Homo sapiens

12 known processes

PMEL

premelanosome protein

(Aliases: P1,SILV,ME20,PMEL17,gp100,ME20M,P100,SI,ME20-M,D12S53E,SIL)

PMEL biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
lipid metabolic processGO:00066293810.170
cellular lipid metabolic processGO:00442553030.087
response to oxygen containing compoundGO:19017003690.087
system processGO:00030083490.069
cellular amine metabolic processGO:0044106410.066
post embryonic developmentGO:000979120.057
response to abiotic stimulusGO:00096283360.055
amine metabolic processGO:0009308440.054
cellular amino acid metabolic processGO:00065201160.053
regulation of cellular amino acid metabolic processGO:000652160.051
oxidation reduction processGO:00551143960.051
cell adhesionGO:00071553250.049
cellular ketone metabolic processGO:0042180800.048
chemical homeostasisGO:00488783060.048
negative regulation of protein metabolic processGO:00512483910.046
transmembrane transportGO:00550853990.045
regulation of protein localizationGO:00328802960.045
biological adhesionGO:00226103310.045
positive regulation of cellular component organizationGO:00511303760.044
regulation of cellular ketone metabolic processGO:0010565500.042
regulation of establishment of protein localizationGO:00702012420.042
cytoplasmic transportGO:00164823790.041
regulation of cellular component movementGO:00512703340.041
regulation of cell differentiationGO:00455953930.041
negative regulation of cellular protein metabolic processGO:00322693530.041
epithelium developmentGO:00604292270.040
secretionGO:00469032540.040
regulation of cellular amine metabolic processGO:0033238110.040
monocarboxylic acid metabolic processGO:00327871850.040
immune responseGO:00069553070.040
anion transportGO:00068201610.039
positive regulation of cellular amine metabolic processGO:003324070.038
negative regulation of catalytic activityGO:00430863350.038
negative regulation of multicellular organismal processGO:00512413170.038
negative regulation of cell deathGO:00605483450.037
small gtpase mediated signal transductionGO:0007264780.037
protein catabolic processGO:00301633250.037
female gamete generationGO:000729220.036
epidermis morphogenesisGO:004873030.036
regulation of cell motilityGO:20001452990.036
response to biotic stimulusGO:00096072760.036
regulation of cellular component biogenesisGO:00440872810.036
actin filament based processGO:00300292240.036
regulation of protein transportGO:00512232130.035
response to lipidGO:00339932060.034
positive regulation of cellular amino acid metabolic processGO:004576430.034
ion homeostasisGO:00508012300.034
positive regulation of transportGO:00510503360.034
cell developmentGO:00484683280.034
positive regulation of catabolic processGO:00098963100.034
cellular macromolecule catabolic processGO:00442653800.034
locomotory behaviorGO:000762610.033
ras protein signal transductionGO:0007265730.033
secretion by cellGO:00329402260.033
regulation of secretionGO:00510461940.033
oogenesisGO:004847720.033
determination of adult lifespanGO:000834020.033
regulation of secretion by cellGO:19035301770.033
multicellular organismal agingGO:001025930.033
ribonucleotide catabolic processGO:00092614050.033
nucleoside catabolic processGO:00091644080.032
regulation of cell cycleGO:00517263930.031
vesicle mediated transportGO:00161923710.031
positive regulation of immune system processGO:00026842830.031
regenerationGO:003109940.031
neurological system processGO:00508771630.031
cellular component morphogenesisGO:00329893140.031
negative regulation of cellular component organizationGO:00511292350.031
protein localization to organelleGO:00333652800.030
protein maturationGO:00516042330.030
keratinizationGO:003142420.030
negative regulation of programmed cell deathGO:00430693210.030
cytokine productionGO:00018162470.030
purine nucleoside triphosphate metabolic processGO:00091444120.030
positive regulation of cellular catabolic processGO:00313312840.029
protein modification by small protein conjugationGO:00324463420.029
regulation of transferase activityGO:00513383550.029
defense responseGO:00069523150.029
purine nucleotide catabolic processGO:00061954050.029
negative regulation of apoptotic processGO:00430663160.029
