Homo sapiens

152 known processes

PRKDC

protein kinase, DNA-activated, catalytic polypeptide

(Aliases: p350,DNAPK,HYRC1,DNA-PKcs,DNPK1,HYRC,XRCC7)

PRKDC biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
double strand break repairGO:00063021011.000
cellular response to dna damage stimulusGO:00069743791.000
mitotic cell cycle processGO:19030472860.997
dna conformation changeGO:00711031130.997
mitotic cell cycleGO:00002783260.995
nucleoside monophosphate catabolic processGO:00091251590.989
purine nucleoside monophosphate catabolic processGO:00091281580.988
positive regulation of dna metabolic processGO:0051054730.986
dna geometric changeGO:0032392320.985
chromatin organizationGO:00063253510.981
regulation of dna metabolic processGO:00510521530.979
purine ribonucleoside monophosphate catabolic processGO:00091691580.978
ribonucleoside monophosphate catabolic processGO:00091581580.976
atp metabolic processGO:00460341760.976
negative regulation of cell cycle phase transitionGO:1901988890.971
ribonucleoside monophosphate metabolic processGO:00091611870.970
negative regulation of cell deathGO:00605483450.969
organophosphate catabolic processGO:00464344300.962
dna repairGO:00062811980.959
cell cycle checkpointGO:00000751170.958
dna packagingGO:0006323770.954
negative regulation of programmed cell deathGO:00430693210.949
purine ribonucleoside triphosphate metabolic processGO:00092054110.941
chromatin assembly or disassemblyGO:0006333780.939
nucleoside monophosphate metabolic processGO:00091231910.937
purine ribonucleoside monophosphate metabolic processGO:00091671860.933
dna recombinationGO:0006310770.933
double strand break repair via nonhomologous end joiningGO:0006303100.929
regulation of cell cycle phase transitionGO:19019871260.926
atp catabolic processGO:00062001570.925
purine nucleoside monophosphate metabolic processGO:00091261860.922
mitotic cell cycle phase transitionGO:00447721620.919
telomere maintenanceGO:0000723320.918
nucleoside triphosphate metabolic processGO:00091414220.912
negative regulation of apoptotic processGO:00430663160.909
regulation of growth rateGO:004000910.905
determination of adult lifespanGO:000834020.904
dna dependent dna replicationGO:0006261440.900
mitotic nuclear divisionGO:00070671190.884
purine nucleoside triphosphate metabolic processGO:00091444120.882
post embryonic developmentGO:000979120.880
nucleoside triphosphate catabolic processGO:00091433940.876
dna damage checkpointGO:0000077680.855
ribonucleoside catabolic processGO:00424544060.851
purine nucleoside triphosphate catabolic processGO:00091463920.846
nucleoside catabolic processGO:00091644080.843
non recombinational repairGO:0000726140.834
mitotic sister chromatid segregationGO:0000070530.834
regulation of mitotic cell cycleGO:00073461890.824
nuclear divisionGO:00002801280.822
organelle localizationGO:0051640840.818
organelle fissionGO:00482851490.808
g2 dna damage checkpointGO:0031572260.803
dna duplex unwindingGO:0032508300.796
response to abiotic stimulusGO:00096283360.795
chromatin modificationGO:00165682980.778
apoptotic signaling pathwayGO:00971902680.777
dna integrity checkpointGO:0031570710.771
covalent chromatin modificationGO:00165692540.769
ribonucleoside triphosphate metabolic processGO:00091994120.768
regulation of cellular component biogenesisGO:00440872810.760
neuron differentiationGO:00301821380.742
purine containing compound catabolic processGO:00725234110.728
purine ribonucleoside triphosphate catabolic processGO:00092073910.722
nucleotide catabolic processGO:00091664080.721
somatic diversification of immunoglobulins involved in immune responseGO:000220830.713
purine ribonucleoside catabolic processGO:00461303980.698
mitotic cell cycle checkpointGO:0007093680.670
embryo developmentGO:00097901230.669
meiotic chromosome segregationGO:004513240.663
regulation of cell cycleGO:00517263930.649
sister chromatid segregationGO:0000819540.616
ribonucleoside triphosphate catabolic processGO:00092033910.611
cellular response to abiotic stimulusGO:00712141170.611
regulation of double strand break repairGO:2000779220.591
purine ribonucleoside metabolic processGO:00461284370.584
