Homo sapiens

30 known processes

CYP17A1

cytochrome P450, family 17, subfamily A, polypeptide 1

(Aliases: CYP17,P450C17,CPT7,S17AH)

CYP17A1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cation transportGO:00068123310.342
system processGO:00030083490.307
regulation of hormone levelsGO:00108171250.220
g protein coupled receptor signaling pathwayGO:00071862070.208
transmembrane transportGO:00550853990.197
response to oxygen containing compoundGO:19017003690.170
Rat
chemical homeostasisGO:00488783060.169
blood circulationGO:00080151130.135
ion transmembrane transportGO:00342203380.129
inorganic ion transmembrane transportGO:00986602310.125
ion homeostasisGO:00508012300.123
urate transportGO:001574730.122
cation transmembrane transportGO:00986552380.114
anion transportGO:00068201610.112
metal ion transportGO:00300012720.101
nitrogen compound transportGO:00717051910.097
response to abiotic stimulusGO:00096283360.096
Rat
glycine importGO:003623310.091
cellular metal ion homeostasisGO:00068751460.079
cellular ion homeostasisGO:00068731680.077
response to organonitrogen compoundGO:00102431560.076
Rat
cell cell signalingGO:00072671550.075
inorganic cation transmembrane transportGO:00986621940.074
muscle contractionGO:0006936730.072
positive regulation of transportGO:00510503360.070
regulation of system processGO:00440571010.067
cellular amino acid metabolic processGO:00065201160.066
epithelial cell differentiationGO:00308551410.066
post embryonic developmentGO:000979120.066
cellular homeostasisGO:00197251960.065
response to nitrogen compoundGO:19016981840.063
Rat
cellular chemical homeostasisGO:00550821800.063
divalent inorganic cation homeostasisGO:00725071360.056
positive regulation of cellular component organizationGO:00511303760.054
cation homeostasisGO:00550801890.054
regulation of cellular ketone metabolic processGO:0010565500.054
regulation of transmission of nerve impulseGO:005196920.053
calcium ion homeostasisGO:00550741220.051
cellular cation homeostasisGO:00300031630.051
response to lipidGO:00339932060.049
Rat
regulation of cell cycleGO:00517263930.049
endocrine processGO:0050886250.049
response to organic cyclic compoundGO:00140702040.048
Human Rat
cytoplasmic transportGO:00164823790.048
carboxylic acid transportGO:0046942630.047
cellular response to oxygen containing compoundGO:19017012760.046
Rat
nervous system developmentGO:00073992930.045
Rat
regulation of ion transportGO:00432691890.044
regulation of proteolysisGO:00301622930.044
epithelium developmentGO:00604292270.044
anion transmembrane transportGO:0098656760.043
cellular amine metabolic processGO:0044106410.043
positive regulation of developmental processGO:00510943140.042
l amino acid importGO:004309240.042
synaptic transmission glycinergicGO:006001210.042
organonitrogen compound biosynthetic processGO:19015662000.042
locomotory behaviorGO:000762610.041
regulation of cellular amino acid metabolic processGO:000652160.040
hormone transportGO:0009914680.040
metal ion homeostasisGO:00550651690.040
muscle system processGO:0003012810.039
hindbrain developmentGO:003090230.039
sodium ion transmembrane transportGO:0035725590.038
purine ribonucleoside metabolic processGO:00461284370.038
lipid biosynthetic processGO:00086101770.037
Mouse Rat
regulation of cellular amine metabolic processGO:0033238110.037
cellular response to endogenous stimulusGO:00714953360.037
Rat
actin filament based movementGO:0030048170.037
cellular ketone metabolic processGO:0042180800.037
protein localization to organelleGO:00333652800.037
regulation of transferase activityGO:00513383550.037
amine metabolic processGO:0009308440.037
response to hormoneGO:00097251750.037
Rat
divalent inorganic cation transportGO:00725111580.037
membrane organizationGO:00610242920.036
hormone secretionGO:0046879650.036
cardiac muscle cell contractionGO:008600340.036
circulatory system processGO:00030131130.036
actin filament based processGO:00300292240.036
vesicle mediated transportGO:00161923710.036
immune responseGO:00069553070.036
single organism carbohydrate metabolic processGO:00447231930.035
regulation of response to external stimulusGO:00321012220.035
multicellular organismal agingGO:001025930.035
