Homo sapiens

23 known processes

UBE3A

ubiquitin protein ligase E3A

(Aliases: E6-AP,FLJ26981,AS,HPVE6A,EPVE6AP,ANCR)

UBE3A biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
protein ubiquitinationGO:00165673141.000
protein modification by small protein conjugationGO:00324463421.000
protein polyubiquitinationGO:00002091100.999
cellular protein catabolic processGO:00442572610.996
Mouse Fly
modification dependent protein catabolic processGO:00199412090.962
Mouse Fly
proteolysis involved in cellular protein catabolic processGO:00516032440.950
Mouse Fly
negative regulation of cell cycleGO:00457861930.948
cellular macromolecule catabolic processGO:00442653800.947
Mouse Fly
ubiquitin dependent protein catabolic processGO:00065112060.939
Mouse Fly
cellular response to dna damage stimulusGO:00069743790.917
protein k48 linked ubiquitinationGO:0070936380.916
chromatin modificationGO:00165682980.784
protein catabolic processGO:00301633250.774
Mouse Fly
regulation of canonical wnt signaling pathwayGO:0060828880.757
female gamete generationGO:000729220.741
cellular response to oxidative stressGO:0034599850.738
regulation of intrinsic apoptotic signaling pathwayGO:2001242720.722
enzyme linked receptor protein signaling pathwayGO:00071673030.721
post embryonic developmentGO:000979120.692
regulation of wnt signaling pathwayGO:00301111230.691
positive regulation of cell proliferationGO:00082843010.662
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.656
apoptotic signaling pathwayGO:00971902680.649
canonical wnt signaling pathwayGO:00600701160.645
regulation of cell cycleGO:00517263930.641
histone acetylationGO:0016573930.630
cell cycle phase transitionGO:00447701730.628
internal peptidyl lysine acetylationGO:0018393970.590
intrinsic apoptotic signaling pathwayGO:00971931270.582
chromatin organizationGO:00063253510.582
covalent chromatin modificationGO:00165692540.578
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.542
internal protein amino acid acetylationGO:00064751010.486
regulation of cellular response to stressGO:00801352440.479
histone modificationGO:00165702510.470
protein acetylationGO:00064731160.467
negative regulation of mitotic cell cycleGO:00459301020.450
cell developmentGO:00484683280.446
Fly
negative regulation of cell deathGO:00605483450.408
regulation of cell cycle phase transitionGO:19019871260.408
cellular macromolecular complex assemblyGO:00346223240.407
regulation of cell cycle processGO:00105642660.406
wnt signaling pathwayGO:00160551560.389
mitotic cell cycleGO:00002783260.388
growthGO:00400072020.372
Mouse
multicellular organismal agingGO:001025930.370
protein autoubiquitinationGO:0051865370.357
regulation of proteolysisGO:00301622930.356
Fly
negative regulation of cell cycle processGO:00109481210.355
regulation of apoptotic signaling pathwayGO:20012331750.335
protein ubiquitination involved in ubiquitin dependent protein catabolic processGO:0042787370.333
Fly
dna repairGO:00062811980.327
peptidyl lysine acetylationGO:00183941010.321
negative regulation of mitotic cell cycle phase transitionGO:1901991850.311
histone h3 acetylationGO:0043966450.292
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.282
oogenesisGO:004847720.252
regulation of cell growthGO:00015581350.249
protein oligomerizationGO:00512591730.230
regulation of cellular ketone metabolic processGO:0010565500.228
mitotic cell cycle processGO:19030472860.217
response to radiationGO:00093141510.215
cell death in response to oxidative stressGO:0036473290.215
mapk cascadeGO:00001652880.207
cell agingGO:0007569520.206
regulation of protein maturationGO:19033171500.200
negative regulation of cell cycle phase transitionGO:1901988890.196
response to abiotic stimulusGO:00096283360.188
regulation of mitotic cell cycle phase transitionGO:19019901180.186
double strand break repairGO:00063021010.185
regulation of protein modification by small protein conjugation or removalGO:19033201070.184
