Homo sapiens

121 known processes

SYK

spleen tyrosine kinase

(Aliases: DKFZp313N1010,FLJ25043,FLJ37489)

SYK biological process predictions


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Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of myeloid leukocyte mediated immunityGO:000288641.000
Mouse Rat
leukocyte activationGO:00453211641.000
Human Mouse Rat
menstrual cycle phaseGO:002260121.000
regulation of humoral immune response mediated by circulating immunoglobulinGO:000292331.000
lymphocyte activationGO:00466491331.000
Human Mouse
cell activationGO:00017752130.999
Human Mouse Rat
mast cell activation involved in immune responseGO:000227940.999
Mouse Rat
amine metabolic processGO:0009308440.999
regulation of cellular amine metabolic processGO:0033238110.999
positive regulation of cellular amine metabolic processGO:003324070.999
cell chemotaxisGO:00603261120.999
regulation of acute inflammatory response to antigenic stimulusGO:000286410.999
positive regulation of cell proliferationGO:00082843010.999
Mouse
regulation of cellular amino acid metabolic processGO:000652160.999
positive regulation of myeloid leukocyte mediated immunityGO:000288810.998
Mouse Rat
regulation of cell cell adhesionGO:0022407570.998
Mouse
regulation of leukocyte activationGO:00026941150.998
Human Mouse Rat
positive regulation of alpha beta t cell proliferationGO:004664150.998
Mouse
positive regulation of mast cell activationGO:003300520.997
Mouse Rat
positive regulation of phosphorylationGO:00423273940.997
Mouse
phagocytosis recognitionGO:000691030.997
negative regulation of leukocyte apoptotic processGO:2000107160.996
regulation of cell activationGO:00508651250.996
Human Mouse Rat
positive regulation of leukocyte activationGO:0002696800.996
Human Mouse Rat
regulation of hemostasisGO:1900046420.996
Mouse
myeloid leukocyte activationGO:0002274340.996
Mouse Rat
mononuclear cell proliferationGO:0032943710.996
Mouse
leukocyte proliferationGO:0070661740.996
Mouse
regulation of peptidyl tyrosine phosphorylationGO:00507301080.996
Mouse
positive regulation of immunoglobulin mediated immune responseGO:000289140.996
t cell receptor signaling pathwayGO:0050852210.995
positive regulation of protein kinase b signalingGO:0051897420.995
regulation of blood coagulationGO:0030193420.995
Mouse
monoamine transportGO:0015844100.994
Mouse
fc receptor signaling pathwayGO:003809320.994
regulation of cytokine productionGO:00018172320.994
Mouse
nerve developmentGO:002167540.994
negative regulation of homeostatic processGO:0032845590.993
cellular amino acid metabolic processGO:00065201160.993
immune response activating signal transductionGO:0002757900.992
Mouse
negative regulation of apoptotic processGO:00430663160.991
mast cell degranulationGO:004330340.991
Mouse Rat
anatomical structure formation involved in morphogenesisGO:00486462840.991
Zebrafish Fly
epithelial cell migrationGO:00106311190.989
Zebrafish
divalent inorganic cation homeostasisGO:00725071360.989
chemotaxisGO:00069351570.988
positive regulation of acute inflammatory responseGO:000267520.988
positive regulation of cytokine productionGO:00018191670.988
Mouse
tumor necrosis factor superfamily cytokine productionGO:0071706450.987
negative regulation of cell deathGO:00605483450.985
enzyme linked receptor protein signaling pathwayGO:00071673030.984
Mouse
leukocyte chemotaxisGO:0030595760.984
immune response activating cell surface receptor signaling pathwayGO:0002429450.983
Mouse
t cell activationGO:0042110990.983
Human Mouse
cellular ketone metabolic processGO:0042180800.982
positive regulation of phosphatidylinositol 3 kinase signalingGO:0014068280.982
response to growth factorGO:00708482050.982
regulation of epithelial cell migrationGO:0010632930.981
Zebrafish
regulation of immune responseGO:00507762010.981
Mouse Rat
activation of immune responseGO:00022531140.980
Mouse
positive regulation of phagocytosisGO:0050766150.979
neutrophil migrationGO:1990266250.978
positive regulation of leukocyte degranulationGO:004330230.976
Mouse Rat
cation homeostasisGO:00550801890.974
