Homo sapiens

230 known processes

HLA-DRB1

major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1

(Aliases: FLJ76359,HLA-DRB,HLA-DRB1*,SS1,HLA-DR1B,DRw10,FLJ75017,DRB1)

HLA-DRB1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
dendritic cell antigen processing and presentationGO:000246811.000
peptide antigen assembly with mhc protein complexGO:000250141.000
antigen processing and presentation of peptide antigen via mhc class iiGO:0002495111.000
peptide antigen assembly with mhc class ii protein complexGO:000250341.000
polysaccharide assembly with mhc class ii protein complexGO:000250621.000
antigen processing and presentation of peptide antigenGO:0048002181.000
negative regulation of antigen processing and presentationGO:000257851.000
antigen processing and presentation of peptide or polysaccharide antigen via mhc class iiGO:0002504120.999
protein carbohydrate complex subunit organizationGO:007182320.999
antigen processing and presentationGO:0019882330.999
antigen processing and presentation of exogenous peptide antigen via mhc class iiGO:001988640.998
mhc protein complex assemblyGO:000239640.997
positive regulation of myeloid leukocyte cytokine production involved in immune responseGO:006108110.995
mhc class ii protein complex assemblyGO:000239940.994
regulation of antigen processing and presentation of peptide antigen via mhc class iiGO:000258630.994
de novo protein foldingGO:000645820.992
antigen processing and presentation of polysaccharide antigen via mhc class iiGO:000250520.992
regulation of interleukin 10 secretionGO:200117940.987
cellular response to ammonium ionGO:007124240.975
humoral immune responseGO:0006959490.968
regulation of t cell proliferationGO:0042129420.966
lymphocyte mediated immunityGO:0002449480.937
peptide transportGO:0015833740.935
lymphocyte proliferationGO:0046651700.916
positive regulation of insulin secretion involved in cellular response to glucose stimulusGO:003577430.909
negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via mhc class iiGO:000258130.909
positive regulation of lymphocyte proliferationGO:0050671460.908
regulation of cell activationGO:00508651250.894
positive regulation of leukocyte proliferationGO:0070665480.890
regulation of lymphocyte proliferationGO:0050670640.889
regulation of t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cellGO:200118820.886
cellular macromolecular complex assemblyGO:00346223240.882
leukocyte mediated immunityGO:0002443590.882
regulation of leukocyte proliferationGO:0070663670.868
cytokine productionGO:00018162470.868
antigen processing and presentation of exogenous peptide antigenGO:000247840.861
positive regulation of t cell activationGO:0050870540.836
regulation of defense responseGO:00313471540.831
cellular protein complex assemblyGO:00436231880.829
positive regulation of immune responseGO:00507781590.826
t helper 1 type immune responseGO:004208880.809
immune responseGO:00069553070.807
regulation of lymphocyte activationGO:00512491030.796
cellular homeostasisGO:00197251960.795
positive regulation of lymphocyte differentiationGO:0045621130.785
nitrogen compound transportGO:00717051910.778
positive regulation of lymphocyte activationGO:0051251730.771
negative regulation of response to external stimulusGO:0032102830.758
regulation of cytokine productionGO:00018172320.744
cell activationGO:00017752130.728
regulation of response to woundingGO:19030341010.716
peptide secretionGO:0002790510.707
leukocyte activationGO:00453211640.707
negative regulation of defense responseGO:0031348470.705
t cell activationGO:0042110990.704
signal releaseGO:0023061700.699
negative regulation of antigen processing and presentation of peptide antigen via mhc class iiGO:000258720.698
positive regulation of leukocyte activationGO:0002696800.697
regulation of t cell activationGO:0050863770.689
positive regulation of hormone secretionGO:0046887250.681
positive regulation of cell activationGO:0050867810.679
detection of other organismGO:0098543130.677
humoral immune response mediated by circulating immunoglobulinGO:000245550.672
negative regulation of antigen processing and presentation of peptide antigenGO:000258430.670
immunoglobulin mediated immune responseGO:0016064100.664
t cell selectionGO:004505840.660
regulation of interleukin 4 productionGO:003267370.653
secretionGO:00469032540.642
detection of external biotic stimulusGO:0098581190.640
positive regulation of leukocyte differentiationGO:1902107370.633
