Homo sapiens

133 known processes

FBP1

fructose-1,6-bisphosphatase 1

(Aliases: FBP)

FBP1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular amino acid metabolic processGO:00065201160.191
system processGO:00030083490.168
regulation of cellular ketone metabolic processGO:0010565500.157
nucleoside catabolic processGO:00091644080.154
response to oxygen containing compoundGO:19017003690.150
oxidation reduction processGO:00551143960.121
cellular amine metabolic processGO:0044106410.120
cellular ketone metabolic processGO:0042180800.119
amine metabolic processGO:0009308440.119
regulation of cellular amino acid metabolic processGO:000652160.110
regulation of cellular amine metabolic processGO:0033238110.108
immune responseGO:00069553070.098
response to hormoneGO:00097251750.091
response to organic cyclic compoundGO:00140702040.090
cellular lipid metabolic processGO:00442553030.083
lipid metabolic processGO:00066293810.082
regulation of cell differentiationGO:00455953930.082
monocarboxylic acid metabolic processGO:00327871850.081
response to abiotic stimulusGO:00096283360.078
glycosyl compound catabolic processGO:19016584130.077
nucleoside phosphate catabolic processGO:19012924120.076
positive regulation of developmental processGO:00510943140.074
positive regulation of catabolic processGO:00098963100.071
positive regulation of transportGO:00510503360.071
ribonucleotide catabolic processGO:00092614050.070
regulation of cellular component movementGO:00512703340.069
secretionGO:00469032540.069
nitrogen compound transportGO:00717051910.066
regulation of cell motilityGO:20001452990.066
cellular macromolecule catabolic processGO:00442653800.066
purine nucleoside catabolic processGO:00061523980.066
organic hydroxy compound transportGO:0015850630.065
response to organonitrogen compoundGO:00102431560.065
phototransduction visible lightGO:000760320.065
chemical homeostasisGO:00488783060.063
organophosphate catabolic processGO:00464344300.063
ribonucleoside triphosphate metabolic processGO:00091994120.062
purine containing compound catabolic processGO:00725234110.062
response to cytokineGO:00340972320.061
carbohydrate metabolic processGO:00059752070.061
ribonucleoside catabolic processGO:00424544060.060
response to biotic stimulusGO:00096072760.059
anion transportGO:00068201610.059
positive regulation of cellular amino acid metabolic processGO:004576430.059
purine nucleoside triphosphate catabolic processGO:00091463920.058
locomotory behaviorGO:000762610.058
rhodopsin mediated signaling pathwayGO:001605610.058
cellular response to oxygen containing compoundGO:19017012760.058
positive regulation of phosphorylationGO:00423273940.058
positive regulation of transferase activityGO:00513472270.057
positive regulation of secretion by cellGO:19035321080.057
negative regulation of cellular protein metabolic processGO:00322693530.056
positive regulation of cellular amine metabolic processGO:003324070.056
positive regulation of cellular component organizationGO:00511303760.055
anatomical structure formation involved in morphogenesisGO:00486462840.055
positive regulation of cell motilityGO:20001471770.053
response to external biotic stimulusGO:00432072610.053
ion homeostasisGO:00508012300.052
cellular component morphogenesisGO:00329893140.052
response to nitrogen compoundGO:19016981840.052
response to other organismGO:00517072610.052
negative regulation of cell deathGO:00605483450.052
neurological system processGO:00508771630.051
regulation of cellular component biogenesisGO:00440872810.050
purine ribonucleoside triphosphate catabolic processGO:00092073910.050
response to lipidGO:00339932060.050
organic anion transportGO:00157111030.049
purine ribonucleoside metabolic processGO:00461284370.049
nucleoside triphosphate metabolic processGO:00091414220.049
cellular response to endogenous stimulusGO:00714953360.048
regulation of cell migrationGO:00303342890.048
regulation of immune responseGO:00507762010.048
secretion by cellGO:00329402260.048
small molecule biosynthetic processGO:00442831570.048
defense responseGO:00069523150.046
cellular macromolecular complex assemblyGO:00346223240.045
cation transportGO:00068123310.044
positive regulation of locomotionGO:00400171860.044
