IMP: Integrative Multi-species Prediction

Homo sapiens

5 known processes

GCDH

glutaryl-CoA dehydrogenase

(Aliases: ACAD5,GCD)

HGNC: 4189
MIM: 608801
Entrez: 2639
HPRD: 01977
Ensembl: ENSG00000105607
UniProtKB: Q92947
UniProtKB: A0A024R7F9

Process Predictions
Disease Predictions

GCDH biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
cellular amino acid metabolic process	GO:0006520	116	0.752
small molecule catabolic process	GO:0044282	92	0.453
carboxylic acid catabolic process	GO:0046395	71	0.411
cellular amino acid catabolic process	GO:0009063	31	0.381
oxidation reduction process	GO:0055114	396	0.358
glutamine family amino acid metabolic process	GO:0009064	17	0.203
organic acid catabolic process	GO:0016054	71	0.195
mitochondrion organization	GO:0007005	156	0.179
alpha amino acid catabolic process	GO:1901606	26	0.174
single organism carbohydrate metabolic process	GO:0044723	193	0.148
monocarboxylic acid metabolic process	GO:0032787	185	0.116
response to abiotic stimulus	GO:0009628	336	0.107
organic hydroxy compound metabolic process	GO:1901615	147	0.091
protein oligomerization	GO:0051259	173	0.075
coenzyme metabolic process	GO:0006732	65	0.071
alpha amino acid metabolic process	GO:1901605	72	0.071
amine metabolic process	GO:0009308	44	0.069
cofactor metabolic process	GO:0051186	87	0.066
fatty acid metabolic process	GO:0006631	115	0.062
carbohydrate metabolic process	GO:0005975	207	0.061
cellular ketone metabolic process	GO:0042180	80	0.058
cellular macromolecule catabolic process	GO:0044265	380	0.058
system process	GO:0003008	349	0.055
response to oxygen containing compound	GO:1901700	369	0.055
small molecule biosynthetic process	GO:0044283	157	0.050
protein homooligomerization	GO:0051260	100	0.049
protein catabolic process	GO:0030163	325	0.049
regulation of cellular amino acid metabolic process	GO:0006521	6	0.048
response to hypoxia	GO:0001666	96	0.047
post embryonic development	GO:0009791	2	0.046
response to lipid	GO:0033993	206	0.044
cellular protein complex assembly	GO:0043623	188	0.044
mitochondrial rna metabolic process	GO:0000959	15	0.043
posttranscriptional regulation of gene expression	GO:0010608	213	0.042
protein localization to mitochondrion	GO:0070585	25	0.041
organonitrogen compound biosynthetic process	GO:1901566	200	0.041
cellular lipid metabolic process	GO:0044255	303	0.041
translation	GO:0006412	132	0.040
positive regulation of hydrolase activity	GO:0051345	331	0.038
secretion	GO:0046903	254	0.038
organic acid biosynthetic process	GO:0016053	97	0.038
steroid metabolic process	GO:0008202	94	0.036
sulfate transmembrane transport	GO:1902358	3	0.033
cellular response to dna damage stimulus	GO:0006974	379	0.033
alcohol metabolic process	GO:0006066	114	0.033
mitochondrial respiratory chain complex assembly	GO:0033108	23	0.032
response to axon injury	GO:0048678	1	0.032
response to organic cyclic compound	GO:0014070	204	0.032
lipid biosynthetic process	GO:0008610	177	0.030
regulation of endopeptidase activity	GO:0052548	170	0.030
regulation of oxidoreductase activity	GO:0051341	43	0.030
regulation of apoptotic signaling pathway	GO:2001233	175	0.029
cellular amine metabolic process	GO:0044106	41	0.028
dicarboxylic acid metabolic process	GO:0043648	29	0.028
branched chain amino acid catabolic process	GO:0009083	4	0.028
regulation of proteolysis	GO:0030162	293	0.027
positive regulation of cell death	GO:0010942	263	0.027
organophosphate catabolic process	GO:0046434	430	0.026
cellular response to oxidative stress	GO:0034599	85	0.026
proteolysis involved in cellular protein catabolic process	GO:0051603	244	0.026
cellular amino acid biosynthetic process	GO:0008652	30	0.026
protein processing	GO:0016485	226	0.026
purine containing compound catabolic process	GO:0072523	411	0.025
single organism cellular localization	GO:1902580	332	0.025
response to organonitrogen compound	GO:0010243	156	0.025
regulation of cellular ketone metabolic process	GO:0010565	50	0.025
protein import	GO:0017038	130	0.024
purine ribonucleotide biosynthetic process	GO:0009152	79	0.024
response to hormone	GO:0009725	175	0.024
positive regulation of programmed cell death	GO:0043068	249	0.023
response to cytokine	GO:0034097	232	0.023
lipid modification	GO:0030258	84	0.023
response to nitrogen compound	GO:1901698	184	0.022
ribonucleotide catabolic process	GO:0009261	405	0.022
secretion by cell	GO:0032940	226	0.022
negative regulation of protein kinase activity	GO:0006469	98	0.022
positive regulation of developmental process	GO:0051094	314	0.022
oxidoreduction coenzyme metabolic process	GO:0006733	19	0.022
regulation of transferase activity	GO:0051338	355	0.022
response to wounding	GO:0009611	168	0.021
negative regulation of protein metabolic process	GO:0051248	391	0.021
positive regulation of apoptotic process	GO:0043065	246	0.021
response to oxidative stress	GO:0006979	121	0.021
nucleotide biosynthetic process	GO:0009165	109	0.021
lipid metabolic process	GO:0006629	381	0.021
carboxylic acid transport	GO:0046942	63	0.021
cellular response to cytokine stimulus	GO:0071345	181	0.021
intracellular protein transport	GO:0006886	270	0.020
dna repair	GO:0006281	198	0.020
response to peptide	GO:1901652	65	0.020
regulation of immune response	GO:0050776	201	0.020
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	116	0.020
ncrna metabolic process	GO:0034660	108	0.020
regulation of protein kinase activity	GO:0045859	289	0.019
carboxylic acid biosynthetic process	GO:0046394	97	0.019
positive regulation of purine nucleotide biosynthetic process	GO:1900373	38	0.019
regulation of peptidase activity	GO:0052547	180	0.018
chemical homeostasis	GO:0048878	306	0.018
negative regulation of cell death	GO:0060548	345	0.018
mitochondrial transport	GO:0006839	60	0.018
negative regulation of cellular protein metabolic process	GO:0032269	353	0.018
