Homo sapiens

35 known processes

POLE4

polymerase (DNA-directed), epsilon 4 (p12 subunit)

(Aliases: YHHQ1,p12)

POLE4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
post embryonic developmentGO:000979120.287
covalent chromatin modificationGO:00165692540.191
internal peptidyl lysine acetylationGO:0018393970.138
protein acetylationGO:00064731160.114
cellular response to dna damage stimulusGO:00069743790.110
Yeast Fly
peptidyl lysine modificationGO:00182051440.110
nuclear migrationGO:000709710.109
histone modificationGO:00165702510.105
chromatin modificationGO:00165682980.101
histone acetylationGO:0016573930.091
chromatin organizationGO:00063253510.088
histone h3 acetylationGO:0043966450.079
dna repairGO:00062811980.074
Yeast
protein acylationGO:00435431380.072
establishment of nucleus localizationGO:004002310.069
dna dependent dna replicationGO:0006261440.064
Yeast
regulation of mitotic cell cycleGO:00073461890.061
response to oxygen containing compoundGO:19017003690.060
nucleus localizationGO:005164710.060
protein dna complex assemblyGO:0065004640.055
cellular macromolecule catabolic processGO:00442653800.054
cellular protein catabolic processGO:00442572610.051
response to abiotic stimulusGO:00096283360.050
centromere complex assemblyGO:0034508100.048
dna replication independent nucleosome assemblyGO:0006336270.047
histone exchangeGO:004348630.047
apoptotic signaling pathwayGO:00971902680.044
amine metabolic processGO:0009308440.043
reproductive processGO:00224141060.043
cellular macromolecular complex assemblyGO:00346223240.041
vesicle mediated transportGO:00161923710.041
nucleosome organizationGO:0034728660.039
response to radiationGO:00093141510.037
negative regulation of programmed cell deathGO:00430693210.036
negative regulation of apoptotic processGO:00430663160.036
protein ubiquitinationGO:00165673140.036
proteolysis involved in cellular protein catabolic processGO:00516032440.035
regulation of cellular amine metabolic processGO:0033238110.033
regulation of proteolysisGO:00301622930.033
single organism membrane organizationGO:00448022680.032
protein maturationGO:00516042330.032
mitotic cell cycle processGO:19030472860.032
positive regulation of cellular catabolic processGO:00313312840.031
mitochondrion organizationGO:00070051560.031
endocytosisGO:00068971590.030
negative regulation of cell deathGO:00605483450.030
negative regulation of cellular component organizationGO:00511292350.030
atp dependent chromatin remodelingGO:0043044250.030
regulation of peptidase activityGO:00525471800.029
purine ribonucleoside metabolic processGO:00461284370.028
single fertilizationGO:0007338110.028
regulation of cell cycle phase transitionGO:19019871260.027
cellular component morphogenesisGO:00329893140.027
cellular amine metabolic processGO:0044106410.027
dephosphorylationGO:00163112090.026
lipid metabolic processGO:00066293810.026
membrane organizationGO:00610242920.026
regulation of nucleotide metabolic processGO:00061402690.025
cellular response to abiotic stimulusGO:00712141170.025
positive regulation of cell deathGO:00109422630.025
positive regulation of catabolic processGO:00098963100.025
small molecule biosynthetic processGO:00442831570.024
protein localization to organelleGO:00333652800.024
regulation of transcription by chromatin organizationGO:003440110.024
cellular ketone metabolic processGO:0042180800.024
chromatin assembly or disassemblyGO:0006333780.024
apoptotic mitochondrial changesGO:0008637570.024
protein catabolic processGO:00301633250.024
positive regulation of programmed cell deathGO:00430682490.023
dna biosynthetic processGO:0071897400.023
Yeast
intrinsic apoptotic signaling pathwayGO:00971931270.023
single organism reproductive processGO:0044702980.023
protein modification by small protein conjugationGO:00324463420.023
locomotory behaviorGO:000762610.022
positive regulation of nucleotide metabolic processGO:00459812300.022
hindbrain developmentGO:003090230.022
protein targetingGO:00066051870.022
negative regulation of cellular protein metabolic processGO:00322693530.021
chromosome segregationGO:00070591140.021
protein dna complex subunit organizationGO:0071824800.021
ubiquitin dependent protein catabolic processGO:00065112060.021
dna replicationGO:00062601160.021
Yeast
dna replication independent nucleosome organizationGO:0034724270.021
cellular lipid metabolic processGO:00442553030.021
regulation of gene expression epigeneticGO:0040029730.020
Yeast