detection of biotic stimulusGO:0009595210.627
leukocyte proliferationGO:0070661740.621
lymphocyte activationGO:00466491330.610
regulation of immune responseGO:00507762010.610
positive regulation of cytokine productionGO:00018191670.588
positive regulation of peptide hormone secretionGO:0090277150.587
regulation of leukocyte activationGO:00026941150.581
response to hexoseGO:0009746200.580
hormone secretionGO:0046879650.567
cellular glucose homeostasisGO:0001678110.565
positive regulation of t cell differentiationGO:0045582110.559
positive regulation of adaptive immune responseGO:0002821210.549
cellular lipid metabolic processGO:00442553030.547
cellular response to interferon gammaGO:0071346240.542
regulation of insulin secretionGO:0050796330.532
innate immune responseGO:00450871780.527
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822290.505
regulation of interferon gamma productionGO:0032649360.504
cellular response to glucose stimulusGO:0071333100.502
defense responseGO:00069523150.490
positive thymic t cell selectionGO:004505910.484
positive regulation of immune system processGO:00026842830.483
regulation of protein transportGO:00512232130.482
thymic t cell selectionGO:004506120.465
mononuclear cell proliferationGO:0032943710.454
regulation of cell migrationGO:00303342890.453
interleukin 4 productionGO:003263370.416
positive regulation of secretionGO:00510471160.396
leukocyte differentiationGO:0002521980.389
inflammatory response to antigenic stimulusGO:000243740.388
detection of chemical stimulus involved in sensory perceptionGO:0050907330.379
regulation of chemotaxisGO:0050920740.356
regulation of antigen processing and presentationGO:000257760.349
negative regulation of immune system processGO:00026831360.341
positive regulation of insulin secretionGO:0032024100.339
hematopoietic or lymphoid organ developmentGO:00485341860.334
cellular response to oxygen containing compoundGO:19017012760.326
system processGO:00030083490.311
negative regulation of lymphocyte activationGO:0051250240.298
positive regulation of mononuclear cell proliferationGO:0032946470.298
response to fungusGO:000962040.291
positive regulation of t cell proliferationGO:0042102330.281
t cell proliferationGO:0042098450.268
b cell homeostasisGO:000178210.264
de novo posttranslational protein foldingGO:005108420.251
response to oxygen containing compoundGO:19017003690.242
regulation of antigen processing and presentation of peptide or polysaccharide antigen via mhc class iiGO:000258040.238
regulation of cell differentiationGO:00455953930.210
response to bacteriumGO:00096171440.210
hemopoiesisGO:00300971800.195
immune system developmentGO:00025201950.189
cytokine secretionGO:0050663640.185
positive regulation of protein kinase activityGO:00458601900.175
prostaglandin biosynthetic processGO:0001516110.169
interleukin 10 productionGO:0032613170.169
positive regulation of cell proliferationGO:00082843010.152
negative regulation of immune responseGO:0050777400.151
regulation of adaptive immune responseGO:0002819330.147
cellular amine metabolic processGO:0044106410.146
lymphocyte differentiationGO:0030098350.145
positive regulation of peptide secretionGO:0002793150.144
protein maturationGO:00516042330.142
unsaturated fatty acid biosynthetic processGO:0006636210.140
antigen processing and presentation of exogenous antigenGO:001988440.139
negative regulation of cell proliferationGO:00082852280.137
fibroblast proliferationGO:0048144330.132
protein oligomerizationGO:00512591730.128
cell projection organizationGO:00300302520.126
regulation of secretion by cellGO:19035301770.120
response to cytokineGO:00340972320.120
regulation of protein secretionGO:0050708860.118
negative regulation of t cell activationGO:0050868180.114
regulation of leukocyte differentiationGO:1902105610.110
neurological system processGO:00508771630.109
chaperone mediated protein foldingGO:0061077130.103
chaperone mediated protein folding requiring cofactorGO:005108510.102
positive regulation of developmental processGO:00510943140.101
chemokine c x c motif ligand 2 productionGO:007256730.098
protein secretionGO:0009306980.094
regulation of apoptotic signaling pathwayGO:20012331750.093
cytokine mediated signaling pathwayGO:00192211090.088
negative regulation of catalytic activityGO:00430863350.087
regulation of peptide hormone secretionGO:0090276410.087
regulation of cellular ketone metabolic processGO:0010565500.086