acute inflammatory response to antigenic stimulusGO:000243810.974
positive regulation of interferon gamma mediated signaling pathwayGO:006033520.973
tyrosine phosphorylation of stat proteinGO:0007260330.973
hemopoiesisGO:00300971800.972
Human Mouse
leukocyte migrationGO:00509001070.971
cellular homeostasisGO:00197251960.970
single organismal cell cell adhesionGO:00163371480.969
lymphocyte proliferationGO:0046651700.969
Mouse
metal ion homeostasisGO:00550651690.969
positive regulation of cell activationGO:0050867810.968
Human Mouse Rat
wound healingGO:00420601150.965
Mouse
positive regulation of b cell mediated immunityGO:000271440.963
phospholipid metabolic processGO:0006644990.961
peptidyl tyrosine modificationGO:00182121700.961
regulation of leukocyte proliferationGO:0070663670.960
Mouse
positive regulation of leukocyte mediated immunityGO:0002705240.960
Mouse Rat
positive regulation of cellular component organizationGO:00511303760.958
negative regulation of myeloid cell apoptotic processGO:003303340.954
cellular response to growth factor stimulusGO:00713631970.953
regulation of ion homeostasisGO:2000021730.951
tyrosine phosphorylation of stat5 proteinGO:0042506130.950
antigen receptor mediated signaling pathwayGO:0050851380.948
Mouse
biological adhesionGO:00226103310.946
positive regulation of lipid kinase activityGO:0090218130.945
positive regulation of immune responseGO:00507781590.945
Mouse Rat
cation transportGO:00068123310.944
Mouse
regulation of leukocyte mediated immunityGO:0002703380.941
Mouse Rat
cellular amine metabolic processGO:0044106410.941
nitrogen compound transportGO:00717051910.936
Mouse
regulation of b cell mediated immunityGO:000271270.935
negative regulation of homotypic cell cell adhesionGO:003411130.935
regulation of cytokine biosynthetic processGO:0042035350.933
Mouse
regulation of leukocyte apoptotic processGO:2000106250.930
positive regulation of endothelial cell migrationGO:0010595390.929
Zebrafish
positive regulation of map kinase activityGO:0043406800.927
Mouse
immune system developmentGO:00025201950.926
Human Mouse
positive regulation of immune system processGO:00026842830.926
Human Mouse Rat
negative regulation of programmed cell deathGO:00430693210.925
regulation of protein serine threonine kinase activityGO:00719001790.924
Mouse
regulation of cellular ketone metabolic processGO:0010565500.921
regulation of body fluid levelsGO:0050878990.921
Mouse
positive regulation of leukocyte proliferationGO:0070665480.920
Mouse
cellular lipid metabolic processGO:00442553030.917
Mouse
cytokine productionGO:00018162470.916
Mouse
leukocyte apoptotic processGO:0071887310.914
neutrophil activation involved in immune responseGO:000228330.914
Mouse
actin filament organizationGO:00070151280.912
positive regulation of exocytosisGO:0045921350.911
Mouse Rat
positive regulation of t cell proliferationGO:0042102330.909
Mouse
neuron projection developmentGO:00311751060.908
Fly
platelet activationGO:0030168440.899
Mouse
jak stat cascadeGO:0007259460.899
positive regulation of protein kinase activityGO:00458601900.898
Mouse
positive regulation of lymphocyte activationGO:0051251730.896
Human Mouse
cellular divalent inorganic cation homeostasisGO:00725031280.895
b cell receptor signaling pathwayGO:0050853180.893
Mouse
phosphatidylinositol mediated signalingGO:0048015550.891
b cell activationGO:0042113330.891
Mouse
positive regulation of cytokine mediated signaling pathwayGO:0001961120.889
regulation of mononuclear cell proliferationGO:0032944650.888
Mouse
positive regulation of locomotionGO:00400171860.885
Zebrafish
cell type specific apoptotic processGO:00972851250.880
regulation of cell adhesionGO:00301551660.880
Mouse
serotonin secretionGO:000182010.880
Mouse
organelle localizationGO:0051640840.878
Mouse Rat
regulation of t cell activationGO:0050863770.877
Human Mouse
calcium ion homeostasisGO:00550741220.867
response to woundingGO:00096111680.866
Mouse
regulation of lymphocyte proliferationGO:0050670640.864
Mouse
calcium mediated signalingGO:0019722440.864
