Homo sapiens

5 known processes

PRODH

proline dehydrogenase (oxidase) 1

(Aliases: FLJ33744,TP53I6,POX,PRODH1,PRODH2,HSPOX2,MGC148079,PIG6,SCZD4,MGC148078)

PRODH biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular lipid metabolic processGO:00442553030.142
cellular amino acid metabolic processGO:00065201160.131
cellular ketone metabolic processGO:0042180800.095
small gtpase mediated signal transductionGO:0007264780.091
ras protein signal transductionGO:0007265730.085
purine ribonucleoside triphosphate catabolic processGO:00092073910.084
lipid metabolic processGO:00066293810.084
purine ribonucleoside catabolic processGO:00461303980.084
purine ribonucleoside metabolic processGO:00461284370.083
amine metabolic processGO:0009308440.082
cellular amine metabolic processGO:0044106410.081
regulation of cellular amine metabolic processGO:0033238110.079
nucleoside triphosphate metabolic processGO:00091414220.077
post embryonic developmentGO:000979120.075
regulation of cellular component movementGO:00512703340.075
response to oxygen containing compoundGO:19017003690.075
small molecule biosynthetic processGO:00442831570.071
positive regulation of nucleotide metabolic processGO:00459812300.070
purine nucleoside triphosphate metabolic processGO:00091444120.070
monocarboxylic acid metabolic processGO:00327871850.070
organophosphate catabolic processGO:00464344300.069
regulation of cellular amino acid metabolic processGO:000652160.068
ribonucleotide catabolic processGO:00092614050.068
membrane organizationGO:00610242920.065
ribonucleoside catabolic processGO:00424544060.065
purine ribonucleoside triphosphate metabolic processGO:00092054110.064
ribonucleoside triphosphate metabolic processGO:00091994120.063
nucleoside catabolic processGO:00091644080.062
purine containing compound catabolic processGO:00725234110.061
regulation of cellular ketone metabolic processGO:0010565500.060
purine nucleotide catabolic processGO:00061954050.059
regulation of purine nucleotide metabolic processGO:19005422640.059
purine nucleoside triphosphate catabolic processGO:00091463920.058
purine nucleoside catabolic processGO:00061523980.058
positive regulation of transportGO:00510503360.058
nucleoside triphosphate catabolic processGO:00091433940.057
ribonucleoside triphosphate catabolic processGO:00092033910.056
nucleotide catabolic processGO:00091664080.055
positive regulation of cellular amino acid metabolic processGO:004576430.055
positive regulation of cellular amine metabolic processGO:003324070.055
regulation of cell motilityGO:20001452990.054
positive regulation of hydrolase activityGO:00513453310.054
positive regulation of catabolic processGO:00098963100.054
glycosyl compound catabolic processGO:19016584130.053
gtp catabolic processGO:00061842370.053
regulation of cell migrationGO:00303342890.052
regulation of nucleoside metabolic processGO:00091182090.051
oxidation reduction processGO:00551143960.050
purine ribonucleotide catabolic processGO:00091544040.050
system processGO:00030083490.050
determination of adult lifespanGO:000834020.048
gtp metabolic processGO:00460392390.048
cellular response to endogenous stimulusGO:00714953360.047
chemical homeostasisGO:00488783060.047
regulation of gtp catabolic processGO:00331241800.046
female gamete generationGO:000729220.046
actin filament based processGO:00300292240.046
organonitrogen compound biosynthetic processGO:19015662000.046
nucleoside phosphate catabolic processGO:19012924120.045
positive regulation of cellular catabolic processGO:00313312840.045
positive regulation of ras gtpase activityGO:00323201170.044
cardiac muscle cell contractionGO:008600340.044
positive regulation of purine nucleotide metabolic processGO:19005442270.044
positive regulation of phosphorylationGO:00423273940.044
multicellular organismal agingGO:001025930.043
regulation of nucleotide metabolic processGO:00061402690.042
transmembrane transportGO:00550853990.042
organic acid biosynthetic processGO:0016053970.041
rho protein signal transductionGO:0007266260.041
cell morphogenesisGO:00009022960.041
muscle contractionGO:0006936730.041
regulation of nucleotide catabolic processGO:00308112050.041
guanosine containing compound catabolic processGO:19010692390.041
