Homo sapiens

63 known processes

AKR1D1

aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)

(Aliases: SRD5B1,3o5bred,CBAS2)

AKR1D1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular amino acid metabolic processGO:00065201160.168
lipid metabolic processGO:00066293810.149
cellular ketone metabolic processGO:0042180800.116
Human
steroid metabolic processGO:0008202940.114
anion transportGO:00068201610.112
chemical homeostasisGO:00488783060.096
organic hydroxy compound metabolic processGO:19016151470.096
monocarboxylic acid metabolic processGO:00327871850.088
cellular amine metabolic processGO:0044106410.088
cellular lipid metabolic processGO:00442553030.086
Human
response to organic cyclic compoundGO:00140702040.082
Human
regulation of cellular amino acid metabolic processGO:000652160.079
small molecule biosynthetic processGO:00442831570.079
regulation of cellular amine metabolic processGO:0033238110.078
negative regulation of multicellular organismal processGO:00512413170.073
system processGO:00030083490.068
g protein coupled receptor signaling pathwayGO:00071862070.068
Human
amine metabolic processGO:0009308440.066
regulation of cellular ketone metabolic processGO:0010565500.065
Human
leukotriene b4 metabolic processGO:003610220.065
regulation of transmission of nerve impulseGO:005196920.063
positive regulation of acrosome reactionGO:200034440.063
defense responseGO:00069523150.061
post embryonic developmentGO:000979120.060
positive regulation of cellular amino acid metabolic processGO:004576430.060
ion transmembrane transportGO:00342203380.059
organic anion transportGO:00157111030.056
oxidation reduction processGO:00551143960.056
positive regulation of cellular amine metabolic processGO:003324070.055
transmembrane transportGO:00550853990.055
negative regulation of protein metabolic processGO:00512483910.053
response to oxygen containing compoundGO:19017003690.053
Human
positive regulation of transportGO:00510503360.052
cellular response to histamineGO:007142030.052
regulation of acrosome reactionGO:006004640.051
regulation of response to external stimulusGO:00321012220.050
organic acid biosynthetic processGO:0016053970.049
regulation of cell migrationGO:00303342890.047
response to nitrogen compoundGO:19016981840.045
nitrogen cycle metabolic processGO:007194130.044
protein maturationGO:00516042330.044
regulation of anatomical structure morphogenesisGO:00226032860.043
regenerationGO:003109940.043
regulation of locomotionGO:00400123290.043
fatty acid derivative catabolic processGO:190156920.042
phenylpropanoid metabolic processGO:000969830.042
vesicle mediated transportGO:00161923710.041
epoxygenase p450 pathwayGO:001937330.041
lipid biosynthetic processGO:00086101770.041
lipid catabolic processGO:0016042840.040
negative regulation of catalytic activityGO:00430863350.040
regulation of cell differentiationGO:00455953930.040
negative regulation of transmission of nerve impulseGO:005197010.039
positive regulation of phosphorylationGO:00423273940.037
ion homeostasisGO:00508012300.036
negative regulation of cellular protein metabolic processGO:00322693530.036
immune responseGO:00069553070.035
fatty acid metabolic processGO:00066311150.034
Human
positive regulation of protein phosphorylationGO:00019343130.034
anatomical structure formation involved in morphogenesisGO:00486462840.034
oogenesisGO:004847720.034
cation homeostasisGO:00550801890.034
protein processingGO:00164852260.033
response to woundingGO:00096111680.033
negative regulation of interleukin 5 secretionGO:200066310.033
cellular response to growth factor stimulusGO:00713631970.033
regulation of body fluid levelsGO:0050878990.033
vitamin e metabolic processGO:004236010.033
negative regulation of programmed cell deathGO:00430693210.032
cellular homeostasisGO:00197251960.032
biological adhesionGO:00226103310.032
secretionGO:00469032540.032
regulation of hormone levelsGO:00108171250.032
negative regulation of cell deathGO:00605483450.032
regulation of secretionGO:00510461940.031
small molecule catabolic processGO:0044282920.031
regulation of cellular component movementGO:00512703340.031
negative regulation of hydrolase activityGO:00513461820.031
alcohol metabolic processGO:00060661140.031
