Homo sapiens

17 known processes

MAP3K12

mitogen-activated protein kinase kinase kinase 12

(Aliases: DLK,ZPK,MEKK12,ZPKP1,MUK)

MAP3K12 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of cellular ketone metabolic processGO:0010565500.167
cellular amino acid metabolic processGO:00065201160.158
cellular ketone metabolic processGO:0042180800.127
regulation of cellular amino acid metabolic processGO:000652160.114
negative regulation of apoptotic processGO:00430663160.101
hindbrain developmentGO:003090230.099
cell morphogenesisGO:00009022960.081
Fly
nervous system developmentGO:00073992930.071
Fly
positive regulation of cellular amine metabolic processGO:003324070.071
negative regulation of cellular amine metabolic processGO:003323930.070
regulation of cellular amine metabolic processGO:0033238110.067
positive regulation of protein phosphorylationGO:00019343130.063
Human Worm
amine metabolic processGO:0009308440.063
ameboidal type cell migrationGO:00016671350.061
cellular response to dna damage stimulusGO:00069743790.061
cellular amine metabolic processGO:0044106410.060
cell projection organizationGO:00300302520.059
Fly
positive regulation of cellular amino acid metabolic processGO:004576430.057
negative regulation of cell deathGO:00605483450.056
positive regulation of transportGO:00510503360.053
negative regulation of programmed cell deathGO:00430693210.052
maintenance of locationGO:00512351120.052
mitotic cell cycleGO:00002783260.050
negative regulation of cellular protein metabolic processGO:00322693530.050
regulation of cellular response to stressGO:00801352440.049
regulation of ion transmembrane transportGO:00347651320.047
positive regulation of cellular component organizationGO:00511303760.046
guanosine containing compound catabolic processGO:19010692390.045
sequestering of metal ionGO:0051238240.044
regulation of response to dna damage stimulusGO:2001020940.043
transmembrane transportGO:00550853990.043
ion transmembrane transportGO:00342203380.043
purine ribonucleoside catabolic processGO:00461303980.043
chemical homeostasisGO:00488783060.042
negative regulation of cellular amino acid metabolic processGO:004576320.042
regulation of locomotionGO:00400123290.042
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.042
post embryonic developmentGO:000979120.041
Worm
cellular homeostasisGO:00197251960.040
vesicle mediated transportGO:00161923710.040
negative regulation of catalytic activityGO:00430863350.039
regulation of transferase activityGO:00513383550.039
Human Worm
regulation of cell cycleGO:00517263930.039
neurogenesisGO:00220081690.039
Fly
lipid metabolic processGO:00066293810.039
glycosyl compound catabolic processGO:19016584130.038
morphogenesis of embryonic epitheliumGO:001633140.038
regulation of transmembrane transportGO:00347621390.038
enzyme linked receptor protein signaling pathwayGO:00071673030.037
cation homeostasisGO:00550801890.036
embryonic epithelial tube formationGO:000183840.036
negative regulation of transportGO:00510511760.036
actin cytoskeleton organizationGO:00300362070.036
ion homeostasisGO:00508012300.035
regulation of protein kinase activityGO:00458592890.035
Human Worm
regulation of cellular component movementGO:00512703340.035
lipid biosynthetic processGO:00086101770.035
regulation of cell motilityGO:20001452990.035
determination of adult lifespanGO:000834020.034
negative regulation of multicellular organismal processGO:00512413170.034
positive regulation of kinase activityGO:00336742040.034
Human Worm
positive regulation of nucleoside metabolic processGO:00459791860.033
regulation of nucleoside metabolic processGO:00091182090.033
tissue migrationGO:00901301190.033
response to oxygen containing compoundGO:19017003690.033
immune responseGO:00069553070.032
inorganic ion transmembrane transportGO:00986602310.032
cation transportGO:00068123310.032
mapk cascadeGO:00001652880.032
Human Worm
cytoplasmic transportGO:00164823790.032
female gamete generationGO:000729220.032
dephosphorylationGO:00163112090.032
epithelial cell migrationGO:00106311190.032
compound eye developmentGO:004874910.032
negative regulation of protein metabolic processGO:00512483910.031
cellular lipid metabolic processGO:00442553030.031
positive regulation of organelle organizationGO:00106381950.031
cellular component morphogenesisGO:00329893140.031
Fly
neuron differentiationGO:00301821380.031
Fly
metal ion transportGO:00300012720.031
regulation of ion transportGO:00432691890.030
generation of neuronsGO:00486991520.030
Fly
cellular chemical homeostasisGO:00550821800.030
metencephalon developmentGO:002203720.030
epithelium migrationGO:00901321190.030