nucleotide catabolic processGO:00091664080.044
response to inorganic substanceGO:00100351270.044
innate immune responseGO:00450871780.044
regulation of locomotionGO:00400123290.043
organic acid biosynthetic processGO:0016053970.043
regulation of transferase activityGO:00513383550.043
positive regulation of immune system processGO:00026842830.043
ribonucleoside triphosphate catabolic processGO:00092033910.042
protein homooligomerizationGO:00512601000.042
regulation of protein localizationGO:00328802960.042
purine ribonucleoside catabolic processGO:00461303980.042
regulation of kinase activityGO:00435493140.042
negative regulation of multicellular organismal processGO:00512413170.042
purine ribonucleotide catabolic processGO:00091544040.042
cellular protein catabolic processGO:00442572610.041
purine nucleoside triphosphate metabolic processGO:00091444120.041
purine ribonucleoside triphosphate metabolic processGO:00092054110.041
regulation of anatomical structure morphogenesisGO:00226032860.041
enzyme linked receptor protein signaling pathwayGO:00071673030.040
cell morphogenesisGO:00009022960.040
post embryonic developmentGO:000979120.040
positive regulation of hydrolase activityGO:00513453310.040
nucleoside triphosphate catabolic processGO:00091433940.040
positive regulation of cellular catabolic processGO:00313312840.039
rhythmic behaviorGO:000762220.039
regulation of establishment of protein localizationGO:00702012420.039
positive regulation of cell migrationGO:00303351720.039
phototransductionGO:000760230.039
negative regulation of cellular component organizationGO:00511292350.039
single organism cellular localizationGO:19025803320.038
regulation of cytokine productionGO:00018172320.038
positive regulation of cell deathGO:00109422630.037
cellular homeostasisGO:00197251960.037
purine nucleotide catabolic processGO:00061954050.037
regulation of rhodopsin mediated signaling pathwayGO:002240010.037
biological adhesionGO:00226103310.037
positive regulation of cellular component movementGO:00512721810.036
positive regulation of cell differentiationGO:00455972110.036
circulatory system processGO:00030131130.036
negative regulation of apoptotic processGO:00430663160.036
cardiovascular system developmentGO:00723582620.036
apoptotic signaling pathwayGO:00971902680.035
neurotransmitter secretionGO:000726940.035
detection of stimulusGO:0051606850.035
positive regulation of programmed cell deathGO:00430682490.034
regulation of proteolysisGO:00301622930.034
cation homeostasisGO:00550801890.034
regulation of response to external stimulusGO:00321012220.034
circulatory system developmentGO:00723592620.034
single organism membrane organizationGO:00448022680.034
lipid biosynthetic processGO:00086101770.033
carboxylic acid transportGO:0046942630.033
positive regulation of protein kinase activityGO:00458601900.033
modification dependent protein catabolic processGO:00199412090.033
sensory perceptionGO:00076001030.033
positive regulation of organelle organizationGO:00106381950.033
positive regulation of kinase activityGO:00336742040.033
spermatid differentiationGO:004851540.033
negative regulation of phosphorus metabolic processGO:00105632670.032
negative regulation of phosphate metabolic processGO:00459362670.032
negative regulation of programmed cell deathGO:00430693210.032
carboxylic acid biosynthetic processGO:0046394970.032
cell developmentGO:00484683280.032
g protein coupled receptor signaling pathwayGO:00071862070.032
positive regulation of apoptotic processGO:00430652460.031
response to oxidative stressGO:00069791210.031
protein oligomerizationGO:00512591730.031
metal ion homeostasisGO:00550651690.031
cell projection organizationGO:00300302520.031
negative regulation of immune system processGO:00026831360.031
single organism carbohydrate metabolic processGO:00447231930.031
morphogenesis of embryonic epitheliumGO:001633140.031
signal transduction by phosphorylationGO:00230142970.030
membrane organizationGO:00610242920.030
regulation of apoptotic signaling pathwayGO:20012331750.030
salivary gland morphogenesisGO:000743540.030
nervous system developmentGO:00073992930.030
cell adhesionGO:00071553250.030
protein ubiquitinationGO:00165673140.030
cellular ion homeostasisGO:00068731680.030