reactive oxygen species metabolic processGO:0072593750.031
Human
cytoplasmic transportGO:00164823790.031
Human
multicellular organismal agingGO:001025930.031
signal transduction by phosphorylationGO:00230142970.031
innate immune responseGO:00450871780.030
coagulationGO:0050817780.030
inorganic anion transmembrane transportGO:0098661470.030
negative regulation of icosanoid secretionGO:003230420.030
cell adhesionGO:00071553250.030
carbohydrate metabolic processGO:00059752070.030
carboxylic acid biosynthetic processGO:0046394970.030
response to hormoneGO:00097251750.030
Human
negative regulation of developmental processGO:00510932470.030
urea metabolic processGO:001962730.030
cation transportGO:00068123310.030
positive regulation of immune system processGO:00026842830.029
cellular response to endogenous stimulusGO:00714953360.029
Human
apoptotic signaling pathwayGO:00971902680.029
organophosphate catabolic processGO:00464344300.029
regulation of cytokine productionGO:00018172320.029
female gamete generationGO:000729220.029
regulation of response to woundingGO:19030341010.029
cofactor metabolic processGO:0051186870.029
Human
vitamin k catabolic processGO:004237720.029
response to lipidGO:00339932060.028
Human
enzyme linked receptor protein signaling pathwayGO:00071673030.028
fatty acid omega oxidationGO:001043020.028
determination of adult lifespanGO:000834020.028
cellular chemical homeostasisGO:00550821800.028
organonitrogen compound biosynthetic processGO:19015662000.028
cytokine productionGO:00018162470.028
carboxylic acid catabolic processGO:0046395710.028
sulfur compound metabolic processGO:00067901010.027
response to inorganic substanceGO:00100351270.027
Human
purine ribonucleoside metabolic processGO:00461284370.027
negative regulation of apoptotic processGO:00430663160.027
cellular cation homeostasisGO:00300031630.027
cellular response to oxygen containing compoundGO:19017012760.027
Human
cellular lipid catabolic processGO:0044242650.027
Human
positive regulation of cell proliferationGO:00082843010.027
Human
response to abiotic stimulusGO:00096283360.027
positive regulation of cellular component organizationGO:00511303760.027
gamma aminobutyric acid signaling pathwayGO:000721430.026
regulation of secretion by cellGO:19035301770.026
mapk cascadeGO:00001652880.026
maintenance of locationGO:00512351120.026
inorganic ion transmembrane transportGO:00986602310.026
positive regulation of developmental processGO:00510943140.026
locomotory behaviorGO:000762610.026
metal ion transportGO:00300012720.026
secretion by cellGO:00329402260.026
response to growth factorGO:00708482050.026
positive regulation of cell migrationGO:00303351720.026
nervous system developmentGO:00073992930.025
carboxylic acid transportGO:0046942630.025
vasculature developmentGO:00019441810.025
response to steroid hormoneGO:0048545800.025
Human
chemotaxisGO:00069351570.025
cardiovascular system developmentGO:00723582620.025
response to other organismGO:00517072610.025
icosanoid metabolic processGO:0006690350.024
Human
response to organonitrogen compoundGO:00102431560.024
organic acid transportGO:0015849650.024
regulation of endopeptidase activityGO:00525481700.024
single organism carbohydrate metabolic processGO:00447231930.024
phylloquinone metabolic processGO:004237420.024
blood vessel morphogenesisGO:00485141620.024
negative regulation of protein maturationGO:19033181420.024
hemostasisGO:0007599760.024
response to external biotic stimulusGO:00432072610.024
lipid transportGO:0006869900.024
purine nucleoside triphosphate metabolic processGO:00091444120.023
cellular response to organic cyclic compoundGO:00714071270.023
Human
positive regulation of cellular component movementGO:00512721810.023
regulation of cell cycleGO:00517263930.023
regulation of transferase activityGO:00513383550.023
regulation of ion transportGO:00432691890.023
leukotriene catabolic processGO:003610020.023
regulation of proteolysisGO:00301622930.023
lipid localizationGO:00108761060.023
single organism membrane organizationGO:00448022680.023
membrane organizationGO:00610242920.023
alkaloid metabolic processGO:000982040.022
cellular macromolecule catabolic processGO:00442653800.022
cellular response to nitrogen compoundGO:19016991440.022