ribonucleoside catabolic processGO:00424544060.029
cation transportGO:00068123310.029
nucleoside triphosphate metabolic processGO:00091414220.028
purine containing compound catabolic processGO:00725234110.028
regulation of locomotionGO:00400123290.028
positive regulation of cell proliferationGO:00082843010.028
purine ribonucleotide catabolic processGO:00091544040.028
ribonucleoside triphosphate catabolic processGO:00092033910.028
purine ribonucleoside metabolic processGO:00461284370.028
regulation of cytokine productionGO:00018172320.028
nerve developmentGO:002167540.028
regulation of response to external stimulusGO:00321012220.028
epithelial cell differentiationGO:00308551410.028
nucleoside phosphate catabolic processGO:19012924120.027
cell morphogenesisGO:00009022960.027
response to hormoneGO:00097251750.027
fatty acid metabolic processGO:00066311150.027
organonitrogen compound biosynthetic processGO:19015662000.027
sensory perceptionGO:00076001030.027
cellular response to endogenous stimulusGO:00714953360.027
small molecule biosynthetic processGO:00442831570.027
negative regulation of phosphate metabolic processGO:00459362670.027
ion transmembrane transportGO:00342203380.027
lipid biosynthetic processGO:00086101770.027
cellular macromolecular complex assemblyGO:00346223240.027
glycosyl compound catabolic processGO:19016584130.027
cellular homeostasisGO:00197251960.027
steroid metabolic processGO:0008202940.026
intracellular protein transportGO:00068862700.026
positive regulation of hydrolase activityGO:00513453310.026
anatomical structure formation involved in morphogenesisGO:00486462840.026
regulation of anatomical structure morphogenesisGO:00226032860.026
response to organic cyclic compoundGO:00140702040.026
purine ribonucleoside triphosphate catabolic processGO:00092073910.026
alcohol metabolic processGO:00060661140.026
protein ubiquitinationGO:00165673140.026
neuromuscular junction developmentGO:000752830.026
rho protein signal transductionGO:0007266260.025
organic hydroxy compound metabolic processGO:19016151470.025
ribonucleoside triphosphate metabolic processGO:00091994120.025
membrane organizationGO:00610242920.025
inner ear morphogenesisGO:004247240.025
negative regulation of phosphorus metabolic processGO:00105632670.025
carbohydrate metabolic processGO:00059752070.025
lipid catabolic processGO:0016042840.025
regulation of proteolysisGO:00301622930.025
single organism membrane organizationGO:00448022680.025
single organism cellular localizationGO:19025803320.024
nucleotide catabolic processGO:00091664080.024
nucleoside triphosphate catabolic processGO:00091433940.024
positive regulation of phosphorylationGO:00423273940.024
innate immune responseGO:00450871780.024
purine nucleoside triphosphate catabolic processGO:00091463920.024
metal ion transportGO:00300012720.024
regulation of sequence specific dna binding transcription factor activityGO:00510902110.024
enzyme linked receptor protein signaling pathwayGO:00071673030.024
matingGO:000761810.023
organophosphate catabolic processGO:00464344300.023
negative regulation of protein modification processGO:00314002000.023
purine nucleoside catabolic processGO:00061523980.023
regulation of immune responseGO:00507762010.023
positive regulation of locomotionGO:00400171860.023
segmentationGO:003528240.023
cellular response to oxygen containing compoundGO:19017012760.023
mapk cascadeGO:00001652880.023
negative regulation of intracellular signal transductionGO:19025321830.023
response to external biotic stimulusGO:00432072610.022
cellular protein catabolic processGO:00442572610.022
purine ribonucleoside catabolic processGO:00461303980.022
purine ribonucleoside triphosphate metabolic processGO:00092054110.022
cation homeostasisGO:00550801890.022
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.022
positive regulation of protein transportGO:00512221350.022
carbohydrate derivative biosynthetic processGO:19011372070.022
skin developmentGO:0043588760.022
regulation of cytoskeleton organizationGO:00514931770.022
apoptotic signaling pathwayGO:00971902680.022
cellular chemical homeostasisGO:00550821800.022
