Homo sapiens

0 known processes

SLC24A4

solute carrier family 24 (sodium/potassium/calcium exchanger), member 4

(Aliases: NCKX4,SLC24A2,SHEP6,FLJ38852)

SLC24A4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
post embryonic developmentGO:000979120.066
regulation of cellular ketone metabolic processGO:0010565500.056
cellular amino acid metabolic processGO:00065201160.055
regulation of cellular amino acid metabolic processGO:000652160.055
cellular amine metabolic processGO:0044106410.054
cellular ketone metabolic processGO:0042180800.054
amine metabolic processGO:0009308440.053
regulation of cellular amine metabolic processGO:0033238110.048
positive regulation of hydrolase activityGO:00513453310.045
small gtpase mediated signal transductionGO:0007264780.043
immune responseGO:00069553070.042
organophosphate catabolic processGO:00464344300.040
negative regulation of protein metabolic processGO:00512483910.040
nervous system developmentGO:00073992930.040
purine ribonucleoside metabolic processGO:00461284370.040
ras protein signal transductionGO:0007265730.040
positive regulation of cellular amino acid metabolic processGO:004576430.039
locomotory behaviorGO:000762610.038
multicellular organismal agingGO:001025930.037
negative regulation of cellular protein metabolic processGO:00322693530.036
vesicle mediated transportGO:00161923710.036
determination of adult lifespanGO:000834020.035
regulation of cellular component movementGO:00512703340.035
purine nucleotide catabolic processGO:00061954050.035
regulation of cell differentiationGO:00455953930.035
purine ribonucleotide catabolic processGO:00091544040.035
female gamete generationGO:000729220.035
negative regulation of catalytic activityGO:00430863350.035
system processGO:00030083490.034
Mouse
purine ribonucleoside triphosphate catabolic processGO:00092073910.034
purine ribonucleoside catabolic processGO:00461303980.034
ribonucleoside triphosphate catabolic processGO:00092033910.034
purine nucleoside triphosphate metabolic processGO:00091444120.034
purine containing compound catabolic processGO:00725234110.034
ribonucleotide catabolic processGO:00092614050.034
glycosyl compound catabolic processGO:19016584130.033
ribonucleoside triphosphate metabolic processGO:00091994120.033
cell adhesionGO:00071553250.033
purine nucleoside catabolic processGO:00061523980.033
purine ribonucleoside triphosphate metabolic processGO:00092054110.032
cytokine productionGO:00018162470.032
positive regulation of cellular amine metabolic processGO:003324070.032
oogenesisGO:004847720.032
nucleoside triphosphate metabolic processGO:00091414220.032
ribonucleoside catabolic processGO:00424544060.032
nucleotide catabolic processGO:00091664080.032
lipid metabolic processGO:00066293810.032
purine nucleoside triphosphate catabolic processGO:00091463920.032
regulation of locomotionGO:00400123290.031
negative regulation of cell deathGO:00605483450.031
nucleoside catabolic processGO:00091644080.031
positive regulation of transportGO:00510503360.031
response to oxygen containing compoundGO:19017003690.030
positive regulation of phosphorylationGO:00423273940.030
nucleoside phosphate catabolic processGO:19012924120.030
nucleoside triphosphate catabolic processGO:00091433940.030
biological adhesionGO:00226103310.030
negative regulation of phosphorus metabolic processGO:00105632670.029
positive regulation of immune system processGO:00026842830.029
regulation of cell motilityGO:20001452990.029
response to abiotic stimulusGO:00096283360.029
positive regulation of catabolic processGO:00098963100.029
cytoplasmic transportGO:00164823790.029
cation transmembrane transportGO:00986552380.029
Human Rat
cell developmentGO:00484683280.029
secretionGO:00469032540.029
cell morphogenesisGO:00009022960.029
negative regulation of multicellular organismal processGO:00512413170.029
regulation of protein localizationGO:00328802960.028
single organism cellular localizationGO:19025803320.028
negative regulation of phosphate metabolic processGO:00459362670.028
chemical homeostasisGO:00488783060.028
Rat
regulation of proteolysisGO:00301622930.028
cation transportGO:00068123310.028
Human Rat
regulation of cytokine productionGO:00018172320.028
