Homo sapiens

81 known processes

TOP2B

topoisomerase (DNA) II beta 180kDa

(Aliases: TOPIIB,top2beta)

TOP2B biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
microtubule based processGO:00070172100.815
Fly
ribonucleoside monophosphate metabolic processGO:00091611870.683
purine nucleoside triphosphate metabolic processGO:00091444120.595
post embryonic developmentGO:000979120.578
Worm
macromolecule methylationGO:0043414970.510
ribonucleoside monophosphate catabolic processGO:00091581580.508
chromatin modificationGO:00165682980.464
Yeast
histone lysine methylationGO:0034968500.418
histone methylationGO:0016571600.414
purine nucleoside triphosphate catabolic processGO:00091463920.388
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.374
mitotic cell cycleGO:00002783260.372
Yeast Fly
nucleoside monophosphate metabolic processGO:00091231910.339
protein oligomerizationGO:00512591730.336
chromatin organizationGO:00063253510.333
Yeast
organophosphate catabolic processGO:00464344300.311
nucleoside triphosphate metabolic processGO:00091414220.295
purine ribonucleoside monophosphate catabolic processGO:00091691580.282
cell divisionGO:00513011680.275
neuromuscular junction developmentGO:000752830.273
vesicle mediated transportGO:00161923710.263
Worm
female gamete generationGO:000729220.263
neuroblast proliferationGO:000740540.262
purine ribonucleoside metabolic processGO:00461284370.260
apoptotic signaling pathwayGO:00971902680.243
locomotory behaviorGO:000762610.241
purine containing compound catabolic processGO:00725234110.237
ribonucleoside catabolic processGO:00424544060.233
cellular ketone metabolic processGO:0042180800.229
ribonucleoside triphosphate catabolic processGO:00092033910.225
purine ribonucleoside monophosphate metabolic processGO:00091671860.216
positive regulation of developmental processGO:00510943140.215
protein modification by small protein conjugationGO:00324463420.213
nucleoside monophosphate catabolic processGO:00091251590.210
dna repairGO:00062811980.208
regulation of cellular component biogenesisGO:00440872810.200
cellular macromolecular complex assemblyGO:00346223240.196
chemotaxisGO:00069351570.193
Zebrafish
cellular response to dna damage stimulusGO:00069743790.191
Human Fly
oocyte developmentGO:004859910.189
gene silencingGO:0016458490.189
Worm Fly
interspecies interaction between organismsGO:00444191560.188
Human
cellular component disassemblyGO:0022411920.188
Human
microtubule cytoskeleton organizationGO:00002261760.181
Fly
purine nucleoside monophosphate catabolic processGO:00091281580.178
nucleoside catabolic processGO:00091644080.167
protein methylationGO:0006479740.160
generation of neuronsGO:00486991520.156
Zebrafish Mouse
negative regulation of cellular component organizationGO:00511292350.156
nuclear divisionGO:00002801280.153
Yeast Fly
mitotic spindle organizationGO:0007052270.151
Fly
protein alkylationGO:0008213740.151
double strand break repairGO:00063021010.146
response to oxygen containing compoundGO:19017003690.146
cell part morphogenesisGO:00329901370.145
Zebrafish Mouse
response to abiotic stimulusGO:00096283360.141
methylationGO:00322591060.141
oocyte differentiationGO:000999420.139
embryo developmentGO:00097901230.138
Worm
embryo development ending in birth or egg hatchingGO:0009792340.137
Worm
multicellular organismal agingGO:001025930.136
spermatid developmentGO:000728640.135
purine nucleoside monophosphate metabolic processGO:00091261860.135
spindle organizationGO:0007051530.135
Fly
cellular component morphogenesisGO:00329893140.134
Zebrafish Mouse
mrna metabolic processGO:00160711750.131
oogenesisGO:004847720.127
regulation of dna metabolic processGO:00510521530.126
Human Yeast
reproductive processGO:00224141060.125
cellular homeostasisGO:00197251960.120
embryonic epithelial tube formationGO:000183840.119
regulation of gene expression epigeneticGO:0040029730.116
Worm Fly