positive regulation of proteolysis	GO:0045862	142	0.018
spermatid differentiation	GO:0048515	4	0.018
response to oxygen levels	GO:0070482	100	0.018
negative regulation of intracellular signal transduction	GO:1902532	183	0.017
negative regulation of catalytic activity	GO:0043086	335	0.017
regulation of cell growth	GO:0001558	135	0.017
regulation of kinase activity	GO:0043549	314	0.017
ion transmembrane transport	GO:0034220	338	0.017
regulation of protein processing	GO:0070613	150	0.017
cellular macromolecular complex assembly	GO:0034622	324	0.017
apoptotic signaling pathway	GO:0097190	268	0.017
regulation of defense response	GO:0031347	154	0.017
positive regulation of cyclic nucleotide biosynthetic process	GO:0030804	38	0.017
purine nucleoside triphosphate catabolic process	GO:0009146	392	0.017
immune response	GO:0006955	307	0.017
positive regulation of catabolic process	GO:0009896	310	0.017
negative regulation of transferase activity	GO:0051348	124	0.016
purine ribonucleotide catabolic process	GO:0009154	404	0.016
lipid catabolic process	GO:0016042	84	0.016
organophosphate biosynthetic process	GO:0090407	163	0.016
protein homotetramerization	GO:0051289	28	0.016
regulation of cellular amine metabolic process	GO:0033238	11	0.016
positive regulation of purine nucleotide metabolic process	GO:1900544	227	0.016
nucleotide catabolic process	GO:0009166	408	0.016
protein localization to organelle	GO:0033365	280	0.016
oogenesis	GO:0048477	2	0.016
immune effector process	GO:0002252	159	0.016
response to hyperoxia	GO:0055093	4	0.016
protein maturation	GO:0051604	233	0.016
defense response	GO:0006952	315	0.016
mitochondrion distribution	GO:0048311	3	0.015
female gamete generation	GO:0007292	2	0.015
regulation of anatomical structure morphogenesis	GO:0022603	286	0.015
immune system development	GO:0002520	195	0.015
regulation of hormone levels	GO:0010817	125	0.015
alpha amino acid biosynthetic process	GO:1901607	23	0.015
negative regulation of developmental process	GO:0051093	247	0.015
regulation of purine nucleotide metabolic process	GO:1900542	264	0.015
carbohydrate derivative biosynthetic process	GO:1901137	207	0.015
amino acid activation	GO:0043038	12	0.015
positive regulation of cysteine type endopeptidase activity	GO:2001056	79	0.015
regulation of cysteine type endopeptidase activity	GO:2000116	127	0.015
regulation of response to external stimulus	GO:0032101	222	0.014
regulation of dna metabolic process	GO:0051052	153	0.014
ion homeostasis	GO:0050801	230	0.014
positive regulation of protein catabolic process	GO:0045732	75	0.014
negative regulation of multicellular organismal process	GO:0051241	317	0.014
reactive oxygen species biosynthetic process	GO:1903409	4	0.014
negative regulation of cellular component organization	GO:0051129	235	0.014
protein tetramerization	GO:0051262	47	0.014
cellular response to oxygen containing compound	GO:1901701	276	0.014
response to acid chemical	GO:0001101	66	0.014
negative regulation of kinase activity	GO:0033673	106	0.014
response to drug	GO:0042493	81	0.013
response to metal ion	GO:0010038	84	0.013
ribonucleoside catabolic process	GO:0042454	406	0.013
intrinsic apoptotic signaling pathway	GO:0097193	127	0.013
cytoplasmic transport	GO:0016482	379	0.013
protein localization to membrane	GO:0072657	160	0.013
regulation of multi organism process	GO:0043900	157	0.013
nucleic acid phosphodiester bond hydrolysis	GO:0090305	102	0.013
purine nucleotide catabolic process	GO:0006195	405	0.013
purine nucleoside catabolic process	GO:0006152	398	0.013
regulation of growth	GO:0040008	165	0.013
negative regulation of response to external stimulus	GO:0032102	83	0.013
regulation of cellular response to stress	GO:0080135	244	0.013
negative regulation of phosphorus metabolic process	GO:0010563	267	0.012
cell cell signaling	GO:0007267	155	0.012
cellular response to abiotic stimulus	GO:0071214	117	0.012
organelle assembly	GO:0070925	176	0.012
organic acid transport	GO:0015849	65	0.012
response to increased oxygen levels	GO:0036296	4	0.012
negative regulation of phosphorylation	GO:0042326	174	0.012
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.012
covalent chromatin modification	GO:0016569	254	0.012
ras protein signal transduction	GO:0007265	73	0.012
regulation of protein catabolic process	GO:0042176	155	0.012
negative regulation of programmed cell death	GO:0043069	321	0.012
regulation of blood coagulation	GO:0030193	42	0.012
cellular response to nitrogen compound	GO:1901699	144	0.011
hormone metabolic process	GO:0042445	61	0.011
spermatid development	GO:0007286	4	0.011
peptide transport	GO:0015833	74	0.011
positive regulation of killing of cells of other organism	GO:0051712	4	0.011
negative regulation of protein processing	GO:0010955	142	0.011
response to decreased oxygen levels	GO:0036293	96	0.011
cellular hormone metabolic process	GO:0034754	41	0.011
establishment of protein localization to organelle	GO:0072594	172	0.011
hematopoietic or lymphoid organ development	GO:0048534	186	0.011
dicarboxylic acid biosynthetic process	GO:0043650	4	0.011
reproductive process	GO:0022414	106	0.011
biological adhesion	GO:0022610	331	0.011
regulation of cgmp biosynthetic process	GO:0030826	4	0.011
reactive nitrogen species metabolic process	GO:2001057	3	0.011
negative regulation of phosphate metabolic process	GO:0045936	267	0.011
cellular chemical homeostasis	GO:0055082	180	0.011
locomotory behavior	GO:0007626	1	0.010
regulation of peptide transport	GO:0090087	62	0.010
regulation of protein maturation	GO:1903317	150	0.010
neuron death	GO:0070997	65	0.010
alcohol biosynthetic process	GO:0046165	52	0.010
transmembrane transport	GO:0055085	399	0.010
cellular response to organonitrogen compound	GO:0071417	124	0.010
protein targeting	GO:0006605	187	0.010