positive regulation of neutrophil chemotaxisGO:009002370.086
regulation of immune effector processGO:0002697910.084
regulation of hormone levelsGO:00108171250.083
positive regulation of cellular amine metabolic processGO:003324070.079
negative regulation of peptidase activityGO:0010466910.078
cellular response to cytokine stimulusGO:00713451810.076
t cell activation via t cell receptor contact with antigen bound to mhc molecule on antigen presenting cellGO:000229140.075
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002824190.074
intrinsic apoptotic signaling pathway by p53 class mediatorGO:0072332370.072
negative regulation of inflammatory response to antigenic stimulusGO:000286220.068
unsaturated fatty acid metabolic processGO:0033559370.067
immunoglobulin productionGO:0002377120.064
regulation of inflammatory responseGO:0050727460.064
negative regulation of lymphocyte apoptotic processGO:007022980.063
positive t cell selectionGO:004336820.063
cellular response to molecule of bacterial originGO:0071219620.061
response to external biotic stimulusGO:00432072610.059
fatty acid derivative metabolic processGO:1901568350.059
mapk cascadeGO:00001652880.058
detection of bacteriumGO:0016045130.058
leukocyte activation involved in immune responseGO:0002366300.058
cellular response to monosaccharide stimulusGO:0071326100.057
regulation of complement activation lectin pathwayGO:000186820.055
positive regulation of humoral immune responseGO:000292230.054
regulation of neutrophil migrationGO:1902622100.054
negative regulation of b cell apoptotic processGO:000290340.054
regulation of anatomical structure morphogenesisGO:00226032860.051
negative regulation of cell activationGO:0050866330.051
hormone transportGO:0009914680.051
secretion by cellGO:00329402260.050
taxisGO:00423301570.050
regulation of secretionGO:00510461940.049
negative regulation of cell differentiationGO:00455961710.049
positive regulation of t helper 1 type immune responseGO:000282740.049
cellular amino acid metabolic processGO:00065201160.046
actin filament based processGO:00300292240.045
amine metabolic processGO:0009308440.045
amide transportGO:0042886760.045
b cell mediated immunityGO:0019724100.044
t cell activation involved in immune responseGO:0002286130.043
insulin secretionGO:0030073390.042
positive regulation of transportGO:00510503360.041
glucose homeostasisGO:0042593310.041
post embryonic developmentGO:000979120.040
regulation of kinase activityGO:00435493140.040
intrinsic apoptotic signaling pathwayGO:00971931270.039
monocarboxylic acid biosynthetic processGO:0072330670.039
regulation of establishment of protein localizationGO:00702012420.039
negative regulation of hydrolase activityGO:00513461820.038
positive regulation of kinase activityGO:00336742040.037
posttranscriptional regulation of gene expressionGO:00106082130.037
positive regulation of secretion by cellGO:19035321080.036
regulation of peptidase activityGO:00525471800.036
positive regulation of peptidyl tyrosine phosphorylationGO:0050731850.035
regulation of leukocyte chemotaxisGO:0002688460.035
positive regulation of cell migrationGO:00303351720.034
regulation of protein localizationGO:00328802960.033
protein tetramerizationGO:0051262470.033
negative regulation of multicellular organismal processGO:00512413170.033
positive regulation of phosphorylationGO:00423273940.032
peptide hormone secretionGO:0030072500.032
sensory perception of chemical stimulusGO:0007606380.032
regulation of lymphocyte differentiationGO:0045619220.032
response to corticosteroidGO:0031960150.032
positive regulation of response to external stimulusGO:0032103880.032
chemical homeostasisGO:00488783060.031
receptor metabolic processGO:0043112810.031
response to carbohydrateGO:0009743210.031
negative regulation of t cell proliferationGO:004213080.030
negative regulation of apoptotic processGO:00430663160.029
positive regulation of cellular amino acid metabolic processGO:004576430.029
regulation of cellular amine metabolic processGO:0033238110.029
regulation of protein kinase activityGO:00458592890.029
t cell differentiation in thymusGO:003307740.029
regulation of proteolysisGO:00301622930.028
negative regulation of cytolysisGO:004591830.028
azole transportGO:004511740.028
response to organic cyclic compoundGO:00140702040.027
regulation of cell motilityGO:20001452990.027
positive regulation of production of molecular mediator of immune responseGO:0002702110.027