system processGO:00030083490.029
circulatory system developmentGO:00723592620.029
cation transmembrane transportGO:00986552380.029
endocytosisGO:00068971590.029
regulation of cell differentiationGO:00455953930.029
positive regulation of cell deathGO:00109422630.029
regulation of epithelial cell migrationGO:0010632930.029
ribonucleoside triphosphate metabolic processGO:00091994120.029
purine ribonucleoside triphosphate metabolic processGO:00092054110.028
memoryGO:000761330.028
neuron developmentGO:00486661130.028
Fly
regulation of dna metabolic processGO:00510521530.028
positive regulation of phosphorylationGO:00423273940.028
Human Worm
regulation of cell migrationGO:00303342890.027
regulation of apoptotic signaling pathwayGO:20012331750.027
purine ribonucleotide catabolic processGO:00091544040.027
actin filament based processGO:00300292240.027
ribonucleoside triphosphate catabolic processGO:00092033910.026
purine nucleotide catabolic processGO:00061954050.026
apoptotic signaling pathwayGO:00971902680.026
divalent inorganic cation transportGO:00725111580.026
calcium ion transportGO:00068161470.026
positive regulation of protein kinase activityGO:00458601900.025
Human Worm
negative regulation of cellular component organizationGO:00511292350.025
positive regulation of purine nucleotide metabolic processGO:19005442270.025
calcium ion transmembrane transportGO:0070588760.025
regulation of protein localizationGO:00328802960.024
purine ribonucleoside metabolic processGO:00461284370.024
negative regulation of phosphate metabolic processGO:00459362670.024
microtubule based processGO:00070172100.024
purine nucleoside triphosphate catabolic processGO:00091463920.024
neural tube formationGO:000184130.024
negative regulation of phosphorylationGO:00423261740.024
cellular metal ion homeostasisGO:00068751460.024
positive regulation of transferase activityGO:00513472270.024
Human Worm
covalent chromatin modificationGO:00165692540.024
Mouse
regulation of nucleotide metabolic processGO:00061402690.023
cell developmentGO:00484683280.023
Fly
inorganic cation transmembrane transportGO:00986621940.023
negative regulation of phosphorus metabolic processGO:00105632670.023
associative learningGO:000830610.023
positive regulation of cell proliferationGO:00082843010.023
cellular response to endogenous stimulusGO:00714953360.023
chromatin organizationGO:00063253510.023
Mouse
neurological system processGO:00508771630.023
anatomical structure formation involved in morphogenesisGO:00486462840.023
cell growthGO:00160491600.023
Fly
protein ubiquitinationGO:00165673140.023
cerebellum developmentGO:002154920.023
positive regulation of mapk cascadeGO:00434101900.023
Human Worm
signal transduction by phosphorylationGO:00230142970.022
Human Worm
defense responseGO:00069523150.022
nucleoside triphosphate metabolic processGO:00091414220.022
g protein coupled receptor signaling pathwayGO:00071862070.022
positive regulation of locomotionGO:00400171860.022
peripheral nervous system developmentGO:000742220.022
forebrain generation of neuronsGO:002187230.022
multicellular organismal response to stressGO:003355510.021
cellular ion homeostasisGO:00068731680.021
organophosphate catabolic processGO:00464344300.021
oogenesisGO:004847720.021
response to hormoneGO:00097251750.021
negative regulation of protein modification processGO:00314002000.021
cell projection morphogenesisGO:00488581290.021
Fly
negative regulation of cell proliferationGO:00082852280.021
calcium ion homeostasisGO:00550741220.021
mitotic cell cycle processGO:19030472860.021
multicellular organismal agingGO:001025930.021
single organism cellular localizationGO:19025803320.020
neuroblast proliferationGO:000740540.020
innate immune responseGO:00450871780.020
divalent metal ion transportGO:00708381520.020
reactive nitrogen species metabolic processGO:200105730.020
organophosphate biosynthetic processGO:00904071630.020
brain developmentGO:0007420970.020
protein modification by small protein conjugationGO:00324463420.020
positive regulation of hydrolase activityGO:00513453310.020
nucleoside triphosphate catabolic processGO:00091433940.020
ribonucleotide catabolic processGO:00092614050.020
regulation of cell cycle processGO:00105642660.020
secretionGO:00469032540.020
regulation of purine nucleotide catabolic processGO:00331212050.020
intracellular protein transportGO:00068862700.019
endothelial cell migrationGO:0043542860.019
dna repairGO:00062811980.019
cell part morphogenesisGO:00329901370.019
Fly
reactive oxygen species biosynthetic processGO:190340940.019
lipid transportGO:0006869900.019
head developmentGO:00603221080.019