atp catabolic processGO:00062001570.029
positive regulation of cellular component biogenesisGO:00440891580.029
peptidyl tyrosine modificationGO:00182121700.029
microtubule based processGO:00070172100.029
regulation of protein kinase activityGO:00458592890.028
vesicle mediated transportGO:00161923710.028
cellular metal ion homeostasisGO:00068751460.028
cytoplasmic transportGO:00164823790.028
regulation of cellular response to stressGO:00801352440.028
fatty acid metabolic processGO:00066311150.028
protein processingGO:00164852260.028
multicellular organismal agingGO:001025930.027
positive regulation of protein transportGO:00512221350.027
negative regulation of cellular amino acid metabolic processGO:004576320.027
oogenesisGO:004847720.027
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.027
memoryGO:000761330.026
rho protein signal transductionGO:0007266260.026
organelle assemblyGO:00709251760.026
protein acylationGO:00435431380.026
peptidyl tyrosine phosphorylationGO:00181081700.026
hemopoiesisGO:00300971800.026
positive regulation of secretionGO:00510471160.026
neuromuscular junction developmentGO:000752830.026
microtubule cytoskeleton organizationGO:00002261760.026
proteolysis involved in cellular protein catabolic processGO:00516032440.026
female gamete generationGO:000729220.026
response to alcoholGO:0097305640.026
cell projection assemblyGO:00300311260.025
regulation of hormone levelsGO:00108171250.025
protein catabolic processGO:00301633250.025
positive regulation of protein phosphorylationGO:00019343130.025
spermatid developmentGO:000728640.025
regulation of secretionGO:00510461940.025
dephosphorylationGO:00163112090.025
determination of adult lifespanGO:000834020.025
response to bacteriumGO:00096171440.025
nucleoside monophosphate metabolic processGO:00091231910.025
negative regulation of protein maturationGO:19033181420.025
cellular response to external stimulusGO:00714961110.025
epithelium developmentGO:00604292270.025
cellular protein complex assemblyGO:00436231880.025
protein localization to membraneGO:00726571600.024
small gtpase mediated signal transductionGO:0007264780.024
heart formationGO:006091420.024
activation of immune responseGO:00022531140.024
gtp catabolic processGO:00061842370.024
blood circulationGO:00080151130.024
regulation of peptidyl tyrosine phosphorylationGO:00507301080.024
reactive oxygen species metabolic processGO:0072593750.024
cellular response to cytokine stimulusGO:00713451810.024
negative regulation of protein metabolic processGO:00512483910.024
cellular lipid catabolic processGO:0044242650.024
nucleoside monophosphate catabolic processGO:00091251590.023
regulation of neural precursor cell proliferationGO:200017740.023
regulation of cell morphogenesisGO:00226041530.023
mapk cascadeGO:00001652880.023
growthGO:00400072020.023
cell activationGO:00017752130.023
negative regulation of catalytic activityGO:00430863350.023
guanosine containing compound catabolic processGO:19010692390.023
neuron differentiationGO:00301821380.023
modification dependent macromolecule catabolic processGO:00436322120.023
glycoprotein metabolic processGO:00091001100.023
myeloid cell differentiationGO:00300991170.023
response to woundingGO:00096111680.023
response to steroid hormoneGO:0048545800.023
cellular chemical homeostasisGO:00550821800.023
cytokine productionGO:00018162470.023
organic hydroxy compound metabolic processGO:19016151470.023
protein modification by small protein conjugationGO:00324463420.022
cellular response to organonitrogen compoundGO:00714171240.022
response to molecule of bacterial originGO:0002237820.022
positive regulation of apoptotic signaling pathwayGO:2001235700.022
reactive nitrogen species metabolic processGO:200105730.022
sulfur compound metabolic processGO:00067901010.022
forebrain generation of neuronsGO:002187230.022
regulation of erk1 and erk2 cascadeGO:0070372990.022
negative regulation of protein modification processGO:00314002000.022
tachykinin receptor signaling pathwayGO:000721730.022
positive regulation of cytokine productionGO:00018191670.022
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.022
regulation of cell developmentGO:00602841610.022
immune system developmentGO:00025201950.022
