Homo sapiens

153 known processes

GCH1

GTP cyclohydrolase 1

(Aliases: DYT14,HPABH4B,GTPCH1,GCH,GTP-CH-1,DYT5,DYT5a)

GCH1 biological process predictions


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Biological processGO term IDProcess sizeProbabilityFunc Analog Org
nucleoside triphosphate metabolic processGO:00091414220.523
nucleoside catabolic processGO:00091644080.523
ribonucleoside triphosphate metabolic processGO:00091994120.381
purine ribonucleoside metabolic processGO:00461284370.327
nucleotide catabolic processGO:00091664080.312
purine ribonucleoside catabolic processGO:00461303980.312
purine nucleoside monophosphate catabolic processGO:00091281580.311
purine ribonucleotide catabolic processGO:00091544040.308
negative regulation of cell deathGO:00605483450.228
purine nucleoside catabolic processGO:00061523980.228
ribonucleotide catabolic processGO:00092614050.226
purine ribonucleoside triphosphate metabolic processGO:00092054110.221
purine ribonucleoside triphosphate catabolic processGO:00092073910.219
cellular amino acid metabolic processGO:00065201160.206
purine containing compound catabolic processGO:00725234110.202
purine ribonucleoside monophosphate catabolic processGO:00091691580.199
ribonucleoside monophosphate catabolic processGO:00091581580.196
response to cytokineGO:00340972320.187
determination of adult lifespanGO:000834020.186
atp catabolic processGO:00062001570.171
nucleoside triphosphate catabolic processGO:00091433940.164
multicellular organismal agingGO:001025930.154
ribonucleoside triphosphate catabolic processGO:00092033910.144
nucleoside phosphate catabolic processGO:19012924120.141
immune effector processGO:00022521590.134
nucleoside monophosphate catabolic processGO:00091251590.134
nucleoside monophosphate metabolic processGO:00091231910.130
ribonucleoside monophosphate metabolic processGO:00091611870.128
purine nucleoside triphosphate catabolic processGO:00091463920.125
response to abiotic stimulusGO:00096283360.114
atp metabolic processGO:00460341760.110
post embryonic developmentGO:000979120.106
negative regulation of apoptotic processGO:00430663160.103
organophosphate catabolic processGO:00464344300.100
glycosyl compound catabolic processGO:19016584130.098
mitochondrion organizationGO:00070051560.097
cellular amine metabolic processGO:0044106410.097
ribonucleoside catabolic processGO:00424544060.093
carbohydrate derivative biosynthetic processGO:19011372070.091
purine nucleoside triphosphate metabolic processGO:00091444120.091
purine nucleotide catabolic processGO:00061954050.086
nucleotide biosynthetic processGO:00091651090.083
intrinsic apoptotic signaling pathwayGO:00971931270.083
negative regulation of protein metabolic processGO:00512483910.083
purine ribonucleoside monophosphate metabolic processGO:00091671860.082
regulation of transferase activityGO:00513383550.081
cell type specific apoptotic processGO:00972851250.080
immune responseGO:00069553070.079
cellular response to dna damage stimulusGO:00069743790.077
cellular macromolecular complex assemblyGO:00346223240.076
cell projection organizationGO:00300302520.072
cofactor metabolic processGO:0051186870.072
organonitrogen compound biosynthetic processGO:19015662000.069
purine nucleoside monophosphate metabolic processGO:00091261860.068
reactive nitrogen species metabolic processGO:200105730.066
hematopoietic or lymphoid organ developmentGO:00485341860.066
response to biotic stimulusGO:00096072760.063
response to external biotic stimulusGO:00432072610.061
nucleoside phosphate biosynthetic processGO:19012931090.060
organophosphate biosynthetic processGO:00904071630.058
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630500.057
regulation of cellular response to stressGO:00801352440.057
negative regulation of programmed cell deathGO:00430693210.057
protein catabolic processGO:00301633250.056
regulation of multi organism processGO:00439001570.055
defense response to other organismGO:00985421290.055
cellular response to oxygen containing compoundGO:19017012760.055