posttranscriptional regulation of gene expressionGO:00106082130.020
response to oxidative stressGO:00069791210.020
regulation of nucleoside metabolic processGO:00091182090.020
cellular response to oxygen containing compoundGO:19017012760.020
regulation of purine nucleotide metabolic processGO:19005422640.020
adult locomotory behaviorGO:000834410.020
positive regulation of transportGO:00510503360.020
regulation of cellular response to stressGO:00801352440.020
positive regulation of purine nucleotide metabolic processGO:19005442270.020
cellular response to radiationGO:0071478650.020
agingGO:0007568660.019
Yeast
cellular response to endogenous stimulusGO:00714953360.019
purine ribonucleoside triphosphate catabolic processGO:00092073910.019
modification dependent protein catabolic processGO:00199412090.019
positive regulation of apoptotic processGO:00430652460.019
positive regulation of cellular amino acid metabolic processGO:004576430.019
regulation of cellular amino acid metabolic processGO:000652160.018
chemical homeostasisGO:00488783060.018
heterochromatin organizationGO:007082860.018
Yeast
negative regulation of catalytic activityGO:00430863350.018
cell cycle phase transitionGO:00447701730.018
peptidyl lysine acetylationGO:00183941010.018
cation homeostasisGO:00550801890.018
negative regulation of hydrolase activityGO:00513461820.018
regulation of cellular component biogenesisGO:00440872810.018
regulation of protein processingGO:00706131500.018
release of cytochrome c from mitochondriaGO:0001836350.018
positive regulation of nucleoside metabolic processGO:00459791860.018
cytoplasmic transportGO:00164823790.018
gtp metabolic processGO:00460392390.017
embryo developmentGO:00097901230.017
reactive oxygen species metabolic processGO:0072593750.017
regulation of cell cycle processGO:00105642660.017
regulation of cellular ketone metabolic processGO:0010565500.017
defense responseGO:00069523150.016
epithelium developmentGO:00604292270.016
positive regulation of cellular amine metabolic processGO:003324070.016
actin filament based processGO:00300292240.016
regulation of apoptotic signaling pathwayGO:20012331750.016
cellular response to ionizing radiationGO:0071479320.016
protein processingGO:00164852260.016
regulation of sequence specific dna binding transcription factor activityGO:00510902110.016
organ formationGO:004864530.016
immune responseGO:00069553070.016
response to organic cyclic compoundGO:00140702040.016
chromatin remodeling at centromereGO:003105520.016
response to lipidGO:00339932060.016
dna templated transcription initiationGO:0006352350.015
organelle localizationGO:0051640840.015
negative regulation of protein metabolic processGO:00512483910.015
small gtpase mediated signal transductionGO:0007264780.015
regulation of wnt signaling pathwayGO:00301111230.015
transmembrane transportGO:00550853990.015
peripheral nervous system developmentGO:000742220.015
neurogenesisGO:00220081690.015
regulation of cysteine type endopeptidase activityGO:20001161270.015
ras protein signal transductionGO:0007265730.015
muscle contractionGO:0006936730.015
ion homeostasisGO:00508012300.015
response to ionizing radiationGO:0010212650.015
microtubule cytoskeleton organizationGO:00002261760.015
positive regulation of hydrolase activityGO:00513453310.014
female gamete generationGO:000729220.014
negative regulation of catabolic processGO:00098951040.014
guanosine containing compound catabolic processGO:19010692390.014
multicellular organismal agingGO:001025930.014
positive regulation of phosphorylationGO:00423273940.014
regulation of endopeptidase activityGO:00525481700.014
wnt signaling pathwayGO:00160551560.014
cell morphogenesisGO:00009022960.014
innate immune responseGO:00450871780.014
positive regulation of ion transportGO:0043270870.014
regulation of cell cycleGO:00517263930.014
regulation of protein catabolic processGO:00421761550.014
regulation of protein maturationGO:19033171500.014
positive regulation of cell proliferationGO:00082843010.014
regulation of transferase activityGO:00513383550.013
cell type specific apoptotic processGO:00972851250.013
regulation of protein localizationGO:00328802960.013
single organism cell adhesionGO:00986021790.013
regulation of mitotic cell cycle phase transitionGO:19019901180.013
fertilizationGO:0009566120.013
metal ion homeostasisGO:00550651690.013
negative regulation of cellular catabolic processGO:0031330830.013
ribonucleoside monophosphate metabolic processGO:00091611870.013