alcohol metabolic processGO:00060661140.022
regulation of cell activationGO:00508651250.022
protein maturationGO:00516042330.022
divalent inorganic cation transportGO:00725111580.022
neuroblast proliferationGO:000740540.022
cellular modified amino acid metabolic processGO:0006575640.021
negative regulation of phosphorylationGO:00423261740.021
cilium morphogenesisGO:0060271750.021
divalent metal ion transportGO:00708381520.021
immune response regulating signaling pathwayGO:0002764970.021
purine nucleoside monophosphate catabolic processGO:00091281580.021
regulation of response to woundingGO:19030341010.021
regulation of leukocyte activationGO:00026941150.021
regulation of mitochondrion organizationGO:0010821540.021
positive regulation of protein secretionGO:0050714600.021
negative regulation of cell proliferationGO:00082852280.021
cellular response to organic cyclic compoundGO:00714071270.021
transmembrane transportGO:00550853990.021
carbohydrate derivative biosynthetic processGO:19011372070.021
regulation of growthGO:00400081650.021
neurogenesisGO:00220081690.020
thymus developmentGO:004853830.020
cellular cation homeostasisGO:00300031630.020
negative regulation of b cell receptor signaling pathwayGO:005085920.020
ribonucleoside monophosphate metabolic processGO:00091611870.020
regulation of secretion by cellGO:19035301770.020
regulation of epithelial cell migrationGO:0010632930.020
circadian behaviorGO:004851220.020
negative regulation of cellular amine metabolic processGO:003323930.020
response to metal ionGO:0010038840.020
mitochondrion organizationGO:00070051560.020
neural tube patterningGO:002153220.020
photoreceptor cell differentiationGO:004653020.020
regulation of cell adhesionGO:00301551660.020
small molecule catabolic processGO:0044282920.020
hematopoietic or lymphoid organ developmentGO:00485341860.020
cellular response to nitrogen compoundGO:19016991440.020
glycerolipid metabolic processGO:00464861070.020
positive regulation of immune responseGO:00507781590.020
regulation of cell projection organizationGO:00313441070.020
ubiquitin dependent protein catabolic processGO:00065112060.020
cellular response to growth factor stimulusGO:00713631970.020
jnk cascadeGO:0007254800.019
reactive oxygen species biosynthetic processGO:190340940.019
lipid transportGO:0006869900.019
organic acid transportGO:0015849650.019
adult locomotory behaviorGO:000834410.019
intracellular protein transportGO:00068862700.019
regulation of mapk cascadeGO:00434082620.019
positive regulation of protein complex assemblyGO:0031334860.019
regulation of stress activated protein kinase signaling cascadeGO:0070302850.019
cilium organizationGO:0044782680.019
purine ribonucleoside monophosphate metabolic processGO:00091671860.019
signal releaseGO:0023061700.019
regulation of protein complex assemblyGO:00432541470.019
gtp metabolic processGO:00460392390.019
immune response activating signal transductionGO:0002757900.019
nerve developmentGO:002167540.019
regulation of body fluid levelsGO:0050878990.019
leukocyte activationGO:00453211640.018
purine nucleoside monophosphate metabolic processGO:00091261860.018
organelle localizationGO:0051640840.018
segmentationGO:003528240.018
ribonucleoside monophosphate catabolic processGO:00091581580.018
regulation of system processGO:00440571010.018
lipid modificationGO:0030258840.018
regulation of protein transportGO:00512232130.018
mitotic cell cycleGO:00002783260.018
maintenance of locationGO:00512351120.018
atp metabolic processGO:00460341760.018
blood vessel developmentGO:00015681720.018
positive regulation of purine nucleotide catabolic processGO:00331231850.018
regulation of protein secretionGO:0050708860.018
response to growth factorGO:00708482050.018
detection of chemical stimulus involved in sensory perceptionGO:0050907330.018
metal ion transportGO:00300012720.018
negative regulation of cell migrationGO:00303361020.018
actin filament based processGO:00300292240.018
angiogenesisGO:00015251470.018
regenerationGO:003109940.018
pituitary gland developmentGO:002198320.017
sensory perception of smellGO:000760820.017
cytokine mediated signaling pathwayGO:00192211090.017
positive regulation of proteolysisGO:00458621420.017