response to virusGO:00096151260.054
regulation of reactive oxygen species metabolic processGO:2000377410.054
regulation of reactive oxygen species biosynthetic processGO:190342630.053
regulation of nucleoside metabolic processGO:00091182090.051
negative regulation of phosphorus metabolic processGO:00105632670.051
negative regulation of catalytic activityGO:00430863350.051
reactive oxygen species biosynthetic processGO:190340940.050
regulation of atpase activityGO:0043462250.050
apoptotic signaling pathwayGO:00971902680.050
alditol phosphate metabolic processGO:005264630.049
cellular macromolecule catabolic processGO:00442653800.049
chemical homeostasisGO:00488783060.048
response to nitrogen compoundGO:19016981840.048
response to oxygen containing compoundGO:19017003690.048
locomotory behaviorGO:000762610.047
amine metabolic processGO:0009308440.047
hemopoiesisGO:00300971800.047
positive regulation of catabolic processGO:00098963100.046
positive regulation of hydrolase activityGO:00513453310.046
cellular modified amino acid metabolic processGO:0006575640.045
reactive oxygen species metabolic processGO:0072593750.045
cell death in response to oxidative stressGO:0036473290.043
regulation of cellular amino acid metabolic processGO:000652160.043
regulation of atp catabolic processGO:1903289250.043
apoptotic mitochondrial changesGO:0008637570.043
cellular component morphogenesisGO:00329893140.042
response to radiationGO:00093141510.042
defense response to virusGO:0051607710.042
epithelium developmentGO:00604292270.041
cell activationGO:00017752130.041
guanosine containing compound metabolic processGO:19010682440.041
protein localization to organelleGO:00333652800.041
carbohydrate metabolic processGO:00059752070.039
response to other organismGO:00517072610.039
positive regulation of cell proliferationGO:00082843010.039
vasodilationGO:004231140.039
protein maturationGO:00516042330.039
regulation of kinase activityGO:00435493140.039
negative regulation of phosphorylationGO:00423261740.038
regulation of nucleotide catabolic processGO:00308112050.037
defense responseGO:00069523150.037
immune system developmentGO:00025201950.037
negative regulation of cellular protein metabolic processGO:00322693530.037
leukocyte differentiationGO:0002521980.037
lipid metabolic processGO:00066293810.037
innate immune responseGO:00450871780.036
regulation of purine nucleotide metabolic processGO:19005422640.035
negative regulation of phosphate metabolic processGO:00459362670.035
ribonucleotide biosynthetic processGO:0009260810.035
regulation of apoptotic signaling pathwayGO:20012331750.034
negative regulation of protein phosphorylationGO:00019331400.033
regulation of nucleotide metabolic processGO:00061402690.033
regulation of ion transportGO:00432691890.033
single organism cellular localizationGO:19025803320.032
positive regulation of immune system processGO:00026842830.032
regulation of cellular component biogenesisGO:00440872810.032
signal transduction by phosphorylationGO:00230142970.032
regulation of cellular ketone metabolic processGO:0010565500.031
endomembrane system organizationGO:00102561960.031
positive regulation of programmed cell deathGO:00430682490.031
protein modification by small protein conjugationGO:00324463420.031
generation of neuronsGO:00486991520.031
negative regulation of protein serine threonine kinase activityGO:0071901570.030
secretionGO:00469032540.030
regulation of immune responseGO:00507762010.029
negative regulation of protein kinase activityGO:0006469980.029
regulation of response to external stimulusGO:00321012220.029
protein oligomerizationGO:00512591730.029
mapk cascadeGO:00001652880.029
regulation of purine nucleotide catabolic processGO:00331212050.029
single organism carbohydrate metabolic processGO:00447231930.029
ion homeostasisGO:00508012300.028
regulation of cellular amine metabolic processGO:0033238110.028
regulation of protein serine threonine kinase activityGO:00719001790.027
ion transmembrane transportGO:00342203380.027