negative regulation of catalytic activityGO:00430863350.035
secretionGO:00469032540.035
mitotic cell cycleGO:00002783260.035
organic acid transportGO:0015849650.035
organophosphate biosynthetic processGO:00904071630.035
cytosolic calcium ion homeostasisGO:0051480890.034
negative regulation of cell deathGO:00605483450.034
determination of adult lifespanGO:000834020.034
positive regulation of cell proliferationGO:00082843010.034
lipid metabolic processGO:00066293810.034
cell developmentGO:00484683280.033
cellular divalent inorganic cation homeostasisGO:00725031280.033
positive regulation of cellular amine metabolic processGO:003324070.033
negative regulation of cellular protein metabolic processGO:00322693530.033
single organism cellular localizationGO:19025803320.033
protein maturationGO:00516042330.032
actin mediated cell contractionGO:0070252120.032
alcohol metabolic processGO:00060661140.032
Human
cellular response to nitrogen compoundGO:19016991440.032
regulation of acrosome reactionGO:006004640.032
anatomical structure homeostasisGO:00602491000.032
negative regulation of apoptotic processGO:00430663160.032
ribonucleoside catabolic processGO:00424544060.032
wnt signaling pathwayGO:00160551560.032
cellular response to histamineGO:007142030.032
regulation of growthGO:00400081650.031
nucleoside phosphate biosynthetic processGO:19012931090.031
nucleotide biosynthetic processGO:00091651090.031
organic anion transportGO:00157111030.031
calcium ion transportGO:00068161470.031
regulation of purine nucleotide metabolic processGO:19005422640.031
regulation of metal ion transportGO:00109591200.031
protein processingGO:00164852260.030
positive regulation of purine nucleotide metabolic processGO:19005442270.030
cellular calcium ion homeostasisGO:00068741170.030
glycine transportGO:001581630.030
positive regulation of nucleotide metabolic processGO:00459812300.030
organic hydroxy compound transportGO:0015850630.030
divalent metal ion transportGO:00708381520.030
metencephalon developmentGO:002203720.030
positive regulation of acrosome reactionGO:200034440.030
serotonin uptakeGO:005161020.030
regulation of membrane potentialGO:0042391950.030
negative regulation of protein metabolic processGO:00512483910.030
negative regulation of cell proliferationGO:00082852280.029
response to other organismGO:00517072610.029
Rat
ribonucleotide catabolic processGO:00092614050.029
cell adhesionGO:00071553250.028
organophosphate catabolic processGO:00464344300.028
negative regulation of transmission of nerve impulseGO:005197010.028
peripheral nervous system developmentGO:000742220.028
monovalent inorganic cation transportGO:00156721280.028
regulation of locomotionGO:00400123290.028
cellular response to organonitrogen compoundGO:00714171240.028
female gamete generationGO:000729220.028
Rat
secretion by cellGO:00329402260.028
sodium independent organic anion transportGO:004325220.028
positive regulation of phosphorylationGO:00423273940.028
alpha ketoglutarate transportGO:001574210.028
mapk cascadeGO:00001652880.028
regulation of body fluid levelsGO:0050878990.027
response to radiationGO:00093141510.027
Rat
carbohydrate derivative biosynthetic processGO:19011372070.027
regulation of nucleotide metabolic processGO:00061402690.027
sodium ion transportGO:0006814610.027
purine ribonucleoside triphosphate catabolic processGO:00092073910.027
cardiac muscle contractionGO:0060048340.027
regenerationGO:003109940.027
regulation of cell motilityGO:20001452990.026
camp metabolic processGO:0046058610.026
organic hydroxy compound metabolic processGO:19016151470.026
Human Rat
neurological system processGO:00508771630.026
purine ribonucleotide catabolic processGO:00091544040.026
nucleoside catabolic processGO:00091644080.026
purine nucleoside triphosphate metabolic processGO:00091444120.026
purine containing compound catabolic processGO:00725234110.026
intracellular protein transportGO:00068862700.026
cell growthGO:00160491600.026
positive regulation of transferase activityGO:00513472270.026
negative regulation of multicellular organismal processGO:00512413170.026
single organism membrane organizationGO:00448022680.025
negative regulation of phosphorus metabolic processGO:00105632670.025
carnitine transmembrane transportGO:190260330.025