carboxylic acid biosynthetic processGO:0046394970.041
muscle system processGO:0003012810.040
oogenesisGO:004847720.040
segmentationGO:003528240.040
negative regulation of apoptotic processGO:00430663160.040
guanosine containing compound metabolic processGO:19010682440.039
lipid biosynthetic processGO:00086101770.039
ion transmembrane transportGO:00342203380.039
cell developmentGO:00484683280.038
nervous system developmentGO:00073992930.038
metal ion transportGO:00300012720.038
positive regulation of nucleotide catabolic processGO:00308131850.037
positive regulation of cellular component organizationGO:00511303760.037
regenerationGO:003109940.037
negative regulation of cell deathGO:00605483450.037
positive regulation of tooth mineralizationGO:007017220.037
regulation of locomotionGO:00400123290.036
immune responseGO:00069553070.036
positive regulation of gtp catabolic processGO:00331261660.036
negative regulation of protein metabolic processGO:00512483910.035
regulation of purine nucleotide catabolic processGO:00331212050.035
positive regulation of purine nucleotide catabolic processGO:00331231850.034
endomembrane system organizationGO:00102561960.034
negative regulation of catalytic activityGO:00430863350.034
response to woundingGO:00096111680.034
cellular component morphogenesisGO:00329893140.034
vasculature developmentGO:00019441810.034
regulation of kinase activityGO:00435493140.033
positive regulation of nucleoside metabolic processGO:00459791860.033
single organism membrane organizationGO:00448022680.033
small molecule catabolic processGO:0044282920.033
regulation of small gtpase mediated signal transductionGO:00510561560.032
negative regulation of programmed cell deathGO:00430693210.032
protein localization to membraneGO:00726571600.032
carboxylic acid catabolic processGO:0046395710.032
cell adhesionGO:00071553250.031
carbohydrate derivative biosynthetic processGO:19011372070.031
blastoderm segmentationGO:000735020.031
positive regulation of gtpase activityGO:00435471660.031
action potentialGO:0001508340.031
anatomical structure formation involved in morphogenesisGO:00486462840.031
negative regulation of cellular component organizationGO:00511292350.030
negative regulation of cell proliferationGO:00082852280.030
enzyme linked receptor protein signaling pathwayGO:00071673030.030
cation transportGO:00068123310.030
cell projection organizationGO:00300302520.030
regulation of cell cycleGO:00517263930.030
cardiovascular system developmentGO:00723582620.029
salivary gland morphogenesisGO:000743540.029
cellular response to oxygen containing compoundGO:19017012760.029
carbohydrate metabolic processGO:00059752070.029
regulation of protein localizationGO:00328802960.029
biological adhesionGO:00226103310.028
negative regulation of multicellular organismal processGO:00512413170.028
negative regulation of developmental processGO:00510932470.028
epidermis morphogenesisGO:004873030.028
mitotic cell cycle processGO:19030472860.028
cytoplasmic transportGO:00164823790.027
negative regulation of cellular protein metabolic processGO:00322693530.027
actin mediated cell contractionGO:0070252120.027
single organism cellular localizationGO:19025803320.027
regulation of cytoskeleton organizationGO:00514931770.027
protein processingGO:00164852260.027
regulation of cell cycle processGO:00105642660.026
regulation of ras protein signal transductionGO:00465781550.026
regulation of response to external stimulusGO:00321012220.026
regulation of gtpase activityGO:00430871800.026
regulation of ras gtpase activityGO:00323181280.026
positive regulation of cell proliferationGO:00082843010.026
calcium ion transmembrane transportGO:0070588760.026
lipid transportGO:0006869900.026
single organism carbohydrate metabolic processGO:00447231930.026
regulation of proteolysisGO:00301622930.025
locomotory behaviorGO:000762610.025
regulation of establishment of protein localizationGO:00702012420.025
protein catabolic processGO:00301633250.025
glycerolipid metabolic processGO:00464861070.025
regulation of actin filament based processGO:00329701410.025
plasma membrane organizationGO:00070091150.025
mitotic cell cycleGO:00002783260.025
signal transduction by phosphorylationGO:00230142970.025