negative regulation of phosphate metabolic processGO:00459362670.022
regulation of vesicle mediated transportGO:00606271300.022
regulation of protein maturationGO:19033171500.022
regulation of cell motilityGO:20001452990.022
anion transmembrane transportGO:0098656760.022
regulation of immune responseGO:00507762010.022
cation transmembrane transportGO:00986552380.022
divalent metal ion transportGO:00708381520.021
regulation of protein processingGO:00706131500.021
ras protein signal transductionGO:0007265730.021
response to cytokineGO:00340972320.021
negative regulation of transportGO:00510511760.021
blood coagulationGO:0007596760.021
regulation of protein localizationGO:00328802960.021
negative regulation of cellular component organizationGO:00511292350.021
response to biotic stimulusGO:00096072760.021
estrogen catabolic processGO:000671110.021
regulation of cell adhesionGO:00301551660.021
regulation of kinase activityGO:00435493140.021
carbohydrate derivative biosynthetic processGO:19011372070.021
circulatory system developmentGO:00723592620.021
positive regulation of secretion by cellGO:19035321080.021
positive regulation of mapk cascadeGO:00434101900.021
coenzyme metabolic processGO:0006732650.021
purine ribonucleoside triphosphate metabolic processGO:00092054110.020
actin filament based processGO:00300292240.020
regulation of vasculature developmentGO:1901342970.020
organic acid catabolic processGO:0016054710.020
negative regulation of protein processingGO:00109551420.020
metal ion homeostasisGO:00550651690.020
regulation of reactive oxygen species metabolic processGO:2000377410.020
Human
negative regulation of proteolysisGO:00458611320.020
purine ribonucleoside triphosphate catabolic processGO:00092073910.020
positive regulation of transferase activityGO:00513472270.020
single organism cellular localizationGO:19025803320.020
Human
positive regulation of locomotionGO:00400171860.020
long chain fatty acid metabolic processGO:0001676300.020
cellular modified amino acid metabolic processGO:0006575640.020
positive regulation of programmed cell deathGO:00430682490.020
Human
regulation of wound healingGO:0061041560.020
memoryGO:000761330.020
regulation of defense responseGO:00313471540.020
regulation of peptidase activityGO:00525471800.020
quinone catabolic processGO:190166220.020
regulation of blood coagulationGO:0030193420.020
positive regulation of cell motilityGO:20001471770.019
sensory perception of smellGO:000760820.019
ribonucleoside catabolic processGO:00424544060.019
wound healingGO:00420601150.019
positive regulation of hydrolase activityGO:00513453310.019
regulation of mapk cascadeGO:00434082620.019
response to drugGO:0042493810.019
blood circulationGO:00080151130.019
sialic acid transportGO:001573910.019
taxisGO:00423301570.019
peptidyl tyrosine modificationGO:00182121700.019
angiogenesisGO:00015251470.019
cell cell signalingGO:00072671550.019
regulation of system processGO:00440571010.019
menaquinone metabolic processGO:000923330.019
regulation of apoptotic signaling pathwayGO:20012331750.019
cellular divalent inorganic cation homeostasisGO:00725031280.019
cellular ion homeostasisGO:00068731680.019
segmentationGO:003528240.019
negative regulation of phosphorus metabolic processGO:00105632670.019
regulation of phospholipase c activating g protein coupled receptor signaling pathwayGO:190073610.019
regulation of protein kinase activityGO:00458592890.018
mitotic cell cycleGO:00002783260.018
regulation of protein transportGO:00512232130.018
glycosyl compound catabolic processGO:19016584130.018
negative regulation of cellular organohalogen metabolic processGO:009034910.018
positive regulation of catabolic processGO:00098963100.018
regulation of angiogenesisGO:0045765920.018
cell activationGO:00017752130.018
single organism cell adhesionGO:00986021790.018
negative regulation of cell differentiationGO:00455961710.018
ribonucleoside triphosphate metabolic processGO:00091994120.018
cellular macromolecular complex assemblyGO:00346223240.018
positive regulation of secretionGO:00510471160.018
regulation of establishment of protein localizationGO:00702012420.018
regulation of multi organism processGO:00439001570.018
icosanoid catabolic processGO:190152320.018