Mouse
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822290.864
regulation of intracellular transportGO:00323861950.862
Mouse Rat
cellular ion homeostasisGO:00068731680.859
regulation of cell migrationGO:00303342890.857
Zebrafish
vesicle mediated transportGO:00161923710.854
Mouse Rat Fly
t cell selectionGO:004505840.854
Human Mouse
regulation of sequestering of calcium ionGO:0051282410.851
regulation of immunoglobulin mediated immune responseGO:000288970.851
myeloid leukocyte migrationGO:0097529620.843
actin filament bundle organizationGO:0061572540.840
regulation of response to external stimulusGO:00321012220.835
Mouse
maintenance of locationGO:00512351120.827
positive regulation of lymphocyte proliferationGO:0050671460.825
Mouse
taxisGO:00423301570.820
cell projection organizationGO:00300302520.815
Fly
mast cell activationGO:004557660.813
Mouse Rat
regulation of mast cell activation involved in immune responseGO:003300630.813
Mouse Rat
positive regulation of regulated secretory pathwayGO:190330780.810
Mouse Rat
positive regulation of endocytosisGO:0045807420.809
positive regulation of kinase activityGO:00336742040.808
Mouse
membrane organizationGO:00610242920.805
oogenesisGO:004847720.803
Fly
multicellular organismal agingGO:001025930.799
positive regulation of tumor necrosis factor superfamily cytokine productionGO:1903557220.794
positive regulation of intrinsic apoptotic signaling pathwayGO:2001244280.789
positive regulation of protein phosphorylationGO:00019343130.784
Mouse
positive regulation of cellular amino acid metabolic processGO:004576430.778
negative regulation of cell activationGO:0050866330.775
cytokine biosynthetic processGO:0042089370.773
Mouse
granulocyte migrationGO:0097530400.773
cellular chemical homeostasisGO:00550821800.768
granulocyte chemotaxisGO:0071621370.767
positive regulation of lipid metabolic processGO:0045834500.766
metal ion transportGO:00300012720.763
regulation of immune effector processGO:0002697910.762
Mouse Rat
endoderm formationGO:0001706330.759
azole transportGO:004511740.759
positive regulation of cytosolic calcium ion concentrationGO:0007204820.758
lipid metabolic processGO:00066293810.758
Mouse
positive regulation of intracellular transportGO:00323881040.757
Mouse Rat
positive regulation of interferon gamma productionGO:0032729260.756
b cell mediated immunityGO:0019724100.755
leukocyte activation involved in immune responseGO:0002366300.753
Mouse Rat
regulation of lymphocyte activationGO:00512491030.751
Human Mouse
regulation of anatomical structure morphogenesisGO:00226032860.749
Zebrafish Fly
tyrosine phosphorylation of stat3 proteinGO:0042503200.749
regulation of tumor necrosis factor superfamily cytokine productionGO:1903555440.749
thymic t cell selectionGO:004506120.748
Human
regulation of lipid kinase activityGO:0043550190.746
positive regulation of adaptive immune responseGO:0002821210.745
cell activation involved in immune responseGO:0002263300.744
Mouse Rat
inositol lipid mediated signalingGO:0048017550.743
divalent inorganic cation transportGO:00725111580.742
regulation of mast cell activationGO:003300350.733
Mouse Rat
cellular component morphogenesisGO:00329893140.733
Fly
leukocyte differentiationGO:0002521980.732
Human Mouse
hematopoietic or lymphoid organ developmentGO:00485341860.730
Human Mouse
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.730
granulocyte activationGO:0036230100.729
Mouse
single organism cellular localizationGO:19025803320.727
regulation of cell projection organizationGO:00313441070.725
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.722
exocytosisGO:0006887710.712
Mouse Rat
positive regulation of immune effector processGO:0002699400.710
Mouse Rat
endodermal cell fate commitmentGO:000171140.705
regulation of phagocytosisGO:0050764210.702
Mouse
cellular metal ion homeostasisGO:00068751460.698
negative regulation of platelet aggregationGO:009033130.695
interferon gamma productionGO:0032609390.683
protein kinase b signalingGO:0043491690.683
behaviorGO:00076101120.680