Fly
modification dependent macromolecule catabolic processGO:00436322120.181
Mouse Fly
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434710.179
positive regulation of protein modification by small protein conjugation or removalGO:1903322610.178
Fly
cellular response to abiotic stimulusGO:00712141170.174
regulation of cell differentiationGO:00455953930.174
regulation of neuron differentiationGO:0045664700.171
regulation of cellular protein catabolic processGO:1903362960.162
Fly
regulation of endopeptidase activityGO:00525481700.160
negative regulation of programmed cell deathGO:00430693210.160
cellular amino acid metabolic processGO:00065201160.156
regulation of response to dna damage stimulusGO:2001020940.154
morphogenesis of embryonic epitheliumGO:001633140.153
regulation of mitotic cell cycleGO:00073461890.152
proteasomal protein catabolic processGO:00104981760.152
regulation of proteasomal protein catabolic processGO:0061136870.150
regulation of neurogenesisGO:0050767820.147
embryonic epithelial tube formationGO:000183840.146
protein acylationGO:00435431380.146
regulation of peptidase activityGO:00525471800.142
regulation of oxidative stress induced cell deathGO:1903201240.141
negative regulation of protein processingGO:00109551420.140
establishment or maintenance of epithelial cell apical basal polarityGO:004519710.139
cell growthGO:00160491600.136
generation of neuronsGO:00486991520.136
Fly
determination of adult lifespanGO:000834020.132
negative regulation of catalytic activityGO:00430863350.131
protein maturationGO:00516042330.130
peptidyl lysine modificationGO:00182051440.129
histone h4 acetylationGO:0043967470.128
mitotic cell cycle checkpointGO:0007093680.122
negative regulation of cellular protein metabolic processGO:00322693530.120
positive regulation of ligase activityGO:0051351190.119
protein deubiquitinationGO:0016579790.119
regulation of protein catabolic processGO:00421761550.115
Fly
regulation of cell cycle g1 s phase transitionGO:1902806420.115
regulation of mapk cascadeGO:00434082620.114
negative regulation of cellular component organizationGO:00511292350.109
negative regulation of protein maturationGO:19033181420.104
cellular senescenceGO:0090398340.101
single organism nuclear importGO:19025931040.100
signal transduction by phosphorylationGO:00230142970.094
negative regulation of g1 s transition of mitotic cell cycleGO:2000134290.094
cell cycle checkpointGO:00000751170.093
regulation of response to oxidative stressGO:1902882260.093
erbb signaling pathwayGO:0038127440.092
regulation of anatomical structure morphogenesisGO:00226032860.090
cell morphogenesis involved in differentiationGO:00009041440.089
Fly
regulation of protein ubiquitinationGO:0031396950.089
Fly
negative regulation of cellular catabolic processGO:0031330830.087
autophagyGO:0006914880.087
negative regulation of cell developmentGO:0010721480.087
protein targeting to nucleusGO:00447441040.086
neural tube formationGO:000184130.082
mitotic dna integrity checkpointGO:0044774300.080
negative regulation of cell cycle g1 s phase transitionGO:1902807290.080
regulation of protein complex assemblyGO:00432541470.078
response to decreased oxygen levelsGO:0036293960.077
negative regulation of multicellular organismal processGO:00512413170.077
regulation of cellular amino acid metabolic processGO:000652160.077
regulation of nervous system developmentGO:0051960880.076
regulation of growthGO:00400081650.076
regulation of cellular amine metabolic processGO:0033238110.076
amine metabolic processGO:0009308440.076
cellular response to external stimulusGO:00714961110.076
transmembrane transportGO:00550853990.075
ras protein signal transductionGO:0007265730.075
g1 s transition of mitotic cell cycleGO:0000082780.075
negative regulation of proteolysisGO:00458611320.074
regulation of g1 s transition of mitotic cell cycleGO:2000045400.074
embryonic morphogenesisGO:0048598850.071