purine nucleotide catabolic processGO:00061954050.018
tissue regenerationGO:004224630.018
purine containing compound catabolic processGO:00725234110.018
response to metal ionGO:0010038840.018
Human
positive regulation of cell deathGO:00109422630.018
Human
regulation of coagulationGO:0050818440.017
divalent inorganic cation transportGO:00725111580.017
hindbrain developmentGO:003090230.017
negative regulation of neurological system processGO:003164520.017
nucleoside triphosphate catabolic processGO:00091433940.017
small gtpase mediated signal transductionGO:0007264780.017
nucleoside phosphate catabolic processGO:19012924120.017
cell developmentGO:00484683280.017
organic hydroxy compound biosynthetic processGO:1901617710.017
sequestering of metal ionGO:0051238240.017
cellular organohalogen metabolic processGO:009034520.017
positive regulation of cellular catabolic processGO:00313312840.017
cellular response to genisteinGO:007141210.017
cellular metal ion homeostasisGO:00068751460.017
neurological system processGO:00508771630.017
protein catabolic processGO:00301633250.017
protein oligomerizationGO:00512591730.017
Human
negative regulation of locomotionGO:00400131180.017
regulation of intracellular transportGO:00323861950.017
nucleotide catabolic processGO:00091664080.017
regulation of cellular response to stressGO:00801352440.017
cell projection organizationGO:00300302520.017
neuromuscular junction developmentGO:000752830.017
ribonucleoside triphosphate catabolic processGO:00092033910.017
nucleoside triphosphate metabolic processGO:00091414220.017
cellular protein catabolic processGO:00442572610.017
reactive oxygen species biosynthetic processGO:190340940.017
cellular response to ammonium ionGO:007124240.017
naphthalene metabolic processGO:001893110.017
positive regulation of synaptic transmissionGO:005080640.017
regulation of lipid metabolic processGO:0019216960.017
Human
response to bacteriumGO:00096171440.016
cell morphogenesisGO:00009022960.016
ribonucleotide catabolic processGO:00092614050.016
purine nucleoside triphosphate catabolic processGO:00091463920.016
exocytosisGO:0006887710.016
spermatid differentiationGO:004851540.016
dephosphorylationGO:00163112090.016
regulation of cell cycle processGO:00105642660.016
alpha amino acid metabolic processGO:1901605720.016
positive regulation of apoptotic processGO:00430652460.016
Human
mitotic cell cycle processGO:19030472860.016
peptidyl tyrosine phosphorylationGO:00181081700.016
nitrogen compound transportGO:00717051910.016
negative regulation of peptidase activityGO:0010466910.016
negative regulation of protein modification processGO:00314002000.016
blood vessel developmentGO:00015681720.016
positive regulation of peptidyl serine phosphorylation of stat proteinGO:003314130.016
divalent inorganic cation homeostasisGO:00725071360.016
protein localization to organelleGO:00333652800.016
Human
chloride transportGO:0006821410.016
cell chemotaxisGO:00603261120.016
endocytosisGO:00068971590.016
inorganic anion transportGO:0015698600.016
isoquinoline alkaloid metabolic processGO:003307610.016
negative regulation of blood coagulationGO:0030195220.016
regulation of hemostasisGO:1900046420.016
negative regulation of cellular amino acid metabolic processGO:004576320.015
oxidative demethylationGO:0070989110.015
muscle contractionGO:0006936730.015
regulation of erk1 and erk2 cascadeGO:0070372990.015
response to fungusGO:000962040.015
monocarboxylic acid biosynthetic processGO:0072330670.015
negative regulation of cellular amine metabolic processGO:003323930.015
cellular response to hydroxyisoflavoneGO:007141310.015
negative regulation of response to external stimulusGO:0032102830.015
regulation of cell morphogenesisGO:00226041530.015
circulatory system processGO:00030131130.015
urate transportGO:001574730.015
protein modification by small protein conjugationGO:00324463420.015
purine ribonucleotide catabolic processGO:00091544040.015
organophosphate biosynthetic processGO:00904071630.015
regulation of nucleotide metabolic processGO:00061402690.015
positive regulation of kinase activityGO:00336742040.015
negative regulation of cellular organofluorine metabolic processGO:009035010.015