negative regulation of multicellular organismal processGO:00512413170.680
organic hydroxy compound transportGO:0015850630.677
Mouse
negative regulation of b cell mediated immunityGO:000271330.676
cell developmentGO:00484683280.675
Fly
positive regulation of tyrosine phosphorylation of stat5 proteinGO:0042523110.673
regulation of cell motilityGO:20001452990.673
Zebrafish
positive regulation of transportGO:00510503360.662
Mouse Rat
leukocyte mediated immunityGO:0002443590.661
Mouse Rat
ameboidal type cell migrationGO:00016671350.659
Zebrafish
dephosphorylationGO:00163112090.653
response to bacteriumGO:00096171440.652
Mouse
negative regulation of anoikisGO:2000811150.651
response to transforming growth factor betaGO:0071559940.649
inflammatory response to antigenic stimulusGO:000243740.648
immunoglobulin mediated immune responseGO:0016064100.645
cellular response to dna damage stimulusGO:00069743790.637
positive regulation of t cell activationGO:0050870540.634
Human Mouse
response to other organismGO:00517072610.633
Mouse
regulation of adaptive immune responseGO:0002819330.632
peptidyl tyrosine dephosphorylationGO:0035335360.632
mast cell mediated immunityGO:000244850.626
Mouse Rat
immune response regulating cell surface receptor signaling pathwayGO:0002768510.621
Mouse
regulation of homeostatic processGO:00328441210.620
Mouse
response to lipidGO:00339932060.619
positive regulation of tumor necrosis factor productionGO:0032760210.610
negative regulation of humoral immune responseGO:000292170.608
positive regulation of jak stat cascadeGO:0046427350.607
peptidyl serine phosphorylationGO:00181051010.601
Mouse
regulation of calcium ion transportGO:0051924790.595
antigen processing and presentation of exogenous peptide antigenGO:000247840.594
cellular response to oxygen containing compoundGO:19017012760.592
ion homeostasisGO:00508012300.589
regulation of apoptotic signaling pathwayGO:20012331750.583
regulation of wound healingGO:0061041560.577
Mouse
actin cytoskeleton organizationGO:00300362070.577
regulation of interferon gamma productionGO:0032649360.575
positive regulation of secretion by cellGO:19035321080.574
Mouse Rat
regulation of cellular component movementGO:00512703340.569
Zebrafish
innate immune responseGO:00450871780.564
Mouse
positive regulation of calcium mediated signalingGO:0050850100.563
Mouse
cellular response to endogenous stimulusGO:00714953360.559
negative regulation of peptidyl tyrosine phosphorylationGO:0050732200.557
negative regulation of coagulationGO:0050819240.555
positive regulation of tyrosine phosphorylation of stat proteinGO:0042531280.547
regulation of cell developmentGO:00602841610.547
positive regulation of neuron differentiationGO:0045666400.544
hemostasisGO:0007599760.537
Mouse
anoikisGO:0043276220.537
antigen processing and presentation of peptide antigen via mhc class iiGO:0002495110.534
cellular response to lipidGO:00713961270.531
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000282380.529
phagocytosisGO:0006909420.522
Mouse Fly
negative regulation of phosphate metabolic processGO:00459362670.522
stress fiber assemblyGO:0043149400.519
regulation of podosome assemblyGO:007180150.518
apoptotic signaling pathwayGO:00971902680.517
myeloid leukocyte mediated immunityGO:0002444100.515
Mouse Rat
regulation of neuron differentiationGO:0045664700.513
response to organic cyclic compoundGO:00140702040.512
tumor necrosis factor productionGO:0032640430.511
female gamete generationGO:000729220.506
Fly
negative regulation of blood coagulationGO:0030195220.505
endodermal cell fate specificationGO:000171440.504
regulation of mast cell degranulationGO:004330430.503
Mouse Rat
positive regulation of peptidyl tyrosine phosphorylationGO:0050731850.502
Mouse
cytokine metabolic processGO:0042107380.496
Mouse
regulation of neutrophil apoptotic processGO:003302910.494
actin filament based processGO:00300292240.488
cellular response to transforming growth factor beta stimulusGO:0071560940.488
myeloid cell activation involved in immune responseGO:0002275100.485
Mouse Rat
