0.033
regulation of endopeptidase activity	GO:0052548	170	0.033
protein processing	GO:0016485	226	0.032
amino acid activation	GO:0043038	12	0.032
response to wounding	GO:0009611	168	0.031
metal ion transport	GO:0030001	272	0.031
system process	GO:0003008	349	0.031
cellular macromolecular complex assembly	GO:0034622	324	0.029
spermatid differentiation	GO:0048515	4	0.029
atp catabolic process	GO:0006200	157	0.028
defense response	GO:0006952	315	0.028
negative regulation of apoptotic process	GO:0043066	316	0.028
small gtpase mediated signal transduction	GO:0007264	78	0.028
regulation of proteolysis	GO:0030162	293	0.027
acetyl coa biosynthetic process from pyruvate	GO:0006086	4	0.027
negative regulation of programmed cell death	GO:0043069	321	0.026
purine nucleoside catabolic process	GO:0006152	398	0.026
purine ribonucleotide catabolic process	GO:0009154	404	0.025
mitotic spindle elongation	GO:0000022	4	0.024
cation transmembrane transport	GO:0098655	238	0.024
sleep	GO:0030431	2	0.024
inorganic cation transmembrane transport	GO:0098662	194	0.023
negative regulation of catalytic activity	GO:0043086	335	0.023
cellular protein complex assembly	GO:0043623	188	0.023
cellular metal ion homeostasis	GO:0006875	146	0.022
innate immune response	GO:0045087	178	0.022
anatomical structure homeostasis	GO:0060249	100	0.022
response to drug	GO:0042493	81	0.022
ribose phosphate biosynthetic process	GO:0046390	82	0.022
cell activation	GO:0001775	213	0.022
tissue regeneration	GO:0042246	3	0.021
covalent chromatin modification	GO:0016569	254	0.021
cellular amide metabolic process	GO:0043603	69	0.021
purine nucleotide biosynthetic process	GO:0006164	84	0.021
sulfur compound biosynthetic process	GO:0044272	38	0.021
immune response	GO:0006955	307	0.021
response to endoplasmic reticulum stress	GO:0034976	49	0.021
monovalent inorganic cation transport	GO:0015672	128	0.021
neuromuscular junction development	GO:0007528	3	0.021
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	49	0.021
organelle fusion	GO:0048284	36	0.020
single organism cell adhesion	GO:0098602	179	0.020
cation homeostasis	GO:0055080	189	0.020
female gamete generation	GO:0007292	2	0.020
ion homeostasis	GO:0050801	230	0.020
oocyte development	GO:0048599	1	0.020
behavior	GO:0007610	112	0.020
tissue homeostasis	GO:0001894	63	0.020
regulation of lipid metabolic process	GO:0019216	96	0.020
peripheral nervous system development	GO:0007422	2	0.019
cofactor metabolic process	GO:0051186	87	0.019
hemostasis	GO:0007599	76	0.019
neuron projection development	GO:0031175	106	0.019
cell morphogenesis	GO:0000902	296	0.019
response to external biotic stimulus	GO:0043207	261	0.018
response to biotic stimulus	GO:0009607	276	0.018
cell adhesion	GO:0007155	325	0.018
anterior posterior axis specification	GO:0009948	2	0.018
lipid localization	GO:0010876	106	0.018
mitochondrion organization	GO:0007005	156	0.018
regeneration	GO:0031099	4	0.018
guanosine containing compound metabolic process	GO:1901068	244	0.017
dicarboxylic acid metabolic process	GO:0043648	29	0.017
digestive tract development	GO:0048565	75	0.017
regulation of purine nucleotide catabolic process	GO:0033121	205	0.017
guanosine containing compound catabolic process	GO:1901069	239	0.017
cellular cation homeostasis	GO:0030003	163	0.016
oocyte differentiation	GO:0009994	2	0.016
glycerolipid metabolic process	GO:0046486	107	0.016
cellular component morphogenesis	GO:0032989	314	0.016
single organism cellular localization	GO:1902580	332	0.016
positive regulation of cellular component organization	GO:0051130	376	0.016
associative learning	GO:0008306	1	0.016
protein localization to mitochondrion	GO:0070585	25	0.016
positive regulation of apoptotic process	GO:0043065	246	0.016
purine ribonucleotide biosynthetic process	GO:0009152	79	0.016
actin filament based movement	GO:0030048	17	0.016
regulation of protein catabolic process	GO:0042176	155	0.016
regulation of multi organism process	GO:0043900	157	0.015
cell cell signaling	GO:0007267	155	0.015
cell projection morphogenesis	GO:0048858	129	0.015
regulation of mitochondrion organization	GO:0010821	54	0.015
regulation of apoptotic signaling pathway	GO:2001233	175	0.015
establishment of organelle localization	GO:0051656	59	0.015
regulation of mitochondrial membrane potential	GO:0051881	23	0.015