GCDH disease predictions

Disease	DO term ID	Size	Probability
inherited metabolic disorder	DOID:655	242	0.973
disease of metabolism	DOID:0014667	295	0.973
amino acid metabolic disorder	DOID:9252	50	0.320
neurodegenerative disease	DOID:1289	102	0.140
central nervous system disease	DOID:331	186	0.140
nervous system disease	DOID:863	431	0.140
essential hypertension	DOID:10825	8	0.072
artery disease	DOID:0050828	23	0.072
hypertension	DOID:10763	13	0.072
vascular disease	DOID:178	25	0.072
cardiovascular system disease	DOID:1287	106	0.072
immune system disease	DOID:2914	155	0.065
disease of mental health	DOID:150	70	0.027
cognitive disorder	DOID:1561	29	0.027
sensory system disease	DOID:0050155	203	0.022
eye and adnexa disease	DOID:1492	150	0.022
disease of cellular proliferation	DOID:14566	174	0.021
cancer	DOID:162	167	0.017
carbohydrate metabolic disorder	DOID:2978	55	0.016
eye disease	DOID:5614	149	0.014
organ system cancer	DOID:0050686	164	0.014
organic acidemia	DOID:0060159	14	0.012
alzheimer s disease	DOID:10652	16	0.011
tauopathy	DOID:680	16	0.011
dementia	DOID:1307	19	0.011
musculoskeletal system disease	DOID:17	223	0.010

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