enzyme linked receptor protein signaling pathwayGO:00071673030.028
defense responseGO:00069523150.027
positive regulation of cellular component organizationGO:00511303760.027
positive regulation of cellular catabolic processGO:00313312840.027
membrane organizationGO:00610242920.027
positive regulation of nucleotide metabolic processGO:00459812300.026
cellular lipid metabolic processGO:00442553030.026
segmentationGO:003528240.026
regulation of nucleotide metabolic processGO:00061402690.026
regulation of secretionGO:00510461940.026
regulation of anatomical structure morphogenesisGO:00226032860.026
innate immune responseGO:00450871780.026
positive regulation of cell deathGO:00109422630.026
regulation of kinase activityGO:00435493140.026
positive regulation of apoptotic processGO:00430652460.025
signal transduction by phosphorylationGO:00230142970.025
cellular component morphogenesisGO:00329893140.024
negative regulation of programmed cell deathGO:00430693210.024
actin filament based processGO:00300292240.024
positive regulation of purine nucleotide metabolic processGO:19005442270.024
secretion by cellGO:00329402260.024
mapk cascadeGO:00001652880.024
regulation of purine nucleotide metabolic processGO:19005422640.024
single organism membrane organizationGO:00448022680.024
negative regulation of apoptotic processGO:00430663160.024
protein processingGO:00164852260.024
regulation of cell cycleGO:00517263930.024
metal ion transportGO:00300012720.024
Human Rat
cellular macromolecule catabolic processGO:00442653800.024
neuromuscular junction developmentGO:000752830.023
regulation of response to external stimulusGO:00321012220.023
regulation of immune responseGO:00507762010.023
cell projection organizationGO:00300302520.023
mitotic cell cycleGO:00002783260.023
regulation of protein kinase activityGO:00458592890.023
cellular response to dna damage stimulusGO:00069743790.023
ion transmembrane transportGO:00342203380.023
Human Rat
regulation of transferase activityGO:00513383550.023
protein maturationGO:00516042330.023
regulation of cell migrationGO:00303342890.023
negative regulation of cellular component organizationGO:00511292350.023
negative regulation of cell proliferationGO:00082852280.023
regulation of mapk cascadeGO:00434082620.022
guanosine containing compound catabolic processGO:19010692390.022
regulation of protein transportGO:00512232130.022
memoryGO:000761330.022
positive regulation of programmed cell deathGO:00430682490.022
regulation of sequence specific dna binding transcription factor activityGO:00510902110.022
cellular response to oxygen containing compoundGO:19017012760.022
regulation of nucleoside metabolic processGO:00091182090.022
cell activationGO:00017752130.022
peripheral nervous system developmentGO:000742220.022
regulation of establishment of protein localizationGO:00702012420.022
transmembrane transportGO:00550853990.022
Human Rat
positive regulation of purine nucleotide catabolic processGO:00331231850.022
positive regulation of cell proliferationGO:00082843010.022
nitrogen compound transportGO:00717051910.022
positive regulation of cell differentiationGO:00455972110.021
response to other organismGO:00517072610.021
response to external biotic stimulusGO:00432072610.021
positive regulation of transferase activityGO:00513472270.021
protein catabolic processGO:00301633250.021
gtp metabolic processGO:00460392390.021
hindbrain developmentGO:003090230.021
cellular response to endogenous stimulusGO:00714953360.021
gtp catabolic processGO:00061842370.021
regenerationGO:003109940.021
rho protein signal transductionGO:0007266260.021
negative regulation of protein modification processGO:00314002000.021
positive regulation of developmental processGO:00510943140.021
positive regulation of nucleoside metabolic processGO:00459791860.021
anatomical structure formation involved in morphogenesisGO:00486462840.021
regulation of cellular response to stressGO:00801352440.021
negative regulation of hydrolase activityGO:00513461820.020
immune system developmentGO:00025201950.020
dephosphorylationGO:00163112090.020
ion homeostasisGO:00508012300.020
Rat
hematopoietic or lymphoid organ developmentGO:00485341860.020
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.020