regulation of endopeptidase activityGO:00525481700.027
regulation of response to dna damage stimulusGO:2001020940.027
lymphocyte homeostasisGO:000226040.027
coagulationGO:0050817780.027
divalent inorganic cation transportGO:00725111580.026
regulation of atp metabolic processGO:1903578290.026
regulation of map kinase activityGO:00434051080.026
proteolysis involved in cellular protein catabolic processGO:00516032440.026
neuron differentiationGO:00301821380.026
regulation of i kappab kinase nf kappab signalingGO:00431221620.026
negative regulation of transferase activityGO:00513481240.026
cell morphogenesisGO:00009022960.026
establishment of protein localization to organelleGO:00725941720.025
cell developmentGO:00484683280.025
regulation of cell motilityGO:20001452990.025
response to ionizing radiationGO:0010212650.025
cell part morphogenesisGO:00329901370.025
regulation of mapk cascadeGO:00434082620.024
protein processingGO:00164852260.024
response to organonitrogen compoundGO:00102431560.024
positive regulation of purine nucleotide metabolic processGO:19005442270.024
oxidation reduction processGO:00551143960.024
coenzyme biosynthetic processGO:0009108240.024
neuron projection developmentGO:00311751060.024
alcohol metabolic processGO:00060661140.024
negative regulation of intracellular signal transductionGO:19025321830.024
secretion by cellGO:00329402260.024
mitotic cell cycleGO:00002783260.024
regulation of protein kinase activityGO:00458592890.024
cellular ketone metabolic processGO:0042180800.024
nervous system developmentGO:00073992930.023
cytoplasmic transportGO:00164823790.023
regulation of protein maturationGO:19033171500.023
cellular response to lipidGO:00713961270.023
regulation of cell developmentGO:00602841610.023
regulation of cytokine productionGO:00018172320.023
cellular protein complex assemblyGO:00436231880.023
regulation of intrinsic apoptotic signaling pathwayGO:2001242720.023
protein targetingGO:00066051870.023
neurogenesisGO:00220081690.023
sulfur compound metabolic processGO:00067901010.022
cytokine productionGO:00018162470.022
positive regulation of reactive oxygen species biosynthetic processGO:190342820.022
purine ribonucleotide biosynthetic processGO:0009152790.022
regulation of protein processingGO:00706131500.022
positive regulation of cellular amine metabolic processGO:003324070.022
response to oxidative stressGO:00069791210.022
negative regulation of apoptotic signaling pathwayGO:2001234970.022
purine nucleotide biosynthetic processGO:0006164840.022
regulation of cell differentiationGO:00455953930.022
exocytosisGO:0006887710.021
negative regulation of protein processingGO:00109551420.021
regulation of dna metabolic processGO:00510521530.021
blood coagulationGO:0007596760.021
positive regulation of cell differentiationGO:00455972110.021
regulation of anatomical structure sizeGO:00900661010.021
leukocyte mediated cytotoxicityGO:0001909270.021
coenzyme metabolic processGO:0006732650.021
positive regulation of cell deathGO:00109422630.021
ribose phosphate biosynthetic processGO:0046390820.021
intrinsic apoptotic signaling pathway in response to oxidative stressGO:0008631210.020
regulation of cell cycleGO:00517263930.020
negative regulation of cell cycleGO:00457861930.020
response to metal ionGO:0010038840.020
negative regulation of protein modification processGO:00314002000.020
positive regulation of reactive oxygen species metabolic processGO:2000379240.020
cofactor biosynthetic processGO:0051188310.020
dephosphorylationGO:00163112090.020
peptidyl tyrosine modificationGO:00182121700.020
mitotic cell cycle processGO:19030472860.020
positive regulation of response to dna damage stimulusGO:2001022430.020
negative regulation of proteolysisGO:00458611320.020
regulation of immune effector processGO:0002697910.020
negative regulation of t cell apoptotic processGO:007023340.020
positive regulation of nucleoside metabolic processGO:00459791860.020
actin filament based processGO:00300292240.020
nicotinamide nucleotide metabolic processGO:0046496140.019