positive regulation of cellular component movementGO:00512721810.021
regulation of purine nucleotide catabolic processGO:00331212050.021
response to radiationGO:00093141510.021
regulation of protein kinase activityGO:00458592890.021
regulation of intracellular protein transportGO:00331571230.021
response to other organismGO:00517072610.021
regulation of cell cycle processGO:00105642660.021
copulationGO:000762010.021
regulation of cell migrationGO:00303342890.021
mitotic cell cycleGO:00002783260.021
regulation of reactive oxygen species metabolic processGO:2000377410.021
somatic stem cell maintenanceGO:003501940.021
single organism carbohydrate metabolic processGO:00447231930.021
signal transduction by phosphorylationGO:00230142970.021
protein processingGO:00164852260.021
organelle assemblyGO:00709251760.021
nuclear transportGO:00511691790.021
regulation of mapk cascadeGO:00434082620.020
nervous system developmentGO:00073992930.020
regulation of intracellular transportGO:00323861950.020
ossificationGO:00015031210.020
negative regulation of developmental processGO:00510932470.020
blastoderm segmentationGO:000735020.020
guanosine containing compound catabolic processGO:19010692390.020
positive regulation of developmental processGO:00510943140.020
regulation of apoptotic signaling pathwayGO:20012331750.019
tissue migrationGO:00901301190.019
negative regulation of cellular amine metabolic processGO:003323930.019
metal ion homeostasisGO:00550651690.019
cell projection organizationGO:00300302520.019
inorganic cation transmembrane transportGO:00986621940.019
regulation of kinase activityGO:00435493140.019
regulation of cell adhesionGO:00301551660.019
reactive oxygen species metabolic processGO:0072593750.019
positive regulation of cell deathGO:00109422630.019
negative regulation of phosphorylationGO:00423261740.019
covalent chromatin modificationGO:00165692540.019
actin cytoskeleton organizationGO:00300362070.019
protein targetingGO:00066051870.019
organic acid biosynthetic processGO:0016053970.018
inorganic ion transmembrane transportGO:00986602310.018
response to inorganic substanceGO:00100351270.018
morphogenesis of embryonic epitheliumGO:001633140.018
epithelial cell migrationGO:00106311190.018
regulation of cytoplasmic transportGO:19036491490.018
positive regulation of cytokine productionGO:00018191670.018
nucleocytoplasmic transportGO:00069131760.018
memoryGO:000761330.018
cardiovascular system developmentGO:00723582620.018
cell growthGO:00160491600.018
cardiac muscle cell contractionGO:008600340.018
reactive oxygen species biosynthetic processGO:190340940.018
regulation of cell developmentGO:00602841610.018
proteolysis involved in cellular protein catabolic processGO:00516032440.018
cell divisionGO:00513011680.018
epithelium migrationGO:00901321190.018
positive regulation of cell motilityGO:20001471770.018
response to cytokineGO:00340972320.018
reactive nitrogen species metabolic processGO:200105730.018
positive regulation of programmed cell deathGO:00430682490.018
posttranscriptional regulation of gene expressionGO:00106082130.018
cellular response to organic cyclic compoundGO:00714071270.018
cellular response to lipidGO:00713961270.018
chromatin organizationGO:00063253510.018
positive regulation of apoptotic processGO:00430652460.017
cellular cation homeostasisGO:00300031630.017
lipid modificationGO:0030258840.017
nitrogen compound transportGO:00717051910.017
epidermis developmentGO:0008544590.017
regulation of peptidase activityGO:00525471800.017
positive regulation of organelle organizationGO:00106381950.017
positive regulation of immune responseGO:00507781590.017
cardiac muscle contractionGO:0060048340.017
purine ribonucleoside monophosphate metabolic processGO:00091671860.017
neurotransmitter secretionGO:000726940.017
associative learningGO:000830610.017
cellular protein complex assemblyGO:00436231880.017
regulation of cellular response to stressGO:00801352440.017
positive regulation of cell differentiationGO:00455972110.017
response to bacteriumGO:00096171440.017
regulation of lipid metabolic processGO:0019216960.017
activation of immune responseGO:00022531140.017
peripheral nervous system developmentGO:000742220.017