regulation of secretion by cellGO:19035301770.020
guanosine containing compound metabolic processGO:19010682440.020
hemopoiesisGO:00300971800.020
regulation of purine nucleotide catabolic processGO:00331212050.020
cellular macromolecular complex assemblyGO:00346223240.020
rhythmic behaviorGO:000762220.020
regulation of peptidase activityGO:00525471800.020
negative regulation of transportGO:00510511760.020
regulation of nucleotide catabolic processGO:00308112050.020
regulation of cellular component biogenesisGO:00440872810.020
negative regulation of intracellular signal transductionGO:19025321830.019
positive regulation of protein phosphorylationGO:00019343130.019
regulation of endopeptidase activityGO:00525481700.019
protein localization to organelleGO:00333652800.019
carbohydrate metabolic processGO:00059752070.019
neurological system processGO:00508771630.019
Mouse
apoptotic signaling pathwayGO:00971902680.019
anterior posterior axis specificationGO:000994820.019
oocyte differentiationGO:000999420.019
adult locomotory behaviorGO:000834410.019
negative regulation of cellular amino acid metabolic processGO:004576320.019
immune effector processGO:00022521590.019
negative regulation of developmental processGO:00510932470.019
negative regulation of phosphorylationGO:00423261740.019
carbohydrate derivative biosynthetic processGO:19011372070.019
leukocyte activationGO:00453211640.019
mitotic cell cycle processGO:19030472860.018
positive regulation of nucleotide catabolic processGO:00308131850.018
oocyte developmentGO:004859910.018
anion transportGO:00068201610.018
inorganic cation transmembrane transportGO:00986621940.018
Human Rat
negative regulation of cellular amine metabolic processGO:003323930.018
positive regulation of gtpase activityGO:00435471660.018
blastoderm segmentationGO:000735020.018
maintenance of locationGO:00512351120.018
positive regulation of immune responseGO:00507781590.018
intracellular protein transportGO:00068862700.018
cellular protein catabolic processGO:00442572610.018
chromatin organizationGO:00063253510.018
regulation of gtpase activityGO:00430871800.018
regulation of cell cycle processGO:00105642660.018
response to biotic stimulusGO:00096072760.018
oxidation reduction processGO:00551143960.018
regulation of cell developmentGO:00602841610.018
positive regulation of gtp catabolic processGO:00331261660.018
response to nitrogen compoundGO:19016981840.018
protein ubiquitinationGO:00165673140.018
cation homeostasisGO:00550801890.018
Rat
protein modification by small protein conjugationGO:00324463420.017
negative regulation of protein phosphorylationGO:00019331400.017
microtubule based processGO:00070172100.017
chromatin modificationGO:00165682980.017
spermatid differentiationGO:004851540.017
cell fate determinationGO:000170930.017
metencephalon developmentGO:002203720.017
cardiovascular system developmentGO:00723582620.017
regulation of intracellular transportGO:00323861950.017
positive regulation of cytokine productionGO:00018191670.017
lipid biosynthetic processGO:00086101770.017
positive regulation of kinase activityGO:00336742040.017
organonitrogen compound biosynthetic processGO:19015662000.017
regulation of synaptic plasticityGO:004816730.017
circulatory system developmentGO:00723592620.017
proteolysis involved in cellular protein catabolic processGO:00516032440.017
single organism carbohydrate metabolic processGO:00447231930.017
cardiac muscle cell contractionGO:008600340.017
single organism cell adhesionGO:00986021790.017
response to woundingGO:00096111680.017
regulation of ras protein signal transductionGO:00465781550.017
associative learningGO:000830610.017
morphogenesis of embryonic epitheliumGO:001633140.017
endocytosisGO:00068971590.017
positive regulation of cell motilityGO:20001471770.017
positive regulation of protein kinase activityGO:00458601900.017
histone modificationGO:00165702510.016
lymphocyte activationGO:00466491330.016
regulation of gtp catabolic processGO:00331241800.016
nerve developmentGO:002167540.016
cellular homeostasisGO:00197251960.016
Rat
organic anion transportGO:00157111030.016
neurogenesisGO:00220081690.016
positive regulation of organelle organizationGO:00106381950.016
positive regulation of proteolysisGO:00458621420.016