somatic muscle developmentGO:000752510.019
regulation of cellular component movementGO:00512703340.019
oogenesisGO:004847720.019
regulation of protein catabolic processGO:00421761550.019
hindbrain developmentGO:003090230.019
negative regulation of hydrolase activityGO:00513461820.019
cell fate determinationGO:000170930.019
regulation of blood vessel sizeGO:0050880180.019
gtp metabolic processGO:00460392390.019
detection of stimulusGO:0051606850.019
organic hydroxy compound metabolic processGO:19016151470.019
regulation of anatomical structure morphogenesisGO:00226032860.019
symbiosis encompassing mutualism through parasitismGO:00444031560.019
regulation of neuron apoptotic processGO:0043523350.018
positive regulation of apoptotic signaling pathwayGO:2001235700.018
negative regulation of cell proliferationGO:00082852280.018
positive regulation of cellular catabolic processGO:00313312840.018
anatomical structure formation involved in morphogenesisGO:00486462840.018
plasma membrane organizationGO:00070091150.018
response to tumor necrosis factorGO:0034612760.018
cellular chemical homeostasisGO:00550821800.018
response to axon injuryGO:004867810.018
peptidyl tyrosine phosphorylationGO:00181081700.018
positive regulation of nucleotide metabolic processGO:00459812300.018
generation of precursor metabolites and energyGO:0006091680.018
activation of immune responseGO:00022531140.018
calcium ion transportGO:00068161470.018
memoryGO:000761330.018
regulation of protein localizationGO:00328802960.017
blastoderm segmentationGO:000735020.017
negative regulation of kinase activityGO:00336731060.017
lymphocyte activationGO:00466491330.017
single organism membrane organizationGO:00448022680.017
positive regulation of developmental processGO:00510943140.017
response to organic cyclic compoundGO:00140702040.017
purine containing compound biosynthetic processGO:0072522880.017
divalent metal ion transportGO:00708381520.017
cellular cation homeostasisGO:00300031630.017
regulation of neurotransmitter secretionGO:004692830.017
neurological system processGO:00508771630.017
cellular protein catabolic processGO:00442572610.016
cation transmembrane transportGO:00986552380.016
regulation of locomotionGO:00400123290.016
vesicle mediated transportGO:00161923710.016
interspecies interaction between organismsGO:00444191560.016
positive regulation of synaptic transmissionGO:005080640.016
regulation of viral processGO:00507921030.016
ubiquitin dependent protein catabolic processGO:00065112060.016
leukocyte activationGO:00453211640.016
mononuclear cell proliferationGO:0032943710.016
positive regulation of cellular component organizationGO:00511303760.016
negative regulation of endopeptidase activityGO:0010951840.016
glycerolipid metabolic processGO:00464861070.016
gtp catabolic processGO:00061842370.016
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.016
growthGO:00400072020.016
glutathione metabolic processGO:0006749200.016
cardiovascular system developmentGO:00723582620.016
regulation of cell migrationGO:00303342890.016
intracellular protein transportGO:00068862700.015
response to lipidGO:00339932060.015
segmentationGO:003528240.015
circulatory system developmentGO:00723592620.015
female gamete generationGO:000729220.015
photoreceptor cell differentiationGO:004653020.015
maintenance of locationGO:00512351120.015
regulation of leukocyte activationGO:00026941150.015
negative regulation of protein maturationGO:19033181420.015
positive regulation of phosphorylationGO:00423273940.015
positive regulation of protein complex assemblyGO:0031334860.015
neuron developmentGO:00486661130.015
regulation of membrane potentialGO:0042391950.015
neuron deathGO:0070997650.015
glycoprotein metabolic processGO:00091001100.015
negative regulation of developmental processGO:00510932470.015
transition metal ion homeostasisGO:0055076310.015
regulation of intracellular transportGO:00323861950.015
response to increased oxygen levelsGO:003629640.015
regulation of cell cycle processGO:00105642660.014