cardiac muscle contractionGO:0060048340.025
cation transmembrane transportGO:00986552380.024
organophosphate biosynthetic processGO:00904071630.024
response to inorganic substanceGO:00100351270.024
negative regulation of phosphorus metabolic processGO:00105632670.024
positive regulation of immune system processGO:00026842830.024
neurological system processGO:00508771630.024
organic anion transportGO:00157111030.024
innate immune responseGO:00450871780.024
vesicle mediated transportGO:00161923710.023
wnt signaling pathwayGO:00160551560.023
regulation of cell differentiationGO:00455953930.023
circulatory system developmentGO:00723592620.023
regulation of synaptic plasticityGO:004816730.023
anion transportGO:00068201610.023
cell cycle phase transitionGO:00447701730.023
regulation of protein kinase activityGO:00458592890.023
calcium ion transportGO:00068161470.023
establishment of protein localization to membraneGO:00901501210.023
cell cell signalingGO:00072671550.022
protein maturationGO:00516042330.022
regulation of anatomical structure morphogenesisGO:00226032860.022
positive regulation of apoptotic processGO:00430652460.022
response to abiotic stimulusGO:00096283360.022
oocyte developmentGO:004859910.022
long chain fatty acid metabolic processGO:0001676300.022
organic acid catabolic processGO:0016054710.022
cell substrate adhesionGO:00315891320.022
neurogenesisGO:00220081690.022
ion homeostasisGO:00508012300.022
cellular response to dna damage stimulusGO:00069743790.022
dephosphorylationGO:00163112090.022
defense responseGO:00069523150.022
response to nitrogen compoundGO:19016981840.022
protein localization to plasma membraneGO:0072659930.021
negative regulation of cell motilityGO:20001461040.021
sulfur compound metabolic processGO:00067901010.021
oocyte differentiationGO:000999420.021
cell growthGO:00160491600.021
response to lipidGO:00339932060.021
inorganic ion transmembrane transportGO:00986602310.021
maintenance of locationGO:00512351120.021
organic hydroxy compound metabolic processGO:19016151470.021
negative regulation of phosphate metabolic processGO:00459362670.021
actin filament based movementGO:0030048170.021
regulation of ion transportGO:00432691890.021
positive regulation of cell deathGO:00109422630.021
single organism cell adhesionGO:00986021790.021
negative regulation of hydrolase activityGO:00513461820.021
glial cell migrationGO:000834740.021
response to organic cyclic compoundGO:00140702040.021
cellular homeostasisGO:00197251960.021
inorganic cation transmembrane transportGO:00986621940.020
fatty acid metabolic processGO:00066311150.020
negative regulation of cell cycleGO:00457861930.020
peripheral nervous system developmentGO:000742220.020
epithelium developmentGO:00604292270.020
cellular macromolecular complex assemblyGO:00346223240.020
response to hormoneGO:00097251750.020
secretionGO:00469032540.020
negative regulation of cellular amine metabolic processGO:003323930.019
negative regulation of cellular amino acid metabolic processGO:004576320.019
positive regulation of protein phosphorylationGO:00019343130.019
unsaturated fatty acid metabolic processGO:0033559370.019
angiogenesisGO:00015251470.019
cytokine productionGO:00018162470.019
lipid localizationGO:00108761060.019
blood vessel morphogenesisGO:00485141620.019
regulation of membrane potentialGO:0042391950.019
forebrain regionalizationGO:002187130.019
response to axon injuryGO:004867810.019
regulation of cellular response to stressGO:00801352440.019
positive regulation of programmed cell deathGO:00430682490.019
monocarboxylic acid biosynthetic processGO:0072330670.019
regulation of peptidase activityGO:00525471800.019
striated muscle contractionGO:0006941520.019
rhythmic behaviorGO:000762220.019
regulation of cellular component biogenesisGO:00440872810.018
regulation of mapk cascadeGO:00434082620.018
taxisGO:00423301570.018
neuromuscular junction developmentGO:000752830.018
positive regulation of cell motilityGO:20001471770.018
protein localization to organelleGO:00333652800.018
response to biotic stimulusGO:00096072760.018
actin cytoskeleton organizationGO:00300362070.018
canonical wnt signaling pathwayGO:00600701160.018
spermatid differentiationGO:004851540.018