regulation of small gtpase mediated signal transductionGO:00510561560.016
positive regulation of synaptic transmissionGO:005080640.016
covalent chromatin modificationGO:00165692540.016
regulation of neural precursor cell proliferationGO:200017740.016
central nervous system developmentGO:00074171230.016
regulation of defense responseGO:00313471540.016
head developmentGO:00603221080.016
protein localization to membraneGO:00726571600.016
neuron differentiationGO:00301821380.016
circadian behaviorGO:004851220.016
negative regulation of immune system processGO:00026831360.015
positive regulation of mapk cascadeGO:00434101900.015
epithelium developmentGO:00604292270.015
regulation of leukocyte activationGO:00026941150.015
regulation of ion transportGO:00432691890.015
regulation of protein serine threonine kinase activityGO:00719001790.015
response to lipidGO:00339932060.015
small molecule biosynthetic processGO:00442831570.015
compound eye developmentGO:004874910.015
regulation of vesicle mediated transportGO:00606271300.015
cellular chemical homeostasisGO:00550821800.015
Rat
inorganic ion transmembrane transportGO:00986602310.015
Human Rat
regulation of cell activationGO:00508651250.015
immune response regulating signaling pathwayGO:0002764970.015
neuroblast proliferationGO:000740540.015
spermatid developmentGO:000728640.015
photoreceptor cell differentiationGO:004653020.015
regulation of protein maturationGO:19033171500.015
monocarboxylic acid metabolic processGO:00327871850.015
regulation of cell morphogenesisGO:00226041530.015
regulation of protein processingGO:00706131500.015
endomembrane system organizationGO:00102561960.015
cerebellum developmentGO:002154920.015
detection of stimulusGO:0051606850.015
single organismal cell cell adhesionGO:00163371480.015
negative regulation of cell cycleGO:00457861930.015
positive regulation of ras gtpase activityGO:00323201170.015
positive regulation of protein transportGO:00512221350.015
response to fungusGO:000962040.014
negative regulation of protein processingGO:00109551420.014
anterior posterior axis specification embryoGO:000859520.014
cellular response to cytokine stimulusGO:00713451810.014
response to cytokineGO:00340972320.014
tripartite regional subdivisionGO:000735120.014
generation of neuronsGO:00486991520.014
immune response activating signal transductionGO:0002757900.014
negative regulation of protein maturationGO:19033181420.014
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.014
growthGO:00400072020.014
regulation of mitotic cell cycleGO:00073461890.014
cell growthGO:00160491600.014
organ formationGO:004864530.014
brain developmentGO:0007420970.014
protein targetingGO:00066051870.014
cranial nerve developmentGO:002154540.014
embryonic camera type eye developmentGO:003107620.014
regulation of multi organism processGO:00439001570.014
regulation of apoptotic signaling pathwayGO:20012331750.014
organophosphate biosynthetic processGO:00904071630.014
regulation of ras gtpase activityGO:00323181280.014
positive regulation of cellular component biogenesisGO:00440891580.014
activation of immune responseGO:00022531140.014
regulation of cell adhesionGO:00301551660.014
posttranscriptional regulation of gene expressionGO:00106082130.014
regulation of i kappab kinase nf kappab signalingGO:00431221620.014
vasculature developmentGO:00019441810.014
response to organic cyclic compoundGO:00140702040.014
metal ion homeostasisGO:00550651690.014
Rat
release of cytoplasmic sequestered nf kappabGO:000858840.014
positive regulation of secretion by cellGO:19035321080.014
actin cytoskeleton organizationGO:00300362070.014
embryonic epithelial tube formationGO:000183840.014
regulation of cytoskeleton organizationGO:00514931770.014
cellular protein complex assemblyGO:00436231880.014
angiogenesisGO:00015251470.014
t cell activationGO:0042110990.014
positive regulation of cellular component movementGO:00512721810.013
cell part morphogenesisGO:00329901370.013
neurotransmitter secretionGO:000726940.013
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.013
actin mediated cell contractionGO:0070252120.013
regulation of lymphocyte activationGO:00512491030.013
protein oligomerizationGO:00512591730.013