protein processingGO:00164852260.070
oocyte differentiationGO:000999420.069
regulation of cell morphogenesisGO:00226041530.069
protein importGO:00170381300.068
negative regulation of intracellular signal transductionGO:19025321830.068
positive regulation of transferase activityGO:00513472270.067
microtubule cytoskeleton organizationGO:00002261760.067
positive regulation of protein ubiquitinationGO:0031398530.067
Fly
regulation of cell developmentGO:00602841610.066
regulation of cellular component biogenesisGO:00440872810.065
negative regulation of peptidase activityGO:0010466910.063
cellular ketone metabolic processGO:0042180800.063
histone h4 k12 acetylationGO:004398360.061
posttranscriptional regulation of gene expressionGO:00106082130.060
negative regulation of apoptotic processGO:00430663160.057
mitotic dna damage checkpointGO:0044773280.057
establishment of planar polarityGO:000173630.057
single organism cellular localizationGO:19025803320.055
meiotic chromosome segregationGO:004513240.055
negative regulation of autophagyGO:0010507140.054
positive regulation of cellular catabolic processGO:00313312840.053
Fly
negative regulation of apoptotic signaling pathwayGO:2001234970.052
nuclear importGO:00511701060.052
chromosome segregationGO:00070591140.051
amide transportGO:0042886760.051
nervous system developmentGO:00073992930.050
Fly
positive regulation of protein complex assemblyGO:0031334860.050
organ morphogenesisGO:00098871470.049
negative regulation of neuron differentiationGO:0045665210.049
cellular response to extracellular stimulusGO:0031668720.048
inner ear morphogenesisGO:004247240.046
response to nutrient levelsGO:0031667810.046
negative regulation of neurogenesisGO:0050768260.045
regulation of protein targetingGO:1903533910.044
response to ionizing radiationGO:0010212650.044
cell cycle g1 s phase transitionGO:0044843800.044
defense responseGO:00069523150.043
positive regulation of dna metabolic processGO:0051054730.043
negative regulation of cellular amino acid metabolic processGO:004576320.043
negative regulation of intrinsic apoptotic signaling pathwayGO:2001243400.042
dna templated transcription elongationGO:0006354250.042
negative regulation of catabolic processGO:00098951040.042
oocyte developmentGO:004859910.041
regulation of ubiquitin protein transferase activityGO:0051438280.040
pallium developmentGO:0021543100.040
hindbrain developmentGO:003090230.040
organelle assemblyGO:00709251760.040
positive regulation of cell cycleGO:00457871400.039
response to oxygen containing compoundGO:19017003690.038
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630500.038
positive regulation of programmed cell deathGO:00430682490.038
behaviorGO:00076101120.037
Fly
protein k63 linked ubiquitinationGO:0070534310.037
positive regulation of proteolysisGO:00458621420.037
Fly
locomotory behaviorGO:000762610.037
tube developmentGO:00352951250.036
positive regulation of meiotic cell cycleGO:005144620.035
cellular response to oxygen levelsGO:0071453550.035
regulation of autophagyGO:0010506520.035
agingGO:0007568660.035
response to hypoxiaGO:0001666960.034
cellular protein complex assemblyGO:00436231880.034
response to cytokineGO:00340972320.033
retrograde transport endosome to golgiGO:0042147450.033
cellular response to hypoxiaGO:0071456510.032
response to light stimulusGO:0009416870.032
long term memoryGO:000761620.032
Fly
negative regulation of protein metabolic processGO:00512483910.032
peptidyl serine modificationGO:00182091060.032
neurogenesisGO:00220081690.032
Fly
regulation of translationGO:0006417890.031
regulation of cellular response to oxidative stressGO:1900407260.031
er associated ubiquitin dependent protein catabolic processGO:0030433310.031
chemical homeostasisGO:00488783060.031
central nervous system developmentGO:00074171230.031
positive regulation of cellular component biogenesisGO:00440891580.030
protein targetingGO:00066051870.030