positive regulation of cellular component organizationGO:00511303760.584
establishment of protein localization to organelleGO:00725941720.583
purine nucleotide catabolic processGO:00061954050.575
generation of neuronsGO:00486991520.572
cell cycle phase transitionGO:00447701730.557
dna double strand break processingGO:0000729100.546
regulation of chromatin assembly or disassemblyGO:000167260.531
negative regulation of cell cycleGO:00457861930.513
chromatin remodelingGO:0006338550.508
ribonucleotide catabolic processGO:00092614050.508
negative regulation of mitotic cell cycle phase transitionGO:1901991850.508
mitotic dna integrity checkpointGO:0044774300.496
regulation of cell cycle processGO:00105642660.495
glycosyl compound catabolic processGO:19016584130.466
isotype switchingGO:004519030.463
base excision repairGO:0006284210.461
chromosome condensationGO:0030261150.449
response to uvGO:0009411730.445
cell divisionGO:00513011680.427
response to radiationGO:00093141510.424
purine nucleoside catabolic processGO:00061523980.420
dna strand elongation involved in dna replicationGO:000627130.409
establishment of organelle localizationGO:0051656590.409
dna strand elongationGO:002261650.401
female gamete generationGO:000729220.400
nucleus organizationGO:0006997280.393
negative regulation of cell cycle processGO:00109481210.391
cell agingGO:0007569520.385
mitotic dna damage checkpointGO:0044773280.381
chromatin silencingGO:0006342120.380
protein autoprocessingGO:001654040.369
dna replicationGO:00062601160.354
cellular macromolecule catabolic processGO:00442653800.333
circulatory system developmentGO:00723592620.332
response to oxygen containing compoundGO:19017003690.329
regulation of meiotic cell cycleGO:005144540.327
regulation of response to dna damage stimulusGO:2001020940.319
somatic recombination of immunoglobulin genes involved in immune responseGO:000220430.317
segmentationGO:003528240.315
metaphase plate congressionGO:0051310180.296
negative regulation of mitotic cell cycleGO:00459301020.294
regulation of multi organism processGO:00439001570.294
actin filament based processGO:00300292240.288
embryo development ending in birth or egg hatchingGO:0009792340.283
oogenesisGO:004847720.283
cell projection organizationGO:00300302520.282
double strand break repair via homologous recombinationGO:0000724500.278
agingGO:0007568660.275
chromatin assemblyGO:0031497610.267
positive regulation of programmed cell deathGO:00430682490.260
positive regulation of chromatin assembly or disassemblyGO:004579920.260
amine metabolic processGO:0009308440.255
meiosis iGO:000712740.250
cellular amino acid metabolic processGO:00065201160.249
mrna processingGO:00063971330.239
response to ionizing radiationGO:0010212650.238
protein catabolic processGO:00301633250.235
cellular amine metabolic processGO:0044106410.233
telomere organizationGO:0032200330.227
somatic recombination of immunoglobulin gene segmentsGO:001644740.218
single organism cellular localizationGO:19025803320.217
growthGO:00400072020.216
regulation of dna repairGO:0006282470.216
cardiovascular system developmentGO:00723582620.212
chemotaxisGO:00069351570.208
cell activation involved in immune responseGO:0002263300.207
nucleoside phosphate catabolic processGO:19012924120.201
regulation of chromosome segregationGO:0051983440.198
ras protein signal transductionGO:0007265730.197
negative regulation of dna metabolic processGO:0051053570.194
meiotic cell cycleGO:0051321130.193
heterochromatin organizationGO:007082860.189
regulation of anatomical structure morphogenesisGO:00226032860.186
regulation of nuclear divisionGO:0051783650.173
cellular component morphogenesisGO:00329893140.164
microtubule based processGO:00070172100.163
cellular response to uvGO:0034644320.160
endomembrane system organizationGO:00102561960.160
oocyte developmentGO:004859910.160
response to other organismGO:00517072610.158
intrinsic apoptotic signaling pathwayGO:00971931270.157
immunoglobulin production involved in immunoglobulin mediated immune responseGO:000238150.155
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.155
double strand break repair via single strand annealingGO:004500240.152
viral processGO:00160321460.152