regulation of growthGO:00400081650.013
protein secretionGO:0009306980.013
cell divisionGO:00513011680.013
taxisGO:00423301570.013
matingGO:000761810.013
glycoprotein metabolic processGO:00091001100.013
monovalent inorganic cation transportGO:00156721280.013
Human Rat
proteasomal protein catabolic processGO:00104981760.013
rna interferenceGO:001624640.013
microtubule cytoskeleton organizationGO:00002261760.013
peptidyl tyrosine modificationGO:00182121700.013
positive regulation of locomotionGO:00400171860.013
atp metabolic processGO:00460341760.013
actin filament based movementGO:0030048170.013
regulation of response to woundingGO:19030341010.013
modification dependent macromolecule catabolic processGO:00436322120.013
peptidyl tyrosine phosphorylationGO:00181081700.013
protein autophosphorylationGO:00467771230.013
negative regulation of locomotionGO:00400131180.013
purine nucleoside monophosphate metabolic processGO:00091261860.013
purine ribonucleoside monophosphate metabolic processGO:00091671860.013
reactive oxygen species biosynthetic processGO:190340940.013
response to axon injuryGO:004867810.013
organelle assemblyGO:00709251760.013
regulation of membrane potentialGO:0042391950.013
regulation of cytoplasmic transportGO:19036491490.013
cell projection morphogenesisGO:00488581290.013
reactive oxygen species metabolic processGO:0072593750.013
regulation of hormone levelsGO:00108171250.013
negative regulation of cellular component movementGO:00512711060.013
regulation of dna metabolic processGO:00510521530.013
nucleoside monophosphate metabolic processGO:00091231910.013
regulation of cysteine type endopeptidase activityGO:20001161270.013
modification dependent protein catabolic processGO:00199412090.013
negative regulation of cell differentiationGO:00455961710.013
blood vessel developmentGO:00015681720.013
reactive nitrogen species metabolic processGO:200105730.013
negative regulation of proteolysisGO:00458611320.013
regulation of protein catabolic processGO:00421761550.012
limbic system developmentGO:002176130.012
ribonucleoside monophosphate metabolic processGO:00091611870.012
cellular cation homeostasisGO:00300031630.012
Rat
dna repairGO:00062811980.012
cell cycle phase transitionGO:00447701730.012
cellular metal ion homeostasisGO:00068751460.012
Rat
neuron developmentGO:00486661130.012
negative regulation of transferase activityGO:00513481240.012
negative regulation of cell migrationGO:00303361020.012
myeloid cell differentiationGO:00300991170.012
cellular ion homeostasisGO:00068731680.012
Rat
motor neuron axon guidanceGO:000804520.012
chemotaxisGO:00069351570.012
nuclear transportGO:00511691790.012
rna processingGO:00063962550.012
regulation of meiotic cell cycleGO:005144540.012
organic hydroxy compound metabolic processGO:19016151470.012
epithelium migrationGO:00901321190.012
response to virusGO:00096151260.012
regulation of complement activation alternative pathwayGO:003045110.012
regulation of reactive oxygen species biosynthetic processGO:190342630.012
nucleocytoplasmic transportGO:00069131760.012
i kappab kinase nf kappab signalingGO:00072491660.012
calcium ion homeostasisGO:00550741220.012
Rat
response to bacteriumGO:00096171440.012
syncytium formation by plasma membrane fusionGO:000076820.012
blood vessel morphogenesisGO:00485141620.012
negative regulation of organelle organizationGO:00106391260.012
long term memoryGO:000761620.012
regulation of homeostatic processGO:00328441210.012
nucleoside phosphate biosynthetic processGO:19012931090.012
positive regulation of secretionGO:00510471160.012
negative regulation of alpha beta t cell activationGO:004663630.012
cardiac muscle contractionGO:0060048340.012
leukocyte migrationGO:00509001070.012
cellular response to lipidGO:00713961270.012
visual behaviorGO:000763220.012
wnt signaling pathwayGO:00160551560.012
intrinsic apoptotic signaling pathwayGO:00971931270.012
cell projection assemblyGO:00300311260.012
alcohol metabolic processGO:00060661140.012
somitogenesisGO:000175620.012
regulation of cell growthGO:00015581350.012
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.012
sex determinationGO:000753030.012
divalent inorganic cation transportGO:00725111580.012
Human Rat