sequestering of calcium ionGO:0051208170.019
regulation of transporter activityGO:0032409820.019
response to lipidGO:00339932060.019
negative regulation of cell differentiationGO:00455961710.019
regulation of transmembrane transporter activityGO:0022898740.019
regulation of calcium ion transportGO:0051924790.019
vasculature developmentGO:00019441810.019
positive regulation of developmental processGO:00510943140.019
positive regulation of programmed cell deathGO:00430682490.019
negative regulation of protein phosphorylationGO:00019331400.019
regulation of endothelial cell migrationGO:0010594670.018
regulation of gtp catabolic processGO:00331241800.018
neuromuscular junction developmentGO:000752830.018
regulation of nucleotide catabolic processGO:00308112050.018
regulation of protein modification by small protein conjugation or removalGO:19033201070.018
regulation of sequence specific dna binding transcription factor activityGO:00510902110.018
Human
organonitrogen compound biosynthetic processGO:19015662000.018
negative regulation of intracellular signal transductionGO:19025321830.018
positive regulation of catabolic processGO:00098963100.018
regulation of cytoplasmic transportGO:19036491490.018
cell projection assemblyGO:00300311260.018
negative regulation of transferase activityGO:00513481240.018
negative regulation of kinase activityGO:00336731060.018
organelle assemblyGO:00709251760.018
nucleoside phosphate catabolic processGO:19012924120.018
peptidyl tyrosine phosphorylationGO:00181081700.018
cardiovascular system developmentGO:00723582620.018
negative regulation of epithelial cell migrationGO:0010633380.018
glycerolipid metabolic processGO:00464861070.018
positive regulation of nucleotide catabolic processGO:00308131850.018
negative regulation of cell cycleGO:00457861930.017
regulation of protein serine threonine kinase activityGO:00719001790.017
Human Worm
blood vessel developmentGO:00015681720.017
peptidyl lysine modificationGO:00182051440.017
cellular protein catabolic processGO:00442572610.017
rab protein signal transductionGO:003248240.017
positive regulation of ion transportGO:0043270870.017
gtp catabolic processGO:00061842370.017
response to organic cyclic compoundGO:00140702040.017
fatty acid metabolic processGO:00066311150.017
axon cargo transportGO:000808820.017
protein catabolic processGO:00301633250.017
negative regulation of developmental processGO:00510932470.017
phospholipid metabolic processGO:0006644990.017
positive regulation of gtp catabolic processGO:00331261660.017
neuron projection developmentGO:00311751060.017
Fly
regulation of mitotic cell cycleGO:00073461890.017
glycerolipid biosynthetic processGO:0045017510.017
ubiquitin dependent protein catabolic processGO:00065112060.017
positive regulation of cell migrationGO:00303351720.016
regulation of establishment of protein localizationGO:00702012420.016
regulation of metal ion transportGO:00109591200.016
adult locomotory behaviorGO:000834410.016
cellular cation homeostasisGO:00300031630.016
regenerationGO:003109940.016
Fly
regulation of lipid metabolic processGO:0019216960.016
regulation of cytoskeleton organizationGO:00514931770.016
oxidation reduction processGO:00551143960.016
protein localization to organelleGO:00333652800.016
nuclear migrationGO:000709710.016
organic hydroxy compound metabolic processGO:19016151470.016
actin filament organizationGO:00070151280.016
purine nucleoside triphosphate metabolic processGO:00091444120.016
glial cell migrationGO:000834740.016
regulation of anatomical structure morphogenesisGO:00226032860.016
nuclear transportGO:00511691790.016
regulation of vesicle mediated transportGO:00606271300.016
regulation of cell growthGO:00015581350.016
positive regulation of purine nucleotide catabolic processGO:00331231850.016
wnt signaling pathwayGO:00160551560.016
peptidyl tyrosine modificationGO:00182121700.016
limbic system developmentGO:002176130.016
membrane organizationGO:00610242920.015
nitrogen compound transportGO:00717051910.015
central nervous system developmentGO:00074171230.015
small molecule biosynthetic processGO:00442831570.015
regulation of intracellular transportGO:00323861950.015
neurotransmitter secretionGO:000726940.015
ribonucleoside catabolic processGO:00424544060.015
cell type specific apoptotic processGO:00972851250.015
purine ribonucleoside triphosphate catabolic processGO:00092073910.015
regulation of mapk cascadeGO:00434082620.015
Human Worm
chromatin modificationGO:00165682980.015
Mouse
regulation of reactive oxygen species biosynthetic processGO:190342630.015
secretion by cellGO:00329402260.015
regulation of ion transmembrane transporter activityGO:0032412720.015