signal transduction in response to dna damageGO:0042770570.030
positive regulation of proteolysis involved in cellular protein catabolic processGO:1903052350.030
Fly
meiosis iGO:000712740.029
microtubule based processGO:00070172100.029
primary neural tube formationGO:001402030.029
organelle fissionGO:00482851490.029
symbiosis encompassing mutualism through parasitismGO:00444031560.029
cell divisionGO:00513011680.029
regulation of transferase activityGO:00513383550.029
nuclear transportGO:00511691790.029
anatomical structure homeostasisGO:00602491000.029
negative regulation of hydrolase activityGO:00513461820.028
response to topologically incorrect proteinGO:0035966290.028
regulation of dna metabolic processGO:00510521530.028
regulation of response to nutrient levelsGO:0032107220.028
vesicle mediated transportGO:00161923710.027
Mouse
peptide transportGO:0015833740.027
embryonic cranial skeleton morphogenesisGO:004870160.027
ribonucleoprotein complex biogenesisGO:00226131160.027
vacuole organizationGO:0007033440.027
response to oxidative stressGO:00069791210.027
cation homeostasisGO:00550801890.027
histone h4 k5 acetylationGO:0043981150.026
ion transmembrane transportGO:00342203380.026
regulation of protein import into nucleusGO:0042306780.026
response to uvGO:0009411730.026
negative regulation of cell growthGO:0030308830.026
cellular response to endogenous stimulusGO:00714953360.025
regulation of protein processingGO:00706131500.025
dna damage checkpointGO:0000077680.025
regulation of cytoskeleton organizationGO:00514931770.025
intrinsic apoptotic signaling pathway by p53 class mediatorGO:0072332370.025
cellular response to radiationGO:0071478650.024
positive regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032436300.024
regenerationGO:003109940.024
protein localization to organelleGO:00333652800.024
negative regulation of nervous system developmentGO:0051961280.024
regulation of oxidative stress induced intrinsic apoptotic signaling pathwayGO:1902175160.024
hippocampus developmentGO:002176610.024
histone ubiquitinationGO:0016574310.024
transcription elongation from rna polymerase ii promoterGO:0006368180.024
regulation of dna repairGO:0006282470.023
dna replicationGO:00062601160.023
muscle contractionGO:0006936730.023
neurological system processGO:00508771630.023
Fly
metal ion transportGO:00300012720.023
embryo developmentGO:00097901230.023
positive regulation of cell cycle processGO:00900681060.023
neuron developmentGO:00486661130.022
Fly
negative regulation of phosphorylationGO:00423261740.022
intrinsic apoptotic signaling pathway in response to oxidative stressGO:0008631210.022
response to lipidGO:00339932060.022
glycosylationGO:0070085710.022
dna integrity checkpointGO:0031570710.022
cellular homeostasisGO:00197251960.022
neuromuscular junction developmentGO:000752830.022
regulation of epithelial cell proliferationGO:00506781130.021
response to extracellular stimulusGO:0009991850.021
regulation of establishment of protein localizationGO:00702012420.021
central nervous system projection neuron axonogenesisGO:002195230.021
regulation of autophagic vacuole assemblyGO:200078560.021
regulation of chromosome organizationGO:00330441030.021
response to oxygen levelsGO:00704821000.021
positive regulation of catabolic processGO:00098963100.021
Fly
regulation of bindingGO:00510981110.021
transcription factor import into nucleusGO:0042991400.021
er nucleus signaling pathwayGO:0006984230.021
limbic system developmentGO:002176130.020
establishment of tissue polarityGO:000716430.020
protein localization to nucleusGO:00345041360.020
lipid localizationGO:00108761060.020
response to gamma radiationGO:0010332140.020
anatomical structure formation involved in morphogenesisGO:00486462840.019
muscle system processGO:0003012810.019
regulation of macroautophagyGO:0016241190.019
mitochondrion organizationGO:00070051560.019
protein localization to membraneGO:00726571600.019