ameboidal type cell migrationGO:00016671350.011
cell morphogenesis involved in differentiationGO:00009041440.011
mitochondrion organizationGO:00070051560.011
response to radiationGO:00093141510.011
morphogenesis of a polarized epitheliumGO:000173830.011
cellular response to growth factor stimulusGO:00713631970.011
positive regulation of peptidase activityGO:0010952880.011
sulfur compound metabolic processGO:00067901010.011
stem cell divisionGO:001714520.011
ubiquitin dependent protein catabolic processGO:00065112060.011
defense response to other organismGO:00985421290.011
cell cell signalingGO:00072671550.011
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.011
cell substrate adhesionGO:00315891320.011
regulation of dephosphorylationGO:0035303960.011
organ morphogenesisGO:00098871470.011
Mouse
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.011
regulation of innate immune responseGO:0045088970.011
thymus developmentGO:004853830.011
sensory perceptionGO:00076001030.011
Mouse
sequestering of metal ionGO:0051238240.011
endosomal transportGO:00161971290.011
ossificationGO:00015031210.011
tube closureGO:006060630.011
establishment of protein localization to organelleGO:00725941720.011
divalent metal ion transportGO:00708381520.011
Human Rat
negative regulation of secretion by cellGO:1903531520.011
blastocyst developmentGO:000182430.011
neural tube formationGO:000184130.011
mitotic cell cycle phase transitionGO:00447721620.011
positive regulation of endopeptidase activityGO:0010950840.011
negative regulation of synaptic transmissionGO:005080520.011
tissue regenerationGO:004224630.011
establishment of protein localization to membraneGO:00901501210.011
positive regulation of reactive oxygen species biosynthetic processGO:190342820.011
defense response to fungusGO:005083240.011
cytokine secretionGO:0050663640.011
response to growth factorGO:00708482050.011
neuron projection developmentGO:00311751060.011
epithelial cell differentiationGO:00308551410.011
sleepGO:003043120.011
cellular response to abiotic stimulusGO:00712141170.011
fatty acid metabolic processGO:00066311150.011
protein acylationGO:00435431380.011
salivary gland morphogenesisGO:000743540.011
negative regulation of phagocytosisGO:005076540.011
regulation of protein secretionGO:0050708860.011
visual learningGO:000854210.011
glycerolipid metabolic processGO:00464861070.011
response to organonitrogen compoundGO:00102431560.011
symbiosis encompassing mutualism through parasitismGO:00444031560.011
sequestering of calcium ionGO:0051208170.011
inner ear morphogenesisGO:004247240.011
protein homooligomerizationGO:00512601000.011
primary neural tube formationGO:001402030.010
regulation of lipid metabolic processGO:0019216960.010
positive regulation of cell migrationGO:00303351720.010
neuron fate commitmentGO:004866320.010
positive regulation of neural precursor cell proliferationGO:200017920.010
neural tube closureGO:000184330.010
cellular response to nitrogen compoundGO:19016991440.010
negative regulation of growthGO:0045926970.010
regulation of protein complex assemblyGO:00432541470.010
tissue migrationGO:00901301190.010
negative regulation of peptidase activityGO:0010466910.010
specification of organ identityGO:001009230.010
negative regulation of cell motilityGO:20001461040.010
t cell differentiation in thymusGO:003307740.010
regulation of immune effector processGO:0002697910.010
positive regulation of cell developmentGO:0010720920.010
forebrain generation of neuronsGO:002187230.010

SLC24A4 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
sensory system diseaseDOID:00501552030.032
nervous system diseaseDOID:8634310.032
musculoskeletal system diseaseDOID:172230.026
disease of metabolismDOID:00146672950.024
eye and adnexa diseaseDOID:14921500.024
eye diseaseDOID:56141490.024
inherited metabolic disorderDOID:6552420.018
retinal diseaseDOID:56791180.018
central nervous system diseaseDOID:3311860.017
disease of cellular proliferationDOID:145661740.016
cancerDOID:1621670.015
organ system cancerDOID:00506861640.015
connective tissue diseaseDOID:651090.015
bone diseaseDOID:0080001880.014
retinal degenerationDOID:8466890.012
immune system diseaseDOID:29141550.012
neurodegenerative diseaseDOID:12891020.011