protein maturationGO:00516042330.015
positive regulation of protein serine threonine kinase activityGO:00719021190.015
Human Worm
single organism membrane organizationGO:00448022680.015
negative regulation of cell motilityGO:20001461040.015
negative regulation of cellular component movementGO:00512711060.015
regulation of multi organism processGO:00439001570.015
positive regulation of cellular component biogenesisGO:00440891580.015
regulation of bindingGO:00510981110.015
rna interferenceGO:001624640.015
cell morphogenesis involved in differentiationGO:00009041440.015
Fly
peptidyl threonine phosphorylationGO:0018107410.014
Mouse
regulation of kinase activityGO:00435493140.014
Human Worm
regulation of proteolysisGO:00301622930.014
cholesterol transportGO:0030301390.014
regulation of actin filament based processGO:00329701410.014
establishment of protein localization to organelleGO:00725941720.014
epithelium developmentGO:00604292270.014
positive regulation of cellular catabolic processGO:00313312840.014
lipid modificationGO:0030258840.014
syncytium formation by plasma membrane fusionGO:000076820.014
nuclear importGO:00511701060.014
regulation of homeostatic processGO:00328441210.014
regulation of map kinase activityGO:00434051080.014
Human Worm
protein targetingGO:00066051870.014
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.014
regulation of protein polymerizationGO:0032271630.014
motor neuron axon guidanceGO:000804520.014
defense response to other organismGO:00985421290.014
monocarboxylic acid metabolic processGO:00327871850.014
proteolysis involved in cellular protein catabolic processGO:00516032440.014
muscle system processGO:0003012810.014
cellular protein complex assemblyGO:00436231880.014
negative regulation of t cell apoptotic processGO:007023340.014
endosomal transportGO:00161971290.014
carbohydrate derivative biosynthetic processGO:19011372070.014
cell cycle phase transitionGO:00447701730.014
protein localization to nucleusGO:00345041360.013
defense response to bacteriumGO:0042742630.013
response to external biotic stimulusGO:00432072610.013
regulation of neurogenesisGO:0050767820.013
regulation of protein ubiquitinationGO:0031396950.013
blastoderm segmentationGO:000735020.013
segmentationGO:003528240.013
chemotaxisGO:00069351570.013
regulation of reactive oxygen species metabolic processGO:2000377410.013
purine nucleoside catabolic processGO:00061523980.013
response to other organismGO:00517072610.013
negative regulation of apoptotic signaling pathwayGO:2001234970.013
regulation of dephosphorylationGO:0035303960.013
response to abiotic stimulusGO:00096283360.013
lipid localizationGO:00108761060.013
peptidyl serine modificationGO:00182091060.013
Mouse
small gtpase mediated signal transductionGO:0007264780.013
rho protein signal transductionGO:0007266260.013
peptidyl threonine modificationGO:0018210450.013
Mouse
ras protein signal transductionGO:0007265730.013
regulation of cell developmentGO:00602841610.013
regulation of growthGO:00400081650.013
melanin metabolic processGO:000658210.013
regulation of neural precursor cell proliferationGO:200017740.013
regulation of neuron differentiationGO:0045664700.013
organic hydroxy compound transportGO:0015850630.013
fear responseGO:004259600.013
positive regulation of reactive oxygen species biosynthetic processGO:190342820.013
growthGO:00400072020.013
Fly
carbohydrate transportGO:0008643370.013
positive regulation of gliogenesisGO:001401540.013
negative regulation of cell cycle processGO:00109481210.013
response to nitrogen compoundGO:19016981840.013
negative regulation of canonical wnt signaling pathwayGO:0090090550.013
matingGO:000761810.012
locomotory behaviorGO:000762610.012
divalent inorganic cation homeostasisGO:00725071360.012
positive regulation of protein transportGO:00512221350.012
mitotic nuclear divisionGO:00070671190.012
regulation of wnt signaling pathwayGO:00301111230.012
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.012
Human
metal ion homeostasisGO:00550651690.012
spindle elongationGO:005123140.012
protein acylationGO:00435431380.012
positive regulation of epithelial cell proliferationGO:0050679650.012
engulfment of apoptotic cellGO:004365220.012
morphogenesis of a polarized epitheliumGO:000173830.012
nucleocytoplasmic transportGO:00069131760.012
positive regulation of cytoskeleton organizationGO:0051495830.012
cell cycle checkpointGO:00000751170.012
photoreceptor cell differentiationGO:004653020.012
regulation of protein processingGO:00706131500.012
activation of protein kinase activityGO:0032147900.012
Human Worm