viral life cycleGO:00190581320.113
Human
reproductive system developmentGO:0061458560.112
determination of adult lifespanGO:000834020.111
mrna processingGO:00063971330.110
cellular amino acid metabolic processGO:00065201160.103
purine ribonucleoside triphosphate metabolic processGO:00092054110.102
neurogenesisGO:00220081690.102
Zebrafish Mouse
purine nucleoside catabolic processGO:00061523980.101
glycosyl compound catabolic processGO:19016584130.096
cell morphogenesisGO:00009022960.093
Zebrafish Mouse
cell morphogenesis involved in differentiationGO:00009041440.092
Zebrafish Mouse
regulation of viral processGO:00507921030.092
Human
nucleoside triphosphate catabolic processGO:00091433940.091
negative regulation of multicellular organismal processGO:00512413170.087
cellular response to oxygen containing compoundGO:19017012760.085
nucleosome positioningGO:001658430.082
regulation of symbiosis encompassing mutualism through parasitismGO:00439031090.081
Human
spermatid differentiationGO:004851540.081
centrosome organizationGO:0051297580.081
cell morphogenesis involved in neuron differentiationGO:0048667440.080
Zebrafish Mouse
regulation of protein complex assemblyGO:00432541470.079
sensory perceptionGO:00076001030.078
nucleoside phosphate catabolic processGO:19012924120.077
cell projection morphogenesisGO:00488581290.076
Zebrafish Mouse
purine nucleotide catabolic processGO:00061954050.076
organelle fissionGO:00482851490.075
Yeast Fly
defense responseGO:00069523150.074
regulation of cytoskeleton organizationGO:00514931770.072
embryonic morphogenesisGO:0048598850.071
ribonucleoside triphosphate metabolic processGO:00091994120.070
cytokinesisGO:0000910960.069
protein catabolic processGO:00301633250.069
symbiosis encompassing mutualism through parasitismGO:00444031560.068
Human
response to biotic stimulusGO:00096072760.066
negative regulation of apoptotic processGO:00430663160.066
purine ribonucleoside triphosphate catabolic processGO:00092073910.066
taxisGO:00423301570.064
Zebrafish
associative learningGO:000830610.063
developmental process involved in reproductionGO:0003006660.063
viral processGO:00160321460.062
Human
regulation of cell morphogenesisGO:00226041530.060
carbohydrate metabolic processGO:00059752070.060
mitotic cell cycle processGO:19030472860.059
Yeast Fly
rna interferenceGO:001624640.058
Worm
immune responseGO:00069553070.058
chromatin silencingGO:0006342120.056
Fly
organelle assemblyGO:00709251760.055
dendrite developmentGO:0016358240.055
neuron developmentGO:00486661130.054
Zebrafish Mouse
ribonucleotide catabolic processGO:00092614050.054
mitotic nuclear divisionGO:00070671190.054
Fly
response to growth factorGO:00708482050.053
histone exchangeGO:004348630.052
cellular protein complex assemblyGO:00436231880.052
regulation of establishment of protein localizationGO:00702012420.051
growthGO:00400072020.050
reproductive structure developmentGO:0048608550.050
protein complex disassemblyGO:0043241520.050
hindbrain developmentGO:003090230.050
agingGO:0007568660.049
nervous system developmentGO:00073992930.049
Zebrafish Mouse
rna splicingGO:00083801310.048
response to organic cyclic compoundGO:00140702040.047
regulation of cellular ketone metabolic processGO:0010565500.047
protein homooligomerizationGO:00512601000.047
purine ribonucleoside catabolic processGO:00461303980.046
cell developmentGO:00484683280.046
Zebrafish Mouse
intracellular steroid hormone receptor signaling pathwayGO:0030518610.046
multi organism metabolic processGO:0044033410.046
Human
covalent chromatin modificationGO:00165692540.046
mitotic sister chromatid segregationGO:0000070530.045
Fly
nucleotide catabolic processGO:00091664080.044
peptidyl lysine methylationGO:0018022370.044
negative regulation of catalytic activityGO:00430863350.043
positive regulation of cellular amine metabolic processGO:003324070.043
ribonucleoprotein complex assemblyGO:0022618780.042