blood circulationGO:00080151130.018
mitochondrion organizationGO:00070051560.018
regulation of hormone levelsGO:00108171250.018
chemotaxisGO:00069351570.018
cellular response to nitrogen compoundGO:19016991440.018
regulation of mitotic cell cycleGO:00073461890.018
regulation of cytokine productionGO:00018172320.018
organ morphogenesisGO:00098871470.018
divalent inorganic cation transportGO:00725111580.018
av node cell to bundle of his cell communicationGO:008606740.018
wound healingGO:00420601150.018
hair follicle morphogenesisGO:003106920.017
mitotic cell cycle phase transitionGO:00447721620.017
regulation of cell growthGO:00015581350.017
regulation of endopeptidase activityGO:00525481700.017
cellular chemical homeostasisGO:00550821800.017
negative regulation of cellular component movementGO:00512711060.017
organelle assemblyGO:00709251760.017
sequestering of metal ionGO:0051238240.017
positive regulation of cytokine productionGO:00018191670.017
cell junction organizationGO:0034330790.017
response to growth factorGO:00708482050.017
neuron projection regenerationGO:003110210.017
circulatory system processGO:00030131130.017
regulation of wnt signaling pathwayGO:00301111230.017
negative regulation of cell migrationGO:00303361020.017
multicellular organismal signalingGO:0035637340.017
phospholipid metabolic processGO:0006644990.017
protein modification by small protein conjugationGO:00324463420.017
positive regulation of kinase activityGO:00336742040.017
morphogenesis of embryonic epitheliumGO:001633140.017
response to other organismGO:00517072610.017
intracellular protein transportGO:00068862700.017
generation of neuronsGO:00486991520.017
response to metal ionGO:0010038840.017
ribonucleoside monophosphate metabolic processGO:00091611870.017
negative regulation of intracellular signal transductionGO:19025321830.017
tripartite regional subdivisionGO:000735120.016
regulation of multi organism processGO:00439001570.016
divalent metal ion transportGO:00708381520.016
vitamin e metabolic processGO:004236010.016
positive regulation of organic acid transportGO:003289230.016
regulation of intracellular transportGO:00323861950.016
glycerophospholipid metabolic processGO:0006650840.016
alpha amino acid metabolic processGO:1901605720.016
anterior posterior axis specificationGO:000994820.016
renal water homeostasisGO:000309140.016
cellular macromolecule catabolic processGO:00442653800.016
negative regulation of locomotionGO:00400131180.016
cellular response to cytokine stimulusGO:00713451810.016
regulation of neural precursor cell proliferationGO:200017740.016
reactive oxygen species biosynthetic processGO:190340940.016
response to organonitrogen compoundGO:00102431560.016
ameboidal type cell migrationGO:00016671350.016
memoryGO:000761330.016
neuroblast proliferationGO:000740540.016
sex determinationGO:000753030.016
phylloquinone metabolic processGO:004237420.016
regulation of secretionGO:00510461940.016
menaquinone metabolic processGO:000923330.016
apoptotic signaling pathwayGO:00971902680.016
circadian behaviorGO:004851220.016
inner ear morphogenesisGO:004247240.016
regulation of response to woundingGO:19030341010.016
regulation of bindingGO:00510981110.016
cellular modified amino acid metabolic processGO:0006575640.016
growthGO:00400072020.016
icosanoid metabolic processGO:0006690350.016
adult locomotory behaviorGO:000834410.016
regulation of homeostatic processGO:00328441210.016
cell projection morphogenesisGO:00488581290.016
drinking behaviorGO:004275610.016
regulation of transferase activityGO:00513383550.016
regulation of protein maturationGO:19033171500.016
reactive oxygen species metabolic processGO:0072593750.016
negative regulation of transportGO:00510511760.015
tissue regenerationGO:004224630.015
cell part morphogenesisGO:00329901370.015
motor neuron axon guidanceGO:000804520.015
nucleoside phosphate biosynthetic processGO:19012931090.015
positive regulation of protein kinase activityGO:00458601900.015
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.015
secretion by cellGO:00329402260.015
negative regulation of protein processingGO:00109551420.015
positive regulation of odontogenesisGO:004248230.015
tube developmentGO:00352951250.015