regulation of tyrosine phosphorylation of stat proteinGO:0042509300.484
coagulationGO:0050817780.478
Mouse
immune effector processGO:00022521590.477
Mouse Rat
negative regulation of adaptive immune responseGO:000282090.471
regulation of cytokine mediated signaling pathwayGO:0001959410.468
adaptive immune responseGO:0002250490.467
neuron projection morphogenesisGO:0048812500.464
Fly
regulation of b cell proliferationGO:0030888180.459
release of sequestered calcium ion into cytosolGO:0051209410.456
production of molecular mediator of immune responseGO:0002440370.454
dna replicationGO:00062601160.450
homeostasis of number of cellsGO:0048872400.449
positive regulation of developmental processGO:00510943140.444
Human Zebrafish Mouse
cytoplasmic transportGO:00164823790.443
negative regulation of protein homooligomerizationGO:003246340.442
cellular calcium ion homeostasisGO:00068741170.439
regulation of defense responseGO:00313471540.431
endocytosisGO:00068971590.428
Mouse Fly
neutrophil apoptotic processGO:000178120.425
transforming growth factor beta receptor signaling pathwayGO:0007179760.421
negative regulation of response to woundingGO:1903035470.418
integrin mediated signaling pathwayGO:0007229320.417
Mouse
antigen processing and presentation of peptide antigenGO:0048002180.414
neuron developmentGO:00486661130.411
Fly
chemical homeostasisGO:00488783060.411
regulation of protein localizationGO:00328802960.407
Mouse
negative regulation of protein phosphorylationGO:00019331400.406
regulation of locomotionGO:00400123290.405
Zebrafish
regulation of mitotic cell cycleGO:00073461890.405
negative regulation of wound healingGO:0061045250.404
neuromuscular junction developmentGO:000752830.403
positive regulation of cellular component movementGO:00512721810.398
Zebrafish
tissue migrationGO:00901301190.396
Zebrafish
positive regulation of inflammatory responseGO:0050729100.395
response to biotic stimulusGO:00096072760.395
Mouse
regulation of alpha beta t cell activationGO:0046634130.394
Mouse
regulation of lipid metabolic processGO:0019216960.392
negative regulation of phagocytosisGO:005076540.391
startle responseGO:000196430.390
negative regulation of cellular amine metabolic processGO:003323930.390
agingGO:0007568660.387
regulation of cell differentiationGO:00455953930.384
Human Mouse
positive regulation of response to external stimulusGO:0032103880.383
lipid biosynthetic processGO:00086101770.382
Mouse
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280690.381
negative regulation of transportGO:00510511760.381
positive regulation of epithelial cell migrationGO:0010634550.379
Zebrafish
regulation of actin cytoskeleton organizationGO:00329561160.376
regulation of protein kinase b signalingGO:0051896610.374
positive regulation of neuron projection developmentGO:0010976340.368
regulation of transferase activityGO:00513383550.367
Mouse
epithelium migrationGO:00901321190.367
Zebrafish
regulation of mitochondrial membrane potentialGO:0051881230.364
b cell proliferationGO:0042100220.361
cytokine mediated signaling pathwayGO:00192211090.361
regulation of reactive oxygen species metabolic processGO:2000377410.359
Mouse
salivary gland morphogenesisGO:000743540.358
regulation of acute inflammatory responseGO:0002673130.353
regulation of cell morphogenesisGO:00226041530.353
Fly
neutrophil chemotaxisGO:0030593240.353
formation of primary germ layerGO:0001704420.351
cytosolic calcium ion homeostasisGO:0051480890.351
regulation of actin filament based processGO:00329701410.348
humoral immune responseGO:0006959490.347
secretionGO:00469032540.347
Mouse Rat
establishment of cell polarityGO:0030010220.346
antigen processing and presentation of exogenous antigenGO:001988440.345
t cell proliferationGO:0042098450.340
Mouse
regulation of release of sequestered calcium ion into cytosolGO:0051279270.337
cranial nerve developmentGO:002154540.331
intrinsic apoptotic signaling pathwayGO:00971931270.330
regulation of coagulationGO:0050818440.329
Mouse
associative learningGO:000830610.328
protein autophosphorylationGO:00467771230.327