negative regulation of nervous system developmentGO:0051961280.042
morphogenesis of embryonic epitheliumGO:001633140.042
system processGO:00030083490.042
cellular response to endogenous stimulusGO:00714953360.041
cellular response to growth factor stimulusGO:00713631970.040
neuron differentiationGO:00301821380.040
Zebrafish Mouse
posttranscriptional gene silencingGO:0016441250.039
Worm
chromatin assembly or disassemblyGO:0006333780.039
Yeast
developmental growthGO:0048589480.038
ribonucleoprotein complex subunit organizationGO:0071826810.038
positive regulation of apoptotic processGO:00430652460.037
Human
anatomical structure formation involved in morphogenesisGO:00486462840.037
Zebrafish
epithelium developmentGO:00604292270.037
macromolecular complex disassemblyGO:0032984600.037
positive regulation of cellular component organizationGO:00511303760.036
cellular response to organic cyclic compoundGO:00714071270.036
response to nutrient levelsGO:0031667810.036
positive regulation of cellular amino acid metabolic processGO:004576430.035
circulatory system developmentGO:00723592620.035
negative regulation of cell deathGO:00605483450.035
single organism reproductive processGO:0044702980.034
positive regulation of transportGO:00510503360.034
regulation of intrinsic apoptotic signaling pathwayGO:2001242720.034
regulation of cellular response to stressGO:00801352440.034
negative regulation of gene expression epigeneticGO:0045814190.033
Fly
receptor mediated endocytosisGO:0006898840.033
Worm
amine metabolic processGO:0009308440.033
ameboidal type cell migrationGO:00016671350.033
primary neural tube formationGO:001402030.033
regulation of neural precursor cell proliferationGO:200017740.033
head developmentGO:00603221080.033
Mouse
enzyme linked receptor protein signaling pathwayGO:00071673030.032
glucose homeostasisGO:0042593310.032
atp catabolic processGO:00062001570.032
atp dependent chromatin remodelingGO:0043044250.032
positive regulation of wnt signaling pathwayGO:0030177540.032
chromosome segregationGO:00070591140.032
Human Fly
sex differentiationGO:0007548450.031
response to extracellular stimulusGO:0009991850.031
reproductionGO:0000003630.031
Yeast Worm
nucleosome organizationGO:0034728660.031
epithelial cell migrationGO:00106311190.030
regulation of cell differentiationGO:00455953930.030
regulation of locomotionGO:00400123290.030
purine ribonucleotide catabolic processGO:00091544040.030
rna processingGO:00063962550.030
intrinsic apoptotic signaling pathwayGO:00971931270.029
positive regulation of cellular component biogenesisGO:00440891580.029
negative regulation of phosphate metabolic processGO:00459362670.029
neuron projection developmentGO:00311751060.029
Zebrafish Mouse
negative regulation of phosphorus metabolic processGO:00105632670.029
response to hormoneGO:00097251750.028
protein polymerizationGO:0051258710.028
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.028
negative regulation of programmed cell deathGO:00430693210.028
cellular response to nitrogen compoundGO:19016991440.028
secretionGO:00469032540.027
memoryGO:000761330.027
negative regulation of cell developmentGO:0010721480.027
chromatin remodelingGO:0006338550.027
Yeast
posttranscriptional regulation of gene expressionGO:00106082130.027
Worm
cardiovascular system developmentGO:00723582620.027
development of primary sexual characteristicsGO:0045137350.027
gonad developmentGO:0008406340.027
viral transcriptionGO:0019083350.027
behaviorGO:00076101120.025
intracellular receptor signaling pathwayGO:00305221040.025
cell adhesionGO:00071553250.025
cellular response to lipidGO:00713961270.025
multicellular organismal reproductive processGO:0048609400.025
regulation of gene silencingGO:0060968240.025
regulation of dna recombinationGO:0000018230.024
Yeast
biological adhesionGO:00226103310.024
regulation of cell developmentGO:00602841610.024
regulation of cell cycle processGO:00105642660.024