cation transmembrane transportGO:00986552380.017
carboxylic acid biosynthetic processGO:0046394970.017
modification dependent macromolecule catabolic processGO:00436322120.017
regulation of mitotic cell cycleGO:00073461890.017
small molecule catabolic processGO:0044282920.017
oocyte developmentGO:004859910.016
spermatid differentiationGO:004851540.016
endomembrane system organizationGO:00102561960.016
circulatory system developmentGO:00723592620.016
hindbrain developmentGO:003090230.016
regulation of nucleoside metabolic processGO:00091182090.016
regulation of defense responseGO:00313471540.016
regulation of synaptic plasticityGO:004816730.016
negative regulation of protein phosphorylationGO:00019331400.016
positive regulation of purine nucleotide catabolic processGO:00331231850.016
dephosphorylationGO:00163112090.016
positive regulation of purine nucleotide metabolic processGO:19005442270.016
negative regulation of cellular amino acid metabolic processGO:004576320.016
cell activationGO:00017752130.016
establishment of protein localization to organelleGO:00725941720.016
regulation of reactive oxygen species biosynthetic processGO:190342630.016
ubiquitin dependent protein catabolic processGO:00065112060.016
adult locomotory behaviorGO:000834410.016
positive regulation of cellular component biogenesisGO:00440891580.016
sulfur compound metabolic processGO:00067901010.016
osteoblast differentiationGO:0001649920.016
cellular response to dna damage stimulusGO:00069743790.016
hormone metabolic processGO:0042445610.016
limbic system developmentGO:002176130.016
response to growth factorGO:00708482050.015
cellular response to abiotic stimulusGO:00712141170.015
cell cell signalingGO:00072671550.015
negative regulation of cell differentiationGO:00455961710.015
gtp metabolic processGO:00460392390.015
regulation of protein serine threonine kinase activityGO:00719001790.015
regulation of hormone levelsGO:00108171250.015
compound eye developmentGO:004874910.015
chromatin modificationGO:00165682980.015
protein oligomerizationGO:00512591730.015
response to axon injuryGO:004867810.015
regulation of protein maturationGO:19033171500.015
defense response to fungusGO:005083240.015
organic anion transportGO:00157111030.015
regulation of small gtpase mediated signal transductionGO:00510561560.015
protein localization to nucleusGO:00345041360.015
negative regulation of organelle organizationGO:00106391260.015
histone modificationGO:00165702510.015
ectodermal placode developmentGO:007169610.015
negative regulation of transferase activityGO:00513481240.015
negative regulation of transportGO:00510511760.015
syncytium formation by plasma membrane fusionGO:000076820.015
negative regulation of hydrolase activityGO:00513461820.015
response to oxygen levelsGO:00704821000.015
regulation of cell morphogenesisGO:00226041530.015
oocyte differentiationGO:000999420.015
morphogenesis of a polarized epitheliumGO:000173830.015
cellular ion homeostasisGO:00068731680.015
maintenance of locationGO:00512351120.015
microtubule based processGO:00070172100.015
regulation of nucleotide catabolic processGO:00308112050.015
positive regulation of cell migrationGO:00303351720.014
positive regulation of reactive oxygen species biosynthetic processGO:190342820.014
regulation of body fluid levelsGO:0050878990.014
spermatid developmentGO:000728640.014
regulation of protein secretionGO:0050708860.014
response to fungusGO:000962040.014
modification dependent protein catabolic processGO:00199412090.014
positive regulation of secretionGO:00510471160.014
positive regulation of protein phosphorylationGO:00019343130.014
regulation of protein catabolic processGO:00421761550.014
regulation of purine nucleotide metabolic processGO:19005422640.014
wnt signaling pathwayGO:00160551560.014
negative regulation of protein processingGO:00109551420.014
gtp catabolic processGO:00061842370.014
epithelial cell proliferationGO:00506731280.014
regulation of cell growthGO:00015581350.014
monovalent inorganic cation transportGO:00156721280.014
hair follicle morphogenesisGO:003106920.014
negative regulation of cell proliferationGO:00082852280.014