nucleoside triphosphate catabolic processGO:00091433940.025
response to external biotic stimulusGO:00432072610.024
Rat
positive regulation of cellular amino acid metabolic processGO:004576430.024
regulation of heart contractionGO:0008016500.024
regulation of cellular component movementGO:00512703340.024
positive regulation of cell motilityGO:20001471770.024
regulation of cell migrationGO:00303342890.024
regulation of secretionGO:00510461940.024
short chain fatty acid importGO:001591310.024
nucleotide catabolic processGO:00091664080.024
negative regulation of wnt signaling pathwayGO:0030178690.024
ribonucleoside triphosphate metabolic processGO:00091994120.024
negative regulation of phosphate metabolic processGO:00459362670.024
rhythmic behaviorGO:000762220.024
action potentialGO:0001508340.024
sensory perceptionGO:00076001030.024
ribonucleoside triphosphate catabolic processGO:00092033910.024
positive regulation of catabolic processGO:00098963100.023
regulation of wnt signaling pathwayGO:00301111230.023
positive regulation of synaptic transmissionGO:005080640.023
oxidation reduction processGO:00551143960.023
growthGO:00400072020.023
gland developmentGO:0048732480.023
Rat
nucleoside triphosphate metabolic processGO:00091414220.023
purine ribonucleoside monophosphate metabolic processGO:00091671860.023
positive regulation of protein phosphorylationGO:00019343130.023
startle responseGO:000196430.023
cellular response to dna damage stimulusGO:00069743790.023
biological adhesionGO:00226103310.023
regulation of cell differentiationGO:00455953930.023
regulation of cell cycle processGO:00105642660.023
reactive oxygen species metabolic processGO:0072593750.022
nucleoside phosphate catabolic processGO:19012924120.022
positive regulation of hydrolase activityGO:00513453310.022
central nervous system developmentGO:00074171230.022
Rat
potassium ion transportGO:0006813620.022
cyclic nucleotide metabolic processGO:0009187820.022
negative regulation of programmed cell deathGO:00430693210.022
defense responseGO:00069523150.022
regulation of peptidase activityGO:00525471800.022
glycosyl compound catabolic processGO:19016584130.022
striated muscle contractionGO:0006941520.022
regulation of cell growthGO:00015581350.021
regulation of secretion by cellGO:19035301770.021
circadian behaviorGO:004851220.021
atp catabolic processGO:00062001570.021
cerebellum developmentGO:002154920.021
nucleoside monophosphate catabolic processGO:00091251590.021
positive regulation of digestive system processGO:006045620.021
behaviorGO:00076101120.021
tissue homeostasisGO:0001894630.021
negative regulation of voltage gated calcium channel activityGO:190138640.021
carbohydrate metabolic processGO:00059752070.021
cellular modified amino acid metabolic processGO:0006575640.021
reactive oxygen species biosynthetic processGO:190340940.021
oogenesisGO:004847720.021
purine ribonucleoside catabolic processGO:00461303980.021
purine nucleotide catabolic processGO:00061954050.021
multicellular organismal response to stressGO:003355510.021
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messengerGO:0007187430.021
ribonucleoside monophosphate metabolic processGO:00091611870.021
organ morphogenesisGO:00098871470.021
endocrine system developmentGO:0035270260.021
Rat
memoryGO:000761330.021
regulation of cellular component biogenesisGO:00440872810.021
ribonucleotide biosynthetic processGO:0009260810.021
purine nucleoside catabolic processGO:00061523980.021
purine ribonucleoside triphosphate metabolic processGO:00092054110.021
protein catabolic processGO:00301633250.021
innate immune responseGO:00450871780.021
purine ribonucleotide biosynthetic processGO:0009152790.021
negative regulation of transportGO:00510511760.021
regulation of kinase activityGO:00435493140.020
positive regulation of cellular catabolic processGO:00313312840.020
negative regulation of phosphorylationGO:00423261740.020
regulation of cyclic nucleotide metabolic processGO:0030799630.020
cellular response to organic cyclic compoundGO:00714071270.020
Human
inorganic anion transmembrane transportGO:0098661470.020
maintenance of locationGO:00512351120.020
hormone metabolic processGO:0042445610.020