Yeast Fly
long chain fatty acid catabolic processGO:004275830.024
negative regulation of organelle organizationGO:00106391260.024
brain developmentGO:0007420970.024
Mouse
response to lipidGO:00339932060.023
maintenance of locationGO:00512351120.023
regulation of cellular amine metabolic processGO:0033238110.023
protein targetingGO:00066051870.023
response to radiationGO:00093141510.023
neuron projection morphogenesisGO:0048812500.023
Zebrafish Mouse
mitotic cytokinesisGO:0000281190.022
cellular amine metabolic processGO:0044106410.022
regulation of viral transcriptionGO:0046782340.022
meiotic chromosome segregationGO:004513240.022
central nervous system developmentGO:00074171230.022
Mouse
multi organism cellular processGO:00447641560.022
Human
regulation of wnt signaling pathwayGO:00301111230.022
sister chromatid segregationGO:0000819540.022
Fly
cell projection organizationGO:00300302520.021
Zebrafish Mouse
single organism carbohydrate metabolic processGO:00447231930.021
tissue migrationGO:00901301190.021
regulation of protein modification by small protein conjugation or removalGO:19033201070.021
cellular macromolecule catabolic processGO:00442653800.021
regulation of multi organism processGO:00439001570.021
Human
protein dna complex subunit organizationGO:0071824800.021
epithelium migrationGO:00901321190.021
regulation of neuron projection developmentGO:0010975570.020
immune system developmentGO:00025201950.020
viral gene expressionGO:0019080350.020
establishment or maintenance of cytoskeleton polarityGO:003095230.020
response to other organismGO:00517072610.020
regulation of apoptotic signaling pathwayGO:20012331750.020
negative regulation of cellular protein metabolic processGO:00322693530.020
neural tube formationGO:000184130.020
regulation of sequence specific dna binding transcription factor activityGO:00510902110.020
regulation of dna repairGO:0006282470.020
wnt signaling pathwayGO:00160551560.020
proteolysis involved in cellular protein catabolic processGO:00516032440.020
regulation of cell migrationGO:00303342890.019
regulation of cellular component movementGO:00512703340.019
regulation of response to dna damage stimulusGO:2001020940.019
response to alcoholGO:0097305640.019
protein modification by small protein removalGO:0070646920.019
negative regulation of growthGO:0045926970.019
modification by host of symbiont morphology or physiologyGO:0051851260.018
cellular carbohydrate metabolic processGO:0044262840.018
response to starvationGO:0042594590.018
endocytosisGO:00068971590.018
Worm
rna splicing via transesterification reactions with bulged adenosine as nucleophileGO:0000377890.018
meiotic nuclear divisionGO:0007126100.018
Yeast
cellular protein catabolic processGO:00442572610.018
regulation of cellular amino acid metabolic processGO:000652160.018
cellular response to external stimulusGO:00714961110.018
negative regulation of intracellular signal transductionGO:19025321830.017
cytoplasmic transportGO:00164823790.017
actin filament based processGO:00300292240.017
short term memoryGO:000761410.017
positive regulation of intracellular transportGO:00323881040.017
regulation of nervous system developmentGO:0051960880.017
regulation of anatomical structure morphogenesisGO:00226032860.017
negative regulation of apoptotic signaling pathwayGO:2001234970.017
histone modificationGO:00165702510.017
multicellular organism reproductionGO:0032504420.016
regulation of meiotic cell cycleGO:005144540.016
response to transforming growth factor betaGO:0071559940.016
positive regulation of dna metabolic processGO:0051054730.016
Human
regulation of nucleocytoplasmic transportGO:0046822980.016
regulation of cell motilityGO:20001452990.016
cell cycle checkpointGO:00000751170.016
Yeast Fly
vasculature developmentGO:00019441810.016
cerebellum developmentGO:002154920.015
dna conformation changeGO:00711031130.015