regulation of membrane potentialGO:0042391950.014
regulation of protein processingGO:00706131500.014
protein secretionGO:0009306980.014
circulatory system processGO:00030131130.014
positive regulation of transferase activityGO:00513472270.014
growthGO:00400072020.014
cellular response to cytokine stimulusGO:00713451810.014
organ morphogenesisGO:00098871470.014
proteasomal protein catabolic processGO:00104981760.014
motor neuron axon guidanceGO:000804520.014
striated muscle contractionGO:0006941520.014
glycerolipid metabolic processGO:00464861070.014
response to decreased oxygen levelsGO:0036293960.014
positive regulation of reactive oxygen species metabolic processGO:2000379240.014
endosomal transportGO:00161971290.014
positive regulation of mapk cascadeGO:00434101900.014
lipid localizationGO:00108761060.014
positive regulation of steroid hormone biosynthetic processGO:009003120.013
multicellular organismal homeostasisGO:0048871670.013
regulation of protein complex assemblyGO:00432541470.013
positive regulation of nucleoside metabolic processGO:00459791860.013
regulation of multi organism processGO:00439001570.013
cell fate determinationGO:000170930.013
regulation of vesicle mediated transportGO:00606271300.013
organic acid catabolic processGO:0016054710.013
protein importGO:00170381300.013
negative regulation of cell cycleGO:00457861930.013
phospholipid metabolic processGO:0006644990.013
regulation of cysteine type endopeptidase activityGO:20001161270.013
divalent inorganic cation transportGO:00725111580.013
response to woundingGO:00096111680.013
protein localization to membraneGO:00726571600.013
response to light stimulusGO:0009416870.013
establishment of protein localization to membraneGO:00901501210.013
cellular lipid catabolic processGO:0044242650.013
regulation of dna metabolic processGO:00510521530.013
tissue regenerationGO:004224630.013
generation of neuronsGO:00486991520.013
cellular response to growth factor stimulusGO:00713631970.013
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.013
organelle fissionGO:00482851490.013
guanosine containing compound metabolic processGO:19010682440.013
mitotic cell cycle processGO:19030472860.013
embryonic epithelial tube formationGO:000183840.013
response to nitrogen compoundGO:19016981840.013
blood circulationGO:00080151130.013
multicellular organismal response to stressGO:003355510.013
photoreceptor cell differentiationGO:004653020.013
endocytosisGO:00068971590.013
myoblast fusionGO:000752010.013
lipid transportGO:0006869900.013
actin filament organizationGO:00070151280.013
muscle contractionGO:0006936730.013
response to nutrient levelsGO:0031667810.013
plasma membrane organizationGO:00070091150.013
regulation of endopeptidase activityGO:00525481700.013
single organism cell adhesionGO:00986021790.013
regulation of protein modification by small protein conjugation or removalGO:19033201070.013
regulation of neurotransmitter secretionGO:004692830.013
cell cell junction organizationGO:0045216690.013
mitochondrion organizationGO:00070051560.013
regulation of nucleotide metabolic processGO:00061402690.013
regulation of i kappab kinase nf kappab signalingGO:00431221620.013
intracellular receptor signaling pathwayGO:00305221040.013
leukocyte activationGO:00453211640.013
positive regulation of secretion by cellGO:19035321080.013
negative regulation of kinase activityGO:00336731060.013
regulation of gtp catabolic processGO:00331241800.013
cellular calcium ion homeostasisGO:00068741170.013
metencephalon developmentGO:002203720.013
anterior posterior axis specificationGO:000994820.012
actin mediated cell contractionGO:0070252120.012
cerebellum developmentGO:002154920.012
positive regulation of proteolysisGO:00458621420.012
nuclear importGO:00511701060.012
regulation of wnt signaling pathwayGO:00301111230.012
icosanoid metabolic processGO:0006690350.012
defense response to other organismGO:00985421290.012
response to organonitrogen compoundGO:00102431560.012
rna processingGO:00063962550.012
unsaturated fatty acid metabolic processGO:0033559370.012
regulation of meiotic cell cycleGO:005144540.012
meiotic chromosome segregationGO:004513240.012