positive regulation of developmental processGO:00510943140.019
chordate embryonic developmentGO:0043009340.019
negative regulation of epidermal growth factor receptor signaling pathwayGO:0042059110.019
regulation of ion transmembrane transportGO:00347651320.019
regulation of gene expression epigeneticGO:0040029730.019
cellular metal ion homeostasisGO:00068751460.019
reproductive system developmentGO:0061458560.018
Mouse
positive regulation of cell differentiationGO:00455972110.018
male gamete generationGO:0048232220.018
positive regulation of cellular component organizationGO:00511303760.018
negative regulation of growthGO:0045926970.018
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.018
positive regulation of cell deathGO:00109422630.018
regulation of cysteine type endopeptidase activityGO:20001161270.018
cellular component morphogenesisGO:00329893140.018
Fly
cell type specific apoptotic processGO:00972851250.018
regulation of membrane potentialGO:0042391950.017
negative regulation of transportGO:00510511760.017
cellular response to decreased oxygen levelsGO:0036294510.017
interspecies interaction between organismsGO:00444191560.017
protein k63 linked deubiquitinationGO:0070536210.017
regulation of organelle assemblyGO:1902115400.017
nuclear divisionGO:00002801280.017
tube morphogenesisGO:0035239950.017
immune system developmentGO:00025201950.017
regulation of response to external stimulusGO:00321012220.017
cellular response to oxygen containing compoundGO:19017012760.017
stem cell developmentGO:0048864690.017
protein homooligomerizationGO:00512601000.017
negative regulation of transferase activityGO:00513481240.017
protein modification by small protein removalGO:0070646920.016
regulation of peptide transportGO:0090087620.016
peptidyl tyrosine modificationGO:00182121700.016
striated muscle contractionGO:0006941520.016
organelle localizationGO:0051640840.016
brain morphogenesisGO:004885410.016
negative regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043154460.016
extrinsic apoptotic signaling pathwayGO:00971911190.016
positive regulation of peptidase activityGO:0010952880.016
translationGO:00064121320.016
spermatid differentiationGO:004851540.016
response to organic cyclic compoundGO:00140702040.015
cytokinesisGO:0000910960.015
endocytosisGO:00068971590.015
Mouse
golgi vesicle transportGO:0048193800.015
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.015
positive regulation of canonical wnt signaling pathwayGO:0090263330.015
cellular response to starvationGO:0009267580.015
positive regulation of response to dna damage stimulusGO:2001022430.015
negative regulation of transcription elongation from rna polymerase ii promoterGO:003424440.015
response to salt stressGO:000965130.015
cellular response to ionizing radiationGO:0071479320.015
positive regulation of protein catabolic processGO:0045732750.015
Fly
regulation of epidermal growth factor receptor signaling pathwayGO:0042058270.015
negative regulation of response to dna damage stimulusGO:2001021330.015
urogenital system developmentGO:0001655650.015
Mouse
histone h4 k8 acetylationGO:0043982150.015
regulation of proteolysis involved in cellular protein catabolic processGO:1903050910.015
Fly
spermatid developmentGO:000728640.014
protein glycosylationGO:0006486620.014
protein k48 linked deubiquitinationGO:0071108190.014
monocarboxylic acid metabolic processGO:00327871850.014
cellular response to nitrogen compoundGO:19016991440.014
regulation of locomotionGO:00400123290.014
protein dephosphorylationGO:0006470810.014
embryonic organ developmentGO:0048568360.014
positive regulation of cell developmentGO:0010720920.014
cellular chemical homeostasisGO:00550821800.014
endomembrane system organizationGO:00102561960.014
maintenance of locationGO:00512351120.014
dephosphorylationGO:00163112090.014
regulation of neuron apoptotic processGO:0043523350.014
immune responseGO:00069553070.014
negative regulation of protein transportGO:0051224750.014