regulation of bindingGO:00510981110.145
positive regulation of cell cycleGO:00457871400.142
positive regulation of developmental processGO:00510943140.142
cellular macromolecular complex assemblyGO:00346223240.141
membrane organizationGO:00610242920.141
protein importGO:00170381300.140
neuron developmentGO:00486661130.137
positive regulation of cell deathGO:00109422630.135
cell type specific apoptotic processGO:00972851250.134
nervous system developmentGO:00073992930.133
positive regulation of hydrolase activityGO:00513453310.133
mrna metabolic processGO:00160711750.126
histone modificationGO:00165702510.124
lymphocyte activationGO:00466491330.123
cellular response to ionizing radiationGO:0071479320.122
anatomical structure homeostasisGO:00602491000.119
regulation of mitosisGO:0007088630.118
rna export from nucleusGO:0006405330.118
regulation of gene expression epigeneticGO:0040029730.118
lipid metabolic processGO:00066293810.118
single strand break repairGO:000001260.117
positive regulation of transportGO:00510503360.117
leukocyte activationGO:00453211640.116
positive regulation of growthGO:0045927580.116
regulation of protein complex assemblyGO:00432541470.115
dna catabolic processGO:0006308490.114
cell morphogenesisGO:00009022960.114
gene silencingGO:0016458490.113
response to light stimulusGO:0009416870.113
multicellular organismal agingGO:001025930.113
protein processingGO:00164852260.112
reproductionGO:0000003630.111
mitotic recombinationGO:000631280.111
single organism membrane organizationGO:00448022680.107
neurogenesisGO:00220081690.105
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.104
regulation of cellular amine metabolic processGO:0033238110.104
regulation of cellular response to stressGO:00801352440.103
regulation of protein localizationGO:00328802960.102
chordate embryonic developmentGO:0043009340.102
neuron projection developmentGO:00311751060.100
positive regulation of transferase activityGO:00513472270.100
somatic diversification of immune receptorsGO:000220080.100
dna ligationGO:0006266100.098
mismatch repairGO:0006298150.097
regulation of tor signalingGO:0032006300.096
regulation of dna recombinationGO:0000018230.096
rna interferenceGO:001624640.094
meiotic nuclear divisionGO:0007126100.093
positive regulation of cell proliferationGO:00082843010.093
regulation of establishment of protein localizationGO:00702012420.092
digestive tract morphogenesisGO:0048546560.091
peptidyl serine phosphorylationGO:00181051010.089
response to external biotic stimulusGO:00432072610.088
nuclear transportGO:00511691790.087
macromolecule methylationGO:0043414970.086
regulation of growthGO:00400081650.085
regulation of nervous system developmentGO:0051960880.084
negative regulation of organelle organizationGO:00106391260.084
mitotic centrosome separationGO:000710010.082
chromosome segregationGO:00070591140.081
single organism carbohydrate metabolic processGO:00447231930.080
response to biotic stimulusGO:00096072760.079
positive regulation of organelle organizationGO:00106381950.078
hematopoietic stem cell differentiationGO:006021840.076
reciprocal dna recombinationGO:003582540.075
telomere maintenance via recombinationGO:000072240.075
cell growthGO:00160491600.075
signal transduction in response to dna damageGO:0042770570.073
cell fate determinationGO:000170930.072
single organism nuclear importGO:19025931040.071
regulation of cellular component movementGO:00512703340.070
cell morphogenesis involved in differentiationGO:00009041440.070
positive regulation of protein complex assemblyGO:0031334860.070
reciprocal meiotic recombinationGO:000713140.070
positive regulation of heterochromatin assemblyGO:003145310.069
positive regulation of apoptotic processGO:00430652460.069
signal transduction by p53 class mediatorGO:0072331720.069
positive regulation of cellular component biogenesisGO:00440891580.067
positive regulation of protein transportGO:00512221350.065
response to hypoxiaGO:0001666960.065
carbohydrate derivative biosynthetic processGO:19011372070.065
ribosomal protein import into nucleusGO:000661020.065
ameboidal type cell migrationGO:00016671350.064
viral life cycleGO:00190581320.063