regulation of feeding behaviorGO:006025930.012
divalent inorganic cation homeostasisGO:00725071360.012
regulation of anatomical structure sizeGO:00900661010.012
cellular modified amino acid metabolic processGO:0006575640.012
microtubule cytoskeleton organizationGO:00002261760.012
positive regulation of nucleotide catabolic processGO:00308131850.012
i kappab kinase nf kappab signalingGO:00072491660.012
cellular component disassemblyGO:0022411920.012
atp metabolic processGO:00460341760.012
developmental programmed cell deathGO:001062330.012
rhythmic behaviorGO:000762220.012
cell junction organizationGO:0034330790.012
peptidyl tyrosine modificationGO:00182121700.012
regulation of growthGO:00400081650.012
regulation of bindingGO:00510981110.012
negative regulation of protein kinase activityGO:0006469980.012
positive regulation of gtpase activityGO:00435471660.012
glycoprotein metabolic processGO:00091001100.012
purine nucleoside monophosphate metabolic processGO:00091261860.012
cytokine secretionGO:0050663640.012
multi organism cellular processGO:00447641560.012
zymogen activationGO:0031638700.012
calcium ion homeostasisGO:00550741220.012
meiosis iGO:000712740.012
cell substrate adhesionGO:00315891320.012
embryonic placenta developmentGO:000189210.012
stem cell divisionGO:001714520.012
negative regulation of apoptotic signaling pathwayGO:2001234970.012
organic hydroxy compound biosynthetic processGO:1901617710.012
response to oxidative stressGO:00069791210.012
actin filament based movementGO:0030048170.012
regulation of protein targetingGO:1903533910.012
cellular response to hypoxiaGO:0071456510.012
response to extracellular stimulusGO:0009991850.012
anterior posterior axis specification embryoGO:000859520.012
mesendoderm developmentGO:004838210.012
cellular metal ion homeostasisGO:00068751460.012
protein acylationGO:00435431380.012
cranial nerve developmentGO:002154540.012
positive regulation of defense responseGO:0031349870.012
vasculature developmentGO:00019441810.012
nucleoside monophosphate metabolic processGO:00091231910.012
ameboidal type cell migrationGO:00016671350.012
peptidyl tyrosine phosphorylationGO:00181081700.012
regulation of actin filament based processGO:00329701410.012
response to metal ionGO:0010038840.012
negative regulation of protein maturationGO:19033181420.011
glycerophospholipid metabolic processGO:0006650840.011
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.011
ribonucleoside monophosphate metabolic processGO:00091611870.011
blood vessel morphogenesisGO:00485141620.011
negative regulation of proteolysisGO:00458611320.011
regulation of gtpase activityGO:00430871800.011
regulation of neural precursor cell proliferationGO:200017740.011
immune effector processGO:00022521590.011
immune system developmentGO:00025201950.011
regulation of cell divisionGO:00513021160.011
neural tube formationGO:000184130.011
cell cycle phase transitionGO:00447701730.011
regulation of protein ubiquitinationGO:0031396950.011
neuron projection regenerationGO:003110210.011
regulation of actin cytoskeleton organizationGO:00329561160.011
cell part morphogenesisGO:00329901370.011
inseminationGO:000732010.011
response to hypoxiaGO:0001666960.011
neurogenesisGO:00220081690.011
protein polymerizationGO:0051258710.011

PMEL disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.060
inherited metabolic disorderDOID:6552420.047
nervous system diseaseDOID:8634310.046
sensory system diseaseDOID:00501552030.046
retinal diseaseDOID:56791180.033
eye diseaseDOID:56141490.033
eye and adnexa diseaseDOID:14921500.033
disease of cellular proliferationDOID:145661740.022
cancerDOID:1621670.022
central nervous system diseaseDOID:3311860.021
musculoskeletal system diseaseDOID:172230.020
connective tissue diseaseDOID:651090.020
organ system cancerDOID:00506861640.020
immune system diseaseDOID:29141550.020
bone diseaseDOID:0080001880.019
retinal degenerationDOID:8466890.017
neurodegenerative diseaseDOID:12891020.015
hematopoietic system diseaseDOID:741000.015
neuropathyDOID:870520.013
bone development diseaseDOID:0080006550.012
osteochondrodysplasiaDOID:2256350.012
disease of mental healthDOID:150700.012
night blindnessDOID:8499100.011