response to oxygen levelsGO:00704821000.017
oocyte differentiationGO:000999420.017
cilium assemblyGO:0042384630.017
regulation of vesicle mediated transportGO:00606271300.017
positive regulation of cell developmentGO:0010720920.017
tissue homeostasisGO:0001894630.017
immune effector processGO:00022521590.017
positive regulation of response to external stimulusGO:0032103880.017
regulation of sequence specific dna binding transcription factor activityGO:00510902110.017
endomembrane system organizationGO:00102561960.017
inner ear morphogenesisGO:004247240.017
ras protein signal transductionGO:0007265730.017
regulation of protein maturationGO:19033171500.017
receptor metabolic processGO:0043112810.017
regulation of t cell activationGO:0050863770.017
generation of neuronsGO:00486991520.017
cellular divalent inorganic cation homeostasisGO:00725031280.017
protein secretionGO:0009306980.017
t cell activationGO:0042110990.017
cofactor metabolic processGO:0051186870.017
organonitrogen compound biosynthetic processGO:19015662000.017
oocyte developmentGO:004859910.017
negative regulation of protein phosphorylationGO:00019331400.017
protein acetylationGO:00064731160.017
regulation of reactive oxygen species biosynthetic processGO:190342630.017
response to decreased oxygen levelsGO:0036293960.016
positive regulation of cell proliferationGO:00082843010.016
cell cell junction organizationGO:0045216690.016
regulation of nucleoside metabolic processGO:00091182090.016
posttranscriptional regulation of gene expressionGO:00106082130.016
single organism cell adhesionGO:00986021790.016
anatomical structure homeostasisGO:00602491000.016
regulation of purine nucleotide catabolic processGO:00331212050.016
activation of protein kinase activityGO:0032147900.016
negative regulation of proteolysisGO:00458611320.016
extrinsic apoptotic signaling pathwayGO:00971911190.016
regulation of cell cycle processGO:00105642660.016
monocarboxylic acid biosynthetic processGO:0072330670.016
leukocyte migrationGO:00509001070.016
positive regulation of nucleotide metabolic processGO:00459812300.016
i kappab kinase nf kappab signalingGO:00072491660.016
lymphocyte activationGO:00466491330.016
negative regulation of apoptotic signaling pathwayGO:2001234970.016
inflammatory responseGO:0006954790.016
positive regulation of mapk cascadeGO:00434101900.016
cellular response to lipidGO:00713961270.016
regulation of eosinophil activationGO:190256620.016
protein localization to organelleGO:00333652800.016
negative regulation of intracellular signal transductionGO:19025321830.016
organ formationGO:004864530.016
blood vessel morphogenesisGO:00485141620.016
positive regulation of peptidyl tyrosine phosphorylationGO:0050731850.016
meiosis iGO:000712740.016
peptidyl lysine modificationGO:00182051440.016
positive regulation of purine nucleotide metabolic processGO:19005442270.016
regulation of protein processingGO:00706131500.016
embryonic placenta developmentGO:000189210.016
hindbrain developmentGO:003090230.016
alpha amino acid metabolic processGO:1901605720.015
positive regulation of erk1 and erk2 cascadeGO:0070374750.015
peripheral nervous system developmentGO:000742220.015
long term memoryGO:000761620.015
regulation of mononuclear cell proliferationGO:0032944650.015
vasculature developmentGO:00019441810.015
compound eye developmentGO:004874910.015
endodermal cell fate specificationGO:000171440.015
response to peptideGO:1901652650.015
head developmentGO:00603221080.015
regulation of cell cycleGO:00517263930.015
morphogenesis of a polarized epitheliumGO:000173830.015
response to salt stressGO:000965130.015
cell part morphogenesisGO:00329901370.015
regulation of purine nucleotide metabolic processGO:19005422640.015
lipid catabolic processGO:0016042840.015
epithelial cell migrationGO:00106311190.015
intrinsic apoptotic signaling pathwayGO:00971931270.015
glycoprotein biosynthetic processGO:0009101910.015
regulation of lymphocyte proliferationGO:0050670640.015
ameboidal type cell migrationGO:00016671350.015
cell projection morphogenesisGO:00488581290.015
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.015
cellular response to extracellular stimulusGO:0031668720.015
cellular response to hormone stimulusGO:00328701250.015