cyclic purine nucleotide metabolic processGO:0052652600.015
chordate embryonic developmentGO:0043009340.015
neural tube patterningGO:002153220.015
response to light stimulusGO:0009416870.015
regulation of double strand break repairGO:2000779220.015
ncrna metabolic processGO:00346601080.015
negative regulation of developmental processGO:00510932470.015
positive regulation of proteolysisGO:00458621420.015
negative regulation of transferase activityGO:00513481240.015
response to nitrogen compoundGO:19016981840.015
regulation of chromatin modificationGO:1903308510.014
ribonucleoprotein complex biogenesisGO:00226131160.014
response to oxygen levelsGO:00704821000.014
regulation of mitotic cell cycleGO:00073461890.014
Yeast Fly
mismatch repairGO:0006298150.014
ossificationGO:00015031210.014
regulation of homeostatic processGO:00328441210.014
regulation of protein localizationGO:00328802960.014
rna splicing via transesterification reactionsGO:0000375900.014
long term memoryGO:000761620.013
sleepGO:003043120.013
neurological system processGO:00508771630.013
organelle localizationGO:0051640840.013
Fly
transforming growth factor beta receptor signaling pathwayGO:0007179760.013
response to hypoxiaGO:0001666960.013
cellular response to hormone stimulusGO:00328701250.013
nitrogen compound transportGO:00717051910.013
mitotic spindle elongationGO:000002240.012
regulation of epithelial cell migrationGO:0010632930.012
axon developmentGO:0061564340.012
Zebrafish Mouse
regulation of glucokinase activityGO:003313120.012
hematopoietic or lymphoid organ developmentGO:00485341860.012
rostrocaudal neural tube patterningGO:002190310.012
chemical homeostasisGO:00488783060.012
mrna splicing via spliceosomeGO:0000398890.012
regulation of cell cycleGO:00517263930.012
Yeast Fly
single organism cellular localizationGO:19025803320.012
nuclear importGO:00511701060.012
regulation of neuroblast proliferationGO:190269230.012
modification of morphology or physiology of other organismGO:0035821430.012
negative regulation of phosphorylationGO:00423261740.011
regulation of mitotic cell cycle phase transitionGO:19019901180.011
Yeast Fly
multi organism reproductive processGO:0044703540.011
positive regulation of dendrite morphogenesisGO:005077530.011
regulation of growthGO:00400081650.011
nucleocytoplasmic transportGO:00069131760.011
peptidyl lysine trimethylationGO:0018023100.011
positive regulation of programmed cell deathGO:00430682490.011
Human
free ubiquitin chain polymerizationGO:001099420.011
microtubule organizing center organizationGO:0031023620.011
neural tube closureGO:000184330.011
cellular response to extracellular stimulusGO:0031668720.011
tube closureGO:006060630.011
innate immune responseGO:00450871780.011
regulation of cysteine type endopeptidase activityGO:20001161270.011
regulation of neuron differentiationGO:0045664700.011
organ morphogenesisGO:00098871470.011
Zebrafish
embryonic placenta developmentGO:000189210.011
synaptic transmissionGO:0007268610.011
regionalizationGO:0003002290.011
positive regulation of cell deathGO:00109422630.011
Human
dna recombinationGO:0006310770.011
Yeast
dna templated transcription terminationGO:000635330.011
telomere organizationGO:0032200330.010
detection of mechanical stimulus involved in sensory perceptionGO:005097410.010
response to external biotic stimulusGO:00432072610.010
neural tube developmentGO:002191590.010
central nervous system neuron axonogenesisGO:002195530.010
negative regulation of small gtpase mediated signal transductionGO:0051058120.010
photoreceptor cell differentiationGO:004653020.010
cell cycle phase transitionGO:00447701730.010
Yeast Fly
defense response to other organismGO:00985421290.010
response to decreased oxygen levelsGO:0036293960.010

TOP2B disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:145661740.021
cancerDOID:1621670.018
organ system cancerDOID:00506861640.018
disease of metabolismDOID:00146672950.015