response to nutrient levelsGO:0031667810.015
Human
purine ribonucleoside monophosphate metabolic processGO:00091671860.015
regulation of cellular organohalogen metabolic processGO:009034710.015
regulation of meiotic cell cycleGO:005144540.015
cellular response to cytokine stimulusGO:00713451810.015
chloride transmembrane transportGO:1902476380.015
intracellular protein transportGO:00068862700.015
Human
regulation of reactive oxygen species biosynthetic processGO:190342630.015
lipid modificationGO:0030258840.015
positive regulation of peptidyl tyrosine phosphorylationGO:0050731850.015
positive regulation of immune responseGO:00507781590.015
regulation of growthGO:00400081650.015
reactive nitrogen species metabolic processGO:200105730.015
cellular response to dna damage stimulusGO:00069743790.015
rho protein signal transductionGO:0007266260.015
limbic system developmentGO:002176130.015
interspecies interaction between organismsGO:00444191560.015
organic hydroxy compound transportGO:0015850630.015
cellular amide metabolic processGO:0043603690.014
regulation of cell growthGO:00015581350.014
regulation of synaptic plasticityGO:004816730.014
purine ribonucleoside catabolic processGO:00461303980.014
sequestering of calcium ionGO:0051208170.014
behaviorGO:00076101120.014
protein targetingGO:00066051870.014
Human
cellular response to external stimulusGO:00714961110.014
Human
defense response to other organismGO:00985421290.014
cholesterol homeostasisGO:0042632280.014
negative regulation of endopeptidase activityGO:0010951840.014
protein ubiquitinationGO:00165673140.014
purine nucleoside catabolic processGO:00061523980.014
cell growthGO:00160491600.014
cellular response to organonitrogen compoundGO:00714171240.014
associative learningGO:000830610.014
positive regulation of protein kinase activityGO:00458601900.014
proteolysis involved in cellular protein catabolic processGO:00516032440.014
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.014
astrocyte differentiationGO:004870840.014
fatty acid derivative metabolic processGO:1901568350.014
Human
isoprenoid metabolic processGO:0006720390.014
Human
oocyte developmentGO:004859910.014
cell fate determinationGO:000170930.014
arachidonic acid metabolic processGO:0019369140.014
positive regulation of cytokine productionGO:00018191670.014
salivary gland morphogenesisGO:000743540.014
atp metabolic processGO:00460341760.014
regulation of sequence specific dna binding transcription factor activityGO:00510902110.014
negative regulation of intracellular signal transductionGO:19025321830.014
hormone metabolic processGO:0042445610.014
response to extracellular stimulusGO:0009991850.014
Human
morphogenesis of embryonic epitheliumGO:001633140.014
positive regulation of purine nucleotide metabolic processGO:19005442270.014
cellular protein complex assemblyGO:00436231880.014
regulation of membrane potentialGO:0042391950.014
leukotriene b4 catabolic processGO:003610120.014
protein homooligomerizationGO:00512601000.014
Human
response to axon injuryGO:004867810.014
nucleoside monophosphate metabolic processGO:00091231910.014
spermatid developmentGO:000728640.014
regulation of cell developmentGO:00602841610.014
unsaturated fatty acid metabolic processGO:0033559370.014
Human
cellular component morphogenesisGO:00329893140.014
hematopoietic or lymphoid organ developmentGO:00485341860.014
adult locomotory behaviorGO:000834410.014
immune system developmentGO:00025201950.013
oocyte differentiationGO:000999420.013
tissue migrationGO:00901301190.013
motor neuron axon guidanceGO:000804520.013
positive regulation of protein transportGO:00512221350.013
purine nucleoside monophosphate metabolic processGO:00091261860.013
cellular response to hormone stimulusGO:00328701250.013
Human
negative regulation of cell cycleGO:00457861930.013
positive regulation of cell differentiationGO:00455972110.013
positive regulation of vasoconstrictionGO:004590730.013
blastoderm segmentationGO:000735020.013
regulation of epithelial cell migrationGO:0010632930.013
regulation of cysteine type endopeptidase activityGO:20001161270.013
zymogen activationGO:0031638700.013
ribonucleoside monophosphate metabolic processGO:00091611870.013
cellular calcium ion homeostasisGO:00068741170.013