engulfment of apoptotic cellGO:004365220.013
regulation of protein modification by small protein conjugation or removalGO:19033201070.013
mapk cascadeGO:00001652880.013
oxidation reduction processGO:00551143960.013
reactive oxygen species biosynthetic processGO:190340940.013
cell adhesionGO:00071553250.013
negative regulation of organelle organizationGO:00106391260.013
protein importGO:00170381300.012
postreplication repairGO:0006301120.012
Yeast
regenerationGO:003109940.012
alcohol biosynthetic processGO:0046165520.012
establishment of protein localization to organelleGO:00725941720.012
rho protein signal transductionGO:0007266260.012
positive regulation of cytokine productionGO:00018191670.012
gtp catabolic processGO:00061842370.012
mitotic cell cycleGO:00002783260.012
cellular response to lipidGO:00713961270.012
dna recombinationGO:0006310770.012
negative regulation of cell cycleGO:00457861930.012
organic hydroxy compound metabolic processGO:19016151470.012
positive regulation of cellular component organizationGO:00511303760.012
internal protein amino acid acetylationGO:00064751010.012
response to external biotic stimulusGO:00432072610.012
ribonucleoside catabolic processGO:00424544060.012
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.012
guanosine containing compound metabolic processGO:19010682440.012
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.012
protein dephosphorylationGO:0006470810.012
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434710.012
autophagyGO:0006914880.012
modification dependent macromolecule catabolic processGO:00436322120.012
response to extracellular stimulusGO:0009991850.012
lipid biosynthetic processGO:00086101770.012
cytokine productionGO:00018162470.012
cellular response to organic cyclic compoundGO:00714071270.011
regulation of membrane potentialGO:0042391950.011
phospholipid metabolic processGO:0006644990.011
regulation of response to external stimulusGO:00321012220.011
positive regulation of protein transportGO:00512221350.011
organophosphate catabolic processGO:00464344300.011
positive regulation of endopeptidase activityGO:0010950840.011
cellular response to oxidative stressGO:0034599850.011
regulation of reactive oxygen species metabolic processGO:2000377410.011
biological adhesionGO:00226103310.011
regulation of mitochondrion organizationGO:0010821540.011
translesion synthesisGO:001998580.011
Yeast
nucleotide catabolic processGO:00091664080.011
negative regulation of protein processingGO:00109551420.011
positive regulation of reactive oxygen species metabolic processGO:2000379240.011
determination of adult lifespanGO:000834020.011
regulation of establishment of protein localizationGO:00702012420.011
response to reactive oxygen speciesGO:0000302610.011
microtubule based processGO:00070172100.011
signal transduction by phosphorylationGO:00230142970.011
negative regulation of immune system processGO:00026831360.011
response to biotic stimulusGO:00096072760.011
glycerophospholipid metabolic processGO:0006650840.011
regulation of cellular protein catabolic processGO:1903362960.011
regulation of gtpase activityGO:00430871800.011
regulation of cytokine productionGO:00018172320.011
canonical wnt signaling pathwayGO:00600701160.011
purine ribonucleoside triphosphate metabolic processGO:00092054110.011
methylationGO:00322591060.011
negative regulation of protein maturationGO:19033181420.010
positive regulation of gtpase activityGO:00435471660.010
replicative senescenceGO:009039980.010
Yeast
neuromuscular junction developmentGO:000752830.010
positive regulation of purine nucleotide catabolic processGO:00331231850.010
single organism cellular localizationGO:19025803320.010
cellular response to extracellular stimulusGO:0031668720.010
metal ion transportGO:00300012720.010
regulation of reactive oxygen species biosynthetic processGO:190342630.010
negative regulation of intracellular signal transductionGO:19025321830.010
negative regulation of phosphorus metabolic processGO:00105632670.010
morphogenesis of embryonic epitheliumGO:001633140.010
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.010
regulation of bindingGO:00510981110.010
dna packagingGO:0006323770.010

POLE4 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:145661740.033
cancerDOID:1621670.020
organ system cancerDOID:00506861640.020
disease of metabolismDOID:00146672950.012
sensory system diseaseDOID:00501552030.012
nervous system diseaseDOID:8634310.012
eye and adnexa diseaseDOID:14921500.010