response to steroid hormoneGO:0048545800.020
Rat
signal releaseGO:0023061700.020
response to drugGO:0042493810.020
Human Rat
neuromuscular junction developmentGO:000752830.020
regulation of protein kinase activityGO:00458592890.020
generation of neuronsGO:00486991520.020
circulatory system developmentGO:00723592620.020
regulation of transmembrane transportGO:00347621390.020
response to light stimulusGO:0009416870.020
cardiovascular system developmentGO:00723582620.020
purine nucleoside triphosphate catabolic processGO:00091463920.020
purine ribonucleoside monophosphate catabolic processGO:00091691580.020
brain developmentGO:0007420970.020
Rat
small molecule biosynthetic processGO:00442831570.020
anatomical structure formation involved in morphogenesisGO:00486462840.019
regulation of adenylate cyclase activityGO:0045761170.019
ribose phosphate biosynthetic processGO:0046390820.019
positive regulation of ion transportGO:0043270870.019
sensory perception of painGO:001923340.019
salivary gland morphogenesisGO:000743540.019
synaptic transmissionGO:0007268610.019
regulation of protein localizationGO:00328802960.019
regulation of reactive oxygen species metabolic processGO:2000377410.019
segmentationGO:003528240.019
phospholipase c activating g protein coupled receptor signaling pathwayGO:0007200150.019
positive regulation of cellular component biogenesisGO:00440891580.019
cellular response to disaccharide stimulusGO:007132410.019
reactive nitrogen species metabolic processGO:200105730.019
positive regulation of cellular component movementGO:00512721810.019
positive regulation of locomotionGO:00400171860.019
endomembrane system organizationGO:00102561960.019
cellular response to ammonium ionGO:007124240.019
cyclic nucleotide biosynthetic processGO:0009190610.019
positive regulation of cell differentiationGO:00455972110.019
signal transduction by phosphorylationGO:00230142970.019
regulation of hormone secretionGO:0046883570.019
positive regulation of immune system processGO:00026842830.018
regulation of mapk cascadeGO:00434082620.018
regulation of ion transmembrane transportGO:00347651320.018
nicotinate transportGO:200114210.018
cell projection organizationGO:00300302520.018
purine nucleoside monophosphate metabolic processGO:00091261860.018
purine nucleoside monophosphate catabolic processGO:00091281580.018
motor neuron axon guidanceGO:000804520.018
sensory perception of light stimulusGO:0050953350.018
nucleoside monophosphate metabolic processGO:00091231910.018
cellular macromolecule catabolic processGO:00442653800.018
atp metabolic processGO:00460341760.018
response to disaccharideGO:003428510.018
mitochondrion organizationGO:00070051560.018
negative regulation of hydrolase activityGO:00513461820.018
regulation of purine nucleotide biosynthetic processGO:1900371500.018
regulation of reactive oxygen species biosynthetic processGO:190342630.018
purine containing compound biosynthetic processGO:0072522880.018
purine nucleotide biosynthetic processGO:0006164840.018
response to fungusGO:000962040.018
epidermis morphogenesisGO:004873030.018
positive regulation of organelle organizationGO:00106381950.017
organ formationGO:004864530.017
nerve developmentGO:002167540.017
response to biotic stimulusGO:00096072760.017
Rat
response to peptideGO:1901652650.017
cellular response to abiotic stimulusGO:00712141170.017
cellular response to external stimulusGO:00714961110.017
negative regulation of cellular amino acid metabolic processGO:004576320.017
negative regulation of cell differentiationGO:00455961710.017
spinal cord developmentGO:002151040.017
sialic acid transportGO:001573910.017
response to inorganic substanceGO:00100351270.017
positive regulation of intestinal epithelial structure maintenanceGO:006073110.017
matingGO:000761810.017
regulation of calcium ion transportGO:0051924790.017
regulation of homeostatic processGO:00328441210.017
heart contractionGO:0060047620.017
drinking behaviorGO:004275610.017
somatic stem cell maintenanceGO:003501940.017
small gtpase mediated signal transductionGO:0007264780.017
regulation of cytokine productionGO:00018172320.017
regulation of protein maturationGO:19033171500.017
dephosphorylationGO:00163112090.017
protein targetingGO:00066051870.017