positive regulation of innate immune responseGO:0045089790.014
response to hyperoxiaGO:005509340.014
regulation of cell morphogenesisGO:00226041530.014
biological adhesionGO:00226103310.014
cellular amide metabolic processGO:0043603690.014
cellular lipid metabolic processGO:00442553030.014
regulation of cysteine type endopeptidase activityGO:20001161270.014
nitrogen compound transportGO:00717051910.014
agingGO:0007568660.014
regulation of response to biotic stimulusGO:0002831550.014
metal ion homeostasisGO:00550651690.014
t cell activationGO:0042110990.014
regulation of protein complex assemblyGO:00432541470.014
regulation of response to oxidative stressGO:1902882260.014
positive regulation of apoptotic processGO:00430652460.014
spermatid differentiationGO:004851540.014
negative regulation of cell differentiationGO:00455961710.014
neuron apoptotic processGO:0051402390.014
hemostasisGO:0007599760.014
cell projection morphogenesisGO:00488581290.014
guanosine containing compound catabolic processGO:19010692390.014
regulation of mitochondrial membrane potentialGO:0051881230.013
vascular process in circulatory systemGO:0003018290.013
regulation of neurogenesisGO:0050767820.013
rna interferenceGO:001624640.013
regulation of defense response to virus by hostGO:0050691220.013
positive regulation of secretion by cellGO:19035321080.013
transmembrane transportGO:00550853990.013
circulatory system processGO:00030131130.013
negative regulation of catabolic processGO:00098951040.013
response to uvGO:0009411730.013
negative regulation of cellular amino acid metabolic processGO:004576320.013
i kappab kinase nf kappab signalingGO:00072491660.013
response to transition metal nanoparticleGO:1990267290.013
sequestering of calcium ionGO:0051208170.013
blood vessel morphogenesisGO:00485141620.013
spermatid developmentGO:000728640.013
release of cytochrome c from mitochondriaGO:0001836350.013
mitotic cell cycle phase transitionGO:00447721620.013
ras protein signal transductionGO:0007265730.013
immune response activating signal transductionGO:0002757900.013
monocarboxylic acid metabolic processGO:00327871850.013
cellular response to molecule of bacterial originGO:0071219620.013
protein autophosphorylationGO:00467771230.013
activation of innate immune responseGO:0002218550.013
deoxyribose phosphate metabolic processGO:001969260.012
inorganic ion transmembrane transportGO:00986602310.012
negative regulation of growthGO:0045926970.012
response to inorganic substanceGO:00100351270.012
regulation of cell projection organizationGO:00313441070.012
positive regulation of cellular component biogenesisGO:00440891580.012
sequestering of metal ionGO:0051238240.012
single organism reproductive processGO:0044702980.012
response to activityGO:001482300.012
regulation of proteolysisGO:00301622930.012
response to woundingGO:00096111680.012
cellular response to organic cyclic compoundGO:00714071270.012
positive regulation of nucleotide catabolic processGO:00308131850.012
cell adhesionGO:00071553250.012
regulation of peptidyl tyrosine phosphorylationGO:00507301080.012
positive regulation of purine nucleotide catabolic processGO:00331231850.012
lipid localizationGO:00108761060.012
negative regulation of transportGO:00510511760.012
regulation of wnt signaling pathwayGO:00301111230.012
neurotransmitter secretionGO:000726940.012
stress activated protein kinase signaling cascadeGO:0031098940.012
lymphocyte proliferationGO:0046651700.012
protein dna complex subunit organizationGO:0071824800.012
cellular response to external stimulusGO:00714961110.012
proteasomal protein catabolic processGO:00104981760.012
small gtpase mediated signal transductionGO:0007264780.012
regulation of stress activated protein kinase signaling cascadeGO:0070302850.012
inorganic cation transmembrane transportGO:00986621940.012
protein importGO:00170381300.012
chromatin modificationGO:00165682980.012
intracellular receptor signaling pathwayGO:00305221040.012
embryo developmentGO:00097901230.012