sensory perceptionGO:00076001030.013
regulation of homeostatic processGO:00328441210.013
immune effector processGO:00022521590.013
androgen biosynthetic processGO:000670230.013
Human
nucleoside catabolic processGO:00091644080.013
regulation of cytoplasmic transportGO:19036491490.013
phylloquinone catabolic processGO:004237620.013
calcium ion homeostasisGO:00550741220.013
rhythmic behaviorGO:000762220.013
cellular response to lipidGO:00713961270.013
Human
regulation of peptidyl tyrosine phosphorylationGO:00507301080.013
negative regulation of organelle organizationGO:00106391260.013
cd4 positive alpha beta t cell cytokine productionGO:003574340.013
erk1 and erk2 cascadeGO:00703711040.013
hemopoiesisGO:00300971800.013
growthGO:00400072020.013
peripheral nervous system developmentGO:000742220.013
epithelium migrationGO:00901321190.013
positive regulation of organic acid transportGO:003289230.013
av node cell to bundle of his cell communicationGO:008606740.013
activation of immune responseGO:00022531140.013
calcium ion transportGO:00068161470.013
vitamin k biosynthetic processGO:004237120.013
striated muscle contractionGO:0006941520.013
muscle system processGO:0003012810.013
regulation of cell activationGO:00508651250.012
posttranscriptional regulation of gene expressionGO:00106082130.012
positive regulation of response to external stimulusGO:0032103880.012
symbiosis encompassing mutualism through parasitismGO:00444031560.012
positive regulation of cell adhesionGO:0045785840.012
syncytium formation by plasma membrane fusionGO:000076820.012
naphthalene containing compound metabolic processGO:009042010.012
protein secretionGO:0009306980.012
phospholipid metabolic processGO:0006644990.012
negative regulation of apoptotic signaling pathwayGO:2001234970.012
regulation of innate immune responseGO:0045088970.012
regulation of high density lipoprotein particle clearanceGO:001098220.012
defense response to fungusGO:005083240.012
matingGO:000761810.012
negative regulation of phosphorylationGO:00423261740.012
negative regulation of response to woundingGO:1903035470.012
linoleic acid metabolic processGO:004365140.012
regulation of dna metabolic processGO:00510521530.012
rna processingGO:00063962550.012
positive regulation of defense responseGO:0031349870.012
chromatin modificationGO:00165682980.012
cell substrate adhesionGO:00315891320.012
intracellular receptor signaling pathwayGO:00305221040.012
Human
positive regulation of nucleotide metabolic processGO:00459812300.012
sterol homeostasisGO:0055092280.012
microtubule based processGO:00070172100.012
compound eye developmentGO:004874910.012
positive regulation of intracellular transportGO:00323881040.012
release of cytoplasmic sequestered nf kappabGO:000858840.012
protein localization to membraneGO:00726571600.012
renal system process involved in regulation of blood volumeGO:000197740.012
startle responseGO:000196430.012
positive regulation of angiogenesisGO:0045766510.012
regulation of glial cell differentiationGO:004568530.012
chromatin organizationGO:00063253510.012
cell cycle phase transitionGO:00447701730.012
viral processGO:00160321460.011
response to oxidative stressGO:00069791210.011
Human
regulation of protein secretionGO:0050708860.011
mitochondrion organizationGO:00070051560.011
regulation of bindingGO:00510981110.011
regulation of cellular component biogenesisGO:00440872810.011
response to hypoxiaGO:0001666960.011
single organismal cell cell adhesionGO:00163371480.011

AKR1D1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.066
inherited metabolic disorderDOID:6552420.050
sensory system diseaseDOID:00501552030.028
nervous system diseaseDOID:8634310.028
immune system diseaseDOID:29141550.025
eye diseaseDOID:56141490.024
eye and adnexa diseaseDOID:14921500.024
cancerDOID:1621670.023
disease of cellular proliferationDOID:145661740.023
amino acid metabolic disorderDOID:9252500.019
hematopoietic system diseaseDOID:741000.019
central nervous system diseaseDOID:3311860.019
organ system cancerDOID:00506861640.019
musculoskeletal system diseaseDOID:172230.018
retinal diseaseDOID:56791180.017
connective tissue diseaseDOID:651090.014
cardiovascular system diseaseDOID:12871060.014
bone diseaseDOID:0080001880.012