regulation of cyclic nucleotide biosynthetic processGO:0030802490.016
single organism reproductive processGO:0044702980.016
Rat
positive regulation of cell cycleGO:00457871400.016
inner ear morphogenesisGO:004247240.016
amino acid importGO:004309040.016
calcium ion transmembrane transportGO:0070588760.016
regulation of protein processingGO:00706131500.016
positive regulation of cell deathGO:00109422630.016
head developmentGO:00603221080.016
Rat
cellular response to hormone stimulusGO:00328701250.016
Rat
retina homeostasisGO:0001895420.016
reproductive processGO:00224141060.016
Rat
vasodilationGO:004231140.016
cyclic purine nucleotide metabolic processGO:0052652600.016
negative regulation of protein maturationGO:19033181420.016
muscle structure developmentGO:0061061980.016
regulation of immune responseGO:00507762010.016
sex determinationGO:000753030.016
cellular potassium ion transportGO:0071804600.016
proline transportGO:001582440.016
regulation of synaptic plasticityGO:004816730.016
regulation of lyase activityGO:0051339230.016
apoptotic signaling pathwayGO:00971902680.016
positive regulation of kinase activityGO:00336742040.016
regulation of vesicle mediated transportGO:00606271300.016
regulation of anatomical structure morphogenesisGO:00226032860.016
multicellular organismal homeostasisGO:0048871670.016
serotonin transportGO:000683730.016
regulation of epithelial cell proliferationGO:00506781130.016
negative regulation of cellular amine metabolic processGO:003323930.016
potassium ion transmembrane transportGO:0071805600.015
tissue migrationGO:00901301190.015
adenylate cyclase modulating g protein coupled receptor signaling pathwayGO:0007188430.015
negative regulation of cellular component organizationGO:00511292350.015
regulation of cellular response to stressGO:00801352440.015
homeostasis of number of cells in a free living populationGO:004887410.015
negative regulation of intracellular signal transductionGO:19025321830.015
positive regulation of cytosolic calcium ion concentrationGO:0007204820.015
organic hydroxy compound biosynthetic processGO:1901617710.015
protein modification by small protein conjugationGO:00324463420.015
cell fate determinationGO:000170930.015
regulation of defense responseGO:00313471540.015
response to decreased oxygen levelsGO:0036293960.015
positive regulation of reactive oxygen species biosynthetic processGO:190342820.015
regulation of ion transmembrane transporter activityGO:0032412720.015
regulation of nucleotide biosynthetic processGO:0030808500.015
epithelium migrationGO:00901321190.015
cell aggregationGO:009874310.015
response to salt stressGO:000965130.015
regulation of actin filament based processGO:00329701410.015
negative regulation of protein modification processGO:00314002000.015
regulation of cell divisionGO:00513021160.015
cellular macromolecular complex assemblyGO:00346223240.015
anterior posterior axis specificationGO:000994820.015
positive regulation of reactive oxygen species metabolic processGO:2000379240.015
enzyme linked receptor protein signaling pathwayGO:00071673030.015
regulation of apoptotic signaling pathwayGO:20012331750.015
monosaccharide metabolic processGO:0005996740.015
regulation of multi organism processGO:00439001570.015
response to oxidative stressGO:00069791210.015
inorganic anion transportGO:0015698600.015
lipid transportGO:0006869900.015
wound healingGO:00420601150.015
ras protein signal transductionGO:0007265730.015
digestive system developmentGO:0055123750.014
actin cytoskeleton organizationGO:00300362070.014
compound eye developmentGO:004874910.014
neuron differentiationGO:00301821380.014
positive regulation of cell migrationGO:00303351720.014
positive regulation of nucleotide catabolic processGO:00308131850.014
regulation of transporter activityGO:0032409820.014
mitotic cell cycle processGO:19030472860.014
protein ubiquitinationGO:00165673140.014
thymus developmentGO:004853830.014
cellular response to growth factor stimulusGO:00713631970.014
protein localization to nucleusGO:00345041360.014
regulation of muscle system processGO:0090257530.014
positive regulation of apoptotic processGO:00430652460.014
nucleocytoplasmic transportGO:00069131760.014