regulation of bindingGO:00510981110.015
circadian sleep wake cycle processGO:002241020.015
lipid localizationGO:00108761060.015
cellular response to dna damage stimulusGO:00069743790.015
regulation of gtp catabolic processGO:00331241800.014
regulation of intracellular transportGO:00323861950.014
regulation of peptidase activityGO:00525471800.014
cell substrate adhesionGO:00315891320.014
response to hypoxiaGO:0001666960.014
regulation of i kappab kinase nf kappab signalingGO:00431221620.014
response to acid chemicalGO:0001101660.014
organ morphogenesisGO:00098871470.014
regulation of rho protein signal transductionGO:0035023790.014
behaviorGO:00076101120.014
positive regulation of gliogenesisGO:001401540.014
divalent inorganic cation homeostasisGO:00725071360.014
sensory perception of painGO:001923340.014
steroid metabolic processGO:0008202940.014
cell fate determinationGO:000170930.014
response to cocaineGO:004222010.014
guanosine containing compound metabolic processGO:19010682440.014
organic acid catabolic processGO:0016054710.014
protein autophosphorylationGO:00467771230.014
astrocyte differentiationGO:004870840.014
regulation of immune effector processGO:0002697910.014
inorganic cation transmembrane transportGO:00986621940.014
immunoglobulin transcytosis in epithelial cellsGO:000241410.014
regulation of extrinsic apoptotic signaling pathwayGO:2001236850.014
cellular carbohydrate metabolic processGO:0044262840.014
positive regulation of synaptic transmissionGO:005080640.014
positive regulation of reactive oxygen species biosynthetic processGO:190342820.014
coenzyme metabolic processGO:0006732650.014
cellular response to oxidative stressGO:0034599850.014
negative regulation of locomotionGO:00400131180.014
regulation of nucleotide metabolic processGO:00061402690.014
cellular amide metabolic processGO:0043603690.014
purine ribonucleoside monophosphate catabolic processGO:00091691580.014
regulation of leukocyte proliferationGO:0070663670.014
positive regulation of gtp catabolic processGO:00331261660.014
embryo developmentGO:00097901230.014
eye photoreceptor cell differentiationGO:000175420.014
response to lipopolysaccharideGO:0032496700.014
detection of stimulus involved in sensory perceptionGO:0050906430.014
chromatin organizationGO:00063253510.014
positive regulation of cell activationGO:0050867810.014
cell growthGO:00160491600.014
defense response to other organismGO:00985421290.014
sequestering of calcium ionGO:0051208170.014
somitogenesisGO:000175620.014
response to fungusGO:000962040.014
cell cell signalingGO:00072671550.013
myeloid leukocyte differentiationGO:0002573600.013
regulation of protein modification by small protein conjugation or removalGO:19033201070.013
associative learningGO:000830610.013
response to reactive oxygen speciesGO:0000302610.013
generation of precursor metabolites and energyGO:0006091680.013
striated muscle contractionGO:0006941520.013
myeloid leukocyte migrationGO:0097529620.013
cell junction organizationGO:0034330790.013
positive regulation of nucleoside metabolic processGO:00459791860.013
carboxylic acid catabolic processGO:0046395710.013
meiotic chromosome segregationGO:004513240.013
negative regulation of developmental processGO:00510932470.013
hemostasisGO:0007599760.013
regulation of multi organism processGO:00439001570.013
histone modificationGO:00165702510.013
regulation of endopeptidase activityGO:00525481700.013
thyroid hormone transportGO:007032720.013
positive regulation of intracellular transportGO:00323881040.013

FBP1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.123
inherited metabolic disorderDOID:6552420.083
disease of cellular proliferationDOID:145661740.036
cancerDOID:1621670.036
amino acid metabolic disorderDOID:9252500.028
organ system cancerDOID:00506861640.026
immune system diseaseDOID:29141550.025
sensory system diseaseDOID:00501552030.023
nervous system diseaseDOID:8634310.023
central nervous system diseaseDOID:3311860.023
musculoskeletal system diseaseDOID:172230.018
eye and adnexa diseaseDOID:14921500.017
eye diseaseDOID:56141490.017
cardiovascular system diseaseDOID:12871060.016
gastrointestinal system cancerDOID:3119520.014
disease of mental healthDOID:150700.014