Mouse Rat
negative regulation of phosphorus metabolic processGO:00105632670.325
neurological system processGO:00508771630.323
immune response regulating signaling pathwayGO:0002764970.323
Mouse
peptide transportGO:0015833740.321
protein localization to membraneGO:00726571600.317
second messenger mediated signalingGO:0019932780.316
Mouse
neuron differentiationGO:00301821380.316
Fly
negative regulation of cysteine type endopeptidase activityGO:2000117480.316
negative regulation of protein oligomerizationGO:003246080.315
defense responseGO:00069523150.315
Mouse
zinc ion homeostasisGO:0055069120.315
regulation of response to woundingGO:19030341010.313
Mouse
epithelial cell cell adhesionGO:009013670.313
t cell differentiationGO:0030217290.307
Human Mouse
response to acid chemicalGO:0001101660.306
endodermal cell differentiationGO:0035987310.306
regulation of b cell activationGO:0050864240.306
Mouse
immune responseGO:00069553070.303
Human Mouse Rat
regulation of jak stat cascadeGO:0046425440.300
regulation of lymphocyte mediated immunityGO:0002706330.300
positive regulation of defense responseGO:0031349870.299
negative regulation of mitochondrial depolarizationGO:005190220.296
cellular cation homeostasisGO:00300031630.296
cytosolic calcium ion transportGO:0060401480.295
myeloid cell homeostasisGO:0002262340.292
regulation of receptor mediated endocytosisGO:0048259320.288
positive regulation of mononuclear cell proliferationGO:0032946470.284
Mouse
antigen processing and presentation of peptide antigen via mhc class iGO:000247460.284
negative regulation of platelet activationGO:001054470.283
regulation of map kinase activityGO:00434051080.283
Mouse
caveolin mediated endocytosisGO:007258440.281
negative regulation of sequestering of calcium ionGO:0051283410.281
establishment of spindle orientationGO:005129490.281
negative regulation of intracellular signal transductionGO:19025321830.278
regulation of vesicle mediated transportGO:00606271300.275
Mouse Rat
positive regulation of cysteine type endopeptidase activityGO:2001056790.275
phosphatidylinositol 3 kinase signalingGO:0014065480.274
positive regulation of cytokine biosynthetic processGO:0042108250.269
Mouse
peptidyl threonine phosphorylationGO:0018107410.268
single organism cell adhesionGO:00986021790.261
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002824190.260
cellular response to biotic stimulusGO:0071216710.259
Mouse
mapk cascadeGO:00001652880.258
Mouse Fly
sequestering of calcium ionGO:0051208170.255
defense response to bacteriumGO:0042742630.251
Mouse
cell part morphogenesisGO:00329901370.250
Fly
regulation of inflammatory response to antigenic stimulusGO:000286120.250
regulation of tyrosine phosphorylation of stat5 proteinGO:0042522120.250
regulation of intrinsic apoptotic signaling pathwayGO:2001242720.247
negative regulation of acute inflammatory responseGO:000267430.244
homotypic cell cell adhesionGO:0034109470.244
Mouse
cell morphogenesis involved in differentiationGO:00009041440.243
mitotic cell cycle processGO:19030472860.241
positive regulation of mapk cascadeGO:00434101900.238
Mouse
microtubule based processGO:00070172100.238
regulation of establishment of protein localizationGO:00702012420.238
Mouse
humoral immune response mediated by circulating immunoglobulinGO:000245550.237
response to retinoic acidGO:0032526330.236
system processGO:00030083490.235
negative regulation of kinase activityGO:00336731060.235
gland developmentGO:0048732480.234
regulation of antigen receptor mediated signaling pathwayGO:0050854100.231
negative regulation of map kinase activityGO:0043407270.231
positive regulation of cell developmentGO:0010720920.231
mitotic cell cycleGO:00002783260.230
positive regulation of cell motilityGO:20001471770.228
Zebrafish
negative regulation of humoral immune response mediated by circulating immunoglobulinGO:000292430.227
regulation of organelle assemblyGO:1902115400.224
response to external biotic stimulusGO:00432072610.222
Mouse
calcium ion transportGO:00068161470.222