regulation of cytokine production	GO:0001817	232	0.015
secretion by cell	GO:0032940	226	0.015
response to bacterium	GO:0009617	144	0.015
cellular ion homeostasis	GO:0006873	168	0.014
cell part morphogenesis	GO:0032990	137	0.014
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	69	0.014
cardiac muscle contraction	GO:0060048	34	0.014
positive regulation of cytokine production	GO:0001819	167	0.014
protein oligomerization	GO:0051259	173	0.014
single organismal cell cell adhesion	GO:0016337	148	0.014
zymogen activation	GO:0031638	70	0.014
spermatid development	GO:0007286	4	0.014
regulation of small gtpase mediated signal transduction	GO:0051056	156	0.014
regulation of response to external stimulus	GO:0032101	222	0.013
membrane fusion	GO:0061025	43	0.013
tube development	GO:0035295	125	0.013
blastoderm segmentation	GO:0007350	2	0.013
regulation of cell cycle	GO:0051726	393	0.013
mitotic cell cycle	GO:0000278	326	0.013
protein localization to organelle	GO:0033365	280	0.013
regulation of cellular amine metabolic process	GO:0033238	11	0.013
peptidyl serine modification	GO:0018209	106	0.013
negative regulation of phosphate metabolic process	GO:0045936	267	0.013
chaperone mediated protein folding	GO:0061077	13	0.013
cellular chemical homeostasis	GO:0055082	180	0.013
response to lipid	GO:0033993	206	0.013
growth	GO:0040007	202	0.012
endomembrane system organization	GO:0010256	196	0.012
chemical homeostasis	GO:0048878	306	0.012
intracellular protein transport	GO:0006886	270	0.012
brain morphogenesis	GO:0048854	1	0.012
small molecule biosynthetic process	GO:0044283	157	0.012
receptor mediated endocytosis	GO:0006898	84	0.012	Worm
cellular response to vascular endothelial growth factor stimulus	GO:0035924	26	0.012
fatty acid derivative biosynthetic process	GO:1901570	18	0.012
adult locomotory behavior	GO:0008344	1	0.012
actin filament based process	GO:0030029	224	0.012
peptide metabolic process	GO:0006518	51	0.012
protein targeting to mitochondrion	GO:0006626	19	0.012
cell projection organization	GO:0030030	252	0.012
embryo development ending in birth or egg hatching	GO:0009792	34	0.012	Worm
amine metabolic process	GO:0009308	44	0.012
locomotory behavior	GO:0007626	1	0.012
reproduction	GO:0000003	63	0.012	Worm
segmentation	GO:0035282	4	0.012
nucleoside phosphate biosynthetic process	GO:1901293	109	0.012
gtp metabolic process	GO:0046039	239	0.011
organelle localization	GO:0051640	84	0.011
establishment of protein localization to mitochondrion	GO:0072655	22	0.011
cytokine production	GO:0001816	247	0.011
cell development	GO:0048468	328	0.011
maintenance of location	GO:0051235	112	0.011
immune system development	GO:0002520	195	0.011
cell type specific apoptotic process	GO:0097285	125	0.011
regulation of ras protein signal transduction	GO:0046578	155	0.011
cardiac muscle cell contraction	GO:0086003	4	0.011
rna localization	GO:0006403	41	0.011
regulation of ion transport	GO:0043269	189	0.011
nitrogen compound transport	GO:0071705	191	0.011
multicellular organismal homeostasis	GO:0048871	67	0.011
negative regulation of hydrolase activity	GO:0051346	182	0.011
morphogenesis of embryonic epithelium	GO:0016331	4	0.011
metal ion homeostasis	GO:0055065	169	0.011
response to inorganic substance	GO:0010035	127	0.011
nucleocytoplasmic transport	GO:0006913	176	0.011
intracellular mrna localization	GO:0008298	1	0.011
reactive oxygen species metabolic process	GO:0072593	75	0.010
gtp catabolic process	GO:0006184	237	0.010
response to cytokine	GO:0034097	232	0.010
proteasomal protein catabolic process	GO:0010498	176	0.010
ubiquitin dependent protein catabolic process	GO:0006511	206	0.010
protein import	GO:0017038	130	0.010
positive regulation of cellular amine metabolic process	GO:0033240	7	0.010
secretion	GO:0046903	254	0.010

IARS2 disease predictions

Disease	DO term ID	Size	Probability
nervous system disease	DOID:863	431	0.250
central nervous system disease	DOID:331	186	0.250
disease of metabolism	DOID:0014667	295	0.099
amino acid metabolic disorder	DOID:9252	50	0.099
inherited metabolic disorder	DOID:655	242	0.099
neurodegenerative disease	DOID:1289	102	0.044
disease of cellular proliferation	DOID:14566	174	0.027
cancer	DOID:162	167	0.021
immune system disease	DOID:2914	155	0.015
carbohydrate metabolic disorder	DOID:2978	55	0.012

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