negative regulation of cellular component organizationGO:00511292350.027
regulation of inflammatory response to antigenic stimulusGO:000286120.027
prostanoid biosynthetic processGO:0046457110.027
response to biotic stimulusGO:00096072760.027
negative regulation of cellular protein metabolic processGO:00322693530.026
fatty acid derivative biosynthetic processGO:1901570180.026
cation transportGO:00068123310.025
negative regulation of leukocyte proliferationGO:0070664160.025
negative regulation of cell deathGO:00605483450.025
response to other organismGO:00517072610.024
symbiosis encompassing mutualism through parasitismGO:00444031560.024
endocytosisGO:00068971590.023
carbohydrate homeostasisGO:0033500310.023
multicellular organismal agingGO:001025930.023
negative regulation of leukocyte differentiationGO:1902106240.023
regulation of transferase activityGO:00513383550.023
positive regulation of cell deathGO:00109422630.023
regulation of mononuclear cell proliferationGO:0032944650.023
response to interferon gammaGO:0034341390.023
interspecies interaction between organismsGO:00444191560.023
production of molecular mediator of immune responseGO:0002440370.022
negative regulation of apoptotic signaling pathwayGO:2001234970.022
cognitionGO:0050890430.022
cellular cation homeostasisGO:00300031630.021
negative regulation of programmed cell deathGO:00430693210.021
cell type specific apoptotic processGO:00972851250.021
protein ubiquitinationGO:00165673140.021
positive regulation of protein serine threonine kinase activityGO:00719021190.021
protein processingGO:00164852260.021
nucleoside triphosphate catabolic processGO:00091433940.021
cellular response to dna damage stimulusGO:00069743790.021
regulation of cellular component movementGO:00512703340.020
immune effector processGO:00022521590.020
cell cell signalingGO:00072671550.019
regulation of cell developmentGO:00602841610.019
regulation of peptide secretionGO:0002791420.019
signal transduction by phosphorylationGO:00230142970.019
negative regulation of leukocyte activationGO:0002695260.019
positive regulation of locomotionGO:00400171860.019
inositol lipid mediated signalingGO:0048017550.019
lipid metabolic processGO:00066293810.018
protein modification by small protein conjugationGO:00324463420.018
generation of neuronsGO:00486991520.018
positive regulation of cell differentiationGO:00455972110.018
negative regulation of protein metabolic processGO:00512483910.018
t cell differentiationGO:0030217290.018
biological adhesionGO:00226103310.018
response to molecule of bacterial originGO:0002237820.017
leukocyte migrationGO:00509001070.017
ras protein signal transductionGO:0007265730.017
positive regulation of transferase activityGO:00513472270.017
sensory organ developmentGO:0007423520.017
positive regulation of b cell activationGO:0050871170.017
regulation of humoral immune responseGO:0002920110.017
purine ribonucleoside triphosphate metabolic processGO:00092054110.017
cell adhesionGO:00071553250.017
response to woundingGO:00096111680.017
cell developmentGO:00484683280.017
cellular chemical homeostasisGO:00550821800.017
positive regulation of ion transportGO:0043270870.017
regulation of locomotionGO:00400123290.016
negative regulation of response to woundingGO:1903035470.016
negative regulation of locomotionGO:00400131180.016
negative regulation of phosphorus metabolic processGO:00105632670.016
regulation of cellular response to stressGO:00801352440.016
regulation of protein stabilityGO:0031647870.016
negative regulation of chemotaxisGO:0050922130.016
negative regulation of proteolysisGO:00458611320.016
cellular response to oxidative stressGO:0034599850.016
positive regulation of cellular component organizationGO:00511303760.015
regulation of cytokine secretionGO:0050707570.015
negative regulation of transportGO:00510511760.015
regulation of endopeptidase activityGO:00525481700.015
carbohydrate metabolic processGO:00059752070.015
b cell proliferationGO:0042100220.015
oogenesisGO:004847720.015
regulation of gtpase activityGO:00430871800.014
regulation of antigen processing and presentation of peptide antigenGO:000258340.014
regulation of protein maturationGO:19033171500.014
ameboidal type cell migrationGO:00016671350.014
negative regulation of intracellular signal transductionGO:19025321830.014
positive regulation of cell motilityGO:20001471770.014
regulation of vesicle mediated transportGO:00606271300.014
determination of adult lifespanGO:000834020.014