positive regulation of peptidyl serine phosphorylationGO:0033138420.219
regulation of endocytosisGO:0030100720.213
Mouse
regulation of peptidase activityGO:00525471800.212
post embryonic developmentGO:000979120.211
cellular macromolecular complex assemblyGO:00346223240.210
regulation of secretion by cellGO:19035301770.208
Mouse Rat
divalent metal ion transportGO:00708381520.207
response to estrogenGO:0043627470.206
regulation of kinase activityGO:00435493140.205
Mouse
inflammatory responseGO:0006954790.204
Mouse
regulation of b cell receptor signaling pathwayGO:005085540.200
negative regulation of protein metabolic processGO:00512483910.200
response to molecule of bacterial originGO:0002237820.197
leukocyte homeostasisGO:000177670.196
oocyte differentiationGO:000999420.196
t cell differentiation in thymusGO:003307740.195
Human
cell cell junction organizationGO:0045216690.195
regulation of ion transportGO:00432691890.192
Mouse
activation of cysteine type endopeptidase activityGO:0097202570.189
growthGO:00400072020.186
Fly
positive regulation of response to interferon gammaGO:006033220.183
cytokine secretionGO:0050663640.182
Mouse
negative regulation of protein complex assemblyGO:0031333430.182
regulation of insulin secretionGO:0050796330.181
regulation of nervous system developmentGO:0051960880.181
reactive oxygen species metabolic processGO:0072593750.178
Mouse
negative regulation of immunoglobulin mediated immune responseGO:000289030.178
regulation of protein complex assemblyGO:00432541470.173
glycerophospholipid metabolic processGO:0006650840.172
synapse assemblyGO:000741680.172
actin filament bundle assemblyGO:0051017540.170
protein localization to plasma membraneGO:0072659930.169
peptidyl serine modificationGO:00182091060.168
Mouse
regulation of peptide hormone secretionGO:0090276410.168
regulation of extrinsic apoptotic signaling pathwayGO:2001236850.168
regulation of mapk cascadeGO:00434082620.168
Mouse
regulation of hormone levelsGO:00108171250.167
cellular response to acid chemicalGO:0071229440.166
positive regulation of dna metabolic processGO:0051054730.165
endocytic recyclingGO:0032456120.164
positive regulation of alpha beta t cell activationGO:0046635100.163
Mouse
generation of neuronsGO:00486991520.162
Fly
lymphocyte mediated immunityGO:0002449480.162
zymogen activationGO:0031638700.159
regulation of stress activated protein kinase signaling cascadeGO:0070302850.158
Mouse
positive regulation of proteolysisGO:00458621420.158
defense response to other organismGO:00985421290.157
Mouse
negative regulation of protein processingGO:00109551420.157
determination of adult lifespanGO:000834020.155
cell projection assemblyGO:00300311260.155
regulated secretory pathwayGO:0045055200.155
Mouse Rat
transition metal ion homeostasisGO:0055076310.154
cell adhesionGO:00071553250.153
positive regulation of cell projection organizationGO:0031346640.153
muscle structure developmentGO:0061061980.153
cell morphogenesisGO:00009022960.152
Fly
positive regulation of protein serine threonine kinase activityGO:00719021190.152
Mouse
regulation of response to cytokine stimulusGO:0060759460.152
negative regulation of b cell proliferationGO:003088950.149
negative regulation of smoothened signaling pathwayGO:004587930.148
extrinsic apoptotic signaling pathwayGO:00971911190.148
neutrophil activationGO:004211990.146
Mouse
positive regulation of lymphocyte mediated immunityGO:0002708230.146
negative regulation of immune effector processGO:0002698380.146
leukocyte degranulationGO:0043299110.145
Mouse Rat
positive regulation of myeloid leukocyte cytokine production involved in immune responseGO:006108110.143

SYK disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
immune system diseaseDOID:29141550.994
disease by infectious agentDOID:0050117340.911
hematopoietic system diseaseDOID:741000.816
parasitic infectious diseaseDOID:1398160.689
primary immunodeficiency diseaseDOID:612360.364
b cell deficiencyDOID:2115170.364
blood protein diseaseDOID:620160.360
parasitic protozoa infectious diseaseDOID:2789160.296
malariaDOID:12365160.249