response to peptide hormoneGO:0043434610.014
tissue regenerationGO:004224630.014
dna replicationGO:00062601160.014
skeletal system developmentGO:0001501790.014
associative learningGO:000830610.014
regulation of dna metabolic processGO:00510521530.014
gamma aminobutyric acid signaling pathwayGO:000721430.014
regulation of mitotic cell cycleGO:00073461890.014
response to extracellular stimulusGO:0009991850.014
Rat
adult locomotory behaviorGO:000834410.014
tissue morphogenesisGO:0048729960.014
morphogenesis of embryonic epitheliumGO:001633140.014
blood vessel developmentGO:00015681720.014
regulation of i kappab kinase nf kappab signalingGO:00431221620.014
dna repairGO:00062811980.014
regulation of blood volume by renin angiotensinGO:000201610.014
spermatid differentiationGO:004851540.014
ossificationGO:00015031210.014
positive regulation of purine nucleotide biosynthetic processGO:1900373380.014
multicellular organismal signalingGO:0035637340.014
posttranscriptional regulation of gene expressionGO:00106082130.014
peptide secretionGO:0002790510.014
protein oligomerizationGO:00512591730.014
i kappab kinase nf kappab signalingGO:00072491660.014
negative regulation of blood pressureGO:004577630.014
epithelial cell proliferationGO:00506731280.014
negative regulation of synaptic transmissionGO:005080520.014
cellular protein catabolic processGO:00442572610.014
positive regulation of secretionGO:00510471160.014
cellular carbohydrate metabolic processGO:0044262840.013
proteolysis involved in cellular protein catabolic processGO:00516032440.013
potassium ion importGO:001010790.013
cellular component disassemblyGO:0022411920.013
positive regulation of insulin like growth factor receptor signaling pathwayGO:004356840.013
heart processGO:0003015620.013
copulationGO:000762010.013
developmental programmed cell deathGO:001062330.013
amino acid transmembrane transportGO:0003333200.013
positive regulation of protein kinase activityGO:00458601900.013
receptor metabolic processGO:0043112810.013
defense response to fungusGO:005083240.013
regulation of blood circulationGO:1903522590.013
regulation of intracellular transportGO:00323861950.013
camp biosynthetic processGO:0006171470.013
positive regulation of secretion by cellGO:19035321080.013
sequestering of metal ionGO:0051238240.013
amino acid transportGO:0006865280.013
sequestering of calcium ionGO:0051208170.013
regulation of meiotic cell cycleGO:005144540.013
response to woundingGO:00096111680.013
chloride transportGO:0006821410.013
cytokinesisGO:0000910960.013
response to bacteriumGO:00096171440.013
Rat
cell substrate adhesionGO:00315891320.013
neuron fate commitmentGO:004866320.013
positive regulation of nucleoside metabolic processGO:00459791860.013
ribonucleoside monophosphate catabolic processGO:00091581580.013
hair follicle morphogenesisGO:003106920.013
negative regulation of neurological system processGO:003164520.013
response to corticotropin releasing hormoneGO:004343510.013
positive regulation of nucleotide biosynthetic processGO:0030810380.013
positive regulation of blood pressureGO:004577730.013
response to sucroseGO:000974410.013
syncytium formation by plasma membrane fusionGO:000076820.013
blastoderm segmentationGO:000735020.013
endocytosisGO:00068971590.013
response to hypoxiaGO:0001666960.013
regulation of cysteine type endopeptidase activityGO:20001161270.013
negative regulation of growthGO:0045926970.013

CYP17A1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
urinary system diseaseDOID:18400.077
kidney diseaseDOID:557360.077
nervous system diseaseDOID:8634310.049
Human
sensory system diseaseDOID:00501552030.049
Human
eye and adnexa diseaseDOID:14921500.049
Human
disease of metabolismDOID:00146672950.047
renal tubular transport diseaseDOID:447110.038
musculoskeletal system diseaseDOID:172230.035
eye diseaseDOID:56141490.031
Human
retinal diseaseDOID:56791180.031
Human
inherited metabolic disorderDOID:6552420.024
disease of cellular proliferationDOID:145661740.022
central nervous system diseaseDOID:3311860.020
cancerDOID:1621670.019
organ system cancerDOID:00506861640.018
retinal degenerationDOID:8466890.014
Human
acquired metabolic diseaseDOID:0060158580.013
cardiovascular system diseaseDOID:12871060.013