regulation of cell cycle g1 s phase transitionGO:1902806420.063
nuclear pore complex assemblyGO:005129270.062
protein maturationGO:00516042330.061
mitotic spindle organizationGO:0007052270.060
cell activationGO:00017752130.059
nuclear importGO:00511701060.059
protein localization to organelleGO:00333652800.059
b cell activationGO:0042113330.059
response to hormoneGO:00097251750.056
neuron deathGO:0070997650.055
negative regulation of cellular component organizationGO:00511292350.055
protein autophosphorylationGO:00467771230.054
nucleic acid phosphodiester bond hydrolysisGO:00903051020.053
positive regulation of cytoplasmic transportGO:1903651820.053
cell developmentGO:00484683280.053
somatic cell dna recombinationGO:001644460.053
response to organonitrogen compoundGO:00102431560.052
mitotic g2 m transition checkpointGO:004481890.052
regulation of protein bindingGO:0043393660.052
organonitrogen compound biosynthetic processGO:19015662000.051
protein adp ribosylationGO:000647190.051
blastocyst developmentGO:000182430.051
lipid biosynthetic processGO:00086101770.051
regulation of chromatin modificationGO:1903308510.051
cellular protein complex assemblyGO:00436231880.050
translationGO:00064121320.050
regulation of heterochromatin assemblyGO:003144510.050
nucleocytoplasmic transportGO:00069131760.049
rna transportGO:0050658390.049
intracellular protein transportGO:00068862700.049
positive regulation of immunoglobulin mediated immune responseGO:000289140.048
cell cycle arrestGO:0007050710.047
response to gamma radiationGO:0010332140.047
regulation of cellular ketone metabolic processGO:0010565500.047
regulation of chromatin assemblyGO:001084720.046
single organism reproductive processGO:0044702980.045
regulation of dna methylationGO:004403020.044
histone exchangeGO:004348630.044
positive regulation of transcription initiation from rna polymerase ii promoterGO:006026140.044
dna damage response detection of dna damageGO:004276930.044
regulation of cytoplasmic transportGO:19036491490.043
cellular ketone metabolic processGO:0042180800.042
purine ribonucleotide catabolic processGO:00091544040.042
enzyme linked receptor protein signaling pathwayGO:00071673030.042
recombinational repairGO:0000725500.042
negative regulation of cellular protein metabolic processGO:00322693530.042
dna unwinding involved in dna replicationGO:000626820.041
generation of precursor metabolites and energyGO:0006091680.040
immune system developmentGO:00025201950.040
embryonic morphogenesisGO:0048598850.039
response to oxidative stressGO:00069791210.039
regulation of microtubule polymerization or depolymerizationGO:0031110270.039
regenerationGO:003109940.039
regulation of nucleocytoplasmic transportGO:0046822980.039
glycoprotein biosynthetic processGO:0009101910.038
regulation of cell morphogenesisGO:00226041530.038
positive regulation of multi organism processGO:0043902560.038
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630500.038
cellular response to oxygen containing compoundGO:19017012760.038
macromolecule glycosylationGO:0043413630.038
tube developmentGO:00352951250.038
small gtpase mediated signal transductionGO:0007264780.038
cellular response to transforming growth factor beta stimulusGO:0071560940.038
regulation of mitotic cell cycle phase transitionGO:19019901180.037
meiotic cell cycle processGO:190304680.037
mitotic chromosome condensationGO:0007076110.037
pattern specification processGO:0007389430.037
peptidyl lysine modificationGO:00182051440.037
taxisGO:00423301570.037
somatic diversification of immunoglobulinsGO:001644560.036
cellular response to insulin stimulusGO:0032869410.035
positive regulation of response to dna damage stimulusGO:2001022430.035
dna ligation involved in dna repairGO:005110340.035
regulation of cell developmentGO:00602841610.035
multi organism cellular processGO:00447641560.034
positive regulation of cell differentiationGO:00455972110.034
hematopoietic progenitor cell differentiationGO:0002244380.034
maintenance of dna repeat elementsGO:004357040.034
regulation of viral processGO:00507921030.034
regulation of neuron apoptotic processGO:0043523350.034
heterochromatin assemblyGO:003150760.033