response to dexamethasoneGO:007154810.014
intracellular protein transportGO:00068862700.014
regulation of protein processingGO:00706131500.014
response to glucoseGO:0009749190.014
detection of stimulusGO:0051606850.014
cellular response to dexamethasone stimulusGO:007154910.014
purine ribonucleoside catabolic processGO:00461303980.014
regulation of protein serine threonine kinase activityGO:00719001790.014
negative regulation of protein maturationGO:19033181420.013
monocarboxylic acid metabolic processGO:00327871850.013
apoptotic signaling pathwayGO:00971902680.013
tissue homeostasisGO:0001894630.013
regulation of b cell proliferationGO:0030888180.013
positive regulation of immune effector processGO:0002699400.013
detection of chemical stimulusGO:0009593550.013
small gtpase mediated signal transductionGO:0007264780.013
mitotic cell cycle phase transitionGO:00447721620.013
purine ribonucleoside metabolic processGO:00461284370.013
negative regulation of inflammatory responseGO:0050728220.013
growthGO:00400072020.013
regulation of cytoskeleton organizationGO:00514931770.013
negative regulation of cell cycleGO:00457861930.012
protein catabolic processGO:00301633250.012
regulation of intracellular transport of viral materialGO:190125220.012
negative regulation of cellular catabolic processGO:0031330830.012
nervous system developmentGO:00073992930.012
regulation of acute inflammatory response to antigenic stimulusGO:000286410.012
regulation of cell projection organizationGO:00313441070.012
cellular protein catabolic processGO:00442572610.012
cell activation involved in immune responseGO:0002263300.012
protein foldingGO:0006457380.012
cellular response to glucocorticoid stimulusGO:007138540.012
adaptive immune responseGO:0002250490.012
regulation of transmembrane transportGO:00347621390.011
purine containing compound catabolic processGO:00725234110.011
organic acid biosynthetic processGO:0016053970.011
mitotic cell cycleGO:00002783260.011
regulation of t cell differentiationGO:0045580190.011
negative regulation of phosphate metabolic processGO:00459362670.011
regulation of peptide transportGO:0090087620.011
cell growthGO:00160491600.011
nucleoside phosphate catabolic processGO:19012924120.011
positive regulation of programmed cell deathGO:00430682490.011
regulation of syncytium formation by plasma membrane fusionGO:006014220.011
vesicle mediated transportGO:00161923710.011
negative regulation of protein processingGO:00109551420.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002460400.011
positive regulation of homeostatic processGO:0032846470.011
regulation of intracellular protein transportGO:00331571230.011
cellular response to nitrogen compoundGO:19016991440.011
sprouting angiogenesisGO:0002040290.011
negative regulation of cellular component movementGO:00512711060.011
positive regulation of b cell proliferationGO:0030890120.011
small molecule biosynthetic processGO:00442831570.011
organelle assemblyGO:00709251760.010
positive regulation of apoptotic signaling pathwayGO:2001235700.010
modification dependent protein catabolic processGO:00199412090.010
cellular response to endogenous stimulusGO:00714953360.010
transmission of nerve impulseGO:0019226110.010
interferon gamma productionGO:0032609390.010
regulation of innate immune responseGO:0045088970.010
guanosine containing compound catabolic processGO:19010692390.010
lymphocyte homeostasisGO:000226040.010
anatomical structure formation involved in morphogenesisGO:00486462840.010
reactive oxygen species metabolic processGO:0072593750.010
mitotic cell cycle processGO:19030472860.010
small molecule catabolic processGO:0044282920.010

HLA-DRB1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
immune system diseaseDOID:29141550.620
hypersensitivity reaction diseaseDOID:0060056250.576
nervous system diseaseDOID:8634310.118
central nervous system diseaseDOID:3311860.118
brain diseaseDOID:936730.014
Human
musculoskeletal system diseaseDOID:172230.012
disease of metabolismDOID:00146672950.012
disease of cellular proliferationDOID:145661740.012
connective tissue diseaseDOID:651090.007
bone diseaseDOID:0080001880.007
neurodegenerative diseaseDOID:12891020.007
bone inflammation diseaseDOID:3342100.001
rheumatoid arthritisDOID:714880.001
arthritisDOID:84880.001
demyelinating diseaseDOID:321340.001
multiple sclerosisDOID:237740.001
hypersensitivity reaction type iv diseaseDOID:291660.000
sarcoidosisDOID:1133530.000