purine ribonucleoside monophosphate metabolic processGO:00091671860.015
regulation of muscle system processGO:0090257530.015
anterior posterior axis specification embryoGO:000859520.015
cellular protein complex assemblyGO:00436231880.015
spermatid developmentGO:000728640.015
regulation of cell morphogenesisGO:00226041530.015
regulation of protein processingGO:00706131500.015
regulation of cell cycle phase transitionGO:19019871260.015
interspecies interaction between organismsGO:00444191560.015
blood vessel developmentGO:00015681720.015
multicellular organismal response to stressGO:003355510.015
endocytosisGO:00068971590.015
transmission of nerve impulseGO:0019226110.015
purine containing compound biosynthetic processGO:0072522880.015
cell fate determinationGO:000170930.015
immune system developmentGO:00025201950.015
somatic stem cell maintenanceGO:003501940.015
lipid catabolic processGO:0016042840.015
positive regulation of secretion by cellGO:19035321080.015
cell projection assemblyGO:00300311260.015
histone modificationGO:00165702510.015
peptidyl tyrosine modificationGO:00182121700.015
positive regulation of organelle organizationGO:00106381950.015
nucleotide biosynthetic processGO:00091651090.015
regulation of immune responseGO:00507762010.014
neuron differentiationGO:00301821380.014
protein autophosphorylationGO:00467771230.014
fatty acid derivative metabolic processGO:1901568350.014
regulation of mitotic cell cycle phase transitionGO:19019901180.014
reactive nitrogen species metabolic processGO:200105730.014
negative regulation of endopeptidase activityGO:0010951840.014
alcohol metabolic processGO:00060661140.014
mapk cascadeGO:00001652880.014
ribonucleotide biosynthetic processGO:0009260810.014
photoreceptor cell differentiationGO:004653020.014
ossificationGO:00015031210.014
regulation of growthGO:00400081650.014
regulation of canonical wnt signaling pathwayGO:0060828880.014
t cell differentiation in thymusGO:003307740.014
vitamin k catabolic processGO:004237720.014
cellular protein catabolic processGO:00442572610.014
negative regulation of organelle organizationGO:00106391260.014
ribose phosphate biosynthetic processGO:0046390820.014
nitrogen compound transportGO:00717051910.014
midgut developmentGO:000749410.014
positive regulation of mapk cascadeGO:00434101900.014
negative regulation of proteolysisGO:00458611320.014
positive regulation of fatty acid transportGO:200019330.014
response to fungusGO:000962040.014
coenzyme metabolic processGO:0006732650.014
positive regulation of secretionGO:00510471160.014
astrocyte differentiationGO:004870840.014
cell morphogenesis involved in differentiationGO:00009041440.014
regulation of rho gtpase activityGO:0032319660.014
positive regulation of immune responseGO:00507781590.014
atp metabolic processGO:00460341760.014
myosin filament assemblyGO:003103420.014
positive regulation of rho gtpase activityGO:0032321560.014
sequestering of calcium ionGO:0051208170.013
negative regulation of icosanoid secretionGO:003230420.013
neuron fate commitmentGO:004866320.013
hindbrain developmentGO:003090230.013
establishment of protein localization to plasma membraneGO:0090002680.013
proteolysis involved in cellular protein catabolic processGO:00516032440.013
symbiosis encompassing mutualism through parasitismGO:00444031560.013
epithelial cell proliferationGO:00506731280.013
leukotriene b4 metabolic processGO:003610220.013
regulation of vesicle mediated transportGO:00606271300.013
activation of immune responseGO:00022531140.013
regulation of meiotic cell cycleGO:005144540.013
chromatin organizationGO:00063253510.013
regulation of protein catabolic processGO:00421761550.013
nucleoside monophosphate metabolic processGO:00091231910.013
purine nucleoside monophosphate metabolic processGO:00091261860.013
i kappab kinase nf kappab signalingGO:00072491660.013
posttranscriptional regulation of gene expressionGO:00106082130.013
cell fate commitment involved in pattern specificationGO:006058110.013
peptidyl tyrosine phosphorylationGO:00181081700.013
cellular response to growth factor stimulusGO:00713631970.013
endodermal cell fate commitmentGO:000171140.013
steroid metabolic processGO:0008202940.013
muscle cell fate commitmentGO:004269340.013