cytoplasmic transportGO:00164823790.033
regulation of cell divisionGO:00513021160.033
microtubule cytoskeleton organizationGO:00002261760.033
regulation of transcription by chromatin organizationGO:003440110.033
regulation of small gtpase mediated signal transductionGO:00510561560.032
dna methylation or demethylationGO:0044728190.032
smad protein import into nucleusGO:0007184130.032
development of primary sexual characteristicsGO:0045137350.032
oocyte differentiationGO:000999420.032
negative regulation of neuron apoptotic processGO:0043524230.031
positive regulation of kinase activityGO:00336742040.031
regulation of cellular amino acid metabolic processGO:000652160.031
cellular response to oxygen levelsGO:0071453550.030
positive regulation of phosphorylationGO:00423273940.030
regulation of chromatin organizationGO:1902275560.030
interstrand cross link repairGO:003629730.030
tor signalingGO:0031929390.030
regulation of chromosome organizationGO:00330441030.029
histone methylationGO:0016571600.029
methylationGO:00322591060.029
regulation of dna replicationGO:0006275680.029
system processGO:00030083490.029
regulation of developmental growthGO:0048638300.029
nucleotide excision repairGO:0006289310.028
ribonucleoprotein complex subunit organizationGO:0071826810.028
positive regulation of cell developmentGO:0010720920.028
immune responseGO:00069553070.028
regulation of response to external stimulusGO:00321012220.028
immune effector processGO:00022521590.028
regulation of helicase activityGO:005109580.028
regulation of ras protein signal transductionGO:00465781550.028
dna damage response signal transduction by p53 class mediatorGO:0030330440.028
positive regulation of viral processGO:0048524370.028
leukocyte activation involved in immune responseGO:0002366300.027
actin cytoskeleton organizationGO:00300362070.027
rna catabolic processGO:0006401710.027
regulation of proteolysisGO:00301622930.026
microtubule polymerization or depolymerizationGO:0031109370.026
molting cycleGO:0042303280.026
mitotic dna replication checkpointGO:003331420.026
compound eye developmentGO:004874910.026
response to purine containing compoundGO:0014074400.026
cell projection morphogenesisGO:00488581290.026
response to starvationGO:0042594590.026
epithelium developmentGO:00604292270.026
positive regulation of immune system processGO:00026842830.025
positive regulation of isotype switching to iga isotypesGO:004829820.025
regulation of protein processingGO:00706131500.025
reproductive system developmentGO:0061458560.025
cell part morphogenesisGO:00329901370.025
vasculature developmentGO:00019441810.025
regulation of cell migrationGO:00303342890.025
regulation of cell growthGO:00015581350.025
neuron apoptotic processGO:0051402390.024
negative regulation of neuron deathGO:1901215320.024
positive regulation of protein kinase activityGO:00458601900.024
regulation of cell motilityGO:20001452990.024
regulation of cell differentiationGO:00455953930.024
rna processingGO:00063962550.024
organ morphogenesisGO:00098871470.023
histone h3 k4 methylationGO:0051568270.023
regulation of cysteine type endopeptidase activityGO:20001161270.023
intrinsic apoptotic signaling pathway by p53 class mediatorGO:0072332370.023
chromatin remodeling at centromereGO:003105520.023
stem cell differentiationGO:0048863930.022
regulation of kinase activityGO:00435493140.022
regulation of viral genome replicationGO:0045069480.022
carbohydrate metabolic processGO:00059752070.022
positive regulation of protein phosphorylationGO:00019343130.022
blood vessel morphogenesisGO:00485141620.022
cartilage developmentGO:0051216310.021
sex determinationGO:000753030.021
protein glycosylationGO:0006486620.021
protein targeting to nucleusGO:00447441040.020
positive regulation of chromatin modificationGO:1903310300.020
vesicle mediated transportGO:00161923710.020
septum secundum developmentGO:000328520.020
regulation of cytoskeleton organizationGO:00514931770.020
tripartite regional subdivisionGO:000735120.020
regionalizationGO:0003002290.020
regulation of apoptotic signaling pathwayGO:20012331750.020
protein poly adp ribosylationGO:007021230.020