reproductionGO:0000003630.014
Mouse
mitotic nuclear divisionGO:00070671190.014
embryo development ending in birth or egg hatchingGO:0009792340.014
negative regulation of cell morphogenesis involved in differentiationGO:0010771240.013
skin developmentGO:0043588760.013
positive regulation of nf kappab transcription factor activityGO:0051092810.013
cellular response to topologically incorrect proteinGO:0035967190.013
negative regulation of developmental processGO:00510932470.013
regulation of transporter activityGO:0032409820.013
developmental programmed cell deathGO:001062330.013
signal transduction by p53 class mediatorGO:0072331720.013
single organism reproductive processGO:0044702980.013
Mouse
negative regulation of kinase activityGO:00336731060.013
positive regulation of cellular protein catabolic processGO:1903364370.013
Fly
establishment of monopolar cell polarityGO:006116210.013
regulation of cell divisionGO:00513021160.013
multi organism reproductive processGO:0044703540.013
Mouse
regulation of erbb signaling pathwayGO:1901184270.013
developmental cell growthGO:0048588180.012
neuron apoptotic processGO:0051402390.012
divalent metal ion transportGO:00708381520.012
developmental growthGO:0048589480.012
Mouse
nuclear migrationGO:000709710.012
vasculature developmentGO:00019441810.012
meiotic cell cycle processGO:190304680.012
chemotaxisGO:00069351570.012
negative regulation of organelle organizationGO:00106391260.012
angiogenesisGO:00015251470.012
regulation of protein localizationGO:00328802960.012
neuron deathGO:0070997650.012
tripartite regional subdivisionGO:000735120.012
embryonic organ morphogenesisGO:0048562240.012
regulation of epithelial cell migrationGO:0010632930.012
intracellular protein transportGO:00068862700.011
response to dietary excessGO:000202120.011
cell morphogenesis involved in neuron differentiationGO:0048667440.011
Fly
positive regulation of cellular component movementGO:00512721810.011
positive regulation of cell growthGO:0030307480.011
reproductive processGO:00224141060.011
Mouse
ion homeostasisGO:00508012300.011
organic acid catabolic processGO:0016054710.011
digestive tract morphogenesisGO:0048546560.011
regulation of neuron deathGO:1901214560.011
sleepGO:003043120.011
regulation of microtubule cytoskeleton organizationGO:0070507610.011
blood vessel developmentGO:00015681720.011
establishment of protein localization to organelleGO:00725941720.011
negative regulation of cell differentiationGO:00455961710.011
peptidyl tyrosine phosphorylationGO:00181081700.011
outflow tract septum morphogenesisGO:000314840.011
regulation of cell morphogenesis involved in differentiationGO:0010769830.011
negative regulation of protein modification processGO:00314002000.011
system processGO:00030083490.010
Fly
positive regulation of cellular amino acid metabolic processGO:004576430.010
sequestering of metal ionGO:0051238240.010
regulation of histone acetylationGO:0035065190.010
regulation of protein serine threonine kinase activityGO:00719001790.010
positive regulation of phosphorylationGO:00423273940.010
regulation of transcription factor import into nucleusGO:0042990390.010
cytoplasmic transportGO:00164823790.010
negative regulation of cellular amine metabolic processGO:003323930.010
negative regulation of protein catabolic processGO:0042177590.010
multicellular organism reproductionGO:0032504420.010
Mouse

UBE3A disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
neurodegenerative diseaseDOID:12891020.084
nervous system diseaseDOID:8634310.084
central nervous system diseaseDOID:3311860.084
musculoskeletal system diseaseDOID:172230.019
organ system cancerDOID:00506861640.018
cancerDOID:1621670.018
disease of cellular proliferationDOID:145661740.018
muscle tissue diseaseDOID:661130.010
muscular diseaseDOID:00800001140.010
myopathyDOID:4231040.010
chromosomal diseaseDOID:0080014160.000
angelman syndromeDOID:193230.000