cellular amide metabolic processGO:0043603690.013
organelle fissionGO:00482851490.013
negative regulation of cell cycle processGO:00109481210.013
single organismal cell cell adhesionGO:00163371480.013
positive regulation of cortisol biosynthetic processGO:200006610.013
9 cis retinoic acid metabolic processGO:004290510.013
ketone catabolic processGO:004218230.013
oxidative stress induced premature senescenceGO:009040330.013
cofactor metabolic processGO:0051186870.013
regulation of reactive oxygen species biosynthetic processGO:190342630.013
somitogenesisGO:000175620.013
negative regulation of catabolic processGO:00098951040.013
cell divisionGO:00513011680.013
cell junction assemblyGO:0034329670.013
organic acid transportGO:0015849650.013
microtubule based processGO:00070172100.013
lipid modificationGO:0030258840.013
negative regulation of axonogenesisGO:005077140.013
response to lithium ionGO:001022620.013
defense response to fungusGO:005083240.013
fatty acid derivative catabolic processGO:190156920.013
epithelial cell differentiationGO:00308551410.013
negative regulation of synaptic transmissionGO:005080520.013
cell matrix adhesionGO:0007160850.013
negative regulation of protein maturationGO:19033181420.013
regulation of protein transportGO:00512232130.013
quinone catabolic processGO:190166220.013
negative regulation of canonical wnt signaling pathwayGO:0090090550.013
negative regulation of protein modification processGO:00314002000.012
neuron projection developmentGO:00311751060.012
tissue morphogenesisGO:0048729960.012
embryonic epithelial tube formationGO:000183840.012
positive regulation of cell migrationGO:00303351720.012
protein targetingGO:00066051870.012
neuron developmentGO:00486661130.012
negative regulation of peptidase activityGO:0010466910.012
positive regulation of epithelial cell proliferation involved in wound healingGO:006005430.012
cellular response to organonitrogen compoundGO:00714171240.012
negative regulation of phosphorylationGO:00423261740.012
cellular cation homeostasisGO:00300031630.012
epoxygenase p450 pathwayGO:001937330.012
response to external biotic stimulusGO:00432072610.012
regulation of male gonad developmentGO:200001840.012
immune effector processGO:00022521590.012
myosin filament organizationGO:003103320.012
protein acylationGO:00435431380.012
non canonical wnt signaling pathway via mapk cascadeGO:003803040.012
negative regulation of gliogenesisGO:001401430.012
response to drugGO:0042493810.012
protein ubiquitinationGO:00165673140.012
carboxylic acid transportGO:0046942630.012
positive regulation of neural precursor cell proliferationGO:200017920.012
regulation of rho protein signal transductionGO:0035023790.012
long term memoryGO:000761620.012
adenylate cyclase inhibiting serotonin receptor signaling pathwayGO:000719820.012
positive regulation of aldosterone biosynthetic processGO:003234920.012
compound eye developmentGO:004874910.012
regulation of body fluid levelsGO:0050878990.012
anatomical structure homeostasisGO:00602491000.012
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.012
ubiquitin dependent protein catabolic processGO:00065112060.012
peptidyl lysine modificationGO:00182051440.012
regulation of sequence specific dna binding transcription factor activityGO:00510902110.012
hematopoietic or lymphoid organ developmentGO:00485341860.012
erk1 and erk2 cascadeGO:00703711040.012
dermatome developmentGO:006105430.012
regulation of reactive oxygen species metabolic processGO:2000377410.012

PRODH disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.050
inherited metabolic disorderDOID:6552420.041
musculoskeletal system diseaseDOID:172230.027
central nervous system diseaseDOID:3311860.023
nervous system diseaseDOID:8634310.023
disease of cellular proliferationDOID:145661740.023
cancerDOID:1621670.023
sensory system diseaseDOID:00501552030.022
organ system cancerDOID:00506861640.021
immune system diseaseDOID:29141550.019
muscular diseaseDOID:00800001140.014
eye and adnexa diseaseDOID:14921500.013
muscle tissue diseaseDOID:661130.013
amino acid metabolic disorderDOID:9252500.013
connective tissue diseaseDOID:651090.012
neurodegenerative diseaseDOID:12891020.012
cardiovascular system diseaseDOID:12871060.012