cell morphogenesis involved in neuron differentiationGO:0048667440.020
regulation of centriole replicationGO:004659970.020
protein targetingGO:00066051870.020
posttranscriptional regulation of gene expressionGO:00106082130.019
maintenance of locationGO:00512351120.019
positive regulation of intracellular transportGO:00323881040.019
anatomical structure formation involved in morphogenesisGO:00486462840.019
rna localizationGO:0006403410.019
regulation of protein maturationGO:19033171500.019
humoral immune responseGO:0006959490.019
negative regulation of intracellular signal transductionGO:19025321830.019
atrial septum primum morphogenesisGO:000328910.019
eye developmentGO:0001654420.019
symbiosis encompassing mutualism through parasitismGO:00444031560.018
purine nucleotide biosynthetic processGO:0006164840.018
nucleosome assemblyGO:0006334500.018
nls bearing protein import into nucleusGO:000660720.018
positive regulation of cellular amine metabolic processGO:003324070.018
cellular response to radiationGO:0071478650.018
mitotic g2 dna damage checkpointGO:000709570.018
multicellular organismal reproductive processGO:0048609400.018
positive regulation of bindingGO:0051099450.018
dephosphorylationGO:00163112090.018
negative regulation of cellular catabolic processGO:0031330830.018
leukocyte differentiationGO:0002521980.018
interspecies interaction between organismsGO:00444191560.017
negative regulation of proteolysisGO:00458611320.017
axon developmentGO:0061564340.017
positive regulation of developmental growthGO:0048639160.017
positive regulation of helicase activityGO:005109660.017
negative regulation of cell differentiationGO:00455961710.017
regulation of endopeptidase activityGO:00525481700.017
spindle localizationGO:0051653120.017
response to alkaloidGO:0043279200.017
centrosome separationGO:005129930.016
gonad developmentGO:0008406340.016
positive regulation of cellular amino acid metabolic processGO:004576430.016
cellular response to organonitrogen compoundGO:00714171240.016
lipid localizationGO:00108761060.016
regulation of translationGO:0006417890.016
regulation of peptidase activityGO:00525471800.015
monocarboxylic acid metabolic processGO:00327871850.015
regulation of intracellular protein transportGO:00331571230.015
g2 m transition of mitotic cell cycleGO:0000086410.015
cellular response to hormone stimulusGO:00328701250.015
dna hypermethylationGO:004402610.015
response to caffeineGO:003100030.015
regulation of histone modificationGO:0031056470.014
organelle assemblyGO:00709251760.014
positive regulation of dendrite morphogenesisGO:005077530.014
hematopoietic or lymphoid organ developmentGO:00485341860.014
regulation of angiogenesisGO:0045765920.014
heart developmentGO:0007507950.014
establishment of spindle localizationGO:0051293120.014
response to nitrogen compoundGO:19016981840.014
gastrulationGO:0007369510.014
regulation of locomotionGO:00400123290.014
regulation of protein localization to nucleusGO:1900180850.014
negative regulation of protein maturationGO:19033181420.014
multicellular organism reproductionGO:0032504420.014
negative regulation of gene silencing by rnaGO:006096730.014
nucleoside phosphate biosynthetic processGO:19012931090.014
response to inorganic substanceGO:00100351270.013
muscle contractionGO:0006936730.013
negative regulation of catalytic activityGO:00430863350.013
hemopoiesisGO:00300971800.013
intracellular mrna localizationGO:000829810.013
establishment of chromosome localizationGO:0051303200.013
spindle organizationGO:0007051530.013
cellular response to light stimulusGO:0071482340.013
negative regulation of hydrolase activityGO:00513461820.013
protein methylationGO:0006479740.013
regulation of homeostatic processGO:00328441210.013
wnt signaling pathwayGO:00160551560.013
blastoderm segmentationGO:000735020.013
nuclear pore organizationGO:0006999100.013
regulation of protein targetingGO:1903533910.013
spermatid developmentGO:000728640.013
cellular response to external stimulusGO:00714961110.012

PRKDC disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:145661740.480
organ system cancerDOID:00506861640.090
cancerDOID:1621670.090
nervous system diseaseDOID:8634310.073
neuropathyDOID:870520.073