system processGO:00030083490.012
regulation of meiotic cell cycleGO:005144540.011
small molecule biosynthetic processGO:00442831570.011
dendrite developmentGO:0016358240.011
regulation of ion transmembrane transportGO:00347651320.011
translationGO:00064121320.011
regulation of chromosome organizationGO:00330441030.011
cellular response to cytokine stimulusGO:00713451810.011
regulation of cytoskeleton organizationGO:00514931770.011
cellular response to abiotic stimulusGO:00712141170.011
regulation of innate immune responseGO:0045088970.011
actin cytoskeleton organizationGO:00300362070.011
metal ion transportGO:00300012720.011
response to purine containing compoundGO:0014074400.011
behaviorGO:00076101120.011
g protein coupled receptor signaling pathwayGO:00071862070.011
regulation of peptidase activityGO:00525471800.011
neuron projection morphogenesisGO:0048812500.011
cell growthGO:00160491600.011
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.011
cellular homeostasisGO:00197251960.011
negative regulation of oxidative stress induced cell deathGO:1903202170.011
regulation of antimicrobial humoral responseGO:000275910.011
negative regulation of mapk cascadeGO:0043409560.011
pyridine nucleotide metabolic processGO:0019362140.011
positive regulation of cellular amino acid metabolic processGO:004576430.011
regulation of neuron deathGO:1901214560.011
response to oxygen levelsGO:00704821000.011
fat cell differentiationGO:0045444320.011
cation homeostasisGO:00550801890.011
oxidoreduction coenzyme metabolic processGO:0006733190.011
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.011
primary neural tube formationGO:001402030.011
myeloid leukocyte differentiationGO:0002573600.011
cation transportGO:00068123310.011
syncytium formation by plasma membrane fusionGO:000076820.011
glycosylationGO:0070085710.011
cell cycle phase transitionGO:00447701730.011
cytosolic calcium ion transportGO:0060401480.011
regulation of sequence specific dna binding transcription factor activityGO:00510902110.011
regulation of tube sizeGO:0035150180.011
cellular carbohydrate metabolic processGO:0044262840.011
glycerolipid biosynthetic processGO:0045017510.011
membrane lipid metabolic processGO:0006643530.011
regulation of body fluid levelsGO:0050878990.011
cell cycle arrestGO:0007050710.011
regulation of mitotic cell cycleGO:00073461890.011
anterior posterior axis specificationGO:000994820.011
regulation of metal ion transportGO:00109591200.011
protein ubiquitinationGO:00165673140.011
regulation of cytoplasmic transportGO:19036491490.010
small molecule catabolic processGO:0044282920.010
cellular response to extracellular stimulusGO:0031668720.010
peptide metabolic processGO:0006518510.010
positive regulation of transportGO:00510503360.010
membrane organizationGO:00610242920.010
myosin filament organizationGO:003103320.010
regulation of lymphocyte activationGO:00512491030.010
digestive tract developmentGO:0048565750.010
glycoprotein biosynthetic processGO:0009101910.010
negative regulation of cellular component organizationGO:00511292350.010
positive regulation of cell motilityGO:20001471770.010
modification dependent macromolecule catabolic processGO:00436322120.010
adaptive immune responseGO:0002250490.010
regulation of protein polymerizationGO:0032271630.010
protein homooligomerizationGO:00512601000.010
regulation of protein transportGO:00512232130.010
negative regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043154460.010
endocytosisGO:00068971590.010
regulation of oxidative stress induced intrinsic apoptotic signaling pathwayGO:1902175160.010
regulation of defense response to virusGO:0050688330.010
regulation of bindingGO:00510981110.010

GCH1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:145661740.026
cancerDOID:1621670.023
organ system cancerDOID:00506861640.021
immune system diseaseDOID:29141550.015
musculoskeletal system diseaseDOID:172230.015
nervous system diseaseDOID:8634310.012
sensory system diseaseDOID:00501552030.012
eye and adnexa diseaseDOID:14921500.010