positive regulation of nf kappab transcription factor activityGO:0051092810.012
Human
endomembrane system organizationGO:00102561960.012
Fly
positive regulation of cytokine productionGO:00018191670.012
cellular macromolecular complex assemblyGO:00346223240.012
regulation of purine nucleotide metabolic processGO:19005422640.011
regulation of glial cell proliferationGO:006025140.011
iron ion homeostasisGO:0055072150.011
lipid catabolic processGO:0016042840.011
regulation of neurotransmitter secretionGO:004692830.011
positive regulation of reactive oxygen species metabolic processGO:2000379240.011
behavioral defense responseGO:000220900.011
nucleoside phosphate biosynthetic processGO:19012931090.011
regulation of immune responseGO:00507762010.011
positive regulation of cell motilityGO:20001471770.011
oocyte developmentGO:004859910.011
negative regulation of cell migrationGO:00303361020.011
cellular lipid catabolic processGO:0044242650.011
nucleotide catabolic processGO:00091664080.011
response to inorganic substanceGO:00100351270.011
establishment of nucleus localizationGO:004002310.011
circulatory system processGO:00030131130.011
regulation of protein maturationGO:19033171500.011
positive regulation of endothelial cell migrationGO:0010595390.011
negative regulation of organelle organizationGO:00106391260.011
axon regenerationGO:003110310.011
Fly
forebrain neuron differentiationGO:002187930.011
tissue regenerationGO:004224630.011
carboxylic acid catabolic processGO:0046395710.011
muscle cell fate commitmentGO:004269340.011
protein processingGO:00164852260.011
protein methylationGO:0006479740.011
regulation of angiogenesisGO:0045765920.011
positive regulation of cell differentiationGO:00455972110.011
negative regulation of protein kinase activityGO:0006469980.011
regulation of innate immune responseGO:0045088970.011
negative regulation of protein serine threonine kinase activityGO:0071901570.011
positive regulation of gtpase activityGO:00435471660.011
purine containing compound catabolic processGO:00725234110.011
phosphatidylinositol mediated signalingGO:0048015550.011
small molecule catabolic processGO:0044282920.011
regulation of peptidase activityGO:00525471800.011
regulation of phosphatase activityGO:0010921810.011
ribonucleotide biosynthetic processGO:0009260810.011
oocyte differentiationGO:000999420.011
taxisGO:00423301570.011
regulation of oxidoreductase activityGO:0051341430.011
modification dependent macromolecule catabolic processGO:00436322120.011
cellular calcium ion homeostasisGO:00068741170.011
protein localization to membraneGO:00726571600.011
response to cytokineGO:00340972320.011
epithelial cell proliferationGO:00506731280.011
positive regulation of ras gtpase activityGO:00323201170.011
long term memoryGO:000761620.011
mechanosensory behaviorGO:000763840.011
response to growth factorGO:00708482050.011
regulation of high density lipoprotein particle clearanceGO:001098220.011
establishment or maintenance of apical basal cell polarityGO:003508820.011
histone acetylationGO:0016573930.011
response to organonitrogen compoundGO:00102431560.011
anion transportGO:00068201610.011
negative regulation of growthGO:0045926970.011
cellular response to abiotic stimulusGO:00712141170.010
actin polymerization or depolymerizationGO:0008154560.010
visual learningGO:000854210.010
cellular response to cytokine stimulusGO:00713451810.010
organic acid transportGO:0015849650.010
establishment or maintenance of bipolar cell polarityGO:006124520.010
establishment of organelle localizationGO:0051656590.010
protein acetylationGO:00064731160.010
establishment of protein localization to plasma membraneGO:0090002680.010
protein autophosphorylationGO:00467771230.010
Human Mouse
multi organism cellular processGO:00447641560.010
spinal cord developmentGO:002151040.010
positive regulation of apoptotic processGO:00430652460.010
positive regulation of map kinase activityGO:0043406800.010
Human Worm
regulation of cell projection organizationGO:00313441070.010
tripartite regional subdivisionGO:000735120.010
response to axon injuryGO:004867810.010
Fly
cellular response to oxygen containing compoundGO:19017012760.010
regulation of vasculature developmentGO:1901342970.010

MAP3K12 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:8634310.034
central nervous system diseaseDOID:3311860.034
disease of metabolismDOID:00146672950.029
sensory system diseaseDOID:00501552030.020
cancerDOID:1621670.016
disease of cellular proliferationDOID:145661740.016
organ system cancerDOID:00506861640.016
neurodegenerative diseaseDOID:12891020.013
inherited metabolic disorderDOID:6552420.012
musculoskeletal system diseaseDOID:172230.010